4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine has been researched along with web 2086 in 12 studies
| Studies (4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine) | Trials (4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine) | Recent Studies (post-2010) (4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine) | Studies (web 2086) | Trials (web 2086) | Recent Studies (post-2010) (web 2086) |
|---|---|---|---|---|---|
| 51 | 1 | 8 | 600 | 8 | 31 |
| Protein | Taxonomy | 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine (IC50) | web 2086 (IC50) |
|---|---|---|---|
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | 0.1093 | |
| Platelet-activating factor receptor | Homo sapiens (human) | 0.1735 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (91.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bito, H; Honda, Z; Izumi, T; Matsumoto, T; Minami, M; Mutoh, H; Nakamura, M; Noma, M; Sakanaka, C; Seyama, Y | 1 |
| Mikashima, H; Muramoto, Y; Setoguchi, M; Tahara, T; Takehara, S; Terasawa, M | 1 |
| Komatsu, H; Nagasawa, M; Okumoto, T | 1 |
| Fukuda, T; Makino, S; Sagara, H | 1 |
| Iwahisa, Y; Kagoshima, M; Terasawa, M; Yamaguchi, S | 1 |
| Iwahisa, Y; Kagoshima, M; Kawakami, Y; Terasawa, M; Tomomatsu, N; Yamaguchi, S | 2 |
| Kagoshima, M; Kohge, S; Terasawa, M; Yamaguchi, S | 1 |
| Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R | 1 |
| Kagoshima, M; Komatsu, H; Okumoto, T; Tomomatsu, N; Yamaguchi, S | 1 |
| Amano, M; Komatsu, H; Sugahara, K; Yamaguchi, S | 1 |
| Komatsu, H; Kusuhara, H; Matsuyuki, H; Sugahara, K; Terasawa, M; Yamaguchi, S | 1 |
1 review(s) available for 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine and web 2086
| Article | Year |
|---|---|
[PAF receptor antagonist in asthma therapy].
Topics: Animals; Asthma; Azepines; Humans; Platelet Activating Factor; Triazoles | 1996 |
11 other study(ies) available for 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine and web 2086
| Article | Year |
|---|---|
Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.
Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Blotting, Northern; Cell Line; Cloning, Molecular; DNA; Guinea Pigs; Humans; Leukocytes; Membrane Potentials; Molecular Sequence Data; Ovum; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Xenopus laevis | 1991 |
Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors.
Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Brain; Diazepam; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazoles | 1990 |
Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet-activating factor.
Topics: Animals; Antigens, CD; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Edema; Endothelium, Vascular; Guinea Pigs; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Triazoles; Umbilical Veins | 1993 |
Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs.
Topics: Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Linear Models; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles | 1996 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles | 1997 |
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action.
Topics: Acetylcholine; Administration, Oral; Animals; Azepines; Binding Sites; Blood Platelets; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Injections, Intravenous; Leukotriene D4; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Structure-Activity Relationship; Triazoles | 1997 |
Suppressive effects of Y-24180, a long-acting antagonist for platelet-activating factor, on allergic pulmonary eosinophilia in mice.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Azepines; Bronchoalveolar Lavage Fluid; Eosinophils; Interleukin-5; Lung; Male; Mice; Mice, Inbred BALB C; Platelet Aggregation Inhibitors; Prednisolone; Pulmonary Eosinophilia; Triazoles | 1997 |
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles | 1998 |
Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice.
Topics: Animals; Azepines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Ear; Eosinophils; Female; Immunoglobulin E; Kinetics; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1998 |
Inhibition of activation of human peripheral blood eosinophils by Y-24180, an antagonist to platelet-activating factor receptor.
Topics: Azepines; Eosinophils; Humans; Intercellular Adhesion Molecule-1; Leukotriene B4; Macrophage-1 Antigen; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles | 1999 |
Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.
Topics: Animals; Azepines; Cells, Cultured; Gene Expression; Humans; Interleukin-5; Leukocytes, Mononuclear; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Th2 Cells; Triazoles | 2000 |