Page last updated: 2024-09-03

4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine and web 2086

4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine has been researched along with web 2086 in 12 studies

Compound Research Comparison

Studies
(4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine)
Trials
(4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine)
Recent Studies (post-2010)
(4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine)
Studies
(web 2086)
Trials
(web 2086)
Recent Studies (post-2010) (web 2086)
5118600831

Protein Interaction Comparison

ProteinTaxonomy4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine (IC50)web 2086 (IC50)
Platelet-activating factor receptorCavia porcellus (domestic guinea pig)0.1093
Platelet-activating factor receptorHomo sapiens (human)0.1735

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (91.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bito, H; Honda, Z; Izumi, T; Matsumoto, T; Minami, M; Mutoh, H; Nakamura, M; Noma, M; Sakanaka, C; Seyama, Y1
Mikashima, H; Muramoto, Y; Setoguchi, M; Tahara, T; Takehara, S; Terasawa, M1
Komatsu, H; Nagasawa, M; Okumoto, T1
Fukuda, T; Makino, S; Sagara, H1
Iwahisa, Y; Kagoshima, M; Terasawa, M; Yamaguchi, S1
Iwahisa, Y; Kagoshima, M; Kawakami, Y; Terasawa, M; Tomomatsu, N; Yamaguchi, S2
Kagoshima, M; Kohge, S; Terasawa, M; Yamaguchi, S1
Akiyama, M; Ino, M; Miwa, M; Shimura, M; Sugatani, J; Suzuki, M; Suzuki, Y; Yamazaki, R1
Kagoshima, M; Komatsu, H; Okumoto, T; Tomomatsu, N; Yamaguchi, S1
Amano, M; Komatsu, H; Sugahara, K; Yamaguchi, S1
Komatsu, H; Kusuhara, H; Matsuyuki, H; Sugahara, K; Terasawa, M; Yamaguchi, S1

Reviews

1 review(s) available for 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine and web 2086

ArticleYear
[PAF receptor antagonist in asthma therapy].
    Nihon rinsho. Japanese journal of clinical medicine, 1996, Volume: 54, Issue:11

    Topics: Animals; Asthma; Azepines; Humans; Platelet Activating Factor; Triazoles

1996

Other Studies

11 other study(ies) available for 4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6h-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine and web 2086

ArticleYear
Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.
    The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30

    Topics: Amino Acid Sequence; Animals; Azepines; Base Sequence; Blotting, Northern; Cell Line; Cloning, Molecular; DNA; Guinea Pigs; Humans; Leukocytes; Membrane Potentials; Molecular Sequence Data; Ovum; Phosphatidylinositols; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Conformation; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Triazoles; Xenopus laevis

1991
Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors.
    Prostaglandins, 1990, Volume: 40, Issue:6

    Topics: Animals; Azepines; Binding, Competitive; Blood Platelets; Brain; Diazepam; Humans; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, GABA-A; Triazoles

1990
Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet-activating factor.
    International journal of immunopharmacology, 1993, Volume: 15, Issue:6

    Topics: Animals; Antigens, CD; Azepines; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Edema; Endothelium, Vascular; Guinea Pigs; Humans; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred BALB C; Platelet Activating Factor; Triazoles; Umbilical Veins

1993
Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs.
    Japanese journal of pharmacology, 1996, Volume: 72, Issue:3

    Topics: Animals; Antigens; Azepines; Bronchi; Capillary Permeability; Dose-Response Relationship, Drug; Guinea Pigs; Linear Models; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Trachea; Triazoles

1996
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
    Pharmacology, 1997, Volume: 54, Issue:1

    Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; Drug Interactions; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Male; Methacrylates; Platelet Activating Factor; Theophylline; Triazoles

1997
Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action.
    Pharmacology, 1997, Volume: 54, Issue:5

    Topics: Acetylcholine; Administration, Oral; Animals; Azepines; Binding Sites; Blood Platelets; Bradykinin; Bronchial Hyperreactivity; Bronchoconstriction; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Injections, Intravenous; Leukotriene D4; Male; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serotonin; Structure-Activity Relationship; Triazoles

1997
Suppressive effects of Y-24180, a long-acting antagonist for platelet-activating factor, on allergic pulmonary eosinophilia in mice.
    Japanese journal of pharmacology, 1997, Volume: 75, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Asthma; Azepines; Bronchoalveolar Lavage Fluid; Eosinophils; Interleukin-5; Lung; Male; Mice; Mice, Inbred BALB C; Platelet Aggregation Inhibitors; Prednisolone; Pulmonary Eosinophilia; Triazoles

1997
Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Animals; Azepines; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Neutrophils; P-Selectin; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Rabbits; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Thiazoles; Thiazolidines; Triazoles

1998
Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:12

    Topics: Animals; Azepines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Ear; Eosinophils; Female; Immunoglobulin E; Kinetics; Macrophages; Mice; Mice, Inbred BALB C; Monocytes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prednisolone; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1998
Inhibition of activation of human peripheral blood eosinophils by Y-24180, an antagonist to platelet-activating factor receptor.
    Life sciences, 1999, Volume: 65, Issue:13

    Topics: Azepines; Eosinophils; Humans; Intercellular Adhesion Molecule-1; Leukotriene B4; Macrophage-1 Antigen; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Triazoles

1999
Y-24180, an antagonist of platelet-activating factor, suppresses interleukin 5 production in cultured murine th(2)cells and human peripheral blood mononuclear cells.
    Cytokine, 2000, Volume: 12, Issue:7

    Topics: Animals; Azepines; Cells, Cultured; Gene Expression; Humans; Interleukin-5; Leukocytes, Mononuclear; Mice; Platelet Activating Factor; Platelet Aggregation Inhibitors; Th2 Cells; Triazoles

2000