4-(2-(indol-3-yl)vinyl)-1-methylpyridinium and 4-4-difluoro-4-bora-3a-4a-diaza-s-indacene

4-(2-(indol-3-yl)vinyl)-1-methylpyridinium has been researched along with 4-4-difluoro-4-bora-3a-4a-diaza-s-indacene* in 1 studies

Other Studies

1 other study(ies) available for 4-(2-(indol-3-yl)vinyl)-1-methylpyridinium and 4-4-difluoro-4-bora-3a-4a-diaza-s-indacene

ArticleYear
A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells.
    Scientific reports, 2015, Sep-04, Volume: 5

    Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

    Topics: Animals; Antineoplastic Agents; Apoptosis; Boron Compounds; Cell Line, Tumor; Cell Survival; Contrast Media; Fluorescent Dyes; Humans; Indoles; Mice; Microscopy, Fluorescence; Mitochondria; Neoplasms, Experimental; Pyridinium Compounds; Reproducibility of Results; Sensitivity and Specificity

2015