3-phosphonopyruvate and phosphonoacetaldehyde

3-phosphonopyruvate has been researched along with phosphonoacetaldehyde* in 2 studies

Other Studies

2 other study(ies) available for 3-phosphonopyruvate and phosphonoacetaldehyde

ArticleYear
Elucidation of the 2-aminoethylphosphonate biosynthetic pathway in Tetrahymena pyriformis.
    Biochemical and biophysical research communications, 1988, May-31, Volume: 153, Issue:1

    The biosynthetic reaction pathway leading to the natural product, 2-aminoethylphosphonate in Tetrahymena pyriformis has been elucidated. Incubation of [32P]PEP and [14C]PEP with T.pyriformis cellular homogenate fortified with Mg2+ and alanine/pyridoxal phosphate, yielded 2-aminoethylphosphonate as the minor reaction product (2-5% yield) and phosphoglycerate and pyruvate plus orthophosphate as the major products. Inclusion of thiamine pyrophosphate in the reaction mixture increased the yield of 2-aminoethylphosphonate by a factor of 10. Incubation of phosphonoacetaldehyde or phosphonopyruvate in the cellular homogenate also provided 2-aminoethylphosphonate. The cellular homogenate catalyzed the transformation of phosphonoacetaldehyde to 2-aminoethylphosphonate in an ca. 80% yield. However, the maximum yield of 2-aminoethylphosphonic acid obtained by use of phosphonopyruvate was only 15%. The major reaction pathways induced by treatment of phosphonopyruvate with the cellular extract involved its competitive conversion to PEP and pyruvate plus orthophosphate.

    Topics: Acetaldehyde; Alanine; Aminoethylphosphonic Acid; Animals; Magnesium; Magnesium Chloride; Organophosphorus Compounds; Phosphoenolpyruvate; Pyridoxal Phosphate; Pyruvates; Tetrahymena pyriformis; Thiamine Pyrophosphate

1988
Metabolism of 2-amino-3-phosphono[3-14C]propionic acid in cell-free preparations of Tetrahymena.
    Biochimica et biophysica acta, 1980, Jun-23, Volume: 618, Issue:3

    Incubation of 2-amino-3-phosphono[3-14C]propionic acid with cell-free preparations of Tetrahymena pyriformis resulted in incorporation of the radioactivity into phosphoenolpyruvate. No radioactivity was incorporated into phosphoenolpyruvate and 2-phosphonoacetate. Thus, the catabolic pathway of 2-amino-3-phosphonopropionic acid in Tetrahymena appears to be the same route as that found in rats through deamination to produce 3-phosphonopyruvate which is converted to 2-phosphonoacetaldehyde by decarboxylation, followed by both dephosphonylation and amination of the aldehyde to give acetaldehyde and 2-aminoethylphosphonic acid, respectively.

    Topics: Acetaldehyde; Alanine; Aminoethylphosphonic Acid; Animals; Cell-Free System; Organophosphorus Compounds; Pyruvates; Tetrahymena pyriformis

1980
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