3-o-methyl-6-fluoro-dopa has been researched along with dihydroxyphenylalanine in 28 studies
*Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific. [MeSH]
*Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific. [MeSH]
| Studies (3-o-methyl-6-fluoro-dopa) | Trials (3-o-methyl-6-fluoro-dopa) | Recent Studies (post-2010) (3-o-methyl-6-fluoro-dopa) | Studies (dihydroxyphenylalanine) | Trials (dihydroxyphenylalanine) | Recent Studies (post-2010) (dihydroxyphenylalanine) |
|---|---|---|---|---|---|
| 28 | 1 | 1 | 8,823 | 322 | 833 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 13 (46.43) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Aigner, TG; Cohen, RM; Doudet, DJ; McLellan, CA; Wyatt, RJ | 1 |
| Adams, HR; Aigner, TG; Cohen, RM; Doudet, DJ; Finn, RT; McLellan, CA; Miyake, H; Wyatt, R | 1 |
| Barrio, JR; Grafton, ST; Huang, SC; Melega, WP; Phelps, ME; Satyamurthy, N | 1 |
| Barrio, JR; Grafton, S; Hoffman, JM; Huang, SC; Mazziotta, JC; Melega, WP; Phelps, ME; Satyamurthy, N; Yu, DC | 1 |
| Diksic, M; Dyve, S; Gjedde, A; Guttman, M; Kuwabara, H; Reith, J | 1 |
| Chirakal, R; Firnau, G; Garnett, ES; Nahmias, C; Sood, S | 1 |
| Chirakal, R; Firnau, G; Garnett, ES; Nahmias, C; Wahl, L | 1 |
| Calne, DB; Chan, GL; Hammerstad, JP; Hewitt, KA; Pate, BD; Ruth, TJ | 1 |
| Cumming, P; Gjedde, A; Kuwabara, H; Léger, GC | 1 |
| Chaly, T; Dahl, R; Dhawan, V; Eidelberg, D; Fahn, S; Margouleff, D; Moeller, JR; Patlak, CS; Robeson, W; Takikawa, S | 1 |
| Belakhlef, A; Chaly, T; Dhawan, V; Eidelberg, D; Ishikawa, T; Mandel, F; Margouleff, C; Patlak, C; Robeson, W | 1 |
| Chaly, T; Dahl, JR; Dhawan, V; Eidelberg, D; Ishikawa, T; Mandel, F; Margouleff, C; Robeson, W; Spetsieris, P | 1 |
| Nahmias, C; Wahl, L | 1 |
| Barrio, JR; Huang, SC; Satyamurthy, N; Stout, DB; Yee, RE | 1 |
| Barrio, JR; Farahani, KF; Huang, SC; Phelps, ME; Satyamurthy, N; Shoghi-Jadid, K; Stout, DB; Yee, RE; Yeh, EL | 1 |
| Barrio, JR; Huang, SC; Namavari, M; Satyamurthy, N; Stout, DB; Yee, RE | 1 |
| Fernandez, HH; Friedman, JH | 1 |
| de la Fuente-Fernandez, R; Holden, JE; Ruth, TJ; Sossi, V; Stoessl, AJ | 1 |
| Füchtner, F; Steinbach, J | 1 |
| Alheit, HD; Bergmann, R; Beuthien-Baumann, B; Bredow, J; Burchert, W; Franke, WG; Füchtner, F; Hliscs, R; Johannsen, B; Kotzerke, J; Reiss, G; Steinmeier, R | 1 |
| Bauer, R; Brust, P; Füchtner, F; Ganapathy, V; Herzau, M; Kuwabara, H; Opfermann, T; Stark, H; Steinbach, J; Vorwieger, G; Walter, B | 1 |
| Bergmann, R; Beuthien-Baumann, B; Fuechtner, F; Johannsen, B; Kotzerke, J; Pawelke, B; Pietzsch, J | 1 |
| Bauer, R; Brust, P; Fischer, S; Ganapathy, V; Herzau, M; Hinz, R; Huggel, K; Makrides, V; Opfermann, T; Verrey, F; Weber, W; Wester, HJ | 1 |
| Beuthien-Baumann, B; Bredow, J; Kotzerke, J; Strumpf, A; Zessin, J | 1 |
| Bergmann, R; Fuechtner, F; Haase, C; Hoepping, A; Pietzsch, J | 1 |
| Aalto, S; Brück, A; Forsback, S; Jokinen, P; Parkkola, R; Rinne, JO | 1 |
| Alheit, H; Beuthien-Baumann, B; Füchtner, F; Grabowski, J; Hoepping, A; Kotzerke, J; Oehme, L; Winkler, C | 1 |
| Avram, M; Brandl, F; Cabello, J; Knolle, F; Koutsouleris, N; Leucht, C; Leucht, S; Mustafa, M; Scherr, M; Sorg, C; Ziegler, S | 1 |
1 trial(s) available for 3-o-methyl-6-fluoro-dopa and dihydroxyphenylalanine
| Article | Year |
|---|---|
3-O-methyl-6-[18F]fluoro-L-DOPA and its evaluation in brain tumour imaging.
Topics: Adult; Aged; Body Burden; Brain Neoplasms; Dihydroxyphenylalanine; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Organ Specificity; Radiation Dosage; Radiometry; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tomography, Emission-Computed | 2003 |
27 other study(ies) available for 3-o-methyl-6-fluoro-dopa and dihydroxyphenylalanine
| Article | Year |
|---|---|
Delayed L-phenylalanine infusion allows for simultaneous kinetic analysis and improved evaluation of specific-to-nonspecific fluorine-18-dopa uptake in brain.
Topics: Animals; Brain; Carbidopa; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Macaca mulatta; MPTP Poisoning; Phenylalanine; Time Factors; Tomography, Emission-Computed | 1992 |
Postinjection L-phenylalanine increases basal ganglia contrast in PET scans of 6-18F-DOPA.
Topics: Animals; Basal Ganglia; Carbidopa; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Macaca mulatta; Male; Phenylalanine; Time Factors; Tomography, Emission-Computed | 1991 |
L-6-[18F]fluoro-dopa metabolism in monkeys and humans: biochemical parameters for the formulation of tracer kinetic models with positron emission tomography.
Topics: Adult; Animals; Blood Chemical Analysis; Brain; Carbidopa; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Macaca nemestrina; Male; Tissue Distribution; Tomography, Emission-Computed | 1991 |
Kinetics and modeling of L-6-[18F]fluoro-dopa in human positron emission tomographic studies.
Topics: Adult; Brain; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Models, Biological; Time Factors; Tomography, Emission-Computed | 1991 |
Blood-brain transfer and metabolism of 6-[18F]fluoro-L-dopa in rat.
Topics: Animals; Blood-Brain Barrier; Brain; Decarboxylation; Dihydroxyphenylalanine; Dopa Decarboxylase; Fluorine Radioisotopes; Linear Models; Models, Neurological; Rats; Rats, Inbred Strains | 1990 |
Metabolites of 6-[18F]fluoro-L-dopa in human blood.
Topics: Adult; Dihydroxyphenylalanine; Dopamine; Fluorine Radioisotopes; Homovanillic Acid; Humans; Middle Aged | 1988 |
The distribution and kinetics of [18F]6-fluoro-3-O-methyl-L-dopa in the human brain.
Topics: Adult; Brain; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Male; Middle Aged; Models, Neurological; Time Factors; Tissue Distribution | 1994 |
The transport of L-6-fluorodopa and its metabolites from blood to cerebrospinal fluid and brain.
Topics: Amino Acids; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; Dihydroxyphenylalanine; Fluorine Radioisotopes; Homovanillic Acid; Macaca fascicularis; Male; Phenylalanine; Tomography, Emission-Computed | 1993 |
Pharmacokinetics of plasma 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine ([18F]Fdopa) in humans.
Topics: Adult; Arteries; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Parkinson Disease; Reference Values; Tomography, Emission-Computed | 1993 |
Striatal 18F-dopa uptake: absence of an aging effect.
Topics: Adult; Aged; Aging; Corpus Striatum; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Reference Values; Tomography, Emission-Computed | 1993 |
Combined FDOPA and 3OMFD PET studies in Parkinson's disease.
Topics: Adult; Blood-Brain Barrier; Brain; Case-Control Studies; Corpus Striatum; Decarboxylation; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Models, Biological; Parkinson Disease; Time Factors; Tomography, Emission-Computed | 1996 |
Clinical significance of striatal DOPA decarboxylase activity in Parkinson's disease.
Topics: Brain; Case-Control Studies; Corpus Striatum; Dihydroxyphenylalanine; Dopa Decarboxylase; Female; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Models, Biological; Parkinson Disease; Tomography, Emission-Computed | 1996 |
Modeling of fluorine-18-6-fluoro-L-Dopa in humans.
Topics: Adult; Biological Transport; Blood-Brain Barrier; Case-Control Studies; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Fluorine Radioisotopes; Humans; Male; Middle Aged; Models, Biological; Parkinson Disease; Time Factors; Tomography, Emission-Computed | 1996 |
Distribution volume of radiolabeled large neutral amino acids in brain tissue.
Topics: Amino Acids; Animals; Blood-Brain Barrier; Brain; Dihydroxyphenylalanine; Models, Cardiovascular; Models, Neurological; Tissue Distribution | 1998 |
Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution of volume of 30MFD: a PET investigation using non-human primates.
Topics: Animals; Cercopithecus; Cerebellum; Corpus Striatum; Dihydroxyphenylalanine; Kinetics; Models, Biological; Saimiri; Tomography, Emission-Computed | 2000 |
Distribution volume of 3-O-methyl-6.
Topics: Amino Acids, Neutral; Animals; Blood-Brain Barrier; Brain; Cerebellum; Corpus Striatum; Dihydroxyphenylalanine; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed | 2000 |
18F-Dopa vs dopamine transporter ligands in positron emission tomographic and single-photon emission computed tomographic scans for Parkinson disease.
Topics: Dihydroxyphenylalanine; Dopamine Plasma Membrane Transport Proteins; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Parkinson Disease; Tomography, Emission-Computed; Tomography, X-Ray Computed | 2002 |
Effect of dopamine loss and the metabolite 3-O-methyl-[18F]fluoro-dopa on the relation between the 18F-fluorodopa tissue input uptake rate constant Kocc and the [18F]fluorodopa plasma input uptake rate constant Ki.
Topics: Adult; Aged; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Parkinson Disease; Reference Values; Severity of Illness Index | 2003 |
Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA.
Topics: Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Fluorine Radioisotopes; Hydrolysis; Isotope Labeling; Quality Control; Radiopharmaceuticals; Stereoisomerism; Tomography, Emission-Computed | 2003 |
The influx of neutral amino acids into the porcine brain during development: a positron emission tomography study.
Topics: Aging; Amino Acids, Neutral; Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Brain Chemistry; Dihydroxyphenylalanine; Down-Regulation; Enzyme Inhibitors; Kinetics; Large Neutral Amino Acid-Transporter 1; Metabolic Clearance Rate; Models, Biological; Nerve Tissue Proteins; Positron-Emission Tomography; Sus scrofa | 2004 |
3-O-methyl-6-18F-fluoro-L-dopa, a new tumor imaging agent: investigation of transport mechanism in vitro.
Topics: Amino Acids; Amino Acids, Cyclic; Aminoisobutyric Acids; Animals; Biological Transport; Dihydroxyphenylalanine; Endothelial Cells; Fluorine Radioisotopes; HT29 Cells; Humans; Rats; Serine; Sodium; Tumor Cells, Cultured | 2004 |
Preferred transport of O-(2-[18F]fluoroethyl)-D-tyrosine (D-FET) into the porcine brain.
Topics: Adult; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Neoplasms; Contrast Media; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Positron-Emission Tomography; Stereoisomerism; Swine; Tissue Distribution; Tyrosine | 2007 |
Diagnostic impact of PET with 18F-FDG, 18F-DOPA and 3-O-methyl-6-[18F]fluoro-DOPA in recurrent or metastatic medullary thyroid carcinoma.
Topics: Adult; Aged; Carcinoma, Medullary; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radionuclide Imaging; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thyroid Neoplasms | 2007 |
L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Amino Acid Transport System L; Amino Acid Transport Systems, Basic; Animals; Carcinoma, Squamous Cell; Dihydroxyphenylalanine; Fluorine Radioisotopes; Fusion Regulatory Protein-1; HT29 Cells; Humans; Large Neutral Amino Acid-Transporter 1; Male; Mice; Neoplasm Transplantation; RNA, Messenger; Transplantation, Heterologous; Tumor Cells, Cultured | 2007 |
Impaired cognitive performance in Parkinson's disease is related to caudate dopaminergic hypofunction and hippocampal atrophy.
Topics: Aged; Analysis of Variance; Atrophy; Caudate Nucleus; Cognition Disorders; Dihydroxyphenylalanine; Dopamine; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Statistics, Nonparametric | 2009 |
Radiation treatment planning in brain tumours: potential impact of 3-O-methyl-6-[(18)F]fluoro-L-DOPA and PET.
Topics: Biopsy; Brain Neoplasms; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Glioma; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiotherapy Planning, Computer-Assisted; Tomography, X-Ray Computed | 2008 |
Aberrant striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia.
Topics: Adult; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Positron-Emission Tomography; Radiopharmaceuticals; Schizophrenia; Thalamus | 2020 |