3-nitrotyrosine and nitroxyl

3-nitrotyrosine has been researched along with nitroxyl* in 2 studies

Other Studies

2 other study(ies) available for 3-nitrotyrosine and nitroxyl

Article	Year
Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams. Scientific reports, 2016, 08-31, Volume: 6 Ultra-short proton pulses originating from laser-plasma accelerators can provide instantaneous dose rates at least 10(7)-fold in excess of conventional, continuous proton beams. The impact of such extremely high proton dose rates on A549 human lung cancer cells was compared with conventionally accelerated protons and 90 keV X-rays. Between 0.2 and 2 Gy, the yield of DNA double strand breaks (foci of phosphorylated histone H2AX) was not significantly different between the two proton sources or proton irradiation and X-rays. Protein nitroxidation after 1 h judged by 3-nitrotyrosine generation was 2.5 and 5-fold higher in response to conventionally accelerated protons compared to laser-driven protons and X-rays, respectively. This difference was significant (p < 0.01) between 0.25 and 1 Gy. In conclusion, ultra-short proton pulses originating from laser-plasma accelerators have a similar DNA damaging potential as conventional proton beams, while inducing less immediate nitroxidative stress, which probably entails a distinct therapeutic potential. Topics: A549 Cells; DNA; DNA Breaks, Double-Stranded; Dose-Response Relationship, Radiation; Histones; Humans; Lasers; Nitrogen Oxides; Phosphorylation; Protons; Relative Biological Effectiveness; Tyrosine	2016
[Determination of nitrotyrosine with catalytic spectrophotometry combining the substitution of nitroxyl by iodide]. Guang pu xue yu guang pu fen xi = Guang pu, 2002, Volume: 22, Issue:4 The nitroxyl of nitrotyrosine can be substituted quantitatively by iodide when the nitroxyl is reduced to amino and then diazotized to diazonium. The iodide can be determined by catalytic spectrophotometric method with iodide-nitrous acid-arsenious acid system. Thus, a new catalytic spectrophotometric method combining the substitution of nitroxyl by iodide for the determination of nitrotyrosine has been established. The limit of detection is 0.002 mumol.L-1 and the linear range is 0.005-0.25 mumol.L-1. The method has been used for the determination of nitrotyrosine in the products of the reaction of tyrosine with peroxynitrite and the results are satisfactory. Topics: Catalysis; Iodides; Iodine; Nitrogen Oxides; Sensitivity and Specificity; Spectrophotometry; Tyrosine	2002

Article

Year

Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams.

Scientific reports, 2016, 08-31, Volume: 6

Ultra-short proton pulses originating from laser-plasma accelerators can provide instantaneous dose rates at least 10(7)-fold in excess of conventional, continuous proton beams. The impact of such extremely high proton dose rates on A549 human lung cancer cells was compared with conventionally accelerated protons and 90 keV X-rays. Between 0.2 and 2 Gy, the yield of DNA double strand breaks (foci of phosphorylated histone H2AX) was not significantly different between the two proton sources or proton irradiation and X-rays. Protein nitroxidation after 1 h judged by 3-nitrotyrosine generation was 2.5 and 5-fold higher in response to conventionally accelerated protons compared to laser-driven protons and X-rays, respectively. This difference was significant (p < 0.01) between 0.25 and 1 Gy. In conclusion, ultra-short proton pulses originating from laser-plasma accelerators have a similar DNA damaging potential as conventional proton beams, while inducing less immediate nitroxidative stress, which probably entails a distinct therapeutic potential.

Topics: A549 Cells; DNA; DNA Breaks, Double-Stranded; Dose-Response Relationship, Radiation; Histones; Humans; Lasers; Nitrogen Oxides; Phosphorylation; Protons; Relative Biological Effectiveness; Tyrosine

2016

[Determination of nitrotyrosine with catalytic spectrophotometry combining the substitution of nitroxyl by iodide].

Guang pu xue yu guang pu fen xi = Guang pu, 2002, Volume: 22, Issue:4

The nitroxyl of nitrotyrosine can be substituted quantitatively by iodide when the nitroxyl is reduced to amino and then diazotized to diazonium. The iodide can be determined by catalytic spectrophotometric method with iodide-nitrous acid-arsenious acid system. Thus, a new catalytic spectrophotometric method combining the substitution of nitroxyl by iodide for the determination of nitrotyrosine has been established. The limit of detection is 0.002 mumol.L-1 and the linear range is 0.005-0.25 mumol.L-1. The method has been used for the determination of nitrotyrosine in the products of the reaction of tyrosine with peroxynitrite and the results are satisfactory.

Topics: Catalysis; Iodides; Iodine; Nitrogen Oxides; Sensitivity and Specificity; Spectrophotometry; Tyrosine

2002