Compounds > 3-n-methylspiperone
Page last updated: 2024-09-03

3-n-methylspiperone and spiperone

3-n-methylspiperone has been researched along with spiperone in 147 studies

Compound Research Comparison

Studies
(3-n-methylspiperone)		Trials
(3-n-methylspiperone)		Recent Studies (post-2010)
(3-n-methylspiperone)		Studies
(spiperone)		Trials
(spiperone)		Recent Studies (post-2010) (spiperone)
155672,9441385

Protein Interaction Comparison

ProteinTaxonomy3-n-methylspiperone (IC50)spiperone (IC50)
Bile salt export pumpHomo sapiens (human)10
D(2) dopamine receptorHomo sapiens (human)0.0008
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.097
D(4) dopamine receptorHomo sapiens (human)0.0005
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.097
Histamine H1 receptorCavia porcellus (domestic guinea pig)0.097
D(3) dopamine receptorHomo sapiens (human)0.0635
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.097
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0001
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.955

Research

Studies (147)

TimeframeStudies, this research(%)All Research%
pre-199040 (27.21)18.7374
1990's88 (59.86)18.2507
2000's15 (10.20)29.6817
2010's4 (2.72)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ehrenkaufer, RL; Ivins, KJ; Jackson, JR; Luedtke, RR; Mach, RH; Molinoff, PB1
Billings, J; Kung, HF; Kung, MP; Murphy, RA1
Guo, YZ; Kasliwal, R; Kung, HF; Kung, MP; Mach, RH; Pan, SG1
Kristiansen, K; Kroeze, WK; Roth, BL; Shapiro, DA1
Ido, T; Iwata, R; Pascali, C; Takahashi, T; Yanai, K; Yuasa, M1
Meltzer, HY; Stockmeier, CA1
Iyo, M1
Ido, T; Iwata, R; Ryu, JH; Watanabe, T; Yanai, K1
Wong, DF1
Ehrenkaufer, RL; Giandinoto, S; Klam, S; Makoroff, K; Moroney, D; Morton, T; Nowak, P1
Bendriem, B; Dewey, SL; Fowler, JS; Hitzemann, R; Logan, J; Raulli, R; Schlyer, DJ; Shiue, CY; Volkow, ND; Wolf, AP1
Inoue, O; Itoh, T; Suhara, T; Tsukada, H; Yamasaki, T; Yonezawa, H1
Fukuda, H; Inoue, O; Itoh, T; Iyo, M; Nishio, M; Shinotoh, H; Suhara, T; Tohgi, H; Yamasaki, T; Yonezawa, H1
Coppens, HJ; Korf, J; Paans, AM; Slooff, CJ; Vaalburg, W; Wiegman, T1
Inoue, O; Itoh, T; Kobayashi, K; Langstrom, B; Tsukada, H1
Inoue, O; Itoh, T; Kobayashi, K; Suhara, T; Tsukada, H1
Angrist, B; Brodie, JD; Dewey, SL; Fowler, JS; Gatley, SJ; Logan, J; Volkow, ND; Wolf, AP1
Inoue, O; Itoh, T; Långström, B; Suhara, T; Tohgi, H; Tsukada, H; Yamasaki, T; Yonezawa, H1
Chen, C; Goldman, S; Matsumura, K; Minkin, E; Scheffel, U; Wagner, HN; Wong, DF; Young, LT1
Coenen, HH; Hamacher, K; Heiss, WD; Herholz, K; Huber, M; Karbe, H; Lövenich, A; Stöcklin, G; Wienhard, K1
Inoue, O; Langstrom, B; Suhara, T; Tsukada, H; Yonezawa, H1
Barton, AC; Monsma, FJ; Sibley, DR1
Korf, J; Paans, AM; Swart, JA; Vaalburg, W; van der Werf, JF; Wiegman, T1
Dijkstra, HA; Korf, J; Swart, JA1
Inoue, O; Mikado, F; Suzuki, K; Tamate, K1
Farde, L; Hall, H; Halldin, C; Kopp, J; Wedel, I1
Alexoff, DL; Brodie, JD; Dewey, SL; Fowler, JS; King, PT; MacGregor, RR; Schlyer, DJ; Shiue, CY; Volkow, ND; Wolf, AP1
Långström, B1
Anders, P; Brandt, J; Dannals, RF; Folstein, SE; Links, J; McDonnell-Sill, A; Starkstein, S; Strauss, ME; Tune, LE; Wong, DF1
Angrist, B; Brodie, JD; Dewey, SL; Fowler, JS; Logan, J; Volkow, ND; Wolf, AP1
Allen, CN; Bigornia, L; Jan, CR; Lyon, RA; Schneider, AS; Titeler, M1
Nowak, JZ; Schorderet, M1
Inoue, O; Kobayasi, K; Suhara, T1
Alpert, R; Bendriem, B; Christman, D; Dewey, SL; Fowler, JS; Logan, J; Schlyer, D; Shiue, CY; Volkow, ND; Wolf, AP1
Barton, AC; Brassard, DL; Haugland, RP; Kang, HC; Monsma, FJ; Sibley, DR1
Fukuda, H; Inoue, O; Ito, T; Iyo, M; Koseki, A; Nishio, M; Shinotoh, H; Suzuki, K; Yamasaki, T; Yonezawa, H1
Dannals, RF1
Barouche, F; Brodie, JD; Cooper, TB; Fowler, JS; Rotrosen, J; Shiue, CY; Wolf, AP; Wolkin, A1
Brassard, DL; Monsma, FJ; Sibley, DR1
Broussolle, EP; Dannals, RF; Gjedde, A; Kuhar, MJ; Links, JM; Malat, J; O'Tuama, LA; Pearlson, GD; Ravert, HT; Snyder, SH; Tamminga, CA; Toung, JK; Tune, LE; Wagner, HN; Williams, JA; Wilson, AA; Wong, DF1
Drew, KL; Glick, SD; Lyon, RA; Titeler, M1
Gjedde, A; Wagner, HN; Wong, DF1
Dannals, RF; Douglass, KH; Gjedde, A; Kuhar, MJ; Links, JM; Wagner, HN; Wong, DF1
Dannals, RF; Frost, JJ; Kuhar, MJ; Links, JM; Lyon, RA; Titeler, M; Wagner, HN; Whitehouse, PJ; Wong, DF1
Aquilonius, SM; Bergström, K; Eckernäs, SA; Hägglund, J; Hartvig, P; Långström, B; Lundqvist, H; Malmborg, P; Någren, K1
Aquilonius, SM; Eckernäs, SA; Gullberg, P; Hägglund, J; Hartvig, P; Långström, B; Lundquist, H1
Billings, JJ; Guo, YZ; Kung, HF; Mach, RH1
Arnett, CD; Barouche, F; Brodie, JD; Fowler, JS; MacGregor, RR; Russell, JA; Shiue, CY; Smith, M; Wolf, AP; Wolkin, A1
Andreasen, NC; Carson, R; Diksic, M; Evans, A; Farde, L; Gjedde, A; Hakim, A; Lal, S; Nair, N; Sedvall, G1
Burns, HD; Dannals, RF; Frost, JJ; Kuhar, MJ; Links, JM; Ravert, HT; Snyder, SH; Wagner, HN; Wilson, AA; Wong, DF1
Wagner, HN2
Dannals, RF; Ravert, HT; Wagner, HN; Wilson, AA1
Batshaw, ML; Dannals, RF; Harris, JC; Links, JM; Moser, HW; Naidu, S; Rett, A; Wagner, HN; Wong, DF1
Leenders, KL1
Axelsson, S; Eckernäs, SA; Ekblom, B; Fasth, KJ; Gullberg, P; Hartvig, P; Långström, B; Lindström, L; Lundqvist, H1
Frackowiak, RS; Leenders, KL; Marsden, CD; Quinn, N1
Bolduc, P; Dannals, RF; Links, JM; Mayberg, HS; Parikh, R; Price, T; Robinson, RG; Starkstein, SE; Wilson, AA; Wong, DF1
Hatazawa, J; Ido, T; Ishiwata, K; Ito, M; Matsuzawa, T; Takahashi, T; Ujiie, A; Watanuki, S; Yanai, K1
Arnett, CD; Christman, DR; Fowler, JS; MacGregor, RR; Shiue, CY; Smith, MR; Wolf, AP1
Fowler, JS; MacGregor, RR; Schlyer, DJ; Shiue, CY; Wolf, AP1
Aquilonius, SM; Eckernäs, SA; Hägglund, J; Hartvig, P; Långström, B; Lundqvist, H; Någren, K1
Korf, J; Lakke, JP; Paans, AM; Rutgers, AW; Vaalburg, W1
Arnett, CD; Fowler, JS; McPherson, DW; Shiue, CY; Wolf, AP; Zecca, L1
Arnett, CD; Fowler, JS; Halldin, C; Långström, B; MacGregor, RR; Shiue, CY; Wagner, HN; Wolf, AP1
Bigornia, L; Lyon, RA; Schneider, AS; Titeler, M1
Dannals, RF; Frost, JJ; Kuhar, MJ; Smith, AC; Wagner, HN1
Arnett, CD; Fowler, JS; McPherson, DW; Shiue, CY; Wolf, AP1
Bjorvvinssen, E; Dannals, RF; Kuhar, MJ; Links, JM; Pearlson, G; Ravert, HT; Suneja, S; Wagner, HN; Wilson, AA; Wong, DF1
Iio, M; Inoue, O; Nishihara, Y; Omokawa, H; Tanaka, A; Yamazaki, T1
Burns, HD; Dannals, RF; Duelfer, T; Frost, JJ; Kuhar, MJ; Langström, B; Ravert, HT; Wagner, HN; Wong, DF; Zemyan, SE1
Burns, HD; Dannals, RF; Duelfer, T; Frost, JJ; Kramer, AV; Kuhar, MJ; Langstrom, B; Links, JM; Lukas, SE; Ravert, HT; Rosenbloom, SB; Wagner, HN; Wong, DF1
Burns, HD; Dannals, RF; Duelfer, T; Frost, JJ; Langström, B; Links, JM; Ravert, HT; Rosenbloom, SB; Wagner, HN; Wong, DF1
Gjedde, A; Reith, J; Wong, D1
Fowler, JS; Gur, RC; Hitzemann, RJ; Logan, J; MacGregor, RR; Schlyer, D; Volkow, ND; Wang, GJ; Wolf, AP1
Eriksson, L; Farde, L; Halldin, C; Nordström, AL1
Farde, L; Halldin, C; Karlsson, P; Nordström, AL; Nyberg, S; Sedvall, G1
Anderson, JL1
Brodie, JD; Fowler, JS; Schlyer, DJ; Smith, MR; Volkow, ND; Wang, GJ; Warner, D; Wolf, AP; Yousef, KA1
Gonzalez, AM; Sibley, DR1
Cohen, D; Ehrenkaufer, RL; Evora, PH; Greenberg, JH; Luedtke, RR; Mach, RH; Morton, TE; Nowak, PA; Reivich, M; Shao, L1
Farde, L; Halldin, C; Nordström, AL1
Engelbrecht, V; Hefter, H; Nebeling, B; Schlaug, G; Seitz, RJ; Stöcklin, G; Weiss, P1
Inoue, O; Itoh, T; Mataga, N; Onoe, H; Suzuki, K; Tsukada, H; Watanabe, Y1
Dannals, RF; Pearlson, G; Ravert, HT; Sapp, J; Shaya, EK; Strauss, M; Tune, LE; Wilson, AA; Wong, DF; Young, T1
Grünewald, S; Maul, G; Michel, H; Reiländer, H; Sander, P1
Dewey, SL; Fowler, JS; Hitzemann, R; Logan, J; Schlyer, DJ; Volkow, ND; Wang, GJ; Wolf, AP1
Almay, B; Eckernäs, SA; Forsgren, L; Hartvig, P; Holmgren, G; Långström, B; Leenders, K; Lundqvist, H1
DiCarlo, JJ; Meltzer, HY; Stockmeier, CA; Thompson, P; Zhang, Y1
Fukuda, H; Fukui, S; Itoh, T; Iyo, M; Nishio, M; Suzuki, K; Tateno, Y; Yamasaki, T1
Gatley, SJ1
Fowler, JS; Hitzemann, RJ; MacGregor, RR; Schlyer, DJ; Shea, CE; Volkow, ND; Wang, GJ; Wolf, AP1
Inoue, Y; Momose, T; Nishikawa, J; Sasaki, Y; Teramoto, A; Watanabe, T1
Iyo, M; Yamasaki, T1
Ehrenkaufer, RL; Jackson, JR; Mach, RH; Moroney, DA; Morton, TE; Nowak, PA1
Chen, J; Fu, D; Javitch, JA2
Ballesteros, JA; Chen, J; Fu, D; Javitch, JA; Weinstein, H1
Fowler, JS; Gatley, SJ; Hitzemann, R; Logan, J; MacGregor, RR; Schlyer, DJ; Volkow, ND; Wang, GJ; Wolf, AP1
Arnold, S; Engelbrecht, V; Hefter, H; Kuwert, T; Schlaug, G; Seitz, RJ; Stöcklin, G1
Cravchik, A; Gejman, PV; Sibley, DR1
Futatsubashi, M; Kakiuchi, T; Kreek, MJ; Kreuter, J; Maggos, CE; Nishiyama, S; Tsukada, H; Unterwald, EM1
Dannals, RF; Kao, PF; Kim, S; Lever, JR; Ravert, HT; Wagner, HN1
Grünewald, S; Michel, H; Reiländer, H1
Inoue, O; Kobayashi, K; Långström, B; Onoe, H; Watanabe, Y1
Berridge, MS; Compton-Toth, BA; Goyer, PF; Meltzer, HY; Miraldi, F; Morris, ED; Schulz, SC; Semple, WE; Wong, DF1
Momose, T; Sasaki, Y1
Gjedde, A; Meltzer, CC; Wilson, PD; Wong, DF; Young, D1
Dannals, RF; Gjedde, A; Kuhar, MJ; Meltzer, CC; Pearlson, GD; Ravert, HT; Reith, J; Tune, LE; Wong, DF; Young, LT1
Cravchik, A; Gejman, PV; Hietala, J; Någren, K; Pohjalainen, T; Rinne, J; Syvälahti, E1
Brandt, J; Brown, J; Chen, C; Dannals, RF; Gjedde, A; Kimball, AW; Ravert, HT; Shaya, E; Singer, HS; Wagner, HN; Wilson, PD; Wong, DF1
Conley, RR; Tamminga, CA1
Dannals, RF; Gründer, G; Howard, DR; Offord, SJ; Ravert, HT; Salzmann, JK; Szymanski, S; Wilson, PD; Wong, DF; Yokoi, F1
Bjurling, P; Fasth, KJ; Hartvig, P; Långström, B; Tedroff, J; Torstenson, R; Watanabe, Y1
Kakiuchi, T; Kosugi, T; Kreek, MJ; Nishiyama, S; Tsukada, H; Unterwald, EM1
Ballesteros, JA; Chen, J; Javitch, JA; Weinstein, H1
Ho, A; Kakiuchi, T; Kreek, MJ; Kreuter, J; Maggos, CE; Myers, JE; Nishiyama, S; Schlussman, SD; Tsukada, H; Unterwald, EM1
Hosoi, R; Inoue, O; Kobayashi, K; Nakano, T; Nishimura, T; Wakahara, S; Watanabe, Y1
Bergström, M; Gefvert, O; Hagberg, G; Långström, B; Lindström, L; Wiesel, FA; Wieselgren, IM1
Gee, A; Hosoi, R; Inoue, O; Kobayashi, K2
Haida, M; Kozuma, R; Shinohara, Y; Takagi, S; Takahashi, W; Yoshii, F1
Brown, C; Klein-Stevens, CL; Liang, L; White, J; Zhu, N1
Chu, A; Schetz, JA; Sibley, DR1
Conklin, DS; Fitzgerald, LW; Hartig, PR; Iyer, G; Kostich, WA; Krause, CM; Largent, BL; Marshall, AP; Patterson, JP; Tran, DP1
Gee, A; Inoue, O; Kobayashi, K; Wakahara, S1
Eriksson, B; Farde, L; Halldin, C; Nyberg, S; Oxenstierna, G1
Endo, K; Hayakawa, N; Ishiwata, K; Oda, K; Ogi, N; Senda, M; Tanaka, A; Toyama, H1
Kaasinen, V; Lehikoinen, P; Någren, K; Oikonen, V; Rinne, JO; Ruottinen, HM1
Gee, A; Hosoi, R; Inoue, O; Kobayashi, K; Yamaguchi, M1
Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M1
Inoue, O; Iyo, M; Kobayashi, K; Matsushima, E; Okubo, Y; Sassa, T; Someya, Y; Sudo, Y; Suhara, T; Suzuki, K; Tateno, Y; Terasaki, O; Toru, M1
Bender, D; Cumming, P; Danielsen, E; Gjedde, A; Hansen, SB; Ishizu, K; Smith, DF; Wong, DF1
Dewey, SL; Fowler, JS; Gatley, SJ; Logan, J; Volkow, ND1
DeJesus, OT; Gatley, SJ; Gifford, AN; Huemmer, CL; Rice, OV; Rogoz, R; Shen, J; Volkow, ND1
Endo, K; Hayakawa, N; Ishiwata, K; Nagaoka, T; Oda, K; Ogi, N; Senda, M; Tanaka, A; Toyama, H; Umegaki, H1
Imafuku, I; Iso-o, N; Kanazawa, I; Kwak, S; Momose, T; Shirouzu, I; Yamamoto, T; Yoshimura, M1
Gee, A; Hosoi, R; Inoue, O; Ishikawa, M; Kobayashi, K; Yamaguchi, M1
Cumming, P; Gjedde, A; Jensen, SB; Munk, OL; Olsen, AK; Rosa-Neto, P; Watanabe, H1
Iwata, Y; Minabe, Y; Mori, N; Nakamura, K; Okada, H; Ouchi, Y; Sekine, Y; Sugihara, G; Suzuki, K; Takei, N; Tsuchiya, KJ; Yoshikawa, E1
Hideyama, T; Kwak, S; Momose, T; Shimizu, J; Tsuji, S1
Fang, S; Shen, G; Tian, M; Yang, X; Zhang, H; Zhao, C; Zheng, X1
Butterworth, RF; Kato, A; Sasaki, T; Sawara, K; Sera, K; Suzuki, K; Terasaki, K; Watanabe, Y1
Ishibashi, K; Ishii, K; Ishiwata, K; Mizusawa, H; Oda, K1
Halldin, C; Hong, J; Innis, RB; Liow, JS; Pike, VW; Seneca, N; Sibley, DR; Skinbjerg, M; Weinshenker, D1
Chao, F; Chen, Q; Du, F; Hu, Y; Tian, M; Zhang, H; Zhang, Y1
Chao, F; Chen, L; Chen, Q; Chung, JK; Du, F; Hou, H; Shen, Y; Tian, M; Wu, S; Zhang, H; Zhang, Y1

Reviews

6 review(s) available for 3-n-methylspiperone and spiperone

ArticleYear
Design of molecules labeled with beta+ emitters for use in multitracer investigations using positron emission tomography.
    Acta radiologica. Supplementum, 1990, Volume: 374

    Topics: Beta Particles; Humans; Isotope Labeling; Levodopa; Methionine; Neurotransmitter Agents; Nomifensine; Raclopride; Salicylamides; Spiperone; Tomography, Emission-Computed

1990
Retinal dopamine D1 and D2 receptors: characterization by binding or pharmacological studies and physiological functions.
    Cellular and molecular neurobiology, 1990, Volume: 10, Issue:3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Arylamine N-Acetyltransferase; Benzazepines; Colforsin; Cyclic AMP; Dopamine; Ergolines; Light; Quinpirole; Receptors, Dopamine; Retina; Second Messenger Systems; Species Specificity; Spiperone; Sulpiride; Vertebrates

1990
Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
    Schizophrenia bulletin, 1988, Volume: 14, Issue:3

    Topics: Adult; Corpus Striatum; Haloperidol; Humans; National Institute of Mental Health (U.S.); Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; United States

1988
Imaging neuroreceptors in the human brain in health and disease.
    Radioisotopes, 1985, Volume: 34, Issue:2

    Topics: Adult; Age Factors; Aged; Brain; Brain Diseases; Butyrophenones; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Sensory Receptor Cells; Sex Factors; Spiperone; Tomography, Emission-Computed

1985
[Striatal dopamine D2 receptor in Parkinson disease and its related disorders assessed by C-11 NMSP and PET].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:1

    Topics: Aging; Biomarkers; Carbon Radioisotopes; Corpus Striatum; Diagnosis, Differential; Dopamine Agonists; Humans; Parkinson Disease; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1997
The application of neuroimaging techniques to drug development.
    The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 10

    Topics: Antipsychotic Agents; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebrovascular Circulation; Deoxyglucose; Diagnostic Imaging; Drug Industry; Drugs, Investigational; Fluorodeoxyglucose F18; Haloperidol; Humans; Ketamine; Magnetic Resonance Imaging; Mental Disorders; Neuropharmacology; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

1997

Trials

6 trial(s) available for 3-n-methylspiperone and spiperone

ArticleYear
High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET.
    Psychopharmacology, 1993, Volume: 110, Issue:3

    Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agonists; Female; Humans; Male; Middle Aged; Prefrontal Cortex; Psychotic Disorders; Raclopride; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed

1993
Neurological impairment and recovery in Wilson's disease: evidence from PET and MRI.
    Journal of the neurological sciences, 1996, Volume: 136, Issue:1-2

    Topics: Adult; Brain Chemistry; Chelating Agents; Deoxyglucose; Female; Fluorodeoxyglucose F18; Glucose; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Neostriatum; Nervous System; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1996
N-[11C]methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic.
    Psychiatry research, 1998, Jun-30, Volume: 82, Issue:3

    Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Cerebellum; Dibenzothiazepines; Dopamine; Dose-Response Relationship, Drug; Humans; Male; Putamen; Quetiapine Fumarate; Raclopride; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed

1998
Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.
    The American journal of psychiatry, 1999, Volume: 156, Issue:6

    Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorine Radioisotopes; Humans; Male; Psychiatric Status Rating Scales; Raclopride; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; Treatment Outcome

1999
Perospirone is a new generation antipsychotic: evidence from a positron emission tomography study of serotonin 2 and D2 receptor occupancy in the living human brain.
    Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:5

    Topics: Adult; Antipsychotic Agents; Binding, Competitive; Brain; Humans; Indoles; Isoindoles; Male; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Reference Values; Spiperone; Thiazoles

2006
Frightening music triggers rapid changes in brain monoamine receptors: a pilot PET study.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:10

    Topics: Adult; Brain; Carbon Radioisotopes; Fear; Humans; Male; Music; Pilot Projects; Positron-Emission Tomography; Receptors, Biogenic Amine; Spiperone; Time Factors; Young Adult

2012

Other Studies

135 other study(ies) available for 3-n-methylspiperone and spiperone

ArticleYear
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Alkylation; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Structure-Activity Relationship

1992
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Benzofurans; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; Iodine Radioisotopes; Isotope Labeling; Male; Molecular Structure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tissue Distribution

1990
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:5

    Topics: Animals; Benzamides; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Iodine Radioisotopes; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship

1988
Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.
    Molecular pharmacology, 2000, Volume: 58, Issue:5

    Topics: Amino Acid Substitution; Animals; Binding, Competitive; Conserved Sequence; COS Cells; DOM 2,5-Dimethoxy-4-Methylamphetamine; Hydrolysis; Membrane Proteins; Models, Molecular; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Folding; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Signal Transduction; Tryptamines

2000
On-line [11C]methylation using [11C]methyl iodide for the automated preparation of 11C-radiopharmaceuticals.
    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1992, Volume: 43, Issue:9

    Topics: Benztropine; Carbon Radioisotopes; Cyproheptadine; Doxepin; Hydrocarbons, Iodinated; Isotope Labeling; Methylation; Spiperone

1992
In vivo occupancy of dopamine receptors by antipsychotic drugs.
    Archives of general psychiatry, 1992, Volume: 49, Issue:7

    Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Humans; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone

1992
PET dopamine D2 receptors and susceptibility to methamphetamine psychosis.
    Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A

    Topics: Adult; Brain; Brain Chemistry; Dopamine Agents; Humans; Male; Methamphetamine; Psychoses, Substance-Induced; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1992
Receptor autoradiography with 11C and [3H]-labelled ligands visualized by imaging plates.
    Neuroreport, 1992, Volume: 3, Issue:11

    Topics: Animals; Autoradiography; Brain; Dopamine Agents; Dopamine D2 Receptor Antagonists; Guinea Pigs; Histamine Agonists; Histamine Antagonists; Ligands; Male; Methylhistamines; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Histamine; Receptors, Histamine H3; Spiperone; Tomography, Emission-Computed

1992
PET studies of neuroreceptors in schizophrenia. Commentary on "The current status of PET scanning with respect to schizophrenia".
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:1

    Topics: Brain; Carbon Radioisotopes; Dopamine Antagonists; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tritium

1992
Internal-surface reversed-phase chromatography for plasma metabolite analysis of radiopharmaceuticals.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1992, Volume: 19, Issue:6

    Topics: Animals; Blood Proteins; Centrifugation; Chromatography; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Fluorine Radioisotopes; Humans; Papio; Protein Binding; Rats; Rats, Inbred Strains; Spiperone; Tomography, Emission-Computed

1992
Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:1

    Topics: Adult; Animals; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Male; Mice; Schizophrenia; Spiperone; Tomography, Emission-Computed

1992
Effect of lithium and anesthetics on in vivo binding of dopamine receptors.
    Acta radiologica. Supplementum, 1991, Volume: 376

    Topics: Animals; Apomorphine; Benzazepines; Ketamine; Lithium; Male; Mice; Mice, Inbred C3H; Pentobarbital; Rats; Receptors, Dopamine; Spiperone

1991
[Effect of aging on in vivo binding of 11C-N-methylspiperone in living human frontal cortex].
    Kaku igaku. The Japanese journal of nuclear medicine, 1991, Volume: 28, Issue:1

    Topics: Adult; Aged; Aging; Carbon Radioisotopes; Dopamine Agents; Frontal Lobe; Humans; Male; Middle Aged; Spiperone; Tomography, Emission-Computed

1991
High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients.
    Biological psychiatry, 1991, Apr-01, Volume: 29, Issue:7

    Topics: Adult; Antipsychotic Agents; Brain; Dyskinesia, Drug-Induced; Female; Humans; Male; Psychiatric Status Rating Scales; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1991
Difference in in vivo receptor binding between [3H]N-methylspiperone and [3H]raclopride in reserpine-treated mouse brain.
    Journal of neural transmission. General section, 1991, Volume: 85, Issue:1

    Topics: Animals; Cerebellum; Corpus Striatum; Dopamine Agents; Male; Mice; Raclopride; Receptors, Dopamine; Reserpine; Salicylamides; Spiperone

1991
Swim stress alters in vivo binding of [3H]N-methylspiperone.
    Neuropharmacology, 1991, Volume: 30, Issue:10

    Topics: Animals; Cerebellum; Corpus Striatum; Dopamine Agents; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Stress, Psychological; Swimming

1991
Effects of endogenous dopamine on measures of [18F]N-methylspiroperidol binding in the basal ganglia: comparison of simulations and experimental results from PET studies in baboons.
    Synapse (New York, N.Y.), 1991, Volume: 9, Issue:3

    Topics: Amphetamine; Animals; Basal Ganglia; Computer Simulation; Dopamine; Dopamine Agents; Fluorine Radioisotopes; Ligands; Models, Biological; Papio; Pulsatile Flow; Spiperone; Tomography, Emission-Computed

1991
Effect of L-dopa and reserpine on in vivo binding of (3H)-SCH 23390 and (3H)-N-methylspiperone.
    Acta radiologica. Supplementum, 1991, Volume: 376

    Topics: Animals; Benzazepines; Dopamine Agents; Levodopa; Male; Mice; Reserpine; Spiperone; Tritium

1991
Effects of endogenous dopamine on kinetics of [3H]N-methylspiperone and [3H]raclopride binding in the rat brain.
    Synapse (New York, N.Y.), 1991, Volume: 9, Issue:3

    Topics: Amphetamine; Animals; Brain; Dopamine; Dopamine Antagonists; Kinetics; Male; Raclopride; Rats; Reserpine; Salicylamides; Spiperone; Tomography, Emission-Computed; Tritium

1991
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
    Journal of neural transmission. General section, 1991, Volume: 86, Issue:3

    Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tomography, X-Ray Computed

1991
Reserpine-induced reduction of in vivo binding of SCH 23390 and N-methylspiperone and its reversal by d-amphetamine.
    European journal of pharmacology, 1991, May-17, Volume: 197, Issue:2-3

    Topics: Animals; Benzazepines; Cerebellum; Corpus Striatum; Dextroamphetamine; Kinetics; Male; Mice; Receptors, Dopamine; Reserpine; Spiperone

1991
Expression of functional D2 dopamine receptors following differentiation of Y-79 human retinoblastoma cells.
    Journal of neurochemistry, 1990, Volume: 54, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Binding, Competitive; Cell Membrane; Colforsin; Dopamine; Dopamine Agents; Dopamine Antagonists; Eye Neoplasms; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine; Receptors, Dopamine D2; Retinoblastoma; Spiperone; Tumor Cells, Cultured

1990
In vivo binding of spiperone and N-methylspiperone to dopaminergic and serotonergic sites in the rat brain: multiple modeling and implications for PET scanning.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:3

    Topics: Animals; Brain; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Dopamine Agents; Frontal Lobe; Models, Theoretical; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone; Tomography, Emission-Computed; Tritium

1990
Graphical method to determine sigmoid ligand binding in vivo at low doses.
    Journal of pharmacological methods, 1990, Volume: 23, Issue:2

    Topics: Brain; Dopamine Agents; Humans; Kinetics; Ligands; Models, Biological; Receptors, Drug; Spiperone; Statistics as Topic; Tomography, Emission-Computed

1990
Production of 3-N-[11C]methylspiperone with high specific activity and high radiochemical purity for PET studies: suppression of its radiolysis.
    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1990, Volume: 41, Issue:6

    Topics: Brain; Brain Chemistry; Carbon Radioisotopes; Dopamine Agents; Humans; Isotope Labeling; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1990
Comparison of the in vitro receptor binding properties of N-[3H]methylspiperone and [3H]raclopride to rat and human brain membranes.
    Journal of neurochemistry, 1990, Volume: 55, Issue:6

    Topics: Animals; Binding, Competitive; Brain; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Humans; Male; Membranes; Putamen; Raclopride; Rats; Salicylamides; Spiperone; Tritium

1990
Positron emission tomography (PET) studies of dopaminergic/cholinergic interactions in the baboon brain.
    Synapse (New York, N.Y.), 1990, Volume: 6, Issue:4

    Topics: Animals; Brain; Corpus Striatum; Dopamine; Dopamine Agents; Female; Fluorine Radioisotopes; Papio; Parasympathetic Nervous System; Spiperone; Tomography, Emission-Computed

1990
D2 receptors in Huntington's disease: positron emission tomography findings and clinical correlates.
    The Journal of neuropsychiatry and clinical neurosciences, 1990,Winter, Volume: 2, Issue:1

    Topics: Adult; Brain; Brain Mapping; Caudate Nucleus; Cerebellum; Dopamine Agents; Female; Humans; Huntington Disease; Male; Neuropsychological Tests; Putamen; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Risk Factors; Spiperone; Tomography, Emission-Computed

1990
Amphetamine induced decreases in (18F)-N-methylspiroperidol binding in the baboon brain using positron emission tomography (PET).
    Synapse (New York, N.Y.), 1991, Volume: 7, Issue:4

    Topics: Animals; Brain; Dextroamphetamine; Fluorine Radioisotopes; Papio; Receptors, Dopamine; Reference Values; Spiperone; Tomography, Emission-Computed

1991
D2 dopamine receptors modulate calcium channel currents and catecholamine secretion in bovine adrenal chromaffin cells.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:2

    Topics: Adrenal Glands; Animals; Apomorphine; Calcium; Calcium Channels; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Norepinephrine; Potassium; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone

1990
Effect of desipramine on dopamine receptor binding in vivo.
    Life sciences, 1990, Volume: 47, Issue:23

    Topics: Animals; Antidepressive Agents, Tricyclic; Benzazepines; Cerebellum; Corpus Striatum; Desipramine; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Male; Mice; Receptors, Dopamine; Spiperone

1990
Effects of chronic cocaine abuse on postsynaptic dopamine receptors.
    The American journal of psychiatry, 1990, Volume: 147, Issue:6

    Topics: Adult; Basal Ganglia; Cocaine; Corpus Striatum; Down-Regulation; Fluorine Radioisotopes; Humans; Receptors, Dopamine; Spiperone; Substance-Related Disorders; Tomography, Emission-Computed; Up-Regulation

1990
Characterization of novel fluorescent ligands with high affinity for D1 and D2 dopaminergic receptors.
    Journal of neurochemistry, 1989, Volume: 52, Issue:5

    Topics: Affinity Labels; Animals; Benzazepines; Binding, Competitive; Boron Compounds; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Molecular Structure; Porphobilinogen; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Rhodamines; Spiperone; Thiocyanates; Tritium

1989
[Age-related decrease of 11C-N-methylspiperone in vivo binding to human striatum detected by PET].
    Kaku igaku. The Japanese journal of nuclear medicine, 1989, Volume: 26, Issue:2

    Topics: Adult; Aged; Aging; Cerebellum; Corpus Striatum; Female; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1989
Synthesis of radiotracers.
    The Journal of neuropsychiatry and clinical neurosciences, 1989,Winter, Volume: 1, Issue:1

    Topics: Carbon Radioisotopes; Equipment Design; Female; Humans; Male; Particle Accelerators; Radioactive Tracers; Radioactivity; Radionuclide Generators; Spiperone; Tomography, Emission-Computed

1989
Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia.
    The American journal of psychiatry, 1989, Volume: 146, Issue:7

    Topics: Adolescent; Adult; Cerebellum; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Fluorine Radioisotopes; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed

1989
Identification and characterization of D1 and D2 dopamine receptors in cultured neuroblastoma and retinoblastoma clonal cell lines.
    Brain research, 1989, Jul-17, Volume: 492, Issue:1-2

    Topics: Animals; Benzazepines; Binding, Competitive; Cell Line; Dopamine Antagonists; Humans; Mice; Neuroblastoma; Receptors, Dopamine; Retinoblastoma; Spiperone; Tumor Cells, Cultured

1989
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
    Science (New York, N.Y.), 1986, Dec-19, Volume: 234, Issue:4783

    Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Haloperidol; Humans; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1986
Asymmetry in D-2 binding in female rat striata.
    Brain research, 1986, Jan-15, Volume: 363, Issue:1

    Topics: Animals; Brain Mapping; Corpus Striatum; Dominance, Cerebral; Female; Functional Laterality; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Sex Factors; Spiperone

1986
Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Brain; Caudate Nucleus; Cerebellum; Frontal Lobe; Humans; Kinetics; Ligands; Male; Models, Biological; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Sensory Receptor Cells; Spiperone; Tomography, Emission-Computed

1986
Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Brain; Caudate Nucleus; Haloperidol; Humans; Kinetics; Ligands; Male; Middle Aged; Models, Biological; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Sensory Receptor Cells; Spiperone; Tomography, Emission-Computed

1986
3H-3-N-methylspiperone labels D2 dopamine receptors in basal ganglia and S2 serotonin receptors in cerebral cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1986, Volume: 6, Issue:10

    Topics: Animals; Basal Ganglia; Cerebral Cortex; Humans; Male; Middle Aged; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Tritium

1986
Regional kinetics of [11C]methylspiperone in the brain studied by positron emission tomography in patients with Parkinson's disease.
    Advances in neurology, 1987, Volume: 45

    Topics: Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Humans; Huntington Disease; Kinetics; Parkinson Disease; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed

1987
Dopamine receptor properties in Parkinson's disease and Huntington's chorea evaluated by positron emission tomography using 11C-N-methyl-spiperone.
    Acta neurologica Scandinavica, 1987, Volume: 75, Issue:2

    Topics: Aged; Caudate Nucleus; Corpus Striatum; Female; Frontal Lobe; Humans; Huntington Disease; Kinetics; Male; Parkinson Disease; Putamen; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed

1987
Comparison of in vivo D-2 dopamine receptor binding of IBZM and NMSP in rat brain.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1988, Volume: 15, Issue:2

    Topics: Animals; Benzamides; Brain; Iodine Radioisotopes; Male; Pyrrolidines; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed; Tritium

1988
Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients.
    Biological psychiatry, 1988, Apr-01, Volume: 23, Issue:7

    Topics: Adult; Binding, Competitive; Chlorpromazine; Corpus Striatum; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1988
Radiolabeled drugs as probes of central nervous system neurons.
    Clinical chemistry, 1985, Volume: 31, Issue:9

    Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Female; Fentanyl; Forecasting; Humans; Isotope Labeling; Male; Middle Aged; Neurons; Receptors, Dopamine; Receptors, Opioid; Receptors, Opioid, mu; Spiperone; Synaptic Transmission; Tomography, Emission-Computed

1985
An improved synthesis of (3-N-[11C]methyl)spiperone.
    International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes, 1986, Volume: 37, Issue:5

    Topics: Carbon Radioisotopes; Chromatography, High Pressure Liquid; Spiperone

1986
Positron emission tomographic study of D2 dopamine receptor binding and CSF biogenic amine metabolites in Rett syndrome.
    American journal of medical genetics. Supplement, 1986, Volume: 1

    Topics: Adult; Binding Sites; Biogenic Amines; Brain; Chromatography, High Pressure Liquid; Female; Humans; Intellectual Disability; Movement Disorders; Receptors, Dopamine; Spiperone; Syndrome; Tomography, Emission-Computed; Tomography, X-Ray Computed

1986
Rett syndrome: positron emission tomography (PET) studies.
    American journal of medical genetics. Supplement, 1986, Volume: 1

    Topics: Adult; Age Factors; Aged; Brain; Deoxyglucose; Female; Fluorodeoxyglucose F18; Glucose; Humans; Intellectual Disability; Male; Middle Aged; Movement Disorders; Receptors, Dopamine; Spiperone; Syndrome; Time Factors; Tomography, Emission-Computed

1986
Parkinson's disease and PET tracer studies.
    Journal of neural transmission. Supplementum, 1988, Volume: 27

    Topics: Animals; Carbon Radioisotopes; Cerebrovascular Circulation; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Energy Metabolism; Fluorine Radioisotopes; Humans; Ligands; Nomifensine; Parkinson Disease; Receptors, Dopamine; Selegiline; Spiperone; Tomography, Emission-Computed

1988
Receptor binding and selectivity of three 11C-labelled dopamine receptor antagonists in the brain of rhesus monkeys studied with positron emission tomography.
    Acta neurologica Scandinavica, 1988, Volume: 77, Issue:4

    Topics: Animals; Brain; Clozapine; Female; Macaca mulatta; Raclopride; Receptors, Dopamine; Salicylamides; Spiperone; Tissue Distribution; Tomography, Emission-Computed

1988
Brain dopaminergic system studied in patients with dystonia using positron emission tomography.
    Advances in neurology, 1988, Volume: 50

    Topics: Adult; Brain; Dopamine; Dystonia; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Spiperone; Tomography, Emission-Computed; Torticollis

1988
PET imaging of cortical S2 serotonin receptors after stroke: lateralized changes and relationship to depression.
    The American journal of psychiatry, 1988, Volume: 145, Issue:8

    Topics: Adult; Aged; Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Disorders; Depressive Disorder; Female; Functional Laterality; Humans; Male; Middle Aged; Parietal Lobe; Receptors, Serotonin; Spiperone; Temporal Lobe; Tomography, Emission-Computed

1988
Characteristics of specific in vivo labeling of neuroleptic binding sites with 3-N-[11C]methylspiperone.
    European journal of nuclear medicine, 1986, Volume: 11, Issue:11

    Topics: Animals; Binding Sites; Brain; Butyrophenones; Carbon Radioisotopes; Cerebellum; Dogs; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Tissue Distribution; Tomography, Emission-Computed

1986
Improved delineation of human dopamine receptors using [18F]-N-methylspiroperidol and PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1986, Volume: 27, Issue:12

    Topics: Adult; Brain; Caudate Nucleus; Fluorine; Frontal Lobe; Half-Life; Humans; Kinetics; Male; Putamen; Radioisotopes; Radioligand Assay; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed

1986
Fluorine-18-N-methylspiroperidol: radiolytic decomposition as a consequence of high specific activity and high dose levels.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1987, Volume: 28, Issue:1

    Topics: Chromatography, High Pressure Liquid; Fluorine; Hydrogen-Ion Concentration; Isotope Labeling; Kinetics; Quality Control; Radiochemistry; Radioisotopes; Solutions; Spiperone; Tomography, Emission-Computed

1987
Positron emission tomography (PET) in the study of dopamine receptors in the primate brain: evaluation of a kinetic model using 11C-N-methyl-spiperone.
    Acta neurologica Scandinavica, 1987, Volume: 75, Issue:3

    Topics: Animals; Brain; Carbon Radioisotopes; Female; Kinetics; Macaca mulatta; Male; Mathematics; Models, Neurological; Radioligand Assay; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed

1987
Tracing of dopamine receptors in hemiparkinsonism with positron emission tomography (PET).
    Journal of the neurological sciences, 1987, Volume: 80, Issue:2-3

    Topics: Adult; Aged; Brain; Female; Functional Laterality; Humans; Male; Middle Aged; Parkinson Disease; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed

1987
No-carrier-added fluorine-18-labeled N-methylspiroperidol: synthesis and biodistribution in mice.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1986, Volume: 27, Issue:2

    Topics: Animals; Brain; Butyrophenones; Female; Fluorine; Isotope Labeling; Mice; Radioisotopes; Radioligand Assay; Radionuclide Imaging; Receptors, Dopamine; Spiperone; Tissue Distribution

1986
A direct comparison of the brain uptake and plasma clearance of N-[11C]methylspiroperidol and [18F]N-methylspiroperidol in baboon using PET.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1986, Volume: 13, Issue:3

    Topics: Animals; Brain; Carbon Radioisotopes; Female; Fluorine; Metabolic Clearance Rate; Papio; Radioisotopes; Radionuclide Imaging; Spiperone

1986
D2 dopamine receptors on bovine chromaffin cell membranes: identification and characterization by [3H]N-methylspiperone binding.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: Animals; Binding, Competitive; Cattle; Chromaffin Granules; Chromaffin System; Kinetics; Rats; Receptors, Dopamine; Spiperone

1987
In vivo binding of 3H-N-methylspiperone to dopamine and serotonin receptors.
    Life sciences, 1987, Mar-09, Volume: 40, Issue:10

    Topics: Animals; Cerebellum; Corpus Striatum; Dose-Response Relationship, Drug; Frontal Lobe; Male; Metabolic Clearance Rate; Mice; Receptors, Dopamine; Receptors, Serotonin; Solubility; Spiperone; Tritium

1987
[18F]-N-Methylspiroperidol: the radioligand of choice for PETT studies of the dopamine receptor in human brain.
    Life sciences, 1985, Apr-08, Volume: 36, Issue:14

    Topics: Animals; Brain; Butyrophenones; Female; Fluorine; Male; Papio; Radioisotopes; Rats; Spiperone; Time Factors; Tomography, Emission-Computed

1985
Dopamine receptor binding of C-11-3-N-methylspiperone in the caudate in schizophrenia and bipolar disorder: a preliminary report.
    Psychopharmacology bulletin, 1985, Volume: 21, Issue:3

    Topics: Adult; Bipolar Disorder; Butyrophenones; Caudate Nucleus; Humans; Receptors, Dopamine; Schizophrenia; Spiperone

1985
Synthesis of N-methyl and N-11C-methyl spiperone by phase transfer catalysis in anhydrous solvent.
    Radioisotopes, 1985, Volume: 34, Issue:9

    Topics: Anhydrides; Brain; Butyrophenones; Carbon Radioisotopes; Catalysis; Chromatography, High Pressure Liquid; Hydrocarbons, Iodinated; Isotope Labeling; Receptors, Dopamine; Solvents; Spiperone

1985
(3-N-[11C]methyl)spiperone, a ligand binding to dopamine receptors: radiochemical synthesis and biodistribution studies in mice.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1984, Volume: 25, Issue:11

    Topics: Animals; Brain; Butyrophenones; Carbon Radioisotopes; Isotope Labeling; Mice; Mice, Inbred ICR; Receptors, Dopamine; Spiperone; Tissue Distribution; Tomography, Emission-Computed

1984
Imaging dopamine receptors in the human brain by positron tomography.
    Science (New York, N.Y.), 1983, Sep-23, Volume: 221, Issue:4617

    Topics: Animals; Brain; Butyrophenones; Caudate Nucleus; Cerebellum; Humans; Papio; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed

1983
Assessment of dopamine receptor densities in the human brain with carbon-11-labeled N-methylspiperone.
    Annals of neurology, 1984, Volume: 15 Suppl

    Topics: Animals; Brain; Butyrophenones; Carbon Radioisotopes; Humans; Male; Middle Aged; Papio; Receptors, Dopamine; Spiperone; Tissue Distribution; Tomography, Emission-Computed

1984
Dopamine receptors in schizophrenia.
    Lancet (London, England), 1995, Nov-11, Volume: 346, Issue:8985

    Topics: Antipsychotic Agents; Corpus Striatum; Dopamine Antagonists; Female; Humans; Male; Putamen; Receptors, Dopamine; Schizophrenia; Spiperone

1995
Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects.
    Life sciences, 1995, Volume: 56, Issue:14

    Topics: Adult; Aging; Brain; Corpus Striatum; Fluorine Radioisotopes; Frontal Lobe; Humans; Male; Middle Aged; Occipital Lobe; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Tomography, Emission-Computed

1995
No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.
    Psychiatry research, 1995, Aug-08, Volume: 61, Issue:2

    Topics: Adult; Carbon Radioisotopes; Cerebellum; Dopamine Agonists; Female; Frontal Lobe; Haloperidol; Humans; Male; Putamen; Radioligand Assay; Receptors, Dopamine D2; Reproducibility of Results; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1995
D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients.
    The American journal of psychiatry, 1995, Volume: 152, Issue:10

    Topics: Adult; Benzazepines; Brain; Clozapine; Female; Humans; Male; Middle Aged; Raclopride; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Treatment Outcome

1995
A rapid and accurate method to realign PET scans utilizing image edge information.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1995, Volume: 36, Issue:4

    Topics: Acetates; Animals; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Dopamine Antagonists; Heart; Humans; Image Processing, Computer-Assisted; Levodopa; Oxygen Radioisotopes; Spiperone; Swine; Tomography, Emission-Computed; Water

1995
Haloperidol blocks the uptake of [18F]N-methylspiroperidol by extrastriatal dopamine receptors in schizophrenic patients.
    Synapse (New York, N.Y.), 1995, Volume: 19, Issue:1

    Topics: Adult; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed

1995
[3H]7-OH-DPAT is capable of labeling dopamine D2 as well as D3 receptors.
    European journal of pharmacology, 1995, Jan-05, Volume: 272, Issue:1

    Topics: Animals; Binding, Competitive; Brain; CHO Cells; Cricetinae; Cricetulus; Dopamine Agonists; Guanine Nucleotides; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes

1995
PET imaging studies of dopamine D2 receptors: comparison of [18F]N-methylspiperone and the benzamide analogues [18F]MABN and [18F]MBP in baboon brain.
    Synapse (New York, N.Y.), 1995, Volume: 19, Issue:3

    Topics: Animals; Benzamides; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Female; Fluorine Radioisotopes; Papio; Piperidines; Receptors, Dopamine D2; Spiperone; Tissue Distribution; Tomography, Emission-Computed

1995
Dopamine D2 receptor binding and cerebral glucose metabolism recover after D-penicillamine-therapy in Wilson's disease.
    Journal of neurology, 1994, Volume: 241, Issue:10

    Topics: Adult; Basal Ganglia; Brain; Deoxyglucose; Dopamine Agents; Fluorine Radioisotopes; Glucose; Hepatolenticular Degeneration; Humans; Magnetic Resonance Imaging; Male; Neurons; Penicillamine; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1994
Ketamine increases the striatal N-[11C]methylspiperone binding in vivo: positron emission tomography study using conscious rhesus monkey.
    Brain research, 1994, Nov-14, Volume: 663, Issue:2

    Topics: Animals; Behavior, Animal; Carbon Radioisotopes; Corpus Striatum; Dopamine; Ketamine; Macaca mulatta; Male; Microdialysis; Radioligand Assay; Spiperone; Tomography, Emission-Computed

1994
Dopamine D2 receptor density estimates in schizophrenia: a positron emission tomography study with 11C-N-methylspiperone.
    Psychiatry research, 1993, Volume: 49, Issue:3

    Topics: Adult; Carbon Radioisotopes; Chronic Disease; Cohort Studies; Corpus Striatum; Dopamine Agents; Female; Humans; Male; Psychiatric Status Rating Scales; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1993
Constitutive expression of the human D2S-dopamine receptor in the unicellular yeast Saccharomyces cerevisiae.
    Biochimica et biophysica acta, 1994, Aug-03, Volume: 1193, Issue:2

    Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cell Membrane; Gene Expression; Molecular Sequence Data; Receptors, Dopamine D2; Saccharomyces cerevisiae; Spiperone

1994
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers.
    Synapse (New York, N.Y.), 1993, Volume: 14, Issue:2

    Topics: Adult; Brain; Cocaine; Deoxyglucose; Dopamine Agents; Fluorodeoxyglucose F18; Frontal Lobe; Glucose; Humans; Male; Receptors, Dopamine D2; Reference Values; Spiperone; Substance-Related Disorders; Tomography, Emission-Computed

1993
Striatal [11C]-N-methyl-spiperone binding in patients with focal dystonia (torticollis) using positron emission tomography.
    Journal of neural transmission. Parkinson's disease and dementia section, 1993, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Aged; Cerebral Cortex; Corpus Striatum; Dopamine Agents; Female; Functional Laterality; Humans; Male; Middle Aged; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed; Torticollis

1993
Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Animals; Antipsychotic Agents; Binding Sites; Clozapine; Corpus Striatum; Dopamine Agents; Dose-Response Relationship, Drug; Kinetics; Male; Mice; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Tritium

1993
Dopamine D2 and serotonin S2 receptors in susceptibility to methamphetamine psychosis detected by positron emission tomography.
    Psychiatry research, 1993, Volume: 50, Issue:4

    Topics: Adult; Cerebral Cortex; Corpus Striatum; Frontal Lobe; Humans; Male; Methamphetamine; Psychoses, Substance-Induced; Radioligand Assay; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Substance-Related Disorders; Tomography, Emission-Computed

1993
Estimation of upper limits on human radiation absorbed doses from carbon-11-labeled compounds.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:12

    Topics: Animals; Benztropine; Carbon Radioisotopes; Cocaine; Deoxyglucose; Dogs; Humans; Mice; Models, Biological; Papio; Putrescine; Radiation Dosage; Selegiline; Spiperone; Tissue Distribution

1993
Comparison of two PET radioligands for imaging extrastriatal dopamine receptors in the human brain.
    Synapse (New York, N.Y.), 1993, Volume: 15, Issue:3

    Topics: Adult; Brain; Carbon Radioisotopes; Fluorine Radioisotopes; Humans; Kinetics; Male; Middle Aged; Organ Specificity; Pituitary Gland; Raclopride; Radioligand Assay; Receptors, Dopamine; Reference Values; Salicylamides; Spiperone; Tomography, Emission-Computed

1993
[Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma].
    Kaku igaku. The Japanese journal of nuclear medicine, 1993, Volume: 30, Issue:6

    Topics: Adenoma; Adult; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Pituitary Neoplasms; Prolactinoma; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1993
The detection of age-related decrease of dopamine D1, D2 and serotonin 5-HT2 receptors in living human brain.
    Progress in neuro-psychopharmacology & biological psychiatry, 1993, Volume: 17, Issue:3

    Topics: Adult; Aged; Aging; Benzazepines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Female; Humans; Male; Middle Aged; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Spiperone; Tomography, Emission-Computed

1993
Synthesis and in vivo evaluation of [18F]-N-(p-nitrobenzyl)spiperone ([18F]PNBS) in rats.
    Nuclear medicine and biology, 1993, Volume: 20, Issue:3

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fluorine Radioisotopes; Isotope Labeling; Ligands; Nitrobenzenes; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spiperone; Tissue Distribution; Tomography, Emission-Computed

1993
Differentiating dopamine D2 ligands by their sensitivities to modification of the cysteine exposed in the binding-site crevice.
    Molecular pharmacology, 1996, Volume: 49, Issue:4

    Topics: Benzamides; Binding Sites; Cell Line; Cysteine; Humans; Mutagenesis, Site-Directed; Receptors, Dopamine D2; Spiperone; Structure-Activity Relationship

1996
Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.
    Biochemistry, 1996, Sep-03, Volume: 35, Issue:35

    Topics: Amino Acid Sequence; Binding Sites; Cell Line; Cysteine; Dopamine Antagonists; Ethyl Methanesulfonate; GTP-Binding Proteins; Humans; Kinetics; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Dopamine D2; Signal Transduction; Spiperone; Sulfhydryl Reagents; Sulpiride

1996
Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol.
    Psychiatry research, 1996, May-31, Volume: 67, Issue:1

    Topics: Adult; Age Factors; Aged; Aging; Cerebellum; Corpus Striatum; Dopamine Agonists; Female; Humans; Ligands; Male; Middle Aged; Nerve Degeneration; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone; Tomography, Emission-Computed

1996
Functional analysis of the human D2 dopamine receptor missense variants.
    The Journal of biological chemistry, 1996, Oct-18, Volume: 271, Issue:42

    Topics: Animals; Binding, Competitive; Cell Line; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine; Dopamine Agonists; Female; Humans; Kinetics; Ovary; Polymorphism, Genetic; Receptors, Dopamine D2; Spiperone

1996
Residues in the fifth membrane-spanning segment of the dopamine D2 receptor exposed in the binding-site crevice.
    Biochemistry, 1995, Dec-19, Volume: 34, Issue:50

    Topics: Amino Acid Sequence; Binding Sites; Cysteine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Resistance; Ethyl Methanesulfonate; Humans; Mesylates; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Receptors, Dopamine D2; Spiperone; Sulpiride; Transfection

1995
Effects of binge pattern cocaine administration on dopamine D1 and D2 receptors in the rat brain: an in vivo study using positron emission tomography.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Dec-01, Volume: 16, Issue:23

    Topics: Animals; Benzazepines; Brain; Cocaine; Dopamine Agonists; Dopamine Antagonists; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1996
Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands.
    European journal of nuclear medicine, 1996, Volume: 23, Issue:2

    Topics: Adult; Brain; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Fentanyl; Humans; Infusion Pumps; Male; Raclopride; Radioligand Assay; Radionuclide Imaging; Receptors, Opioid; Salicylamides; Spiperone

1996
In vivo reconstitution of dopamine D2S receptor-mediated G protein activation in baculovirus-infected insect cells: preferred coupling to Gi1 versus Gi2.
    Biochemistry, 1996, Dec-03, Volume: 35, Issue:48

    Topics: Adenosine Triphosphate; Animals; Apomorphine; Baculoviridae; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Dopamine Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Receptors, Dopamine D2; Spiperone; Spodoptera

1996
Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.
    Journal of neural transmission. General section, 1995, Volume: 100, Issue:2

    Topics: Anesthetics; Animals; Brain; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Female; Isoflurane; Ketamine; Macaca mulatta; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone; Tomography, Emission-Computed

1995
PET measurement of neuroreceptor occupancy by typical and atypical neuroleptics.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1996, Volume: 37, Issue:7

    Topics: Adult; Antipsychotic Agents; Basal Ganglia; Bipolar Disorder; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Clozapine; Dopamine Agonists; Female; Humans; Male; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Spiperone; Tomography, Emission-Computed

1996
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine Agonists; Guinea Pigs; Haloperidol; Humans; Image Processing, Computer-Assisted; Kinetics; Male; Models, Neurological; Nerve Tissue Proteins; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1997
Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Adult; Aged; Aging; Basal Ganglia; Bipolar Disorder; Brain Chemistry; Caudate Nucleus; Chromatography, High Pressure Liquid; Dopamine Agonists; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1997
Antagonist binding characteristics of the Ser311-->Cys variant of human dopamine D2 receptor in vivo and in vitro.
    Biochemical and biophysical research communications, 1997, Mar-06, Volume: 232, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Animals; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Heterozygote; Humans; Male; Middle Aged; Protein Binding; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Serine; Spiperone

1997
D2-like dopamine receptor density in Tourette syndrome measured by PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:8

    Topics: Adult; Brain; Carbon Radioisotopes; Case-Control Studies; Dopamine Agonists; Female; Humans; Male; Neuropsychological Tests; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed; Tourette Syndrome

1997
Time course of 5-HT2A receptor occupancy in the human brain after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1997, Volume: 17, Issue:3

    Topics: Adult; Antipsychotic Agents; Brain; Carbon Radioisotopes; Female; Fluorobenzenes; Humans; Male; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Time Factors; Tomography, Emission-Computed

1997
Amphetamine effects on dopamine release and synthesis rate studied in the Rhesus monkey brain by positron emission tomography.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:4-5

    Topics: Amphetamine; Animals; Brain; Cerebrovascular Circulation; Decarboxylation; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Female; Levodopa; Macaca mulatta; Raclopride; Salicylamides; Spiperone; Tomography, Emission-Computed

1997
Use of positron emission tomography to measure the effects of nalmefene on D1 and D2 dopamine receptors in rat brain.
    Brain research, 1997, Nov-14, Volume: 775, Issue:1-2

    Topics: Animals; Benzazepines; Brain Chemistry; Cerebral Cortex; Dopamine Agonists; Dopamine Antagonists; Male; Naltrexone; Narcotic Antagonists; Neostriatum; Pilot Projects; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1997
A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice.
    Biochemistry, 1998, Jan-27, Volume: 37, Issue:4

    Topics: Amino Acid Sequence; Amino Acids, Cyclic; Binding Sites; Dopamine Agonists; Dopamine Antagonists; Ethyl Methanesulfonate; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Receptors, Dopamine D2; Spiperone; Sulpiride

1998
Sustained withdrawal allows normalization of in vivo [11C]N-methylspiperone dopamine D2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1998, Volume: 19, Issue:2

    Topics: Analysis of Variance; Animals; Benzazepines; Brain; Carbon Radioisotopes; Cocaine; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Spiperone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Tomography, Emission-Computed

1998
Effects of the GABAergic system on in vivo binding of [3H]N-methylspiperone.
    Neuropharmacology, 1998, Volume: 37, Issue:3

    Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Dopamine Agonists; Flunitrazepam; GABA Agonists; Male; Mice; Neostriatum; Neurotransmitter Uptake Inhibitors; Nipecotic Acids; Oximes; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, GABA; Receptors, GABA-A; Spiperone; Tritium

1998
Opposing effects of clomipramine on [125I]RTI-55 and [3H]N-methylspiperone binding in mouse striatum: important role of other factors than endogenous dopamine?
    Synapse (New York, N.Y.), 1998, Volume: 30, Issue:3

    Topics: Animals; Brain; Carrier Proteins; Clomipramine; Cocaine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Organ Specificity; Radioligand Assay; Serotonin; Serotonin Plasma Membrane Transport Proteins; Spiperone; Tritium

1998
Magnetic resonance imaging and 11C-N-methylspiperone/positron emission tomography studies in a patient with the interval form of carbon monoxide poisoning.
    Journal of the neurological sciences, 1998, Sep-18, Volume: 160, Issue:1

    Topics: Basal Ganglia; Bromocriptine; Carbon Monoxide Poisoning; Carbon Radioisotopes; Caudate Nucleus; Cerebral Hemorrhage; Combined Modality Therapy; Convalescence; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Globus Pallidus; Humans; Hyperbaric Oxygenation; Levodopa; Magnetic Resonance Imaging; Male; Middle Aged; Necrosis; Nerve Tissue Proteins; Parkinson Disease, Secondary; Psychomotor Performance; Putamen; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

1998
Changes in apparent in vivo binding of [3H]raclopride and [3H]N-methylspiperone induced by oxotremorine.
    Journal of neural transmission (Vienna, Austria : 1996), 1998, Volume: 105, Issue:10-12

    Topics: Animals; Brain; Male; Mice; Mice, Inbred Strains; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Scopolamine; Spiperone; Tritium

1998
A crystallographic and molecular modeling study of butyrophenones.
    Journal of pharmaceutical sciences, 1998, Volume: 87, Issue:12

    Topics: Butyrophenones; Crystallography; Fluspirilene; Models, Molecular; Molecular Structure; Pimozide; Spiperone

1998
Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: Algorithms; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Kinetics; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Salicylamides; Sodium; Spiperone; Thermodynamics; Zinc

1999
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
    Journal of neurochemistry, 1999, Volume: 72, Issue:5

    Topics: Amphetamines; Binding, Competitive; Cell Line; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Isomerism; Ligands; Models, Biological; Phosphatidylinositols; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone

1999
Enhancement of 3H-N-methylspiperone binding but not 3H-raclopride binding in mouse striatum by MK-801: evidence that factors other than competition by endogenous dopamine are responsible for changes in D2 receptor binding in vivo. Short communication.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:2

    Topics: Animals; Binding Sites; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Kinetics; Mice; Models, Biological; Neostriatum; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone

1999
Comparison of three PET dopamine D2-like receptor ligands, [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone, in rats.
    Annals of nuclear medicine, 1999, Volume: 13, Issue:3

    Topics: Animals; Benzamides; Brain; Cerebellum; Dopamine Agonists; Dopamine Antagonists; Ligands; Male; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D2; Salicylamides; Spiperone; Tissue Distribution; Tomography, Emission-Computed; Visual Cortex

1999
Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000, Volume: 41, Issue:1

    Topics: Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Female; Humans; Male; Middle Aged; Parkinson Disease; Putamen; Raclopride; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed; Up-Regulation

2000
Discrepancies in apparent dopamine D2 receptor occupancy between 3H-raclopride and 3H-N-methylspiperone.
    Journal of neural transmission (Vienna, Austria : 1996), 1999, Volume: 106, Issue:11-12

    Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Male; Mice; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Spiperone; Tritium

1999
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
    European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3

    Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium

2000
Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography.
    Life sciences, 2000, Volume: 66, Issue:25

    Topics: Adult; Carbon Isotopes; Cerebral Cortex; Humans; Receptors, Serotonin; Schizophrenia; Spiperone; Tomography, Emission-Computed

2000
Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release.
    Synapse (New York, N.Y.), 2000, Volume: 38, Issue:1

    Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Female; Haloperidol; Neostriatum; Radioligand Assay; Receptors, Dopamine D2; Spiperone; Swine; Tomography, Emission-Computed

2000
A consideration of the dopamine D2 receptor monomer-dimer equilibrium and the anomalous binding properties of the dopamine D2 receptor ligand, N-methyl spiperone.
    Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:3

    Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dimerization; Dopamine Antagonists; Kinetics; Ligands; Models, Biological; Papio; Raclopride; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed

2001
Effects of endogenous neurotransmitters on the in vivo binding of dopamine and 5-HT radiotracers in mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:5

    Topics: Animals; Binding, Competitive; Dopamine; Dopamine Agonists; Dopamine Antagonists; Male; Mice; Neurotransmitter Agents; Papaverine; Piperazines; Pyridines; Radiopharmaceuticals; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D1; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Spiperone; Tetrahydroisoquinolines

2001
Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone.
    Nuclear medicine and biology, 2002, Volume: 29, Issue:3

    Topics: Animals; Autoradiography; Benzamides; Dopamine Antagonists; Glucose; Magnetic Resonance Imaging; Male; Neostriatum; Neurotoxins; Quinolinic Acid; Raclopride; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, GABA-A; Spiperone; Tomography, Emission-Computed

2002
Hemiparkinsonism associated with a mesencephalic tumor.
    Journal of the neurological sciences, 2002, May-15, Volume: 197, Issue:1-2

    Topics: Brain Stem Neoplasms; Carbon Radioisotopes; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine Agents; Female; Fluorine Radioisotopes; Functional Laterality; Humans; Middle Aged; Parkinsonian Disorders; Putamen; Spiperone; Tomography, Emission-Computed

2002
Effects of rolipram on in vivo dopamine receptor binding.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:9

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzazepines; Binding Sites; Brain; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mice; Neurons; Phosphodiesterase Inhibitors; Raclopride; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Rolipram; Spiperone

2002
MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain.
    Synapse (New York, N.Y.), 2004, Sep-15, Volume: 53, Issue:4

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Corpus Striatum; Dopamine; Down-Regulation; Drug Interactions; Female; N-Methyl-3,4-methylenedioxyamphetamine; Presynaptic Terminals; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Serotonin; Spiperone; Sus scrofa; Tomography, Emission-Computed

2004
A positron emission tomography study on the role of nigral lesions in parkinsonism in patients with amyotrophic lateral sclerosis.
    Archives of neurology, 2006, Volume: 63, Issue:12

    Topics: Aged; Amyotrophic Lateral Sclerosis; Cerebrovascular Circulation; Female; Humans; Levodopa; Male; Middle Aged; Motor Neuron Disease; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Spiperone; Substantia Nigra; Tomography, Emission-Computed, Single-Photon

2006
11C-NMSP/ 18F-FDG microPET to monitor neural stem cell transplantation in a rat model of traumatic brain injury.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:9

    Topics: Animals; Brain Injuries; Carbon Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Gene Expression Regulation; Immunohistochemistry; Neurons; Positron-Emission Tomography; Rats; Receptors, Dopamine D2; Spiperone; Stem Cell Transplantation

2008
Selective alterations of brain dopamine D(2) receptor binding in cirrhotic patients: results of a (11)C-N-methylspiperone PET study.
    Metabolic brain disease, 2008, Volume: 23, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Brain; Brain Chemistry; Female; Humans; Linear Models; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Dopamine D2; Spiperone

2008
Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease.
    Nuclear medicine communications, 2010, Volume: 31, Issue:2

    Topics: Aged; Binding, Competitive; Carbon Radioisotopes; Case-Control Studies; Dopamine; Female; Humans; Linear Models; Male; Middle Aged; Neostriatum; Nortropanes; Parkinson Disease; Positron-Emission Tomography; Raclopride; Reproducibility of Results; Retrospective Studies; Spiperone; Synapses

2010
Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:9

    Topics: Animals; Apomorphine; Binding, Competitive; Cerebellum; Dopamine Agonists; Dopamine beta-Hydroxylase; Female; Kinetics; Male; Mice; Mice, Knockout; Neostriatum; Positron-Emission Tomography; Radioligand Assay; Radiopharmaceuticals; Receptors, Dopamine D2; Spiperone

2010
Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging.
    European journal of nuclear medicine and molecular imaging, 2017, Volume: 44, Issue:6

    Topics: Adult; Brain Mapping; Carbon Radioisotopes; Emotions; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; Music; Spiperone; Tomography, X-Ray Computed; Young Adult

2017