3-n-methylspiperone has been researched along with raclopride in 33 studies
| Studies (3-n-methylspiperone) | Trials (3-n-methylspiperone) | Recent Studies (post-2010) (3-n-methylspiperone) | Studies (raclopride) | Trials (raclopride) | Recent Studies (post-2010) (raclopride) |
|---|---|---|---|---|---|
| 155 | 6 | 7 | 1,802 | 132 | 419 |
| Protein | Taxonomy | 3-n-methylspiperone (IC50) | raclopride (IC50) |
|---|---|---|---|
| D(2) dopamine receptor | Homo sapiens (human) | 0.052 | |
| D(2) dopamine receptor | Mus musculus (house mouse) | 0.032 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.0279 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.09) | 18.7374 |
| 1990's | 21 (63.64) | 18.2507 |
| 2000's | 7 (21.21) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Billings, J; Kung, HF; Kung, MP; Murphy, RA | 1 |
| Guo, YZ; Kasliwal, R; Kung, HF; Kung, MP; Mach, RH; Pan, SG | 1 |
| Benjamin, PS; Schetz, JA; Sibley, DR | 1 |
| Chen, J; Jiang, C; Keck, TM; Levant, B; Newman, AH; Wang, S | 1 |
| Wong, DF | 1 |
| Inoue, O; Itoh, T; Kobayashi, K; Langstrom, B; Tsukada, H | 1 |
| Chen, C; Goldman, S; Matsumura, K; Minkin, E; Scheffel, U; Wagner, HN; Wong, DF; Young, LT | 1 |
| Farde, L; Hall, H; Halldin, C; Kopp, J; Wedel, I | 1 |
| Långström, B | 1 |
| Andreasen, NC; Carson, R; Diksic, M; Evans, A; Farde, L; Gjedde, A; Hakim, A; Lal, S; Nair, N; Sedvall, G | 1 |
| Axelsson, S; Eckernäs, SA; Ekblom, B; Fasth, KJ; Gullberg, P; Hartvig, P; Långström, B; Lindström, L; Lundqvist, H | 1 |
| Farde, L; Halldin, C; Karlsson, P; Nordström, AL; Nyberg, S; Sedvall, G | 1 |
| Farde, L; Halldin, C; Nordström, AL | 1 |
| Fowler, JS; Hitzemann, RJ; MacGregor, RR; Schlyer, DJ; Shea, CE; Volkow, ND; Wang, GJ; Wolf, AP | 1 |
| Fowler, JS; Gatley, SJ; Hitzemann, R; Logan, J; MacGregor, RR; Schlyer, DJ; Volkow, ND; Wang, GJ; Wolf, AP | 1 |
| Dannals, RF; Kao, PF; Kim, S; Lever, JR; Ravert, HT; Wagner, HN | 1 |
| Inoue, O; Kobayashi, K; Långström, B; Onoe, H; Watanabe, Y | 1 |
| Cravchik, A; Gejman, PV; Hietala, J; Någren, K; Pohjalainen, T; Rinne, J; Syvälahti, E | 1 |
| Bjurling, P; Fasth, KJ; Hartvig, P; Långström, B; Tedroff, J; Torstenson, R; Watanabe, Y | 1 |
| Bergström, M; Gefvert, O; Hagberg, G; Långström, B; Lindström, L; Wiesel, FA; Wieselgren, IM | 1 |
| Gee, A; Hosoi, R; Inoue, O; Kobayashi, K | 1 |
| Chu, A; Schetz, JA; Sibley, DR | 1 |
| Gee, A; Inoue, O; Kobayashi, K; Wakahara, S | 1 |
| Eriksson, B; Farde, L; Halldin, C; Nyberg, S; Oxenstierna, G | 1 |
| Endo, K; Hayakawa, N; Ishiwata, K; Oda, K; Ogi, N; Senda, M; Tanaka, A; Toyama, H | 1 |
| Kaasinen, V; Lehikoinen, P; Någren, K; Oikonen, V; Rinne, JO; Ruottinen, HM | 1 |
| Gee, A; Hosoi, R; Inoue, O; Kobayashi, K; Yamaguchi, M | 1 |
| Dewey, SL; Fowler, JS; Gatley, SJ; Logan, J; Volkow, ND | 1 |
| Endo, K; Hayakawa, N; Ishiwata, K; Nagaoka, T; Oda, K; Ogi, N; Senda, M; Tanaka, A; Toyama, H; Umegaki, H | 1 |
| Gee, A; Hosoi, R; Inoue, O; Ishikawa, M; Kobayashi, K; Yamaguchi, M | 1 |
| Cumming, P; Gjedde, A; Jensen, SB; Munk, OL; Olsen, AK; Rosa-Neto, P; Watanabe, H | 1 |
| Iwata, Y; Minabe, Y; Mori, N; Nakamura, K; Okada, H; Ouchi, Y; Sekine, Y; Sugihara, G; Suzuki, K; Takei, N; Tsuchiya, KJ; Yoshikawa, E | 1 |
| Ishibashi, K; Ishii, K; Ishiwata, K; Mizusawa, H; Oda, K | 1 |
2 review(s) available for 3-n-methylspiperone and raclopride
| Article | Year |
|---|---|
Design of molecules labeled with beta+ emitters for use in multitracer investigations using positron emission tomography.
Topics: Beta Particles; Humans; Isotope Labeling; Levodopa; Methionine; Neurotransmitter Agents; Nomifensine; Raclopride; Salicylamides; Spiperone; Tomography, Emission-Computed | 1990 |
Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
Topics: Adult; Corpus Striatum; Haloperidol; Humans; National Institute of Mental Health (U.S.); Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; United States | 1988 |
4 trial(s) available for 3-n-methylspiperone and raclopride
| Article | Year |
|---|---|
High 5-HT2 receptor occupancy in clozapine treated patients demonstrated by PET.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine Agonists; Female; Humans; Male; Middle Aged; Prefrontal Cortex; Psychotic Disorders; Raclopride; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1993 |
N-[11C]methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic.
Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Cerebellum; Dibenzothiazepines; Dopamine; Dose-Response Relationship, Drug; Humans; Male; Putamen; Quetiapine Fumarate; Raclopride; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed | 1998 |
Suggested minimal effective dose of risperidone based on PET-measured D2 and 5-HT2A receptor occupancy in schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Brain; Carbon Radioisotopes; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fluorine Radioisotopes; Humans; Male; Psychiatric Status Rating Scales; Raclopride; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; Treatment Outcome | 1999 |
Perospirone is a new generation antipsychotic: evidence from a positron emission tomography study of serotonin 2 and D2 receptor occupancy in the living human brain.
Topics: Adult; Antipsychotic Agents; Binding, Competitive; Brain; Humans; Indoles; Isoindoles; Male; Positron-Emission Tomography; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Reference Values; Spiperone; Thiazoles | 2006 |
27 other study(ies) available for 3-n-methylspiperone and raclopride
| Article | Year |
|---|---|
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.
Topics: Animals; Benzofurans; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; Iodine Radioisotopes; Isotope Labeling; Male; Molecular Structure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tissue Distribution | 1990 |
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.
Topics: Animals; Benzamides; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Iodine Radioisotopes; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship | 1988 |
Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology.
Topics: Animals; Binding Sites; COS Cells; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Ligands; Membrane Proteins; Mutagenesis, Site-Directed; Protein Conformation; Pyridines; Pyrroles; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship; Transfection | 2000 |
Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D₃ receptor antagonists.
Topics: Animals; Arrestins; beta-Arrestins; Cell Line; Cyclobutanes; Humans; Male; Naphthalenes; Radioligand Assay; Rats, Sprague-Dawley; Receptors, Dopamine D3; Stereoisomerism; Structure-Activity Relationship; Tranylcypromine | 2014 |
PET studies of neuroreceptors in schizophrenia. Commentary on "The current status of PET scanning with respect to schizophrenia".
Topics: Brain; Carbon Radioisotopes; Dopamine Antagonists; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tritium | 1992 |
Difference in in vivo receptor binding between [3H]N-methylspiperone and [3H]raclopride in reserpine-treated mouse brain.
Topics: Animals; Cerebellum; Corpus Striatum; Dopamine Agents; Male; Mice; Raclopride; Receptors, Dopamine; Reserpine; Salicylamides; Spiperone | 1991 |
Effects of endogenous dopamine on kinetics of [3H]N-methylspiperone and [3H]raclopride binding in the rat brain.
Topics: Amphetamine; Animals; Brain; Dopamine; Dopamine Antagonists; Kinetics; Male; Raclopride; Rats; Reserpine; Salicylamides; Spiperone; Tomography, Emission-Computed; Tritium | 1991 |
Comparison of the in vitro receptor binding properties of N-[3H]methylspiperone and [3H]raclopride to rat and human brain membranes.
Topics: Animals; Binding, Competitive; Brain; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Humans; Male; Membranes; Putamen; Raclopride; Rats; Salicylamides; Spiperone; Tritium | 1990 |
Receptor binding and selectivity of three 11C-labelled dopamine receptor antagonists in the brain of rhesus monkeys studied with positron emission tomography.
Topics: Animals; Brain; Clozapine; Female; Macaca mulatta; Raclopride; Receptors, Dopamine; Salicylamides; Spiperone; Tissue Distribution; Tomography, Emission-Computed | 1988 |
D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients.
Topics: Adult; Benzazepines; Brain; Clozapine; Female; Humans; Male; Middle Aged; Raclopride; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Schizophrenia; Spiperone; Tomography, Emission-Computed; Treatment Outcome | 1995 |
Comparison of two PET radioligands for imaging extrastriatal dopamine receptors in the human brain.
Topics: Adult; Brain; Carbon Radioisotopes; Fluorine Radioisotopes; Humans; Kinetics; Male; Middle Aged; Organ Specificity; Pituitary Gland; Raclopride; Radioligand Assay; Receptors, Dopamine; Reference Values; Salicylamides; Spiperone; Tomography, Emission-Computed | 1993 |
Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol.
Topics: Adult; Age Factors; Aged; Aging; Cerebellum; Corpus Striatum; Dopamine Agonists; Female; Humans; Ligands; Male; Middle Aged; Nerve Degeneration; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone; Tomography, Emission-Computed | 1996 |
Assessing neuroreceptor occupancy by continuous infusion of carbon-11 labeled radioligands.
Topics: Adult; Brain; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Fentanyl; Humans; Infusion Pumps; Male; Raclopride; Radioligand Assay; Radionuclide Imaging; Receptors, Opioid; Salicylamides; Spiperone | 1996 |
Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.
Topics: Anesthetics; Animals; Brain; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Female; Isoflurane; Ketamine; Macaca mulatta; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone; Tomography, Emission-Computed | 1995 |
Antagonist binding characteristics of the Ser311-->Cys variant of human dopamine D2 receptor in vivo and in vitro.
Topics: Adult; Aged; Aged, 80 and over; Animals; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Heterozygote; Humans; Male; Middle Aged; Protein Binding; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Serine; Spiperone | 1997 |
Amphetamine effects on dopamine release and synthesis rate studied in the Rhesus monkey brain by positron emission tomography.
Topics: Amphetamine; Animals; Brain; Cerebrovascular Circulation; Decarboxylation; Dopamine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Female; Levodopa; Macaca mulatta; Raclopride; Salicylamides; Spiperone; Tomography, Emission-Computed | 1997 |
Changes in apparent in vivo binding of [3H]raclopride and [3H]N-methylspiperone induced by oxotremorine.
Topics: Animals; Brain; Male; Mice; Mice, Inbred Strains; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Scopolamine; Spiperone; Tritium | 1998 |
Zinc modulates antagonist interactions with D2-like dopamine receptors through distinct molecular mechanisms.
Topics: Algorithms; Animals; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Kinetics; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Salicylamides; Sodium; Spiperone; Thermodynamics; Zinc | 1999 |
Enhancement of 3H-N-methylspiperone binding but not 3H-raclopride binding in mouse striatum by MK-801: evidence that factors other than competition by endogenous dopamine are responsible for changes in D2 receptor binding in vivo. Short communication.
Topics: Animals; Binding Sites; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Kinetics; Mice; Models, Biological; Neostriatum; Raclopride; Receptors, Dopamine D2; Salicylamides; Spiperone | 1999 |
Comparison of three PET dopamine D2-like receptor ligands, [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone, in rats.
Topics: Animals; Benzamides; Brain; Cerebellum; Dopamine Agonists; Dopamine Antagonists; Ligands; Male; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D2; Salicylamides; Spiperone; Tissue Distribution; Tomography, Emission-Computed; Visual Cortex | 1999 |
Upregulation of putaminal dopamine D2 receptors in early Parkinson's disease: a comparative PET study with [11C] raclopride and [11C]N-methylspiperone.
Topics: Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Female; Humans; Male; Middle Aged; Parkinson Disease; Putamen; Raclopride; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed; Up-Regulation | 2000 |
Discrepancies in apparent dopamine D2 receptor occupancy between 3H-raclopride and 3H-N-methylspiperone.
Topics: Animals; Binding Sites; Binding, Competitive; Brain Chemistry; Male; Mice; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Spiperone; Tritium | 1999 |
A consideration of the dopamine D2 receptor monomer-dimer equilibrium and the anomalous binding properties of the dopamine D2 receptor ligand, N-methyl spiperone.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dimerization; Dopamine Antagonists; Kinetics; Ligands; Models, Biological; Papio; Raclopride; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed | 2001 |
Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone.
Topics: Animals; Autoradiography; Benzamides; Dopamine Antagonists; Glucose; Magnetic Resonance Imaging; Male; Neostriatum; Neurotoxins; Quinolinic Acid; Raclopride; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, GABA-A; Spiperone; Tomography, Emission-Computed | 2002 |
Effects of rolipram on in vivo dopamine receptor binding.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzazepines; Binding Sites; Brain; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Mice; Neurons; Phosphodiesterase Inhibitors; Raclopride; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Rolipram; Spiperone | 2002 |
MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Corpus Striatum; Dopamine; Down-Regulation; Drug Interactions; Female; N-Methyl-3,4-methylenedioxyamphetamine; Presynaptic Terminals; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Serotonin; Spiperone; Sus scrofa; Tomography, Emission-Computed | 2004 |
Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease.
Topics: Aged; Binding, Competitive; Carbon Radioisotopes; Case-Control Studies; Dopamine; Female; Humans; Linear Models; Male; Middle Aged; Neostriatum; Nortropanes; Parkinson Disease; Positron-Emission Tomography; Raclopride; Reproducibility of Results; Retrospective Studies; Spiperone; Synapses | 2010 |