Page last updated: 2024-09-03

3-n-methylspiperone and haloperidol

3-n-methylspiperone has been researched along with haloperidol in 14 studies

Compound Research Comparison

Studies
(3-n-methylspiperone)
Trials
(3-n-methylspiperone)
Recent Studies (post-2010)
(3-n-methylspiperone)
Studies
(haloperidol)
Trials
(haloperidol)
Recent Studies (post-2010) (haloperidol)
1556720,3301,7533,294

Protein Interaction Comparison

ProteinTaxonomy3-n-methylspiperone (IC50)haloperidol (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)2.3
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)1.7
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.6765
Potassium channel subfamily K member 2Homo sapiens (human)5.5
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.836
ATP-dependent translocase ABCB1Homo sapiens (human)5.3
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.054
Cytochrome P450 3A4Homo sapiens (human)0.055
5-hydroxytryptamine receptor 1AHomo sapiens (human)1.5
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.1754
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.89
Alpha-2A adrenergic receptorHomo sapiens (human)4.973
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)2.3
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M1Homo sapiens (human)5.5
Cytochrome P450 2C9 Homo sapiens (human)4.69
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)7
D(2) dopamine receptorHomo sapiens (human)0.0897
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.1467
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0852
Alpha-2B adrenergic receptorHomo sapiens (human)1.354
Alpha-2C adrenergic receptorHomo sapiens (human)1.845
DRattus norvegicus (Norway rat)0.1103
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.3045
D(2) dopamine receptorBos taurus (cattle)0.1332
D(1A) dopamine receptorHomo sapiens (human)0.0575
D(4) dopamine receptorHomo sapiens (human)0.0978
D(1B) dopamine receptorHomo sapiens (human)0.005
Adenylate cyclase type 3Rattus norvegicus (Norway rat)2.3
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0852
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.836
Histamine H2 receptorHomo sapiens (human)1.166
Alpha-1D adrenergic receptorHomo sapiens (human)0.084
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0067
Adenylate cyclase type 2Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 4Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.1815
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.347
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.018
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.1754
Sodium-dependent serotonin transporterHomo sapiens (human)3.386
Histamine H1 receptorHomo sapiens (human)2.781
Mu-type opioid receptorHomo sapiens (human)2.443
D(3) dopamine receptorHomo sapiens (human)0.0065
Sodium channel protein type 1 subunit alphaHomo sapiens (human)7
Sodium channel protein type 4 subunit alphaHomo sapiens (human)7
Adenylate cyclase type 8Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.05
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0852
Cytochrome P450 2J2Homo sapiens (human)4.69
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0129
N-acetyltransferase EisMycobacterium tuberculosis H37Rv0.39
Sodium channel protein type 7 subunit alphaHomo sapiens (human)7
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.5
Adenylate cyclase type 6Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 5Rattus norvegicus (Norway rat)1.425
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2634
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.5
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.5
Sodium channel protein type 5 subunit alphaHomo sapiens (human)7
Sodium channel protein type 9 subunit alphaHomo sapiens (human)7
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)2.3
DBos taurus (cattle)0.2509
Sodium channel protein type 2 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.07
Sodium channel protein type 3 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)0.0013
Sodium channel protein type 11 subunit alphaHomo sapiens (human)7
Sodium channel protein type 8 subunit alphaHomo sapiens (human)7
Sodium channel protein type 10 subunit alphaHomo sapiens (human)7

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19905 (35.71)18.7374
1990's7 (50.00)18.2507
2000's2 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Meltzer, HY; Stockmeier, CA1
Bendriem, B; Dewey, SL; Fowler, JS; Hitzemann, R; Logan, J; Raulli, R; Schlyer, DJ; Shiue, CY; Volkow, ND; Wolf, AP1
Coenen, HH; Hamacher, K; Heiss, WD; Herholz, K; Huber, M; Karbe, H; Lövenich, A; Stöcklin, G; Wienhard, K1
Barouche, F; Brodie, JD; Cooper, TB; Fowler, JS; Rotrosen, J; Shiue, CY; Wolf, AP; Wolkin, A1
Broussolle, EP; Dannals, RF; Gjedde, A; Kuhar, MJ; Links, JM; Malat, J; O'Tuama, LA; Pearlson, GD; Ravert, HT; Snyder, SH; Tamminga, CA; Toung, JK; Tune, LE; Wagner, HN; Williams, JA; Wilson, AA; Wong, DF1
Dannals, RF; Douglass, KH; Gjedde, A; Kuhar, MJ; Links, JM; Wagner, HN; Wong, DF1
Arnett, CD; Barouche, F; Brodie, JD; Fowler, JS; MacGregor, RR; Russell, JA; Shiue, CY; Smith, M; Wolf, AP; Wolkin, A1
Andreasen, NC; Carson, R; Diksic, M; Evans, A; Farde, L; Gjedde, A; Hakim, A; Lal, S; Nair, N; Sedvall, G1
Eriksson, L; Farde, L; Halldin, C; Nordström, AL1
Brodie, JD; Fowler, JS; Schlyer, DJ; Smith, MR; Volkow, ND; Wang, GJ; Warner, D; Wolf, AP; Yousef, KA1
Gjedde, A; Meltzer, CC; Wilson, PD; Wong, DF; Young, D1
Conley, RR; Tamminga, CA1
Armogida, M; Chiacchio, S; Colzi, A; Corsini, GU; DeMontis, MG; Maggio, R; Scarselli, M1
Bender, D; Cumming, P; Danielsen, E; Gjedde, A; Hansen, SB; Ishizu, K; Smith, DF; Wong, DF1

Reviews

2 review(s) available for 3-n-methylspiperone and haloperidol

ArticleYear
Workshop on schizophrenia, PET, and dopamine D2 receptors in the human neostriatum.
    Schizophrenia bulletin, 1988, Volume: 14, Issue:3

    Topics: Adult; Corpus Striatum; Haloperidol; Humans; National Institute of Mental Health (U.S.); Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed; United States

1988
The application of neuroimaging techniques to drug development.
    The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 10

    Topics: Antipsychotic Agents; Brain; Brain Chemistry; Carbon Radioisotopes; Cerebrovascular Circulation; Deoxyglucose; Diagnostic Imaging; Drug Industry; Drugs, Investigational; Fluorodeoxyglucose F18; Haloperidol; Humans; Ketamine; Magnetic Resonance Imaging; Mental Disorders; Neuropharmacology; Receptors, Dopamine; Spiperone; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

1997

Other Studies

12 other study(ies) available for 3-n-methylspiperone and haloperidol

ArticleYear
In vivo occupancy of dopamine receptors by antipsychotic drugs.
    Archives of general psychiatry, 1992, Volume: 49, Issue:7

    Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Humans; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone

1992
Regional distribution and kinetics of haloperidol binding in human brain: a PET study with [18F]haloperidol.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:1

    Topics: Adult; Animals; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Male; Mice; Schizophrenia; Spiperone; Tomography, Emission-Computed

1992
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
    Journal of neural transmission. General section, 1991, Volume: 86, Issue:3

    Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tomography, X-Ray Computed

1991
Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia.
    The American journal of psychiatry, 1989, Volume: 146, Issue:7

    Topics: Adolescent; Adult; Cerebellum; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Fluorine Radioisotopes; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed

1989
Positron emission tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics.
    Science (New York, N.Y.), 1986, Dec-19, Volume: 234, Issue:4783

    Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Haloperidol; Humans; Kinetics; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1986
Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1986, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Brain; Caudate Nucleus; Haloperidol; Humans; Kinetics; Ligands; Male; Middle Aged; Models, Biological; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Sensory Receptor Cells; Spiperone; Tomography, Emission-Computed

1986
Serial [18F]N-methylspiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients.
    Biological psychiatry, 1988, Apr-01, Volume: 23, Issue:7

    Topics: Adult; Binding, Competitive; Chlorpromazine; Corpus Striatum; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1988
No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.
    Psychiatry research, 1995, Aug-08, Volume: 61, Issue:2

    Topics: Adult; Carbon Radioisotopes; Cerebellum; Dopamine Agonists; Female; Frontal Lobe; Haloperidol; Humans; Male; Putamen; Radioligand Assay; Receptors, Dopamine D2; Reproducibility of Results; Schizophrenia; Schizophrenic Psychology; Spiperone; Tomography, Emission-Computed

1995
Haloperidol blocks the uptake of [18F]N-methylspiroperidol by extrastriatal dopamine receptors in schizophrenic patients.
    Synapse (New York, N.Y.), 1995, Volume: 19, Issue:1

    Topics: Adult; Brain; Fluorine Radioisotopes; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia; Spiperone; Tomography, Emission-Computed

1995
Quantification of neuroreceptors in the living human brain: III. D2-like dopamine receptors: theory, validation, and changes during normal aging.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:3

    Topics: Aging; Algorithms; Animals; Brain; Brain Chemistry; Computer Simulation; Corpus Striatum; Dopamine Agonists; Guinea Pigs; Haloperidol; Humans; Image Processing, Computer-Assisted; Kinetics; Male; Models, Neurological; Nerve Tissue Proteins; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed

1997
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
    European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3

    Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium

2000
Positron emission tomography of radioligand binding in porcine striatum in vivo: haloperidol inhibition linked to endogenous ligand release.
    Synapse (New York, N.Y.), 2000, Volume: 38, Issue:1

    Topics: Animals; Binding, Competitive; Carbon Radioisotopes; Female; Haloperidol; Neostriatum; Radioligand Assay; Receptors, Dopamine D2; Spiperone; Swine; Tomography, Emission-Computed

2000