Page last updated: 2024-09-03

3-n-methylspiperone and 4-iodo-2,5-dimethoxyphenylisopropylamine

3-n-methylspiperone has been researched along with 4-iodo-2,5-dimethoxyphenylisopropylamine in 2 studies

Compound Research Comparison

Studies (3-n-methylspiperone)	Trials (3-n-methylspiperone)	Recent Studies (post-2010) (3-n-methylspiperone)	Studies (4-iodo-2,5-dimethoxyphenylisopropylamine)	Trials (4-iodo-2,5-dimethoxyphenylisopropylamine)	Recent Studies (post-2010) (4-iodo-2,5-dimethoxyphenylisopropylamine)
155	6	7	843	1	127

Protein Interaction Comparison

Protein	Taxonomy	3-n-methylspiperone (IC50)	4-iodo-2,5-dimethoxyphenylisopropylamine (IC50)
5-hydroxytryptamine receptor 2B	Homo sapiens (human)		0.0032

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kristiansen, K; Kroeze, WK; Roth, BL; Shapiro, DA	1
Conklin, DS; Fitzgerald, LW; Hartig, PR; Iyer, G; Kostich, WA; Krause, CM; Largent, BL; Marshall, AP; Patterson, JP; Tran, DP	1

Other Studies

2 other study(ies) available for 3-n-methylspiperone and 4-iodo-2,5-dimethoxyphenylisopropylamine

Article	Year
Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. Molecular pharmacology, 2000, Volume: 58, Issue:5 Topics: Amino Acid Substitution; Animals; Binding, Competitive; Conserved Sequence; COS Cells; DOM 2,5-Dimethoxy-4-Methylamphetamine; Hydrolysis; Membrane Proteins; Models, Molecular; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Folding; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Signal Transduction; Tryptamines	2000
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. Journal of neurochemistry, 1999, Volume: 72, Issue:5 Topics: Amphetamines; Binding, Competitive; Cell Line; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Isomerism; Ligands; Models, Biological; Phosphatidylinositols; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone	1999

Article

Year

Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5.

Molecular pharmacology, 2000, Volume: 58, Issue:5

Topics: Amino Acid Substitution; Animals; Binding, Competitive; Conserved Sequence; COS Cells; DOM 2,5-Dimethoxy-4-Methylamphetamine; Hydrolysis; Membrane Proteins; Models, Molecular; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Folding; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Signal Transduction; Tryptamines

2000

High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.

Journal of neurochemistry, 1999, Volume: 72, Issue:5

Topics: Amphetamines; Binding, Competitive; Cell Line; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hydrolysis; Isomerism; Ligands; Models, Biological; Phosphatidylinositols; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone

1999