3-n-butylphthalide has been researched along with edaravone in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 11 (57.89) | 2.80 |
| Authors | Studies |
|---|---|
| Ji, H; Lai, Y; Li, T; Ling, J; Liu, J; Peng, S; Tian, J; Wang, X; Wu, J; Zhang, Y | 1 |
| Hua, K; Huang, Z; Ji, H; Sheng, X; Wang, X; Xu, J; Yang, C; Zhang, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Chen, N; Chu, S; Li, C; Li, Y; Liu, D; Ma, J; Ren, Q; Song, X; Zang, Y; Zhang, D | 1 |
| Cui, E; Du, L; Du, S; Jiang, X; Li, J; Ma, X; Qian, S; Wang, H | 1 |
| Kong, X; Li, Q; Liu, L; Liu, X; Long, X; Shi, B; Wang, T; Xiong, N | 1 |
| Hua, K; Huang, ZJ; Ji, H; Li, TT; Sheng, X; Wang, LN; Zhang, YH | 1 |
| Lan, Z; Lei, M; Li, J; Liang, Z; Xu, W; Xu, X; Zhang, X; Zhao, C | 1 |
| Jiang, M; Lu, S; Lyu, Y; Nie, T; Qian, Y; Tang, B | 1 |
| Guo, Y; Li, X; Miao, L; Tian, H; Wang, X; Yuan, R | 1 |
| Guo, Y; Li, X; Lin, X; Liu, Y; Miao, L; Tian, H; Wang, X; Yuan, R | 1 |
| Chang, H; Li, H; Wang, D; Yin, A; Yin, J | 1 |
| Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q | 1 |
| Li, K; Lu, X; Yao, S; Zhang, Q | 1 |
| Huang, Z; Ji, D; Jia, J; Jiao, W; Wang, X; Wu, J; Zhang, Y | 1 |
| Shen, QQ; Tong, XW; Wang, W; Wu, H | 1 |
| Hong, Z; Li, S; Li, Y; Liu, Y; Wang, J; Xie, S | 1 |
| Cai, C; Cui, Y; Deng, L; He, B; Wang, L; Wang, X; Yang, Y; Zhang, H; Zhou, W; Zhu, B | 1 |
| Wang, X; Yang, D; Zhang, J; Zhang, M | 1 |
1 review(s) available for 3-n-butylphthalide and edaravone
| Article | Year |
|---|---|
Clinical Efficacy and Short-Term Prognosis of Butylphthalide and Sodium Chloride Injection Compared to Edaravone in the Treatment of Patients with Acute Stroke.
Topics: Antipyrine; Edaravone; Humans; Sodium Chloride; Stroke; Treatment Outcome | 2023 |
2 trial(s) available for 3-n-butylphthalide and edaravone
| Article | Year |
|---|---|
Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Brain Ischemia; Drug Therapy, Combination; Edaravone; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Kallikreins; Treatment Outcome; Young Adult | 2019 |
The effect of edaravone combined with DL-3-N-butylphthalide on the levels of tumor necrosis factor-alpha, interleukin-10, neuron-specific enolase and effect in patients with acute cerebral infarction.
Topics: Acute Disease; Brain Ischemia; Cerebral Infarction; Edaravone; Humans; Interleukin-10; Phosphopyruvate Hydratase; Quality of Life; Stroke; Tumor Necrosis Factor-alpha | 2022 |
16 other study(ies) available for 3-n-butylphthalide and edaravone
| Article | Year |
|---|---|
Discovery of a potential anti-ischemic stroke agent: 3-pentylbenzo[c]thiophen-1(3H)-one.
Topics: Animals; Antioxidants; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Fibrinolytic Agents; Free Radical Scavengers; Male; Neuroprotective Agents; PC12 Cells; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stereoisomerism; Stroke; Structure-Activity Relationship; Thiophenes | 2012 |
Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents.
Topics: Animals; Antipyrine; Benzofurans; Cell Line; Drug Design; Edaravone; Free Radical Scavengers; Humans; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Stroke | 2015 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Ischemia; Carbazoles; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Molecular Structure; Neurons; Neuroprotective Agents; PC12 Cells; Pyrans; Rats; Rats, Sprague-Dawley; Stroke; Structure-Activity Relationship | 2018 |
Design and synthesis of novel indole and indazole-piperazine pyrimidine derivatives with anti-inflammatory and neuroprotective activities for ischemic stroke treatment.
Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cyclooxygenase 2; Disease Models, Animal; Indazoles; Indoles; Ischemic Stroke; Lipopolysaccharides; Mice; Microglia; Neuroprotection; Neuroprotective Agents; Piperazine; Pyrimidines; Rats; Stroke; Tumor Necrosis Factor-alpha | 2022 |
Combined edaravone and D1-3-n-butylphthalide antioxidant therapy for paraquat poisoning.
Topics: Adult; Antioxidants; Antipyrine; Benzofurans; Drug Therapy, Combination; Edaravone; Emergency Service, Hospital; Humans; Male; Paraquat | 2014 |
The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Benzofurans; Brain; Edaravone; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-kappa B; Rats, Sprague-Dawley; Signal Transduction; Water | 2015 |
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Carrageenan; Cell Line; Disease Models, Animal; Edaravone; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Isoindoles; Male; Mice; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Thrombosis; Tissue Distribution | 2015 |
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Line; Cell Line, Tumor; Drug Design; Edaravone; Glucose; Humans; Hydrogen Peroxide; Hypoxia; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Topics: Animals; Apoptosis; Benzofurans; DNA Damage; Edaravone; Epithelial Cells; Intestine, Small; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Radiation-Protective Agents; Whole-Body Irradiation | 2021 |
Fuzzy
Topics: Algorithms; Benzofurans; Biomarkers; Cerebral Infarction; Drug Therapy, Combination; Edaravone; Endothelium, Vascular; Female; Follow-Up Studies; Fuzzy Logic; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuroprotective Agents; Prognosis | 2021 |
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents | 2021 |
Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke.
Topics: Benzofurans; Edaravone; Humans; Interleukin-6; Ischemic Stroke; Quality of Life; Sodium Chloride; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
Topics: Animals; Benzofurans; Edaravone; Ischemic Stroke; Neuroprotective Agents; Rats; Stroke | 2022 |
Efficacy of Butylphthalide in Combination with Edaravone in the Treatment of Acute Ischemic Stroke and the Effect on Serum Inflammatory Factors.
Topics: Benzofurans; Edaravone; Humans; Inflammation; Interleukin-6; Ischemic Stroke; Stroke | 2023 |
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats.
Topics: Animals; Brain Ischemia; Edaravone; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Kelch-Like ECH-Associated Protein 1; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Rats; Stroke | 2023 |