3-n-butylphthalide has been researched along with benzofurans in 296 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.35) | 18.7374 |
| 1990's | 21 (7.09) | 18.2507 |
| 2000's | 26 (8.78) | 29.6817 |
| 2010's | 163 (55.07) | 24.3611 |
| 2020's | 82 (27.70) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Gao, NN; Li, LL; Wang, WN; Wang, ZY; Yu, SR | 2 |
| You, SQ; Yu, SR | 1 |
| Feng, YP; Hu, D; Zhang, LY | 1 |
| Feng, YP; Liu, XG | 1 |
| Feng, YP; Hu, D; Huang, XX | 1 |
| Feng, YP; Zhang, LY | 1 |
| Tan, BK; Tsi, D | 1 |
| Feng, YP; Hu, D; Huang, XX; Qu, ZW; Zhang, JT | 1 |
| Peng, SH; Zhou, TH | 1 |
| Chong, ZZ; Feng, YP | 3 |
| Feng, YP; Yan, CH; Zhang, JT | 2 |
| Chong, Z; Feng, Y | 3 |
| Feng, YP; Xu, HL | 3 |
| Deng, W; Feng, Y | 1 |
| Dong, GX; Feng, YP | 2 |
| Feng, YP; Wang, CH; Wu, YL | 1 |
| Feng, Y; Yan, C | 3 |
| Feng, Y; Xiong, J | 1 |
| Chang, Q; Wang, XL | 1 |
| Feng, Y; Peng, Y; Wang, X; Zeng, X | 1 |
| Li, XY; Liu, J; Zhu, XZ | 1 |
| Li, P; Li, RY; Li, SL; Qi, LW; Sheng, LH; Zhang, LY | 1 |
| Li, J; Wang, L; Wang, XL; Zhang, Y | 1 |
| Chen, G; Feng, Y; Peng, Y; Wang, L; Wang, X; Xu, S | 1 |
| Huang, RX; Li, CX; Liao, SJ; Lin, JW; Liu, CL; Shi, XG; Xie, LC; Zeng, JS | 1 |
| He, L; Kong, SY; Li, QF; Yang, J | 1 |
| Chen, G; Feng, Y; Lemere, CA; Peng, Y; Wang, L; Wang, X; Xing, C | 1 |
| Deji, QZ; He, L; Kong, SY; Li, QF; Zhou, D | 1 |
| Chen, D; Chen, F; He, Z; Liu, X; Niu, Z; Sun, J; Wang, Y | 1 |
| Luo, Y; Wu, LR | 1 |
| He, L; Sun, J; Sun, Z; Xu, Y; Zheng, C | 1 |
| Feng, N; Li, J; Liu, B; Ma, S; Wang, L; Wang, X; Xu, S | 1 |
| Gao, B; He, L; Li, C | 1 |
| Huang, RX; Liao, SJ; Lin, JW; Liu, CL; Pei, Z; Zeng, JS | 1 |
| Huang, R; Li, L; Pei, Z; Tao, Y; Wang, Y; Wei, H; Zhang, B; Zhao, J | 1 |
| Cao, WY; Deji, QZ; He, L; Li, QF; Zhou, D | 1 |
| Chen, K; Hou, DR; Tian, Y; Wan, S; Zhou, J | 2 |
| Chen, G; Feng, Y; Lemere, CA; Liu, B; Peng, Y; Wang, L; Wang, X; Xing, C; Xu, S | 1 |
| Duan, W; Liu, L; Luo, G; Wang, W; Zhang, H; Zhang, S | 1 |
| Cha, XX; Chang, JB; Gao, Y; Qiao, HL; Reiner, J; Shen, JX; Wang, W | 1 |
| Chen, K; Hou, D; Tian, Y; Wan, S; Xue, L | 1 |
| Chang, JB; Li, YF; Liu, Y; Shen, JX; Wang, Q; Wang, W; Xie, JX | 1 |
| Chen, J; Chen, YZ; Huang, JZ; Liu, CF; Su, M; Yang, YP; Zheng, HF | 1 |
| Jia, W; Sun, X; Zhang, T | 1 |
| Feng, Y; Hon, S; Lemere, CA; Nylander, AN; Peng, Y; Sun, J; Wang, X; Xia, W | 1 |
| Chang, JB; Gao, Y; Qiao, HL; Wang, W; Zhang, HW | 1 |
| Li, J; Li, Y; Ogle, M; Song, M; Wei, L; Yu, SP; Zhou, X | 1 |
| Hou, DR; Sun, JJ; Tang, JC; Xue, L; Zhou, J | 1 |
| Feng, N; Hu, Y; Peng, Y; Wang, L; Wang, X; Xu, S | 1 |
| Feng, N; Hu, Y; Peng, Y; Wang, L; Wang, X | 1 |
| Gao, B; He, L; Li, C; Qiu, B | 1 |
| Cui, YH; Guo, W; Wei, YL; Zhang, CD | 1 |
| Chen, X; Du, S; Lu, Y; Xu, B; Yao, Z | 1 |
| Cao, DX; Ji, XC; Shi, QQ; Wang, XL; Zhao, WH | 1 |
| Cao, X; Chen, C; Hou, L; Huang, J; Jia, M; Liang, Z; Lin, Z; Sun, S; Wang, T; Xiong, N; Yang, H; Zhang, Y; Zhang, Z; Zhao, Y | 1 |
| Fu, J; Jia, W; Li, Q; Liu, K; Liu, X; Sun, X; Yan, W; Zhang, T | 1 |
| Fu, R; Lai, Y; Li, Y; Peng, S; Wang, X; Yu, W; Zhang, Y | 1 |
| Ji, H; Lai, Y; Li, Y; Min, Z; Peng, S; Wang, X; Zhang, C; Zhang, Y; Zhao, Q | 1 |
| Oguro, D; Watanabe, H | 1 |
| Ji, TF; Su, YL; Wang, AG; Wang, J; Yang, JB | 1 |
| Cui, L; Feng, X; Liu, M; Peng, Y | 1 |
| Chen, L; Ji, H; Wang, X; Zhang, C; Zhang, Y; Zhao, Q | 1 |
| Feng, N; Hu, Y; Li, J; Li, P; Lu, L; Peng, Y; Wang, L; Wang, X; Xu, S; Yang, H | 1 |
| Chan, WM; Huang, Y; Lü, L; Wai, MS; Yew, DT; Zhang, L | 1 |
| Chang, FJ; Huang, RX; Lee, SM; Li, L; Li, W; Li, ZX; Liu, ZY; Lu, XL; Luo, D; Ou, JS; Pei, Z; Wang, GL; Wen, L; Yao, XL; Zeng, JS; Zhang, ZJ | 1 |
| Li, N; Wang, Y; Xu, J; Xu, L; Yang, H; Yang, Z | 1 |
| Chen, R; Huang, J; Liu, K; Shen, L; Sun, X; Yang, J; Zhang, T | 1 |
| Du, AL; Hiao, W; Jiang, HB; Li, S; Li, WQ; Zhang, RL | 1 |
| Cao, J; Ding, X; Feng, M; Huang, S; Ke, X; Lu, X; Sun, B; Tian, X; Zhang, Y | 1 |
| Chan, WM; Dong, J; Huang, Y; Qi, W; Wai, MS; Wang, C; Wang, YX; Yew, DT; Yu, WH; Zhang, L; Zhao, F | 1 |
| Cui, LY; Feng, XH; Liu, MS; Peng, Y; Yuan, W | 1 |
| Chen, F; Huang, Y; Li, J; Li, Y; Wei, W; Zhang, W; Zhu, G | 1 |
| Kapoor, S | 1 |
| Chen, X; Deng, P; Diao, X; Li, X; Xie, C; Zhang, Y; Zhong, D | 1 |
| Feng, N; Li, P; Peng, Y; Wang, L; Wang, W; Wang, X; Yuan, H; Zhang, M | 1 |
| Chen, X; Diao, X; Fan, Y; Jin, J; Ma, Z; Wang, H; Zhang, Y; Zhong, D | 1 |
| Huang, Z; Ji, H; Lai, Y; Li, T; Tian, J; Wan, X; Wang, L; Wang, X; Xu, J; Zhang, Y | 1 |
| Imenshahidi, M; Moghadam, MH; Mohajeri, SA | 1 |
| Chen, X; Ji, H; Li, N; Li, T; Lu, Y; Qiu, Z; Wang, X; Zhang, Y; Zhao, D | 1 |
| Kong, X; Li, Q; Liu, L; Liu, X; Long, X; Shi, B; Wang, T; Xiong, N | 1 |
| Huang, JK; Sun, XJ; Wang, HM; Zhang, T | 1 |
| Cui, LY; Peng, B | 1 |
| Cui, LY; Gao, S; He, J; Ma, XQ; Ni, J; Peng, B; Wang, JM; Zhou, LX; Zhu, YC | 1 |
| Chen, X; Diao, X; Lei, P; Ma, Z; Zhang, Y; Zhong, D | 1 |
| Ai, JW; Dong, XY; Feng, ZY; Huang, HY; Li, Y; Lin, Y; Pan, YM; Wang, BX; Wang, CY; Wang, YG; Yao, LL | 1 |
| Huang, J; Li, Q; Sun, X; Wang, H; Zhang, T | 1 |
| Gao, P; Hu, J; Li, B; Wen, Q; Wu, Y | 1 |
| Chen, X; Diao, X; Guo, Z; Pang, X; Xie, C; Zhong, D | 1 |
| Chen, H; Ke, ZJ; Sun, XJ; Wang, F | 1 |
| Huang, Z; Ji, H; Li, T; Sheng, X; Wang, L; Wang, X; Xu, J; Yin, J; Zhang, M; Zhang, Y | 1 |
| Chai, KQ; Huo, XL; Jin, L; Min, JJ; Qin, YQ; Wang, XT; Wu, B; Xiang, LY | 1 |
| Li, J; Wang, M; Wang, R; Zhang, L; Zhang, S | 1 |
| Lei, H; Li, L; Liu, DM; Peng, Y; Wang, XL; Zhang, Y; Zhao, CY | 1 |
| Yang, C; Zhang, Y; Zhu, J | 1 |
| Guo, B; Li, X; Li, Y; Wang, X; Zhang, T; Zhao, J; Zhao, L | 1 |
| Chen, L; Ding, Z; Hu, L; Ye, J; Zhai, L; Zhang, S; Zhang, Y | 1 |
| Bi, MJ; Cheng, Y; Guo, Y; Kang, H; Li, Q; Lin, H; Qu, Y; Zou, Y | 1 |
| Hou, D; Jia, X; Li, X; Liao, S; Long, W; Tan, N; Wang, G; Zhang, W | 1 |
| Bi, M; Chen, Y; Cheng, Y; Guo, Y; Kang, H; Li, Q; Lin, H; Liu, Y; Zou, Y | 1 |
| Hua, K; Huang, ZJ; Ji, H; Li, TT; Sheng, X; Wang, LN; Zhang, YH | 1 |
| Chen, S; Chen, X; Chen, Y; Chu, L; Dong, W; Fang, B; Guo, H; Han, X; Huang, L; Jia, J; Jia, Q; Li, D; Liang, J; Lv, P; Niu, X; Peng, D; Peng, M; Song, H; Wang, K; Wei, C; Wu, J; Wu, L; Zhang, J; Zhou, A; Zuo, X | 1 |
| Huang, Q; Liu, X; Wei, X; Wu, Y | 1 |
| Lan, Z; Lei, M; Li, J; Liang, Z; Xu, W; Xu, X; Zhang, X; Zhao, C | 1 |
| Hua, K; Huang, Z; Ji, H; Sheng, X; Wang, X; Xu, J; Yang, C; Zhang, Y | 1 |
| Cai, J; Cui, DD; Lei, H; Li, J; Liu, DM; Peng, Y; Rong, XF; Wang, L; Wang, XL; Xu, SF; Yang, LC; Zhang, M | 1 |
| Hu, JP; Hu, P; Jiang, J; Li, Y; Zhao, Q | 1 |
| Guo, L; Niu, LJ; Qi, FM; Zhou, Y | 1 |
| Dey, S; Gadakh, SK; Sudalai, A | 1 |
| Du, R; Shi, ZB; Teng, JF; Wang, Y; Zhao, XY | 1 |
| Chen, XY; Diao, XX; Li, XL; Zhong, DF; Zhong, K | 1 |
| Bi, X; Hu, Y; Huang, X; Zhao, P; Zheng, H | 1 |
| Cai, J; Lei, H; Li, L; Li, PP; Peng, Y; Wang, L; Wang, XL; Xu, SF; Zhang, Y; Zhao, CY | 1 |
| Duan, H; Guo, X; Han, F; Jin, C; Li, H; Ma, J; Meng, L; Peng, Y; Sun, Y; Wang, F | 1 |
| Jiang, Y; Sun, L; Wang, J; Xuan, X | 1 |
| Cai, X; Hui, G; Li, X; Ni, J; Yun, W; Zhang, Q; Zhao, H; Zhou, X | 1 |
| Cai, JH; Wang, CY; Wang, T; Wang, X; Wang, ZY; Xie, JW; Xu, Y | 1 |
| Cui, W; Hu, H; Liu, B; Liu, D; Xie, R; Zuo, Y | 1 |
| Han, L; Liu, X; Wang, Q | 1 |
| Guo, JQ; Huang, XJ; Liu, HZ; Liu, Y; Qi, DS; Song, YJ; Tang, M; Wang, SL; Wang, YL; Wang, YW; Wen, XR; Wu, J; Zhang, F; Zhang, XB | 1 |
| Fang, J; Huang, Z; Ji, H; Ji, J; Lan, L; Peng, S; Wang, X; Xu, J; Yin, W; Zhang, Y | 1 |
| Ji, H; Ling, JJ; Ping, FF; Qian, J; Song, HZ; Wang, L; Wang, XL; Zhang, YH; Zhou, J | 1 |
| Chaithong, U; Champakaew, D; Chansang, A; Intirach, J; Jitpakdi, A; Junkum, A; Muangmoon, R; Pitasawat, B; Riyong, D; Tuetun, B; Wannasan, A | 1 |
| Li, J; Wang, WP; Wang, XL; Yin, HJ; Zhang, M | 1 |
| Huang, LJ; Peng, Y; Shi, S; Wang, XL; Xu, SF; Zhang, Y | 1 |
| Guo, ZF; Li, YS; Song, JG; Xu, YM; Zhang, P | 1 |
| LaManna, JC; Puchowicz, MA; Xu, K; Zhang, L | 1 |
| Liu, J; Liu, Y; Xie, A; Xiong, H; Xu, E; Zhao, J | 1 |
| Li, Y; Liu, Q; Wang, H; Wu, Q; Xu, C | 1 |
| Abdoulaye, IA; Guo, YJ | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Gui, Y; Niu, X; Wang, J; Yan, H; Yan, Z; Zhang, P | 1 |
| Ding, H; Ding, K; Li, L; Li, X; Liu, Z; Shi, X; Wang, H; Yang, Y; Zhou, M | 1 |
| Ling, JJ; Wang, XL; Wang, ZY; Yin, J; Zhang, YH | 1 |
| Li, X; Li, Y; Peng, Y; Rong, X; Tang, Y; Zhang, X | 1 |
| Jiang, C; Li, Y; Pang, J; Wang, B; Xiang, W; Xue, H; Zhang, J | 1 |
| Caslin, A; Chen, D; Gu, X; Lee, JH; Li, J; Wei, L; Yu, SP; Zhao, Y | 1 |
| Jin, HT; Li, J; Wang, AP; Wang, XL; Xu, SF | 1 |
| Cheng, X; Liang, Y; Luo, Y; Mu, X; Qu, H; Sun, Y; Wang, H; Zhao, C | 1 |
| He, W; Liu, Y; Tian, X; Yang, R | 1 |
| Dong, Y; Fan, M; Hu, M; Huai, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xu, J | 1 |
| Hao, JL; Liu, C; Liu, XF; Lu, CB; Lu, CW; Malik, TH; Shu, C; Xie, T; Zhou, DD | 1 |
| Feng, S; Gu, F; Hu, L; Mao, S; Zang, Y; Zhang, C; Zhao, S | 1 |
| Chen, J; Gao, Z; He, Z; Khor, S; Li, J; Lin, L; Mao, Y; Wang, Q; Wang, Z; Wu, F; Xiao, J; Xu, HZ; Zhang, H; Zhang, X; Zhen, Z; Zhou, Y | 1 |
| Chen, YH; Ge, BB; Jiang, MJ; Li, L; Liu, H; Qu, HD; Qu, XL; Xu, JJ; Xu, L | 1 |
| Feng, N; Li, J; Peng, Y; Wang, L; Wang, XL; Xu, SF | 1 |
| Huang, Y; Li, Z; Nan, G | 1 |
| Tian, Z; Wang, J; Wang, Y; Zhang, M; Zhou, Y | 1 |
| Fan, XH; Li, K; Luo, CJ; Ning, LP; Tang, SC; Xue, P; Zhang, KH | 1 |
| Fan, CX; Liu, HH; Liu, RZ; Nie, ZX; Pu, XP; Sun, Y; Zhang, ZL; Zhao, X | 1 |
| Dong, Y; Fan, M; Hu, M; Jia, Y; Jin, W; Liu, Z; Lv, P; Meng, N; Qi, Q; Xiao, Y; Xu, J; Zhang, D | 1 |
| Liu, ZG; Wang, SJ; Xiao, N; Yan, RY; Yao, GT | 1 |
| Han, D; He, Z; Hong, Z; Liu, Y; Tong, S; Wang, Q; Wu, F; Xiao, J; Xu, H; Yang, G; Zhang, H; Zhang, X; Zheng, B; Zhou, Y | 1 |
| Chen, Y; Ge, B; Jiang, M; Li, L; Wei, D; Xu, W; Ye, M; Yu, M; Zhang, L | 1 |
| Cao, H; Ding, C; Huang, L; Ma, J; Peng, Y; Qiu, H; Qiu, W; Wu, H | 1 |
| Bi, Y; Chen, L; Guo, L; Li, B; Shi, W; Wang, Y; Xia, Z | 1 |
| Ding, C; Ma, J; Qiu, H; Wu, H | 1 |
| Guo, C; Wang, CY; Wang, T; Wang, X; Wang, ZY; Xu, Y | 1 |
| Ma, QS; Ma, YB; Mi, LX; Nai, Y; Song, DJ; Zhang, LH; Zhao, YJ | 1 |
| Dai, Y; Guo, Y; Liu, N; Qin, J; Wu, C; Xu, R; Zhang, P | 1 |
| Lin, Z; Rao, X; Xuan, J; Zhang, Z | 1 |
| Huang, L; Lei, H; Li, J; Peng, Y; Wang, L; Wang, X; Xing, C; Xu, S; Yang, L; Zhang, Y | 1 |
| Li, W; Mamtilahun, M; Qin, C; Wang, L; Wang, Y; Yang, GY; Zhang, Z; Zhou, P | 1 |
| Bi, M; Ding, X; Li, Q; Tang, J; Wang, J; Wang, L; Zou, Y | 1 |
| Feng, Y; Huang, L; Ma, F; Peng, Y; Wang, S; Wang, X; Xing, C; Zhang, Y | 2 |
| Hai-Jing, D; Xiao-Li, C; Xiao-Yan, FU; Xue-Feng, L; Yuan, R; Zhi-Wang, W | 1 |
| Duan, HJ; Lin, XY; Ren, Y; Wang, RQ; Wang, YH; Wang, ZW | 1 |
| Dang, R; Guo, Y; Han, W; Jiang, P; Liao, D; Xu, P; Yang, M | 1 |
| Hu, NN; Liu, CF; Xie, CL; Zhu, BL; Zhu, XB | 1 |
| Chen, DP; Chen, MS; Chen, YG; Hou, SH; Hu, ZZ; Zhang, ZJ | 1 |
| Cao, L; Dang, R; Fu, Y; Han, W; Jiang, P; Liao, D; Wang, J; Xiang, D; Xu, P; Yao, D | 1 |
| Chen, RJ; Dong, YY; Huang, CK; Lin, ZF; Sun, R; Sun, W; Wang, Z; Ye, WJ; Zhang, XD | 1 |
| Bai, XM; Ji, SX; Li, J; Yuan, F; Zhang, LH; Zhang, SY | 1 |
| Chen, N; Feng, J; He, D; Li, B; Li, J; Luo, J; Luo, Y; Zhang, J; Zheng, X; Zhou, Z | 1 |
| Feng, ZM; Jiang, JS; Yang, YN; Zhang, PC; Zhang, X | 1 |
| Li, J; Liu, D; Wang, X; Zhang, X; Zhao, Y | 1 |
| Chen, X; Li, Z; Lu, J; Ma, L; Wang, R; Wu, C; Xu, Z; Ye, X; Zhao, Y | 1 |
| Ge, YL; Han, XQ; Huang, C; Liu, C; Meng, QL; Wang, HY; Wang, L; Wang, Y; Wang, YH; Zhang, PP | 1 |
| Huang, L; Li, W; Liang, J; Song, K; Wei, D; Xie, X | 1 |
| Liu, M; Lv, PY; Wang, B; Xing, HY; Ye, ZY | 1 |
| Feng, L; Lafuente, JV; Muresanu, DF; Niu, F; Nozari, A; Ozkizilcik, A; Sharma, A; Sharma, HS; Tian, ZR | 1 |
| Liu, C; Shao, BZ; Xu, ZQ; Zhang, JJ; Zhou, Y | 1 |
| Cheng, X; Liu, C; Niu, X; Qi, R; Qu, H; Wang, H; Zhang, X; Zhao, C; Zhao, S; Zhong, S | 1 |
| Dong, L; Huang, Q; Liao, Y; Sun, L; Tang, Y; Wu, Y | 1 |
| Feng, XF; Qi, YY; Qiu, L; Yang, F | 1 |
| Li, L; Li, YP; Pei, Z; Wei, H; Zhan, LP; Zhang, B | 1 |
| Gong, Q; Li, X; Song, L; Xue, Y; Zhu, L | 1 |
| Dong, L; Huang, L; Li, X; Liu, X; Lv, Y; Su, R; Xing, X | 1 |
| Chen, Q; Li, M; Lin, W; Zhang, X; Zhong, R | 1 |
| Bai, JH; Chen, XQ; He, Q; Liu, H; Lu, W; Qiu, K | 1 |
| Hu, N; Jiang, W; Liu, L; Shi, L; Wang, Q; Yan, T; Yang, P; Zhang, S; Zhang, W | 1 |
| Chen, R; Gao, X; Li, J; Liu, Y; Xue, J; Zhang, L; Zhang, X | 1 |
| Cao, X; Dai, YT; Han, LJ; Han, QY; He, DS; Wang, SW; Xu, Y; Zhang, H; Zhang, X | 1 |
| Feng, L; Muresanu, DF; Niu, F; Nozari, A; Sahib, S; Sharma, A; Sharma, HS; Tian, ZR | 1 |
| Cheng, W; Dong, LF; Liao, W; Zhong, Y | 1 |
| Ding, M; Fu, X; Guo, M; Liu, D; Pang, Y; Ren, Y; Wang, Z; Wei, L; Yao, N | 1 |
| Chen, J; Chen, L; He, J; Liu, N; Sun, Q; Wang, L; Wang, X; Yang, L; Zhao, J; Zhao, Y | 1 |
| Jiang, M; Lu, S; Lyu, Y; Nie, T; Qian, Y; Tang, B | 1 |
| Dong, YT; Hu, FY; Li, TT; Liu, Y; Zhang, XL; Zhang, Y | 1 |
| Bai, M; Jiang, GX; Pan, CL; Zhang, YM; Zhang, Z | 1 |
| Li, ZX; Luo, H; Rong, BB; Wang, FT; Xu, XM; Zhang, SJ; Zheng, XM | 1 |
| Gu, F; Hu, L; Li, H; Song, Q; Zang, Y; Zhang, C; Zhang, Q; Zhao, W | 1 |
| Chen, D; Chen, Z; Liu, L; Teng, C; Wu, F; Wu, Y; Xia, L; Xiao, J; Xu, K; Zhang, H; Zhang, K; Zhang, M | 1 |
| Gao, TC; Hu, Y; Kang, LJ; Li, P; Qi, FX; Zhang, X | 1 |
| Deng, S; Lei, Q; Liu, H; Lu, W; Qiu, K; You, H | 1 |
| Bai, S; Chen, Z; Qi, X; Wang, T; Wang, W; Xie, P | 1 |
| Bao, Y; Liu, G; Wang, Y; Wu, H; Zhang, M; Zhou, S | 1 |
| Chen, G; Deng, Y; Jiang, W; Li, X; Shangguan, S; Zhou, F; Zou, W | 1 |
| He, XJ; Wang, L; Wu, JP | 1 |
| Liu, JX; Ren, JG; Wang, M; Yao, MJ | 1 |
| Chen, Y; Guo, Y; Li, G; Li, W; Zhang, J | 1 |
| Dent, EW; Duan, LX; Jamornwan, S; Saengsawang, W; Sunrat, C; Uppakara, K; Wan, SB; Yue, KR | 1 |
| Li, H; Li, W; Tian, A; Zai, Q; Zhang, RW | 1 |
| Jia, LN; Ma, R; Song, Y; Zhang, YJ | 1 |
| Chen, D; Li, B; Li, W; Shi, J; Wang, K; Yang, F; Yin, Y; Zhao, F | 1 |
| Chen, D; Geng, C; Guo, Y; Han, W; Hao, G; Jiang, P; Yang, M; Yi, Q; Zhang, J | 1 |
| Chen, Q; Tan, L; Tu, E; Wang, Y | 1 |
| Gong, X; Hu, Z; Zeng, Z | 1 |
| Ge, X; Li, Q; Qin, Y; Sun, Y; Wang, C; Wang, G; Wang, X; Zhao, Z | 1 |
| Marco-Contelles, J; Zhang, Y | 1 |
| Fang, M; Fu, X; Hu, Y; Jiang, H; Jiang, S; Li, P; Lin, J; Lin, Z; Pan, S; Yuan, J; Zhu, J | 1 |
| Ding, Y; Gu, Z; Liu, Y; Niu, J; Wang, W; Wei, C; Zhai, T; Zhang, Y | 1 |
| Feng, Y; Gao, P; Gui, L; Pan, W; Qin, B; Sima, D; Wang, J; Wang, M; Wang, Q; Yuan, Y | 1 |
| Liu, L; Qu, M; Sun, J; Wei, L; Zhang, Y; Zhao, J; Zhao, Y | 1 |
| Gao, YL; Guo, JJ; Wang, M; Wang, ZY; Yu, XF | 1 |
| Ma, Y; Sun, W | 1 |
| Feng, X; Huang, L; Kang, Y; Lan, J; Peng, Y; Tang, J; Wu, L | 1 |
| Huang, Y; Pan, L; Wu, T | 1 |
| Wu, F; Yang, R; Zhou, L | 1 |
| Gao, Q; Li, W; Liu, H; Tan, S; Xiang, H; Xie, L; Zhang, B; Zhuo, Y | 1 |
| Buzoianu, AD; Castellani, RJ; Feng, L; Lafuente, JV; Muresanu, DF; Niu, F; Nozari, A; Patnaik, R; Sahib, S; Sharma, A; Sharma, HS; Tian, ZR; Wang, Z; Wiklund, L | 1 |
| Cui, L; He, W; Liu, H; Zhang, C; Zhang, X | 1 |
| Fu, D; Liu, R; Liu, X; Pu, X; Sun, Y; Wang, M; Wu, H; Zhao, X | 1 |
| Chen, ZM; Li, PF; Liu, YQ; Mamun, AA; Wang, BN; Wang, J; Wu, CB; Wu, YQ; Xiao, J; Xiong, J; Xu, JY; Ye, LB; Zheng, PP; Zheng, ZL | 1 |
| Gao, F; Guo, X; Liu, J; Lu, W; Ma, L; Qu, Q; Quan, Q; Su, H; Wang, J; Zhang, H | 1 |
| Chen, J; E, GJ; Gao, YQ; He, S; Hu, Q; Liu, B; Liu, L; Shi, YK; Sun, BD; Xu, G; Zhang, EL; Zhang, JY | 1 |
| Guo, Y; Li, X; Miao, L; Tian, H; Wang, X; Yuan, R | 1 |
| Chen, T; Dong, Y; Fan, Y; Li, X; Lin, W; Liu, F; Wang, N; Wen, J; Yin, J; Zhang, Q | 1 |
| Guo, Y; Li, X; Lin, X; Liu, Y; Miao, L; Tian, H; Wang, X; Yuan, R | 1 |
| Bi, K; Cang, S; Li, Q; Li, W; Li, Z; Liu, R; Sun, Z | 1 |
| Huo, X; Jia, B; Miao, Z; Tian, X; Wang, A; Wang, Y; Zhang, JY; Zhang, X; Zuo, Y | 1 |
| Lin, LL; Lin, LS; Lin, T; Wu, YA | 1 |
| Cui, H; Liang, Z; Liu, Y; Shao, F; Shi, X; Tang, Z; Wu, Y; Yang, S; Yang, Z; Yu, C; Zhao, S | 1 |
| Hong, Z; Jin, Y; Mi, S; Wang, Z; Xu, W; Yang, X; Zheng, B | 1 |
| Han, Y; Liu, Q; Xiang, H; Yang, L; Zhang, L; Zhang, Q; Zhang, Y; Zhang, Z | 1 |
| Hu, Z; Liu, J; Pi, Z; Xiao, H | 1 |
| Harn, HJ; Lin, SZ; Lin, WJ; Liu, SP; Lu, KY; Primus Dass, KT | 1 |
| Luo, L; Shan Huang, S; Wei Mo, S; Xian Zeng, G; Zhou, B | 1 |
| Cai, ZY; Chen, F; Qi, YW; Yuan, MH; Zheng, YL | 1 |
| Chang, H; Li, H; Wang, D; Yin, A; Yin, J | 1 |
| Chen, C; Fu, Z; Ma, H | 1 |
| Abdoulaye, IA; Guo, Y; Le, K; Liu, F; Tian, X; Wang, J; Yu, D | 1 |
| Diao, X; Ge, X; He, Y; Lei, P; Luo, L; Tian, J; Yan, S; Zhang, N | 1 |
| Chai, A; Gao, Y; Li, C; Qi, X; Zheng, X | 1 |
| Cheng, Y; Guan, Y; Guo, L; Li, P; Liu, Y; Wu, Q | 1 |
| Chu, Z; He, G; Hu, M; Huang, Y; Li, J; Ma, X; Xu, Q; Zhang, Y; Zhu, P; Zhu, Q | 1 |
| Diao, X; Huang, H; Lei, P; Liu, M; Ren, X; Wan, M; Xue, Y; Zhong, D; Zhu, Z | 1 |
| Li, J; Li, Q; Meng, H; Wang, C; Wang, S; Wu, Z; Xu, Y; Zhang, A; Zhang, J | 1 |
| Chen, Y; Du, J; Li, H; Wu, Y; Yang, L; Zhang, H | 1 |
| Chen, L; Huang, S; Lin, C; Yao, T; Yuan, H; Zhang, J | 1 |
| Chang, Z; Huang, Z; Jin, D; Li, H; Que, R; Tan, EK; Wang, HT; Wang, Q; Xie, Z; Xu, J; Yang, W; Zhang, W; Zheng, J | 1 |
| Luo, Y; Zhao, F | 1 |
| Liu, F; Shi, W; Wang, J; Zhang, X; Zhao, S; Zhou, Z | 1 |
| Dong, Y; Gao, L; Guo, X; Hu, M; Liu, S; Lv, P; Qin, X; Sun, Q; Xu, J | 1 |
| Chen, G; Huang, L; Liang, J; Song, K; Xie, X; Zeng, X; Zhu, R | 1 |
| Che, F; Dong, X; Feng, L; Jing, R; Pei, Q; Qian, J; Ren, G; Xue, L | 1 |
| Chen, Y; Han, B; Han, J; Lin, W; Shi, X; Wang, Y; Xu, J | 1 |
| Jia, JP; Li, BQ; Li, FY; Li, Y; Quan, MN; Xu, LZ; Zhang, H; Zhao, Y | 1 |
| Chen, X; Deng, S; Lu, W; Ren, Y; Zhang, Y | 1 |
| Li, K; Lu, X; Yao, S; Zhang, Q | 1 |
| Guo, Y; Hu, H; Liu, H; Liu, Y; Xu, G; Yan, J | 1 |
| Li, G; Liu, W; Meng, H; Ruan, L; Wang, J; Yu, J; Zhang, L; Zhong, X; Zhu, M | 1 |
| Huang, Z; Ji, D; Jia, J; Jiao, W; Wang, X; Wu, J; Zhang, Y | 1 |
| Fu, B; Gao, G; Meng, S | 1 |
| Cao, L; Han, W; Sun, GB; Xiao, HY; Yang, SX | 1 |
| Dai, J; Lin, Q; Miao, H; Sun, Y; Wang, J; Wang, X; Yan, L; Zhang, Y | 1 |
| Lv, J; Xie, Z; Zhao, D; Zhao, G | 1 |
| Chi, X; Han, C; Hu, J; Huang, J; Kou, L; Li, Y; Sun, Y; Wan, F; Wang, T; Wu, J; Xia, Y; Yin, S; Zhou, Q; Zou, W | 1 |
| Shen, J; Wei, W; Yang, L | 1 |
| Gao, Y; Malik, TH; Tan, SW; Xie, T | 1 |
| Cui, L; Fan, D; He, J; Huang, X; Liu, M; Shang, H; Yao, X | 1 |
| Hu, B; Hu, F; Qiao, Y | 1 |
| Hong, Z; Li, S; Li, Y; Liu, Y; Wang, J; Xie, S | 1 |
14 review(s) available for 3-n-butylphthalide and benzofurans
| Article | Year |
|---|---|
Recent pharmacological studies on natural products in China.
Topics: Alkaloids; Animals; Benzofurans; Berberine; China; Cholinesterase Inhibitors; Diterpenes; Dopamine Agonists; Dopamine Antagonists; Drugs, Chinese Herbal; Epoxy Compounds; Ginkgo biloba; Humans; Immunosuppressive Agents; Lactams; Lignans; Neuroprotective Agents; Phenanthrenes; Rutaceae; Sesquiterpenes | 2004 |
A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives.
Topics: Apium; Apoptosis; Benzofurans; Humans; Inflammation; Nervous System Diseases; Neuroprotective Agents; Oxidative Stress; Plant Extracts | 2016 |
Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress.
Topics: Aging; Antioxidants; Benzofurans; Blindness; Cataract; Flavonoids; Gene Expression Regulation, Developmental; Humans; Kelch-Like ECH-Associated Protein 1; Lens, Crystalline; NF-E2-Related Factor 2; Oxidative Stress; Quercetin; Signal Transduction; Transcription, Genetic | 2017 |
Dl-3-n-Butylphthalide (NBP): A Promising Therapeutic Agent for Ischemic Stroke.
Topics: Animals; Benzofurans; Brain Ischemia; Humans; Platelet Aggregation Inhibitors; Stroke | 2018 |
From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives.
Topics: Animals; Benzofurans; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Stroke | 2018 |
Nanowired delivery of DL-3-n-butylphthalide induces superior neuroprotection in concussive head injury.
Topics: Animals; Benzofurans; Brain Concussion; Brain Edema; Humans; Nanomedicine; Nanowires; Neuroprotective Agents | 2019 |
A Systematic Review of Neuroprotective Efficacy and Safety of DL-3-N-Butylphthalide in Ischemic Stroke.
Topics: Aged; Benzofurans; Brain Ischemia; Databases, Bibliographic; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Phytotherapy; Randomized Controlled Trials as Topic; Stroke; Treatment Outcome | 2019 |
L-3-n-butylphthalide soft capsules in the treatment of Parkinson disease dementia: A systematic review and meta-analysis of randomized controlled trials.
Topics: Antiparkinson Agents; Benzofurans; Capsules; Dementia; Humans; Nootropic Agents; Parkinson Disease; Randomized Controlled Trials as Topic | 2019 |
Application and prospects of butylphthalide for the treatment of neurologic diseases.
Topics: Animals; Benzofurans; Humans; Nervous System Diseases; Neuroprotective Agents; Oxidative Stress | 2019 |
Management of delayed encephalopathy after CO poisoning: An evidence-based narrative review.
Topics: Benzofurans; Brain Diseases; Carbon Monoxide Poisoning; Dexamethasone; Drugs, Chinese Herbal; Humans; Hyperbaric Oxygenation; Mesenchymal Stem Cell Transplantation; Randomized Controlled Trials as Topic; Time Factors | 2019 |
[Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia].
Topics: Benzofurans; Brain Ischemia; Cerebral Infarction; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Neuroprotective Agents; Panax notoginseng; Pyrazines; Saponins | 2020 |
Role of Butylphthalide in Immunity and Inflammation: Butylphthalide May Be a Potential Therapy for Anti-Inflammation and Immunoregulation.
Topics: Anti-Inflammatory Agents; Benzofurans; Humans; Inflammation; Neuroprotective Agents | 2022 |
Efficacy and safety of 3-n-butylphthalide for the treatment of cognitive impairment: A systematic review and meta-analysis.
Topics: Benzofurans; Cognition; Cognition Disorders; Cognitive Dysfunction; Humans | 2022 |
Advances of neurovascular protective potential of 3-N-butylphthalide and its derivatives in diabetic related diseases.
Topics: Benzofurans; Diabetes Complications; Diabetes Mellitus; Humans; Oxidative Stress | 2022 |
19 trial(s) available for 3-n-butylphthalide and benzofurans
| Article | Year |
|---|---|
Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation.
Topics: Administration, Oral; Adult; Alcohol Dehydrogenase; Animals; Benzofurans; Biotransformation; Cardiovascular Agents; Chromatography, Liquid; Cunninghamella; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Intestinal Absorption; Isoenzymes; Kidney; Liver; Male; Metabolomics; Molecular Structure; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Young Adult | 2013 |
Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial.
Topics: Adult; Aged; Benzofurans; Double-Blind Method; Female; Humans; Male; Middle Aged; Stroke; Treatment Outcome | 2013 |
The effects of DL-3-n-butylphthalide in patients with vascular cognitive impairment without dementia caused by subcortical ischemic small vessel disease: A multicentre, randomized, double-blind, placebo-controlled trial.
Topics: Aged; Benzofurans; Cerebral Small Vessel Diseases; China; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests | 2016 |
Clinical study of Butylphthalide combined with Xue Shuan Tong on serum inflammatory factors and prognosis effect of patients with cerebral infarction.
Topics: Aged; Aged, 80 and over; Benzofurans; Calcitonin Gene-Related Peptide; Carotid Arteries; Carotid Intima-Media Thickness; Cerebral Infarction; Drugs, Chinese Herbal; Female; Humans; Inflammation; Interleukin-2; Male; Middle Aged; Nervous System Diseases; Plaque, Atherosclerotic; Prognosis | 2015 |
Combination of butylphthalide with umbilical mesenchymal stem cells for the treatment of delayed encephalopathy after carbon monoxide poisoning.
Topics: Adult; Analysis of Variance; Benzofurans; Brain Diseases; Carbon Monoxide Poisoning; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Mesenchymal Stem Cell Transplantation; Middle Aged; Prospective Studies; Reference Values; Risk Assessment; Severity of Illness Index; Survival Rate; Tomography, X-Ray Computed; Treatment Outcome | 2016 |
Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.
Topics: Acute Disease; Benzofurans; Brain Diseases; Carbon Monoxide Poisoning; Cognitive Dysfunction; Demography; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Neuropsychological Tests; Remission Induction; Treatment Outcome | 2017 |
The efficacy and safety of Dl-3n-butylphthalide on progressive cerebral infarction: A randomized controlled STROBE study.
Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Benzofurans; Cerebral Infarction; Disability Evaluation; Disease Progression; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Severity of Illness Index; Time Factors; Treatment Outcome | 2017 |
Effects of dl-3-n-butylphthalide on serum VEGF and bFGF levels in acute cerebral infarction.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Benzofurans; Cerebral Infarction; Female; Fibroblast Growth Factor 2; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Vascular Endothelial Growth Factor A; Young Adult | 2017 |
Economic evaluation of human urinary kallindinogenase for patients with acute ischemic stroke in China.
Topics: Benzofurans; Cerebrovascular Circulation; China; Cost-Benefit Analysis; Female; Health Services; Humans; Male; Models, Econometric; Prospective Studies; Quality-Adjusted Life Years; Stroke | 2018 |
Human urinary kallidinogenase or edaravone combined with butylphthalide in the treatment of acute ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Brain Ischemia; Drug Therapy, Combination; Edaravone; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Kallikreins; Treatment Outcome; Young Adult | 2019 |
Effects of dl-3-n-butylphthalide on serum lipoprotein-associated phospholipase A2 and hypersensitive C-reactive protein levels in acute cerebral infarction.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Acute Disease; Benzofurans; C-Reactive Protein; Cerebral Infarction; Drug Monitoring; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Treatment Outcome | 2019 |
Effects of butylphthalide injection on treatment of transient ischemic attack as shown by diffusion-weighted magnetic resonance imaging abnormality.
Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Brain Infarction; Diffusion Magnetic Resonance Imaging; Female; Humans; Injections; Ischemic Attack, Transient; Male; Middle Aged; Neuroprotective Agents; Outcome Assessment, Health Care; Severity of Illness Index | 2020 |
Effects of Butyphthalide Combined with Idebenone on Inflammatory Cytokines and Vascular Endothelial Functions of Patients with Vascular Dementia.
Topics: Activities of Daily Living; Aged; Antioxidants; Benzofurans; C-Reactive Protein; Cytokines; Dementia, Vascular; Drug Therapy, Combination; Endothelin-1; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Ubiquinone; Vascular Endothelial Growth Factor A | 2020 |
DL-3-n-butylphthalide improves cerebral hypoperfusion in patients with large cerebral atherosclerotic stenosis: a single-center, randomized, double-blind, placebo-controlled study.
Topics: Benzofurans; Double-Blind Method; Humans; Intracranial Arteriosclerosis; Neuroprotective Agents | 2020 |
Efficacy and safety of butylphthalide for patients who had acute ischaemic stroke receiving intravenous thrombolysis or endovascular treatment (BAST trial): study protocol for a randomised placebo-controlled trial.
Topics: Benzofurans; Brain Ischemia; Double-Blind Method; Humans; Ischemic Stroke; Randomized Controlled Trials as Topic; Stroke; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome | 2021 |
Efficacy of sequential N-butylphthalide therapy on psychiatric and behavioral functions in acute ischemic stroke.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Behavioral Symptoms; Benzofurans; Double-Blind Method; Female; Humans; Ischemic Stroke; Male; Mental Disorders; Middle Aged; Treatment Outcome | 2021 |
Efficacy and safety of butylphthalide in secondary prevention of stroke: study protocol for a multicenter, real world trial based on Internet.
Topics: Aspirin; Benzofurans; Clopidogrel; Double-Blind Method; Humans; Internet; Ischemic Stroke; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome | 2022 |
Dl-3-n-butylphthalide prevents chronic restraint stress-induced depression-like behaviors and cognitive impairment via regulating CaMKII/CREB/BDNF signaling pathway in hippocampus.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cognitive Dysfunction; Cyclic AMP Response Element-Binding Protein; Depression; Hippocampus; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Signal Transduction; Synaptophysin | 2022 |
A multicenter, randomized, double blind, placebo-controlled clinical trial of DL-3-n-butylphthalide in treatment of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Benzofurans; Double-Blind Method; Humans; Treatment Outcome | 2023 |
263 other study(ies) available for 3-n-butylphthalide and benzofurans
| Article | Year |
|---|---|
[Studies on the structure of a phthalide compound (author's transl)].
Topics: Benzofurans; Chemical Phenomena; Chemistry; Plants, Medicinal | 1979 |
[Facilitated performance of learning and memory in rats by 3-n-butyl phthalide].
Topics: Animals; Avoidance Learning; Benzofurans; Epilepsy; Female; Hippocampus; Lactones; Memory; Rats; Rats, Inbred Strains | 1988 |
[The protective effect of 3-butyl phthalide on rat brain cells].
Topics: Animals; Anticonvulsants; Benzofurans; Brain; Epilepsy; Female; Lactones; Rats; Rats, Inbred Strains | 1988 |
[The anticonvulsant action of 3-n-butylphthalide (Ag-1) and 3-n-butyl-4, 5-dihydrophthalide (Ag-2)].
Topics: Animals; Anticonvulsants; Benzofurans; China; Electroshock; Female; Male; Mice; Plants, Medicinal; Rats; Structure-Activity Relationship | 1984 |
[Effect of DL-butylphthalide (NBP) on mouse brain energy metabolism in complete brain ischemia induced by decapitation].
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Benzofurans; Brain; Brain Ischemia; Decerebrate State; Energy Metabolism; Female; Lactates; Male; Mice; Phosphocreatine | 1995 |
[Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia].
Topics: Animals; Behavior, Animal; Benzofurans; Cerebral Infarction; Dizocilpine Maleate; Male; Neuroprotective Agents; Nimodipine; Rats; Rats, Wistar; Vasodilator Agents | 1995 |
[Effect of dl-3-n-butylphthalide (NBP) on purine metabolites in striatum extracellular fluid in four-vessel occlusion rats].
Topics: Adenosine; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Extracellular Space; Inosine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion; Stereoisomerism; Xanthines | 1996 |
[Effect of dl-3-n-butylphthalide (NBP) on life span and neurological deficit in SHRsp rats].
Topics: Animals; Benzofurans; Blood Pressure; Body Weight; Cerebrovascular Disorders; Heart Rate; Male; Neuroprotective Agents; Nimodipine; Rats; Rats, Inbred SHR; Stereoisomerism | 1996 |
Effects of celery extract and 3-N-butylphthalide on lipid levels in genetically hypercholesterolaemic (RICO) rats.
Topics: Animals; Benzofurans; Cholesterol; Cholesterol, HDL; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lipoproteins; Liver; Plant Extracts; Rats; Triglycerides; Vegetables | 1996 |
[Effect of dl-3-butylphthalide on the striatum extracellular amino acid and dopamine contents in the rat during cerebral ischemia].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzofurans; Brain Ischemia; Corpus Striatum; Dopamine; Extracellular Space; Glycine; Male; Neuroprotective Agents; Rats; Rats, Wistar | 1996 |
[Investigation on in vivo metabolism of n-butyl phthalide].
Topics: Animals; Benzofurans; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Wistar | 1996 |
Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Benzofurans; Brain; Ischemic Attack, Transient; Neuroprotective Agents; Rats; Reperfusion Injury; Thromboxane B2 | 1997 |
Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats.
Topics: Animals; Benzofurans; Cerebrovascular Circulation; Corpus Striatum; Drugs, Chinese Herbal; Ischemic Attack, Transient; Male; Neuroprotective Agents; Nimodipine; Rats; Rats, Wistar; Vasodilator Agents | 1998 |
dl-3-n-butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Capillaries; Capillary Permeability; Cerebral Cortex; Immunoglobulin G; Ischemic Attack, Transient; Male; Microscopy, Electron; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 1999 |
dl-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats.
Topics: Animals; Benzofurans; Caudate Nucleus; Male; Neuroprotective Agents; Rats; Rats, Wistar; Regional Blood Flow; Subarachnoid Hemorrhage | 1999 |
Protective effects of dl-3-n-butylphthalide on changes of regional cerebral blood flow and blood-brain barrier damage following experimental subarachnoid hemorrhage.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Caudate Nucleus; Male; Neuroprotective Agents; Rats; Rats, Wistar; Regional Blood Flow; Subarachnoid Hemorrhage | 1998 |
Effects of 3-n-butylphthalide on production of vasoactive substances by cerebral and aortic endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Aorta; Benzofurans; Cattle; Cells, Cultured; Cerebral Cortex; Endothelin-1; Endothelium, Vascular; Epoprostenol; Neuroprotective Agents; Nitric Oxide; Stereoisomerism | 1999 |
Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats.
Topics: Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Infarction, Middle Cerebral Artery; Inflammation; Intercellular Adhesion Molecule-1; Leukocyte Count; Male; Neuroprotective Agents; Neutrophils; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
Effect of dl-3-n-butylphthalide on brain edema in rats subjected to focal cerebral ischemia.
Topics: Animals; Benzofurans; Brain Edema; Drugs, Chinese Herbal; Hypoxia-Ischemia, Brain; Male; Neuroprotective Agents; Rats; Rats, Wistar | 1997 |
[Effects of 3-N-butylphthalide on cortical calcineurin and calpain activities in focal cerebral ischemia rats].
Topics: Animals; Benzofurans; Brain Ischemia; Calcineurin; Calpain; Cerebral Cortex; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury | 2000 |
[Protective effects of D-3-N-butylphthalide and L-3-N-butylphthalide on neuronal damage induced by KCl and NMDA in cultured rat cortical neurons].
Topics: Animals; Benzofurans; Cell Death; Cells, Cultured; Cerebral Cortex; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Chloride; Rats; Rats, Wistar; Stereoisomerism | 1997 |
[A study on the metabolites of dl-3-n-butyphthalide in rats].
Topics: Animals; Benzofurans; Brain; Feces; Male; Neuroprotective Agents; Rats; Rats, Wistar | 1997 |
dl-3-n-butylphthalide reduces brain damage in mice with closed head injury.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain Edema; Brain Injuries; Head Injuries, Closed; Male; Mice; Neuroprotective Agents | 2000 |
[Protective effects of dl-3-n-butylphthalide on changes of regional cerebral blood flow and blood-brain barrier after subarachnoid hemorrhage].
Topics: Animals; Benzofurans; Blood-Brain Barrier; Cerebrovascular Circulation; Drugs, Chinese Herbal; Male; Neuroprotective Agents; Rats; Rats, Wistar; Subarachnoid Hemorrhage | 1998 |
[Effects of butylphthalide on extracellular 6-keto-PGF1 alpha, TXB2 and 6-keto-PGF1 alpha/TXB2 ratio in cultured rat cortical neurons].
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Drugs, Chinese Herbal; Female; Fetus; Glucose; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Thromboxane B2 | 1998 |
[Protective effects of d-, l-, and dl-3-n-butylphthalide on neuronal damage induced by hypoxia/hypoglycemia in cultured rat cortical neurons].
Topics: Animals; Benzofurans; Cell Death; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Female; Fetus; Hypoglycemia; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Polyribosomes; Rats; Rats, Wistar; Stereoisomerism | 1998 |
[Effect of dl-3-N-butylphthalide on the expression of hsp70 mRNA and c-fos in transient cerebral ischemic and reperfused rat brain].
Topics: Animals; Benzofurans; HSP70 Heat-Shock Proteins; Ischemic Attack, Transient; Male; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Stereoisomerism | 1998 |
[Effects of d-3-n-butylphthalide and l-3-n-butylphthalide on extracellular no level and intracellular cGMP level in primary cultured rat cortical neurons].
Topics: Animals; Benzofurans; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Female; Fetus; Neurons; Neuroprotective Agents; Nitric Oxide; Rats; Rats, Wistar; Stereoisomerism | 1998 |
[Effects of 3-n-butylphthalide on thrombosis formation and platelet function in rats].
Topics: Animals; Benzofurans; Blood Platelets; Cyclic AMP; Fibrinolytic Agents; Male; Neuroprotective Agents; Platelet Aggregation; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Serotonin; Stereoisomerism; Thrombosis | 2001 |
Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats.
Topics: Animals; Apoptosis; Benzofurans; Caspase 3; Caspases; Cytochromes c; DNA Fragmentation; Drugs, Chinese Herbal; Ischemic Attack, Transient; Male; Neuroprotective Agents; Rats; Rats, Wistar; Stereoisomerism | 2003 |
[Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats].
Topics: Adenosine Triphosphatases; Animals; Benzofurans; Cerebral Cortex; Drugs, Chinese Herbal; Glutathione Peroxidase; Ischemic Attack, Transient; Lipid Peroxidation; Male; Mitochondria; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase | 2002 |
Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats.
Topics: Animals; Benzofurans; Bleeding Time; Fibrinolytic Agents; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombosis | 2004 |
Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines.
Topics: 4-Butyrolactone; Benzofurans; Cell Extracts; Cells, Cultured; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Endothelial Cells; Humans; Isoflavones; Mass Spectrometry | 2006 |
2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia.
Topics: Animals; Benzoates; Benzofurans; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Laser-Doppler Flowmetry; Male; Neuroprotective Agents; Pentanes; Prodrugs; Rats; Rats, Sprague-Dawley | 2006 |
l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Acetylcholinesterase; Animals; Astrocytes; Benzofurans; Brain Ischemia; Carotid Artery, Common; Catalase; Cerebral Cortex; Choline O-Acetyltransferase; Cognition Disorders; Corpus Callosum; Glutathione Peroxidase; Hippocampus; Learning Disabilities; Ligation; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Visual Pathways | 2007 |
dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP.
Topics: Animals; Aspirin; Benzofurans; Brain; Brain Ischemia; Cerebral Arteries; Cerebrovascular Circulation; Cold Temperature; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hypertension, Renal; Male; Microcirculation; Molecular Structure; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Treatment Outcome | 2007 |
[The effect of butylphthalide on expression of NGF and BDNF in ischemia stroke tissue of rat cerebrum].
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cerebrum; Gene Expression Regulation; Ischemia; Male; Nerve Growth Factor; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stroke | 2007 |
l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells.
Topics: Amyloid beta-Peptides; Animals; Apium; Apoptosis; Benzofurans; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Interactions; Hippocampus; Humans; Neuroblastoma; Neurons; Neuroprotective Agents; Peptide Fragments; Plant Extracts; Rats; Rats, Sprague-Dawley | 2008 |
[Effects of dl-3-n-butylphthalide on expression of VEGF and bFGF in rat brain with permanent focal cerebral ischemia].
Topics: Animals; Benzofurans; Brain; Brain Ischemia; Drugs, Chinese Herbal; Fibroblast Growth Factor 2; Infarction, Middle Cerebral Artery; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2008 |
High-performance liquid chromatography for the determination of 3-n-butylphthalide in rat plasma by tandem quadrupole mass spectrometry: application to a pharmacokinetic study.
Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Male; Rats; Rats, Wistar; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
[Mechanism of action of butylphalide against the injury following oxygen glucose deprivation/reoxygenation in rat cortical neurons].
Topics: Animals; Animals, Newborn; Antioxidants; Benzofurans; Cell Hypoxia; Cerebral Cortex; Drugs, Chinese Herbal; Female; Glucose; L-Lactate Dehydrogenase; Male; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type II; Pyrrolidines; Rats; Rats, Wistar; RNA, Messenger; Thiocarbamates; Transcription Factor RelA | 2008 |
Novozyme 435-catalyzed efficient acylation of 3-n-butylphthalide in organic medium.
Topics: Acylation; Benzofurans; Catalysis; Enzymes, Immobilized; Fungal Proteins; Kinetics; Lipase; Organic Chemicals | 2008 |
Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats.
Topics: Aging; Animals; Benzofurans; Dose-Response Relationship, Drug; Female; Male; Nerve Degeneration; Rats; Rats, Wistar; Time Factors | 2009 |
Novozyme 435-catalyzed asymmetric acylation of (R, S)-3-n- butylphthalide in hexane.
Topics: Acylation; Benzofurans; Catalysis; Chromatography, High Pressure Liquid; Enzymes, Immobilized; Fungal Proteins; Hexanes; Kinetics; Lipase; Stereoisomerism; Temperature | 2009 |
Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP.
Topics: Angiogenesis Inducing Agents; Animals; Benzofurans; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Drugs, Chinese Herbal; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neovascularization, Physiologic; Rats; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
DL-3-n-butylphthalide protects endothelial cells against oxidative/nitrosative stress, mitochondrial damage and subsequent cell death after oxygen glucose deprivation in vitro.
Topics: Benzofurans; Blotting, Western; Cell Death; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Fluorescent Antibody Technique; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitochondria; Neuroprotective Agents; Oxidative Stress; Oxygen; Superoxide Dismutase | 2009 |
[Effects of dl-3n-butylphthalide on the expression of VEGF and bFGF in transient middle cerebral artery occlusion rats].
Topics: Animals; Benzofurans; Fibroblast Growth Factor 2; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vascular Endothelial Growth Factor A | 2009 |
[Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by inhibiting P38 mitogen-activated protein kinase and enhancing extra-cellular signal regulated kinase expressions].
Topics: Alzheimer Disease; Animals; Benzofurans; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Hippocampus; Male; Memory; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley | 2009 |
[Effect of butylphthalide on the expression of S100 and glial fibrillary acidic protein in a rat model of Alzheimer disease].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzofurans; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Nerve Growth Factors; Neuroprotective Agents; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2009 |
L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in rats.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; Cerebral Ventricles; Cognition Disorders; Infusion Pumps; Learning; Male; Memory; Neurons; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Phosphorylation; Rats; Rats, Wistar; tau Proteins | 2009 |
Synthesis of chiral 3-substituted phthalides by a sequential organocatalytic enantioselective aldol-lactonization reaction. Three-step synthesis of (S)-(-)-3-butylphthalide.
Topics: Aldehydes; Benzofurans; Catalysis; Cyclization; Ketones; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2010 |
Synthesis and biological activity of n-butylphthalide derivatives.
Topics: Animals; Aorta, Thoracic; Benzofurans; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Rats; Stereoisomerism; Vasodilator Agents | 2010 |
[Effect of butylphthalide on the expression of GFAP and VEGF in the hippocampus of rats with Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Benzofurans; Disease Models, Animal; Drugs, Chinese Herbal; Glial Fibrillary Acidic Protein; Hippocampus; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2010 |
[IR and Raman spectroscopic studies on the derivatives of butylphthalide].
Topics: Benzofurans; Spectrophotometry, Infrared; Spectrum Analysis, Raman | 2010 |
dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; alpha-Synuclein; Animals; Antioxidants; Apium; Benzofurans; Cell Survival; Cytoprotection; Glutathione; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Parkinson Disease, Secondary; PC12 Cells; Rats; Reactive Oxygen Species | 2010 |
3-n-Butylphthalide (NBP) reduces apoptosis and enhances vascular endothelial growth factor (VEGF) up-regulation in diabetic rats.
Topics: Animals; Apoptosis; Benzofurans; Cerebral Arteries; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Gliosis; Hippocampus; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stroke; Up-Regulation; Vascular Endothelial Growth Factor A | 2010 |
L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer's disease.
Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Line, Tumor; Cell Survival; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indoles; Leukocyte Common Antigens; Male; Maleimides; Malondialdehyde; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neuroblastoma; Neuroglia; Neuroprotective Agents; Oxidative Stress; Presenilin-1; Reaction Time; Spatial Behavior; Statistics, Nonparametric; tau Proteins; Time Factors; Transfection | 2010 |
Protective effect of 3-butyl-6-bromo-1(3H)-isobenzofuranone on hydrogen peroxide-induced damage in PC12 cells.
Topics: Animals; Apoptosis; Benzofurans; Calcium; Cell Survival; Drug Interactions; Glutathione Peroxidase; Hydrogen Peroxide; L-Lactate Dehydrogenase; Malondialdehyde; Membrane Potential, Mitochondrial; Neuroprotective Agents; Oxidants; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species | 2010 |
DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway.
Topics: Animals; Apoptosis; Benzofurans; Blotting, Western; Brain Ischemia; Caspase 3; Caspase 9; Enzyme Activation; Fluorescent Antibody Technique; In Situ Nick-End Labeling; Male; MAP Kinase Kinase 4; Mice; Neurons; Neuroprotective Agents; Signal Transduction | 2010 |
[Butylphthalide improves learning and memory abilities of rats with Alzheimer's disease possibly by enhancing protein disulfide isomerase and inhibiting P53 expressions].
Topics: Alzheimer Disease; Animals; Apoptosis; Benzofurans; Brain; Disease Models, Animal; Learning; Male; Memory; Protein Disulfide-Isomerases; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2010 |
L-3-n-butylphthalide regulates amyloid precursor protein processing by PKC and MAPK pathways in SK-N-SH cells over-expressing wild type human APP695.
Topics: Amyloid beta-Protein Precursor; Benzofurans; Cell Line, Tumor; Cell Survival; Drugs, Chinese Herbal; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Kinase C; Protein Processing, Post-Translational; Seeds | 2011 |
L-3-n-butyl-phthalide alleviates hydrogen peroxide-induced apoptosis by PKC pathway in human neuroblastoma SK-N-SH cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Benzofurans; Cell Line, Tumor; Cell Survival; Gene Expression; Humans; Hydrogen Peroxide; Naphthalenes; Neuroblastoma; Neuroprotective Agents; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2011 |
An efficient system for the asymmetric acylation of (R,S)-3-n-butylphthalide catalyzed by novozyme 435.
Topics: Acylation; Benzofurans; Candida; Catalysis; Enzymes, Immobilized; Fungal Proteins; Furans; Lipase; Water | 2010 |
[Effects of butylphthalide on the apoptosis of PC-12 cells under the induction of β-amyloid peptide].
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; PC12 Cells; Peptide Fragments; Rats | 2010 |
[Simultaneous determination of five effective components in Rhizoma Chuanxiong by RP-HPLC].
Topics: 4-Butyrolactone; Benzofurans; Calibration; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Pyrazines | 2010 |
Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1.
Topics: Animals; Benzofurans; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Membrane Potentials; Neuroprotective Agents; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Rats; Stereoisomerism | 2011 |
Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease.
Topics: Animals; Antioxidants; Antiparkinson Agents; Benzofurans; Cell Line; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Humans; Neuroprotective Agents; Parkinsonian Disorders; Rats; Rotenone; Treatment Outcome | 2012 |
3-n-Butylphthalide (NBP) attenuated neuronal autophagy and amyloid-β expression in diabetic mice subjected to brain ischemia.
Topics: Amyloid beta-Peptides; Animals; Autophagy; Benzofurans; Brain Ischemia; Dementia; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Random Allocation; Treatment Outcome | 2011 |
Synthesis and evaluation of nitric oxide-releasing derivatives of 3-n-butylphthalide as anti-platelet agents.
Topics: Adenosine Diphosphate; Animals; Benzoates; Benzofurans; Blood Platelets; Caffeic Acids; Nitrates; Nitric Oxide; Platelet Aggregation Inhibitors; Rabbits | 2011 |
Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents.
Topics: Animals; Benzofurans; Blood Platelets; Drug Synergism; Fibrinolytic Agents; Male; Mice; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis | 2011 |
Asymmetric synthesis and sensory evaluation of sedanenolide.
Topics: Alkynes; Apium; Benzofurans; Cyclization; Food Additives; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Odorants; Propanols; Sensory Thresholds; Stereoisomerism; Taste; Taste Perception | 2011 |
[Studies on the chemical constituents of Ligusticum sinense].
Topics: Aldehydes; Benzofurans; Ligusticum; Mass Spectrometry; Molecular Structure; Plant Extracts; Plants, Medicinal; Rhizome | 2011 |
DL-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Benzofurans; Disease Models, Animal; Mice; Mice, Transgenic; Motor Neurons; Neuroglia; Neuroprotective Agents; Spinal Cord; Superoxide Dismutase | 2012 |
(S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death.
Topics: Animals; Benzofurans; Cell Death; Cinnamates; Disease Models, Animal; Hypoxia-Ischemia, Brain; Male; Mitochondrial Diseases; Nerve Degeneration; Neuroprotective Agents; Nitrates; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2012 |
L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzofurans; Brain; Cell Line, Tumor; Cognition Disorders; Cyclin-Dependent Kinase 5; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Maze Learning; Mice; Mice, Transgenic; Neuroblastoma; Neuroprotective Agents; Phosphorylation; Presenilin-1; Reaction Time; Spatial Behavior; tau Proteins; Time Factors | 2012 |
Effects of DL-3-n-butylphthalide on vascular dementia and angiogenesis.
Topics: Animals; Benzofurans; Cell Line, Tumor; Chick Embryo; Dementia, Vascular; Drugs, Chinese Herbal; Humans; Immunohistochemistry; Male; Maze Learning; Neovascularization, Physiologic; Neuroprotective Agents; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2012 |
dl-3n-Butylphthalide promotes angiogenesis via the extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase/Akt-endothelial nitric oxide synthase signaling pathways.
Topics: Animals; Benzofurans; Dose-Response Relationship, Drug; Human Umbilical Vein Endothelial Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Physiologic; Neuroprotective Agents; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Zebrafish | 2012 |
L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.
Topics: Animals; Benzofurans; Brain Ischemia; Chronic Disease; Cognition Disorders; Male; Maze Learning; Neuroprotective Agents; Random Allocation; Rats; Rats, Wistar | 2012 |
Protection against neurotoxicity by an autophagic mechanism.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apium; Autophagy; Benzofurans; Blotting, Western; Cell Survival; Immunohistochemistry; Microscopy, Electron, Transmission; Neuroprotective Agents; Parkinson Disease, Secondary; PC12 Cells; Rats; Seeds | 2012 |
[Effect of butylphthalide on levels of glutamate and expression of NR2B in the hippocampus of rats with alcohol addiction].
Topics: Alcohol-Related Disorders; Animals; Benzofurans; Glutamic Acid; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2012 |
DL-3-n-Butylphthalide protects rat bone marrow stem cells against hydrogen peroxide-induced cell death through antioxidation and activation of PI3K-Akt pathway.
Topics: Animals; Antioxidants; Apoptosis; Benzofurans; Bone Marrow Cells; Enzyme Activation; Hematopoietic Stem Cells; Hydrogen Peroxide; Oxidants; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2012 |
DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment.
Topics: Analysis of Variance; Animals; Antioxidants; Benzofurans; Brain Infarction; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Nervous System Diseases; Neurologic Examination; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazolium Salts | 2012 |
Therapeutic effects of dl-3-n-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Benzofurans; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Transgenic | 2012 |
The therapeutic effect of (DL)-3-n-butylphthalide in rats with chronic cerebral hypoperfusion through downregulation of amyloid precursor protein and matrix metalloproteinase-2.
Topics: Amyloid beta-Protein Precursor; Animals; Benzofurans; Blotting, Western; Brain Ischemia; Chronic Disease; Down-Regulation; Immunohistochemistry; Male; Matrix Metalloproteinase 2; Maze Learning; Rats; Rats, Wistar | 2012 |
Dl-3-n-butylphthalide and its emerging beneficial effects in neurology.
Topics: Benzofurans; Humans; Neuroprotective Agents; Oxidative Stress | 2012 |
An increased TREK-1-like potassium current in ventricular myocytes during rat cardiac hypertrophy.
Topics: Animals; Benzofurans; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Gene Expression Regulation; Heart Ventricles; Hypertrophy, Left Ventricular; Isoproterenol; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley | 2013 |
Simultaneous quantitation of 3-n-butylphthalide (NBP) and its four major metabolites in human plasma by LC-MS/MS using deuterated internal standards.
Topics: Benzofurans; Chromatography, Liquid; Deuterium; Humans; Reference Standards; Tandem Mass Spectrometry | 2013 |
Novel hybrids of optically active ring-opened 3-n-butylphthalide derivative and isosorbide as potential anti-ischemic stroke agents.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Isosorbide; Platelet Aggregation Inhibitors; Rats; Stereoisomerism; Stroke | 2013 |
Antihypertensive effect of celery seed on rat blood pressure in chronic administration.
Topics: Animals; Antihypertensive Agents; Apium; Benzofurans; Blood Pressure; Heart Rate; Humans; Hypertension; Male; Plant Extracts; Rats; Rats, Wistar; Seeds | 2013 |
Pharmacokinetics in Sprague-Dawley rats and Beagle dogs and in vitro metabolism of ZJM-289, a novel nitric dioxide donor.
Topics: Administration, Intravenous; Animals; Benzofurans; Chromatography, Liquid; Cinnamates; Dogs; Drug Discovery; Molecular Structure; Nitrates; Nitric Oxide; Prodrugs; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2014 |
Combined edaravone and D1-3-n-butylphthalide antioxidant therapy for paraquat poisoning.
Topics: Adult; Antioxidants; Antipyrine; Benzofurans; Drug Therapy, Combination; Edaravone; Emergency Service, Hospital; Humans; Male; Paraquat | 2014 |
3-N-butylphthalide (NBP) attenuates the amyloid-β-induced inflammatory responses in cultured astrocytes via the nuclear factor-κB signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzofurans; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; I-kappa B Proteins; Interleukin-6; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neuroprotective Agents; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Treatment for acute ischemic stroke: new evidence from China.
Topics: Benzofurans; China; Fibrinolytic Agents; Humans; Stroke | 2013 |
Enantioselective determination of 3-n-butylphthalide (NBP) in human plasma by liquid chromatography on a teicoplanin-based chiral column coupled with tandem mass spectrometry.
Topics: Benzofurans; Chromatography, Liquid; Drug Stability; Humans; Least-Squares Analysis; Male; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tandem Mass Spectrometry; Teicoplanin | 2013 |
L-3-n-Butylphthalide protects rats' cardiomyocytes from ischaemia/reperfusion-induced apoptosis by affecting the mitochondrial apoptosis pathway.
Topics: Animals; Antioxidants; Apoptosis; Benzofurans; Blotting, Western; In Situ Nick-End Labeling; Male; Mitochondria; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2014 |
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; Benzofurans; Brain Ischemia; Cell Survival; Mice; Neuroblastoma; Sirolimus; Stroke; Tumor Cells, Cultured | 2014 |
The effect of butylphthalide on the brain edema, blood-brain barrier of rats after focal cerebral infarction and the expression of Rho A.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain; Brain Edema; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Immunohistochemistry; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Time Factors; Water | 2014 |
Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1.
Topics: Acetylcysteine; Animals; Arylsulfotransferase; Benzofurans; Biotransformation; Cell Survival; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Glutathione; Hepatocytes; Humans; Hydroxylation; Kidney; Liver; Male; Microsomes, Liver; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sulfur Compounds | 2014 |
Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide.
Topics: Aging; Animals; Benzofurans; Cerebral Cortex; Choline O-Acetyltransferase; Cognition; Hippocampus; Male; Maze Learning; Mice; Prosencephalon; Septal Nuclei | 2014 |
Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Benzofurans; Drug Design; Fibrinolytic Agents; Hydrogen Sulfide; Inhibitory Concentration 50; Male; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats, Sprague-Dawley; Survival Analysis | 2014 |
Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure.
Topics: Animals; Apoptosis; Benzofurans; Brain-Derived Neurotrophic Factor; Drug Evaluation, Preclinical; Hypercapnia; Hypoxia, Brain; Male; Maze Learning; Memory; Mitochondrial Turnover; Neuroprotective Agents; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Sirtuin 1; Transcription Factors | 2014 |
Effects of L-3-n-butylphthalide on cognitive dysfunction and NR2B expression in hippocampus of streptozotocin (STZ)-induced diabetic rats.
Topics: Animals; Benzofurans; Blood Glucose; Body Weight; Cognition; Diabetes Mellitus, Experimental; Gene Expression Regulation; Hippocampus; Male; Maze Learning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2015 |
l-3-n-Butylphthalide attenuates β-amyloid-induced toxicity in neuroblastoma SH-SY5Y cells through regulating mitochondrion-mediated apoptosis and MAPK signaling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; Caspase 3; Caspase 9; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Neuroblastoma; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Reactive Oxygen Species; Signal Transduction | 2014 |
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats.
Topics: Albumins; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Urea Nitrogen; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Hypertension, Renal; Immunohistochemistry; Interleukin-6; Kidney Glomerulus; Losartan; Male; NADPH Oxidases; Nephritis; Neuroprotective Agents; NF-kappa B; Rats; Rats, Inbred SHR; Transforming Growth Factor beta1 | 2015 |
Quantification of 3-n-butylphthalide in beagle plasma samples by supercritical fluid chromatography with triple quadruple mass spectrometry and its application to an oral bioavailability study.
Topics: Animals; Benzofurans; Biological Availability; Chromatography, Supercritical Fluid; Dogs; Drugs, Chinese Herbal; Male; Mass Spectrometry | 2015 |
DL-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2 synthesis and phosphodiesterase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium; Collagen; Cyclic AMP; Humans; Phospholipases A2, Cytosolic; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2 | 2015 |
Effects of N-Butylphthalide on the expressions of Nogo/NgR in rat brain tissue after carbon monoxide poisoning.
Topics: Animals; Apoptosis; Benzofurans; Brain; Carbon Monoxide Poisoning; GPI-Linked Proteins; Male; Myelin Proteins; Myelin-Associated Glycoprotein; Neuroprotective Agents; Nogo Proteins; Nogo Receptor 1; Rats, Sprague-Dawley; Receptors, Cell Surface | 2015 |
Synthesis, recognition characteristics and properties of l-3-n-butylphthalide molecularly imprinted polymers as sorbent for solid-phase extraction through precipitation polymerization.
Topics: Adsorption; Benzofurans; Chemical Precipitation; Molecular Imprinting; Polymerization; Solid Phase Extraction | 2015 |
Effects of N-butylphthalide on the activation of Keap1/Nrf-2 signal pathway in rats after carbon monoxide poisoning.
Topics: Animals; Apoptosis; Benzofurans; Brain; Carbon Monoxide Poisoning; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Membrane Potential, Mitochondrial; NF-E2-Related Factor 2; Rats; Signal Transduction | 2015 |
The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats.
Topics: Animals; Antioxidants; Antipyrine; Apoptosis; Benzofurans; Brain; Edaravone; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-kappa B; Rats, Sprague-Dawley; Signal Transduction; Water | 2015 |
Dl-3-n-butylphthalide is effective for demyelination: a case-combined study.
Topics: Adult; Animals; Benzofurans; Brain; Demyelinating Diseases; Disease Models, Animal; Electroencephalography; Humans; Magnetic Resonance Imaging; Male; Methylprednisolone; Radiography; Rats, Sprague-Dawley; Treatment Outcome | 2015 |
Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Antipyrine; Behavior, Animal; Benzofurans; Biological Availability; Brain; Carrageenan; Cell Line; Disease Models, Animal; Edaravone; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Isoindoles; Male; Mice; Molecular Structure; Neuroprotective Agents; Oxidative Stress; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Structure-Activity Relationship; Thrombosis; Tissue Distribution | 2015 |
Novel hybrids of 3-n-butylphthalide and edaravone: Design, synthesis and evaluations as potential anti-ischemic stroke agents.
Topics: Animals; Antipyrine; Benzofurans; Cell Line; Drug Design; Edaravone; Free Radical Scavengers; Humans; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Stroke | 2015 |
L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats.
Topics: Administration, Oral; Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Survival; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Hippocampus; Infarction, Middle Cerebral Artery; Male; Neural Stem Cells; Neurogenesis; Neuronal Plasticity; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Recovery of Function; STAT3 Transcription Factor; Synapses | 2015 |
[Interaction of butylphthalide with rat and human liver CYP450 isoenzymes].
Topics: Animals; Benzofurans; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Liver; Microsomes, Liver; Rats | 2015 |
[Effect of 3-n-butylphthalide pretreatment on expression of the HSP70 after brain ischemia/reperfusion].
Topics: Animals; Benzofurans; CA1 Region, Hippocampal; Cell Death; Cerebral Infarction; HSP70 Heat-Shock Proteins; Ischemic Preconditioning; Neurons; Rats; Rats, Wistar; Reperfusion Injury | 2015 |
Titanium superoxide--a stable recyclable heterogeneous catalyst for oxidative esterification of aldehydes with alkylarenes or alcohols using TBHP as an oxidant.
Topics: Alcohols; Aldehydes; Anticonvulsants; Benzofurans; Benzyl Compounds; Esterification; Oxidants; Oxidation-Reduction; Peroxides; Superoxides; Titanium | 2015 |
Isomer-selective distribution of 3-n-butylphthalide (NBP) hydroxylated metabolites, 3-hydroxy-NBP and 10-hydroxy-NBP, across the rat blood-brain barrier.
Topics: Administration, Oral; Animals; Benzofurans; Biological Transport; Blood-Brain Barrier; Drugs, Chinese Herbal; Isomerism; Male; Rats; Rats, Sprague-Dawley | 2015 |
Cytotoxic Activities, SAR and Anti-Invasion Effects of Butylphthalide Derivatives on Human Hepatocellular Carcinoma SMMC7721 Cells.
Topics: Antineoplastic Agents; Benzofurans; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Liver Neoplasms; Molecular Structure; Plant Extracts | 2015 |
L-3-n-Butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and upregulating Heme oxygenase-1 in lipopolysaccharide-treated mice.
Topics: Animals; Benzofurans; Brain; Cytokines; Disease Models, Animal; Heme Oxygenase-1; Immunologic Factors; Inflammation; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinases; Molecular Structure; Neuroprotective Agents; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 2016 |
DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model.
Topics: Animals; Benzofurans; Biomarkers; Blood Glucose; Body Weight; Catalase; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Progression; Immunohistochemistry; Lens, Crystalline; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats; Thioredoxins | 2016 |
Impacts of N-Butylphthalide on expression of growth factors in rats with focal cerebral ischemia.
Topics: Animals; Behavior, Animal; Benzofurans; Brain Ischemia; Cerebral Infarction; Intercellular Signaling Peptides and Proteins; Male; Neurologic Examination; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Messenger; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2016 |
Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients.
Topics: Aged; Antigens, CD; Benzofurans; Brain Ischemia; Cell Movement; Diffusion Magnetic Resonance Imaging; Endothelial Progenitor Cells; Female; Follow-Up Studies; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Retrospective Studies; Severity of Illness Index; Statistics as Topic; Stroke; Time Factors; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer's disease mouse model.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Brain; Cognition; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; NF-E2-Related Factor 2; Oxidative Stress; Up-Regulation | 2016 |
dl-3-n-butylphthalide suppresses PDGF-BB-stimulated vascular smooth muscle cells proliferation via induction of autophagy.
Topics: Animals; Autophagosomes; Autophagy; Becaplermin; Benzofurans; beta Catenin; Cell Cycle; Cell Proliferation; Cells, Cultured; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Proto-Oncogene Proteins c-sis; Rats; Triazoles | 2016 |
The effect of butylphthalide on aminoacid content in the brain of epileptic mice.
Topics: Amino Acids; Animals; Benzofurans; Brain; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Mice | 2022 |
Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Caspase 3; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Neurons; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction | 2016 |
Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent.
Topics: Animals; Antioxidants; Benzofurans; Drug Discovery; Male; Rats; Stroke | 2016 |
5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury.
Topics: Animals; Benzofurans; Brain; Casein Kinase II; Cell Membrane; Cell Survival; Cytosol; Gene Expression Regulation, Enzymologic; Infarction, Middle Cerebral Artery; Male; NADPH Oxidases; Neurons; Neuroprotective Agents; Oxidative Stress; rac1 GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; RNA Interference | 2016 |
Assessment of Angelica sinensis (Oliv.) Diels as a repellent for personal protection against mosquitoes under laboratory and field conditions in northern Thailand.
Topics: Angelica sinensis; Animals; Benzofurans; Culicidae; Female; Humans; Insect Repellents; Linoleic Acid; Male; Molecular Structure; Phthalic Anhydrides; Plant Extracts; Thailand | 2016 |
Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest.
Topics: Animals; Arachidonic Acid; Benzofurans; Blotting, Western; Cell Proliferation; Chloroform; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Etomidate; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; Humans; Membrane Potentials; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Potassium Channels, Tandem Pore Domain; Signal Transduction; Transfection | 2016 |
L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; beta Catenin; Dendritic Spines; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neuroprotective Agents; Presenilin-1; Synapses | 2016 |
N-Butylphthalide (NBP) ameliorated cerebral ischemia reperfusion-induced brain injury via HGF-regulated TLR4/NF-κB signaling pathway.
Topics: Animals; Astrocytes; Benzofurans; Brain Ischemia; Cell Survival; Hepatocyte Growth Factor; Humans; Inflammation; Lipopolysaccharides; Male; NF-kappa B; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Up-Regulation | 2016 |
Protective Effect of Dl-3-n-Butylphthalide on Recovery from Cardiac Arrest and Resuscitation in Rats.
Topics: Animals; Benzofurans; CA1 Region, Hippocampal; Disease Models, Animal; Heart Arrest; Male; Neurons; Neuroprotective Agents; Rats, Wistar; Recovery of Function; Resuscitation; Time Factors | 2016 |
dl-3-n-Butylphthalide attenuation of methamphetamine-induced neurotoxicity in SH-SY5Y neuroblastoma cells.
Topics: Benzofurans; Cell Line, Tumor; Humans; Methamphetamine; Neuroblastoma; Neurotoxicity Syndromes; Reactive Oxygen Species; Signal Transduction | 2016 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
Topics: Benzofurans; Biomarkers; Brain Ischemia; C-Reactive Protein; Cognition; Dementia, Vascular; Female; Homocysteine; Humans; Logistic Models; Male; Mental Status Schedule; Middle Aged; Multivariate Analysis; Neuroprotective Agents; Neuropsychological Tests; Nootropic Agents; Prospective Studies; Risk Factors; Stroke; Treatment Outcome | 2017 |
DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway.
Topics: Animals; Benzofurans; Brain Injuries, Traumatic; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Random Allocation; Signal Transduction | 2017 |
Synthesis and biological evaluation of nitric oxide (NO)-hydrogen sulfide (H
Topics: Animals; Benzofurans; Humans; Hydrogen Sulfide; Male; Molecular Structure; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Thrombosis | 2016 |
Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study.
Topics: Adrenal Cortex Hormones; Adult; Benzofurans; Brain Injuries; Cranial Irradiation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Outcome Assessment, Health Care; Radiation Injuries; Retrospective Studies | 2017 |
DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice.
Topics: Animals; Behavior, Animal; Benzofurans; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Interleukin-1beta; Male; Mice, Inbred C57BL; Neuroprotection; NF-kappa B; Recovery of Function; Signal Transduction; Up-Regulation | 2017 |
Toxicokinetics and toxicity of potassium 2-(1-hydroxypentyl)-benzoate in beagle dogs.
Topics: Animals; Benzoates; Benzofurans; China; Dogs; Female; Humans; Male; Molecular Structure; Pentanes; Potassium; Toxicokinetics | 2017 |
dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats.
Topics: Animals; Benzofurans; Biotin; Brain Infarction; Dextrans; Disease Models, Animal; Disks Large Homolog 4 Protein; Doublecortin Protein; Endothelin-1; Male; Motor Activity; Neuronal Plasticity; Nogo Proteins; Nogo Receptor 1; Platelet Aggregation Inhibitors; Psychomotor Performance; Rats; Rats, Wistar; Recovery of Function; Signal Transduction; Stroke; Vesicular Glutamate Transport Protein 1 | 2017 |
Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis.
Topics: Animals; Benzofurans; Cardiotonic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Heart; Membrane Potential, Mitochondrial; Mitochondria; Myoblasts, Cardiac; Myocardial Infarction; Neuroprotective Agents; Organelle Biogenesis; Oxidative Stress; Rats | 2017 |
L-3-n-Butylphthalide Activates Akt/mTOR Signaling, Inhibits Neuronal Apoptosis and Autophagy and Improves Cognitive Impairment in Mice with Repeated Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; Brain Ischemia; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Male; Memory Disorders; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Reperfusion; TOR Serine-Threonine Kinases | 2017 |
Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-κB signalling.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Cell Line; Coculture Techniques; Female; Gene Expression Regulation; Lipopolysaccharides; Microglia; Neuroprotective Agents; NF-kappa B; PC12 Cells; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Toll-Like Receptor 4 | 2017 |
Protective effects of DL‑3‑n‑butylphthalide in the lipopolysaccharide‑induced mouse model of Parkinson's disease.
Topics: Animals; Apoptosis; Benzofurans; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Rotarod Performance Test; Substantia Nigra; Tyrosine 3-Monooxygenase | 2017 |
Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs.
Topics: Adipose Tissue; Animals; Aryldialkylphosphatase; Benzoates; Benzofurans; Brain; Dogs; Feces; Female; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Pentanes; Prodrugs; Rats, Sprague-Dawley | 2018 |
Effect of hippocampal L‑NBP on BDNF and TrkB expression and neurological function of vascular dementia rats.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Carotid Artery, Common; Cerebral Cortex; Dementia, Vascular; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Ligation; Male; Maze Learning; Memory, Short-Term; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
Effects of butylphthalide on cognitive decline in diabetic rats.
Topics: Animals; Benzofurans; Blood Glucose; Body Weight; Brain-Derived Neurotrophic Factor; Cognition; Cognitive Dysfunction; Cytokines; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Gene Expression Regulation; Hippocampus; Inflammation Mediators; Maze Learning; Neuroprotective Agents; Rats | 2017 |
Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Brain Ischemia; Citric Acid; Disease Models, Animal; Glucose; Infarction; Metabolic Networks and Pathways; Neuroprotective Agents; Platelet Aggregation Inhibitors; Rats; Severity of Illness Index; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2017 |
DL-3-n-butylphthalide alleviates vascular cognitive impairment induced by chronic cerebral hypoperfusion by activating the Akt/Nrf2 signaling pathway in the hippocampus of rats.
Topics: Animals; Benzofurans; Brain Ischemia; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
The protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats.
Topics: Animals; Apoptosis; Benzofurans; Blood-Brain Barrier; Body Water; Brain Ischemia; Caspase 3; Hippocampus; Infarction, Middle Cerebral Artery; Malondialdehyde; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase | 2017 |
Dl-3-n-butylphthalide prevents the disruption of blood-spinal cord barrier via inhibiting endoplasmic reticulum stress following spinal cord injury.
Topics: Adherens Junctions; Animals; Benzofurans; Blood-Brain Barrier; Cells, Cultured; Endoplasmic Reticulum Stress; Female; Humans; Locomotion; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Tight Junctions | 2017 |
DL‑3‑n‑butylphthalide reduces microglial activation in lipopolysaccharide‑induced Parkinson's disease model mice.
Topics: alpha-Synuclein; Animals; Benzofurans; Disease Models, Animal; Dyskinesias; Gene Expression Regulation; Immunohistochemistry; Lipopolysaccharides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; Neuroprotective Agents; Parkinson Disease, Secondary; Rotarod Performance Test; Substantia Nigra; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2018 |
DL-3-n-Butylphthalide reduces atrial fibrillation susceptibility by inhibiting atrial structural remodeling in rats with heart failure.
Topics: Animals; Atrial Remodeling; Benzofurans; Cardiotonic Agents; Heart Atria; Heart Diseases; Heme Oxygenase (Decyclizing); Male; NF-E2-Related Factor 2; NF-kappa B; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2018 |
Butylphthalide ameliorates experimental autoimmune encephalomyelitis by suppressing PGAM5-induced necroptosis and inflammation in microglia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Benzofurans; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Necrosis; Neuroprotective Agents; Phosphoprotein Phosphatases; Treatment Outcome | 2018 |
DL-3-n-butylphthalide improves ventricular function, and prevents ventricular remodeling and arrhythmias in post-MI rats.
Topics: Animals; Arrhythmias, Cardiac; Benzofurans; Cardiotonic Agents; Connexin 43; Fibrosis; Heart Ventricles; Myocardial Infarction; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Ventricular Function; Ventricular Remodeling | 2018 |
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antioxidants; Apoptosis; Benzofurans; Carrier Proteins; Cell Line, Tumor; HEK293 Cells; Humans; Inflammasomes; Interleukin-1beta; Male; Mice; Mice, Transgenic; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Binding; Thioredoxins | 2019 |
Dl-3-n-butylphthalide protects the blood brain barrier of cerebral infarction by activating the Nrf-2/HO-1 signaling pathway in mice.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain; Cerebral Infarction; Heme Oxygenase-1; Male; Membrane Proteins; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Rats, Sprague-Dawley; Signal Transduction | 2018 |
DL-3-n-butylphthalide promotes dendrite development in cortical neurons subjected to oxygen-glucose deprivation/reperfusion.
Topics: Animals; Apoptosis; Benzofurans; Cell Hypoxia; Cells, Cultured; Chromones; Dendrites; Glucose; Morpholines; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cell Differentiation; Cell Movement; Cell Proliferation; Embryo, Mammalian; Humans; Intercellular Signaling Peptides and Proteins; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; Presenilin-1 | 2018 |
Dl-3-N-butylphthalide attenuates ischemic reperfusion injury by improving the function of cerebral artery and circulation.
Topics: Animals; Benzofurans; Cerebral Arteries; Cerebrovascular Circulation; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; Platelet Aggregation Inhibitors; Rats, Sprague-Dawley; Reperfusion Injury; Vasodilator Agents | 2019 |
[Effects of N-butylphthalide on the expressions of ZO-1 and claudin-5 in blood-brain barrier of rats with acute carbon monoxide poisoning].
Topics: Animals; Benzofurans; Blood-Brain Barrier; Carbon Monoxide Poisoning; Claudin-5; Male; Rats; Rats, Sprague-Dawley | 2018 |
[Effects of butylphthalide on bronchial asthma in guinea pigs and involvement of endothelin].
Topics: Animals; Asthma; Benzofurans; Bronchoalveolar Lavage Fluid; Endothelin-1; Guinea Pigs; Ovalbumin | 2016 |
[Preliminary pharmacodynamics study on antiasthmatic action of butylphthalide in guinea pig].
Topics: Animals; Anti-Asthmatic Agents; Asthma; Benzofurans; Endothelin-1; Guinea Pigs; Muscle, Smooth; Nitric Oxide; Trachea | 2017 |
Dl-3-n-Butylphthalide improves lipopolysaccharide-induced depressive-like behavior in rats: involvement of Nrf2 and NF-κB pathways.
Topics: Animals; Antioxidants; Benzofurans; Cytokines; Depression; Lipopolysaccharides; Male; Neuroprotective Agents; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction | 2018 |
Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Carrier Proteins; Disease Models, Animal; Female; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred ICR; Neuroprotective Agents; Phosphorylation; Reperfusion Injury; Signal Transduction | 2018 |
L-butyl phthalein improves neural function of vascular dementia mice by regulating the PI3K/AKT signaling pathway.
Topics: Animals; Apoptosis; Benzofurans; Dementia, Vascular; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction | 2018 |
Neuroprotective Effects of dl-3-n-Butylphthalide against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes.
Topics: Antibiotics, Antineoplastic; Behavioral Symptoms; Benzofurans; Doxorubicin; Endoplasmic Reticulum Stress; Humans; Inflammation; Neuroprotective Agents; Oxidative Stress | 2018 |
A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities.
Topics: Administration, Oral; Animals; Benzofurans; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Liquid-Liquid Extraction; Male; Metoprolol; Midazolam; Omeprazole; Phenacetin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2019 |
L-3-n-butylphthalide attenuates cognitive deficits in db/db diabetic mice.
Topics: Animals; Benzofurans; Caspase 3; Cognition; Cognitive Dysfunction; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Hippocampus; Maze Learning; Mice; Neuroprotective Agents; Oxidative Stress | 2019 |
3-
Topics: Animals; Antioxidants; Apoptosis; Benzofurans; Brain Ischemia; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Dynamics; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Signal Transduction; Stroke | 2018 |
Bioactive butylphthalide derivatives from Ligusticum chuanxiong.
Topics: Benzofurans; Cell Line, Tumor; Cell Survival; Circular Dichroism; Humans; Ligusticum; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Roots; Protective Agents; Stereoisomerism | 2019 |
L-NBP, a multiple growth factor activator, attenuates ischemic neuronal impairments possibly through promoting neuritogenesis.
Topics: Animals; Benzofurans; Cell Hypoxia; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Rats, Sprague-Dawley | 2019 |
dl-3-n-butylphthalide for alleviation of neurological deficit after combined extracranial-intracranial revascularization for moyamoya disease: a propensity score-matched analysis.
Topics: Adult; Benzofurans; Cerebral Revascularization; Cohort Studies; Combined Modality Therapy; Female; Humans; Male; Middle Aged; Moyamoya Disease; Nervous System Diseases; Neuroprotective Agents; Pilot Projects; Postoperative Complications; Propensity Score; Prospective Studies | 2019 |
[Effects of butylphthalide on plasma nitric oxide and endothelin-1 in severe elderly OSAHS patients].
Topics: Aged; Benzofurans; Continuous Positive Airway Pressure; Endothelin-1; Humans; Neuroprotective Agents; Nitric Oxide; Sleep Apnea, Obstructive | 2019 |
Dl-3-n-Butylphthalide regulates the Ang-1/Ang-2/Tie-2 signaling axis to promote neovascularization in chronic cerebral hypoperfusion.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Benzofurans; Blotting, Western; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Male; Neovascularization, Physiologic; Protein Array Analysis; Rats; Rats, Sprague-Dawley; Receptor, TIE-2; Signal Transduction | 2019 |
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cells, Cultured; Claudin-5; Immunohistochemistry; Male; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Tight Junction Proteins; Zonula Occludens-1 Protein | 2019 |
Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.
Topics: Animals; Benzofurans; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Differentiation; Male; Myelin Sheath; Nogo Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Rats; Rats, Wistar; Recovery of Function; Remyelination; Stroke; White Matter | 2019 |
Multiple functional therapeutic effects of DL-3-n-butylphthalide in the cuprizone model of demyelination.
Topics: Animals; Astrocytes; Axons; Benzofurans; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Myelin Sheath; Neuroprotective Agents; NF-kappa B; Oligodendroglia; Signal Transduction | 2019 |
3-n-butylphthalide inhibits the apoptosis of nerve cells in rats with cerebral small vessel disease via the PI3K/Akt pathway.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Benzofurans; Brain Chemistry; Carotid Artery Diseases; Caspase 3; Cerebral Small Vessel Diseases; Male; Maze Learning; Neurons; Neuroprotective Agents; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
dl-3n-butylphthalide reduces oxygen-glucose deprivation-induced endothelial cell damage by increasing PGC-1α.
Topics: Benzofurans; Cell Hypoxia; Cell Line; Cell Shape; Cell Survival; Endothelial Cells; Enzyme Inhibitors; Glucose; Humans; Neuroprotective Agents; Nitric Oxide Synthase Type III; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | 2019 |
DL-3-n-butylphthalide attenuates lipopolysaccharide-induced acute lung injury via SIRT1-dependent and -independent regulation of Nrf2.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Benzofurans; Bronchoalveolar Lavage Fluid; Cytokines; Lipopolysaccharides; Lung; Male; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Pulmonary Edema; Sirtuin 1 | 2019 |
DL-3-n-butylphthalide Protected Retinal Müller Cells Dysfunction from Oxidative Stress.
Topics: Apoptosis; Benzofurans; Blotting, Western; Cell Line; Cell Survival; Endoplasmic Reticulum; Ependymoglial Cells; Fluoresceins; Fluorescent Antibody Technique; Heme Oxygenase-1; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Reactive Oxygen Species; Retinal Diseases; Signal Transduction | 2019 |
Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
Dl-3-N-Butylphthalide Alleviates the Blood-Brain Barrier Permeability of Focal Cerebral Ischemia Reperfusion in Mice.
Topics: Animals; Benzofurans; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillary Permeability; Caveolin 1; Cerebrovascular Circulation; Disease Models, Animal; Male; Mice; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Tight Junctions | 2019 |
dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion.
Topics: Animals; Benzofurans; Brain Ischemia; Carotid Stenosis; Cells, Cultured; Cerebrovascular Circulation; Chronic Disease; Cognitive Dysfunction; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; White Matter | 2019 |
Potentiation of spinal cord conduction and neuroprotection following nanodelivery of DL-3-n-butylphthalide in titanium implanted nanomaterial in a focal spinal cord injury induced functional outcome, blood-spinal cord barrier breakdown and edema formation
Topics: Animals; Benzofurans; Capillary Permeability; Drug Delivery Systems; Drug Implants; Edema; Evoked Potentials; Locomotion; Male; Nanostructures; Nanowires; Neuroprotective Agents; Rats; Spinal Cord Injuries; Titanium | 2019 |
3-N-butylphthalide inhibits neuronal apoptosis in rats with cerebral infarction via targeting P38/MAPK.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Benzofurans; Cerebral Infarction; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation; Injections, Intraperitoneal; MAP Kinase Signaling System; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats | 2019 |
Butylphthalide ameliorates airway inflammation and mucus hypersecretion via NF-κB in a murine asthma model.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Benzofurans; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Leukocyte Count; Lung; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Ovalbumin | 2019 |
Dl-3-n-butylphthalide inhibits phenytoin-induced neuronal apoptosis in rat hippocampus and cerebellum.
Topics: Animals; Anticonvulsants; Apoptosis; Benzofurans; Cerebellum; Hippocampus; Male; Neurons; Neuroprotective Agents; Phenytoin; Rats; Rats, Sprague-Dawley | 2019 |
Effects of butylphthalide on oxidative stress and inflammatory response in rats with myocardial infarction through Akt/Nrf2 signaling pathway.
Topics: Animals; Benzofurans; Disease Models, Animal; Inflammation; Male; Myocardial Infarction; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Dl-3n-butylphthalide improves traumatic brain injury recovery via inhibiting autophagy-induced blood-brain barrier disruption and cell apoptosis.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; Blood-Brain Barrier; Brain Injuries, Traumatic; Cells, Cultured; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Recovery of Function | 2020 |
[Effect of butylphthalide on blood-brain barrier after cerebral hemorrhage in SD rats and the mechanisms].
Topics: Animals; Benzofurans; Blood-Brain Barrier; Cerebral Hemorrhage; Endothelial Cells; Rats; Rats, Sprague-Dawley | 2019 |
Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway.
Topics: Animals; Benzofurans; Cyclic AMP Response Element-Binding Protein; Depressive Disorder, Major; Energy Metabolism; Mice; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; Signal Transduction; Social Defeat | 2020 |
Vision treatment strategy for acute blindness in adolescent female with diffuse leptomeningeal glioneuronal tumor.
Topics: Adolescent; Benzofurans; Blindness; Cerebrospinal Fluid Shunts; Female; Humans; Meningeal Neoplasms; Neuroprotective Agents | 2020 |
Influence of butyphthalide combined with urinary kallikrein in ACI treatment on neuro-cytokines and vascular endothelial function and its clinical effect.
Topics: Adult; Aged; Benzofurans; Cerebral Infarction; Cytokines; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Kallikreins; Male; Middle Aged; Phosphopyruvate Hydratase; Treatment Outcome | 2021 |
Butylphthalide has an Anti-Inflammatory Role in Spinal Cord Injury by Promoting Macrophage/Microglia M2 Polarization via p38 Phosphorylation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Benzofurans; Cell Polarity; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Spinal Cord Injuries; Thoracic Vertebrae | 2020 |
The Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy After Acute Carbon Monoxide Poisoning.
Topics: Activities of Daily Living; Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Benzofurans; Brain Diseases; Carbon Monoxide Poisoning; Combined Modality Therapy; Dexamethasone; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Young Adult | 2020 |
Novel α-Lipoic Acid/3-
Topics: Benzofurans; Cell Line, Tumor; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Reactive Oxygen Species; Thioctic Acid | 2020 |
3‑N‑Butyphthalide improves learning and memory in rats with vascular cognitive impairment by activating the SIRT1/BDNF pathway.
Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dementia, Vascular; Male; Maze Learning; Memory; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1 | 2020 |
Does butylphthalide affect on hemodynamics in patients with watershed stroke?: A protocol of systematic review and meta-analysis.
Topics: Benzofurans; China; Hemodynamics; Humans; Meta-Analysis as Topic; Neuroprotective Agents; Quality of Life; Randomized Controlled Trials as Topic; Stroke; Systematic Review as Topic; Treatment Outcome | 2020 |
The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression.
Topics: Animals; Benzofurans; Depression; Hippocampus; Inflammation; Lipid Metabolism; Lipidomics; Lipopolysaccharides; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2020 |
Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage.
Topics: Animals; Benzofurans; Brain; Cerebral Hemorrhage; Disease Models, Animal; Male; Nervous System Diseases; Rats, Sprague-Dawley; Stroke; Vascular Endothelial Growth Factor A | 2020 |
L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model.
Topics: Animals; Anti-Inflammatory Agents; Apium; Benzofurans; Blood-Brain Barrier; Brain Edema; Cerebral Hemorrhage; Disease Models, Animal; Humans; Infusions, Intraventricular; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Permeability; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats.
Topics: Acetylcholinesterase; Animals; Benzofurans; Brain Ischemia; China; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Neurons; Cognitive Dysfunction; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2020 |
From Seeds of
Topics: Animals; Apium; Asthma; Benzofurans; Brain Ischemia; Humans; Neuroprotective Agents; Seeds; Stereoisomerism; Stroke | 2020 |
Dl-3-n-butylphthalide attenuates hypoxic-ischemic brain injury through inhibiting endoplasmic reticulum stress-induced cell apoptosis and alleviating blood-brain barrier disruption in newborn rats.
Topics: Animals; Animals, Newborn; Apoptosis; Benzofurans; Blood-Brain Barrier; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tight Junction Proteins | 2020 |
Effect of butylphthalide on new cerebral microbleeds in patients with acute ischemic stroke.
Topics: Benzofurans; Cerebral Hemorrhage; Clinical Protocols; Humans; Ischemia; Magnetic Resonance Imaging; Platelet Aggregation Inhibitors; Prospective Studies; Stroke | 2020 |
Use of l-3-n-Butylphthalide within 24 h after intravenous thrombolysis for acute cerebral infarction.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzofurans; Capsules; Cerebral Infarction; Female; Humans; Male; Middle Aged; Thrombolytic Therapy; Time Factors; Tissue Plasminogen Activator | 2020 |
Vascular protection and regenerative effects of intranasal DL-3-N-butylphthalide treatment after ischaemic stroke in mice.
Topics: Animals; Benzofurans; Brain Ischemia; Ischemic Stroke; Mice; Mice, Inbred C57BL; Stroke; Vascular Endothelial Growth Factor A | 2021 |
Acute bilateral cerebral infarction in the presence of neuromyelitis optica spectrum disorder: A case report.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Anticholesteremic Agents; Aphasia, Broca; Aspirin; Atorvastatin; Benzofurans; Cerebral Infarction; Female; Humans; Magnetic Resonance Imaging; Methylprednisolone; Middle Aged; Neuromyelitis Optica; Neuroprotective Agents; Plasmapheresis; Platelet Aggregation Inhibitors; Treatment Outcome | 2020 |
Effects of Dengzhan Shengmai Capsule combined with butylphthalide soft capsule on oxidative stress indexes and serum Hcy and CRP levels in patients with vascular dementia.
Topics: Aged; Benzofurans; C-Reactive Protein; Dementia, Vascular; Drugs, Chinese Herbal; Female; Homocysteine; Humans; Male; Malondialdehyde; Middle Aged; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase | 2020 |
L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer's disease mouse model and cultured hippocampal neurons.
Topics: Alzheimer Disease; Animals; Autophagosomes; Autophagy; Axons; Benzofurans; Biomarkers; Cells, Cultured; Cognitive Dysfunction; Dendritic Spines; Disease Models, Animal; Hippocampus; Long-Term Potentiation; Lysosomes; Male; Mice, Transgenic; Morris Water Maze Test; Neurites; Neuronal Plasticity; Synapses | 2021 |
Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis.
Topics: Animals; Benzofurans; Brain Ischemia; Humans; Infarction, Middle Cerebral Artery; Neuroprotective Agents; Rats; Reperfusion Injury | 2021 |
Efficacy and safety of butylphthalide as adjunctive therapy for vascular dementia: A protocol for systematic review and meta-analysis.
Topics: Benzofurans; Clinical Protocols; Dementia, Vascular; Humans; Meta-Analysis as Topic; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic; Systematic Reviews as Topic; Treatment Outcome | 2020 |
L-3-n-Butylphthalide Effectively Improves the Glymphatic Clearance and Reduce Amyloid-β Deposition in Alzheimer's Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzofurans; Brain; Glymphatic System; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neuroprotective Agents | 2021 |
Co-administration of TiO
Topics: Benzofurans; Brain Injuries, Traumatic; Humans; Mesenchymal Stem Cells; Neuroprotection; Parkinson Disease; Titanium | 2020 |
Dl-3-n-butylphthalide promotes neurite outgrowth of primary cortical neurons by Sonic Hedgehog signaling via upregulating Gap43.
Topics: Animals; Benzofurans; Cell Survival; Cells, Cultured; Female; GAP-43 Protein; Hedgehog Proteins; Mice; Mice, Inbred C57BL; Neuronal Outgrowth; Neuronal Plasticity; Neurons; Pregnancy; Signal Transduction; Up-Regulation | 2021 |
Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model.
Topics: Animals; Benzofurans; Brain; Caspase 1; Cyclic AMP Response Element-Binding Protein; Forkhead Transcription Factors; Infarction, Middle Cerebral Artery; Inflammation; Ischemic Stroke; Ki-67 Antigen; Molecular Docking Simulation; Neovascularization, Physiologic; Nerve Regeneration; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Phospholipids; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2021 |
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Topics: Animals; Apoptosis; Benzofurans; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Dendrites; Diabetes Mellitus, Type 2; Hippocampus; Male; Mice, Inbred C57BL; Morris Water Maze Test; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Synapses | 2021 |
Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer's Disease: A Multicenter, Prospective Cohort Study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Benzofurans; Cognitive Dysfunction; Cohort Studies; Donepezil; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Prospective Studies; Treatment Outcome | 2021 |
DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia.
Topics: Altitude Sickness; Animals; Benzofurans; Disease Models, Animal; Memory, Short-Term; Rats; Rats, Sprague-Dawley; Survival Analysis | 2021 |
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Topics: Animals; Apoptosis; Benzofurans; Brain Ischemia; Cell Line; Cell Line, Tumor; Drug Design; Edaravone; Glucose; Humans; Hydrogen Peroxide; Hypoxia; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Oxygen; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Dl-3-n-butylphthalide pretreatment attenuates renal ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Benzofurans; Caspase 3; Cell Hypoxia; Cell Survival; Creatinine; Disease Models, Animal; Immunohistochemistry; Inflammation; Kidney; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reperfusion Injury | 2021 |
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Topics: Animals; Apoptosis; Benzofurans; DNA Damage; Edaravone; Epithelial Cells; Intestine, Small; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Radiation-Protective Agents; Whole-Body Irradiation | 2021 |
Development of an LC-MS/MS method for simultaneous quantitative analysis of macromolecular pharmaceutical adjuvant 2-hydroxypropyl-β-cyclodextrin and active pharmaceutical ingredients butylphthalide in rat plasma.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adjuvants, Pharmaceutic; Animals; Benzofurans; beta-Cyclodextrins; Chromatography, Liquid; Plasma; Platelet Aggregation Inhibitors; Rats; Tandem Mass Spectrometry | 2021 |
Simultaneous determination of 3-n-butylphthalide and its metabolite 10-hydroxy-butylphthalide in rat plasma using liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study.
Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2021 |
DL-3-n-butylphthalide-induced neuroprotection in rat models of asphyxia-induced cardiac arrest followed by cardiopulmonary resuscitation.
Topics: Animals; Apoptosis; Asphyxia; Benzofurans; Brain Diseases; Cardiopulmonary Resuscitation; Disease Models, Animal; Heart Arrest; Hippocampus; JNK Mitogen-Activated Protein Kinases; Neurons; Neuroprotection; Neuroprotective Agents; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats, Sprague-Dawley; Return of Spontaneous Circulation; Signal Transduction; tau Proteins; Time Factors | 2021 |
Dl-3-n-butylphthalide Attenuates Spinal Cord Injury via Regulation of MMPs and Junction Proteins in Mice.
Topics: Animals; Benzofurans; Cell Hypoxia; Claudin-5; Female; Glucose; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Neuroprotective Agents; Occludin; Oxygen; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord; Spinal Cord Injuries; Tight Junction Proteins; Tight Junctions | 2021 |
Novel brain-targeting 3-n-butylphthalide prodrugs for ischemic stroke treatment.
Topics: Benzofurans; Brain; Brain Ischemia; Humans; Ischemic Stroke; Neuroprotective Agents; Prodrugs; Stroke | 2021 |
L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage.
Topics: Animals; Benzofurans; Cerebral Hemorrhage; Disease Models, Animal; Hemorrhagic Stroke; Humans; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2021 |
3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells.
Topics: Adipocytes; Adipose Tissue, White; Adiposity; Animals; Benzofurans; Blood Glucose; Cells, Cultured; Diet, High-Fat; Fatty Liver; Humans; Lipid Metabolism; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Protective Agents; Thermogenesis | 2021 |
Neuroprotective effect and mechanism of butylphthalide after cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Benzofurans; Brain Ischemia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2021 |
Dl-3-n-butylphthalide improves neurological function of a cardiac arrest patient with hypoxic-ischemic encephalopathy: a case report.
Topics: Benzofurans; Heart Arrest; Humans; Hypoxia-Ischemia, Brain | 2021 |
Fuzzy
Topics: Algorithms; Benzofurans; Biomarkers; Cerebral Infarction; Drug Therapy, Combination; Edaravone; Endothelium, Vascular; Female; Follow-Up Studies; Fuzzy Logic; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuroprotective Agents; Prognosis | 2021 |
Antidepressant-like Effect of 3-n-Butylphthalide in Rats Exposed to Chronic Unpredictable Mild Stress: Modulation of Brain-Derived Neurotrophic Factor Level and mTOR Activation in Cortex.
Topics: Animals; Antidepressive Agents; Benzofurans; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Chronic Disease; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Stress, Psychological; TOR Serine-Threonine Kinases; Treatment Outcome | 2021 |
N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Benzofurans; Biomarkers; Brain Ischemia; Case-Control Studies; Female; Humans; Ischemic Stroke; Kallikreins; Male; Middle Aged; Neuroprotective Agents; Prognosis; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Young Adult | 2021 |
Absorption, distribution, metabolism, and excretion of [
Topics: Administration, Oral; Animals; Benzofurans; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Feces; Female; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2021 |
Combination of tetrandrine and 3-n-butylphthalide protects against cerebral ischemia-reperfusion injury via ATF2/TLR4 pathway.
Topics: Activating Transcription Factor 2; Animals; Benzofurans; Benzylisoquinolines; Brain Ischemia; Cells, Cultured; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4 | 2021 |
Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke.
Topics: Animals; Apoptosis Regulatory Proteins; Benzofurans; Brain Ischemia; Disease Models, Animal; Drug Therapy, Combination; Edaravone; Endothelial Cells; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents | 2021 |
Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.
Topics: Benzofurans; Brain; Dose-Response Relationship, Drug; Drug Discovery; Humans; Molecular Structure; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Stroke; Structure-Activity Relationship | 2022 |
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Benzofurans; Binding Sites; Cells, Cultured; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Glutathione; Hepatocytes; Humans; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley | 2021 |
Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy.
Topics: Animals; Area Under Curve; Benzofurans; Caco-2 Cells; Chemistry, Pharmaceutical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Humans; Ischemic Stroke; Liposomes; Male; Neuroprotective Agents; Particle Size; Random Allocation; Rats; Rats, Sprague-Dawley; Sodium Cholate; Tissue Distribution | 2021 |
Dl-3-N-Butylphthalide Attenuates Hypoxic Injury of Neural Stem Cells by Increasing Hypoxia-Inducible Factor-1alpha.
Topics: Animals; Benzofurans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neural Stem Cells; Neuroprotective Agents; Rats | 2022 |
Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson's Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.
Topics: alpha-Synuclein; Animals; Apoptosis; Benzofurans; Cell Line; Disease Models, Animal; Dopaminergic Neurons; Humans; Inflammasomes; Mice; Mitochondria; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Parkinson Disease; Protein Aggregation, Pathological | 2021 |
Potential Protective Effect of Dl-3-n-butylphthalide on Chronic Cerebral Ischemia Brain Injury.
Topics: Benzofurans; Brain Injuries; Brain Ischemia; Humans; Neuroprotective Agents | 2022 |
DL-3-n-butylphthalide promotes hippocampal neurogenesis and reduces mossy fiber sprouting in chronic temporal lobe epilepsy rats.
Topics: Animals; Benzofurans; Epilepsy, Temporal Lobe; Hippocampus; Mice; Mossy Fibers, Hippocampal; Neurogenesis; Rats | 2022 |
DL-3-n-butylphthalide imparts neuroprotection via Nrf2/SIRT3 pathway in a mouse model of vascular dementia.
Topics: Animals; Apoptosis; Autophagy; Benzofurans; CA1 Region, Hippocampal; Dementia, Vascular; Disease Models, Animal; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Sirtuin 3 | 2022 |
Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance.
Topics: Animals; Benzofurans; Brain Injuries; Brain Ischemia; Drainage; Endothelial Cells; Evans Blue; Infarction, Middle Cerebral Artery; Ischemic Stroke; Rats; Rats, Sprague-Dawley; Stroke | 2022 |
Effects of butylphthalide on the levels of serum C-reactive protein, Parkinson disease protein 7 and neurotrophin-3 and neurological function in patients with acute cerebral infarction.
Topics: Aged; Benzofurans; C-Reactive Protein; Cerebral Infarction; Female; Gene Expression Regulation; Humans; Male; Neuroprotective Agents; Neurotrophin 3; Protein Deglycase DJ-1 | 2022 |
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction.
Topics: Animals; Atherosclerosis; Benzofurans; Brain Ischemia; Endothelial Cells; Mice; Neuroprotective Agents; Oxidative Stress; Rats; Stroke | 2022 |
CaMKIIα Signaling Is Required for the Neuroprotective Effects of Dl-3-n-Butylphthalide in Alzheimer's Disease.
Topics: Alzheimer Disease; Benzofurans; Humans; Neurodegenerative Diseases; Neuroprotective Agents | 2022 |
Effects of Butylphthalide Sodium Chloride Injection Combined with Edaravone Dexborneol on Neurological Function and Serum Inflammatory Factor Levels in Sufferers Having Acute Ischemic Stroke.
Topics: Benzofurans; Edaravone; Humans; Interleukin-6; Ischemic Stroke; Quality of Life; Sodium Chloride; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha | 2022 |
Cerebral hemodynamic changes assessment by transcranial doppler ultrasound in patients with acute cerebral infarction before and after treatment with butylphthalide.
Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Hemodynamics; Humans; Stroke; Ultrasonography, Doppler, Transcranial | 2022 |
Topics: Animals; Benzofurans; Chemical and Drug Induced Liver Injury; Ischemia; Ischemic Stroke; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Rats; Stroke | 2022 |
Synthesis and biological evaluation of hybrids from optically active ring-opened 3-N-butylphthalide derivatives and 4-fluro-edaravone as potential anti-acute ischemic stroke agents.
Topics: Animals; Benzofurans; Edaravone; Ischemic Stroke; Neuroprotective Agents; Rats; Stroke | 2022 |
A combination of tetramethylpyrazine hydrochloride and butylphthalide on serum S100B, CRP, Hcy levels and NIHSS score in patients with acute cerebral infarction: A retrospective study.
Topics: Acute Disease; Benzofurans; Brain Ischemia; Cerebral Infarction; Humans; Pyrazines; Retrospective Studies; S100 Calcium Binding Protein beta Subunit; Stroke | 2022 |
[Research progress on pharmacology of butylphthalide and its derivatives].
Topics: Benzofurans; Humans; Nervous System Diseases; Neuroprotective Agents; Oxidative Stress | 2022 |
DL-3-N-Butylphthalide Promotes Cartilage Extracellular Matrix Synthesis and Inhibits Osteoarthritis Development by Regulating FoxO3a.
Topics: Aged; Animals; Benzofurans; Cartilage, Articular; Chondrocytes; Extracellular Matrix; Forkhead Box Protein O3; Humans; Osteoarthritis; Phosphatidylinositol 3-Kinases; Rats | 2022 |
Clinical efficacy analysis of butylphthalide combined with urinary kallidinogenase in treating chronic cerebral circulatory insufficiency.
Topics: Benzofurans; Blood Flow Velocity; Cerebrovascular Circulation; Humans; Platelet Aggregation Inhibitors; Retrospective Studies; Tissue Kallikreins; Treatment Outcome | 2023 |
Efficacy of Butylphthalide in Combination with Edaravone in the Treatment of Acute Ischemic Stroke and the Effect on Serum Inflammatory Factors.
Topics: Benzofurans; Edaravone; Humans; Inflammation; Interleukin-6; Ischemic Stroke; Stroke | 2023 |