Page last updated: 2024-09-05

3-n-butyl-4,5-dihydrophthalide and ligustilide

3-n-butyl-4,5-dihydrophthalide has been researched along with ligustilide in 18 studies

Compound Research Comparison

Studies
(3-n-butyl-4,5-dihydrophthalide)
Trials
(3-n-butyl-4,5-dihydrophthalide)
Recent Studies (post-2010)
(3-n-butyl-4,5-dihydrophthalide)
Studies
(ligustilide)
Trials
(ligustilide)
Recent Studies (post-2010) (ligustilide)
450232230150

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's1 (5.56)18.2507
2000's5 (27.78)29.6817
2010's9 (50.00)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Harada, M; Ozaki, Y; Sekita, S1
Kimura, I; Kimura, M; Kobayashi, S; Mimura, Y; Naitoh, T1
Chen, BM; He, YK; Hu, QN; Li, BY; Liang, YZ; Wang, YL1
Cao, J; Ding, M; Kou, H; Wang, Z; Yang, X1
Chan, SS; Cheng, TY; Lin, G1
Liang, XM; Xiao, YS; Xu, Q; Xue, XY; Yang, F; Zhang, FF1
Chen, C; Du, JR; Tang, J; Wang, CY; Yang, W; Yu, Y1
Lau, AS; Law, AH; Li, JC; Or, TC; Yang, CL1
Ding, W; Duan, J; Liu, P; Qian, D; Shang, E; Tang, Y; Wu, J1
Li, YB; Lou, JS; Su, LN; Wang, YM1
Fan, QJ; Kong, FL; Liu, JL; Tan, J; Yang, SM; Yuan, JC; Zheng, SL; Zhou, J1
Cai, H; Pei, K; Qiao, FX; Song, XQ; Tu, PF1
Chen, Y; Huang, ZF; Liu, YH; Yang, Y; Yi, JH1
Hu, PY; Liu, D; Tang, Y; Wu, Q; Yang, M; Zheng, Q1
Bai, G; Deng, YF; Hu, XY; Jiang, M; Lei, W; Ni, JN1
Hu, N; Jiang, W; Liu, L; Shi, L; Wang, Q; Yan, T; Yang, P; Zhang, S; Zhang, W1
An, C; Dong, Y; Li, M; Li, X; Wang, X; Xiang, F; Yao, Y1
Chen, J; Jin, L; Shi, T; Xu, X; Zhu, T1

Other Studies

18 other study(ies) available for 3-n-butyl-4,5-dihydrophthalide and ligustilide

ArticleYear
[Centrally acting muscle relaxant effect of phthalides (ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1989, Volume: 109, Issue:6

    Topics: 4-Butyrolactone; Animals; Benzofurans; Drugs, Chinese Herbal; Furans; Male; Mephenesin; Muscle Relaxants, Central; Rats; Rats, Inbred Strains

1989
Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:3

    Topics: 4-Butyrolactone; Analysis of Variance; Animals; Aorta, Thoracic; Benzofurans; Cell Division; Cells, Cultured; Drugs, Chinese Herbal; Male; Mice; Muscle, Smooth, Vascular; Phthalic Anhydrides; Structure-Activity Relationship

1993
LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.
    Analytical and bioanalytical chemistry, 2005, Volume: 383, Issue:2

    Topics: 4-Butyrolactone; Absorption; Administration, Oral; Aldehydes; alpha-Linolenic Acid; Angelica sinensis; Animals; Benzofurans; Diynes; Drugs, Chinese Herbal; Fatty Alcohols; Linoleic Acid; Mass Spectrometry; Phthalic Anhydrides; Plant Extracts; Rabbits

2005
[Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 2005, Volume: 23, Issue:5

    Topics: 4-Butyrolactone; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lactones; Ligusticum; Reproducibility of Results

2005
Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
    Journal of ethnopharmacology, 2007, May-22, Volume: 111, Issue:3

    Topics: 4-Butyrolactone; Animals; Aorta, Thoracic; Benzofurans; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Ligusticum; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents

2007
[High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:11

    Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Molecular Structure; Phthalic Anhydrides; Plant Roots; Plants, Medicinal; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization

2006
[Pharmacological activities of Z-ligustilide and metabolites in rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009, Volume: 40, Issue:5

    Topics: 4-Butyrolactone; Animals; Benzofurans; Biotransformation; Hydrogen Peroxide; Male; Microsomes, Liver; Oxidative Stress; PC12 Cells; Protective Agents; Rats; Rats, Sprague-Dawley

2009
Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia.
    Neuropharmacology, 2011, Volume: 60, Issue:6

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Biological Assay; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Ligusticum; Lipopolysaccharides; Mice; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Tumor Necrosis Factor-alpha

2011
[Influence of different solutions on extracting of active components in Danggui Chishao drug pair].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:7

    Topics: 4-Butyrolactone; Benzoates; Benzofurans; Bridged-Ring Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Gallic Acid; Glucosides; Hydroxybenzoates; Mass Spectrometry; Monoterpenes; Phthalic Acids; Solvents; Vanillic Acid

2012
[Study on the constituents of essential oil of Shunaoxin dropping pills by GC-MS].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2013, Volume: 36, Issue:3

    Topics: 4-Butyrolactone; Angelica; Apiaceae; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Oils, Volatile; Phthalic Anhydrides

2013
[Quantitative determination of 5 active ingredients in different harvest periods of Ligusticum chuanxiong by HPLC].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:9

    Topics: 4-Butyrolactone; Acetic Acid; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Ligusticum; Methanol; Solvents; Time Factors

2014
[Establishment and application of HPLC-QAMS for quality evaluation of Chuanxiong Rhizoma].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:6

    Topics: 4-Butyrolactone; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydroxybenzoates; Quality Control; Rhizome

2015
[Comparative Study on Volatile Oil Composition of Chuanxiong Rhizoma, Angelicae Sinensis Radix and Ligustici Rhizoma et Radix].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, Volume: 38, Issue:6

    Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ligusticum; Oils, Volatile; Phthalic Anhydrides; Plant Oils; Plant Roots; Rhizome

2015
Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model.
    Molecules (Basel, Switzerland), 2016, Mar-02, Volume: 21, Issue:3

    Topics: 4-Butyrolactone; Animals; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Biological Transport; Blood-Brain Barrier; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucosides; Humans; In Vitro Techniques; Madin Darby Canine Kidney Cells; Molecular Structure; Monoterpenes

2016
Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 117

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Benzofurans; HEK293 Cells; Humans; Immunologic Factors; Inflammation Mediators; Lipids; Male; Mice, Inbred C57BL; NF-kappa B; Proto-Oncogene Proteins c-akt; Transcription Factor AP-1; Tumor Necrosis Factor Receptor Superfamily, Member 9

2019
Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.
    Biomedical chromatography : BMC, 2019, Volume: 33, Issue:10

    Topics: 4-Butyrolactone; Administration, Oral; Animals; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results

2019
Simultaneous determination of 20 bioactive components in Chuanxiong Rhizoma from different production origins in Sichuan province by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry combined with multivariate s
    Electrophoresis, 2020, Volume: 41, Issue:18-19

    Topics: 4-Butyrolactone; Benzofurans; China; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Geography; Limit of Detection; Linear Models; Multivariate Analysis; Reproducibility of Results; Tandem Mass Spectrometry

2020
Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; China; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Plant Extracts

2020