3-n-butyl-4,5-dihydrophthalide has been researched along with benzofurans in 40 studies
| Studies (3-n-butyl-4,5-dihydrophthalide) | Trials (3-n-butyl-4,5-dihydrophthalide) | Recent Studies (post-2010) (3-n-butyl-4,5-dihydrophthalide) | Studies (benzofurans) | Trials (benzofurans) | Recent Studies (post-2010) (benzofurans) |
|---|---|---|---|---|---|
| 45 | 0 | 23 | 13,293 | 451 | 4,970 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.00) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 11 (27.50) | 29.6817 |
| 2010's | 21 (52.50) | 24.3611 |
| 2020's | 3 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Harada, M; Ozaki, Y; Sekita, S | 1 |
| You, SQ; Yu, SR | 1 |
| Li, QS; Pan, JG; Xiong, WS; Yi, YH | 1 |
| Kimura, I; Kimura, M; Kobayashi, S; Mimura, Y; Naitoh, T | 1 |
| Peng, X; Su, D; Wei, G; Zhang, J | 1 |
| Momin, RA; Nair, MG | 1 |
| Liang, X; Xiao, H; Xu, Q; Zhang, X | 1 |
| Chen, BM; He, YK; Hu, QN; Li, BY; Liang, YZ; Wang, YL | 1 |
| Chan, K; Leung, KS; Lu, GH; Yi, T; Zhang, H | 1 |
| Cao, J; Ding, M; Kou, H; Wang, Z; Yang, X | 1 |
| Chan, SS; Cheng, TY; Lin, G | 1 |
| Liang, XM; Xiao, YS; Xu, Q; Xue, XY; Yang, F; Zhang, FF | 1 |
| Ko, NL; Lin, G; Tam, YK; Yan, R | 1 |
| Fujita, A; Katsumi, Y; Kubota, K; Kurobayashi, Y; Morimitsu, Y | 1 |
| Liang, H; Lu, XH; Zhang, JJ; Zhang, XX; Zhao, YY | 1 |
| Chen, C; Du, JR; Tang, J; Wang, CY; Yang, W; Yu, Y | 1 |
| Chen, Y; Chu, IK; Han, Y; Lau, AS; Qi, H; Rong, J; Siu, SO; Tong, Y | 1 |
| Ding, A; Duan, JA; Guo, J; Guo, S; Qian, D; Shang, E; Su, S; Tang, Y; Zhu, M | 1 |
| Lau, AS; Law, AH; Li, JC; Or, TC; Yang, CL | 1 |
| Feng, Y; He, CY; Hong, YL; Liang, S; Lin, X; Wang, YH; Xu, DS | 1 |
| Oguro, D; Watanabe, H | 1 |
| Feng, Y; Lin, X; Wei, Y; Zhang, N | 1 |
| Bae, KE; Choi, YW; Kim, ST; Kim, YK | 1 |
| Hu, J; Li, H; Liu, J; Wei, Y | 1 |
| Feng, Y; Lin, X; Wei, YF; Zhang, N | 1 |
| Ding, W; Duan, J; Liu, P; Qian, D; Shang, E; Tang, Y; Wu, J | 1 |
| Li, YB; Lou, JS; Su, LN; Wang, YM | 1 |
| Fan, QJ; Kong, FL; Liu, JL; Yang, SM; Yuan, JC; Zheng, SL | 1 |
| Fan, QJ; Kong, FL; Liu, JL; Tan, J; Yang, SM; Yuan, JC; Zheng, SL; Zhou, J | 1 |
| Cai, H; Pei, K; Qiao, FX; Song, XQ; Tu, PF | 1 |
| Chen, Y; Huang, ZF; Liu, YH; Yang, Y; Yi, JH | 1 |
| Hu, PY; Liu, D; Tang, Y; Wu, Q; Yang, M; Zheng, Q | 1 |
| Doridot, E; Genet, V; Mondon, P; Ringenbach, C | 1 |
| Fang, Y; Jin, Y; Li, M; Sun, Y; Wang, Q; Wang, R; Xie, S; Yang, S; Yang, Z | 1 |
| Fu, W; Gong, S; Guo, Z; Zhang, J | 1 |
| Bai, G; Deng, YF; Hu, XY; Jiang, M; Lei, W; Ni, JN | 1 |
| Hu, N; Jiang, W; Liu, L; Shi, L; Wang, Q; Yan, T; Yang, P; Zhang, S; Zhang, W | 1 |
| An, C; Dong, Y; Li, M; Li, X; Wang, X; Xiang, F; Yao, Y | 1 |
| Liu, C; Sui, Y; Wang, M; Zhang, H | 1 |
| Chen, J; Jin, L; Shi, T; Xu, X; Zhu, T | 1 |
40 other study(ies) available for 3-n-butyl-4,5-dihydrophthalide and benzofurans
| Article | Year |
|---|---|
[Centrally acting muscle relaxant effect of phthalides (ligustilide, cnidilide and senkyunolide) obtained from Cnidium officinale Makino].
Topics: 4-Butyrolactone; Animals; Benzofurans; Drugs, Chinese Herbal; Furans; Male; Mephenesin; Muscle Relaxants, Central; Rats; Rats, Inbred Strains | 1989 |
[The anticonvulsant action of 3-n-butylphthalide (Ag-1) and 3-n-butyl-4, 5-dihydrophthalide (Ag-2)].
Topics: Animals; Anticonvulsants; Benzofurans; China; Electroshock; Female; Male; Mice; Plants, Medicinal; Rats; Structure-Activity Relationship | 1984 |
[Studies on the chemical components of the rhizome of Ligusticum sinense Oliv. cv. chaxiong].
Topics: Benzofurans; Drugs, Chinese Herbal; Palmitic Acids | 1993 |
Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells.
Topics: 4-Butyrolactone; Analysis of Variance; Animals; Aorta, Thoracic; Benzofurans; Cell Division; Cells, Cultured; Drugs, Chinese Herbal; Male; Mice; Muscle, Smooth, Vascular; Phthalic Anhydrides; Structure-Activity Relationship | 1993 |
NBPA: a cerebral ischaemic protective agent.
Topics: Animals; Benzofurans; Brain Ischemia; Calcium Channel Blockers; Energy Metabolism; Enzyme Activation; Gene Expression Regulation; Genes, fos; Glutamic Acid; Guinea Pigs; HSP70 Heat-Shock Proteins; Humans; Myocardium; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Rats; Tumor Cells, Cultured | 1999 |
Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds.
Topics: Aedes; Animals; Antifungal Agents; Antinematodal Agents; Apiaceae; Benzofurans; Caenorhabditis elegans; Candida; Insecticides; Methanol; Nematoda; Plant Extracts; Seeds | 2001 |
[Preparation of senkyunolide I by reversed-phase high performance liquid chromatography].
Topics: Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ligusticum | 2004 |
LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.
Topics: 4-Butyrolactone; Absorption; Administration, Oral; Aldehydes; alpha-Linolenic Acid; Angelica sinensis; Animals; Benzofurans; Diynes; Drugs, Chinese Herbal; Fatty Alcohols; Linoleic Acid; Mass Spectrometry; Phthalic Anhydrides; Plant Extracts; Rabbits | 2005 |
Identification and comparative determination of senkyunolide A in traditional Chinese medicinal plants Ligusticum chuanxiong and Angelica sinensis by HPLC coupled with DAD and ESI-MS.
Topics: Angelica; Benzofurans; Calibration; Chromatography, High Pressure Liquid; Ligusticum; Reference Standards; Reproducibility of Results; Solutions; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2005 |
[Determination of lactone components in chuanxiong by reversed-phase high performance liquid chromatography].
Topics: 4-Butyrolactone; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Lactones; Ligusticum; Reproducibility of Results | 2005 |
Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
Topics: 4-Butyrolactone; Animals; Aorta, Thoracic; Benzofurans; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Ligusticum; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 2007 |
[High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Molecular Structure; Phthalic Anhydrides; Plant Roots; Plants, Medicinal; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2006 |
Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat.
Topics: Administration, Oral; Animals; Area Under Curve; Benzofurans; Biological Availability; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Gastric Acid; Half-Life; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Ligusticum; Male; Mass Spectrometry; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Molecular Structure; Rats; Rats, Sprague-Dawley; Rhizome; Tissue Distribution | 2007 |
Flavor enhancement of chicken broth from boiled celery constituents.
Topics: Animals; Apium; Benzofurans; Chickens; Hot Temperature; Humans; Meat; Odorants; Solutions; Taste; Volatilization | 2008 |
[Study on biligustilides from Angelica sinensis].
Topics: Angelica sinensis; Benzofurans; Drugs, Chinese Herbal; Molecular Structure | 2008 |
[Pharmacological activities of Z-ligustilide and metabolites in rats].
Topics: 4-Butyrolactone; Animals; Benzofurans; Biotransformation; Hydrogen Peroxide; Male; Microsomes, Liver; Oxidative Stress; PC12 Cells; Protective Agents; Rats; Rats, Sprague-Dawley | 2009 |
Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1.
Topics: Benzofurans; Enzyme Inhibitors; Heme Oxygenase-1; Hep G2 Cells; Humans; Hydrogen Peroxide; Lipid Peroxidation; Metalloporphyrins; Oxidative Stress; Protoporphyrins; Reactive Oxygen Species; Stereoisomerism | 2010 |
Roles of paeoniflorin and senkyunolide I in SiWu decoction on antiplatelet and anticoagulation activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Benzoates; Benzofurans; Bridged-Ring Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Humans; Male; Medicine, Chinese Traditional; Molecular Structure; Monoterpenes; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombin Time | 2010 |
Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Biological Assay; Cell Line, Tumor; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Ligusticum; Lipopolysaccharides; Mice; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Tumor Necrosis Factor-alpha | 2011 |
Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong.
Topics: 5-Hydroxytryptophan; Acetates; Analgesics; Animals; Benzofurans; Brain; Dopamine; Drugs, Chinese Herbal; Hydroxyindoleacetic Acid; Ligusticum; Mice; Migraine Disorders; Neurotransmitter Agents; Nitric Oxide; Nitroglycerin; Norepinephrine; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin | 2011 |
Asymmetric synthesis and sensory evaluation of sedanenolide.
Topics: Alkynes; Apium; Benzofurans; Cyclization; Food Additives; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Odorants; Propanols; Sensory Thresholds; Stereoisomerism; Taste; Taste Perception | 2011 |
[UPLC-MS analysis of constituents of dachuanxiong fang active parts absorbed into blood].
Topics: Animals; Benzofurans; Benzyl Alcohols; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Glucosides; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley | 2011 |
Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Benzofurans; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cnidium; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diynes; Fatty Alcohols; Female; Humans; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Plant Extracts; Rhizome; RNA, Messenger; Tumor Suppressor Protein p53 | 2011 |
Preparative isolation and purification of senkyunolide-I, senkyunolide-H and ferulic acid from Rhizoma Chuanxiong using counter-current chromatography.
Topics: Benzofurans; Coumaric Acids; Countercurrent Distribution; Drugs, Chinese Herbal; Ligusticum; Rhizome | 2011 |
[Release characteristics in vitro and pharmacokinetics of da chuanxiong fang multiunit drug delivery system in rats].
Topics: Animals; Area Under Curve; Benzofurans; Coumaric Acids; Drug Delivery Systems; Drugs, Chinese Herbal; Female; Gastrodia; Ligusticum; Male; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2011 |
[Influence of different solutions on extracting of active components in Danggui Chishao drug pair].
Topics: 4-Butyrolactone; Benzoates; Benzofurans; Bridged-Ring Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Gallic Acid; Glucosides; Hydroxybenzoates; Mass Spectrometry; Monoterpenes; Phthalic Acids; Solvents; Vanillic Acid | 2012 |
[Study on the constituents of essential oil of Shunaoxin dropping pills by GC-MS].
Topics: 4-Butyrolactone; Angelica; Apiaceae; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Oils, Volatile; Phthalic Anhydrides | 2013 |
Optimization of high-pressure ultrasonic-assisted simultaneous extraction of six major constituents from Ligusticum chuanxiong rhizome using response surface methodology.
Topics: Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Ligusticum; Plant Extracts; Regression Analysis; Rhizome; Ultrasonics | 2014 |
[Quantitative determination of 5 active ingredients in different harvest periods of Ligusticum chuanxiong by HPLC].
Topics: 4-Butyrolactone; Acetic Acid; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Ligusticum; Methanol; Solvents; Time Factors | 2014 |
[Establishment and application of HPLC-QAMS for quality evaluation of Chuanxiong Rhizoma].
Topics: 4-Butyrolactone; Acetonitriles; Benzofurans; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Hydroxybenzoates; Quality Control; Rhizome | 2015 |
[Comparative Study on Volatile Oil Composition of Chuanxiong Rhizoma, Angelicae Sinensis Radix and Ligustici Rhizoma et Radix].
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ligusticum; Oils, Volatile; Phthalic Anhydrides; Plant Oils; Plant Roots; Rhizome | 2015 |
Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model.
Topics: 4-Butyrolactone; Animals; ATP Binding Cassette Transporter, Subfamily B; Benzofurans; Biological Transport; Blood-Brain Barrier; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucosides; Humans; In Vitro Techniques; Madin Darby Canine Kidney Cells; Molecular Structure; Monoterpenes | 2016 |
Reinforcement of barrier function and scalp homeostasis by Senkyunolide A to fight against dandruff.
Topics: Benzofurans; Dandruff; Filaggrin Proteins; Homeostasis; Humans; In Vitro Techniques; Scalp | 2017 |
Design and synthesis of novel senkyunolide analogues as neuroprotective agents.
Topics: Animals; Antioxidants; Benzofurans; Cell Line; Coumaric Acids; Drug Design; Mice; Molecular Structure; Neuroprotective Agents; Nitric Oxide Donors; Oxadiazoles; Oxidative Stress | 2018 |
Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling.
Topics: alpha-Synuclein; Animals; Apoptosis; Benzofurans; Corticosterone; Neuroprotective Agents; PC12 Cells; Phosphorylation; Protein Phosphatase 2; Rats; Signal Transduction | 2018 |
Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Benzofurans; HEK293 Cells; Humans; Immunologic Factors; Inflammation Mediators; Lipids; Male; Mice, Inbred C57BL; NF-kappa B; Proto-Oncogene Proteins c-akt; Transcription Factor AP-1; Tumor Necrosis Factor Receptor Superfamily, Member 9 | 2019 |
Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Benzofurans; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Limit of Detection; Linear Models; Male; Rats; Rats, Sprague-Dawley; Reproducibility of Results | 2019 |
Simultaneous determination of 20 bioactive components in Chuanxiong Rhizoma from different production origins in Sichuan province by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry combined with multivariate s
Topics: 4-Butyrolactone; Benzofurans; China; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Geography; Limit of Detection; Linear Models; Multivariate Analysis; Reproducibility of Results; Tandem Mass Spectrometry | 2020 |
Metabolic profiling of senkyunolide A and identification of its metabolites in hepatocytes by ultra-high-performance liquid chromatography combined with diode-array detector and high-resolution mass spectrometry.
Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Dogs; Haplorhini; Hepatocytes; Humans; Mass Spectrometry; Metabolome; Metabolomics; Mice; Rats | 2020 |
Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
Topics: 4-Butyrolactone; Angelica sinensis; Benzofurans; China; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Plant Extracts | 2020 |