3-methylcholanthrene has been researched along with warfarin in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (75.93) | 18.7374 |
| 1990's | 10 (18.52) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Erdmann, F; Fischer, G; Harris, R; Hopkins, S; Huang, Z; Murray, MG; Ribeill, Y; Scorneaux, B; Smitley, C; Wring, S | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 2 |
| Imai, Y | 1 |
| Hietanen, E; Pelkonen, K | 1 |
| Glatt, HR; Oesch, F; Raphael, D; Schwind, H | 1 |
| Bridges, JW; Fry, JR; Kao, J; Shirkey, RJ | 1 |
| Andersson, B; Grafström, R; Moldéus, P; Orrenius, S | 1 |
| Greenlee, WF; Poland, A | 1 |
| Coon, MJ; Fasco, MJ; Kaminsky, LS; Vatsis, KP | 1 |
| Yang, CS | 1 |
| Pohl, LR; Porter, WR; Trager, WF | 1 |
| Levin, W; Lu, AY; Miwa, GT; Ryan, D; Thomas, PE; West, SB | 1 |
| Novikov, KN; Sumbalova, Z; Timofeev, KN | 1 |
| Kato, S; Yamamoto, K | 2 |
| Gann, KL; Jauregui, HO; Ng, SF; Waxman, DJ | 1 |
| Hermans, JJ; Thijssen, HH | 1 |
| Isobe, M; Ozawa, N; Sone, T; Takabatake, E; Watabe, T | 1 |
| Martin, LF; Patrick, SD; Wallin, R | 1 |
| White, IN | 1 |
| Adams, DJ; Dawson, JR; Wolf, CR | 1 |
| Harada, N; Lu, AY; Miwa, GT | 1 |
| Adams, DJ; Amelizad, Z; Oesch, F; Seilman, S; Wolf, CR | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Aitio, A; Vainio, H | 1 |
| Hänninen, O; Vainio, H | 1 |
| Feuer, G; Liscio, A | 2 |
| Feuer, G; Granda, V | 1 |
| Diaugustine, RP; Eling, TE; Fouts, JR | 1 |
| Conney, AH; Jacobson, M; Levin, W; Poppers, PJ; Wood, AW | 1 |
| Frommer, U; Ullrich, V; Weber, P | 1 |
| Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC | 1 |
| Hagmar, B | 3 |
| Ketcham, AS; Ryan, JJ; Wexler, H | 1 |
| Caveness, MB; Goldstein, JA; Sundheimer, DW | 1 |
| Borm, PJ; Frankhuijzen-Sierevogel, A; Koster, AS; Noordhoek, J | 1 |
| Borm, PJ; Frankhuijzen-Sierevogel, A; Noordhoek, J | 1 |
| Grafstöm, R; Stohs, SJ | 1 |
| Fasco, MJ; Guengerich, FP; Kaminsky, LS | 1 |
| Cashin, MJ; Fasco, MJ | 1 |
| Clement, B; Mladek, C | 1 |
| Amirkhosravi, M; Francis, JL | 1 |
| Bartsch, H; Kirby, GM; Lang, MA; Pelkonen, P; Wild, CP | 1 |
| Desager, JP; Harvengt, C; Horsmans, Y | 1 |
| Evans, JG; Lake, BG | 1 |
| Ashwood-Smith, MJ; Baer-Dubowska, W; Cai, Y; Ceska, O; DiGiovanni, J; Tachibana, S | 1 |
| Fujii, J; Hamada, J; Kobayashi, M; Kuramitsu, Y; Murakami, A; Nicolson, GL; Ogawara, S; Okada, F; Onuma, K; Sakaki, R; Sato, Y; Suenaga, Y; Suzuki, S; Yokoyama, H; Yoshitome, S | 1 |
54 other study(ies) available for 3-methylcholanthrene and warfarin
| Article | Year |
|---|---|
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cyclophilin A; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Haplorhini; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukocytes, Mononuclear; Mice; Molecular Structure; Rats; RNA, Viral; Virus Replication | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Catalysis; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethyl Ethers; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats | 1978 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
Reconstituted O-dealkylase systems containing various forms of liver microsomal cytochrome P-450.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Rabbits; Rats; Spectrophotometry | 1979 |
Hepatic and extrahepatic induction of drug-metabolizing enzymes in specific pathogen free and germ free rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethyl Ethers; Germ-Free Life; Glucuronosyltransferase; Intestinal Mucosa; Kidney; Liver; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Oxidoreductases, O-Demethylating; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms | 1979 |
Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.
Topics: Animals; Benzopyrenes; Biotransformation; Coumarins; Epoxide Hydrolases; Female; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Mutagens; Oxidoreductases; Phenobarbital; Rats; Salmonella typhimurium; Species Specificity | 1977 |
A comparison of xenobiotic metabolism in cells isolated from rat liver and small intestinal mucosa.
Topics: Aniline Compounds; Animals; Benzoates; Biotransformation; Coumarins; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Liver; Male; Methylcholanthrene; Phenobarbital; Phenols; Rats; Time Factors | 1979 |
Xenobiotic metabolism by isolated rat small intestinal cells.
Topics: Acetaminophen; Animals; Benzopyrenes; Biotransformation; Cell Separation; Coumarins; Cytochrome P-450 Enzyme System; Glucuronates; Harmine; Intestine, Small; Male; Methylcholanthrene; Oxazines; Rats | 1979 |
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Dioxins; Enzyme Induction; Ethyl Ethers; Kinetics; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oxygenases; Phenobarbital; Polychlorinated Dibenzodioxins; Spectrometry, Fluorescence | 1978 |
Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Flavonoids; Hydroxylation; Isomerism; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Phenobarbital; Rabbits; Structure-Activity Relationship; Warfarin | 1978 |
Interactions between solubilized cytochrome P-450 and hepatic microsomes.
Topics: Animals; Binding Sites; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Protein Binding; Rats; Solubility | 1977 |
Stereochemical biotransformation of warfarin as a probe of the homogeneity and mechanism of microsomal hydroxylases.
Topics: Animals; Biotransformation; Cytochromes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proteins; Rats; Stereoisomerism; Time Factors; Warfarin | 1977 |
Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.
Topics: Animals; Antibodies; Benzopyrenes; Benzphetamine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; In Vitro Techniques; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Phenobarbital; Rats; Testosterone | 1977 |
Binding of R and S warfarin to hepatic microsomal cytochrome P-450.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Warfarin | 1977 |
[The effect of lysolecithin on rat liver microsome monooxygenase activity after induction by xenobiotics of the methylcholanthrene type].
Topics: Animals; Anisoles; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Coumarins; Enzyme Induction; Hydroxylation; Intracellular Membranes; Lysophosphatidylcholines; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Polychlorinated Biphenyls; Rats; Substrate Specificity | 1992 |
Comparative effects of chloroflavone congeners as inducers of hepatic microsomal monooxygenases in rats.
Topics: Aminopyrine N-Demethylase; Animals; Coumarins; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism | 1992 |
Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Xenobiotics | 1991 |
Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4'-nitrowarfarin (acenocoumarol).
Topics: Acenocoumarol; Animals; Chromatography, High Pressure Liquid; Cimetidine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism; Warfarin | 1991 |
Using the scoparone O-demethylase assay for categorizing types of hepatic microsomal monooxygenase inducers.
Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1989 |
7-ethenyloxycoumarin as a new substrate for fluorophotometric assay of hepatic microsomal epoxidizing activities.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spectrophotometry; Umbelliferones | 1989 |
3-Methylcholanthrene induction of enzymes in the vitamin K-dependent carboxylation system.
Topics: Biomarkers; Carbon-Carbon Ligases; Cytosol; Enzyme Induction; Ligases; Liver; Methylcholanthrene; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Protein Precursors; Prothrombin; Quinone Reductases; Vitamin K; Warfarin | 1987 |
A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin.
Topics: Animals; Autoanalysis; Coumarins; Cytochrome P-450 Enzyme System; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitriles; Phenobarbital; Rats; Rats, Inbred F344 | 1988 |
Induction of drug metabolizing enzymes in human liver cell line Hep G2.
Topics: Cell Line; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Humans; Isoenzymes; Liver; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Sulfurtransferases | 1985 |
Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters.
Topics: Animals; Chromatography, High Pressure Liquid; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Induction; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Microsomes, Liver; Models, Biological; Oxidation-Reduction; Rats; Substrate Specificity | 1985 |
Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Oxazines; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
Enhancement of microsomal drug hydroxylation and glucuronidation in rat liver by phenobarbital and 3-methylcholanthrene in combination.
Topics: Animals; Anisoles; Benzopyrenes; Cetylpyridinium; Coumarins; Culture Media; Digitonin; Drug Synergism; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Oxygenases; Phenobarbital; Rats; Stimulation, Chemical; Trypsin | 1974 |
A comparative study on drug hydroxylation and glucuronidation in liver microsomes of phenobarbital and 3-methylcholanthrene treated rats.
Topics: Animals; Anisoles; Cetylpyridinium; Coumarins; Cytochrome P-450 Enzyme System; Digitonin; Drug Combinations; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Oxidoreductases; Phenobarbital; Phospholipases; Proteins; Stimulation, Chemical; Thiocyanates; Trypsin | 1974 |
Effect of drugs on hepatic drug metabolism in the fetus and newborn.
Topics: Animals; Animals, Newborn; Coumarins; Female; Fetus; Glucose-6-Phosphatase; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sleep; Transferases | 1970 |
Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat.
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Coumarins; Drug Antagonism; Enzymes; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Phosphoric Monoester Hydrolases; Rats; Toluene | 1970 |
The interaction of a fluorescent probe with rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Oxidoreductases; Phenobarbital; Rats; Sulfites; Sulfonic Acids; Warfarin | 1970 |
Comparison of the O-dealkylation of 7-ethoxycoumarin and the hydroxylation of benzo(a)pyrene in human placenta. Effect of cigarette smoking.
Topics: Animals; Benzopyrenes; Coumarins; Dealkylation; Enzyme Induction; Ethyl Ethers; Female; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Placenta; Pregnancy; Rats; Smoking; Time Factors | 1974 |
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1971 |
Experimental tumour metastases and blood coagulability.
Topics: Aminocaproates; Animals; Blood Coagulation; Coumarins; Female; Heparin; Lung Neoplasms; Male; Melanoma; Methylcholanthrene; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Protamines; Sarcoma, Experimental | 1970 |
Effect of heparin, coumarin and -aminocaproic acid (EACA) on spontaneous metastasis formation. Influence on the moment of metastasis formation. Possible cytotoxic effect of heparin and coumarin in blood.
Topics: Aminocaproates; Animals; Coumarins; Heparin; Lung Neoplasms; Lymphatic Metastasis; Methylcholanthrene; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Neoplastic Cells, Circulating; Rhabdomyosarcoma | 1969 |
Warfarin treatment of mice bearing autochthonous tumors: effect on spontaneous metastases.
Topics: Animals; Female; Lung Neoplasms; Methylcholanthrene; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Warfarin | 1968 |
Effect of heparin, epsilon-aminocaproic acid and coumarin on tumour growth and spontaneous metastasis formation.
Topics: Aminocaproates; Animals; Anticoagulants; Antifibrinolytic Agents; Coumarins; Heparin; Lung Neoplasms; Methylcholanthrene; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Rhabdomyosarcoma; Sarcoma, Experimental; Tail | 1968 |
Origin of delayed development of drug metabolism in the newborn rat.
Topics: Animals; Animals, Newborn; Coumarins; Female; Methylcholanthrene; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sleep; Time Factors | 1969 |
Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450.
Topics: Acetanilides; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
Comparison of two cell isolation procedures to study in vitro intestinal wall biotransformation in control and 3-methyl-cholanthrene pretreated rats.
Topics: Animals; Biotransformation; Cell Separation; Coumarins; In Vitro Techniques; Intestinal Mucosa; Male; Methylcholanthrene; Rats; Umbelliferones | 1983 |
Kinetics of in vitro O-deethylation of phenacetin and 7-ethoxycoumarin by rat intestinal mucosal cells and microsomes. The effect of induction with 3-methylcholanthrene and inhibition with alpha-naphthoflavone.
Topics: Animals; Benzoflavones; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Flavonoids; Humans; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Mice; Microsomes; Phenacetin; Rats; Rats, Inbred Strains | 1983 |
Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells.
Topics: Animals; Benzoflavones; Benzopyrenes; Coumarins; Cytochrome P-450 CYP1A1; Female; Intestine, Small; Methylcholanthrene; Metyrapone; Microsomes; Oxidoreductases; Proadifen; Rats; Rats, Inbred Strains; Rotenone | 1981 |
Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin.
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Stereoisomerism; Substrate Specificity; Warfarin | 1980 |
Effects of induction on R- and S-warfarin and metabolite concentrations in rat plasma.
Topics: Animals; Blood Coagulation; Enzyme Induction; Half-Life; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Stereoisomerism; Warfarin | 1980 |
[Biotransformation processes in fertile hen's eggs. 1. Metabolic transformation of 7-ethoxycoumarin].
Topics: Animals; Biotransformation; Chick Embryo; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronates; Methylcholanthrene; Ovalbumin; Phenobarbital; Sulfates | 1995 |
Procoagulant activity of the MC28 fibrosarcoma cell line in vitro and in vivo.
Topics: Animals; Blood Coagulation; Concanavalin A; Factor X; Fibrinogen; Fibrosarcoma; Hemoglobins; Heparin; Male; Methylcholanthrene; Platelet Aggregation; Platelet Count; Rats; Tumor Cells, Cultured; Warfarin | 1993 |
Metabolism of nitrosamines and aflatoxin B1 by hamster liver CYP2A enzymes.
Topics: Aflatoxin B1; Animals; Blotting, Western; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Kinetics; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Pyrazoles; Steroid Hydroxylases | 1994 |
Scoparone O-demethylase assay is not useful to differentiate the effects of model inducers of cytochrome P-450 in rabbit and guinea pig liver.
Topics: Animals; Biomarkers; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Humans; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, O-Demethylating; Phenobarbital; Rabbits; Rats; Rats, Wistar; Species Specificity | 1993 |
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins.
Topics: Animals; Anticoagulants; Anticonvulsants; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A1; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Furocoumarins; Heme; Humans; Hypnotics and Sedatives; Methylcholanthrene; Mice; Mice, Inbred SENCAR; Microsomes, Liver; Phenobarbital; Plant Extracts; Radioligand Assay | 1996 |
Development of a quantitative bioassay to assess preventive compounds against inflammation-based carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Biological Assay; Cell Adhesion; Coumarins; Endothelial Cells; Female; Fibrosarcoma; Fluorescence; Immunohistochemistry; Inflammation; Ketones; Methylcholanthrene; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Plant Oils; Sesquiterpenes; Toluene; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2011 |