Compounds > 3-methylcholanthrene

3-methylcholanthrene and rifampin

3-methylcholanthrene has been researched along with rifampin in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19904 (15.38)18.7374
1990's6 (23.08)18.2507
2000's10 (38.46)29.6817
2010's6 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erdmann, F; Fischer, G; Harris, R; Hopkins, S; Huang, Z; Murray, MG; Ribeill, Y; Scorneaux, B; Smitley, C; Wring, S1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Carazo, A; Drechslerová, M; Hrušková, ZR; Hyrsova, L; Kuneš, J; Nova, A; Pavek, P; Pour, M; Smutny, T; Špulák, M1
Bishai, WR; Guo, H; Kozikowski, AP; Lun, S; Merenbloom, B; Onajole, OK; Stec, J; Vistoli, G1
Heubel, F; Netter, KJ1
Bories, P; Daujat, M; Diaz, D; Fabre, I; Maurel, P; Michel, H; Saint Aubert, B1
Beaune, PH; Flinois, JP; Guengerich, FP; Guillouzo, A; Morel, F; Ratanasavanh, D; Yang, CS1
Gláz, ET1
Borisova, LN; Kovalev, IE1
Goerz, G; Ruzicka, T; Vizethum, W1
Beaune, P; Becquemont, L; Coles, B; Guengerich, FP; Guillouzo, A; Ketterer, B; Langouët, S; Morel, F1
Jacqueson, A; Nicod, L; Regnier, A; Richert, L; Viollon, C1
Li, AP; Masubuchi, N; Okazaki, O1
Fukuhara, M; Isozaki, E; Kurose, K; Tohkin, M1
Endo, Y; Honma, R; Jarukamjorn, K; Kuroiwa, M; Nemoto, N; Ohara, A; Sakuma, T; Takai, M1
Fleig, WE; Jäger, D; Köhler, C; Kostrubsky, VE; Lehmann, T; May, U; Michalopoulos, GK; Runge, D; Runge, DM; Stolz, DB; Strom, SC1
Jemnitz, K; Lengyel, G; Vereczkey, L1
Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E1
Castell, JV; Donato, MT; Gómez-Lechón, MJ; Klocke, R; Paul, D; Stenzel, K1
Asahara, T; Asahina, K; Furukawa, T; Hino, H; Kataoka, M; Saito, N; Soeno, Y; Tachibana, A; Tateno, C; Utoh, R; Yamasaki, C; Yokoi, T; Yoshizane, Y; Yoshizato, K1
Bratton, S; Finel, M; Gardner-Stephen, D; Li, X; Mackenzie, PI; Radominska-Pandya, A1
Bratton, S; Li, X; Radominska-Pandya, A1
Dial, S; Guo, L; Ning, B; Sun, Y; Wang, J; Yang, J1
Castell, JV; Donato, MT; Gómez-Lechón, MJ; Lahoz, A; Picazo, L1
Ishida, Y; Kakuni, M; Tachibana, A; Tateno, C; Yamasaki, C; Yoshizane, Y1

Other Studies

26 other study(ies) available for 3-methylcholanthrene and rifampin

ArticleYear
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:2

    Topics: Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cyclophilin A; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Haplorhini; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukocytes, Mononuclear; Mice; Molecular Structure; Rats; RNA, Viral; Virus Replication

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists.
    Journal of medicinal chemistry, 2016, 05-26, Volume: 59, Issue:10

    Topics: Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hep G2 Cells; Hepatocytes; Humans; Models, Molecular; Molecular Structure; Quinazolines; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship

2016
Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.
    Journal of medicinal chemistry, 2016, 07-14, Volume: 59, Issue:13

    Topics: Animals; Antitubercular Agents; Bacterial Proteins; Disease Models, Animal; Drug Design; Female; Humans; Indoles; Membrane Transport Proteins; Mice, Inbred BALB C; Microbial Sensitivity Tests; Models, Molecular; Molecular Docking Simulation; Molecular Targeted Therapy; Mycobacterium tuberculosis; Tuberculosis; Tuberculosis, Multidrug-Resistant

2016
Atypical inductive properties of rifampicin.
    Biochemical pharmacology, 1979, Dec-01, Volume: 28, Issue:23

    Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rifampin; Sleep; Time Factors

1979
Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.
    Gastroenterology, 1990, Volume: 99, Issue:3

    Topics: Aged; Benzoflavones; beta-Naphthoflavone; Blotting, Northern; Blotting, Western; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; Humans; In Vitro Techniques; Liver; Male; Methylcholanthrene; Middle Aged; Omeprazole; Oxygenases; Rifampin; RNA, Messenger

1990
Expression of cytochrome P-450 enzymes in cultured human hepatocytes.
    European journal of biochemistry, 1990, Jul-31, Volume: 191, Issue:2

    Topics: Adult; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Immunoenzyme Techniques; Infant, Newborn; Isoenzymes; Liver; Methylcholanthrene; Phenobarbital; Rifampin; RNA, Messenger

1990
Letter: Rifampicin in co-oncogenic experiments.
    Lancet (London, England), 1974, Aug-17, Volume: 2, Issue:7877

    Topics: Animals; Drug Synergism; Injections, Subcutaneous; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neoplasms, Experimental; Rifampin; Time Factors

1974
[Effect of inducers of mixed-function microsomal oxidases on the immune response of mice induced by heterologous erythrocytes].
    Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1981, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Antibody Formation; Benzodiazepines; Benzodiazepinones; Cytochrome P-450 Enzyme System; DDT; Diazepam; Enzyme Induction; Erythrocytes; Male; Methylcholanthrene; Mice; Phenobarbital; Phenytoin; Rifampin; Sheep

1981
Inducibility of drug-metabolizing enzymes in the rat skin.
    Chemico-biological interactions, 1980, Volume: 31, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rifampin; Skin

1980
Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.
    Cancer research, 1995, Dec-01, Volume: 55, Issue:23

    Topics: Aflatoxin B1; Aged; Anticarcinogenic Agents; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Female; Glutathione Transferase; Humans; Infant; Liver; Male; Methylcholanthrene; Middle Aged; Mixed Function Oxygenases; Oxidoreductases; Pyrazines; Rifampin; Thiones; Thiophenes; Time Factors

1995
Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells.
    Human & experimental toxicology, 1997, Volume: 16, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Carcinoma, Hepatocellular; Cell Survival; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Humans; Isoniazid; Liver Neoplasms; Methylcholanthrene; Rifampin; Tumor Cells, Cultured

1997
An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes.
    Chemico-biological interactions, 1998, Jul-03, Volume: 114, Issue:1-2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Benzimidazoles; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Lansoprazole; Liver; Male; Methylcholanthrene; Middle Aged; Omeprazole; Pantoprazole; Rifampin; Steroid Hydroxylases; Structure-Activity Relationship; Sulfoxides

1998
Cloning and expression analysis of a new member of the cytochrome P450, CYP2A15 from the Chinese hamster, encoding testosterone 7alpha-hydroxylase.
    Archives of biochemistry and biophysics, 1999, Nov-15, Volume: 371, Issue:2

    Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cloning, Molecular; Cricetinae; Cytochrome P-450 Enzyme System; DNA, Complementary; Female; Gene Expression; Hydroxylation; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes; Molecular Sequence Data; Phenobarbital; Phylogeny; Recombinant Proteins; Rifampin; Steroid Hydroxylases; Testosterone; Tissue Distribution

1999
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
    Archives of biochemistry and biophysics, 2000, May-01, Volume: 377, Issue:1

    Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Castration; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Liver; Male; Membrane Proteins; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; RNA, Messenger; Sex Characteristics; Sexual Maturation; Testosterone

2000
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
    Biochemical and biophysical research communications, 2000, Jun-24, Volume: 273, Issue:1

    Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; beta-Naphthoflavone; Blotting, Western; Cell Size; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Isoenzymes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenobarbital; Rifampin; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Vault Ribonucleoprotein Particles

2000
In vitro induction of bilirubin conjugation in primary rat hepatocyte culture.
    Biochemical and biophysical research communications, 2002, Feb-15, Volume: 291, Issue:1

    Topics: Animals; Bilirubin; Cells, Cultured; Clofibrate; Dexamethasone; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glucocorticoids; Glucuronosyltransferase; Hepatocytes; Hypolipidemic Agents; Immunoblotting; Isoenzymes; Male; Methylcholanthrene; Rats; Rats, Wistar; Rifampin

2002
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
    Archives of biochemistry and biophysics, 2002, Jun-01, Volume: 402, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E

2002
Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice.
    Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:5

    Topics: Animals; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Gene Expression; Hepatocytes; Hydroxylation; Liver; Methylcholanthrene; Mice; Mice, Transgenic; Phenobarbital; Rifampin; RNA, Messenger; Testosterone; Transcription Factors

2003
Near completely humanized liver in mice shows human-type metabolic responses to drugs.
    The American journal of pathology, 2004, Volume: 165, Issue:3

    Topics: Adolescent; Adult; Albumins; Animals; Child; Chimera; Complement C3-C5 Convertases; Complement C3a; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Hepatocytes; Heterozygote; Homozygote; Humans; In Situ Hybridization; Liver; Liver Failure; Male; Methylcholanthrene; Mice; Mice, SCID; Mice, Transgenic; Middle Aged; Rifampin; RNA, Messenger; Transplantation, Heterologous; Urokinase-Type Plasminogen Activator

2004
Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:3

    Topics: Adult; Aged; Amino Acid Sequence; Animals; Baculoviridae; Caco-2 Cells; Carcinoma, Hepatocellular; Catalysis; Cell Line, Tumor; Cells, Cultured; DNA, Complementary; Gene Expression; Glucuronosyltransferase; Hepatocytes; Humans; Insecta; Intestinal Mucosa; Isoenzymes; Liver Neoplasms; Male; Methylcholanthrene; Middle Aged; Molecular Sequence Data; Recombinant Proteins; Rifampin; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity

2005
Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes.
    Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:3

    Topics: Adult; Aged; Base Sequence; Cells, Cultured; Child, Preschool; Female; Gastrointestinal Tract; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hepatocytes; Humans; Intestinal Mucosa; Isoenzymes; Male; Methylcholanthrene; Middle Aged; Molecular Sequence Data; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sequence Homology, Nucleic Acid; UDP-Glucuronosyltransferase 1A9; Up-Regulation

2007
Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes.
    Journal of biomolecular screening, 2008, Volume: 13, Issue:3

    Topics: Brain; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Humans; Inactivation, Metabolic; Methylcholanthrene; Omeprazole; Polymerase Chain Reaction; Principal Component Analysis; Rifampin; RNA

2008
Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.
    Drug metabolism letters, 2008, Volume: 2, Issue:3

    Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Reproducibility of Results; Rifampin; Tandem Mass Spectrometry

2008
Chimeric mice with humanized livers: a unique tool for in vivo and in vitro enzyme induction studies.
    International journal of molecular sciences, 2013, Dec-20, Volume: 15, Issue:1

    Topics: Animals; Chimera; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Enzyme Induction; Half-Life; Hepatocytes; Humans; Immunohistochemistry; Keratin-18; Keratin-8; Liver; Methylcholanthrene; Mice; Rifampin; RNA, Messenger

2013