3-methylcholanthrene has been researched along with proadifen in 129 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 115 (89.15) | 18.7374 |
| 1990's | 9 (6.98) | 18.2507 |
| 2000's | 5 (3.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M | 1 |
| Castro, JA; Diaz Gomez, MI | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Kawalek, JC; Lu, AY | 1 |
| Belitskiĭ, GA; Bukhman, VM; Konopleva, IA | 1 |
| Gram, TE; Litterst, CL; Mimnaugh, EG | 1 |
| Ahokas, JT; Kärki, NT; Pelkonen, O | 1 |
| Bridges, JW; Chakraborty, J; Shirkey, RS | 1 |
| Ellis, S; Gill, DP; Kempen, RR; Nash, JB | 1 |
| Bellward, GD; Gontovnick, LS; Ng, S | 1 |
| Campbell, RL; Hettrick, JM; Nigro, ND; Suppnick, JD | 1 |
| Banerjee, S; Conney, AH; Kuntzman, R; Levin, W; Somogyi, A | 1 |
| Parke, DV | 1 |
| Capdevila, J; Helia, O; Jakobsson, SW; Jernström, B; Orrenius, S | 1 |
| David, JC | 1 |
| McDevitt, DG; Nies, AS; Rush, BD; Strother, JR; Wilkinson, GR | 1 |
| McDonagh, AF; Schmid, R | 1 |
| Frantz, CN; Malling, HV | 1 |
| Capdevila, J; Moldéus, P; Orrenius, S; Vadi, H | 1 |
| Belpaire, FM; Bogaert, MG | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Drew, RT; Fouts, JR; Lo, RJ; Roth, RP | 1 |
| Gangolli, SD; Heading, CE; Lake, BG; Lloyd, AG; Phillips, JC | 1 |
| Lohmann, SM; Miech, RP | 1 |
| Couture, J; Dahlström-King, L; Plaa, GL | 1 |
| Schröder, H | 1 |
| Giri, SN; Siegel, DM | 1 |
| Castonguay, A; Charest, M; Rossignol, G | 1 |
| Berndt, WO; Christenson, WR; Davis, ME | 1 |
| Marselos, M; Vasiliou, V | 1 |
| Bender, PE; Eckardt, RD; Leonard, TB; Newton, JF; Romano, MC; Straub, KM | 1 |
| Hayashi, S; Ishikawa, T; Murakami, K; Noshiro, M; Okuda, K; Shimosato, T | 1 |
| Abraham, NG; Mullane, KM; Pinto, A | 2 |
| Furukawa, N; Sato, M; Suzuki, Y | 1 |
| Kuroiwa, Y; Yamada, Y; Yamamoto, T; Yoshida, T | 1 |
| Kuroiwa, Y; Oguro, T; Yoshida, T | 1 |
| Duddy, SK; Hsia, MT | 1 |
| Blakey, DC; White, IN | 1 |
| Smith, AG; Stewart, FP | 1 |
| Gram, TE; Okine, LK | 1 |
| Forkert, PG; Racz, WJ; Stringer, V | 1 |
| Gad-El Karim, MM; Legator, MS; Sadagopa Ramanujam, VM | 1 |
| Borrello, S; Galeotti, T; Minotti, G; Palombini, G | 1 |
| Burke, MD; Elcombe, CR; Haaparanta, T; Halpert, J; Mayer, RT; Thompson, S | 1 |
| Kuwahara, S; Mannering, GJ | 1 |
| Kim, HL | 1 |
| Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A | 2 |
| Van Dyke, RA; Wood, CL | 1 |
| Correia, MA; Mannering, GJ | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Kato, R | 1 |
| Burgison, RM; Dietz, AJ | 1 |
| Kato, R; Omori, Y; Takanaka, A | 1 |
| Carlson, GP; Fuller, GC | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 1 |
| Brodeur, J; Gascon, AL | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 2 |
| Kataoka, S; Takabatake, E | 1 |
| Rabin, BR; Williams, DJ | 1 |
| Mazel, P; Shargel, L | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, SB | 1 |
| Gillette, JR | 1 |
| Fang, VS; Tashjian, AH | 1 |
| Ikeda, M; Imamura, T; Otsuji, H | 1 |
| Moroi, K; Sato, T | 1 |
| Castro, JA; D'Acosta, N; de Castro, CR; de Ferreyra, EC; Díaz Gómez, MI | 1 |
| Gillette, JR; Hamrick, M; Jollow, DJ; Mitchell, JR; Stripp, B; Zampaglione, N | 1 |
| Back, KC; Murphy, JP; Van Stee, EW | 1 |
| Frommer, U; Ullrich, V; Weber, P | 1 |
| Gustafsson, JA; Ingelman-Sundberg, M | 1 |
| Levine, WG | 1 |
| Prabhu, VG | 1 |
| Kato, R; Oshima, T; Takayanagi, M | 1 |
| Aebi, H; Baggiolini, M; Dewald, B | 2 |
| Alvares, AP; Mannering, GJ | 1 |
| Aust, SD; Pederson, TC | 1 |
| Weisburger, EK; Weisburger, JH; Yamamoto, RS | 1 |
| Wheatley, DN | 1 |
| Nery, R | 1 |
| Mannering, GJ; Sladek, NE | 1 |
| Anders, MW; Furner, RL; McCarthy, JS; Stitzel, RE | 1 |
| Burns, JJ; Conney, AH; Koster, R; Sansur, M; Soroko, F | 1 |
| Blake, DA; Cascorbi, HF; Krantz, JC; Rozman, RS | 1 |
| Gad-El-Karim, MM; Harper, BL; Legator, MS | 1 |
| Nagata, K; Yoshihara, S; Yoshimura, H | 1 |
| Cameron, RC; Farber, E; Hayes, MA; Jago, MV; Roberts, E; Safe, SH | 1 |
| Bahnson, LS; Buckpitt, AR; Franklin, RB | 1 |
| Khera, KS | 1 |
| Chakrabarti, S; Law, FC | 1 |
| Bryan, AH; Greiner, JW; Janss, DH; Malan-Shibley, LB | 1 |
| Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT | 1 |
| DePierre, JW; Meijer, J | 1 |
| Breeze, RG; Carlson, JR; Leung, CT | 1 |
| Belitskiĭ, GA; Kiseleva, MG; Prikhod'ko, AZ | 1 |
| Mannering, GJ; Schwen, RJ | 1 |
| Breger, RK; Franklin, RB; Griffin, KA; Johnson, CB | 1 |
| Little, PJ; Ryan, AJ | 1 |
| Bellward, GD; Gontovnick, LS | 1 |
| Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
| Inoue, T; Murata, T; Niwaguchi, T | 1 |
| Kitagawa, H; Naminohira, S; Saito, H; Sakai, T; Ueno, K | 1 |
| Grafstöm, R; Stohs, SJ | 1 |
| Iverson, F; Khera, KS | 1 |
| Brodeur, J; Chakrabarti, S | 1 |
| Berg, IE; Chaturvedi, AK; Rao, NG | 1 |
| Dent, JG; Sun, JD | 1 |
| Chan, PK; Hayes, AW; Reddy, CS | 1 |
| Hollenberg, PF; Koop, DR | 1 |
| Anders, MW; Ratnayake, JH; Stevens, JL | 1 |
| Raffali, F; Roguet, R; Rougier, A | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Greenblatt, DJ; LeDuc, BW; Shuster, L; Sinclair, JF; Sinclair, PR; Walton, HS | 1 |
| Burrows, GE; Eissa, FZ; Lish, JW; Qualls, CW | 1 |
| Choi, YJ; Kim, WB; Kwon, JW; Lee, HJ; Lee, MG; Yang, J | 1 |
| Abdel-Aziz, AH; Abdel-Naim, AB; Abo-Salem, O; Hamada, FM; Mostafa, AM | 1 |
| Hurh, E; Kim, S; Kim, Y; Lee, A; Lee, E; Lee, M | 1 |
| Ariyama, J; Furuno, H; Hirai, K; Koyama, J; Shimada, H; Simamura, E | 1 |
| MORELLO, A | 1 |
| CONNEY, AH; JACOBSON, M; KUNTZMAN, R; SCHNEIDMAN, K | 1 |
| BLEIBERG, MJ; JOHNSON, H | 1 |
| Bae, SK; Lee, DY; Lee, MG; Shin, HS | 1 |
| Bae, SK; Choi, YH; Kim, SO; Lee, MG | 1 |
| Choi, YH; Lee, JH; Lee, MG; Lee, U; Yang, KH | 1 |
3 review(s) available for 3-methylcholanthrene and proadifen
| Article | Year |
|---|---|
Induction of the drug-metabolizing enzymes.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Barbiturates; Benzopyrene Hydroxylase; Benzopyrenes; Cytochrome P-450 Enzyme System; Diet; Endoplasmic Reticulum; Enzyme Induction; Female; Glucuronosyltransferase; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pregnancy; Proadifen; Protein Biosynthesis; Rats; Species Specificity; Transcription, Genetic | 1975 |
The enzymatic formation of bilirubin.
Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen | 1975 |
Sex-related differences in drug metabolism.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Estradiol; Female; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Pentobarbital; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Proadifen; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet; Strychnine; Testosterone | 1974 |
126 other study(ies) available for 3-methylcholanthrene and proadifen
| Article | Year |
|---|---|
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes | 1976 |
Further studies on the mechanism of the carbon tetrachloride induced polysome breakdown.
Topics: Age Factors; Amitrole; Animals; Carbon Tetrachloride; Cycloheximide; In Vitro Techniques; Liver; Male; Malonates; Methylcholanthrene; Mice; Mice, Inbred A; Niacinamide; Phenobarbital; Polyribosomes; Proadifen; Pyrazoles; Rats | 1976 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome Reductases; Cytochromes; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Pharmaceutical Preparations; Proadifen; Rabbits; Rats | 1975 |
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Methylcholanthrene; Mice; Microsomes; Oxidoreductases; Phenobarbital; Premedication; Proadifen; Rauscher Virus; Spleen; Tegafur | 1979 |
Comparative alterations in extrahepatic drug metabolism by factors known to affect hepatic activity.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Rabbits; Rats; Starvation | 1977 |
Characterization of benzo(a)pyrene hydroxylase of trout liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Proadifen; Rats; Salmonidae; Trout | 1977 |
Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1979 |
Modifications of benzene myelotoxicity and metabolism by phenobarbital, SKF-525A and 3-methylcholanthrene.
Topics: Animals; Benzene; Leukocytosis; Leukopenia; Male; Methylcholanthrene; Phenobarbital; Phenols; Proadifen; Rats | 1979 |
The irreversible binding of benzo[a]pyrene to rat liver macromolecules in vivo and in vitro: effects of agents that influence benzo[a]pyrene metabolism.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cysteine; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione; In Vitro Techniques; Liver; Male; Methadone; Methylcholanthrene; Nucleic Acids; Proadifen; Protein Binding; Rats; Time Factors | 1979 |
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Benzoflavones; Biotransformation; Chlorides; Cobalt; Diet; Disulfiram; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats | 1978 |
Inhibition of the acute toxicity and adrenocorticolytic effect of 7,12-dimethylbenz(a)anthracene by isopropylvaleramide and allylisopropylacetamide in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetamides; Adrenal Cortex; Adrenal Glands; Allylisopropylacetamide; Amides; Animals; Barbiturates; Benz(a)Anthracenes; Benzopyrenes; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Methylcholanthrene; Pentobarbital; Phenobarbital; Proadifen; Rats; Secobarbital; Time Factors; Valerates | 1975 |
Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration.
Topics: Animals; Cell Fractionation; Chromatography, Agarose; Cytochrome P-450 Enzyme System; Cytochromes; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Rats; Spectrum Analysis; Stimulation, Chemical; Ultracentrifugation | 1975 |
Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system.
Topics: Animals; Benserazide; Biotransformation; Cobalt; Cysteine; Glutathione; Humans; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Tyrosine | 1976 |
Effects of alteration of hepatic microsomal enzyme activity on liver blood flow in the rat.
Topics: Animals; Benzopyrenes; Cardiac Output; Enzyme Induction; Hemodynamics; Liver Circulation; Male; Methylcholanthrene; Microsomes, Liver; Microspheres; Phenobarbital; Proadifen; Rats; Zoxazolamine | 1976 |
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Histidine; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Proadifen; Salmonella typhimurium; Time Factors; Valerates | 1975 |
The metabolism of benzo(alpha)pyrene in isolated rat liver cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Cells, Cultured; Flavonoids; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rotenone; Solubility; Stimulation, Chemical | 1975 |
Metabolism of papaverine. III. Effect of phenobarbital, 3-methylcholanthrene and SKF 525-A pre-treated in vivo and in vitro.
Topics: Aminopyrine N-Demethylase; Animals; Bile; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases, O-Demethylating; Papaverine; Phenobarbital; Proadifen; Rats | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.
Topics: Animals; Carbon Tetrachloride; Carboxyhemoglobin; Hemoglobins; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rabbits | 1975 |
Studies on the metabolism of dimethylnitrosamine in the rat. II. The effects of phenobarbitone and 20-methylcholanthrene on the in vitro and in vivo metabolism and acute toxicity of dimethylnitrosamine in young and mature rats.
Topics: Age Factors; Aminopyrine; Aniline Hydroxylase; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sex Factors | 1975 |
Theophylline metabolism by the rat liver microsomal system.
Topics: Aldehyde Oxidoreductases; Animals; Cytosol; Female; Half-Life; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Proadifen; Rats; Theophylline; Time Factors; Xanthine Oxidase | 1976 |
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ketones; Liver; Male; Methylcholanthrene; Mirex; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Sprague-Dawley; Taurolithocholic Acid | 1992 |
Cytochrome P-450 mediates bioactivation of organic nitrates.
Topics: Animals; Cell Line; Cells, Cultured; Cyclic GMP; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fibroblasts; Guanylate Cyclase; Liver; Lung; Male; Methylcholanthrene; Nitroglycerin; Proadifen; Rats; Rats, Inbred Strains | 1992 |
Characterization of covalent binding of [14C]-2-chloro-4-acetotoluidide to microsomes of starling liver and kidney.
Topics: Animals; Benzoflavones; Birds; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Glutathione; In Vitro Techniques; Kidney; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Protein Binding; Sulfhydryl Compounds; Toluidines | 1991 |
In vitro and in vivo modulation of the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in hamster lung tissues.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Cricetinae; Kinetics; Lung; Male; Mesocricetus; Methylcholanthrene; Nitrosamines; Organ Culture Techniques; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Proteins; Reference Values | 1989 |
Effect in the rat of the interaction of dichloromaleic acid and carbon tetrachloride on renal and hepatic function.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Drinking; Female; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Maleates; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Water Pollutants; Water Pollutants, Chemical | 1989 |
Changes in the inducibility of a hepatic aldehyde dehydrogenase by various effectors.
Topics: Aldehyde Dehydrogenase; Animals; Cyanamide; Disulfiram; Enzyme Induction; Isoenzymes; Male; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1989 |
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature | 1987 |
Aryl hydrocarbon hydroxylase activity in rat submandibular glands.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Carbon Monoxide; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Oxygenases; Proadifen; Rats; Rats, Inbred Strains; Submandibular Gland; Time Factors | 1986 |
Cytochrome P-450-dependent monooxygenase activity and endothelial-dependent relaxations induced by arachidonic acid.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Blood Vessels; Cobalt; Cytochrome P-450 Enzyme System; Drug Synergism; Endothelium; Fatty Acids; Indomethacin; Male; Methylcholanthrene; Oxygenases; Phenylephrine; Proadifen; Pulmonary Artery; Pyrazoles; Rabbits; Vasoconstriction; Vasodilation | 1986 |
Effects of alkyl phosphorothioates on the hepatic microsomal mixed-function oxidase system in rats. Inhibition of drug-metabolizing enzyme activity and selective increase of NADPH-cytochrome c reductase activity.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organothiophosphorus Compounds; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency.
Topics: Amphetamine; Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxylation; In Vitro Techniques; Male; Methamphetamine; Methimazole; Methylcholanthrene; Microsomes, Liver; Monoamine Oxidase Inhibitors; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline | 1986 |
Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Benzoflavones; beta-Naphthoflavone; Coronary Vessels; Cytochrome P-450 Enzyme System; Dinoprost; Dogs; Endothelium; In Vitro Techniques; Indomethacin; Male; Methylcholanthrene; Muscle Contraction; Muscle Relaxation; Proadifen; Prostaglandins F | 1987 |
Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences.
Topics: Amphetamines; Animals; Chromatography, Gas; Female; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline; Sex Factors; Species Specificity | 1987 |
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and Drug Induced Liver Injury; Cimetidine; Dose-Response Relationship, Drug; Insecticides; Male; Methylcholanthrene; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Plants; Proadifen; Rats; Rats, Inbred Strains | 1987 |
Destruction of cytochrome P-450 and formation of green pigments by contraceptive steroids in rat hepatocyte suspensions.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Humans; Liver; Male; Methylcholanthrene; Norethindrone; Phenobarbital; Pigments, Biological; Proadifen; Rats; Rats, Inbred F344; Steroids; Structure-Activity Relationship; Suspensions; Time Factors | 1986 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice.
Topics: Animals; Bronchi; Dichloroethylenes; Drug Interactions; Hydrocarbons, Chlorinated; Lung; Male; Methylcholanthrene; Mice; Microsomes; Necrosis; Piperonyl Butoxide; Proadifen; Time Factors | 1986 |
Correlation between the induction of micronuclei in bone marrow by benzene exposure and the excretion of metabolites in urine of CD-1 mice.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Bone Marrow; Catechols; Cell Nucleus; Chromosome Aberrations; Female; Hydroquinones; Male; Methylcholanthrene; Mice; Mutagenicity Tests; Phenol; Phenols; Proadifen; Toluene | 1986 |
Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochromes; Ethylmorphine; Hydrogen Peroxide; Kinetics; Lipid Peroxides; Liver Neoplasms, Experimental; Methylcholanthrene; Microsomes; Microsomes, Liver; Proadifen; Progesterone; Rats; Rats, Inbred BUF | 1986 |
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate.
Topics: Animals; Disulfiram; Ethoxyquin; Glutathione; Inactivation, Metabolic; Lethal Dose 50; Lobeline; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Proadifen | 1985 |
Relation between hepatic microsomal metabolism of N-nitrosamines and cytochrome P-450 species.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1985 |
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats | 1973 |
Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Codeine; Cyanides; Cytochrome P-450 Enzyme System; Drug Synergism; Female; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; NAD; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Phospholipases; Proadifen; Protein Binding; Rats | 1973 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
The biotransformation of 8-ethylthio-6-thiotheophylline sodium in vivo.
Topics: Amines; Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Dactinomycin; Depression, Chemical; Hypnotics and Sedatives; Male; Methylcholanthrene; Oils; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical; Theophylline; Time Factors | 1968 |
Factors affecting the toxicity and metabolism of OMPA (octamethylpyrophosphoramide) in rats.
Topics: Age Factors; Animals; Butylene Glycols; Chlorpromazine; Cholinesterase Inhibitors; Cholinesterases; Diphosphates; Ethionine; Female; Glutethimide; Insecticides; Liver; Male; Meprobamate; Methylcholanthrene; Microsomes; Pentobarbital; Phenobarbital; Proadifen; Rats | 1967 |
Interaction of modifiers of hepatic microsomal drug metabolism and the inhalation toxicity of 1,1-dichloroethylene.
Topics: Aerosols; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chlorine; Chromatography, Gas; Drug Interactions; Ethylamines; Glucose-6-Phosphatase; Hydrocarbons, Halogenated; Lung; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Proadifen; Rats; Time Factors | 1972 |
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Sex Factors; Spectrophotometry; Time Factors; Valerates | 1969 |
Influence of microsomal enzyme inducers on the reactivity of the isolated guinea pig seminal vesicle to angiotensin and tyramine.
Topics: Angiotensin II; Animals; Aspirin; Dactinomycin; DDT; Drug Antagonism; Enzyme Induction; Glutethimide; Guinea Pigs; Male; Meprobamate; Methylcholanthrene; Microsomes; Phenobarbital; Piperazines; Proadifen; Protein Biosynthesis; Seminal Vesicles; Sulfanilamides; Tyramine | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Comparative N-demethylation of antihistaminic agents possessing dimethylaminoalkyl group by liver preparations from four animal species.
Topics: Age Factors; Animals; Castration; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Histamine H1 Antagonists; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Rabbits; Rats; Sex Factors; Species Specificity; Testosterone | 1971 |
Distruption by carcinogens of the hormone dependent association of membranes with polysomes.
Topics: Animals; Carcinogens; Endoplasmic Reticulum; Enzyme Activation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; p-Dimethylaminoazobenzene; Proadifen; Rats; Ribosomes; RNA; Sulfides | 1971 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
Topics: Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Flavonoids; Hemeproteins; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital; Piperazines; Proadifen; Rats; Structure-Activity Relationship; Testosterone | 1973 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; Enzymes; Glucuronates; Glutathione; Half-Life; Intestinal Absorption; Kidney; Kinetics; Liver Diseases; Metabolism; Methylcholanthrene; Mice; Models, Theoretical; Necrosis; Phenobarbital; Proadifen; Rats; Regional Blood Flow; Sulfates; Toxicology | 1974 |
Studies on the role of the liver in the metabolism of parathyroid hormone. I. Effects of partial hepatectomy and incubation of the hormone with tissue homogenates.
Topics: Adrenal Glands; Adrenalectomy; Animals; Antigens; Aprotinin; Calcium; Culture Techniques; Female; Hemorrhage; Hepatectomy; Hydrocortisone; Kidney; Liver; Male; Methylcholanthrene; Nephrectomy; Parathyroid Glands; Parathyroid Hormone; Phenobarbital; Phosphorus; Proadifen; Radioimmunoassay; Rats; Spleen | 1972 |
Comparative studies on hepatic N- and O-demethylation.
Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide | 1972 |
Species differences in induction and inhibition of liver isocarboxazid hydrolase.
Topics: Aging; Animals; Animals, Newborn; Enzyme Induction; Female; Guinea Pigs; Hydrolases; In Vitro Techniques; Isocarboxazid; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Pregnancy; Proadifen; Rabbits; Rats; Species Specificity | 1973 |
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Proadifen; Protein Binding; Pyrazoles; Rats; Sex Factors; Statistics as Topic | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Drug Antagonism; Half-Life; Hydrocarbons, Brominated; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Necrosis; Phenobarbital; Proadifen; Rats; Time Factors | 1973 |
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Paralysis; Phenobarbital; Proadifen; Respiration; Sleep; Time Factors; Zoxazolamine | 1973 |
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics.
Topics: Age Factors; Androstanes; Animals; Carbon Monoxide; Carbon Radioisotopes; Castration; Estradiol; Female; Hydroxysteroids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Sex Factors; Steroid Hydroxylases; Sulfuric Acids; Testosterone | 1974 |
Biliary excretion of 3-methylcholanthrene as controlled by its metabolism.
Topics: Animals; Benzopyrenes; Bile; Depression, Chemical; Enzyme Induction; Female; Half-Life; Injections, Intravenous; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Stimulation, Chemical; Time Factors; Tritium | 1972 |
The effect of microsomal enzyme stimulants and depressants on amphetamine aggregation toxicity in mice.
Topics: Amphetamine; Animals; Benzopyrenes; Carbon Tetrachloride; Chlordan; Enzyme Repression; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Proadifen | 1969 |
Differences in the oxidative metabolism of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Oxidoreductases; Pentobarbital; Phenobarbital; Proadifen; Rats; Sex Factors; Starvation; Thyroxine; Zoxazolamine | 1969 |
N-demethylation of p-(N1-methylhydrazion methyl)-N-isopropyl benzamide (procarbazine), a cytostatically active methylhydrazine derivative, in the intact rat and in the isolated perfused rat liver.
Topics: Animals; Benzoates; Carbon Dioxide; Carbon Isotopes; Hydrazines; Liver; Male; Methylation; Methylcholanthrene; Oxidation-Reduction; Perfusion; Phenobarbital; Proadifen; Rats | 1969 |
Oxidation of p-(N1-methylhydrazino methyl)-N-isopropyl benzamide (procarbazine) to the methylazo derivative and oxidative cleavage of the N2-C bond in the isolated perfused rat liver.
Topics: Anilides; Animals; Azo Compounds; Benzoates; Carbon Isotopes; Hydrazines; Imines; Liver; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Perfusion; Proadifen; Rats; Spectrophotometry | 1969 |
Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes.
Topics: Alkylation; Aniline Compounds; Animals; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Stereoisomerism | 1970 |
Further evidene on the nature of microsomal metabolism of procarbazine and related alkyhydrazines.
Topics: Animals; Benzoates; Carbon Monoxide; Cytochromes; Enzyme Induction; Hydrazines; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen; Oxidoreductases; Oxygen; Phenobarbital; Proadifen; Rats; Sheep; Swine; Trypsin | 1970 |
Aminopyrine demethylase. Kinetic evidence for multiple microsomal activities.
Topics: Aminopyrine; Animals; Carbon Monoxide; Chromatography, Thin Layer; Cytochromes; Dealkylation; Enzyme Induction; Ethionine; Goats; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rats; Spectrophotometry; Stimulation, Chemical; Sulfites | 1970 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Phenothiazines; Proadifen; Puromycin; Urethane | 1971 |
Enhancement and inhibition of the induction by 7,12-dimethylbenz(a)anthracene of mammary tumours in female Sprague-Dawley rats.
Topics: Adenocarcinoma; Adenofibroma; Adenoma; Animals; Anthracenes; Benz(a)Anthracenes; Fibroma; Mammary Neoplasms, Experimental; Methylcholanthrene; Proadifen; Rats | 1968 |
Some aspects of the metabolism of urethane and N-hydroxyurethane in rodents.
Topics: Aging; Animals; Animals, Newborn; Carbamates; Chloromercuribenzoates; Cyanides; Depression, Chemical; Dinitrophenols; Female; Liver; Lung; Male; Methylcholanthrene; Mice; Microsomes; Models, Biological; Nitrites; Proadifen; Pyridoxal Phosphate; Quinones; Rats; Sex Factors; Stimulation, Chemical; Temperature; Time Factors; Urethane; Vanadium; Vitamin K | 1968 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
Stereoselective metabolism of the enantiomers of hexobarbital.
Topics: Animals; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Sleep; Stereoisomerism; Time Factors | 1969 |
Enzyme induction and inhibition in studies on the pharmacological actions of acetophenetidin.
Topics: Animals; Fever; In Vitro Techniques; Liver; Methylcholanthrene; Phenacetin; Proadifen; Rats | 1966 |
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Dactinomycin; Dogs; Ethers; Ethyl Ethers; Ethylamines; Female; Male; Methylcholanthrene; Mice; Nitrous Oxide; Phenobarbital; Proadifen | 1967 |
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.
Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine | 1984 |
Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A.
Topics: Animals; Aroclors; Benzene; Bone Marrow; Cell Nucleus; Chlorodiphenyl (54% Chlorine); Drug Interactions; Female; Male; Metaphase; Methylcholanthrene; Mice; Mutagenicity Tests; Mutagens; Mutation; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Sex Factors; Toluene | 1984 |
Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital-type and 3-methylcholanthrene-type polychlorinated biphenyls in rats.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes.
Topics: Animals; Carcinogens; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 1984 |
Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytosol; Epoxide Hydrolases; Glutathione; Glutathione Transferase; In Vitro Techniques; Lung; Male; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Naphthalenes; Phenobarbital; Piperonyl Butoxide; Proadifen; Proteins | 1984 |
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot Deformities, Congenital; Hindlimb; Imidazoles; Methylcholanthrene; Mice; Phenobarbital; Pregnancy; Proadifen; Species Specificity | 1984 |
Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.
Topics: Animals; Bile; Cyclohexanes; Enzyme Induction; Glutathione; Kinetics; Male; Maleates; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1984 |
Aryl hydrocarbon hydroxylase and epoxide hydratase activities: age effects in mammary epithelial cells of Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Enzyme Induction; Epithelium; Epoxide Hydrolases; Female; Liver; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylcholanthrene; Metyrapone; Polycyclic Compounds; Proadifen; Rats | 1980 |
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1980 |
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.
Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone | 1983 |
Effects of mixed-function oxidase inducers and inhibitors on cytochrome P-450 content, gel electrophoresis profiles, and 3-methylindole-induced lung toxicity in goats.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Goats; Indoles; Liver; Lung; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Proadifen; Skatole | 1983 |
[Cytochrome P-450 and aryl hydroxylase activity in cells of a long-term transplantable tumor].
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes; Neoplasm Transplantation; Neoplasms, Experimental; Oxygenases; Proadifen; Time Factors | 1983 |
Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake--III. Induction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rana pipiens; Salmonidae; Snakes; Species Specificity; Trout | 1982 |
Effects of inducers and inhibitors of cytochrome P-450-linked monooxygenases on the toxicity, in vitro metabolism and in vivo irreversible binding of 2-methylnaphthalene in mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Naphthalenes; Oxidoreductases; Phenobarbital; Piperonyl Butoxide; Proadifen | 1982 |
Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Enzyme Induction; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1982 |
Differential sensitivity of hepatic microsomal aryl hydrocarbon hydroxylase to the inhibitory effect of SKF 525-A in rats of varying age, hormonal- and drug-induced status.
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Disorders of Sex Development; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sex Factors | 1982 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
Effects of inducers and/or inhibitors on metabolism of lysergic acid diethylamide in rat liver microsomes.
Topics: Animals; Biotransformation; Carbon Monoxide; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Lysergic Acid Diethylamide; Methylcholanthrene; Microsomes, Liver; NAD; Oxygen Consumption; Phenobarbital; Proadifen; Rats | 1980 |
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; Male; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Pregnancy; Proadifen | 1981 |
Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells.
Topics: Animals; Benzoflavones; Benzopyrenes; Coumarins; Cytochrome P-450 CYP1A1; Female; Intestine, Small; Methylcholanthrene; Metyrapone; Microsomes; Oxidoreductases; Proadifen; Rats; Rats, Inbred Strains; Rotenone | 1981 |
Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethylenethiourea; Female; Imidazoles; Methylcholanthrene; Phenobarbital; Pregnancy; Proadifen; Rats; Teratogens; Time Factors | 1981 |
Effects of microsomal induction and inhibition on styrene-induced acute hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Serum Albumin; Styrenes; Sulfhydryl Compounds | 1981 |
The role of hepatic microsomal enzymes in the modulation of phencyclidine-induced toxicity.
Topics: Animals; Body Weight; Cysteine; Eating; Lethal Dose 50; Liver; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Pentobarbital; Phencyclidine; Phenobarbital; Proadifen | 1981 |
Development of a novel method for measuring covalent binding and its application to investigations of bromobenzene hepatotoxicity.
Topics: Animals; Biopolymers; Biotransformation; Bromobenzenes; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1981 |
Acute toxicity of penicillic acid and its interaction with pentobarbital and other compounds.
Topics: Animals; Body Temperature; Caproates; Cysteine; Drug Interactions; Lethal Dose 50; Male; Maleates; Methylcholanthrene; Mice; Penicillic Acid; Pentobarbital; Proadifen; Sleep; Time Factors | 1980 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Metabolism of dihalomethanes to carbon monoxide. IV. Studies in isolated rat hepatocytes.
Topics: Animals; Carbon Monoxide; Hydrocarbons, Halogenated; In Vitro Techniques; Kinetics; Liver; Male; Methane; Methylcholanthrene; Phenobarbital; Proadifen; Rats | 1980 |
Measurement and modulation of cytochrome-P450-dependent enzyme activity in cultured human keratinocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adult; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Female; Humans; Keratinocytes; Methylcholanthrene; Middle Aged; Oxidoreductases; Proadifen | 1994 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Cocaine; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunoblotting; L-Lactate Dehydrogenase; Liver; Methylcholanthrene; Models, Biological; Porphyrins; Proadifen; Protein Biosynthesis | 1994 |
Effects of feeding Artemisia filifolia and Helenium flexuosum on rabbit cytochrome P450 isozymes.
Topics: Animal Feed; Animals; Artemisia; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Plants, Medicinal; Plants, Toxic; Proadifen; Rabbits | 1996 |
Pharmacokinetic changes of M1, M2, M3 and M4 after intravenous administration of a new anthracycline, DA-125, to rats pretreated with phenobarbital, 3-methylcholanthrene, chloramphenicol, or SKF-525A.
Topics: Animals; Anthracyclines; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Carcinogens; Carotid Arteries; Chloramphenicol; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Injections, Intravenous; Jugular Veins; Male; Methylcholanthrene; Phenobarbital; Proadifen; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 1998 |
Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Topics: Acrylonitrile; Animals; Benzimidazoles; Cyanides; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Hydrogen-Ion Concentration; Kidney; Male; Methylcholanthrene; Microsomes; NADP; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfhydryl Compounds; Temperature | 1999 |
Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Insecticides; Isoenzymes; Isoniazid; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2000 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
ROLE OF DDT-HYDROXYLATION IN RESISTANCE.
Topics: Animals; DDT; Hydroxylation; Insect Vectors; Iproniazid; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Proadifen; Proteins; Research | 1964 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmacology; Phenobarbital; Proadifen; Rats; Research; Sex; Steroid Hydroxylases; Testosterone | 1964 |
EFFECTS OF CERTAIN METABOLICALLY ACTIVE DRUGS AND OXIMES ON TRI-O-CRESYL PHOSPHATE TOXICITY.
Topics: Animals; Antidotes; Atropine; Cholinesterases; Cresols; Dogs; Erythrocytes; Methylcholanthrene; Mice; Niacin; Niacinamide; Oximes; Pharmacology; Phosphates; Poultry; Pralidoxime Compounds; Proadifen; Research; Toxicology; Tritolyl Phosphates | 1965 |
Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous omeprazole in rats.
Topics: Animals; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Injections, Intravenous; Male; Methylcholanthrene; Microsomes, Liver; Omeprazole; Proadifen; Rats; Rats, Sprague-Dawley | 2006 |
Pharmacokinetics of 5-fluorouracil in mutant Nagase analbuminemic rats: faster metabolism of 5-fluorouracil via CYP1A.
Topics: Acetylglucosaminidase; Animals; Antimetabolites; Area Under Curve; Blood Proteins; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Enzyme Inhibitors; Fluorouracil; Half-Life; Injections, Intravenous; Male; Methylcholanthrene; Microdialysis; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Serum Albumin | 2007 |
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
Topics: Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cimetidine; Cytochrome P-450 Enzyme System; Diuretics; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Furosemide; Half-Life; Infusions, Intravenous; Injections, Intravenous; Isoniazid; Male; Methylcholanthrene; Orphenadrine; Proadifen; Quinine; Rats; Rats, Sprague-Dawley; Troleandomycin; Weight Gain | 2009 |