3-methylcholanthrene has been researched along with phenobarbital in 1495 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1241 (83.01) | 18.7374 |
| 1990's | 203 (13.58) | 18.2507 |
| 2000's | 45 (3.01) | 29.6817 |
| 2010's | 6 (0.40) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Erdmann, F; Fischer, G; Harris, R; Hopkins, S; Huang, Z; Murray, MG; Ribeill, Y; Scorneaux, B; Smitley, C; Wring, S | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Marniemi, J; Parkki, MG | 1 |
| Autrup, H; Thurlow, BJ; Warwick, GP | 1 |
| Autrup, H; Warwick, GP | 1 |
| Hildebraunt, AG; Roots, I | 1 |
| Mannering, GJ; Peisach, J | 1 |
| Bradshaw, JJ; Harrison, GG; Ivanetich, KM; Kaminsky, LS; Marsh, JA; Webber, BL | 1 |
| Bradshaw, JJ; Ivanetich, KM; Kaminsky, LS; Marsh, JA | 1 |
| Hunter, AL; Neal, RA | 1 |
| Uehleke, H; Werner, T | 1 |
| Shigematsu, H; Yamano, S; Yoshimura, H | 1 |
| Iwasaki, K; Kato, R; Sugiura, M | 2 |
| Bradshaw, JJ; Harrison, GG; Ivanetich, KM; Kaminsky, LS; Marsh, JA | 1 |
| Kahl, GF; Kahl, R; Kumaki, K; Nebert, DW | 1 |
| Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M | 1 |
| Conney, AH; Jerina, DM; Levin, W; Tomaszewski, JE | 1 |
| Elliott, JM; Idoine, JB; Weisburger, EK; Wilson, MJ | 1 |
| Beckett, AH; Coutts, RT; Dawson, GW | 1 |
| Michalopoulos, G; Pitot, HC; Sattler, C; Sattler, G | 1 |
| Cumps, J; Razzouk, C; Roberfroid, MB | 1 |
| Aronson, I; Ivanetich, KM; Katz, ID | 1 |
| Evans, JS; Gammans, RE; Sternson, LA; Wade, AE | 1 |
| Hinson, JA; Mitchell, JR; Nelson, SD | 1 |
| De Raat, WK | 1 |
| Rokuhara, M; Suzuki, K; Wada, F | 1 |
| Kumaki, K; Nebert, DW; Shichi, H | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 1 |
| Kennan, KA; Lin, JK; Miller, EC; Miller, JA | 1 |
| Aust, SD; Dannan, GA; Moore, RW | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 2 |
| Buhler, DR; Henderson, MC; Miller, A | 1 |
| Iamkovoĭ, VI; Liakhovich, VV; Pospelova, LN; Tsyrlov, IB; Vaĭner, LM | 1 |
| Parkinson, A; Safe, S | 3 |
| Dahms, RP; Gurtoo, HL | 1 |
| Arcos, JC; Argus, MF; Lai, DY | 2 |
| Kitagawa, Y; Kuroiwa, Y | 1 |
| Bernacki, RJ; Gurtoo, HL | 1 |
| Benoit, A; Chauveau, J; Decloître, F; Martin, M | 1 |
| Cavalier, R; Cumps, J; Toussaint, A | 1 |
| Decloitre, F; Mikol, YB | 1 |
| Cumps, J; Dumont, P; Luu-The, V; Vandresse, C | 2 |
| Fujita, S; Peisach, J | 1 |
| Holm, S | 1 |
| Guengerich, FP | 3 |
| Wishart, GJ | 1 |
| Hook, JB; Kluwe, WM; McCormack, KM | 2 |
| Ishidate, K; Nakazawa, Y; Yoshida, M | 1 |
| Boobis, AR; Nebert, DW; Pelkonen, O | 1 |
| Hepner, GW; Piken, EP | 1 |
| Baird, MB; Birnbaum, LS | 1 |
| Korzeniowski, D; Levin, W; Ryan, DE; Thomas, PE | 1 |
| Hackney, C; Hutton, JJ; Meier, J | 2 |
| Elmamlouk, TH; Mukhtar, H | 1 |
| Korzeniowski, D; Levin, W; Ryan, D; Thomas, PE | 1 |
| Cameron, RG; Farber, E; Joly, JG; Murray, RK; Sharma, RN | 1 |
| Botelho, LH; Levin, W; Ryan, DE | 1 |
| Barone, C; Bartoloni, C; Gambassi, G; Gentiloni, N; Terranova, T | 1 |
| Miki, M; Ozawa, N; Yoshihara, S; Yoshimura, H | 1 |
| Bock, KW; Josting, D; Lilienblum, W; Pfeil, H | 1 |
| Crawford, A; Safe, S | 1 |
| Kamataki, T; Kato, R; Sugiura, M; Yamazoe, Y | 1 |
| Arrhenius, E; Beije, B; Jenssen, D; Zetterqvist, MA | 1 |
| House, ES; Illing, HP | 1 |
| Breuer, H; Hamel-Jönsson, D; Rao, GS | 1 |
| Alexandror, K; Azerad, R; Dansette, PM; Frayssinet, C | 1 |
| Borchert, HH; Pfeifer, S; Schuster, S | 1 |
| Cameron, RG; Farber, E; Griffin, MJ; Joly, JG; Murray, RK; Sharma, RN | 1 |
| Hirose, M; Ito, N; Miyata, Y; Murasaki, G; Nakanishi, K; Tatematsu, M | 1 |
| Biles, C; Michalopoulos, G; Russell, F | 1 |
| Fujii-Kuriyama, Y; Masuda-Mikawa, R; Negishi, M; Tashiro, Y | 1 |
| Kawano, K; Okada, Y; Ozawa, N; Yoshihara, S; Yoshimura, H | 1 |
| Imai, Y | 1 |
| Raw, I; Rockwell, P | 1 |
| Breimer, DD; Danhof, M; Krom, DP | 1 |
| Heubel, F; Netter, KJ | 1 |
| Harada, R; Inokawa, Y; Ishidate, M; Nohmi, T; Yoshikawa, K | 1 |
| Castro, JA; Diaz Gomez, MI | 1 |
| Flemming, K; Gertz, J; Hinkelbein, W; Mull, R | 1 |
| Paumgartner, G; Reichen, J | 1 |
| Arcos, JC; Argus, MF; Brown, CE; Davies, DL | 1 |
| Hietanen, E; Pelkonen, K | 1 |
| Mackinnon, M; Simon, F | 1 |
| Krauss, P; Nehls, P; Remmer, H; Synder, R; Witmer, C | 1 |
| Gaylor, JL; Morris, HP; Williams, MT | 1 |
| Brodie, BB; Byus, CV; Costa, M; Russell, DH; Sipes, IG | 1 |
| Mardones, J; Sánchez, E; Tampier, L | 1 |
| Dent, JG; Gibson, JE; Netter, KJ | 2 |
| Gessner, T | 1 |
| Buynitzky, SJ; Ragland, WL; Tritz, GJ | 1 |
| Cagen, SZ; Gibson, JE; Preache, MM | 1 |
| Ebel, RE; O'keeffe, DH; Peterson, JA | 1 |
| McGuire, PM; Tsibris, JC | 1 |
| Dent, JG; Gibson, JE; Netter, KJ; Roes, U | 1 |
| Flemming, K; Mönig, H; Mull, RH; Schgaguler, M; Voigt, T | 1 |
| Costa, M; Manen, CA; Russell, DH; Sipes, IG | 1 |
| Kon, H; Kumaki, K; Nebert, DW; Sato, M | 1 |
| Kumaki, K; Nebert, DW | 1 |
| Nambara, T; Numazawa, M; Shirao, R; Soeda, N | 1 |
| Cha, YN | 1 |
| Aust, SD; Besaw, LC; Dannan, GA; Moore, RW | 1 |
| Aust, SD; Moore, RW; Sleight, SD | 1 |
| Goldstein, JA | 1 |
| Cresteil, T; Flinois, JP; Leroux, JP; Pfister, A | 1 |
| Appel, KE; Kunz, W; Mahr, B; Rickart, R; Ruf, HH; Schwarz, M | 1 |
| Estabrook, RW; Kawano, S; Werringloer, J | 1 |
| Benko, B; Butschak, G; Jänig, GR; Maricić, S; Rein, H; Ruckpaul, K; Scheunig, G | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Bridges, JW; Burke, MD | 2 |
| Caygill, CP; Diplock, AT; Giasuddin, AS; Jeffery, EH | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Ariji, F; Konno, K; Takusagawa, K; Watanabe, M | 1 |
| Cho, AK; Hodshon, BJ; Jonsson, J; Lindeke, B | 1 |
| Appel, KE; Kunz, HW; Rickart, R; Schwarz, M | 1 |
| Drevon, C; Kuroki, T; Montesano, R | 1 |
| Hétu, C | 1 |
| Joly, JG; Mavier, P; Villeneuve, JP | 2 |
| Bentley, P; Glatt, H; Oesch, F | 1 |
| Glatt, HR; Oesch, F; Raphael, D; Schwind, H | 1 |
| Dahms, RP; Gurtoo, HL; Paigen, B | 1 |
| Belitskiĭ, GA; Bukhman, VM; Konopleva, IA | 1 |
| DePierre, JW; Ernster, L; Johannesen, KA; Moron, MS; Seidegård, J | 1 |
| Guenthner, TM; Mannering, GJ | 2 |
| Gram, TE; Litterst, CL; Mimnaugh, EG | 1 |
| Azhary, RE; Jeffery, E; Kotake, A | 1 |
| Levin, W; Ryan, DE; Thomas, PE | 1 |
| Bock, KW; Josting, D; Ottenwälder, H; von Clausbruch, UC | 1 |
| Berry, DL; Digiovanni, J; Juchau, MR; Slaga, TJ; Thompson, S; Viaje, A | 1 |
| Alvares, AP; Kappas, A | 3 |
| Imai, Y; Iyanagi, T; Sato, R | 1 |
| Hayashi, K; Shimizu, H; Takemura, N | 1 |
| Jones, KG; Krestynski, F; Sweeney, GD | 1 |
| Lu, AY; Miwa, GT; West, SB | 1 |
| Arcos, JC; Argus, MF; Woo, YT | 2 |
| Koivula, T; Koivusalo, M; Marselos, M; Törrönen, R | 1 |
| Jakobsson, SW; Masters, BS; Okita, RT; Patrizi, VW; Prough, RA | 1 |
| Bend, JR; Elmamlouk, TH; Mukhtar, H; Philpot, RM | 1 |
| Eaton, DL; Klaassen, CD | 1 |
| Barnhart, JL; Burk, RF | 1 |
| Francis, KT; Hamrick, ME | 1 |
| Kahl, GF; Klaus, E; Legraverend, C; Nebert, DW; Pelkonen, O | 1 |
| Gaito, JM; Miner, PB | 1 |
| Bridges, JW; Dickins, M; Fennell, TR | 1 |
| Keyler, DE; Mannering, GJ; Renton, KW | 1 |
| Hashimoto, C; Hatano, M; Imai, Y; Nozawa, T; Satake, H; Sato, R; Shimizu, T | 1 |
| Koteen, GM; Legraverend, C; Owens, IS | 1 |
| de Meester, C; Duverger-van Bogaert, M; Lambotte-Vandepaer, M; Mercier, M; Noël, G; Poncelet, F; Roberfroid, M | 1 |
| Sato, R; Shimada, T | 1 |
| Bridges, JW; Fry, JR; Kao, J; Shirkey, RJ | 1 |
| Gromova, OA; Lyakhovich, VV; Polyakova, NE; Rivkind, NB; Tsyrlov, IB | 1 |
| Damani, LA; Gorrod, JW | 1 |
| Aitio, A; Aitio, ML | 1 |
| Burchell, B; Hasani, S | 1 |
| Mansour, B; Pfleger, K; Ullrich, V | 1 |
| Bridges, JW; Chakraborty, J; Shirkey, RS | 1 |
| Guengerich, FP; Mason, PS; Mitchell, MB; Wang, P | 1 |
| Lau, SS; Zannoni, VG | 1 |
| Bornstein, WA; Bresnick, E; Levin, W; Ryan, DE; Thomas, PE | 1 |
| Bridges, JW; Cox, PJ; Farmer, PB; Foster, AB; Jarman, M; McKillop, D | 1 |
| Nesnow, S | 2 |
| Kiyono, Y; Nambara, T; Numazawa, M; Soeda, N | 1 |
| Ellis, S; Gill, DP; Kempen, RR; Nash, JB | 1 |
| Billwitz, H; Böhm, S; Butschak, G; Rein, H; Ruckpaul, K; Scheunig, G | 1 |
| Lowitt, S; Szentivanyi, A; Williams, JF | 1 |
| Addala, SA; Hassall, KA | 1 |
| Burke, MD; Tweedie, DJ | 2 |
| Jergil, B; Schelin, C; Tunek, A | 2 |
| Nakanishi, S; Nishiguchi, K; Saladin, R; Shiohara, E; Tsukada, M; Yamazaki, H | 1 |
| Burdock, GA; Hackett, RB; Masten, LW | 1 |
| Matsuura, T; Nomi, S; Ueda, K; Ueyama, H | 1 |
| Campbell, RL; Hettrick, JM; Nigro, ND; Suppnick, JD | 1 |
| Akhtar, MN; Boyd, DR; Braunstein, A; Hamilton, JG; Jarina, DM; Seifried, HE | 1 |
| Kärki, NT; Nevasaari, K; Pelkonen, O; Vähäkangas, K | 1 |
| Bell, DY; Hodgson, E | 1 |
| Fukuhara, M; Takabatake, E | 1 |
| Mackinnon, AM; Simon, FR; Sutherland, E | 1 |
| Carlson, GP | 3 |
| Bridges, JW; Dickins, M; Elcombe, CR; Netter, KJ | 1 |
| Pearson, DJ; Shas, S | 1 |
| Dahms, R; Gurtoo, HL; Hipkens, J; Vaught, JB | 1 |
| Beckett, AH; Haya, K | 1 |
| Banerjee, S; Van Duuren, BL | 1 |
| Anders, MW; Lindstrom, TD | 1 |
| Gelboin, HV; McCourt, DW; Pezzuto, JM; Yang, CS; Yang, SK | 1 |
| Fahl, WE; Jefcoate, CR; Kasper, CB | 1 |
| Al-Gailany, KA; Bridges, JW; Houston, JB | 1 |
| Greenlee, WF; Poland, A | 1 |
| Gram, TE; Guarino, AM; Litterst, CL; Mimnaugh, EG; Sikic, BI | 1 |
| Burk, RF; Correia, MA | 1 |
| Sanders-Bush, E; Steranka, LR | 1 |
| Abernathy, CO; Ezekiel, M; Utili, R; Zimmerman, HJ | 1 |
| Huang, MT; Lu, AY; Miwa, GT | 1 |
| Emory, TH; Gutmann, HR; Kaplan, E | 1 |
| Clifton, G; Kaplowitz, N | 2 |
| Jerina, DM; O'Brien, PJ; Rahimtula, AD; Seifried, HE | 1 |
| Coon, MJ; Fasco, MJ; Kaminsky, LS; Vatsis, KP | 1 |
| Beatty, PW; Neal, RA; Vaughn, WK | 1 |
| Hammer, CT; Wills, ED | 1 |
| Chaturapit, S; Holder, GM | 1 |
| Bridges, JW; Fry, JR; Jones, CA; Lowing, RK; Wiebkin, P | 1 |
| Gielen, JE; Kremers, P; Pasleau, F | 2 |
| Aichinger, G; Hlavica, P | 1 |
| Lutz, WK; Viviani, A | 1 |
| Lutz, WK; Schlatter, C; Viviani, A | 1 |
| Baars, AJ; Breimer, DD; Jansen, M | 1 |
| Hashimoto-Yutsudo, C; Imai, Y; Kitagawa, T; Kyogoku, Y; Ozaki, Y; Sato, R | 1 |
| Safe, S; Wyndham, C | 1 |
| Vainio, H; Zitting, A | 1 |
| Baron, J; Guengerich, FP; Redick, JA | 3 |
| Gentile, JM; Overton, LK; Schubert, J | 1 |
| Bardin, CW; Brown, TR; Bullock, LP; Greene, FE | 1 |
| de Matteis, F; Unseld, A | 1 |
| Parke, DV; Poole, TW | 1 |
| Fawade, MM; Pawar, SS | 1 |
| Depierre, JW; Mannervik, B; Moron, MS | 1 |
| Chauveau, J; Decloitre, F; Martin, M | 2 |
| Gangolli, SD; Hodgson, RA; Lake, BG; Lloyd, AG; Longland, RC; Severn, BJ | 1 |
| Daly, JW; Jerina, DM; Selander, HG | 2 |
| Aust, SD; Chaney, LC; O'Neal, FO; Welton, AF | 1 |
| Flemming, K; Mull, RH; Voigt, T | 1 |
| Banerjee, S; Conney, AH; Kuntzman, R; Levin, W; Somogyi, A | 1 |
| Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; West, Sk | 1 |
| Bock, KW; Remmer, H; Rexer, B | 1 |
| Parke, DV | 1 |
| Clifton, G; Kaplowitz, N; Kuhlekamp, J | 1 |
| Capdevila, J; Helia, O; Jakobsson, SW; Jernström, B; Orrenius, S | 1 |
| Felton, JS; Nebert, DW | 3 |
| Hietanen, E; Laitinen, M; Lang, M; Vainio, H | 2 |
| Aust, SD; Welton, AF | 3 |
| Kinoshita, H; Yamamoto, H; Yoshimura, H | 1 |
| Cavalieri, E; Mailander, P; Rogan, EG | 1 |
| Gromova, OA; Lyakhovich, VV; Tsyrlov, IB; Zakharova, NE | 1 |
| Conney, AH; Kuntzman, R; Lu, AY | 1 |
| Balanski, RM; Dzhioev, FK | 1 |
| Bridges, JW; McPherson, FJ; Parke, DV | 1 |
| Czygan, P; Fröhling, W; Kommerell, B; Stiehl, A | 1 |
| Aitio, A; Vainio, H | 2 |
| Baird, MB; Birnbaum, LS; Massie, HR | 1 |
| Burke, MD; Grafström, RC; Moldéus, PW; Orrenius, SG; Stohs, SJ | 1 |
| Birke, FW; Bock, KW; Lorch, F; van Ackeren, G | 1 |
| Baird, MB; Birnbaum, LS; Massie, HR; Samis, HB; Zimmerman, JA | 1 |
| Jensen, NM; Kumaki, K; Nebert, DW; Shire, JG | 1 |
| Yang, CS | 1 |
| Pohl, LR; Porter, WR; Trager, WF | 1 |
| Beaubien, AR; Thomas, BH; Zeitz, W | 1 |
| Turner, DM | 1 |
| Hales, BJ; Neims, AH | 1 |
| Dansette, PM; Jerina, DM | 1 |
| Kimura, T; Kodama, M; Nagata, C | 1 |
| Alexandrov, K; Thompson, MH | 1 |
| Conney, AH; Cooper, DY; Kuntzman, R; Levin, W; Lu, AY; Rosenthal, O; Schleyer, H | 1 |
| Duceman, BW; Leonard, TB; Smith, SJ; Vesell, ES | 1 |
| Bresnick, E; Dansette, PM; Jerina, DM; Mukhtar, H; Stoming, TA | 1 |
| Breuer, H; Haueter, G; Rao, GS; Rao, ML | 1 |
| Atlas, SA; Boobis, AR; Felton, JS; Nebert, DW; Thorgeirsson, SS | 1 |
| McDevitt, DG; Nies, AS; Wilkinson, GR | 1 |
| Fahl, WE; Jefcoate, CR; Nesnow, S | 2 |
| Bell, P; Gutmann, HR | 1 |
| Gromova, OA; Liakhovich, VV; Tsyrlov, IB; Zakharova, NE | 1 |
| Levin, W; Lu, AY; Miwa, GT; Ryan, D; Thomas, PE; West, SB | 1 |
| Cho, AK; Sum, CY | 1 |
| Berzins, K; Blomberg, F; Raftell, M | 1 |
| Gromova, OA; Liakhovich, VV; Rivkind, NB; Tsyrlov, IB; Vakulin, GM | 1 |
| Kessler, C; Mohn, G; Niederlaender, P | 1 |
| Takagi, M | 2 |
| Gurtoo, HL; Klohs, W; Vaught, JB | 1 |
| Aldridge, A; Neims, AH; Parsons, WD | 1 |
| Bergman, A; Dallner, G | 1 |
| David, JC | 1 |
| Elliot, S; Gelboin, HV; Waters, HL; Wiebel, FJ | 1 |
| Bresnick, E; Mukhtar, H | 2 |
| Michalopoulos, G; Pitot, HC; Sattler, CA; Sattler, GL | 1 |
| Nelson, WL; Thorgeirsson, SS | 1 |
| Chhabra, RS; Fouts, JR; Philpot, RM; Tredger, JM | 1 |
| Koike, M; Matsubara, T; Sugeno, K; Tochino, Y; Touchi, A | 1 |
| McDevitt, DG; Nies, AS; Rush, BD; Strother, JR; Wilkinson, GR | 1 |
| Konstantinov, IuM; Liakhovich, VV; Panov, AV; Solov'ev, VN; Vavilin, VA | 1 |
| Klaassen, CD | 7 |
| Friedman, MA | 1 |
| Estabrook, RW; Patrizi, VW; Prough, RA | 1 |
| Huang, MT; Kawalek, J; Levin, W; Lu, AY; Ryan, D; Thomas, P; West, SB | 1 |
| Gillette, JR; Mitchell, JR; Snodgrass, WR | 1 |
| Conney, AH; Levin, W; Lu, AY; Thakker, DR; Yagi, H | 1 |
| Hamada, K; Teranishi, K; Watanabe, H | 1 |
| McDonagh, AF; Schmid, R | 1 |
| Frantz, CN; Malling, HV | 1 |
| Hackney, C; Hutton, JJ | 1 |
| O'Brien, PJ; Rahimtula, AD | 2 |
| Argyris, TS; Augenlicht, LH | 1 |
| Levin, W; Lu, AY; Ryan, D; West, S | 2 |
| Pelkonen, O; Vainio, H | 1 |
| Daly, JW; Jerina, DM; Tomaszewski, JE | 1 |
| Carlson, GP; Shah, HC | 1 |
| May, HE; Reed, DJ | 1 |
| Gelboin, HV; Leutz, JC | 1 |
| Kawalek, J; Levin, L; Lu, YH; Ryan, D; West, SB | 1 |
| Alexandrov, K; Frayssinet, C | 2 |
| Oesch, F | 3 |
| Holtzman, JL; Montgomery, MR | 1 |
| Konno, K; Sato, H; Watanabe, M | 1 |
| Hes, J; Sternson, LA | 1 |
| Belpaire, FM; Bogaert, MG | 1 |
| Czygan, P; Garro, AJ; Greim, H; Hutterer, F; Popper, H; Schaffner, F | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Heidelberger, C; Nesnow, S | 1 |
| Drew, RT; Gupta, BN; Harper, C; Talley, FA | 1 |
| Clifton, G; Kaplowitz, N; Kuhlenkamp, J; Wallin, JD | 1 |
| Boose, R; May, HE; Reed, DJ | 1 |
| Drew, RT; Fouts, JR; Lo, RJ; Roth, RP | 1 |
| Gelboin, HV; Wiebel, FJ | 1 |
| Darracq, N; Lesage, V; Moulé, Y; Rousseau, N | 1 |
| Holscher, M; Mgbodile, MU; Neal, RA | 1 |
| Flemming, K; Mull, RH; Schgaguler, M | 1 |
| Bresnick, E; Procaccini, RL | 1 |
| Akhrem, AA; Dvornikov, SS; Metelitsa, DI; Usanov, SA | 1 |
| Gangolli, SD; Heading, CE; Lake, BG; Lloyd, AG; Phillips, JC | 1 |
| Brodeur, J; Lambert, G | 1 |
| Carlson, GP; Fuller, GC; Suarez, KA | 1 |
| Atlas, AS; Boobis, AR; Kumaki, K; Nebert, DW; Thorgeirsson, SS | 1 |
| Mungikar, AM; Pawar, SS | 1 |
| Galdhar, NR; Mungikar, AM; Pawar, SS | 1 |
| Liakovich, VV; Mishin, VM; Pokrovskiĭ, AG; Pospelova, LN | 1 |
| Kumaoka, H; Yoshida, Y | 1 |
| Lohmann, SM; Miech, RP | 1 |
| Arcos, JC; Argus, MF; Bryant, GM; Buu-Hoi, NP; Valle, RT | 1 |
| Docks, EL; Krishna, G | 1 |
| Gangolli, SD; Lake, BG; Lloyd, AG; Longland, RC | 1 |
| Hashimoto, C; Imai, Y | 1 |
| Arcos, JC; Argus, MF; Pastor, KM; Venkatesan, N; Wu, BC | 1 |
| Gillette, JR | 4 |
| Drummond, AH; Jondorf, WR; Macintyre, DE; Powis, G | 1 |
| Guinaudy, MJ; Kremers, P; Lesca, P; Marty, J; Rivière, JL | 1 |
| Prasad, TN; Stiff, DD; Venkataramanan, R | 1 |
| Couture, J; Dahlström-King, L; Plaa, GL | 1 |
| Renczes, G; Szabó, I; Vas, A | 1 |
| Lin, DX | 1 |
| Cederbaum, AI; Puntarulo, S | 1 |
| Kikkawa, Y; Park, SS; Sakai, H | 1 |
| Lesca, P; Peryt, B; Szymczyk, T | 1 |
| Kato, S; Yamamoto, K | 3 |
| Horbach, GJ; Kremers, P; Rietjens, IM; Van Asten, JG; Van Bezooijen, CF | 1 |
| Albores, A; Bach, PH; Bridges, JW; Cebrian, ME; Connelly, JC | 1 |
| Basile, AS; de Costa, B; Paul, IA | 1 |
| Baird, S; Bock, KW; Burchell, B; Gschaidmeier, H; Seidel, A | 1 |
| Berthou, F; Cauvin, JM; Deitrich, RA; Lucas, D; Ménez, JF | 1 |
| Hatolkar, VS; Pawar, SS | 1 |
| Horie, T; Tanaka, S; Yoshimura, T | 1 |
| Florence, R; McDonnell, WM; Traber, PG; Wang, W | 1 |
| Hsieh, CY; Huang, JD | 1 |
| Balvers, WG; Boersma, MG; Rietjens, IM; Veeger, C | 1 |
| Barter, RA; Klaassen, CD | 2 |
| Iyanagi, T; Uchiyama, Y; Waguri, S | 1 |
| Catinot, R; Cordier, A; de Sandro, V; Kriszt, W; Richert, L | 1 |
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| GELBOIN, HV; SOKOLOFF, L | 1 |
| CONNEY, AH; KLUTCH, A | 1 |
| KUROIWA, Y; MINEGISHI, KI; OKUI, S | 1 |
| CONNEY, AH; GILMAN, AG | 1 |
| DUBOIS, KP; KINOSHITA, F | 1 |
| BRESNICK, E; YANG, HY | 1 |
| BURNS, JJ; CONNEY, AH | 1 |
| POTTER, VR | 1 |
| CONNEY, AH; SCHNEIDMAN, K | 1 |
| CONNEY, AH; JACOBSON, M; KUNTZMAN, R; SCHNEIDMAN, K | 2 |
| FOUTS, JR; ROGERS, LA | 1 |
| BURNS, JJ; CONNEY, AH; CUCINELL, SA; KOSTER, R | 1 |
| Ito, K; Kanbori, M; Kiyosawa, N; Manabe, S; Niino, N; Sakuma, K; Watanabe, T; Yamoto, T | 1 |
| Atsriku, C; Grant, MH; Skellern, GG; Watson, DG | 1 |
| Aliya, S; Devi, KN; Hemavathi, B; Raveendra, A; Thyagaraju, K | 1 |
| Ahr, HJ; Duan, JD; Enzmann, HH; Jeffrey, AM; Perrone, CE; Schmidt, U; Williams, GM | 1 |
| Bauer, AW; Brulport, M; Feilen, PJ; Hengstler, JG; Hermes, M; Oesch, F; Ringel, M; Santos, R; Schön, MR; Schormann, W; Tanner, B; von Mach, MA | 1 |
| Bae, SK; Kim, T; Kim, YH; Lee, MG; Lee, SJ | 1 |
| Haraguchi, K; Kato, Y; Koga, N; Ohta, C | 1 |
| Devi, KN; Hemavathi, B; Rao, AD; Thyagaraju, K; Vasundhara, K | 1 |
| Kirby, GM; Ng, L; Romero, L | 1 |
| Huang, M; Le, J; Peng, RX; Wang, H | 1 |
| Kon, J; Mitaka, T; Miyamoto, S; Ninomiya, S; Ooe, H; Ozone, Y | 1 |
| Archakov, A; Lisitsa, A; Serebriakova, M; Tikhonova, O; Viglinskaya, A; Zgoda, V | 1 |
| Boibessot, I; Grant, MH; Skellern, GG; Tettey, JN; Watson, DG | 1 |
| Endo, T; Haraguchi, K; Kato, Y; Koga, N; Matsuoka, M; Ohta, C | 1 |
| Haraguchi, K; Ishii, T; Kato, Y; Koga, N; Matsuo, M; Matsuoka, M; Ohta, C; Ohta, H; Yano, M | 1 |
| Dhawan, A; Johri, A; Parmar, D; Yadav, S | 1 |
| Castell, JV; Donato, MT; Gómez-Lechón, MJ; Lahoz, A; Picazo, L | 1 |
| Chatuphonprasert, W; Jarukamjorn, K; Kawasaki, Y; Kondo, S; Nemoto, N; Sakuma, T | 1 |
| McCoy, GD | 1 |
| Jain, SK; Parmar, D; Saurabh, K; Sharma, A; Yadav, S | 1 |
| Evans, PJ | 1 |
| Goto, H; Ito, Y; Matsumoto, S; Sato, M; Senba, T; Takeuchi, K; Umehara, K; Yamada, H | 1 |
23 review(s) available for 3-methylcholanthrene and phenobarbital
| Article | Year |
|---|---|
Interaction of chemical carcinogens and drug-metabolizing enzymes in primary cultures of hepatic cells from the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cells, Cultured; Collagen; Cytochrome P-450 Enzyme System; DNA Repair; Drug Interactions; Enzyme Induction; Enzymes; Female; Hydrocortisone; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnancy; Rats; Tyrosine Transaminase | 1976 |
[Metabolic activation of hepatotoxins and carcinogens: induction by alcohol and drugs].
Topics: Aniline Compounds; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ethanol; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding | 1977 |
Characterization of rat lung epoxide (styrene oxide) hydrase with a modified radioactive assay of improved sensitivity.
Topics: Alcohols; Animals; Benzopyrene Hydroxylase; Cyclohexanes; Cyclohexenes; Endoplasmic Reticulum; Enzyme Induction; Epoxide Hydrolases; Ethers, Cyclic; Hydro-Lyases; Hydrocarbons, Chlorinated; In Vitro Techniques; Kinetics; Liver; Lung; Male; Methods; Methylcholanthrene; Microsomes; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Polycyclic Compounds; Rats; Styrenes | 1977 |
Induction of the drug-metabolizing enzymes.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Barbiturates; Benzopyrene Hydroxylase; Benzopyrenes; Cytochrome P-450 Enzyme System; Diet; Endoplasmic Reticulum; Enzyme Induction; Female; Glucuronosyltransferase; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pregnancy; Proadifen; Protein Biosynthesis; Rats; Species Specificity; Transcription, Genetic | 1975 |
The liver microsomal hydroxylation enzyme system. Induction and properties of the functional components.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxygenases; Pharmacology; Phenobarbital; Spectrophotometry; Steroid Hydroxylases | 1976 |
The enzymatic formation of bilirubin.
Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen | 1975 |
[Expression of cytochrome P-450 genes].
Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Liver; Methylcholanthrene; Mice; Oxidation-Reduction; Phenobarbital; Pituitary Hormones, Anterior; Pregnenolone Carbonitrile; Transcription, Genetic | 1992 |
Comparative aspects on the bioaccumulation, metabolism and toxicity with PCBs.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Ecology; Environmental Pollutants; Enzyme Induction; Humans; Methylcholanthrene; Microsomes; Oxygenases; Phenobarbital; Polychlorinated Biphenyls | 1991 |
The 4S binding protein acts as a trans-regulator of the polycyclic hydrocarbon-inducible cytochrome P450.
Topics: Animals; Benzo(a)pyrene; Carrier Proteins; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Methylcholanthrene; Phenobarbital; Rats | 1988 |
Induction of drug-metabolizing enzymes: mechanisms and consequences.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Environmental Pollutants; Enzyme Induction; Humans; Inactivation, Metabolic; Methylcholanthrene; Neoplasms; Pharmaceutical Preparations; Phenobarbital | 1986 |
[Recent progress in studies of the drug-metabolizing enzyme cytochrome P-450].
Topics: Animals; Cytochrome P-450 Enzyme System; Genes; Methylcholanthrene; Molecular Weight; Phenobarbital; Plasmids; Promoter Regions, Genetic; Sequence Homology, Nucleic Acid | 1986 |
Induction of microsomal cytochrome P-450 enzymes: the first Bernard B. Brodie lecture at Pennsylvania State University.
Topics: Amino Acid Sequence; Amino Acids; Animals; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Dietary Proteins; Drug Interactions; Enzyme Induction; Ethionine; Female; Humans; Inactivation, Metabolic; Isoenzymes; Methionine; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Pregnancy; Smoking | 1986 |
Effects of steroids upon the liver ultrastructure.
Topics: Animals; Benzopyrenes; Desoxycorticosterone; Endocrine Glands; Enzyme Induction; Glucocorticoids; Glycogen; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Norpregnenes; Phenobarbital; Pregnenolone Carbonitrile; Protein Biosynthesis; RNA; Spironolactone; Steroids | 1973 |
Hepatic microsomal enzyme induction.
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Drug Interactions; Electron Transport; Endoplasmic Reticulum; Environmental Exposure; Enzyme Induction; Hormones; Humans; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital | 1973 |
Sex-related differences in drug metabolism.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Estradiol; Female; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Pentobarbital; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Proadifen; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet; Strychnine; Testosterone | 1974 |
[Ultramicroscopic pathology of the liver].
Topics: Adenosine Triphosphatases; Aminopyrine; Animals; Bile; Cytoplasm; Glucose; Humans; Hypoxia; Lipoproteins; Liver; Liver Diseases; Methylcholanthrene; Microscopy, Electron; Oxidative Phosphorylation; Phenobarbital; Proteins; Rats; Water | 1968 |
Oxygenated cytochrome P-450 as an intermediate in hydroxylation reactions.
Topics: Aniline Compounds; Blood Proteins; Camphor; Chemistry, Organic; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Electron Transport; Hexobarbital; Hydrogen-Ion Concentration; Hydroxylation; Iron; Methylcholanthrene; Microsomes, Liver; Models, Chemical; Models, Structural; Organic Chemistry Phenomena; Oxidation-Reduction; Phenobarbital; Pseudomonas; Spectrophotometry; Spectrum Analysis | 1972 |
Studies on the mechanism of microsomal hydroxylase induction and its role in carcinogen action.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Carbon Isotopes; Carcinogens; Cells, Cultured; Cricetinae; Cytidine; Dactinomycin; Electrophoresis; Enzyme Induction; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Neoplasms; Phenobarbital; Protein Biosynthesis; Rats; RNA; RNA Nucleotidyltransferases; Tritium; Uridine | 1972 |
[Enzyme induction in the liver--its mechanism and clinical significance].
Topics: Animals; Cushing Syndrome; DNA; Dogs; Drug Synergism; Enzyme Induction; Enzyme Repression; Glucocorticoids; Humans; Hyperbilirubinemia; Insecticides; Liver; Methylcholanthrene; Phenobarbital; Protein Biosynthesis; Rats; RNA, Messenger; Testosterone | 1972 |
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
Topics: Animals; Antimetabolites; Benz(a)Anthracenes; Binding Sites; Carcinogens; Enzyme Induction; Ethers, Cyclic; Guinea Pigs; Humans; Hydro-Lyases; Kinetics; Male; Membranes; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Prostate; Prostatic Neoplasms; Species Specificity; Structure-Activity Relationship | 1973 |
Microsomes, metabolism and toxicity.
Topics: Animals; Barbiturates; Biotransformation; Carbon Tetrachloride; DDT; Enzyme Induction; Female; Hexobarbital; Male; Methylcholanthrene; Mice; Microsomes, Liver; Pesticides; Phenobarbital; Pituitary Hormones, Anterior; Protein Deficiency; Rabbits; Rats; Steroids; Toxicology | 1969 |
Induction of the drug-metabolizing enzymes.
Topics: Aldehyde Oxidoreductases; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Glucuronosyltransferase; Glutathione Transferase; Humans; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Quinone Reductases; Rats | 1982 |
Hepatic drug metabolism and anesthesia.
Topics: Acute Kidney Injury; Anesthetics; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorides; Halothane; Humans; Liver; Methoxyflurane; Methylcholanthrene; Phenobarbital | 1980 |
1472 other study(ies) available for 3-methylcholanthrene and phenobarbital
| Article | Year |
|---|---|
SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro.
Topics: Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cyclophilin A; Cyclosporins; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Haplorhini; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Immunosuppressive Agents; Interleukin-2; Jurkat Cells; Leukocytes, Mononuclear; Mice; Molecular Structure; Rats; RNA, Viral; Virus Replication | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Radiochemical assay of glutathione S-epoxide transferase and its enhancement by phenobarbital in rat liver in vivo.
Topics: Animals; Carrier Proteins; Epoxy Compounds; Glutathione; Glutathione Transferase; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Stimulation, Chemical; Styrenes | 1975 |
The effects of the continuous administration of N,N-dimethyl-4-phenylazoaniline (DAB) on the activities and the inducibilities of some drug-metabolizing enzymes in rat liver.
Topics: Animals; Carbon Monoxide; Cerebroside-Sulfatase; Cytochrome P-450 Enzyme System; Glucuronidase; Liver; Lysosomes; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitrate Reductases; Oxidoreductases; Oxidoreductases, N-Demethylating; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1975 |
Some characteristics of two azoreductase systems in rat liver. Relevance to the activity of 2-[4'-di(2"-bromopropyl)-aminophenylazo]benzoic acid (CB10-252), a compound possessing latent cytotoxic activity.
Topics: Animals; Azo Compounds; Cecum; Cell Fractionation; Cytosol; Enzyme Induction; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Organ Specificity; Oxidoreductases; Phenobarbital; Rats; Subcellular Fractions | 1975 |
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes.
Topics: Animals; Azides; Ethanol; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone; Rats; Scopoletin | 1975 |
A re-evaluation of the optical titrations of the 430 and 455 nm chromophore of ethyl isocyanide complexes of mamalian hepatic cytochrome P-450.
Topics: Animals; Chromatophores; Computers; Cyanides; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1975 |
An investigation into the hepatic cytochrome P-450 catalysed metabolism of the anaesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether).
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ether; Ethers; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1975 |
Fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome P-450 in vitro.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Ethyl Ethers; Heme; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Time Factors | 1975 |
Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Thiones; Time Factors | 1975 |
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1975 |
NADH-dependent O-deethylation of p-nitrophenetole with rabbit liver microsomes.
Topics: Animals; Carbon Monoxide; Cobalt; Copper; Cytochrome P-450 Enzyme System; Cytochromes; Ethyl Ethers; Hydrogen-Ion Concentration; Iron; Kinetics; Male; Mercury; Methylcholanthrene; Microsomes, Liver; NAD; Oxidoreductases; Oxygen Consumption; Partial Pressure; Phenobarbital; Rabbits | 1976 |
Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450.
Topics: Amines; Aniline Compounds; Animals; Binding, Competitive; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Imipramine; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxides; Oxygen Consumption; Phenobarbital; Rats; Subcellular Fractions | 1976 |
The role of cytochrome P-450 in the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether) anaesthesia in vivo.
Topics: Allylisopropylacetamide; Anesthesia; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1976 |
Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes.
Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Genes, Dominant; Hydrogen-Ion Concentration; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mutation; Oxygenases; Phenobarbital; Protein Binding; Protein Conformation; Spectrophotometry | 1976 |
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes | 1976 |
A highly sensitive radiometric assay for zoxazolamine hydroxylation by liver microsomal cytochrome P-450 and P-448: properties of the membrane-bound and purified reconstituted system.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydrogen-Ion Concentration; Kinetics; Membranes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Tritium; Zoxazolamine | 1976 |
Rat liver cells in culture: effect of storage, long-term culture, and transformation on some enzyme levels.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Culture Media; Enzyme Induction; Freezing; Liver; Methylcholanthrene; Neoplasms, Experimental; Phenobarbital; Preservation, Biological; Rats; Tyrosine Transaminase | 1976 |
In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates.
Topics: Amphetamines; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Niacinamide; Phenobarbital; Rats | 1976 |
Michaelis--Menten kinetic analysis of the hepatic microsomal benzpyrene hydroxylase from control, phenobarbital- and methyl-3-cholanthrene-treated rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proteins; Rats; Temperature; Time Factors | 1977 |
The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Vinyl Chloride; Vinyl Compounds | 1977 |
Interaction of nitromethane with reduced hepatic microsomal cytochrome P-450.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Nitro Compounds; Oxidation-Reduction; Phenobarbital; Rabbits; Spectrophotometry | 1977 |
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital | 1977 |
The induction of sister chromatid exchanges by cyclophosphamide in the presence of differently induced microsomal fractions of rat liver.
Topics: Animals; Aroclors; Benzopyrene Hydroxylase; Cells, Cultured; Chromatids; Cyclophosphamide; Enzyme Induction; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats | 1977 |
[Relation between the drug-metabolizing activities of liver microsomes and multiplicity of cytochrome P-450 (author's transl)].
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Hydrocortisone; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Rats | 1978 |
Circular dichroism studies on the binding of type I substrates and reverse type I compounds to rabbit liver microsomal cytochrome P-450.
Topics: Alcohols; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Circular Dichroism; Cyclohexanes; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rabbits | 1978 |
Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Catalysis; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethyl Ethers; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats | 1978 |
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.
Topics: Aflatoxins; Animals; Chemical Phenomena; Chemistry; Cricetinae; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats | 1978 |
Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
Topics: Animals; Biotransformation; Biphenyl Compounds; DNA; Female; Lactation; Male; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Phenobarbital; Polybrominated Biphenyls; Pregnancy; Protein Binding; Rats | 1978 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
Covalent binding of carbaryl (1-naphthyl-N-methyl-carbamate) to rat liver microsomes in vitro.
Topics: Animals; Carbaryl; Electrophoresis, Disc; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pronase; Protein Binding; Rats | 1979 |
[Cytochrome P-450 catalyzed oxidation of 1-piperidinoanthraquinone].
Topics: Animals; Anthraquinones; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme System; Deoxycholic Acid; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Piperidines; Rats; Spectrum Analysis | 1979 |
The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation.
Topics: Animals; Benzopyrene Hydroxylase; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Isoelectric Point; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1979 |
Effects of inducers and inhibitors on the metabolism of aflatoxin B1 by rat and mouse.
Topics: Aflatoxins; Animals; Benzopyrenes; DNA; Enzyme Induction; Enzyme Inhibitors; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Rats; Species Specificity; Time Factors | 1979 |
Factors influencing the microsome- and mitochondria-catalyzed in vitro binding of diethylnitrosamine and N-nitrosopiperidine to deoxyribonucleic acid.
Topics: Animals; Cytosol; Diethylnitrosamine; DNA; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Nitrosamines; Phenobarbital; Piperidines; Rats | 1979 |
Effect of phenobarbital and 3-methylcholanthrene on decrease in pH in liver induced by 3'-methyl-4-dimethylaminoazobenzene, of partial hepatectomy and hepatotoxic agents.
Topics: Animals; Chemical and Drug Induced Liver Injury; Hepatectomy; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Methylcholanthrene; Methyldimethylaminoazobenzene; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1979 |
Differential inhibition of rat liver sialyltransferase(s) by various aflatoxins and their metabolites.
Topics: Aflatoxins; alpha-Fetoproteins; Animals; Cell Membrane; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sialyltransferases; Transferases | 1975 |
[Metabolism and in vitro binding of several organochlorine and organophosphate pesticides to calf thymus DNA and rat liver microsomal proteins].
Topics: Aldrin; Animals; Binding Sites; Biotransformation; Cattle; Dieldrin; DNA; Hexachlorocyclohexane; Insecticides; Male; Methylcholanthrene; Microsomes, Liver; Parathion; Phenobarbital; Proteins; Rats; Stimulation, Chemical | 1975 |
Study of the stereoselectivity of the para-hydroxylation of diphenylhydantoin by the rat liver microsomal cytochrome P-450-dependent enzymes [proceedings].
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Substrate Specificity | 1978 |
In vitro benzo[a]pyrene metabolism from lindane-treated rat liver: effect of oral and acute administration, and comparison with phenobarbital and methylcholanthrene pretreatment.
Topics: Administration, Oral; Animals; Benzopyrene Hydroxylase; Benzopyrenes; DNA; Enzyme Induction; Epoxide Hydrolases; Hexachlorocyclohexane; Hydroxylation; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Time Factors | 1979 |
Purification of cytochrome P-450 by double chromatography on substituted Sepharose. Effect of type I and type II ligands [proceedings].
Topics: Animals; Chromatography, Gel; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Methylcholanthrene; Microsomes; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Sepharose | 1979 |
Liver microsomal cytochromes P-450 and azoreductase activity.
Topics: Amaranth Dye; Animals; Azo Compounds; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1978 |
Metabolism of 2,4,5,2',5'-Pentachlorobiphenyl by lung and liver microsomes.
Topics: Animals; Female; Haplorhini; Humans; In Vitro Techniques; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred CBA; Microsomes; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Saimiri | 1978 |
Separation and purification of multiple forms of microsomal cytochrome P-450. Partial characterization of three apparently homogeneous cytochromes P-450 prepared from livers of phenobarbital- and 3-methylcholanthrene-treated rats.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Immunodiffusion; Isoenzymes; Kinetics; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Precipitin Tests; Rats | 1978 |
Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats.
Topics: Animals; Enzyme Activation; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Substrate Specificity | 1978 |
Selective modification of the renal and the hepatic toxicities of chloroform by induction of drug-metabolizing enzyme systems in kidney and liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chloroform; Enzyme Induction; Inactivation, Metabolic; Kidney; Liver; Male; Methylcholanthrene; Mice; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins | 1978 |
Effect of typical inducers of microsomal drug-metabolizing enzymes on phospholipid metabolism in rat liver.
Topics: Animals; Biotransformation; Choline; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phospholipids; Polychlorinated Biphenyls; Rats | 1978 |
Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice.
Topics: Animals; Benzopyrenes; Cyclohexanes; DNA; Enzyme Induction; Enzyme Inhibitors; Ethanol; Flavonoids; In Vitro Techniques; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Species Specificity | 1979 |
Detection of carcinogen-induced stimulation of cytochrome P-448-associated enzymes by 14CO2 breath analysis studies using dimethylaminoazobenzene.
Topics: Aminopyrine N-Demethylase; Animals; Aroclors; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Cytochromes; Dioxanes; Dioxins; Enzyme Induction; Evaluation Studies as Topic; Liver; Male; Methods; Methylcholanthrene; Oxidoreductases, N-Demethylating; p-Dimethylaminoazobenzene; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Rats | 1979 |
Induction of hepatic mixed function oxidases in senescent rodents.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Benzphetamine; Biotransformation; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ethylmorphine-N-Demethylase; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnanolone; Rats | 1978 |
Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.
Topics: Animals; Aroclors; Carbon Monoxide; Cytochrome P-450 Enzyme System; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Peptide Fragments; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry | 1979 |
Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.
Topics: Animals; Benzopyrenes; Biotransformation; Dimethylnitrosamine; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Mutagens; Nitrosamines; Phenobarbital; Polychlorinated Biphenyls; Tissue Distribution | 1979 |
trans-Stilbene oxide: a new inducer of rat liver microsomal UDP-glucuronyltransferase.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Rats; Stilbenes | 1979 |
Preparation of monospecific antibodies against two forms of rat liver cytochrome P-450 and quantitation of these antigens in microsomes.
Topics: Animals; Antibodies; Antigens; Cytochrome P-450 Enzyme System; Immunodiffusion; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1979 |
Multiple patterns of induction of rat liver microsomal mono-oxygenases and other polypeptides by xenobiotics [proceedings].
Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone; Rats; Safrole | 1979 |
Amino acid compositions and partial amino acid sequences of three highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, or 3-methylcholanthrene.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aroclors; Cytochrome P-450 Enzyme System; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Polychlorinated Biphenyls; Rabbits; Rats; Species Specificity | 1979 |
Effects of phenobarbital and 3-methylcolanthrene treatment on microsomes of Morris hepatoma 3924-A, tumour-bearing and normal rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Cell Membrane; Cytochrome P-450 Enzyme System; Cytochromes; Cytoplasm; Liver; Liver Neoplasms, Experimental; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats | 1979 |
Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats.
Topics: Animals; Body Weight; Cell Fractionation; Cytochrome P-450 Enzyme System; Enzyme Induction; Lipid Metabolism; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Quinone Reductases; Rats; Spleen; Thymus Gland | 1979 |
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats | 1979 |
4-chlorobiphenyl metabolism: the effects of chemical inducers.
Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats | 1979 |
Purification and properties of cytochrome P-450 and NADPH-cytochrome c (P-450) reductase from human liver microsomes.
Topics: Cytochrome P-450 Enzyme System; Cytochrome Reductases; Humans; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital | 1979 |
Isolated liver perfusion--a tool in mutagenicity testing for the evaluation of carcinogens.
Topics: Animals; Aroclors; Cell Line; Cricetinae; Cytochrome P-450 Enzyme System; Gluconeogenesis; Lactates; Liver; Lung; Male; Methylcholanthrene; Microsomes, Liver; Mutation; Perfusion; Phenobarbital; Polychlorinated Biphenyls; Protein Biosynthesis; Rats; Urea | 1979 |
A simple radiometric procedure for measuring phenol UDP-glucuronosyltransferase activity in vitro and some properties of the enzyme [proceedings].
Topics: Animals; Carbon Radioisotopes; Glucuronosyltransferase; Isotope Labeling; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenols; Rats | 1979 |
Induction of steroid glucuronyltransferase and repression of hydroxysteroid oxidoreductase: recent findings.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Castration; Enzyme Induction; Enzyme Repression; Estradiol; Estradiol Dehydrogenases; Estrone; Female; Glucuronosyltransferase; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1979 |
The effect of some mixed function oxidase inducers on aryl hydrocarbon hydroxylase and epoxide hydrase in nuclei and microsomes from rat liver and lung. The effect of cigarette smoke.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Nucleus; Enzyme Induction; Epoxide Hydrolases; Liver; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Smoking | 1979 |
[The influence of carbamazepine and clonazepam on UDP-glucuronyltransferase activity].
Topics: Animals; Benzodiazepinones; Carbamazepine; Clonazepam; Glucuronosyltransferase; In Vitro Techniques; Liver; Methylcholanthrene; Phenobarbital; Rats | 1979 |
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics.
Topics: 2-Acetylaminofluorene; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Biosynthesis; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Safrole | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Precancerous Conditions; Rats; Rats, Inbred F344 | 1979 |
Primary cultures of hepatocytes on human fibroblasts.
Topics: Animals; Cell Adhesion; Cells, Cultured; Collagen; Cytochrome P-450 Enzyme System; Fibroblasts; Humans; Liver; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proteins; Rats | 1979 |
Purification and partial characterization of hepatic microsomal cytochrome P-450s from phenobarbital- and 3-methylcholanthrene-treated rats.
Topics: Amino Acids; Animals; Antibodies; Cytochrome P-450 Enzyme System; Immunoassay; Immunodiffusion; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Spectrophotometry; Substrate Specificity | 1979 |
Mutagenicity and metabolism of dimethylnitrosamine and benzo[alpha]pyrene in tissue homogenates from inbred Syrian hamsters treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.
Topics: Animals; Benzopyrenes; Biotransformation; Cricetinae; Dimethylnitrosamine; Female; Genetic Techniques; Inbreeding; Intestinal Mucosa; Liver; Lung; Mesocricetus; Methylcholanthrene; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonella typhimurium | 1979 |
3,4,5,3',4'-Pentachlorobiphenyl as a useful inducer for purification of rat liver microsomal cytochrome P448.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats | 1979 |
Reconstituted O-dealkylase systems containing various forms of liver microsomal cytochrome P-450.
Topics: Animals; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Rabbits; Rats; Spectrophotometry | 1979 |
Effect of a single dose of inducers and inhibitors on the rate of synthesis of cytochromes and reductases in liver organelles.
Topics: Aflatoxins; Animals; Chloramphenicol; Cycloheximide; Cytochrome Reductases; Cytochromes; Dactinomycin; Female; Liver; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Rabbits | 1979 |
Studies on the different metabolic pathways of antipyrine in rats: influence of phenobarbital and 3-methylcholanthrene treatment.
Topics: Animals; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Half-Life; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats | 1979 |
Atypical inductive properties of rifampicin.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rifampin; Sleep; Time Factors | 1979 |
Differential mutagenicities of triamino benzenes against Salmonella typhimurium TA98 in the presence of S9 fractions from polychlorinated biphenyls-, phenobarbital- or 3-methylcholanthrene-pretreated rats, hamsters and mice.
Topics: Aniline Hydroxylase; Animals; Benzene Derivatives; Cricetinae; Cytochrome P-450 Enzyme System; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Rats; Salmonella typhimurium; Subcellular Fractions | 1979 |
Further studies on the mechanism of the carbon tetrachloride induced polysome breakdown.
Topics: Age Factors; Amitrole; Animals; Carbon Tetrachloride; Cycloheximide; In Vitro Techniques; Liver; Male; Malonates; Methylcholanthrene; Mice; Mice, Inbred A; Niacinamide; Phenobarbital; Polyribosomes; Proadifen; Pyrazoles; Rats | 1976 |
A comparative study on the influence of cysteamine and metyrapone on mixed-function oxygenase activities in variously pretreated liver microsomes from rats and mice.
Topics: Acetanilides; Animals; Cysteamine; Disulfides; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Niacinamide; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1977 |
Relationship between bile flow and Na+, K+-adenosinetriphosphatase in liver plasma membranes enriched in bile canaliculi.
Topics: Adenosine Triphosphatases; Animals; Bile; Body Weight; Cell Membrane; Enzyme Activation; Ethinyl Estradiol; Gallbladder; Liver; Male; Methylcholanthrene; Microscopy, Electron; Organ Size; Phenobarbital; Potassium; Propylene Glycols; Rats; Sodium | 1977 |
Repressible and inducible enzymic forms of dimethylnitrosamine-demethylase.
Topics: Animals; Dimethylnitrosamine; Enzyme Induction; Enzyme Repression; Humans; Liver; Methylcholanthrene; Mice; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Structure-Activity Relationship | 1977 |
Hepatic and extrahepatic induction of drug-metabolizing enzymes in specific pathogen free and germ free rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethyl Ethers; Germ-Free Life; Glucuronosyltransferase; Intestinal Mucosa; Kidney; Liver; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Oxidoreductases, O-Demethylating; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Specific Pathogen-Free Organisms | 1979 |
Pharmacological reversal of cholestasis-associated decrease in hepatic cytochrome P-450.
Topics: Animals; Bile Ducts; Cholestasis; Cytochrome P-450 Enzyme System; Depression, Chemical; Ethinyl Estradiol; Glucose-6-Phosphatase; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats | 1975 |
Optical and electron paramagnetic resonance studies of partially purified rabbit liver cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Electron Spin Resonance Spectroscopy; Hexobarbital; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Spectrum Analysis | 1975 |
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Topics: Animals; Buffers; Carcinoma, Hepatocellular; Cholesterol; Cholestyramine Resin; Cyanides; Cytochrome c Group; Diphosphates; Edetic Acid; Liver; Liver Neoplasms; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Neoplasms, Experimental; Phenobarbital; Phosphates; Rats; Steroid Hydroxylases; Sterols | 1976 |
Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases.
Topics: Animals; Benzopyrene Hydroxylase; Carboxy-Lyases; Cyclic AMP; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Ethylmorphine-N-Demethylase; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Ornithine Decarboxylase; Oxidoreductases; Phenobarbital; Phosphoric Diester Hydrolases; Protein Kinases; Rats | 1976 |
Receptors for morphine and opioids.
Topics: Age Factors; Animals; Dealkylation; Glucuronosyltransferase; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Nalorphine; Nitrophenols; Phenobarbital; Rats; Receptors, Opioid; Time Factors | 1976 |
The induction of hepatic microsomal metabolism in rats following acute administration of a mixture of polybrominated biphenyls.
Topics: Animals; Biphenyl Compounds; Body Weight; Enzyme Induction; Female; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polybrominated Biphenyls; Rats; Time Factors | 1976 |
A comparison of steroid glucuronlytransferases of rat liver and hepatoma, and effects of phenobarbitone and 3-methylcholanthrene induction.
Topics: Animals; Carcinoma, Hepatocellular; Enzyme Induction; Estradiol; Estrone; Glucuronosyltransferase; Kinetics; Liver Neoplasms; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred ACI; Testosterone | 1976 |
Reduced nicotinamide adenine dinucleotide-dependent reduction of tertiary amine N-oxide by liver microsomal cytochrome P-450.
Topics: Amines; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Female; Flavin Mononucleotide; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Oxides; Phenobarbital; Rats; Subtilisins; Trypsin | 1977 |
Correlation of induced drug metabolism with titer of duck hepatitis virus in chickens.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chickens; Cytochrome P-450 Enzyme System; Enterovirus; Enterovirus Infections; Enzyme Induction; Hepatitis Virus, Duck; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital | 1977 |
Enhanced disappearance of drugs from plasma following polybrominated biphenyls.
Topics: Animals; Biphenyl Compounds; Body Weight; Female; Indocyanine Green; Liver; Methylcholanthrene; Mice; Organ Size; Ouabain; Phenobarbital; Polybrominated Biphenyls; Time Factors | 1977 |
Studies of the unique nature of the cytochrome P-450 active site. Electron spin resonance spectroscopy as a probe of the hemin iron of cytochrome P-450: the influence of buffer composition, alcohols, and nitrogenous ligands.
Topics: Alkanesulfonates; Animals; Binding Sites; Buffers; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Hemin; Male; Membranes; Methanol; Methylcholanthrene; Metyrapone; Microsomes, Liver; Morpholines; Phenobarbital; Pseudomonas; Rats | 1977 |
Microsomal activation of estrogens and binding to nucleic acids and proteins.
Topics: Animals; Cytochromes; DNA; Estradiol; Estrogens; Estrone; Guanosine Monophosphate; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Poly G; Rats | 1977 |
Effect of polybrominated biphenyls on bromobenzene lethality in mice.
Topics: Animals; Biphenyl Compounds; Bromobenzenes; Drug Interactions; Female; Glutathione; Lethal Dose 50; Liver; Methylcholanthrene; Mice; Phenobarbital; Polybrominated Biphenyls; Time Factors | 1977 |
Characterization of microsomal electron transport components from control, phenobarbital- and 3-methylcholanthrene-treated mice. II. Improved resolution and quantitation of major components in ammonium sulfate fractions from total liver microsomes.
Topics: Ammonium Sulfate; Animals; Carbon Monoxide; Chemical Fractionation; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Electron Transport; Hemeproteins; In Vitro Techniques; Membrane Proteins; Methylcholanthrene; Mice; Microsomes, Liver; Molecular Weight; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Solubility | 1977 |
Further evidence of cyclic AMP-mediated hypertrophy as a prerequisite of drug-specific enzyme induction.
Topics: Animals; Cyclic AMP; Enzyme Induction; Hypertrophy; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ornithine Decarboxylase; Phenobarbital; Protein Kinases; Proteins; RNA Polymerase I; Time Factors | 1978 |
Correlation of type I, type II, and reverse type I difference spectra with absolute changes in spin state of hepatic microsomal cytochrome P-450 iron from five mammalian species.
Topics: Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Guinea Pigs; Kinetics; Mathematics; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Protein Conformation; Rabbits; Species Specificity; Spectrophotometry | 1978 |
Spectral evidence for weak ligand in sixth position of hepatic microsomal cytochrome P-450 low spin ferric iron in vivo.
Topics: Amines; Animals; Butanols; Cricetinae; Cyclohexanes; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Ferric Compounds; Flavonoids; Guinea Pigs; Iron; Ligands; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Species Specificity; Spectrophotometry | 1978 |
Properties of enzyme systems involved in the formation of catechol estrogen glutathione conjugates in rat liver microsomes.
Topics: Animals; Carbon Monoxide; Catechols; Estrogens; Glutathione; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxygen Consumption; Phenobarbital; Rats; Time Factors | 1978 |
Inducibility of the hepatic drug-metabolizing capacity of mice infected with Schistosoma mansoni.
Topics: Animals; Biotransformation; Cytochromes; Female; Glucose-6-Phosphatase; Liver; Liver Diseases, Parasitic; Methylcholanthrene; Mice; Microsomes, Liver; Pharmaceutical Preparations; Phenobarbital; Schistosoma mansoni; Schistosomiasis | 1978 |
2,4,5,3',4',5'-Hexabromobiphenyl is both a 3-methylcholanthrene-and a phenobarbital-type inducer of microsomal drug metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrene Hydroxylase; Biphenyl Compounds; Cytochrome Reductases; Enzyme Induction; Epoxide Hydrolases; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polybrominated Biphenyls; Rats | 1978 |
Effects of 2,2'-dibromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl on liver microsomal drug metabolizing enzymes.
Topics: Animals; Biphenyl Compounds; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Polybrominated Biphenyls; Proteins; Rats | 1979 |
The structure-activity relationships of halogenated biphenyls as enzyme inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Isomerism; Liver; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Polybrominated Biphenyls; Polychlorinated Biphenyls; Rats; Structure-Activity Relationship | 1979 |
Effect of microsomal preparations and induction on cytochrome P-450-dependent monooxygenases in fetal and neonatal rat liver.
Topics: Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Glucose-6-Phosphatase; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnancy; Rats | 1979 |
Binding of nitrosamines to cytochrome P-450 of liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Kinetics; Ligands; Male; Methylcholanthrene; Mice; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Spectrum Analysis | 1979 |
Spin state transitions of liver microsomal cytochrome P-450.
Topics: Animals; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone; Protein Binding; Rats; Spectrophotometry | 1979 |
Comparison of microsomal and solubilized monooxygenases from rat and rabbit by proton magnetic relaxation.
Topics: Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Iron; Kinetics; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Nitric Oxide; Oxygenases; Phenobarbital; Rabbits; Rats; Solubility; Species Specificity; Temperature | 1979 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
Biphenyl hydroxylations and spectrally apparent interactions with liver microsomes from hamsters pre-treated with phenobarbitone and 3-methylcholanthrene.
Topics: Alcohols; Animals; Biphenyl Compounds; Carbon Radioisotopes; Cricetinae; Cytochrome P-450 Enzyme System; Cytochromes; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Phenobarbital | 1975 |
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Antioxidants; Castration; Dietary Proteins; Electron Transport; Haplorhini; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Selenium; Time Factors; Vitamin E; Vitamin E Deficiency | 1975 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Aryl hydrocarbon hydroxylase in liver nuclei of C3H/He and DBA/2 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Cyclohexanes; Endoplasmic Reticulum; Epoxide Hydrolases; Female; Flavonoids; Glucose-6-Phosphatase; Liver; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Microsomes, Liver; NAD; NADP; Niacinamide; Nucleotidases; Phenobarbital; Propane | 1975 |
The p-hydroxylation of amphetamine and phentermine by rat liver microsomes.
Topics: Amphetamine; Aniline Hydroxylase; Animals; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Phentermine; Rats | 1975 |
Influence of drugs on activation and inactivation of hepatocarcinogenic nitrosamines.
Topics: Alkylation; Animals; Biotransformation; Carcinogens; DNA; Liver Neoplasms; Male; Methylcholanthrene; Mice; Nitrosamines; Oxidation-Reduction; Phenobarbital; Proteins; RNA | 1979 |
Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines.
Topics: Acetonitriles; Animals; Azaguanine; Cell Line; Cell Survival; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Drug Resistance; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Rats; Salmonella typhimurium | 1977 |
Chronic ethanol administration induces a form of cytochrome P-450 with specific spectral and catalytic properties.
Topics: Aniline Compounds; Animals; Catalysis; Cytochrome P-450 Enzyme System; Ethanol; Female; Hydroxylation; Kinetics; Methylation; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1977 |
Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene.
Topics: Animals; Benzopyrenes; Biotransformation; Epoxide Hydrolases; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Mutation; Phenobarbital; Salmonella typhimurium | 1977 |
Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites.
Topics: Animals; Benzopyrenes; Biotransformation; Coumarins; Epoxide Hydrolases; Female; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Mutagens; Oxidoreductases; Phenobarbital; Rats; Salmonella typhimurium; Species Specificity | 1977 |
Metabolic activation of aflatoxins related to their mutagenicity.
Topics: Aflatoxins; Animals; Biotransformation; DNA; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Phenobarbital; Rats; Salmonella typhimurium; Structure-Activity Relationship | 1978 |
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Methylcholanthrene; Mice; Microsomes; Oxidoreductases; Phenobarbital; Premedication; Proadifen; Rauscher Virus; Spleen; Tegafur | 1979 |
Induction of hepatic mono-oxygenase systems in fetal and neonatal rats with phenobarbital, polycylic hydrocarbons and other xenobiotics.
Topics: Aminopyrine N-Demethylase; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Fetus; Hemeproteins; Liver; Maternal-Fetal Exchange; Methylcholanthrene; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Polycyclic Compounds; Pregnancy; Rats | 1977 |
Induction of hepatic mono-oxygenase systems of pregnant rats with phenobarbital and 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Binding Sites; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Hemeproteins; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnancy; Progesterone; Rats | 1977 |
Comparative alterations in extrahepatic drug metabolism by factors known to affect hepatic activity.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Rabbits; Rats; Starvation | 1977 |
Separation and purification of multiple forms of microsomal cytochrome P-450. Activities of different forms of cytochrome P-450 towards several compounds of environmental interest.
Topics: Aflatoxins; Animals; Benzopyrenes; Benzphetamine; Carbamates; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Furans; Lung; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; p-Aminoazobenzene; p-Dimethylaminoazobenzene; Parathion; Phenobarbital; Pyrrolizidine Alkaloids; Rabbits; Rats; Terpenes; Toxins, Biological | 1977 |
Effects of linoleic acid hydroperoxide on the hepatic monooxygenase systems of microsomes from untreated, phenobarbital-treated, and 3-methylcholanthrene-treated rats.
Topics: Animals; Cytochrome Reductases; Drug Interactions; Glutathione; Heme; Hemeproteins; In Vitro Techniques; Linoleic Acids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Temperature; Time Factors | 1977 |
Properties of purified liver microsomal cytochrome P450 from rats treated with the polychlorinated biphenyl mixture Aroclor 1254.
Topics: Animals; Antibodies; Antibody Specificity; Aroclors; Catalysis; Cross Reactions; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Immunodiffusion; Light; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry | 1977 |
Separation and partial purification of two differentially inducible UDP-glucuronyltransferases from rat liver.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; In Vitro Techniques; Methods; Methylcholanthrene; Microsomes, Liver; Morphine; Naphthols; Phenobarbital; Rats | 1977 |
The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Carcinoma; Dose-Response Relationship, Drug; Estradiol; Female; Flavonoids; Methylcholanthrene; Mice; Neoplasms, Experimental; Papilloma; Phenobarbital; Rats; Skin; Skin Neoplasms; Testosterone | 1977 |
Heterogeneity of cytochrome P-450s induced by polychlorinated biphenyls.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry | 1977 |
The inducing properties of polychlorinated biphenyls on hepatic monooxygenases.
Topics: Animals; Aroclors; Cytochromes; Dactinomycin; Enzyme Induction; Female; In Vitro Techniques; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Pregnancy; Rats | 1977 |
Rate-limiting step in the reconstituted microsomal drug hydroxylase system.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits; Spectrophotometry | 1977 |
[Diphenylhydantoin as an inducer for mutation test (author's transl)].
Topics: Animals; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Mutation; Phenobarbital; Phenytoin; Polychlorinated Biphenyls; Rats | 1977 |
Effects of phenobarbital and 3-methylcholanthrene pretreatment on size, sedimentation velocity, and mixed function oxygenase activity of rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Gravitation; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats | 1978 |
Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Kinetics; Male; Membranes; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats | 1978 |
Effect of mixed-function oxidase modifiers on metabolism and toxicity of the oncogen dioxane.
Topics: Animals; Aroclors; Dioxanes; Dioxins; Enzyme Induction; Enzyme Inhibitors; Ethylamines; Lethal Dose 50; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Rats | 1978 |
Comparison of phenobarbital- and carcinogen-induced aldehyde dehydrogenases in the rat.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Benzopyrenes; Carcinogens; Chrysenes; Cytoplasm; Enzyme Induction; Female; Intestinal Mucosa; Liver; Methylcholanthrene; Mitochondria; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Urethane | 1979 |
Characteristics of benzo(a)pyrene metabolism by kidney, liver and lung microsomal fractions from rodents and humans.
Topics: Animals; Benzopyrenes; Cricetinae; Humans; In Vitro Techniques; Kidney; Kinetics; Lung; Male; Mesocricetus; Methylcholanthrene; Microsomes; Microsomes, Liver; Organ Specificity; Phenobarbital; Rats | 1979 |
Rat hepatic nuclear cytochrome P-450 and epoxide hydrase in membranes prepared by two methods: similarities with the microsomal enzymes.
Topics: Animals; Cell Nucleus; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme System; Deoxyribonucleases; Enzyme Induction; Epoxide Hydrolases; In Vitro Techniques; Intracellular Membranes; Liver; Male; Methods; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1979 |
Effects of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes.
Topics: Animals; Biological Transport, Active; Enzyme Induction; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Procainamide; Rats; Taurocholic Acid | 1979 |
Iodipamide hepatotoxicity in the rat.
Topics: Age Factors; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fasting; Iodipamide; Kidney; Liver; Male; Methylcholanthrene; Necrosis; Phenobarbital; Premedication; Rats; Selenium | 1979 |
Dantrolene inhibition of the hepatic mixed function oxidase system.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Dantrolene; Ethylmorphine-N-Demethylase; Hexobarbital; Hydantoins; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1979 |
Formation of benzo[a]pyrene metabolite-nucleoside adducts in isolated perfused rat and mouse liver and in mouse lung slices.
Topics: Animals; Benzopyrenes; Carcinogens; Cytochrome P-450 Enzyme System; Deoxyribonucleosides; DNA; Enzyme Induction; Epoxy Compounds; In Vitro Techniques; Liver; Lung; Male; Methylcholanthrene; Mice; Perfusion; Phenobarbital; Rats; Ribonucleosides; RNA | 1979 |
Bile flow in response to pharmacologic agents. Hepatic DNA as a reference standard.
Topics: Animals; Bile; Body Weight; DNA; Ethinyl Estradiol; Liver; Male; Methylcholanthrene; Methylprednisolone; Organ Size; Phenobarbital; Rats | 1979 |
Interaction of isosafrole in vivo with rat hepatic microsomal cytochrome P-450 following treatment with phenobarbitone or 20-methylcholanthrene.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Drug Interactions; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole | 1979 |
Suppression of the inductive effects of phenobarbital and 3-methylcholanthrene on ascorbic acid synthesis and hepatic cytochrome P-450-linked monooxygenase systems by the interferon inducers, poly rI.rC and tilorone.
Topics: Animals; Ascorbic Acid; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Fluorenes; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Poly I-C; Rats; Tilorone | 1979 |
Circular dichroism spectra of purified cytochromes P-450 from rabbit liver microsomes.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Conformation; Rabbits | 1979 |
Mutagenesis of certain benzo(a)pyrene phenols in vitro following further metabolism by mouse liver.
Topics: Animals; Benzopyrenes; In Vitro Techniques; Liver; Methylcholanthrene; Mice; Mutagens; Phenobarbital; Phenols | 1979 |
Styrene induced modifications of some rat liver enzymes involved in the activation and inactivation of xenobiotics.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Mutagens; Pharmaceutical Preparations; Phenobarbital; Rats; Styrenes; Subcellular Fractions | 1979 |
Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes.
Topics: Aniline Compounds; Animals; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Hexobarbital; Hydrocarbons, Chlorinated; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1979 |
A comparison of xenobiotic metabolism in cells isolated from rat liver and small intestinal mucosa.
Topics: Aniline Compounds; Animals; Benzoates; Biotransformation; Coumarins; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Liver; Male; Methylcholanthrene; Phenobarbital; Phenols; Rats; Time Factors | 1979 |
Cholestasis as an in vivo model for analysis of the induction of liver microsomal monooxygenases by sodium phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cholestasis; Deoxycholic Acid; Enzyme Induction; In Vitro Techniques; Kinetics; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Models, Biological; Oxidoreductases; Oxygen Consumption; Peroxides; Phenobarbital; Rats | 1979 |
The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro.
Topics: Animals; Carbon Monoxide; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyridines; Rabbits | 1979 |
Induction of disopyramide N-dealkylation by phenobarbital and disopyramide in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Disopyramide; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH Dehydrogenase; Phenobarbital; Pyridines; Rats | 1979 |
Regulation of rat liver epoxide hydratase activity by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Epoxide Hydrolases; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1979 |
The metabolism of 4-methoxy-beta-choloro styrene by liver microsomal monooxygenases.
Topics: Animals; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Protein Binding; Rats; Styrenes | 1979 |
Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Oxidoreductases; Phenobarbital; Proadifen; Rats | 1979 |
Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms.
Topics: Amino Acids; Animals; Epoxide Hydrolases; Humans; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Stilbenes | 1979 |
Hepatic microsomal epoxidation of bromobenzene to phenols and its toxicological implication.
Topics: Animals; Bromobenzenes; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethers, Cyclic; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Phenols; Rats; Sodium Fluoride | 1979 |
Comparison of nuclear and microsomal epoxide hydrase from rat liver.
Topics: Animals; Cell Fractionation; Cell Nucleus; Enzyme Induction; Epoxide Hydrolases; Liver; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxides; Phenobarbital; Rats; Substrate Specificity | 1979 |
Microsomal biophenyl hydroxylation: the effect of selective deuterium substitution on the rate of formation of the monohydroxybiphenyls [proceedings].
Topics: Animals; Biphenyl Compounds; Deuterium; Hydroxylation; Isotope Labeling; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Substrate Specificity | 1979 |
A preliminary structure-activity study of the mixed-function oxidase inhibitor 7,8-benzoflavone.
Topics: Animals; Benzoflavones; Benzopyrene Hydroxylase; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Structure-Activity Relationship | 1979 |
Properties of estradiol 2-hydroxylase and 2-hydroxy-3-deoxyestradiol 3-hydroxylase in rat liver.
Topics: Animals; Carbon Monoxide; Cold Temperature; Estradiol; Estrogens; Light; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen; Oxygen; Phenobarbital; Rats; Steroid Hydroxylases | 1979 |
Modifications of benzene myelotoxicity and metabolism by phenobarbital, SKF-525A and 3-methylcholanthrene.
Topics: Animals; Benzene; Leukocytosis; Leukopenia; Male; Methylcholanthrene; Phenobarbital; Phenols; Proadifen; Rats | 1979 |
Infrared spectral studies of carbon monoxide complexes of microsomal cytochromes P-450 and P-448.
Topics: Animals; Camphor; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrophotometry, Infrared | 1979 |
Effects of phenobarbital and 3-methylcholanthrene pretreatment on the plasma half-life and urinary excretion profile of theophylline and its metabolites in rats.
Topics: Animals; Biotransformation; Feces; Half-Life; Male; Methylcholanthrene; Phenobarbital; Rats; Theophylline; Time Factors | 1979 |
Use of a dimethylated oxirane to characterise microsomal mono-oxygenases in rat liver.
Topics: Aging; Animals; Dieldrin; Enzyme Induction; Female; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1979 |
Induction by phenobarbitone or 3-methylcholanthrene of the hepatic microsomal metabolism of harmine [proceedings].
Topics: Alkaloids; Animals; Harmine; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital | 1979 |
Binding of reactive metabolites of aromatic hydrocarbons to specific microsomal proteins.
Topics: Animals; Benzopyrenes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats | 1979 |
Genetic control of responsiveness of rat liver supernatant aldehyde dehydrogenase to phenobarbital and 3-methylcholanthrene.
Topics: Aldehyde Oxidoreductases; Animals; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1979 |
Comparison of hepatic microsomal enzyme induction by methadone, phenobarbital and 3-methylcholanthrene in the mouse.
Topics: Animals; Enzyme Induction; In Vitro Techniques; Male; Methadone; Methylcholanthrene; Mice; Mice, Inbred ICR; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Sleep | 1979 |
Effect of alpha-tocopherol on the binding of benzo(a)pyrene to nuclear macromolecules.
Topics: Animals; Benzopyrenes; Cell Nucleus; Dose-Response Relationship, Drug; Liver; Macromolecular Substances; Male; Methylcholanthrene; Microsomes, Liver; Nuclear Envelope; Phenobarbital; Rats; Subcellular Fractions; Vitamin E | 1979 |
Rat liver microsome-mediated N-demethylation and mutagenicity of azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Benzoflavones; Biotransformation; Chlorides; Cobalt; Diet; Disulfiram; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats | 1978 |
Anthracene 1,2-oxide: synthesis and role in the metabolism of anthracene by mammals.
Topics: Animals; Anthracenes; Epoxide Hydrolases; Male; Methylcholanthrene; Microsomes, Liver; Oxides; Phenobarbital; Rats | 1979 |
The metabolism of benzo(a)pyrene in isolated perfused lungs from variously-treated rats.
Topics: Animals; Benzopyrenes; Half-Life; Lung; Male; Methylcholanthrene; Mixed Function Oxygenases; Nicotiana; Perfusion; Phenobarbital; Plants, Toxic; Rats; Smoke | 1977 |
SDS-polyacylamide gel electrophoresis of hepatic cytochrome P-450 from normal, 3-methylcholanthrene and phenobarbital treated mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Male; Methods; Methylcholanthrene; Mice; Microsomes, Liver; Molecular Weight; Phenobarbital; Sodium Dodecyl Sulfate | 1977 |
The effects of nitrofuran derivatives on hepatic microsomal mixed-function oxidase activity in rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Female; Furylfuramide; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrofurans; Organ Size; Oxidoreductases; Pentobarbital; Phenobarbital; Rats; Sleep | 1977 |
Qualitative alteration in hepatic microsomal cytochrome P-450 apoproteins associated with bile duct ligation, and the administration of ethinyl estradiol, phenobarbital and 3-methylcholanthrene.
Topics: Animals; Apoproteins; Common Bile Duct; Cytochrome P-450 Enzyme System; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Ethinyl Estradiol; Ligation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1978 |
Induction of cytochrome P-450 by halogenated benzenes.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrocarbons, Halogenated; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1978 |
A novel haemoprotein induced by isosafrole pretreatment in the rat.
Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole; Spectrum Analysis | 1978 |
The effect of phenobarbitone on cytoplasmic NADP-linked dehydrogenase activities in rat liver.
Topics: Animals; Cytoplasm; Dietary Carbohydrates; Fasting; Female; Glucosephosphate Dehydrogenase; Liver; Malate Dehydrogenase; Methylcholanthrene; NADH, NADPH Oxidoreductases; Pentosephosphates; Phenobarbital; Rats; Sucrose | 1978 |
Studies on the binding of [3H-chloroethyl]-cyclophosphamide and 14[C-4] -cyclophosphamide to hepatic microsomes and native calf thymus DNA.
Topics: Animals; Binding Sites; Cattle; Cyclophosphamide; Cysteine; DNA; Glutathione; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Semicarbazides; Thymus Gland | 1978 |
The stereoselective metabolism of ethylamphetamine with fortified rabbit liver homogenates.
Topics: Amphetamines; Animals; Biotransformation; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Phenobarbital; Rabbits; Stereoisomerism; Structure-Activity Relationship; Time Factors | 1978 |
Covalent binding of the carcinogen trichloroethylene to hepatic microsomal proteins and to exogenous DNA in vitro.
Topics: Animals; DNA; Female; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Organ Specificity; Phenobarbital; Proteins; Rats; Sex Factors; Species Specificity; Trichloroethylene | 1978 |
Effect of agents known to alter carbon tetrachloride hepatotoxicity and cytochrome P-450 levels on carbon tetrachloride-stimulated lipid peroxidation and ethane expiration in the intact rat.
Topics: 1-Propanol; Animals; Breath Tests; Carbon Tetrachloride; Cobalt; Drug Interactions; Ethane; Ethanol; Lipid Metabolism; Male; Maleates; Methylcholanthrene; Peroxides; Phenobarbital; Rats | 1978 |
Metabolism of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene by rat liver nuclei and microsomes.
Topics: Animals; Benzopyrenes; Cell Nucleus; Dihydroxydihydrobenzopyrenes; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nuclear Envelope; Phenobarbital; Rats | 1978 |
Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Liver; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Nuclear Envelope; Phenobarbital; Rats; Spectrophotometry | 1978 |
The role of substrate lipophilicity in determining type 1 microsomal P450 binding characteristics.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Kinetics; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Solubility | 1978 |
An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coumarins; Dioxins; Enzyme Induction; Ethyl Ethers; Kinetics; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oxygenases; Phenobarbital; Polychlorinated Dibenzodioxins; Spectrometry, Fluorescence | 1978 |
Chemical induction of p-aminohippuric acid transport in renal cortical slices from adult and immature rabbits.
Topics: Aging; Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidney Cortex; Methylcholanthrene; Microsomes; p-Aminohippuric Acid; Penicillin G Procaine; Phenobarbital; Rabbits; Stimulation, Chemical | 1978 |
In vitro drug metabolism in male and female athymic, nude mice.
Topics: Animals; Female; Genotype; In Vitro Techniques; Liver; Male; Methylcholanthrene; Mice; Mice, Nude; Pharmaceutical Preparations; Phenobarbital; Sex Factors; Subcellular Fractions | 1978 |
Rapid stimulation of hepatic microsomal heme oxygenase in selenium-deficient rats. An effect of phenobarbital.
Topics: 5-Aminolevulinate Synthetase; Animals; Enzyme Induction; Heme; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Selenium | 1978 |
Long-term reduction of brain serotonin by p-chloroamphetamine: effects of inducers and inhibitors of drug metabolism.
Topics: Amphetamines; Animals; Brain; Brain Chemistry; Depression, Chemical; Half-Life; Male; Methylcholanthrene; Microsomes, Liver; p-Chloroamphetamine; Phenobarbital; Piperonyl Butoxide; Propylamines; Rats; Serotonin; Serotonin Antagonists; Synaptosomes; Tryptophan Hydroxylase | 1978 |
The effects of dantrolene sodium on excretory function in the isolated perfused rat liver.
Topics: Animals; Aspartate Aminotransferases; Bile; Bile Acids and Salts; Dantrolene; Hydantoins; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Sulfobromophthalein | 1978 |
Comparison of highly-purified microsomal cytochromes P-450 and NADPH-cytochrome P-450 reductases by peptide mapping.
Topics: Animals; Chymotrypsin; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Methylcholanthrene; Microsomes, Liver; Papain; Peptide Fragments; Peptide Hydrolases; Phenobarbital; Rabbits; Rats; Staphylococcus aureus | 1978 |
Induction of rat liver cytosol methyl red azo-reductase by 3-methylcholanthrene assayed by a sensitive fluorometric method.
Topics: Animals; Azo Compounds; Cytosol; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Rats; Spectrometry, Fluorescence | 1978 |
Microsomal metabolism of arylamides by the rat and guinea pig--I. Oxidation of N-3-fluorenylacetamide at carbon-atom-9--a major metabolic reaction.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Fluorenes; Guinea Pigs; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1978 |
Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat.
Topics: Animals; Benzopyrenes; Diet; Enzyme Induction; Glutathione Transferase; Intestine, Small; Kidney; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1978 |
The mechanism of action of cytochrome P-450. Occurrence of the 'NIH shift' during hydroperoxide-dependent aromatic hydroxylations.
Topics: Acetanilides; Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Cytochromes; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Peroxides; Phenobarbital; Rabbits; Rats | 1978 |
Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Flavonoids; Hydroxylation; Isomerism; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Phenobarbital; Rabbits; Structure-Activity Relationship; Warfarin | 1978 |
Effect of alteration of rat hepatic mixed-function oxidase (MFO) activity on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Castration; Cobalt; Dioxins; Female; Hemin; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Testosterone | 1978 |
The role of lipid components of the diet in the regulation of the fatty acid composition of the rat liver endoplasmic reticulum and lipid peroxidation.
Topics: Animals; Antioxidants; Dietary Fats; Endoplasmic Reticulum; Fatty Acids; Lipid Metabolism; Liver; Male; Methylcholanthrene; Microsomes, Liver; Peroxides; Phenobarbital; Rats | 1978 |
Studies on the hepatic microsomal metabolism of (14C) phenanthrene.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Methylcholanthrene; Mice; Mice, Inbred DBA; Microsomes, Liver; Phenanthrenes; Phenobarbital; Rats; Species Specificity | 1978 |
Biphenyl metabolism in isolated rat hepatocytes: effect of induction and nature of the conjugates.
Topics: Animals; Biphenyl Compounds; Chromatography, High Pressure Liquid; Enzyme Induction; Hydroxylation; Hymecromone; In Vitro Techniques; Liver; Methylcholanthrene; Phenobarbital; Rats; Time Factors | 1978 |
Is steroid-16alpha-hydroxylase supported by more than one monooxygenase?
Topics: Animals; Female; Flavonoids; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Naphthalenes; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Sex Factors; Steroid Hydroxylases | 1978 |
Studies on the cytochrome P-450 product complexes formed during the metabolism of N,N-dimethylaniline.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Deoxycholic Acid; Female; Ferricyanides; Liposomes; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rabbits; Spectrophotometry | 1978 |
Modulation of the binding of the carcinogen benzo(a)pyrene to rat liver DNA in vivo by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Dieldrin; DNA; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1978 |
Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cell Nucleus; Dieldrin; Enzyme Induction; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Time Factors | 1978 |
The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol.
Topics: Animals; Cytosol; Dioxins; Glutathione Transferase; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats | 1978 |
Resonance Raman studies of hepatic microsomal cytochromes P-450: evidence for strong pi basicity of the fifth ligand in the reduced and carbonyl complex forms.
Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Hemeproteins; Ligands; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Conformation; Rabbits; Spectrum Analysis, Raman | 1978 |
A comparison of the in vitro metabolism of biphenyl and 4-chlorobiphenyl by rat liver microsomes.
Topics: Animals; Aroclors; Benzopyrenes; Biphenyl Compounds; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1978 |
Interaction of styrene and acetone with drug biotransformation enzymes in rat liver.
Topics: Acetone; Animals; Binding Sites; Biotransformation; Cytochrome P-450 Enzyme System; Drug Interactions; Endoplasmic Reticulum; Glutathione; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Styrenes; Sulfhydryl Compounds | 1978 |
Immunohistochemical localizations of cytochromes P-450 in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Histocytochemistry; Immunochemistry; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1978 |
Inactivation of N-methyl-N'-nitro-N-nitrosoguanidine in the Ames Salmonella/microsome test.
Topics: Animals; Aroclors; Methods; Methylcholanthrene; Methylnitronitrosoguanidine; Microsomes, Liver; Mutation; Phenobarbital; Rats; Salmonella; Structure-Activity Relationship | 1978 |
Effect of the Tfm locus on the hepatic ethylmorphine N-demethylase system in mice.
Topics: Androgens; Animals; Castration; Cytochrome P-450 Enzyme System; Dihydrotestosterone; Drug Resistance; Enzyme Induction; Estradiol; Ethylmorphine-N-Demethylase; Female; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Progesterone Congeners; Receptors, Androgen; Receptors, Steroid; Sex Factors; Testosterone | 1978 |
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine | 1978 |
Effects of age, inducing agents and carcinogens on the distribution of cytochrome P-450 in microsomal membranes from rat liver.
Topics: 2-Acetylaminofluorene; Aging; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrum Analysis | 1978 |
Alterations in the toxicity of thiodemeton due to the pretreatment of inducers, substrates and inhibitors of mixed function oxidase system.
Topics: Acetanilides; Aminopyrine; Animals; Cobalt; Cycloheximide; Disulfoton; Enzyme Induction; Ethylmorphine; Female; Insecticides; Male; Methylcholanthrene; Mixed Function Oxygenases; Nickel; Oxidoreductases; Phenobarbital; Rats | 1978 |
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.
Topics: Animals; Glutathione; Glutathione Reductase; Glutathione Transferase; Liver; Lung; Male; Methylcholanthrene; Phenobarbital; Rats | 1979 |
Induction of aryl hydrocarbon hydroxylase by polychlorinated biphenyls in the foeto-placental unit and neonatal livers during lactation.
Topics: Animals; Animals, Newborn; Benzopyrenes; Enzyme Induction; Female; Lactation; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Placenta; Polychlorinated Biphenyls; Pregnancy; Rats | 1975 |
Comparative effect of phenobarbital and 3-methyl-cholanthrene on azodye metabolism in rat liver. I. In vitro studies on detoxication and activation processes.
Topics: Animals; Body Weight; Cytochromes; DNA; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidoreductases; p-Dimethylaminoazobenzene; Phenobarbital; Protein Binding; Rats; Thymus Gland; Time Factors | 1975 |
The effect of some inducers of hepatic xenobiotic-metabolizing enzymes on the urinary excretion of D-glucuronic acid metabolites in the rat.
Topics: Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Glucuronates; Glucuronosyltransferase; Hymecromone; Insecticides; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone; Rats; Time Factors; Toluene | 1975 |
Metobolism of chlorobenzene with hepatic microsomes and solubilized cytochrome P-450 systems.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Edetic Acid; Hemeproteins; Isomerism; Methylcholanthrene; Microsomes, Liver; Perfusion; Phenobarbital; Rats; Solubility | 1975 |
Comparative effect of phenobarbital and 3-methylcholanthrene on azo dye metabolism in rat liver. II. In vivo binding of metabolites to cellular macromolecules.
Topics: Administration, Oral; Animals; Carbon Radioisotopes; Depression, Chemical; DNA; Injections, Intraperitoneal; Liver; Male; Methylcholanthrene; p-Dimethylaminoazobenzene; Phenobarbital; Proteins; Rats; Stimulation, Chemical | 1975 |
Multiplicity of cytochrome P-450 hemoproteins in rat liver microsomes. Preparation and specificity of an antibody to the hemoprotein induced by phenobarbital.
Topics: Agglutination Tests; Animals; Antigen-Antibody Reactions; Chromatography, Gel; Complement Fixation Tests; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Hemeproteins; Immunodiffusion; Iodine Radioisotopes; Liver; Male; Methylcholanthrene; Microsomes; Molecular Weight; Phenobarbital; Rabbits; Rats; Sodium Dodecyl Sulfate | 1975 |
Characterization of microsomal electron transport components from control, phenobarbital, and 3-methylcholanthrene treated mice: I. Distribution of electron transport components in ammonium-sulfate fractions from mouse liver microsomes.
Topics: Ammonium Sulfate; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Electrophoresis, Polyacrylamide Gel; Fractional Precipitation; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital | 1975 |
Inhibition of the acute toxicity and adrenocorticolytic effect of 7,12-dimethylbenz(a)anthracene by isopropylvaleramide and allylisopropylacetamide in the rat.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetamides; Adrenal Cortex; Adrenal Glands; Allylisopropylacetamide; Amides; Animals; Barbiturates; Benz(a)Anthracenes; Benzopyrenes; Dimethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Methylcholanthrene; Pentobarbital; Phenobarbital; Proadifen; Rats; Secobarbital; Time Factors; Valerates | 1975 |
Partial purification and separation of multiple forms of cytochrome. P-450 and cytochrome P-448 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Ethane; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Multienzyme Complexes; NADPH-Ferrihemoprotein Reductase; Naphthalenes; Nitriles; Oxidation-Reduction; Phenobarbital; Phosphatidylcholines; Rats; Spectrum Analysis; Surface-Active Agents | 1975 |
Relationship between microsomal hydroxylase and glucuronyltransferase.
Topics: Aminopyrine; Animals; Bilirubin; Biotransformation; Chloramphenicol; Cytochrome P-450 Enzyme System; Deoxycholic Acid; Female; Glucuronosyltransferase; Hexosyltransferases; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Naphthols; Nitrophenols; Phenobarbital; Polyethylene Glycols; Rats; Sex Factors; Sonication | 1975 |
Drug induction of hepatic glutathione S-transferases in male and female rats*.
Topics: Animals; Benzopyrenes; Enzyme Induction; Female; Glutathione Transferase; Haplorhini; Humans; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Polycyclic Compounds; Sex Factors; Transferases | 1975 |
Characterization of a rat lung microsomal fraction obtained by sepharose 2B ultrafiltration.
Topics: Animals; Cell Fractionation; Chromatography, Agarose; Cytochrome P-450 Enzyme System; Cytochromes; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Proadifen; Rats; Spectrum Analysis; Stimulation, Chemical; Ultracentrifugation | 1975 |
Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Crosses, Genetic; Cytochrome P-450 Enzyme System; Female; Genes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Mutagens; Oxygenases; Phenobarbital; Species Specificity | 1975 |
Inducibility of mucosal drug-metabolizing enzymes of rats fed on a cholesterol-rich diet by polychlorinated biphenyl, 3-methylcholanthrene and phenobarbitone.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Enzyme Induction; Glucuronosyltransferase; In Vitro Techniques; Intestinal Mucosa; Male; Methylcholanthrene; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Phospholipids; Polychlorinated Biphenyls; Proteins; Rats; Rats, Inbred Strains | 1975 |
Evidence against multiple forms of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase in rat liver microsomes.
Topics: Animals; Antibodies; Bromelains; Cytochrome Reductases; Electrophoresis, Polyacrylamide Gel; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Precipitin Tests; Rats | 1975 |
[Metabolic studies on polychlorinated biphenyls. VI. Contribution of the hydroxylated metabolites to the acute toxicity of 2,4,3',4'-tetrachlorobiphenyl(author's transl)].
Topics: Animals; Bile; Liver; Male; Methylcholanthrene; Mice; Phenobarbital; Polychlorinated Biphenyls | 1975 |
Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzopyrenes; Binding Sites; Cell Nucleus; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats | 1976 |
Possible mechanism of induction of liver microsomal monooxygenases by phenobarbital.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1976 |
Importance of genetic factors influencing the metabolism of foreign compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Laboratory; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Biotransformation; Drosophila; Enzyme Induction; Genes, Dominant; Genes, Regulator; Genotype; Methylcholanthrene; Mice; Mice, Inbred Strains; Models, Biological; Oxygenases; Phenobarbital; Species Specificity; Zoxazolamine | 1976 |
[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Barbital; Chlorpromazine; Cytochrome P-450 Enzyme System; Lung Neoplasms; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Neoplasms, Experimental; Phenobarbital; Urethane | 1976 |
Modification of microsomal membrane components and induction of hepatic drug biotransformation in rats on a high cholesterol diet.
Topics: Animals; Biotransformation; Cell Membrane; Cholesterol; Cholesterol, Dietary; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Phospholipases; Rats; Trypsin | 1976 |
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes.
Topics: Acetone; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Benzopyrenes; Catechol Oxidase; Cricetinae; Cytochromes; Dactinomycin; Dioxoles; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nikethamide; Phenobarbital; Rats; Safrole | 1976 |
Induction and activation of rat liver microsomal bile salt glucuronyltransferase.
Topics: Animals; Chenodeoxycholic Acid; Cholic Acids; Enzyme Activation; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Lithocholic Acid; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Polyethylene Glycols; Rats | 1976 |
UDP glucuronosyltransferase and mixed function oxidase activity in microsomes prepared by differential centrifugation and calcium aggregation.
Topics: Animals; Benzopyrene Hydroxylase; Calcium; Cytochrome P-450 Enzyme System; Digitonin; Glucuronosyltransferase; Kidney; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Rats; Trypsin; Ultracentrifugation | 1976 |
Pregnenolone-16alpha-carbonitrile-inducible cytochrome P450 in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1976 |
The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.
Topics: Animals; Benzopyrenes; Cell Fractionation; Cytochrome P-450 Enzyme System; Drug Stability; Fasting; Intestine, Small; Kinetics; Male; Methylcholanthrene; Microsomes; NADPH-Ferrihemoprotein Reductase; Oxygenases; Phenobarbital; Rats | 1976 |
Metabolism of naphthalene to naphthalene dihydrodiol glucuronide in isolated hepatocytes and in liver microsomes.
Topics: Animals; Cells, Cultured; Glucuronates; Glucuronosyltransferase; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Naphthols; Phenobarbital; Rats | 1976 |
Allylisopropylacetamide preferentially interacts with the phenobarbital-inducible form of rat hepatic microsomal P-450.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats | 1976 |
Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Crosses, Genetic; Cytosol; Enzyme Induction; Flavonoids; Genetic Variation; Kinetics; Liver; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NADH, NADPH Oxidoreductases; Nitriles; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnenolone; Quinone Reductases; Species Specificity | 1977 |
Interactions between solubilized cytochrome P-450 and hepatic microsomes.
Topics: Animals; Binding Sites; Coumarins; Cytochrome P-450 Enzyme System; Ethyl Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Protein Binding; Rats; Solubility | 1977 |
Stereochemical biotransformation of warfarin as a probe of the homogeneity and mechanism of microsomal hydroxylases.
Topics: Animals; Biotransformation; Cytochromes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proteins; Rats; Stereoisomerism; Time Factors; Warfarin | 1977 |
The glutathione S-transferases of the small intestine in the rat.
Topics: Animals; Benzopyrenes; Carcinogens; Enzyme Induction; Epoxy Compounds; Ethacrynic Acid; Fasting; Glutathione Transferase; Inactivation, Metabolic; Intestine, Small; Kidney; Liver; Male; Methylcholanthrene; Nitrobenzenes; Phenobarbital; Rats | 1977 |
Effect of subacute dosing and phenobarbital and 3-methylcholanthrene pretreatment on the metabolism of acetaminophen in rats.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Phenobarbital; Premedication; Rats | 1977 |
The effects of some tobacco smoke constituents on foreign compound metabolism in the cat and the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Atmosphere; Carbon Monoxide; Catheterization; Cats; Cotinine; Female; Femoral Vein; In Vitro Techniques; Injections, Subcutaneous; Kidney; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Nicotine; Pharmaceutical Preparations; Phenobarbital; Rats; Time Factors | 1977 |
Induction of rat hepatic glutathione S-transferase B by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cytosol; Enzyme Induction; Glutathione Transferase; Immunoassay; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1977 |
Hepatic microsomal epoxide hydrase: a sensitive radiometric assay for hydration of arene oxides of carcinogenic aromatic hydrocarbons.
Topics: Animals; Benzopyrenes; Carcinogens; Epoxide Hydrolases; Hydro-Lyases; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxides; Phenobarbital; Proteins; Rats; Time Factors; Tritium | 1977 |
Differences in benzo(a)pyrene metabolism between lung and liver homogenates.
Topics: Animals; Benzopyrenes; Liver; Lung; Male; Methylcholanthrene; Phenobarbital; Rats | 1977 |
Influence of inducers and inhibitors of mixed-function oxidasts on benzo(a)pyrene binding to the DNA of rat liver nuclei.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Chromatography, Ion Exchange; Ethers, Cyclic; Flavonoids; Hydrocarbons, Chlorinated; In Vitro Techniques; Liver; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1977 |
Inhibition by CO of hepatic benzo[a]pyrene hydroxylation and its reversal by monochromatic light.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Carbon Monoxide; Kinetics; Light; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1977 |
Differential effects of phenobarbital and 3-methylcholanthrene on rat hepatic ribosomal precursor RNA.
Topics: Animals; Cell Nucleolus; Cell Nucleus; Centrifugation, Density Gradient; Cytoplasm; DNA-Directed RNA Polymerases; Liver; Male; Methylcholanthrene; Microsomes, Liver; Orotic Acid; Phenobarbital; Rats; RNA, Ribosomal; Time Factors | 1977 |
Effect of phenobarbital and 3-methylcholanthrene administration on epoxide hydrase levels in liver microsomes.
Topics: Animals; Enzyme Induction; Epoxide Hydrolases; Hydro-Lyases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Time Factors | 1977 |
Steroid glucuronyltransferases of rat liver. Properties of oestrone and testosterone glucuronyltransferases and the effect of ovariectomy, castration and administration of steroids on the enzymes.
Topics: Animals; Bilirubin; Castration; Cycloheximide; Dactinomycin; Detergents; Estradiol; Estrone; Female; Glucuronates; Hexosyltransferases; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Testosterone | 1977 |
Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.
Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Fetus; Flavonoids; Genes, Regulator; In Vitro Techniques; Kidney; Light; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Organ Specificity; Oxygenases; Phenobarbital; Pregnancy; Rabbits; Spectrophotometry; Time Factors | 1977 |
Influence of phenobarbital on factors responsible for hepatic clearance of indocyanine green in the rat: relative contributions of induction and altered liver blood flow.
Topics: Animals; Benzopyrenes; Enzyme Induction; Half-Life; Indocyanine Green; Liver; Liver Circulation; Male; Methylcholanthrene; Phenobarbital; Rats | 1977 |
An improved radiochemical assay for benzo(a)pyrene monooxygenase.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Isotope Labeling; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Tritium | 1977 |
N-Hydroxylation of arylamides by the rat and guinea pig. Evidence for substrate specificity and participation of cytochrome P1-450.
Topics: 2-Acetylaminofluorene; Animals; Bile; Cobalt; Cytochrome P-450 Enzyme System; Female; Fluorenes; Fluorides; Guinea Pigs; Hydroxyacetylaminofluorene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet | 1977 |
[Resistance of different forms of rat liver cytochrome P-450 to influence destabilizing microsomal membranes].
Topics: Animals; Cytochrome P-450 Enzyme System; Deoxycholic Acid; Fatty Acids, Unsaturated; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; Peroxides; Phenobarbital; Phospholipids; Rats | 1977 |
Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.
Topics: Animals; Antibodies; Benzopyrenes; Benzphetamine; Coumarins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; In Vitro Techniques; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Phenobarbital; Rats; Testosterone | 1977 |
The effect of phenobarbital and 3-methylcholanthrene pretreatment on the N-hydroxylation of phentermine.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Drug Interactions; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Phentermine; Rats | 1977 |
Immunochemical studies on a phenobarbital-inducible esterase in rat liver microsomes.
Topics: Amidohydrolases; Animals; Enzyme Induction; Esterases; Female; Immunoelectrophoresis; Kidney; Lung; Membrane Proteins; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Solubility | 1977 |
Microsomal metabolism on benzo(a)pyrene. Multiple effects of epoxide hydrase inhibitors.
Topics: Benzopyrenes; Enzyme Induction; Epoxide Hydrolases; Hydro-Lyases; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital | 1977 |
Binding of R and S warfarin to hepatic microsomal cytochrome P-450.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Warfarin | 1977 |
Metabolism in vivo of dioxane: effect of inducers and inhibitors of hepatic mixed-function oxidases.
Topics: Animals; Aroclors; Dioxanes; Dioxins; Enzyme Induction; Ethylamines; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1977 |
[A substrate-type induction of liver microsomal monooxygenases by phenobarbital].
Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Genotype; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Phenobarbital; Rats | 1977 |
The relative ethylumbelliferone dealkylase activity characterizing the effect of different inducers on the hydroxylase system in the liver microsomes of female mice.
Topics: Animals; Camphor; Cyclohexanes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Female; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Time Factors; Umbelliferones | 1977 |
Binding of polysomes in vitro with endoplasmic membrane prepared from rat liver. II. Possible involvement of cytochrome P-450 in the binding.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Female; Liver; Membranes; Methylcholanthrene; Phenobarbital; Polyribosomes; Rats | 1977 |
In vitro metabolism of aflatoxin B1 by rat liver nuclei.
Topics: Aflatoxins; Animals; Cell Nucleus; DNA; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sialyltransferases | 1977 |
Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene.
Topics: Animals; Caffeine; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Stimulation, Chemical; Time Factors | 1977 |
Properties of a rat liver smooth microsomal subfraction not aggregated by Mg2+.
Topics: Animals; Cell Fractionation; Centrifugation, Density Gradient; Cholesterol; Cytochromes; Hexoses; Lipids; Magnesium; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phospholipids; Proteins; Rats; Solubility | 1976 |
Evidence for the possible formation of a toxic tyrosine metabolite by the liver microsomal drug metabolizing system.
Topics: Animals; Benserazide; Biotransformation; Cobalt; Cysteine; Glutathione; Humans; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Tyrosine | 1976 |
Ethanol-induced cytochrome P-450: catalytic activity after partial purification.
Topics: Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Ethanol; Female; Kinetics; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1976 |
Effect of 7 8-benzoflavone on the duration of zoxazolamine paralysis and hexobarbital hypnosis in rats.
Topics: Animals; Depression, Chemical; Flavonoids; Hexobarbital; Male; Methylcholanthrene; Paralysis; Phenobarbital; Rats; Sleep; Time Factors; Zoxazolamine | 1976 |
Effects of phenobarbital and 3-methylcholanthrene administration on glutathione-S-epoxide transferase activity in rat liver.
Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1976 |
Cytochrome P-450 induction by phenobarbital and 3-methylcholanthrene in primary cultures of hepatocytes.
Topics: Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Liver; Methylcholanthrene; Phenobarbital | 1976 |
Separation and quantitative determination of 2-acetyl-aminofluorene and its hydroxylated metabolites by high pressure liquid chromatography.
Topics: 2-Acetylaminofluorene; Animals; Chromatography, High Pressure Liquid; Fluorenes; Hydroxylation; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Structure-Activity Relationship | 1976 |
Relationship between induction of aryl hydrocarbon hydroxylase and de novo synthesis of cytochrome P-448 (P1-450) in mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cytochrome P-450 Enzyme System; DDT; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Species Specificity | 1976 |
Mouse liver and lung glutathione s-epoxide transferase: effects of phenobarbital and 3-methylcholanthrene administration.
Topics: Animals; Liver; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Phenobarbital; Species Specificity | 1976 |
Quantitative determination of cytochrome P-450 in rat liver homogenate.
Topics: Aniline Hydroxylase; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Hemoglobins; Indicators and Reagents; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1976 |
Effects of alteration of hepatic microsomal enzyme activity on liver blood flow in the rat.
Topics: Animals; Benzopyrenes; Cardiac Output; Enzyme Induction; Hemodynamics; Liver Circulation; Male; Methylcholanthrene; Microsomes, Liver; Microspheres; Phenobarbital; Proadifen; Rats; Zoxazolamine | 1976 |
[Mitochondrial respiration and the state of adenine nucleotide phosphorylation in rat liver following multiple administration of 3-methylcholanthrene and phenobarbital].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Coenzyme A; Ketone Bodies; Liver; Male; Methylcholanthrene; Mitochondria, Liver; Oxygen Consumption; Phenobarbital; Rats; Sulfhydryl Compounds | 1976 |
Effect of microsomal enzyme inducers on the biliary excretion of an exogenous load of bilirubin in newborn rats.
Topics: Age Factors; Animals; Animals, Newborn; Bile; Bilirubin; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1976 |
Inhibition of arylhydrocarbon hydroxylase induction in BALB/C mouse liver by delta9-tetrahydrocannabinol.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytidine; Depression, Chemical; Dronabinol; Drug Interactions; Enzyme Induction; Leucine; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Protein Biosynthesis; RNA | 1976 |
The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes.
Topics: Adenosine Monophosphate; Animals; Benzopyrenes; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Ethers, Cyclic; Flavonoids; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenols; Rats; Spectrophotometry | 1976 |
Multiplicity of liver microsomal cytochrome P-450: separation, purification and characterization.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cricetinae; Furosemide; Glutathione; Guinea Pigs; Humans; In Vitro Techniques; Iproniazid; Isoniazid; Liver Diseases; Methylcholanthrene; Mice; Phenobarbital; Rats | 1976 |
Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Stereoisomerism | 1976 |
Quantitative relationship between carcinogenicity and mutagenicity of polyaromatic hydrocarbons in Salmonella typhimurium mutants.
Topics: Air Pollutants; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Survival; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Induction; Genetic Code; Hydrocarbons; Liver; Liver Extracts; Male; Methylcholanthrene; Mutagens; Mutation; Phenobarbital; Rats; Salmonella typhimurium; Transcription, Genetic | 1975 |
Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.
Topics: Animals; Carcinogens; Dealkylation; Diethylamines; Diethylnitrosamine; Dimethylnitrosamine; Enzyme Induction; Histidine; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes, Liver; Mutagens; Nitrosamines; Phenobarbital; Proadifen; Salmonella typhimurium; Time Factors; Valerates | 1975 |
Metabolism of cigarette smoke condensates by human and rat homogenates to form mutagens detectable by Salmonella typhimurium TA1538.
Topics: Animals; Dose-Response Relationship, Drug; Humans; Liver; Methylcholanthrene; Mutagens; Phenobarbital; Polycyclic Compounds; Rats; Salmonella typhimurium; Smoking | 1975 |
Evidence for the activation of 3-methylcholanthrene as a carcinogen in vivo and asa mutagen in vitro by P1 -450 from inbred strains of mice.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Flavonoids; Genotype; Liver; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Microbial Sensitivity Tests; Mixed Function Oxygenases; Models, Biological; Molecular Biology; Mutagens; Naphthalenes; Oxygenases; Phenobarbital; Polycyclic Compounds; Salmonella typhimurium | 1975 |
Hydroperoxide dependent O-dealkylation reactions catalyzed by liver microsomal cytochrome P450.
Topics: Animals; Antimetabolites; Cytochrome P-450 Enzyme System; Dealkylation; Methylcholanthrene; Microsomes, Liver; Oxygen Consumption; Peroxides; Phenobarbital; Rabbits; Rats | 1975 |
Stimulation of immature male rat liver growth by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Bile Ducts; Body Weight; Cell Nucleus; DNA; Drug Synergism; Injections, Intraperitoneal; Liver; Male; Methylcholanthrene; Mitosis; Organ Size; Phenobarbital; Rats; Stimulation, Chemical | 1975 |
Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties.
Topics: Amines; Animals; Benzopyrenes; Benzphetamine; Chromatography, DEAE-Cellulose; Cyanides; Cytochrome P-450 Enzyme System; Hemeproteins; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Protein Conformation; Rats; Spectrophotometry | 1975 |
Spectral interactions of a series of chlorinated hydrocarbons with cytochrome P-450 of liver microsomes from variously-treated rats.
Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Hydrocarbons, Chlorinated; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1975 |
Deuterium isotope effects during formation of phenols by hepatic monoxygenases. Evidence for an alternative to arene oxide pathway.
Topics: Animals; Deuterium; Enzyme Induction; Isotope Labeling; Kinetics; Liver; Mass Spectrometry; Methylcholanthrene; Oxygenases; Phenobarbital; Phenols; Rats; Structure-Activity Relationship | 1975 |
Stimulation of choline incorporation into a membrane fraction of rat liver by barbitals in vitro.
Topics: Animals; Cell Fractionation; Choline; Chromatography, Gel; Cytosol; Hexobarbital; Liver; Membranes; Methylcholanthrene; Phenobarbital; Rats; Time Factors | 1975 |
Alteration by phenobarbital and 3-methyl-cholanthrene of functional and structural changes in rat liver due to carbon tetrachloride inhalation.
Topics: Amino Acids; Animals; Carbon Tetrachloride Poisoning; Endoplasmic Reticulum; Liver; Male; Methylcholanthrene; Microscopy, Electron; Phenobarbital; Polyribosomes; Rats; Ribosomes | 1975 |
Alkylation and carbamoylation intermediates from the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-1.
Topics: Acetates; Alkylation; Animals; Carbamates; Carbocysteine; Dicarboxylic Acids; Ethane; Ethylene Chlorohydrin; Halogens; Hydroxylation; Isomerism; Lomustine; Male; Methylcholanthrene; Microsomes; Nitrosourea Compounds; Phenobarbital; Rats; Sulfides | 1975 |
Benzo(a)pyrene-4,5-oxide hydratase: assay, properties, and induction.
Topics: Animals; Benzopyrenes; Chromatography, Thin Layer; Epoxide Hydrolases; Ethers, Cyclic; Hydro-Lyases; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pronase; Rats; Tritium | 1975 |
Highly purified cytochrome P-448 and P=450 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry | 1975 |
Aryl and aniline hydroxylases in rat nuclear membranes after pretreatment with pregnenolone 16alpha-carbonitrile, phenobarbital and methylcholanthrene.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cell Nucleus; Enzyme Induction; Liver; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1975 |
Transplacental control of epoxide hydratase and its relationship to the control of microsomal monooxygenase.
Topics: Animals; Benzopyrenes; Epoxide Hydrolases; Female; Hydro-Lyases; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Placenta; Pregnancy; Pregnenolone; Rats; Time Factors | 1975 |
Drug-induced alterations in hepatic fatty acid desaturase activity.
Topics: Animals; Appetite; Body Weight; Drinking; Fatty Acid Desaturases; Fatty Acids, Nonesterified; Fenfluramine; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1975 |
Effect of feeding and lighting on the regulation of aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity in the liver, small intestine, and lung of mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Circadian Rhythm; Eating; Enzyme Induction; Female; Injections; Injections, Intraperitoneal; Intestine, Small; Light; Liver; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Phenobarbital; Sex Factors; Species Specificity; Stomach | 1975 |
Species variations in the metabolism of acetophenone oxime by hepatic enzymes.
Topics: Acetophenones; Amines; Animals; Carbon Tetrachloride; Cricetinae; Cytosol; Depression, Chemical; Hydroxylamines; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases; Oximes; Phenobarbital; Rabbits; Rats; Species Specificity; Stimulation, Chemical | 1975 |
Metabolism of papaverine. III. Effect of phenobarbital, 3-methylcholanthrene and SKF 525-A pre-treated in vivo and in vitro.
Topics: Aminopyrine N-Demethylase; Animals; Bile; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases, O-Demethylating; Papaverine; Phenobarbital; Proadifen; Rats | 1975 |
Cytochrome P-450 in the activation and inactivation of carcinogens.
Topics: Animals; Aroclors; Biotransformation; Carcinogens; Choline Deficiency; Cytochrome P-450 Enzyme System; Deficiency Diseases; Dimethylnitrosamine; Humans; In Vitro Techniques; Inactivation, Metabolic; Kinetics; Liver; Male; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Microsomes, Liver; Mutagens; Oxidoreductases, N-Demethylating; Phenobarbital; Photochemistry | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
A rapid and sensitive liquid chromatographic assay for epoxide hydrase.
Topics: Animals; Chromatography, High Pressure Liquid; Epoxide Hydrolases; Glycols; Hydro-Lyases; Liver; Male; Methylcholanthrene; Microchemistry; Microsomes, Liver; Oxides; Phenobarbital; Rats | 1975 |
Effects of vinyl chloride exposures to rats pretreated with phenobarbital.
Topics: Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Environmental Exposure; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Rats; Vinyl Chloride; Vinyl Compounds | 1975 |
Drug induction and sex differences of renal glutathione S-transferases in the rat.
Topics: Animals; Benzopyrenes; Cytosol; Enzyme Induction; Female; Glutathione Transferase; Kidney; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Sex Factors; Transferases | 1975 |
Microsomal monooxygenation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Synthesis and identification of cis and trans monohydroxylated products.
Topics: Animals; Antineoplastic Agents; Carbon Monoxide; Hydroxylation; Lomustine; Male; Methylcholanthrene; Microsomes, Liver; Nitrosourea Compounds; Oxidation-Reduction; Phenobarbital; Rats; Stereoisomerism | 1975 |
Biliary excretion of drugs: role of ligandin in newborn immaturity and in the action of microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Biotransformation; Carrier Proteins; Enzyme Induction; Glutathione Transferase; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Protein Binding; Rats; Sulfobromophthalein; Time Factors | 1975 |
Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.
Topics: Animals; Carbon Tetrachloride; Carboxyhemoglobin; Hemoglobins; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rabbits | 1975 |
Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status. Distinction of two types by 7,8-benzoflavone.
Topics: Aging; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Diet; Enzyme Induction; Female; Flavonoids; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Sex Factors; Starvation | 1975 |
Opposite effects of phenobarbital pretreatment on aflatoxin B1-induced inhibition of transcription in rat and mouse liver.
Topics: Aflatoxins; Animals; Cell Nucleus; DNA-Directed RNA Polymerases; Liver; Male; Methylcholanthrene; Mice; Phenobarbital; Rats; RNA; Species Specificity; Transcription, Genetic | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 Enzyme System; Drug Interactions; Glutathione; Liver; Male; Maleates; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Necrosis; Phenobarbital; Rats | 1975 |
Characterization of microsomal electron transport components from control, phenobarbital and 3-methylcholanthrene treated mice: II. Resolution and quantitation of cytochromes P-450 and P1-450 and the so-called "factor X" in SDS-polyacrylamide gels of tota
Topics: Animals; Cytochrome P-450 Enzyme System; Electron Transport; Electrophoresis, Polyacrylamide Gel; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proteins | 1975 |
Histone modification in liver after administration of inducers of mixed function oxidase activity.
Topics: Acetates; Animals; Cell Nucleus; Dimethyl Sulfoxide; Histones; Liver; Male; Methylcholanthrene; Phenobarbital; Phosphoproteins; Rats | 1975 |
[Kinetic and spectral parameters of naphthalene hydroxylation by intact and induced enzyme systems of liver microsomes].
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Phenobarbital; Rats | 1975 |
Studies on the metabolism of dimethylnitrosamine in the rat. II. The effects of phenobarbitone and 20-methylcholanthrene on the in vitro and in vivo metabolism and acute toxicity of dimethylnitrosamine in young and mature rats.
Topics: Age Factors; Aminopyrine; Aniline Hydroxylase; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Ethylmorphine-N-Demethylase; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Rats; Sex Factors | 1975 |
[The effect of pretreatment with enzyme inducers on the acute toxicity of DDT (1, 1-bis-(p-chlorophenyl)-2,2,2-trichloroethane) in rats].
Topics: Animals; Brain; DDT; Drug Interactions; Enzyme Induction; Female; Liver; Methylcholanthrene; Norethandrolone; Phenobarbital; Rats | 1975 |
Effect of phenobarbital or 3-methylcholanthrene pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver.
Topics: Animals; Carbon Tetrachloride; In Vitro Techniques; Lipid Metabolism; Liver; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; Peroxides; Phenobarbital; Rats | 1975 |
Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Enzyme Induction; Flavonoids; In Vitro Techniques; Kidney; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Rabbits | 1975 |
Hepatic drug hydroxylation & lipid peroxidation during benzene treatment & the effect of phenobarbital & 3-methylcholanthrene pretreatment in adult rats.
Topics: Animals; Benzene; Female; Hydroxylation; Lipid Metabolism; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1975 |
Influence of phenobarbital and 3-methylcholanthrene pretreatment on kidney microsomal mixed function oxidase system during benzene and toluene intoxication in adult male rats.
Topics: Animals; Benzene; Depression, Chemical; Kidney; Male; Methylcholanthrene; Microsomes; Oxidoreductases; Phenobarbital; Rats; Toluene | 1975 |
[Interrelation of oxygen anion-radical generation and lipid peroxidation in liver microsomes].
Topics: Animals; Cytochrome Reductases; Lipid Metabolism; Methylcholanthrene; Microsomes, Liver; Peroxides; Phenobarbital; Rabbits; Rats | 1975 |
Studies on the substrate-induced spectral change of cytochrome P-450 in liver microsomes.
Topics: Alcohols; Alkanes; Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Conformation; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet | 1975 |
Differential control of rat microsomal "aryl hydrocarbon" monooxygenase and epoxide hydratase.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Epoxide Hydrolases; Female; Fetus; Hydro-Lyases; Liver; Methylcholanthrene; Microsomes, Liver; Mutagens; Nitriles; Phenobarbital; Pregnancy; Pregnenolone; Rats | 1976 |
Theophylline metabolism by the rat liver microsomal system.
Topics: Aldehyde Oxidoreductases; Animals; Cytosol; Female; Half-Life; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Proadifen; Rats; Theophylline; Time Factors; Xanthine Oxidase | 1976 |
Dimethylnitrosamine-demethylase: molecular size-dependence of repression by polynuclear hydrocarbons. Nonhydrocarbon repressors.
Topics: Animals; Dimethylnitrosamine; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Oxidoreductases, N-Demethylating; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Rats | 1976 |
The role of glutathione in chloroform-induced hepatotoxicity.
Topics: Acetone; Alkanes; Animals; Carbon Tetrachloride; Chloroform; Cysteamine; Cysteine; Dose-Response Relationship, Drug; Glutathione; Kidney; Lens, Crystalline; Liver; Male; Maleates; Methylcholanthrene; Phenobarbital; Propranolol; Rats | 1976 |
Effects of chronic administration of polybrominated biphenyls on parameters associated with hepatic drug metabolism.
Topics: Animals; Biphenyl Compounds; Diet; Enzyme Induction; Female; Growth; Liver; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1976 |
The influence of some foreign compounds on hepatic xenobiotic metabolism and the urinary excretion of D-glucuronic acid metabolites in the rat.
Topics: Animals; Butylated Hydroxytoluene; DDT; Female; Glucuronates; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1976 |
Purification of a substrate complex of cytochrome P-450 from liver microsomes of 3-methylcholanthrene-treated rabbits.
Topics: Animals; Binding Sites; Circular Dichroism; Cytochrome P-450 Enzyme System; Dithionite; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Protein Binding; Protein Conformation; Rabbits; Spectrophotometry; Spectrophotometry, Ultraviolet | 1976 |
Dimethylnitrosamine-demethylase: absence of increased enzyme catabolism and multiplicity of effector sites in repression. Hemoprotein involvement.
Topics: Animals; Carbon Monoxide; Caseins; Cytochrome P-450 Enzyme System; Dietary Proteins; Dimethylnitrosamine; Enzyme Repression; Hemeproteins; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1976 |
Environmental factors in drug metabolism.
Topics: Acetaminophen; Animals; Azo Compounds; Biotransformation; Cytochrome P-450 Enzyme System; Environment; Enzyme Induction; Intestinal Mucosa; Methylcholanthrene; Microsomes, Liver; Phenobarbital | 1976 |
Development of liver microsomal oxidations in the chick.
Topics: Aging; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chickens; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Sex Factors | 1976 |
Induction and characterization of cytochromes P450IA and -IIB in the newt, Pleurodeles waltl.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pleurodeles; Rats; Rats, Sprague-Dawley; Seasons; Sex Characteristics; Steroid 11-beta-Hydroxylase | 1992 |
Metabolism of FK 506 in differentially induced rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Tacrolimus | 1992 |
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Ketones; Liver; Male; Methylcholanthrene; Mirex; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Sprague-Dawley; Taurolithocholic Acid | 1992 |
Effect of flumecinol (Zixoryn) on the cytochrome P450 and cytochrome P448 dependent hepatic microsomal monooxygenase activities in male rats.
Topics: Administration, Oral; Animals; Benzhydryl Compounds; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Oxygenases; Phenobarbital; Rats; Rats, Wistar | 1992 |
[Effects of harman and norharman on aflatoxin B1 and aminopyrine metabolism by phenobarbital and 3-methylcholanthrene-induced rat liver microsomes].
Topics: Aflatoxin B1; Aminopyrine N-Demethylase; Animals; Carbolines; Harmine; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar | 1992 |
Effect of phenobarbital and 3-methylcholanthrene treatment on NADPH- and NADH-dependent production of reactive oxygen intermediates by rat liver nuclei.
Topics: Animals; Cell Nucleus; Enzyme Activation; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Differential oxidase activity of hepatic and pulmonary microsomal cytochrome P-450 isozymes after treatment with cytochrome P-450 inducers.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Lung; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Sprague-Dawley; Superoxides | 1992 |
Mechanism of antimutagenicity of wheat sprout extracts.
Topics: Animals; Antimutagenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Chlorophyll; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Oxidoreductases; Phenobarbital; Plant Extracts; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Triticum | 1992 |
Comparative effects of chloroflavone congeners as inducers of hepatic microsomal monooxygenases in rats.
Topics: Aminopyrine N-Demethylase; Animals; Coumarins; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism | 1992 |
The effect of age on inducibility of various types of rat liver cytochrome P-450.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred BN; RNA, Messenger; Safrole | 1992 |
Effects of arsenite on hepatic mixed-function oxidase activity in rats.
Topics: Animals; Arsenic; Arsenites; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar; Safrole | 1992 |
Differential effects of cytochrome P-450 induction on ligand binding to sigma receptors.
Topics: Animals; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Guanidine; Guanidines; In Vitro Techniques; Liver; Male; Methylcholanthrene; Pentazocine; Phenobarbital; Rats; Rats, Sprague-Dawley; Receptors, sigma; Subcellular Fractions; Tritium | 1992 |
Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).
Topics: Animals; Benzo(a)pyrene; Cells, Cultured; Chrysenes; Cricetinae; Enzyme Induction; Glucuronates; Glucuronosyltransferase; In Vitro Techniques; Liver; Methylcholanthrene; Phenobarbital; Phenols; Rats | 1992 |
Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenotype; Pyrazoles; Rats; Rats, Inbred Strains; Selection, Genetic; Species Specificity | 1992 |
Hepatic mixed function oxidase system and effect of phenobarbital, 3-methylcholanthrene and 1, 1, 1-trichloro-2, 2-bis(p-chlorophenyl)ethane in developing chickens.
Topics: Animals; Chickens; DDT; Enzyme Induction; Hydrogen Peroxide; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Stimulation, Chemical | 1992 |
Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biphenyl Compounds; Dogs; Enzyme Induction; Glucuronosyltransferase; Guinea Pigs; Intestinal Mucosa; Kidney; Lung; Macaca mulatta; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Naphthols; Phenobarbital; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Tissue Distribution | 1992 |
Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract.
Topics: Animals; Base Sequence; Benzoflavones; beta-Naphthoflavone; Blotting, Northern; Cell Nucleus; Cytochrome P-450 Enzyme System; DNA Probes; Enzyme Induction; Esophagus; Gastric Mucosa; Gene Expression; Gene Expression Regulation, Enzymologic; Intestinal Mucosa; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Mucous Membrane; Oligodeoxyribonucleotides; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Reference Values; RNA, Messenger; Transcription, Genetic | 1992 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis, Polyacrylamide Gel; Kinetics; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1992 |
UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyroidectomy | 1992 |
Variations in immunoreactivity for phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450, and NADPH-cytochrome P-450 reductase in rat liver over twenty-four hours.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunohistochemistry; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1992 |
Male rat hepatic UDP-glucuronosyltransferase activity toward thyroxine. Activation and induction properties--relation with thyroxine plasma disappearance rate.
Topics: Animals; Detergents; Enzyme Activation; Enzyme Induction; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Thyrotropin; Thyroxine; Triiodothyronine | 1992 |
Optimal detergent activation of rat liver microsomal UDP-glucuronosyl transferases toward morphine and 1-naphthol: contribution to induction and latency studies.
Topics: Animals; Detergents; Enzyme Activation; Enzyme Induction; Glucuronosyltransferase; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Naphthols; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Bromobenzene-glutathione excretion into bile reflects toxic activation of bromobenzene in rats.
Topics: Animals; Bile; Biotransformation; Bromobenzenes; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glutathione; Injections, Intraperitoneal; Liver; Male; Methylcholanthrene; Phenobarbital; Polysorbates; Rats | 1992 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; Methylcholanthrene; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1992 |
1-C-glucuronidation of N-nitrosodiethylamine and N-nitrosomethyl-n-pentylamine in vivo and in primary hepatocytes from rats pretreated with inducers.
Topics: Animals; Aroclors; Chromatography, High Pressure Liquid; Diethylnitrosamine; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Organ Specificity; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Urinary Bladder | 1992 |
A simplified approach for evaluation of hepatic drug-oxidizing activity with a simultaneous determination of caffeine and trimethadione and their demethylated metabolites in rats with a selective cytochrome P-450 inducer.
Topics: Animals; Caffeine; Cytochrome P-450 Enzyme System; Humans; Liver; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Trimethadione | 1992 |
Microsomal lauric acid hydroxylase activities after treatment of rats with three classical cytochrome P450 inducers and peroxisome proliferating compounds.
Topics: Adipates; Animals; Aroclors; Body Weight; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Enzyme Induction; Male; Methylcholanthrene; Microbodies; Microsomes, Liver; Mixed Function Oxygenases; Nafenopin; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1992 |
Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Replication; Enzyme Induction; Female; Kidney; Liver; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Thymidine | 1992 |
Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2.
Topics: Carcinoma, Hepatocellular; Enzyme Induction; Humans; Liver Neoplasms; Methylcholanthrene; Mutagens; Phenobarbital; Pyrenes; Subcellular Fractions; Tumor Cells, Cultured | 1991 |
Effect of microsomal enzyme inducing agents on hepatic biotransformation in cotton rats (Sigmodon hispidus): comparison to that in Sprague-Dawley rats.
Topics: Animals; Arylsulfotransferase; Biotransformation; Cytochrome P-450 Enzyme System; Dinitrochlorobenzene; Enzyme Induction; Ethacrynic Acid; Female; Glucuronosyltransferase; Glutathione Transferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sulfobromophthalein; Sulfotransferases | 1991 |
Expression and regulation of drug metabolizing enzymes in an immortalized rat hepatocyte cell line.
Topics: Animals; Cell Differentiation; Cell Line; Cell Transformation, Viral; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; gamma-Glutamyltransferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Phenotype; Rats; Rats, Inbred Strains; Simian virus 40; Tyrosine Transaminase | 1991 |
Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction.
Topics: Aging; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cytochrome P-450 Enzyme System; DNA; Gene Expression Regulation, Enzymologic; Genes; Isoenzymes; Liver; Methylcholanthrene; Molecular Sequence Data; Oligonucleotide Probes; Organ Specificity; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; Reference Values; RNA; RNA, Messenger | 1990 |
Interactions of FK 506 and cyclosporine metabolism.
Topics: Animals; Cyclosporine; Drug Interactions; Humans; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Tacrolimus | 1991 |
Effect of phenobarbital and 3-methylcholanthrene on the early oxidative stress component induced by lindane in rat liver.
Topics: Animals; Bile; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Glutathione; Hexachlorocyclohexane; Lipid Peroxides; Liver; Male; Methylcholanthrene; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Stress, Physiological | 1991 |
A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver.
Topics: Animals; Antibodies, Monoclonal; Benzene; Chloral Hydrate; Cytochrome P-450 Enzyme System; Ethanol; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Toluene; Trichloroethylene | 1992 |
The effect of dose and enzyme inducers on the metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Feces; Imidazoles; Male; Methylcholanthrene; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred F344; Tissue Distribution | 1991 |
Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Blotting, Western; Cells, Cultured; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Xenobiotics | 1991 |
Relationship between oxidative stress and hepatic phosphoglucomutase activity in rats.
Topics: Administration, Oral; Animals; Calcium Chloride; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Linoleic Acids; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methylcholanthrene; Methylene Blue; Oxygen; Paraquat; Phenobarbital; Phosphoglucomutase; Rats; Rats, Inbred Strains; Thiobarbiturates; Thiopental; Vitamin E | 1991 |
In micronodular cirrhosis, hepatocytes retain a normal C-25 hydroxylation capacity toward vitamin D3: a study using the rat carbon tetrachloride-induced cirrhotic model.
Topics: Animals; Calcifediol; Carbon Tetrachloride; Cholecalciferol; Cytochrome P-450 Enzyme System; Hydroxylation; Liver; Liver Cirrhosis, Experimental; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Porphyrin synthesis by human hepatocytes and HepG2 cells--effects of enzyme inducers and delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Enzyme Induction; Hexachlorobenzene; Humans; Hydroxymethylbilane Synthase; Liver; Liver Neoplasms; Methylcholanthrene; Phenobarbital; Porphyrins; Tumor Cells, Cultured; Uroporphyrinogen Decarboxylase | 1991 |
Effect of avarol, avarone and nine of their natural and synthetic derivatives on microsomal drug-metabolizing enzymes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antineoplastic Agents; Cyclohexenes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sesquiterpenes | 1991 |
Differential effects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Interferon Type I; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred CBA; Microsomes, Liver; Oxidoreductases; Oxygenases; Phenobarbital; Recombinant Proteins | 1991 |
Comparison of the rat liver microsomal metabolism of the enantiomers of warfarin and 4'-nitrowarfarin (acenocoumarol).
Topics: Acenocoumarol; Animals; Chromatography, High Pressure Liquid; Cimetidine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism; Warfarin | 1991 |
Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics and the pharmacodynamics of bumetanide in rats.
Topics: Animals; Blood Proteins; Bumetanide; Chlorides; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Gastric Mucosa; Kidney; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Potassium; Protein Binding; Rats; Rats, Inbred Strains; Sodium | 1991 |
Site-selective oxidation of strychnine by phenobarbital inducible cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Dogs; Guinea Pigs; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Mice; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Strychnine | 1991 |
Effect of chemicals on glutathione peroxidase of chick liver.
Topics: Animals; Benzene Derivatives; Butylated Hydroxyanisole; Chickens; Chromatography, Gel; Clofibrate; Glutathione Peroxidase; Hydrogen Peroxide; Liver; Male; Methylcholanthrene; Phenobarbital; Stilbenes | 1991 |
Novel stereoselectivity of rat liver cytochrome(s) P450 toward enantiomers of the trans-1,2-dihydrodiol of triphenylene.
Topics: Animals; Chrysenes; Cytochrome P-450 Enzyme System; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Stereoisomerism; Substrate Specificity | 1991 |
Induction of alkoxyresorufin O-dealkylases and UDP-glucuronosyl transferase by phenobarbital and 3-methylcholanthrene in primary cultures of porcine ciliary epithelial cells.
Topics: Animals; Cells, Cultured; Ciliary Body; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Inactivation, Metabolic; Methylcholanthrene; Oxidoreductases; Phenobarbital; Pigment Epithelium of Eye; Swine | 1991 |
On-line measurements of 13C enrichments in rat breath. Non-invasive method for in vivo study of drug enzymatic induction.
Topics: Animals; Breath Tests; Caffeine; Carbon Dioxide; Carbon Isotopes; Cytochrome P-450 Enzyme System; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats | 1991 |
Glucuronidation and sulfation in subcellular fractions and in the isolated perfused rabbit lung: influence of ethanol.
Topics: Animals; Catechols; Chromatography, Thin Layer; Ethanol; Glucuronates; Glucuronosyltransferase; In Vitro Techniques; Liver; Lung; Male; Methylcholanthrene; Naphthols; Phenobarbital; Phenolphthalein; Phenolphthaleins; Rabbits; Subcellular Fractions; Sulfates; Sulfotransferases; Umbelliferones | 1991 |
Drug-induction decreases the mobility of cytochrome P-450 in rat liver microsomes: protein rotation study.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorescence Polarization; Intracellular Membranes; Kinetics; Male; Membrane Fluidity; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Photolysis; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Reference Values | 1991 |
[Induction of cytochrome P-450 by triterpensaponins in Vietnamese ginseng].
Topics: Aminopyrine; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Saponins; Triterpenes | 1991 |
Immunocytochemical study of phenobarbital- and 3-methylcholanthrene-inducible cytochrome P450 isozymes in primary cultures of porcine ciliary epithelium.
Topics: Animals; Cells, Cultured; Ciliary Body; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Epithelium; Immunoenzyme Techniques; Immunohistochemistry; Isoenzymes; Methylcholanthrene; Microsomes; Oxidoreductases; Phenobarbital; Pigment Epithelium of Eye; Swine | 1991 |
Alteration of aflatoxin B1 metabolic profiles and reduction of aflatoxin B1 mutagenicity by hepatic microsomes of rats fed butylated hydroxyanisole.
Topics: Aflatoxin B1; Animals; Butylated Hydroxyanisole; Chromatography, High Pressure Liquid; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1991 |
Renal and hepatic microsomal enzymes responsible for bioactivation of 3-methoxy-4-aminoazobenzene in the rodent.
Topics: Animals; Biotransformation; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Hydroxylation; Kidney; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Mutagenicity Tests; p-Aminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344 | 1991 |
Effects of phenobarbital and 3-methylcholanthrene pretreatment on the pharmacokinetics and pharmacodynamics of furosemide in rats.
Topics: Animals; Blood Proteins; Chlorides; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Furosemide; Gastric Mucosa; Kidney; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Potassium; Protein Binding; Rats; Rats, Inbred Strains; Sodium; Tissue Distribution | 1991 |
Characterization of covalent binding of [14C]-2-chloro-4-acetotoluidide to microsomes of starling liver and kidney.
Topics: Animals; Benzoflavones; Birds; Cysteine; Cytochrome P-450 Enzyme Inhibitors; Glutathione; In Vitro Techniques; Kidney; Kinetics; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Protein Binding; Sulfhydryl Compounds; Toluidines | 1991 |
Metabolism of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-pretreated rats: stimulation and stereochemical effects by induction of cytochromes P450IIE1, P450IIB and P450IA.
Topics: Acetone; Administration, Inhalation; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Enzyme Induction; Kidney; Lung; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism; Styrenes | 1991 |
In vitro effects of an imidazole antifungal, prochloraz, on spectral and catalytic properties of microsomal cytochromes P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Dexamethasone; Fungicides, Industrial; Imidazoles; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal T4 metabolism and thyroid gland function in rats.
Topics: Amiodarone; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochromes b5; Glucuronosyltransferase; Kidney; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxygenases; Phenobarbital; Phenytoin; Propylthiouracil; Rats; Rats, Inbred Strains; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1991 |
Distribution and induction of alkoxyresorufin O-dealkylases and gamma-glutamyl transpeptidase in porcine ciliary epithelium.
Topics: Animals; Cells, Cultured; Ciliary Body; Cycloheximide; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Epithelium; gamma-Glutamyltransferase; Methylcholanthrene; Microsomes; Oxidoreductases; Phenobarbital; Swine | 1990 |
Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver.
Topics: Animals; Antibodies, Monoclonal; Benzyl Alcohol; Benzyl Alcohols; Cresols; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanol; Isoenzymes; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Toluene | 1991 |
Positional specificity for methyl-n-amylnitrosamine hydroxylation by cytochrome P-450 isozymes determined with monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Aroclors; Carcinogens; Cytochrome P-450 Enzyme System; Hydroxylation; Isoenzymes; Isoniazid; Liver; Male; Methylcholanthrene; Microsomes; Nitrosamines; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Sex Factors; Substrate Specificity | 1991 |
The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.
Topics: Animals; Cyclic N-Oxides; Enzyme Induction; Kidney; Liver; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen Oxides; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Spin Labels | 1991 |
Unimpaired induction of drug-metabolizing enzymes in hepatocytes isolated from rats with micronodular cirrhosis.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Kinetics; Liver; Liver Cirrhosis, Experimental; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Xenobiotics | 1991 |
Comparison of cytochrome P-450 species which catalyze the hydroxylations of the aromatic ring of estradiol and estradiol 17-sulfate.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Estradiol; Estrogens, Catechol; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1991 |
Role of mixed-function oxidases and non-protein sulfhydryl content in [14C]-2-chloro-4-acetotoluidide binding to liver and kidney in starlings.
Topics: Animals; Birds; Carbon Radioisotopes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Kidney; Liver; Male; Maleates; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Pyridines; Sulfhydryl Compounds; Toluidines | 1990 |
Influence of hormones and drugs on glutathione-S-transferase levels in primary culture of adult rat hepatocytes.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Glutathione Transferase; Hormones; Liver; Methylcholanthrene; Phenobarbital; Rats; Substrate Specificity | 1990 |
Neonatal diethylstilbestrol treatment alters aflatoxin B1-DNA adduct concentrations in adult rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Animals, Newborn; Body Weight; Carcinogens; Chromatography, High Pressure Liquid; Diethylstilbestrol; DNA; Female; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Pyrimidines; Rats; Rats, Inbred Strains; Testis; Time Factors | 1990 |
Kinetic characteristics of UDP-glucuronosyltransferases towards a dithiol metabolite of malotilate in hepatic microsomes of rats and rabbits.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Hydrogen-Ion Concentration; Kinetics; Male; Malonates; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Toluene | 1990 |
One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase.
Topics: Aerobiosis; Alkylating Agents; Alkylation; Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Electron Transport; Glucose Oxidase; Hydrogen Peroxide; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitomycin; Mitomycins; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Responses of cytochrome P-450 isozymes of rat lung to in vivo exposure to ozone.
Topics: Animals; Cytochrome P-450 Enzyme System; Isoenzymes; Lung; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Ozone; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Species difference in codeine uridine diphosphate-glucuronyltransferase activity of liver microsomes.
Topics: Animals; Biphenyl Compounds; Codeine; Enzyme Induction; Glucuronosyltransferase; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Nitrophenols; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Substrate Specificity | 1990 |
Effect of UDP-glucuronyltransferase induction on zearalenone metabolism.
Topics: Animals; Biphenyl Compounds; Enzyme Induction; Female; Glucuronosyltransferase; Inactivation, Metabolic; Isoenzymes; Liver; Methylcholanthrene; Naphthols; Phenobarbital; Rats; Rats, Inbred Strains; Resorcinols; Zearalenone | 1990 |
Effects of various inducers on diethylstilbestrol metabolism, drug-metabolizing enzyme activities and the aromatic hydrocarbon (Ah) receptor in male Syrian golden hamster liver.
Topics: Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme System; Cytochromes b5; Diethylstilbestrol; Drug Interactions; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1990 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured | 1990 |
Expression of cytochrome P-450 enzymes in cultured human hepatocytes.
Topics: Adult; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Immunoenzyme Techniques; Infant, Newborn; Isoenzymes; Liver; Methylcholanthrene; Phenobarbital; Rifampin; RNA, Messenger | 1990 |
Effects of inducers and inhibitors of mixed-function oxidases on the biliary excretion of pentacaine metabolites.
Topics: Animals; Bile; Carbamates; Enzyme Induction; Injections, Intravenous; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Portal Vein; Pyridines; Rats; Rats, Inbred Strains | 1990 |
Ethanol-inducible cytochrome P-450: assessment of substrates' specific chemical probes in rat liver microsomes.
Topics: Acetone; Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1990 |
[Diazepam metabolism by multiple forms of cytochrome P-450 in rat liver microsomes].
Topics: Animals; Biotransformation; Cytochromes; Dealkylation; Dexamethasone; Diazepam; Enzyme Induction; In Vitro Techniques; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Metabolism of 2S-hydroxy-3-methylcholanthrene by rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1990 |
Inhibition of arylhydrocarbon hydroxylase and cytochrome P-450 by 20-methylcholanthrene and phenobarbital in guinea pig on excessive doses of ascorbic acid.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochromes b5; Guinea Pigs; Liver; Lung; Male; Methylcholanthrene; Phenobarbital | 1990 |
Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Immunoblotting; Liver; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Molecular Sequence Data; Nucleic Acid Hybridization; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; Restriction Mapping; Sequence Homology, Nucleic Acid | 1990 |
Modification of 7,8-benzoflavone metabolism in hamster liver and kidney microsomes by hepatic tumor inducing treatments.
Topics: Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Diethylstilbestrol; Flavonoids; Kidney; Liver Neoplasms; Male; Mesocricetus; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Reference Values | 1990 |
Biotransformation of lovastatin--III. Effect of cimetidine and famotidine on in vitro metabolism of lovastatin by rat and human liver microsomes.
Topics: Animals; Biotransformation; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Female; Humans; Lovastatin; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Methylcholanthrene but not phenobarbital enhances caffeine and theophylline metabolism in cultured adult human hepatocytes.
Topics: Adult; Biotransformation; Caffeine; Cells, Cultured; Humans; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Theophylline | 1990 |
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states.
Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline | 1990 |
Oxidation of glycerol to formaldehyde by rat liver microsomes. Effects of cytochrome P-450 inducing agents.
Topics: Acetone; Aldehyde Oxidoreductases; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fomepizole; Formaldehyde; Glycerol; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1990 |
The effects of inducers of the endoplasmic reticulum, peroxisomes and mitochondria on the amounts and synthesis of ubiquinone in rat liver subcellular membranes.
Topics: Animals; Cholesterol, Dietary; Cholestyramine Resin; Chromatography, High Pressure Liquid; Clofibrate; Diethylhexyl Phthalate; Diethylnitrosamine; Dolichols; Endoplasmic Reticulum; Intracellular Membranes; Liver; Methylcholanthrene; Mevalonic Acid; Microbodies; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Ubiquinone | 1990 |
Three forms of trichloroethylene-metabolizing enzymes in rat liver induced by ethanol, phenobarbital, and 3-methylcholanthrene.
Topics: Animals; Chloral Hydrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Hydroxylation; Isoenzymes; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Rats, Inbred Strains; Trichloroethylene | 1990 |
The steroid antagonist RU38486 is metabolized by the liver microsomal P450 mono-oxygenases.
Topics: Aging; Animals; Antibodies; Biotransformation; Cytochrome P-450 Enzyme System; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mifepristone; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Liver; Male; Methylcholanthrene; Middle Aged; Oxygenases; Phenobarbital; Xenobiotics | 1990 |
Differential induction of 3-ethyl-2,6-dimethyl-4H-pyrido (1,2-alpha)pyrimidin-4-one metabolism by phenobarbital and 3-methylcholanthrene in microsomes and isolated perfused rat liver.
Topics: Animals; Centrifugation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pyrimidinones; Rats; Rats, Inbred Strains; Xenobiotics | 1990 |
Lack of induction of rat liver mixed-function oxidases after chronic administration of high brotizolam doses to rats.
Topics: Animals; Azepines; Chromatography, High Pressure Liquid; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Phenobarbital; Rats | 1990 |
1-Hydroxy- and 2-hydroxy-3-methylcholanthrene: regioselective and stereoselective formations in the metabolism of 3-methylcholanthrene and enantioselective disposition in rat liver microsomes.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Circular Dichroism; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Organ Specificity; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
The metabolism of the carcinogen dibenz[a,j]acridine in isolated rat hepatocytes and in vivo in rats.
Topics: Acridines; Animals; Arylsulfatases; Carcinogens; DNA; Feces; Glucuronidase; Hydrolysis; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1990 |
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone | 1990 |
Cytochrome P-450 dependent monooxygenases in neuronal and glial cells: inducibility and specificity.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Brain; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Neuroglia; Neurons; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1990 |
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione | 1990 |
Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred F344 | 1990 |
Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats.
Topics: Acetone; Animals; Body Weight; Cytochrome P-450 Enzyme System; Glutathione; Lung; Lung Diseases; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Styrene; Styrenes; Sulfides | 1990 |
Monoclonal antibody-directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism in rat liver microsomes.
Topics: Animals; Antibodies, Monoclonal; Benzene; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanol; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxazines; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1990 |
Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Furylfuramide; Humans; Inactivation, Metabolic; Kinetics; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Neoplasms; Nitrofurans; Phenobarbital; Rats; Reference Values; Salmonella typhimurium; Spectrophotometry | 1990 |
Transcriptional regulation of rat liver glutathione S-transferase genes by phenobarbital and 3-methylcholanthrene.
Topics: Amanitins; Animals; Glutathione Transferase; Liver; Male; Methylcholanthrene; Nucleic Acid Hybridization; Phenobarbital; Rats; Rats, Inbred Strains; RNA; RNA Polymerase II; RNA, Messenger; Time Factors; Transcription, Genetic | 1985 |
Monoclonal antibodies against a high spin form of rat cytochrome P-448.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Epitopes; Hybridomas; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1985 |
Influence of chlordecone and mirex exposure on benzo[a]pyrene metabolism of rat-liver microsomes.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Biotransformation; Chlordecone; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Insecticides; Liver; Methylcholanthrene; Microsomes, Liver; Mirex; Pesticide Residues; Phenobarbital; Rats; Subcellular Fractions | 1987 |
Studies on the metabolism of aminopyrine, antipyrine and theophylline using monoclonal antibodies to cytochrome P-450 isozymes purified from rat liver.
Topics: Aminopyrine; Animals; Antibodies, Monoclonal; Antibody Specificity; Antipyrine; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Activation; Epitopes; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Theophylline | 1987 |
Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Chlordecone; Cytochrome P-450 Enzyme System; Gerbillinae; Insecticides; Male; Methylcholanthrene; Microsomes, Liver; Mirex; Phenobarbital | 1987 |
Phenolsulphonphthalein conjugation and biliary excretion in the rat: influence of phenobarbital and 3-methylcholanthrene.
Topics: Animals; Bile; Biotransformation; Glucuronates; Glucuronosyltransferase; Male; Methylcholanthrene; Phenobarbital; Phenolphthaleins; Phenolsulfonphthalein; Rats; Rats, Inbred Strains | 1988 |
Distribution and induction sites of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in murine liver: immunohistochemical localization with monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Activation; Epitopes; Immunoenzyme Techniques; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital | 1988 |
Induction of cytochrome P-450 isozymes by mirex and chlordecone.
Topics: Animals; Chlordecone; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunoblotting; In Vitro Techniques; Insecticides; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mirex; Mixed Function Oxygenases; Organ Size; Phenobarbital | 1989 |
Using the scoparone O-demethylase assay for categorizing types of hepatic microsomal monooxygenase inducers.
Topics: Animals; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, O-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1989 |
Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases.
Topics: Animals; Binding Sites; Enzyme Activation; Enzyme Induction; Glutathione Transferase; Intestines; Isoenzymes; Kidney; Liver; Male; Methylcholanthrene; Nitrate Reductase; Nitrate Reductases; Nitroglycerin; Phenobarbital; Rats; Rats, Inbred Strains; Subcellular Fractions; Tissue Distribution | 1989 |
Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture.
Topics: Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Hexachlorobenzene; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Structure-Activity Relationship | 1989 |
The phenobarbital-type induction of rat liver microsomal monooxygenases by perfluorodecalin.
Topics: Androstenedione; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Fluorocarbons; Immunodiffusion; Immunoelectrophoresis; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Comparison of the formation of benzo[a]pyrene diolepoxide-DNA adducts in vitro by rat and human microsomes: evidence for the involvement of P-450IA1 and P-450IA2.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; DNA Adducts; Enzyme Induction; Female; Humans; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Species Specificity; Spectrometry, Fluorescence | 1989 |
Localization of the active center of nitroxide radical reduction in rat liver microsomes: its relation to cytochrome P-450 and membrane fluidity.
Topics: Animals; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; In Vitro Techniques; Male; Membrane Fluidity; Methylcholanthrene; Microsomes, Liver; Nitrogen Oxides; Oxidation-Reduction; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1989 |
Effects of phenobarbital and 3-methylcholanthrene on the hepatic cytochrome P-450 metabolism of various alkoxyresorufin ethers in the cotton rat (Sigmodon hispidus).
Topics: Animals; Arvicolinae; Cytochrome P-450 Enzyme System; Dealkylation; Ethers; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxazines; Phenobarbital; Sex Factors | 1989 |
Inducibility of liver cytosolic aldehyde dehydrogenase activity in various animal species.
Topics: Aldehyde Dehydrogenase; Animals; Chickens; Cytosol; Enzyme Induction; Guinea Pigs; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Rana ridibunda; Rats; Rats, Inbred Strains; Species Specificity; Triturus; Trout | 1989 |
Monoclonal antibodies to cytochrome P-450 immunopurify a 45-kDa protein from a human lymphoblastoid cell line.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Cell Line; Cytochrome P-450 Enzyme System; Enzyme Induction; Epitopes; Humans; Immunologic Techniques; Liver; Lymphocytes; Methylcholanthrene; Phenobarbital; Rats | 1985 |
Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase.
Topics: Animals; Butylated Hydroxyanisole; Cytosol; Diterpenes; Enzyme Induction; Glutaredoxins; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Isoenzymes; Lactoylglutathione Lyase; Liver; Methylcholanthrene; Mice; Organ Size; Oxidoreductases; Phenobarbital; Protein Disulfide Reductase (Glutathione); Stilbenes | 1989 |
In vitro and in vivo modulation of the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in hamster lung tissues.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Cricetinae; Kinetics; Lung; Male; Mesocricetus; Methylcholanthrene; Nitrosamines; Organ Culture Techniques; Oxidation-Reduction; Phenobarbital; Proadifen; Protein Binding; Proteins; Reference Values | 1989 |
Effect in the rat of the interaction of dichloromaleic acid and carbon tetrachloride on renal and hepatic function.
Topics: Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Drinking; Female; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Maleates; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Water Pollutants; Water Pollutants, Chemical | 1989 |
[Changes in the metabolism of a pyrido(1,2 a)pyrimidine derivative, CH-150, under the effects of 3-methylcholanthrene and phenobarbital in microsome fractions in rats, studied by liver perfusion method].
Topics: Animals; Biotransformation; Carbon Radioisotopes; Liver; Methylcholanthrene; Microsomes, Liver; Perfusion; Phenobarbital; Pyrimidines; Pyrimidinones; Rats; Rats, Inbred Strains | 1989 |
Induction of hepatic cytochrome P-450 activity in wild cotton rats (Sigmodon hispidus) by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Arvicolinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Methylcholanthrene; Organ Size; Phenobarbital; Pregnancy | 1989 |
Effects of cytochrome P450-inducing agents on the monooxygenation of testosterone in long-term cultures of hepatocytes from male and female rats.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Glucagon; Hydroxylation; Insulin; Isoniazid; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Species Specificity; Steroid 16-alpha-Hydroxylase; Testosterone | 1989 |
Pulegone mediated hepatotoxicity: evidence for covalent binding of R(+)-[14C]pulegone to microsomal proteins in vitro.
Topics: Animals; Carbon Radioisotopes; Cyclohexane Monoterpenes; Kinetics; Liver; Menthol; Methylcholanthrene; Microsomes, Liver; Monoterpenes; Phenobarbital; Protein Binding; Proteins; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Antioxidants; Bile; Biotransformation; Cricetinae; Cysteamine; Liver; Male; Mesocricetus; Methylcholanthrene; Phenobarbital; Prostaglandin Antagonists | 1989 |
Suppression in the expression of a male-specific cytochrome P450, P450-male: difference in the effect of chemical inducers on P450-male mRNA and protein in rat livers.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Gene Expression Regulation; Hypophysectomy; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Sex Factors; Transcription, Genetic | 1989 |
Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Influence of sex and enzyme induction and inhibition.
Topics: Acetates; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Glucuronates; Hydroxides; Isoenzymes; Kinetics; Liver; Male; Methylcholanthrene; Metronidazole; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Sulfates | 1989 |
Fluorometric assay of hepatic microsomal monooxygenases by use of 7-methoxyquinoline.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Quinolines; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1989 |
Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes.
Topics: Animals; Aroclors; Biotransformation; Bronchi; Chromatography, High Pressure Liquid; Chrysenes; DNA; Humans; Liver; Male; Methylcholanthrene; Oxidation-Reduction; Phenanthrenes; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
N-oxygenation of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent: the role of flavin-containing monooxygenase.
Topics: Animals; Anti-Arrhythmia Agents; Flavins; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Male; Methimazole; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Oxygen; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains | 1989 |
Characterization of 3-methylcholanthrene effects on the rat glucocorticoid receptor in vivo.
Topics: Animals; Carcinogens; Cytosol; Dexamethasone; Female; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Receptors, Androgen; Receptors, Glucocorticoid | 1989 |
Distribution and induction of cytochrome P-450 and two cytochrome P-450-dependent monooxygenase activities in rat liver parenchymal cell subpopulations separated by centrifugal elutriation.
Topics: Alanine Transaminase; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyruvate Kinase; Rats; Rats, Inbred Strains | 1989 |
[Identification of molecular forms of cytochrome P-450 isolated from liver microsomes of rats induced with phenobarbital and 3-methylcholanthrene].
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Hydroxylation; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Steroid 16-alpha-Hydroxylase | 1989 |
Tissue distribution of inducible aldehyde dehydrogenase activity in the rat after treatment with phenobarbital or methylcholanthrene.
Topics: Aldehyde Dehydrogenase; Animals; Brain; Cytosol; Enzyme Activation; Enzyme Induction; Intestines; Kidney; Liver; Lung; Male; Methylcholanthrene; Myocardium; Phenobarbital; Rats; Rats, Inbred Strains; Spleen; Testis; Urinary Bladder | 1989 |
7-ethenyloxycoumarin as a new substrate for fluorophotometric assay of hepatic microsomal epoxidizing activities.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spectrophotometry; Umbelliferones | 1989 |
Role of carboxylesterase in protection against soman toxicity.
Topics: Animals; Blood Proteins; Carboxylic Ester Hydrolases; Lethal Dose 50; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Soman | 1989 |
Changes in the inducibility of a hepatic aldehyde dehydrogenase by various effectors.
Topics: Aldehyde Dehydrogenase; Animals; Cyanamide; Disulfiram; Enzyme Induction; Isoenzymes; Male; Methylcholanthrene; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1989 |
Gene structure and regulation of cytochrome P-450.
Topics: Animals; Base Sequence; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Gene Expression Regulation; Methylcholanthrene; Molecular Sequence Data; Phenobarbital; Rats | 1989 |
Selective induction of the coumarin hydroxylase by N-containing heteroaromatic compounds.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2A6; Enzyme Induction; Ethylmorphine; Heterocyclic Compounds; Imidazoles; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Oxazines; Phenobarbital; Pyrazoles; Pyridines; Structure-Activity Relationship | 1989 |
Induction of drug-metabolizing enzymes in Gunn rat liver. Effect of polycyclic aromatic hydrocarbons on cytochrome P-450 regulation.
Topics: Animals; Carrier Proteins; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats; Rats, Gunn; Rats, Inbred Strains | 1989 |
Induction of ornithine decarboxylase and S-adenosylmethionine decarboxylase by sulfobromophthalein in rats.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Kinetics; Liver; Male; Methylcholanthrene; Ornithine Decarboxylase; Phenobarbital; Polyamines; Rats; Rats, Inbred Strains; Sulfobromophthalein | 1989 |
Selective expression and induction of cytochrome P450PB and P450MC during the development of hereditary hepatitis and hepatoma of LEC rats.
Topics: Age Factors; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Neoplastic; Hepatitis, Animal; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Effect of endotoxin to differentially affect cytochrome P-450 monooxygenase activities of untreated rats and animals induced with phenobarbital or 3-methylcholanthrene.
Topics: Animals; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Induction; Heme Oxygenase (Decyclizing); Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
[The effect of separate and consecutive administration of cytochrome P-450 inducers to rats on the localization of various isoforms of the enzyme in liver lobe cells].
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunohistochemistry; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Metabolism of antipyrine and m-xylene in rats after prolonged pretreatment with xylene alone or xylene with ethanol, phenobarbital or 3-methylcholanthrene.
Topics: Administration, Inhalation; Administration, Oral; Animals; Antipyrine; Drug Interactions; Ethanol; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Xylenes | 1989 |
Protection of rat from oxygen toxicity by inducers of cytochrome P-450 system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Hydrogen Peroxide; Lung; Male; Malondialdehyde; Methylcholanthrene; Microsomes; Oxygen; Phenobarbital; Pulmonary Edema; Random Allocation; Rats; Rats, Inbred Strains; Superoxides | 1988 |
Alteration of methylcholanthrene-mediated suppression of cutaneous delayed hypersensitivity by benzoflavone treatment of C57BL/6J mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dinitrofluorobenzene; Dose-Response Relationship, Drug; Drug Hypersensitivity; Enzyme Induction; Female; Flavonoids; Hypersensitivity, Delayed; Immunosuppressive Agents; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Phenobarbital; Polycyclic Compounds; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1988 |
Transplacental induction of cytochromes P-450IA1 and P-450IA2 by polycyclic aromatic carcinogens: TCDD-binding protein level as the rate-limiting step.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; Female; Gene Expression Regulation; Liver; Male; Maternal-Fetal Exchange; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger | 1988 |
Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture.
Topics: Albumins; Animals; Cell Division; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Glucose-6-Phosphatase; Liver; Male; Methylcholanthrene; Methyldimethylaminoazobenzene; Phenobarbital; Rats; Time Factors; Tyrosine Transaminase | 1985 |
Kinetic constant determination of liver microsomal and purified UDP-glucuronosyltransferase after phenobarbital and 3-methylcholanthrene treatments in rats.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; In Vitro Techniques; Kinetics; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Survival; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred F344 | 1986 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Karyotyping; Liver Neoplasms, Experimental; Methylcholanthrene; NADP; Neoplasm Transplantation; Organoids; Phenobarbital; Phenotype; Rats; Tyrosine Transaminase | 1986 |
Interaction of famotidine with rat liver microsomes, a study showing less inhibition of drug metabolism than with cimetidine.
Topics: Aminopyrine N-Demethylase; Animals; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Histamine H2 Antagonists; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Thiazoles | 1986 |
Noninducibility of cytochrome P-450 in the earthworm Dendrobaena veneta.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Oligochaeta; Phenobarbital | 1986 |
Effect of dexamethasone on cytochrome P-450 mediated metabolism of 2-acetylaminofluorene in cultured rat hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Corticosterone; Cytochrome P-450 Enzyme System; Dexamethasone; Hydrocortisone; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Tyrosine Transaminase | 1987 |
In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme System; Famotidine; Histamine H2 Antagonists; Humans; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Spectrum Analysis; Thiadiazoles; Thiazoles | 1988 |
Monoclonal antibody-directed characterization of rat hepatic P450 catalyzing the omega-1 and omega-2 hydroxylation of prostaglandins.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Chromatography, Affinity; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Inducibility of glutathione S-transferases in hamsters.
Topics: Animals; Butylated Hydroxyanisole; Cats; Cricetinae; Dexamethasone; Dogs; Enzyme Induction; Ethanol; Glutathione Transferase; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Quail; Rabbits; Rats; Species Specificity; Stilbenes; Trout | 1989 |
Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d.
Topics: Animals; Antibodies; Chick Embryo; Cytochrome P-450 Enzyme System; Female; Hexachlorobenzene; Immunoblotting; Kidney; Methylcholanthrene; Microsomes, Liver; o-Aminoazotoluene; Oxazines; Oxidation-Reduction; Phenobarbital; Porphyrinogens; Rats; Uroporphyrinogens | 1989 |
Alkylating toxins and the liver plasma membrane calcium pump/calcium atpase.
Topics: Acetaminophen; Animals; Bromobenzenes; Calcium; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Homeostasis; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cytochrome P-450 Enzyme System; DNA; DNA Restriction Enzymes; Enzyme Induction; Gene Expression Regulation; Isoenzymes; Methylcholanthrene; Phenobarbital; Rats; Repetitive Sequences, Nucleic Acid; RNA, Messenger | 1985 |
Studies on the structure-activity relationships for the metabolism of polybrominated biphenyls by rat liver microsomes.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Polybrominated Biphenyls; Polychlorinated Biphenyls; Rats; Structure-Activity Relationship | 1985 |
Two-step purification of cytochrome P-450 from rat liver microsomes using high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Durapatite; Electrophoresis, Polyacrylamide Gel; Hydroxyapatites; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Effects of two cannabinoids on hepatic microsomal cytochrome P-450.
Topics: 5-Aminolevulinate Synthetase; Animals; Cannabidiol; Cannabinoids; Cytochrome P-450 Enzyme System; Dronabinol; Heme Oxygenase (Decyclizing); Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital | 1986 |
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature | 1987 |
Interaction of miconazole, ketoconazole and itraconazole with rat-liver microsomes.
Topics: Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme Inhibitors; Itraconazole; Ketoconazole; Kinetics; Male; Methylcholanthrene; Miconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Rats | 1987 |
Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes.
Topics: Aldehyde Dehydrogenase; Aldehydes; Benzaldehydes; Carcinoma, Hepatocellular; Cells, Cultured; Liver; Liver Neoplasms; Methylcholanthrene; NAD; Neoplasm Proteins; Phenobarbital; Substrate Specificity | 1987 |
Metabolic activation of hydralazine by rat liver microsomes.
Topics: Animals; Biotransformation; Electron Spin Resonance Spectroscopy; Hydralazine; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains | 1987 |
Effects of alkyl phosphorothioates on the hepatic microsomal mixed-function oxidase system in rats. Inhibition of drug-metabolizing enzyme activity and selective increase of NADPH-cytochrome c reductase activity.
Topics: Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Organothiophosphorus Compounds; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
A comparative study of the mutagenic activation of N-nitrosopropylamines by various animal species and man: evidence for a cytochrome P-450 dependent reaction.
Topics: Adult; Aniline Hydroxylase; Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; DNA; Dose-Response Relationship, Drug; Female; Humans; Liver; Macaca fascicularis; Macaca mulatta; Male; Mesocricetus; Methylation; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred Strains; Mutagens; Nitrosamines; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency.
Topics: Amphetamine; Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Hydroxylation; In Vitro Techniques; Male; Methamphetamine; Methimazole; Methylcholanthrene; Microsomes, Liver; Monoamine Oxidase Inhibitors; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline | 1986 |
[Cytochrome P-450 isoforms in the liver of rats treated with phenobarbital, 3-methylcholanthrene and Aroclor 1254 studied by monoclonal antibodies].
Topics: Animals; Antibodies, Monoclonal; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clone Cells; Cytochrome P-450 Enzyme System; Imidazoles; Immunization; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1986 |
[Protection of the pulmonary toxic effects of normobaric oxygen by inducers of cytochrome P450-linked monooxygenases].
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Oxygen; Oxygenases; Phenobarbital; Pulmonary Edema; Rats; Rats, Inbred Strains | 1986 |
Immunochemical evidences that hexachlorobenzene induces two forms of cytochrome P-450 in the rat liver microsomes.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Hexachlorobenzene; Immunodiffusion; Immunoelectrophoresis; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Effects of phenobarbital, 3-methylcholanthrene and polychlorinated biphenyls on sex-specific forms of cytochrome P-450 in liver microsomes of rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; Pharmaceutical Preparations; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Sex Factors; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone | 1986 |
The induction profile of three orally active imidazopyridine-containing cardiotonic agents in rat hepatic microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Body Weight; Cardiotonic Agents; Cytochrome P-450 CYP1A1; Enzyme Induction; Imidazoles; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organ Size; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
UDP-glucuronyltransferases and their toxicological significance.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cell Line; DNA Replication; Glucuronosyltransferase; Inactivation, Metabolic; Isoenzymes; Kinetics; Liver Regeneration; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Rats; Substrate Specificity | 1986 |
Purification and characterization of a form of cytochrome P-450 with high specificity for aflatoxin B1 from 3-methylcholanthrene-treated hamster liver.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Isoenzymes; Liver; Male; Mesocricetus; Methylcholanthrene; Molecular Weight; Mutagenicity Tests; Phenobarbital; Salmonella typhimurium | 1986 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Liver; Liver Neoplasms, Experimental; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Rats | 1986 |
The 3-methylcholanthrene-mimetic effect of 4,4'-dichlorobiphenyl-treatment on phenacetin-induced hepatic glutathione depletion and liver microsomal phenacetin O-deethylation in rats.
Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glutathione; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenacetin; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1986 |
[Separation and analysis of immunochemical properties of multiple forms of cytochrome P-450 from the rat liver].
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunodiffusion; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Difference in the effects of phenobarbital and 3-methylcholanthrene treatment on subunit composition of hepatic glutathione S-transferase in male and female rats.
Topics: Aging; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Glutathione Transferase; Immunodiffusion; In Vitro Techniques; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1987 |
Stereoselective metabolism of benzo[c]phenanthrene to the procarcinogenic trans-3,4-dihydrodiol.
Topics: Animals; Carcinogens; Circular Dichroism; Cytochrome P-450 Enzyme System; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Phenanthrenes; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Stereoisomerism | 1987 |
Metabolism of alkoxyphenoxazones by channel catfish liver microsomes: effects of phenobarbital, Aroclor 1254 and 3-methylcholanthrene.
Topics: Animals; Aroclors; Catfishes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dealkylation; Ictaluridae; Methylcholanthrene; Microsomes, Liver; Oxazines; Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Substrate Specificity | 1987 |
[The level and activity of molecular forms of monooxygenase P-450b and P-450c during their separate and consecutive induction in the liver].
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunodiffusion; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1987 |
Induction of hepatic cytochrome P-450c-dependent monooxygenase activities by dantrolene in rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Dantrolene; Enzyme Induction; Epoxide Hydrolases; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Heterogeneity of hepatic microsomal UDP-glucuronosyltransferases activities: use and comparison of differential inductions in some mammalian species.
Topics: Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Guinea Pigs; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Gunn; Rats, Inbred Strains | 1987 |
Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene.
Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Repression; Immunoassay; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone; Time Factors | 1987 |
Hepatic and extrahepatic metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor, of amphetamines in rats: sex and strain differences.
Topics: Amphetamines; Animals; Chromatography, Gas; Female; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenethylamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Selegiline; Sex Factors; Species Specificity | 1987 |
Metabolic activation of a protein pyrolysate promutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by rat liver microsomes and purified cytochrome P-450.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Quinoxalines; Rats; Rats, Inbred Strains; Subcellular Fractions | 1988 |
Induction of hepatic drug metabolizing enzymes by coal fly ash in rats.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Carbon; Coal; Coal Ash; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Cytosol; Enzyme Induction; Glutathione Transferase; Industrial Waste; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Particulate Matter; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--II. Conjugases.
Topics: Animals; Cell Division; Cell Separation; Epithelial Cells; Epithelium; Glucuronosyltransferase; Intestine, Small; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1988 |
Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Cholic Acid; Cholic Acids; Cytochrome P-450 Enzyme System; Cytosol; Liver; Male; Methylcholanthrene; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital; Propane; Quinone Reductases; Rats; Rats, Inbred Strains | 1988 |
Potentiation and suppression of mouse liver cytochrome P-450 isozymes during the acute-phase response induced by bacterial endotoxin.
Topics: Acute-Phase Reaction; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Induction; Inflammation; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred CBA; Microsomes, Liver; Oxygenases; Phenobarbital | 1988 |
Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamine.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Formaldehyde; Hydroxylation; Isoenzymes; Male; Methamphetamine; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Pharmacokinetics and toxicity of mitomycin C in rodents, given alone, in combination, or after induction of microsomal drug metabolism.
Topics: Animals; Drug Interactions; Half-Life; Male; Methylcholanthrene; Microsomes, Liver; Mitomycin; Mitomycins; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Effects of chlorobenzenes and their methyl sulfone metabolites on microsomal enzymes associated with drug metabolism in rat liver.
Topics: Animals; Chlorobenzenes; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; NADH Dehydrogenase; Phenobarbital; Rats; Rats, Inbred Strains; Sulfones | 1988 |
Altered activation/detoxication enzymology following neonatal diethylstilbestrol treatment.
Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Diethylstilbestrol; Enzyme Activation; Epoxide Hydrolases; Female; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; Sex Factors | 1988 |
1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals.
Topics: Acetaminophen; Acetone; Carmustine; Cell Survival; Deferoxamine; Drug Synergism; Enzyme Induction; Glutathione; Liver; Male; Maleates; Methylcholanthrene; Phenobarbital; Phenylenediamines | 1988 |
A simple method for assessment of rat cytochrome P-448 isozymes responsible for the mutagenic activation of carcinogenic chemicals.
Topics: Amines; Animals; Biotransformation; Carbon Tetrachloride; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Phenobarbital; Rats | 1988 |
Effects of induction on the metabolism and cytochrome P-450 binding of harman and other beta-carbolines.
Topics: Alkaloids; Animals; Carbolines; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Harmine; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Spectrophotometry | 1988 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachlorobenzene; Levulinic Acids; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxidoreductases; Phenobarbital; Porphyrias; Porphyrins; Uroporphyrinogen Decarboxylase; Uroporphyrinogens | 1988 |
Oxidative metabolism of 7-methoxy-2-nitro-naphtho[2,1-b]furan (R 7000) by the microsomal system isolated from 3-methylcholanthrene-induced rat liver.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Induction; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Nitrofurans; Phenobarbital; Rats; Rats, Inbred Strains; Solubility; Spectrum Analysis | 1988 |
Structure-bioactivation relationship of a series of podophyllotoxin derivatives.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme System; Etoposide; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Podophyllotoxin; Rats; Rats, Inbred Strains; Spectrophotometry; Structure-Activity Relationship; Teniposide | 1988 |
A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin.
Topics: Animals; Autoanalysis; Coumarins; Cytochrome P-450 Enzyme System; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitriles; Phenobarbital; Rats; Rats, Inbred F344 | 1988 |
Comparative metabolism of phenanthrene and benzo[f]quinoline by rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Methylcholanthrene; Microsomes, Liver; Phenanthrenes; Phenobarbital; Quinolines; Rats; Rats, Inbred Strains | 1988 |
Synthesis of sex-specific forms of cytochrome P-450 in rat liver is transiently suppressed by hepatic monooxygenase inducers.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Female; Flavonoids; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Rats, Inbred Strains; Reference Values; Sex Factors | 1988 |
Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--I. Monooxygenases.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cell Separation; Enzyme Induction; Epithelial Cells; Epithelium; Ethylmorphine-N-Demethylase; Intestine, Small; Kinetics; Male; Methylcholanthrene; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1988 |
Ontogenic development of 7-ethoxycoumarin and 7-ethoxyresorufin O-deethylase in the rat and effect of monoclonal antibodies.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Female; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Cytochrome P-450 Enzyme System; Dopamine; Homovanillic Acid; Inactivation, Metabolic; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxygenases; Phenobarbital; Pyridines | 1988 |
Induction of P-450 isoenzyme activities in Syrian golden hamster liver compared to rat liver as probed by the rate of 7-alkoxyresorufin-O-dealkylation.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Isoenzymes; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1988 |
Organ-specific, carcinogenic dibenzo[c,g]carbazole derivatives: discriminative response in S. typhimurium TA100 mutagenesis modulated by subcellular fractions of mouse liver.
Topics: Animals; Aroclors; Biotransformation; Carbazoles; Cytosol; Female; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mutagenicity Tests; Phenobarbital; Salmonella typhimurium; Subcellular Fractions | 1988 |
The effect of pyrazole, phenobarbital, ethanol and 3-methylcholanthrene pretreatment on the in vivo and in vitro genotoxicity of N-nitrosopyrrolidine.
Topics: Animals; DNA Damage; Ethanol; Liver; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Mutation; N-Nitrosopyrrolidine; Nitrosamines; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1988 |
Induction of cytochrome P-450 mRNA in rainbow trout: in vitro translation and immunodetection.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Immunosorbent Techniques; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Reference Values; RNA, Messenger; Salmonidae; Time Factors; Trout | 1988 |
Effect of liver enzyme inducers on metabolite excretion in rats treated with 1-nitropyrene.
Topics: Animals; Biotransformation; Feces; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Phenobarbital; Pyrenes; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1987 |
Comparative activation of 3,3'-dichlorobenzidine and related benzidines to mutagens in the Salmonella typhimurium assay by hepatic S9 and microsomes from rats pretreated with different inducers of cytochrome P-450.
Topics: 3,3'-Dichlorobenzidine; Animals; Benzidines; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship | 1987 |
Metabolic activation of 2-amino-3-methylimidazo(4,5-f)quinoline by hepatic preparations--contribution of the cytosolic fraction and its significance to strain differences.
Topics: Animals; Aroclors; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytosol; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; NAD; Phenobarbital; Quinolines; Rats; Rats, Inbred Strains; Species Specificity; Subcellular Fractions | 1986 |
Differential stereoselectivity on metabolism of triphenylene by cytochromes P-450 in liver microsomes from 3-methylcholanthrene- and phenobarbital-treated rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chrysenes; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxygen Isotopes; Phenanthrenes; Phenobarbital; Rats; Stereoisomerism; Structure-Activity Relationship | 1988 |
Induction of hepatic drug-metabolizing enzymes in rats treated with 1-nitropyrene.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pyrenes; Rats; Rats, Inbred Strains | 1988 |
Metabolism of benz[j]aceanthrylene (cholanthrylene) and benz[l]aceanthrylene by induced rat liver S9.
Topics: Animals; Aroclors; Benz(a)Anthracenes; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Liver; Methylcholanthrene; Phenobarbital; Rats | 1988 |
Oxidative metabolism of the carcinogen 6-fluorobenzo[c]phenanthrene. Effect of a K-region fluoro substituent on the regioselectivity of cytochromes P-450 in liver microsomes from control and induced rats.
Topics: Animals; Binding Sites; Carcinogens; Cytochrome P-450 Enzyme System; Hydrocarbons, Fluorinated; Magnetic Resonance Spectroscopy; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Oxidation-Reduction; Phenanthrenes; Phenobarbital; Protein Binding; Rats; Reference Values; Structure-Activity Relationship | 1988 |
Regulation of hepatic haem metabolism. Disparate mechanisms of induction of haem oxygenase by drugs and metals.
Topics: Animals; Cations, Divalent; Cells, Cultured; Chick Embryo; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Glutethimide; Heme; Heme Oxygenase (Decyclizing); Liver; Mephenytoin; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Porphyrins | 1988 |
Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Body Weight; Chlorobenzenes; Enzyme Induction; Glutathione Transferase; Hexachlorobenzene; Isoenzymes; Isothiocyanates; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Rats, Inbred Strains; Thiocyanates | 1988 |
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity | 1988 |
[Isolation and comparative analysis of multiple isoenzymes of glutathione-S-transferase from the liver of intact rats and rats administered phenobarbital, 3-methylcholanthrene and butylhydroxytoluene].
Topics: Animals; Butylated Hydroxytoluene; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Glutathione Transferase; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1988 |
Genetic differences in response to pulmonary cytochrome P-450 inducers and oxygen toxicity.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Oxygen; Phenobarbital; Pulmonary Edema; Species Specificity | 1988 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains.
Topics: Animals; Dexamethasone; Dioxins; Estradiol; Genes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Organ Size; Organ Specificity; Phenobarbital; Polychlorinated Dibenzodioxins; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogenes; Species Specificity; Thymus Gland; Transcription, Genetic | 1988 |
Loss of 3-methylcholanthrene-inducible form of cytochrome P-450 in liver microsomes following administration of carbon disulfide in C57BL/6 Cr mice.
Topics: Animals; Carbon Disulfide; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital | 1988 |
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits.
Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Rabbits | 1988 |
Secondary structure prediction of liver microsomal cytochrome P-450; proposed model of spatial arrangement in a membrane.
Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Membranes; Methylcholanthrene; Microsomes, Liver; Models, Chemical; Phenobarbital; Protein Conformation; Rabbits | 1988 |
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dipyrone; Female; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains | 1988 |
Effect of phenobarbital & 3-methylcholanthrene treatment on thyroid hormones in rat.
Topics: Animals; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyroxine; Triiodothyronine | 1987 |
Effect of microsomal enzyme inducers on the urinary excretion pattern of mutagenic metabolites of the carcinogen 2,4-toluenediamine.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carcinogens; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Phenobarbital; Phenylenediamines; Rats; Rats, Inbred F344 | 1986 |
Selective induction and inhibition of the components of 7-ethoxycoumarin O-deethylase activity in the rat.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Monoclonal antibody characterization of hepatic and extrahepatic cytochrome P-450 activities in rats treated with phenobarbital or methylcholanthrene and fed various cholesterol diets.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Aryl Hydrocarbon Hydroxylases; Cholesterol, Dietary; Cytochrome P-450 Enzyme System; Enzyme Induction; Intestinal Mucosa; Isoenzymes; Lung; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Monoclonal antibody-directed analysis of cytochrome P-450-dependent monooxygenases and mutagen activation in the livers of DBA/2 and C57BL/6 mice.
Topics: Animals; Antibodies, Monoclonal; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Activation; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Mutagenicity Tests; Phenobarbital; Pregnenolone Carbonitrile; Salmonella typhimurium | 1986 |
Analysis of debromination of 1,2-dibromoethane by cytochrome P-450-linked hydroxylation systems as observed by bromide electrode.
Topics: Animals; Bromides; Bromine; Cytochrome P-450 Enzyme System; Electrodes; Enzyme Activation; Ethylene Dibromide; Guinea Pigs; Hydrocarbons, Brominated; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits | 1986 |
In vitro activation of isophosphamide and trophosphamide to metabolites mutagenic for bacteria.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cyclophosphamide; Drug Interactions; Ifosfamide; Liver; Male; Methylcholanthrene; Monoamine Oxidase Inhibitors; Mutagenicity Tests; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1986 |
Localization of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in mouse lung with monoclonal antibodies.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal; Antibody Specificity; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorescent Antibody Technique; Isoenzymes; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Phenobarbital; Rats | 1986 |
Immunological identification and effects of 3-methylcholanthrene and phenobarbital on rat pulmonary cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunoenzyme Techniques; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
In vivo and in vitro hepatotoxicity and metabolism of acetaminophen in Syrian hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chromatography, High Pressure Liquid; Cricetinae; Enzyme Induction; In Vitro Techniques; Kinetics; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Methylcholanthrene; Phenobarbital | 1987 |
Phenacetin O-deethylase activity of the rat: strain differences and the effects of enzyme-inducing compounds.
Topics: Animals; Cytochrome P-450 CYP1A2; Enzyme Induction; Female; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Subcellular Fractions | 1987 |
Effect of excessive intake of ascorbic acid on hepatic and extra-hepatic phase I and phase II drug metabolism in rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Colon; Cytochrome P-450 Enzyme System; Glutathione Transferase; Liver; Lung; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Maintenance of nicotinamide dinucleotide phosphate content and oxidation-reduction state during mixed-function oxidation of p-nitroanisole in isolated perfused livers of various species.
Topics: Animals; Anisoles; Cricetinae; Female; Kinetics; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Phenobarbital; Precancerous Conditions; Rats | 1987 |
Fasciola hepatica: liver enzymes in rats and interaction with chemical inducers.
Topics: Animals; Arylamine N-Acetyltransferase; Biotransformation; Calcium; Cytochrome P-450 Enzyme System; Cytosol; Fasciola hepatica; Fascioliasis; Glutathione; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
Changes in hepatic dolichol and dolichyl monophosphate caused by treatment of rats with inducers of the endoplasmic reticulum and peroxisomes and during ontogeny.
Topics: 2-Acetylaminofluorene; Animals; Cell Compartmentation; Cholestyramine Resin; Cytochrome P-450 Enzyme System; Diethylamines; Diterpenes; Dolichol Phosphates; Dolichols; Hexosyltransferases; Liver; Liver Regeneration; Methylcholanthrene; Microbodies; Microsomes, Liver; NADH Dehydrogenase; Phenobarbital; Phthalic Acids; Polyisoprenyl Phosphates; Rats; Turpentine | 1987 |
The effect of age on mono-oxygenase enzyme kinetics in rat liver microsomes.
Topics: Aging; Aldrin; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Kinetics; Methylcholanthrene; Microsomes, Liver; Oxazines; Phenobarbital; Rats | 1987 |
Metabolism of dibenz[a,h]acridine by rat liver microsomes.
Topics: Acridines; Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Long-term maintenance of hepatocytes in primary culture in the presence of DMSO: further characterization and effect of nafenopin, a peroxisome proliferator.
Topics: Animals; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; DNA; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Methylcholanthrene; Microbodies; Microscopy, Electron; Nafenopin; Oxidoreductases; Palmitoyl Coenzyme A; Phenobarbital; Propionates; Rats; Rats, Inbred Strains | 1987 |
[Induction of the monooxygenase system and the transport of xenobiotics in the kidney].
Topics: Animals; Barbiturates; Enzyme Induction; Kidney Tubules; Methylcholanthrene; Oxygenases; Phenobarbital; Rats | 1987 |
Phenobarbital depression of hepatic microsomal benzo[a]pyrene hydroxylation in rats starved and refed a diet containing menhaden fish oil: substrate and fat level dependency.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Dietary Fats; Fish Oils; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1987 |
Effect of microsomal enzyme activity modulation on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity.
Topics: Animals; Drug Interactions; Enzyme Induction; Kidney; Male; Methylcholanthrene; Microsomes; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity; Succinimides | 1987 |
Metabolism of caffeine to 6-amino-5-[N-methylformylamino]-1,3-dimethyluracil in the isolated, perfused liver from control or phenobarbital-, beta-naphthoflavone- and 3-methylcholanthrene-pretreated rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Drug Interactions; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Uracil | 1987 |
Metabolism of 1-phthalidyl 5-fluorouracil in rat liver and enzyme induction by phenobarbital.
Topics: Aldehyde Oxidoreductases; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability; Enzyme Induction; Fluorouracil; Hydrolases; In Vitro Techniques; Liver; Male; Methylcholanthrene; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains; Sarcoma, Experimental | 1987 |
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and Drug Induced Liver Injury; Cimetidine; Dose-Response Relationship, Drug; Insecticides; Male; Methylcholanthrene; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Plants; Proadifen; Rats; Rats, Inbred Strains | 1987 |
Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bile; Diflunisal; Esters; Ethers; Glucuronates; Hydrogen-Ion Concentration; Male; Metabolic Clearance Rate; Methylcholanthrene; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Salicylates | 1987 |
Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment.
Topics: Animals; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1987 |
[The role of vitamin K3 in the hydroxylation of benz(a)pyrene in rat liver mitochondria after induction with 3-methylcholanthrene and phenobarbital].
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Vitamin K | 1987 |
Xenobiotic metabolizing enzymes are not restricted to parenchymal cells in rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Aroclors; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Endothelium; Epoxide Hydrolases; Glutathione Transferase; Kupffer Cells; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1987 |
Parathion toxicity in relation to liver microsomal oxidases, lipid composition and fluidity.
Topics: Animals; Dietary Fats; Lipids; Male; Membrane Fluidity; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Parathion; Phenobarbital; Rats; Rats, Inbred Strains | 1987 |
The effects of cigarette smoke compared to 3-methylcholanthrene and phenobarbitone on alkoxyresorufin metabolism by lung and liver microsomes from rats.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; In Vitro Techniques; Lung; Male; Methylcholanthrene; Microsomes, Liver; Nicotiana; Oxazines; Oxidoreductases; Phenobarbital; Plants, Toxic; Rats; Rats, Inbred Strains; Smoke | 1987 |
Synergy of phenobarbital and 3-methylcholanthrene in "superinduction" of cytochrome P-450c mRNA but not enzyme activity.
Topics: Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Messenger | 1987 |
Metabolism of benzo[f]quinoline by rat liver microsomes.
Topics: Animals; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Quinolines; Rats; Rats, Inbred Strains | 1987 |
Expression of genes encoding glutathione S-transferases in normal and preneoplastic liver.
Topics: Animals; Gene Expression Regulation; Glutathione Transferase; Liver; Liver Neoplasms; Methylcholanthrene; Phenobarbital; Precancerous Conditions; Rats; RNA, Messenger | 1987 |
Different effects of chemicals on metabolism of N-nitrosamines in rat liver.
Topics: Animals; Dimethylnitrosamine; Ethanol; Liver; Methylcholanthrene; Nitrosamines; Phenobarbital; Pyrazoles; Rats | 1987 |
Hexachlorobenzene-induced oxygen activation by mouse liver microsomes: comparison with phenobarbitone and 20-methylcholanthrene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxygen; Phenobarbital | 1987 |
Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats.
Topics: 5-Aminolevulinate Synthetase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Antipyrine; Biotransformation; Cycloparaffins; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Trimethadione | 1987 |
Enzyme induction in rat lung and liver by condensates and fractions from main-stream and side-stream cigarette smoke.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mutagenicity Tests; Nicotiana; Oxidoreductases, N-Demethylating; Phenobarbital; Plants, Toxic; Rats; Rats, Inbred Strains; Smoke; Spectrometry, Fluorescence; Spectrophotometry | 1987 |
Changes in cytochrome P450 molecular species in rat liver in chloroform intoxication.
Topics: Animals; Carbon Tetrachloride; Chloroform; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Destruction of cytochrome P-450 and formation of green pigments by contraceptive steroids in rat hepatocyte suspensions.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Humans; Liver; Male; Methylcholanthrene; Norethindrone; Phenobarbital; Pigments, Biological; Proadifen; Rats; Rats, Inbred F344; Steroids; Structure-Activity Relationship; Suspensions; Time Factors | 1986 |
Dependence of benzo[a]pyrene metabolic profile on the concentration of cumene hydroperoxide with uninduced and induced rat liver microsomes.
Topics: Animals; Aroclors; Benzene Derivatives; Benzo(a)pyrene; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
The role of drug metabolism in cyclosporine A nephrotoxicity.
Topics: Aminopyrine N-Demethylase; Animals; Cyclosporins; Cytochrome P-450 Enzyme System; Enzyme Induction; Kidney Diseases; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1986 |
[Determination of phenathrene-9,10-epoxidase in the liver microsomes of rats. The effect of induction on the activity of the enzyme].
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Detergents; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenanthrenes; Phenobarbital; Polidocanol; Polyethylene Glycols; Rats; Rats, Inbred Strains | 1986 |
Stereoselective metabolism of 9-methyl-, 9-hydroxymethyl- and 9,10-dimethylanthracenes: absolute configurations and optical purities of trans-dihydrodiol metabolites.
Topics: Animals; Anthracenes; Chromatography, High Pressure Liquid; Circular Dichroism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism | 1986 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
Dual ligand binding of pyridylalkanamides to microsomal cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Male; Mathematics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Different depressing effects of lentinan on the increases of cytochrome P-450-dependent monooxygenase activities induced in mice by phenobarbital and by 3-methylcholanthrene.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Lentinan; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mixed Function Oxygenases; Phenobarbital; Polysaccharides | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e.
Topics: Cytochrome P-450 Enzyme System; Gene Expression Regulation; Kidney; Liver; Lung; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; RNA, Messenger; Testis | 1986 |
A comparative study of the regulation of cytochrome P-450 and glutathione transferase gene expression in rat liver.
Topics: Amitrole; Animals; Cell Nucleus; Cobalt; Cytochrome P-450 Enzyme System; DNA; Gene Expression Regulation; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Biosynthesis; Rats; Time Factors; Transcription, Genetic | 1986 |
Oxidative microsomal metabolism of 1-nitropyrene and DNA-binding of oxidized metabolites following nitroreduction.
Topics: Acetylation; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; DNA; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pyrenes; Rats; Rats, Inbred Strains; Stilbenes; Xanthine Oxidase | 1986 |
Induction and catalytic activities of cytochromes P-450b/e and P-450c in the liver microsomes of neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Kinetics; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Expression and sequence analysis of rat liver glutathione S-transferase genes.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA; Genes; Glutathione Transferase; Liver; Methylcholanthrene; Nucleic Acid Hybridization; Phenobarbital; Plasmids; Rats; RNA, Messenger | 1986 |
Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins.
Topics: Aminopyrine; Animals; Apoproteins; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dicarbethoxydihydrocollidine; Formaldehyde; Formates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Testosterone | 1986 |
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives.
Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole | 1986 |
3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.
Topics: Animals; Azirines; Benzoflavones; beta-Naphthoflavone; Binding Sites; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Iodine Radioisotopes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Photochemistry; Rats | 1986 |
Effects of inducers on the regio- and stereoselective metabolism of benzo[a]pyrene by mouse tissue microsomes.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Drug Interactions; Injections, Intraperitoneal; Liver; Lung; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Skin | 1986 |
Testosterone metabolite profiles reveal differences in the spectrum of cytochrome P-450 isozymes induced by phenobarbitone, 2-acetylaminofluorene and 3-methylcholanthrene in the chick embryo liver.
Topics: 2-Acetylaminofluorene; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; In Vitro Techniques; Isoenzymes; Liver; Methylcholanthrene; Phenobarbital; Testosterone | 1986 |
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.
Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole | 1986 |
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Ethanol; Female; Humans; Imidazoles; Kinetics; Liver; Male; Methylcholanthrene; Nucleic Acid Hybridization; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains; Species Specificity | 1986 |
On the inducibility of cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Phenobarbital | 1986 |
Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats.
Topics: Administration, Oral; Aminopyrine; Animals; Aroclors; Carbon Tetrachloride; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hexobarbital; Isoenzymes; Liver; Male; Metabolic Clearance Rate; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
[Identification and characteristics of mRNA for cytochrome P-450 in the rat liver induced by phenobarbital and 3-methylcholanthrene].
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Isoenzymes; Liver; Methylcholanthrene; Phenobarbital; Rats; RNA, Messenger | 1986 |
Total cytochrome P-450, but not the major phenobarbitone or 3-methylcholanthrene induced isoenzyme, is differentially induced in the lobes of the rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Tissue Distribution | 1987 |
Enzymatic detoxication of DDT to DDD by rat liver: effects of some inducers and inhibitors of cytochrome P-450 enzyme system.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DDT; Dichlorodiphenyldichloroethane; Enzyme Induction; Hydrogen-Ion Concentration; Inactivation, Metabolic; Liver; Methylcholanthrene; Phenobarbital; Rats; Temperature | 1987 |
Dibenz [a,j]acridine: distributions of metabolites formed by liver and lung microsomes from control and pretreated rats.
Topics: Acridines; Animals; Biotransformation; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes | 1987 |
Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Body Weight; Cytochrome P-450 CYP1A1; Dioxins; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Proteins; Rats; Rats, Inbred Strains; Stereoisomerism; Steroid Hydroxylases | 1985 |
Use of rodent hepatocytes for metabolic activation in transformation assays.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Liver; Methylcholanthrene; Mice; Phenobarbital; Rats; Species Specificity | 1985 |
Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethers, Cyclic; Isoenzymes; Male; Mathematics; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
Benznidazole and nifurtimox nitroreductase activity in liver microsomes from male rats preinduced with phenobarbital or 3-methylcholanthrene.
Topics: Animals; Biotransformation; Male; Methylcholanthrene; Microsomes, Liver; Nifurtimox; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Increased response of cytochrome P-450 dependent biotransformation reactions in rat liver to repeated administration of inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Identification of the forms of cytochrome P-450 induced in rat liver by 2-acetylaminofluorene using immunoblotting and partial purification.
Topics: 2-Acetylaminofluorene; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immunosorbent Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Enzyme Induction; Flavonoids; Glucuronates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Separation of different UDP glucuronosyltransferase activities according to charge heterogeneity by chromatofocusing using mouse liver microsomes. Three major types of aglycones.
Topics: Animals; Chromatography, Ion Exchange; Enzyme Induction; Glucuronosyltransferase; Hydrogen-Ion Concentration; Isoelectric Focusing; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital | 1985 |
Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake, and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: a comparative study.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Ethanol; Food Deprivation; Hydrocarbons; Liver; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Proteins; Rats; Rats, Inbred Strains; Volatilization | 1985 |
Reconstituted halogenated hydrocarbon pesticide and pollutant mixtures found in human tissues: effects on the immature male Wistar rat after short-term exposure.
Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Environmental Pollutants; Humans; Hydrocarbons, Halogenated; Male; Methylcholanthrene; Microsomes, Liver; Pesticide Residues; Pesticides; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1985 |
Induction of drug metabolizing enzymes in human liver cell line Hep G2.
Topics: Cell Line; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Humans; Isoenzymes; Liver; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Sulfurtransferases | 1985 |
Heterogeneity of hepatic microsomal UDP-glucuronosyltransferase activities. Conjugations of phenolic and monoterpenoid aglycones in control and induced rats and guinea pigs.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Guinea Pigs; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenols; Rats; Rats, Gunn; Rats, Inbred Strains; Structure-Activity Relationship; Terpenes | 1985 |
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity | 1985 |
Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Peptide Fragments; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity; Trypsin | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
Hepatic presystemic elimination of diethylstilbestrol by rats and effect of pretreatment with inducers of UDP-glucuronosyltransferase.
Topics: Animals; Bile; Diethylstilbestrol; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1985 |
Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Fetus; Hydroxylation; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Sex Factors | 1986 |
Studies on rat liver cytochrome P-450s involved in the metabolism of antipyrine: phenobarbital- and 3-methylcholanthrene-inducible isozymes possessing 4-hydroxylase activity.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Isoenzymes; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Female; Hydroxylation; In Vitro Techniques; Lactation; Mammary Glands, Animal; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1985 |
Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene.
Topics: Animals; Aroclors; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Chlorophenols; Chromatography, High Pressure Liquid; Female; Hexachlorobenzene; Male; Methylcholanthrene; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
The activation and DNA binding of 7-methylbenz[c]-acridine catalysed by mouse liver microsomes.
Topics: Acridines; Animals; Carcinogens; Catalysis; Cattle; Chromatography, High Pressure Liquid; DNA; In Vitro Techniques; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Time Factors | 1985 |
Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate.
Topics: Animals; Disulfiram; Ethoxyquin; Glutathione; Inactivation, Metabolic; Lethal Dose 50; Lobeline; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Proadifen | 1985 |
The metabolism of the carcinogen 7-methylbenz[c]acridine by hepatocytes isolated from untreated and induced rats.
Topics: Acridines; Animals; Carcinogens; Enzyme Induction; Glucuronidase; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.
Topics: Aminopyrine N-Demethylase; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxazines; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Substrate Specificity | 1985 |
Relation between hepatic microsomal metabolism of N-nitrosamines and cytochrome P-450 species.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains | 1985 |
Altered induction response of hepatic cytochrome P-450 to phenobarbital, 3-methylcholanthrene, and beta-naphthoflavone in organotin-treated animals.
Topics: 5-Aminolevulinate Synthetase; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Environmental Exposure; Enzyme Induction; Flavonoids; Liver; Male; Methylcholanthrene; Organotin Compounds; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1985 |
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN).
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone.
Topics: Administration, Oral; Animals; Cyclohexane Monoterpenes; Cytochrome P-450 Enzyme System; Kinetics; Male; Menthol; Methylcholanthrene; Microsomes, Liver; Monoterpenes; NADP; Phenobarbital; Rats; Time Factors | 1985 |
Ultrastructural and immunohistochemical studies on non-ciliated cells of the tracheal epithelium of normal, phenobarbital-treated and 3-methylcholanthrene-treated mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Epithelium; Histocytochemistry; Male; Methylcholanthrene; Mice; Phenobarbital; Trachea | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Additional routes in the metabolism of phenacetin.
Topics: Acetylation; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; Female; Hydroxylation; In Vitro Techniques; Liver; Magnetic Resonance Spectroscopy; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenacetin; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains | 1985 |
Benzene myeloclastogenicity: a function of its metabolism.
Topics: Animals; Benzene; Benzoflavones; beta-Naphthoflavone; Bone Marrow; Catechols; Chromosome Aberrations; Enzyme Induction; Female; Germ-Free Life; Hydroquinones; Male; Methylcholanthrene; Mice; Mixed Function Oxygenases; Phenobarbital; Phenol; Phenols; Sex Factors | 1985 |
Xenobiotic imprinting of hepatic metabolic enzyme systems: effect of neonatal 3-methylcholanthrene administration.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
A study into the effects of 2-acetylaminofluorene on hepatic monooxygenase activities in the chick embryo.
Topics: 2-Acetylaminofluorene; Acetylation; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Hydroxylation; Liver; Methylcholanthrene; Oxygenases; Phenobarbital | 1985 |
The binding of isocyanides to cytochrome P-450 from mouse hepatic microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Microsomes, Liver; Nitriles; Phenobarbital; Protein Binding | 1985 |
Structural features of imidazole derivatives that enhance styrene oxide hydrolase activity in rat hepatic microsomes.
Topics: Animals; Antifungal Agents; Enzyme Activation; Epoxide Hydrolases; Imidazoles; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1985 |
The effects of short-term administration of ibuprofen on trimethadione metabolism and antipyrine metabolite formation in the rat.
Topics: Animals; Antipyrine; Ibuprofen; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Trimethadione | 1985 |
Effects of 3-methylcholanthrene and phenobarbital on the capacity of embryos to bioactivate teratogens during organogenesis.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Animals; Biotransformation; Cyclophosphamide; Embryo, Mammalian; Female; Male; Methylcholanthrene; Microsomes, Liver; Organ Culture Techniques; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1985 |
In vitro metabolism of diethylstilbestrol by hepatic, renal and uterine microsomes of rats and hamsters. Effects of different inducers.
Topics: Animals; Benzoflavones; Biotransformation; Chromatography, High Pressure Liquid; Cricetinae; Diethylstilbestrol; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Kidney; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Uterus | 1985 |
Resolution of multiple P-450 forms: separation of aryl hydrocarbon hydroxylase and aminopyrine N-demethylase-associated P-450 isoenzymes by chromatofocusing.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Chromatography; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Isoelectric Point; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
[Induction of cytochrome P-450 forms in liver microsomes of rats in the early neonatal period after administration of phenobarbital and 3-methylcholanthrene].
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Effects of pretreatment with pyrazole and inducers of mixed function oxidases on DNA repair elicited by dimethylnitrosamine in rat hepatocytes in vivo and in vitro.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; DDT; Diethylnitrosamine; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Liver; Male; Methyl Methanesulfonate; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Methyl ethyl ketone peroxide damage to cytochrome P-450 peroxidase activities.
Topics: Animals; Butanones; Kidney; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Peroxidases; Peroxides; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole | 1985 |
Multiple forms of cytochrome P-450 from microsomes of rat liver, kidney, and lung resolved by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; In Vitro Techniques; Isoenzymes; Kidney; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
[Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Catalysis; Cell Nucleus; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Endoplasmic Reticulum; Enzyme Induction; Intracellular Membranes; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1985 |
Rat liver subcellular fractions catalyze aerobic binding of 1-nitro[14C]pyrene to DNA.
Topics: Aerobiosis; Animals; Aroclors; Carbon Radioisotopes; Cattle; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Cytosol; DNA; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pyrenes; Rats; Subcellular Fractions; Thymus Gland | 1985 |
The effect of indomethacin on hepatic drug-oxidizing capacity in the rat: trimethadione and antipyrine metabolism as an indicator.
Topics: Animals; Antipyrine; Half-Life; Indomethacin; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxazoles; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Trimethadione | 1985 |
Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Oxazines; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1985 |
Properties of cytochrome P-450 as affected by environmental factors: qualitative changes due to administration of polycyclic hydrocarbons.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Cyanides; Cytochromes; Electron Transport; Environment; Hydrocarbons; Hydrogen-Ion Concentration; Methylcholanthrene; Microsomes, Liver; Morpholines; Phenobarbital; Polycyclic Compounds; Spectrum Analysis; Thyroxine | 1971 |
Characteristics of nitro reduction of the carcinogenic agent, 4-nitroINOLONE N-oxide.
Topics: Alcohol Oxidoreductases; Animals; Benzoates; Carcinogens; Dicumarol; Flavin Mononucleotide; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Oxides; Oxidoreductases; Oxygen; Phenobarbital; Quinolines; Rats; Time Factors | 1970 |
Comparison of the efficacy of pretreatment protection against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and by 7-methyl-12-methylbenz(a)anthracene in rats.
Topics: Adrenal Glands; Aminoglutethimide; Animals; Azo Compounds; Benz(a)Anthracenes; Chlorpromazine; Coloring Agents; Dichlorodiphenyldichloroethane; Female; Glutethimide; Injections, Intraperitoneal; Injections, Intravenous; Intubation, Gastrointestinal; Methylcholanthrene; Necrosis; p-Dimethylaminoazobenzene; Phenobarbital; Polycyclic Compounds; Rats; Sodium; Time Factors | 1969 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. I. Stimulation of enzyme activity in nonhepatic cells and in hepatic cells by phenobarbital, polycyclic hydrocarbons, and 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carbon Isotopes; Cells, Cultured; Chick Embryo; Chromatography, Thin Layer; Cricetinae; DDT; Enzyme Induction; Extremities; Fetus; Gestational Age; Half-Life; Intestines; Kinetics; Liver; Lung; Methylcholanthrene; Mice; Mixed Function Oxygenases; Phenobarbital; Polycyclic Compounds; Protein Biosynthesis; Rabbits; Rats; RNA; Species Specificity; Time Factors; Tritium; Uridine | 1971 |
The histochemical demonstration of aniline hydroxylase activity in rat liver.
Topics: Acetone; Aniline Compounds; Animals; Carbon Monoxide; Cyanides; Diazonium Compounds; Ethanol; Female; Formaldehyde; Histocytochemistry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrogen; Phenobarbital; Phenols; Rats; Staining and Labeling; Time Factors | 1971 |
The role of the portal of entry in inhibition of tumorigenesis.
Topics: Animals; Azoles; Benzopyrenes; Biotransformation; Carcinogens; Diet; Dietary Fats; Environmental Pollution; Enzyme Induction; Flavonoids; Histocytochemistry; Hydrocarbons; Intestine, Small; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Neoplasms; Phenobarbital; Phenothiazines; Placenta; Polycyclic Compounds; Protein Binding; Rats; Rats, Inbred Strains; Skin; Thiazoles | 1971 |
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.
Topics: Aging; Animals; Benzopyrenes; Carbon Monoxide; Crosses, Genetic; Cytochromes; Enzyme Induction; Female; Genotype; Hydrogen-Ion Concentration; Kidney; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Molecular Biology; Oxygenases; Phenobarbital; Phenotype; Polycyclic Compounds; Pregnancy | 1972 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. 3. Effects of various sera, hormones, biogenic amines, and other endogenous compounds on the enzyme activity.
Topics: Animals; Blood; Carbon Isotopes; Cattle; Cells, Cultured; Culture Media; Dexamethasone; Drug Synergism; Enzyme Induction; Estradiol; Female; Glucagon; Insulin; Liver; Methylcholanthrene; Mixed Function Oxygenases; Norepinephrine; Phenobarbital; Polycyclic Compounds; Prostaglandins; Protein Biosynthesis; Rats; RNA; Testosterone; Tritium | 1972 |
Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450.
Topics: Amines; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Genetics; Kidney; Liver; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NZB; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenotype; Polycyclic Compounds; Protein Binding; Rats | 1972 |
Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Hydroxylation; Kidney; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NZB; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polycyclic Compounds; Protein Binding; Pyridines; Spectrophotometry | 1972 |
N-ethylmaleimide adduct of 7,12-dimethylbenzanthracene. Properties and metabolism by rat liver microsomes.
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Carbon Isotopes; Chromatography, Thin Layer; Enzyme Induction; Estradiol; Ethylmaleimide; Male; Mammary Neoplasms, Experimental; Methylcholanthrene; Microsomes, Liver; Necrosis; Phenobarbital; Polycyclic Compounds; Rats; Spectrophotometry, Ultraviolet | 1972 |
Multiplicity of cytochrome P450 hemoproteins in rat liver microsomes.
Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Sodium Dodecyl Sulfate; Staining and Labeling; Time Factors | 1974 |
[Selective induction of a liver microsomal mixed-function oxygenase system. II. Kinetic study of benz(a)pyrene hydroxylase].
Topics: Animals; Benzopyrenes; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pyrenes; Rats | 1974 |
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats | 1973 |
Effects of Triton X-100 on drug hydroxylation system of rat liver microsomes induced by phenobarbital or 3-methylcholanthrene.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Enzyme Activation; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Surface-Active Agents | 1972 |
Induction of liver microsomal drug metabolism in newly-hatched chicks.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Animals, Newborn; Chick Embryo; Chickens; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Phenobarbital; Time Factors | 1973 |
Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.
Topics: Aminopyrine N-Demethylase; Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen; Oxidoreductases; Phenobarbital; Rats; Riboflavin Deficiency | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium | 1973 |
Electron transport components of hepatic microsomes. Solubilization, resolution, and recombination to reconstitute aniline hydroxylase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Chloromercuribenzoates; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats; Solubility; Structure-Activity Relationship; Vitamin K | 1973 |
Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction.
Topics: Aminopyrine; Animals; Azides; Catalase; Cytochrome P-450 Enzyme System; Hemeproteins; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1973 |
Induction of UDP glucuronyltransferase in the liver and extrahepatic organs of the rat.
Topics: Animals; Body Weight; Chlorpromazine; Digitonin; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Quinolines; Rats; Serum Albumin, Bovine; Spleen | 1973 |
Lipid peroxidation and the degradation of cytochrome P-450 heme.
Topics: Aminopyrine; Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Levulinic Acids; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Pentobarbital; Peroxidases; Phenobarbital; Protein Binding; Rats; Secobarbital; Spectrophotometry; Time Factors; Tritium | 1973 |
Preparation of partially purified, lipid-depleted cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rat liver microsomes.
Topics: Animals; Cholic Acids; Chromatography, DEAE-Cellulose; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Detergents; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Rats; Spectrophotometry; Ultrafiltration | 1974 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
Studies of the binding of sulfur released in the mixed-function oxidase-catalyzed metabolism of diethyl p-nitrophenyl phosphorothionate(parathion) to diethyl p-nitrophenyl phosphate (paraoxon).
Topics: Animals; Benzphetamine; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dealkylation; Esterases; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Solvents; Sulfur; Sulfur Radioisotopes | 1974 |
The specificity of the rat-liver cholesterol 7alpha-hydroxylase.
Topics: Alcohol Oxidoreductases; Aminopyrine N-Demethylase; Androstenols; Animals; Cholesterol; Cholestyramine Resin; Cycloheximide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; Phenobarbital; Pregnenolone; Protein Binding; Rats; Time Factors | 1974 |
[Influence of ethanol on the metabolism of drugs].
Topics: Aldrin; Animals; Benzopyrenes; Carcinogens; DDT; Drug Interactions; Ethanol; Histamine H1 Antagonists; Insecticides; Methylcholanthrene; Nikethamide; Pharmaceutical Preparations; Phenobarbital; Phenothiazines; Rats; Tolbutamide | 1969 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA.
Topics: Aflatoxins; Animals; Benzopyrans; Benzopyrenes; Binding Sites; Carbon Radioisotopes; DNA; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Spectrum Analysis; Tritium | 1974 |
Inhibition of hepatic mixed function oxidase activity by propyl gallate.
Topics: Aging; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Benzphetamine; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Diet; Gallic Acid; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Cytochrome c Group; Cytochrome Reductases; Cytosol; Dialysis; Electron Transport; Female; Hydrazines; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Nitrofurans; Nitrofurantoin; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Thiazoles; Xanthine Oxidase | 1974 |
The role of cytochrome P-450 and P-448 in drug and steroid hydroxylations.
Topics: Age Factors; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Morphine Derivatives; Pentobarbital; Phenobarbital; Piperazines; Rats; Testosterone | 1973 |
Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Hydroxylation; Kinetics; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Structure-Activity Relationship | 1974 |
The stimulation of hydroxylation by carcinogenic and non-carcinogenic compounds.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Biphenyl Compounds; Carcinogens; In Vitro Techniques; Liver; Meprobamate; Methylcholanthrene; Mice; Microsomes; Mixed Function Oxygenases; Nikethamide; Phenobarbital; Polycyclic Compounds; Rats | 1966 |
Carcinogenesis and gene action. Franz Bielschowsky Memorial Lecture.
Topics: Animals; Azo Compounds; Carcinogens; Dactinomycin; DNA; Enzyme Induction; Genes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Molecular Biology; Neoplasms; Neoplasms, Experimental; Phenobarbital; Phenotype; Puromycin; Rats; RNA; RNA Nucleotidyltransferases | 1968 |
The biotransformation of 8-ethylthio-6-thiotheophylline sodium in vivo.
Topics: Amines; Animals; Carbon Tetrachloride; Chromatography, Thin Layer; Dactinomycin; Depression, Chemical; Hypnotics and Sedatives; Male; Methylcholanthrene; Oils; Phenobarbital; Proadifen; Rats; Sleep; Stimulation, Chemical; Theophylline; Time Factors | 1968 |
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.
Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time | 1968 |
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dactinomycin; Enzyme Induction; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Spectrophotometry; Stimulation, Chemical | 1973 |
Effect of inducers on the metabolism and excretion of disodium cromoglycate in rats.
Topics: Animals; Bile; Cromolyn Sodium; Enzyme Induction; Methylcholanthrene; Phenobarbital; Rats; Tritium | 1972 |
Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Polychlorinated Biphenyls; Rats; Sodium Dodecyl Sulfate | 1973 |
Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase.
Topics: Ammonium Sulfate; Animals; Bilirubin; Chemical Precipitation; Chloramphenicol; Cycloheximide; Deoxycholic Acid; Enzyme Activation; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Naphthols; Nitrophenols; Phenobarbital; Rats; Structure-Activity Relationship; Surface-Active Agents; Trypsin | 1973 |
Enhancement of microsomal drug hydroxylation and glucuronidation in rat liver by phenobarbital and 3-methylcholanthrene in combination.
Topics: Animals; Anisoles; Benzopyrenes; Cetylpyridinium; Coumarins; Culture Media; Digitonin; Drug Synergism; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrophenols; Oxygenases; Phenobarbital; Rats; Stimulation, Chemical; Trypsin | 1974 |
A comparative study on drug hydroxylation and glucuronidation in liver microsomes of phenobarbital and 3-methylcholanthrene treated rats.
Topics: Animals; Anisoles; Cetylpyridinium; Coumarins; Cytochrome P-450 Enzyme System; Digitonin; Drug Combinations; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Nitrophenols; Oxidoreductases; Phenobarbital; Phospholipases; Proteins; Stimulation, Chemical; Thiocyanates; Trypsin | 1974 |
Modification of the response of rats to lethal levels of ozone by enzyme-inducing agents.
Topics: Allylisopropylacetamide; Aminobenzoates; Animals; Enzyme Induction; Male; Methylcholanthrene; Oxidoreductases; Ozone; Phenobarbital; Phenothiazines; Polychlorinated Biphenyls; Rats; Time Factors | 1974 |
UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Cell Membrane; Enzyme Activation; Esters; Glucuronates; Glucuronosyltransferase; Hexosyltransferases; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Microsomes, Liver; Naphthols; Organ Size; Perfusion; Phenobarbital; Proteins; Rats; Sulfuric Acids; Surface-Active Agents; Uridine Diphosphate Sugars | 1974 |
[Stimulation of several microsomal drug oxidations by phenobarbital, methylcholanthrene and chlorophenothane, single and in combinations].
Topics: Aniline Compounds; Animals; DDT; Drug Synergism; Female; Liver; Methylcholanthrene; Microsomes; Nitrobenzenes; Organ Size; Phenobarbital; Rats; Stimulation, Chemical | 1967 |
[Spectral properties of cytochrome P450 following induction with phenobarbital, benzopyrene and methylcholanthrene].
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Enzyme Induction; Hexobarbital; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Spectrophotometry; Stimulation, Chemical | 1968 |
Proceedings: UDP-glucuronyltransferase in perfused rat liver and in microsomes: influence of phenobarbital and 3-methylcholanthrene.
Topics: Animals; Bile; Glucuronates; Glucuronosyltransferase; Hexosyltransferases; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Naphthols; Organ Size; Perfusion; Phenobarbital; Proteins; Rats | 1974 |
Proceedings: The effect of cysteamine on the microsomal drug metabolism system.
Topics: Acetanilides; Animals; Biotransformation; Cysteamine; Dealkylation; In Vitro Techniques; Kinetics; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Peroxidases; Pharmaceutical Preparations; Phenobarbital | 1974 |
Carcinogens 3,4-benzpyrene and 3-methylcholanthrene: induction of mitochondrial oxidative enzymes.
Topics: Animals; Benzopyrenes; Dactinomycin; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Enzyme Induction; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hydroxybutyrate Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Methylcholanthrene; Mitochondria, Liver; Phenobarbital; Rats; Stimulation, Chemical; Succinate Dehydrogenase; Tetrazolium Salts; Triiodothyronine | 1968 |
Factors affecting the toxicity and metabolism of OMPA (octamethylpyrophosphoramide) in rats.
Topics: Age Factors; Animals; Butylene Glycols; Chlorpromazine; Cholinesterase Inhibitors; Cholinesterases; Diphosphates; Ethionine; Female; Glutethimide; Insecticides; Liver; Male; Meprobamate; Methylcholanthrene; Microsomes; Pentobarbital; Phenobarbital; Proadifen; Rats | 1967 |
Ligand interactions with hemoprotein P-450. II. Influence of phenobarbital and methylcholanthrene induction processes on P-450 spectra.
Topics: Amines; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Heme; Imidazoles; Liver; Male; Methylcholanthrene; Microsomes; Myoglobin; Phenobarbital; Protein Biosynthesis; Rabbits; Spectrophotometry; Stimulation, Chemical | 1969 |
[Changes in the phospholipid content of liver microsomes following various pretreatments of rats and guinea pigs].
Topics: Animals; Cytochromes; Diabetes Mellitus, Experimental; Guinea Pigs; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Rats; Scurvy; Spectrophotometry; Sphingomyelins; Starvation | 1970 |
Effect of drugs on hepatic drug metabolism in the fetus and newborn.
Topics: Animals; Animals, Newborn; Coumarins; Female; Fetus; Glucose-6-Phosphatase; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sleep; Transferases | 1970 |
Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat.
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Coumarins; Drug Antagonism; Enzymes; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Phosphoric Monoester Hydrolases; Rats; Toluene | 1970 |
Electron paramagnetic resonance study of the high- and low-spin forms of cytochrome P-450 in liver and in liver microsomes from a methylcholanthrene-treated rabbit.
Topics: Adrenal Glands; Animals; Cattle; Cytochromes; Electron Spin Resonance Spectroscopy; Iron; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria; Phenobarbital; Pseudomonas; Rabbits; Rats | 1970 |
A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide.
Topics: Aging; Animals; Cell Fractionation; Centrifugation; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Enzyme Induction; Ethers, Cyclic; Female; Glucose-6-Phosphatase; Glycols; Guinea Pigs; Hydro-Lyases; Kidney; Liver; Macaca; Male; Membranes; Methods; Methylcholanthrene; Microsomes; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Potassium Chloride; Rabbits; Rats; Sex Factors; Solubility; Species Specificity; Stimulation, Chemical; Styrenes; Sucrose; Tritium; Water | 1971 |
Benzypyrene hydroxylase activity in isolated parenchymal and nonparenchymal cells of rat liver.
Topics: Animals; Benzopyrenes; Enzyme Induction; Flavonoids; Hyaluronoglucosaminidase; Male; Methylcholanthrene; Microbial Collagenase; Microscopy, Fluorescence; Microsomes, Liver; Mixed Function Oxygenases; Mononuclear Phagocyte System; Perfusion; Phenobarbital; Pronase; Rats | 1972 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochrome c Group; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; Nitriles; Organ Size; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Spectrophotometry | 1972 |
Interaction of modifiers of hepatic microsomal drug metabolism and the inhalation toxicity of 1,1-dichloroethylene.
Topics: Aerosols; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chlorine; Chromatography, Gas; Drug Interactions; Ethylamines; Glucose-6-Phosphatase; Hydrocarbons, Halogenated; Lung; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Proadifen; Rats; Time Factors | 1972 |
The conversion of hepatic cytochrome P-450 to P-420 in normal and phenobarbital- and 3-methylcholanthrene-treated animals.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Ligands; Mercury; Methylcholanthrene; Microsomes, Liver; Organometallic Compounds; Phenobarbital; Rabbits; Rats; Spectrum Analysis | 1972 |
Carbon tetrachloride activation in liver microsomes from rats induced with 3-methylcholantrene.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucose-6-Phosphatase; In Vitro Techniques; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats | 1973 |
Genetic regulation of aryl hydrocarbon hydroxylase induction. V. Specific changes in spin state of cytochrome P 450 from genetically responsive animals.
Topics: Acetone; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Enzyme Induction; Female; Flavonoids; Kidney; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Molecular Biology; Naphthalenes; Phenobarbital; Protein Binding; Rabbits; Rats; Surface-Active Agents; Temperature | 1973 |
A low-temperature EPR study of partially purified, soluble ferric cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Animals; Benzopyrenes; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochromes; Electron Spin Resonance Spectroscopy; Guanidines; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1973 |
Effect of phenobarbital and 3-methylcholanthrene pretreatment on the hepatotoxicity of 1,1,1-trichloroethane and 1,1,2-trichloroethane.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Ethane; Glucose-6-Phosphatase; Hydrocarbons, Chlorinated; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Time Factors | 1973 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinoma, Hepatocellular; Cell Line; Cricetinae; Culture Media; Enzyme Induction; Fetus; HeLa Cells; Humans; Isoproterenol; Liver; Liver Neoplasms; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Tryptamines | 1973 |
Enhancement of the hepatotoxicity of trichloroethylene by inducers of drug metabolism.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Drug Synergism; Glucose-6-Phosphatase; Liver; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Rats; Time Factors; Trichloroethylene | 1974 |
The preparation of microsomal fractions of rodent respiratory tract and their characterization.
Topics: Animals; Benzopyrenes; Benzphetamine; Biphenyl Compounds; Cell Fractionation; Centrifugation; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport Complex IV; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NAD; Oxidation-Reduction; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
Role of cytochrome b5 in hydroxylation by a reconstituted cytochrome P-450-containing system.
Topics: Animals; Benzopyrenes; Chromatography, DEAE-Cellulose; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Kinetics; Lipid Metabolism; Macromolecular Substances; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Spectrophotometry; Time Factors; Tritium | 1974 |
Effect of a catatoxic steroid pregnenolone-16alpha-carbonitrile, on rat liver microsomal subfractions.
Topics: Adenosine Triphosphatases; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Cycloheximide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dose-Response Relationship, Drug; Female; Glucose-6-Phosphatase; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nucleosides; Phenobarbital; Phospholipids; Phosphoric Monoester Hydrolases; Pregnenolone Carbonitrile; Proteins; Rats | 1974 |
Studies on the mechanism of action of mammalian hepatic azoreductase. II. The effects of phenobarbital and 3-methylcholanthrene on carbon monoxide sensitive and insensitive azoreductase activities.
Topics: Animals; Azo Compounds; Carbon Monoxide; Cytochromes; Female; Lipase; Liver; Methylcholanthrene; Microsomes; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats; Tetrazolium Salts | 1967 |
Hepatic microsomes and drug oxidation.
Topics: Animals; Cytochromes; Endoplasmic Reticulum; Insecticides; Liver; Maryland; Methylcholanthrene; Molecular Biology; NADP; National Library of Medicine (U.S.); Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; RNA, Messenger; Smoking; Steroids; Testosterone; United States | 1968 |
The effect of diphenyl-piperazine compounds and other agents on diphenylhydantoin, zoxazolamine and hexobarbital metabolism.
Topics: Animals; Benzopyrenes; Cyclizine; DDT; Diphenhydramine; Endoplasmic Reticulum; Hexobarbital; Humans; Hydroxyzine; Liver; Male; Meclizine; Methylcholanthrene; Mice; Microscopy, Electron; Phenethylamines; Phenobarbital; Phenytoin; Piperazines; Trifluoperazine; Zoxazolamine | 1968 |
Enhanced glucuronide formation in different tissues following drug administration.
Topics: Amino Alcohols; Animals; Benzopyrenes; Biotransformation; Cecum; Colon; Digestive System; Duodenum; Gastric Mucosa; Glucuronates; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intravenous; Kidney; Liver; Male; Methylcholanthrene; Organ Specificity; Phenobarbital; Quinolines; Rats; Salicylates; Stimulation, Chemical; Time Factors | 1968 |
Biliary flow after microsomal enzyme induction.
Topics: Animals; Benzopyrenes; Bile; Chlordan; Enzyme Induction; Liver; Methylcholanthrene; Microsomes; Nikethamide; Organ Size; Phenobarbital; Phenylbutazone; Piperazines; Rats; Zoxazolamine | 1969 |
Studies on the mechanism of nitro reduction by rat liver.
Topics: Aminobenzoates; Animals; Female; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Oxidoreductases; Oxygen; Phenobarbital; Rats | 1969 |
Influence of microsomal enzyme inducers on the reactivity of the isolated guinea pig seminal vesicle to angiotensin and tyramine.
Topics: Angiotensin II; Animals; Aspirin; Dactinomycin; DDT; Drug Antagonism; Enzyme Induction; Glutethimide; Guinea Pigs; Male; Meprobamate; Methylcholanthrene; Microsomes; Phenobarbital; Piperazines; Proadifen; Protein Biosynthesis; Seminal Vesicles; Sulfanilamides; Tyramine | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Ethanol metabolism in rats after microsomal metabolizing enzyme induction.
Topics: Animals; Chlordan; Enzyme Induction; Ethanol; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Piperazines; Rats; Stimulation, Chemical; Zoxazolamine | 1969 |
Different effect of aflatoxin on the induction of tryptophan oxygenase and of microsomal drug-hydroxylase system.
Topics: Aflatoxins; Animals; Cytochromes; Enzyme Induction; Female; Hexobarbital; Hydrocortisone; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rats; Tryptophan Oxygenase; Tyrosine Transaminase; Zoxazolamine | 1970 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Comparative N-demethylation of antihistaminic agents possessing dimethylaminoalkyl group by liver preparations from four animal species.
Topics: Age Factors; Animals; Castration; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Histamine H1 Antagonists; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Proadifen; Rabbits; Rats; Sex Factors; Species Specificity; Testosterone | 1971 |
Plasma disappearance and biliary excretion of sulfobromophthalein and phenol-3,6-dibromphthalein disulfonate after microsomal enzyme induction.
Topics: Animals; Benzopyrenes; Bile; Bromine; Chlordan; Enzyme Induction; Male; Methylcholanthrene; Microsomes; Nikethamide; Phenobarbital; Phenolphthaleins; Phenylbutazone; Piperazines; Rats; Rheology; Sodium; Sulfobromophthalein | 1970 |
Enzymatic reduction of niridazole by rat liver microsomes.
Topics: Aerobiosis; Animals; Anthelmintics; Carbon Monoxide; Chemical Precipitation; Chromatography, Gas; Cytochromes; Guinea Pigs; Hydroxylamines; Imidazoles; Ketones; Lipase; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Nitro Compounds; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygen; Pancreatic Juice; Phenobarbital; Quaternary Ammonium Compounds; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfates; Tetrazolium Salts; Thiazoles | 1971 |
Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes.
Topics: Acetamides; Allyl Compounds; Animals; Bacillus subtilis; Carbon Monoxide; Cell Fractionation; Chick Embryo; Cytochromes; Depression, Chemical; Detergents; Etiocholanolone; Female; Flavins; Heme; Ketosteroids; Liver; Methods; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Nitrogen; Oxidoreductases; Peptide Hydrolases; Phenobarbital; Pregnanes; Rats; Solubility; Spectrophotometry; Stimulation, Chemical | 1971 |
Effect of caffeine on hepatic microsomal cytochrome P-450.
Topics: Acetanilides; Adrenalectomy; Animals; Anisoles; Caffeine; Cytochromes; Enzyme Induction; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitriles; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry; Sulfites; Time Factors | 1970 |
Some effects of 3-methylcholanthrene on uridine diphosphate glucuronyltransferase in the rat and guinea pig.
Topics: Animals; Dactinomycin; Enzyme Induction; Ethionine; Glucuronates; Glucuronosyltransferase; Guinea Pigs; Hexosyltransferases; Hydrocarbons; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Magnesium; Male; Methylcholanthrene; Microsomes, Liver; Nikethamide; Nucleoside Diphosphate Sugars; Phenobarbital; Phenols; Piperazines; Protein Biosynthesis; Rats; Time Factors; Uracil Nucleotides | 1971 |
The interaction of a fluorescent probe with rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Oxidoreductases; Phenobarbital; Rats; Sulfites; Sulfonic Acids; Warfarin | 1970 |
Chemical and enzymatic composition of microsomal subfractions from rat liver after treatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cholesterol; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Proteins; Rats; RNA; Spectrum Analysis; Tritium | 1970 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.
Topics: Animals; Benzopyrenes; Carbon Isotopes; Catalysis; Cytochromes; Dealkylation; Enzyme Induction; Hydroxylation; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Piperazines; Rats; Testosterone | 1972 |
Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase in drug oxidation.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Dealkylation; Immune Sera; Immunodiffusion; Immunoglobulins; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Phenobarbital; Rabbits; Rats | 1971 |
Enzymatic dechlorination. Dechlorination of chloroethanes and propanes in vitro.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlorine; Enzyme Induction; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Radioisotopes; Rats; Ultracentrifugation | 1971 |
A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro.
Topics: Animals; Female; Glucosephosphate Dehydrogenase; Glucosephosphates; Histamine H1 Antagonists; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Piperazines; Proteins; Rats; Rats, Inbred Strains; Time Factors; Tritium | 1972 |
Differential acute effects of phenobarbital and 3-methylcholanthrene pretreatment on CCl 4 -induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cytochrome c Group; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proteins; Rats; Time Factors | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.
Topics: Ammonium Sulfate; Animals; Benzopyrenes; Bile Acids and Salts; Catalysis; Chemical Precipitation; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Oxidoreductases; Phenobarbital; Phosphatidylcholines; Rats; Surface-Active Agents | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VI. Different substrate specificities of the cytochrome P450 fractions from control and phenobarbital-treated rats.
Topics: Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Dealkylation; Dose-Response Relationship, Drug; Flavonoids; Hemeproteins; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Pentobarbital; Phenobarbital; Piperazines; Proadifen; Rats; Structure-Activity Relationship; Testosterone | 1973 |
A sensitive radiometric assay of aminopyrine N-demethylation.
Topics: Acetamides; Aminopyrine N-Demethylase; Animals; Carbon Isotopes; Chick Embryo; Colorimetry; Cytochrome P-450 Enzyme System; Dealkylation; Fetus; Formaldehyde; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kidney; Kinetics; Liver; Lung; Male; Methods; Methylcholanthrene; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Proteins; Rats | 1973 |
Comparison of the O-dealkylation of 7-ethoxycoumarin and the hydroxylation of benzo(a)pyrene in human placenta. Effect of cigarette smoking.
Topics: Animals; Benzopyrenes; Coumarins; Dealkylation; Enzyme Induction; Ethyl Ethers; Female; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Placenta; Pregnancy; Rats; Smoking; Time Factors | 1974 |
Effect of basic cupric acetate on biochemical changes in the liver of the rat fed carcinogenic aminoazo dye. III. Effect of copper compared with some other metals, phenobarbital and 3-methylcholanthrene on the metabolism of 4-dimethylaminoazobenzene.
Topics: Animals; Azo Compounds; Carcinogens; Coloring Agents; Copper; Dimethylamines; Liver; Methylcholanthrene; Phenobarbital; Rats | 1974 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine | 1974 |
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Enzyme Induction; Liver; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium | 1974 |
Metabolism of acetanilide with hepatic microsomes and reconstituted cytochrome monoxygenase systems.
Topics: Acetanilides; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cytochromes; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Solubility; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1974 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; Enzymes; Glucuronates; Glutathione; Half-Life; Intestinal Absorption; Kidney; Kinetics; Liver Diseases; Metabolism; Methylcholanthrene; Mice; Models, Theoretical; Necrosis; Phenobarbital; Proadifen; Rats; Regional Blood Flow; Sulfates; Toxicology | 1974 |
The effects of 3-methylcholanthrene and phenobarbital induction on the structure of the rat liver endoplasmic reticulum.
Topics: Animals; Butylated Hydroxytoluene; Cytochromes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Iodine Radioisotopes; Liver; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Peroxidases; Phenobarbital; Protein Binding; Proteins; Rats; Ribosomes; Sodium Dodecyl Sulfate; Trypsin | 1974 |
Methylcholanthrene-induced adenocarcinoma of the prostate in rats.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Male; Methylcholanthrene; Neoplasms, Experimental; Phenobarbital; Prostatic Neoplasms; Rats | 1974 |
Phospholipid synthesis in rat liver endoplasmic reticulum after the administration of phenobarbitone and 20-methylcholanthrene.
Topics: Animals; Carbon Radioisotopes; Endoplasmic Reticulum; Glycerol; In Vitro Techniques; Liver; Methionine; Methylcholanthrene; Methyltransferases; Phenobarbital; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Radioisotopes; Rats | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Glutathione; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes, Liver; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Stimulation, Chemical | 1974 |
Studies on the lipid composition of the rat liver endoplasmic reticulum after induction with phenobarbitone and 20-methylcholanthrene.
Topics: Animals; Arachidonic Acids; Cholesterol; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Fatty Acids; Injections, Intraperitoneal; Linolenic Acids; Lipids; Liver; Male; Methylcholanthrene; Oleic Acids; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats | 1974 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Mice; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Stimulation, Chemical; Tritium | 1974 |
Hepatic microsomal mixed function oxygenase: enzyme multiplicity for the metabolism of carcinogens to DNA-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carcinogens; Cattle; DNA; Enzyme Activation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1974 |
Metabolic transformation of colchicine, II. The metabolism of colchicine by mammalian liver microsomes.
Topics: Aging; Animals; Colchicine; Cricetinae; Glucuronates; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Species Specificity | 1974 |
Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography.
Topics: Animals; Benzopyrenes; Biotransformation; Carcinogens; Chromatography; Cytochromes; Enzyme Induction; Hydro-Lyases; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxides; Phenobarbital; Phenols; Quinones; Rats | 1974 |
Magnetic circular dichroism studies XXXV. A comparison of cytochromes P-450 and P-448.
Topics: Circular Dichroism; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Conformation | 1974 |
Studies on the role of the liver in the metabolism of parathyroid hormone. I. Effects of partial hepatectomy and incubation of the hormone with tissue homogenates.
Topics: Adrenal Glands; Adrenalectomy; Animals; Antigens; Aprotinin; Calcium; Culture Techniques; Female; Hemorrhage; Hepatectomy; Hydrocortisone; Kidney; Liver; Male; Methylcholanthrene; Nephrectomy; Parathyroid Glands; Parathyroid Hormone; Phenobarbital; Phosphorus; Proadifen; Radioimmunoassay; Rats; Spleen | 1972 |
Comparative studies on aniline hydroxylation and p-nitrotoluene hydroxylation by the liver.
Topics: Acetamides; Acetone; Aniline Compounds; Animals; Biotransformation; Cricetinae; Depression, Chemical; Guinea Pigs; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mice; Phenobarbital; Pyridines; Rabbits; Rats; Sex Factors; Stimulation, Chemical; Toluene | 1972 |
Comparative studies on hepatic N- and O-demethylation.
Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide | 1972 |
Induction of mutations in DNA-repair deficient bacteria by a liver microsomal metabolite of aflatoxin B1.
Topics: Aflatoxins; Animals; Benzopyrenes; Cysteine; Dimercaprol; DNA Repair; DNA, Bacterial; Escherichia coli; Liver; Male; Methionine; Methylcholanthrene; Microsomes, Liver; Mutation; Oxidoreductases; Phenobarbital; Rats; Salmonella typhimurium; Ultraviolet Rays | 1973 |
Dependence of specific metabolism of benzo(a)pyrene on the inducer of hydroxylase activity.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Enzyme Induction; Hydro-Lyases; Hydrocarbons; Liver; Lung; Male; Methylcholanthrene; Mutagens; Oxidoreductases; Phenobarbital; Rats; Salmonella typhimurium | 1974 |
Induction of drug metabolism. VI. Effects of phenobarbital and 3-methylcholanthrene administration on N-demethylating enzyme systems of rough and smooth hepatic microsomes.
Topics: Animals; Blood Proteins; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Morphinans; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Time Factors | 1973 |
Differences in microsomal enzyme induction between Sprague-Dawley and Long-Evans rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Antipyrine; Brain Chemistry; DDT; Enzyme Induction; Eucalyptus; Female; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenols; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; Sleep | 1972 |
Evidence for extrahepatic metabolism of parathion.
Topics: Animals; Brain; Liver; Lung; Methylcholanthrene; Microsomes; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Phosphorus Isotopes; Rabbits; Rats; Sulfur Isotopes | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. IV. Hydroxylation of aniline.
Topics: Acetone; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Carbon Isotopes; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Activation; Hydroxylation; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Spectrophotometry | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. V. Competition between cytochromes P-450 and P-448 for reductase in 3,4-benzpyrene hydroxylation.
Topics: Animals; Benzopyrenes; Computers; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Activation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1972 |
Cytochrome P-450 as a microsomal peroxidase in steroid hydroperoxide reduction.
Topics: Adrenal Glands; Aniline Compounds; Animals; Cattle; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; Hydroxylation; Hydroxyprogesterones; Kinetics; Ligands; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidation-Reduction; Peroxidases; Peroxides; Phenobarbital; Pregnenolone; Progesterone; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Steroids | 1972 |
Effect of phenobarbital and 3-methylcholanthrene administration on the in vitro enhancement of microsomal aromatic hydroxylation.
Topics: Acetanilides; Acetone; Aniline Compounds; Animals; Benzphetamine; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Protein Binding; Pyridines; Rats; Spectrophotometry; Time Factors | 1972 |
Differences in P-450 cytochromes from livers of rats treated with phenobarbital and with 3-methylcholanthrene.
Topics: Ammonium Sulfate; Animals; Chromatography, DEAE-Cellulose; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Drug Synergism; Glycerol; Hemeproteins; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Subcellular Fractions; Surface-Active Agents | 1973 |
Increased antitumour activity of chlorambucil following pretreatment with inducers of drug-metabolizing enzymes.
Topics: Animals; Benz(a)Anthracenes; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Enzyme Induction; In Vitro Techniques; Methylcholanthrene; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms, Experimental; Phenobarbital; Premedication; Rats; RNA, Neoplasm; Sarcoma, Yoshida; Transplantation, Homologous | 1973 |
Studies of the mechanisms of metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) by rabbit liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Phosphorus Isotopes; Rabbits | 1973 |
Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis.
Topics: Animals; Autoradiography; Bromine; Bronchial Diseases; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Epithelial Cells; Epithelium; Hydrocarbons, Halogenated; Kidney Diseases; Lung Diseases; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats | 1973 |
Presence and induction of epoxide hydrase in cultured human leukocytes.
Topics: Cells, Cultured; Enzyme Induction; Ethers, Cyclic; Humans; Hydro-Lyases; Hydrolases; Kinetics; Leukocytes; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Tritium | 1973 |
Effects of phenobarbital and 3-methylcholanthrene on amino acid incorporation into rat liver chromosomal proteins.
Topics: Amino Acids; Animals; Carbon Isotopes; Chromatin; Chromosomes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Histones; In Vitro Techniques; Kinetics; Leucine; Liver; Male; Methylcholanthrene; Mitosis; Phenobarbital; Proteins; Rats; Time Factors; Tritium | 1973 |
Existence and separation of three forms of cytochrome P-450 from rat liver microsomes.
Topics: Amines; Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Deoxycholic Acid; Enzyme Induction; Ethanol; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Solubility; Spectrophotometry; Subtilisins | 1973 |
Further observation on the effects of 3-methylcholanthrene and phenobarbital on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cell Survival; Chemical and Drug Induced Liver Injury; Lipid Metabolism; Liver; Male; Methylcholanthrene; Phenobarbital; Polyribosomes; Rats; Time Factors; Triglycerides | 1973 |
Relative selectivity of some microsomal drug metabolizing enzyme inducers.
Topics: Acid-Base Equilibrium; Animals; Antigen-Antibody Reactions; Blood Protein Electrophoresis; Chlordan; Enzyme Induction; Glucosephosphate Dehydrogenase; Hematopoiesis; Malate Dehydrogenase; Methylcholanthrene; Microsomes, Liver; Mucoproteins; Phenobarbital; Rats | 1973 |
Regulation of hydroxylation of 5 alpha-androstane-3 beta, 17 beta-diol in liver microsomes from male and female rats.
Topics: Androstanes; Animals; Carbon Isotopes; Carbon Monoxide; Castration; Chromatography, Gas; Chromatography, Gel; Chromatography, Thin Layer; Dihydrotestosterone; Estradiol; Female; Hydroxylation; Hydroxysteroids; Male; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone; Rats; Sex Factors; Testis; Testosterone; Time Factors | 1973 |
Acute interaction of drugs. I. The effect of volatile anesthetics on the kinetics of aniline hydroxylase and aminopyrine demethylase in rat hepatic microsomes.
Topics: Aminopyrine N-Demethylase; Anesthetics; Aniline Compounds; Animals; Chloroform; Enzyme Induction; Ethyl Ethers; Halothane; In Vitro Techniques; Kinetics; Male; Methoxyflurane; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats | 1973 |
Species differences in induction and inhibition of liver isocarboxazid hydrolase.
Topics: Aging; Animals; Animals, Newborn; Enzyme Induction; Female; Guinea Pigs; Hydrolases; In Vitro Techniques; Isocarboxazid; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Pregnancy; Proadifen; Rabbits; Rats; Species Specificity | 1973 |
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Proadifen; Protein Binding; Pyrazoles; Rats; Sex Factors; Statistics as Topic | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Kidney; Lethal Dose 50; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Time Factors; Tritium | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Drug Antagonism; Half-Life; Hydrocarbons, Brominated; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Necrosis; Phenobarbital; Proadifen; Rats; Time Factors | 1973 |
Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide in liver microsomes of rabbits treated with phenobarbital or 3-methylcholanthrene.
Topics: Acetophenones; Anilides; Animals; Carbon Monoxide; Chlorine; Drug Storage; Female; Hydroxylation; Hypoxia; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pressure; Propionates; Rabbits; Time Factors | 1973 |
Preferential induction of aryl hydroxylase activity in rat liver nuclear envelope by 3-methylcholanthrene.
Topics: Animals; Benzopyrenes; Cell Nucleus; Centrifugation, Density Gradient; Enzyme Induction; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1973 |
Metabolism of methoxyflurane: release of inorganic fluoride in human and rat hepatic microsomes.
Topics: Animals; Biotransformation; Chlorine; Enzyme Induction; Fluorides; Formaldehyde; Humans; Hydrogen-Ion Concentration; Male; Methoxyflurane; Methylcholanthrene; Microsomes, Liver; Nitrous Oxide; Phenobarbital; Rats; Tetracycline | 1973 |
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Paralysis; Phenobarbital; Proadifen; Respiration; Sleep; Time Factors; Zoxazolamine | 1973 |
Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide by rabbits and rabbit liver microsomes.
Topics: Acrylates; Anilides; Animals; Benzene Derivatives; Chlorine; Chromatography, Thin Layer; Ethanol; Glycolates; Hydroxylation; In Vitro Techniques; Isomerism; Lactates; Magnetic Resonance Spectroscopy; Mandelic Acids; Methylcholanthrene; Microsomes, Liver; Optical Rotation; Optical Rotatory Dispersion; Phenobarbital; Propionates; Rabbits; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism | 1973 |
Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide in liver microsomes of rabbits treated weith phenobarbital or 3-methylcholanthrene.
Topics: Acetanilides; Acetophenones; Anilides; Animals; Carbon Monoxide; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Oxygen; Phenobarbital; Pressure; Propionates; Rabbits; Time Factors; Tissue Preservation | 1973 |
Enzymatic studies on the metabolism of the tetrahydrofurfuryl mercaptan moiety of thiamine tetrahydrofurfuryl disulfide. IV. Induction of microsomal S-transmethylase, and sulfide and sulfoxide oxygenases in the drug-treated rat.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Disulfides; Enzyme Induction; Female; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Phenobarbital; Rats; Sulfhydryl Compounds; Sulfides; Sulfoxides; Thiamine | 1973 |
Expression of aryl hydrocarbon hydroxylase induction in mouse tissues in vivo and in organ culture.
Topics: Animals; Enzyme Induction; Female; Fetus; Flavonoids; Gestational Age; Kinetics; Liver; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Microsomes; Mixed Function Oxygenases; Organ Culture Techniques; Phenobarbital; Pregnancy; Species Specificity; Time Factors | 1973 |
Genetic expression of the induction of epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse by phenobarbital or 3-methylcholanthrene.
Topics: Age Factors; Animals; Crosses, Genetic; Enzyme Induction; Ethers, Cyclic; Hydro-Lyases; Liver; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NZB; Mice, Inbred Strains; Mixed Function Oxygenases; Molecular Biology; Phenobarbital; Time Factors | 1973 |
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors | 1973 |
Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics.
Topics: Age Factors; Androstanes; Animals; Carbon Monoxide; Carbon Radioisotopes; Castration; Estradiol; Female; Hydroxysteroids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Sex Factors; Steroid Hydroxylases; Sulfuric Acids; Testosterone | 1974 |
The role of testosterone in the regulation of oxidative drug metabolism in normal and irradiated animals.
Topics: Aminopyrine N-Demethylase; Animals; Biphenyl Compounds; Cobalt Radioisotopes; Endoplasmic Reticulum; Enzyme Induction; Female; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Phenobarbital; Radiation Effects; Rats; Sex Factors; Testis; Testosterone; Time Factors | 1974 |
Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chemical Phenomena; Chemistry; Coenzymes; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Ligands; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pyridines; Rats; Spectrophotometry, Ultraviolet | 1974 |
The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Heme; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Spleen; Time Factors | 1974 |
Influence of sex hormones on vitamin K deficiency and epoxidation of vitamin K in the rat.
Topics: Animals; Carbon Radioisotopes; Castration; DDT; Estradiol; Ethers, Cyclic; Female; Gonadal Steroid Hormones; Hydrolases; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Progesterone; Prothrombin; Rats; Sex Factors; Testosterone; Time Factors; Vitamin K 1; Vitamin K Deficiency | 1974 |
Strain differences in the induction of soluble and microsomal enzymes by phenobarbital and 3-methylcholanthrene.
Topics: Aldehyde Oxidoreductases; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Solubility; Species Specificity; Spectrophotometry; Time Factors; Ultracentrifugation | 1974 |
Enhancement of D-glucuronolactone and acetaldehyde dehydrogenase activities in the rat liver by inducers of drug metabolism.
Topics: Acetaldehyde; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; DDT; Enzyme Induction; Germ-Free Life; Hydrogen-Ion Concentration; Lactones; Liver; Male; Methylcholanthrene; Oils; Organ Size; Phenobarbital; Proteins; Pyrazoles; Rats; Spironolactone | 1974 |
Effect of chronic treatment with phenobarbital or 3-methylcholanthrene on the male reproductive system in rats.
Topics: Animals; Body Weight; Carbon Radioisotopes; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes; Organ Size; Phenobarbital; Progesterone; Rats; Reproduction; Seminal Vesicles; Spectrophotometry; Steroid Hydroxylases; Testis; Testosterone | 1974 |
Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome P-450.
Topics: Alkanes; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrogen-Ion Concentration; In Vitro Techniques; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Solvents; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors | 1974 |
Stimulation of hepatic drug-metabolizing enzymes by DDT, polycyclic hydrocarbons or phenobarbital in adrenalectomized or castrated mice.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Castration; DDT; Dealkylation; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Methyltransferases; Mice; Mixed Function Oxygenases; Morphinans; Phenobarbital; Polycyclic Compounds; Proteins; Stimulation, Chemical; Testis | 1974 |
The lack of effects of pretreatment with phenobarbital and chlorpromazine on the acute toxicity of benzene in rats.
Topics: Aerosols; Animals; Benzene; Body Weight; Carbon Radioisotopes; Chlorpromazine; Chromatography, Gas; Female; Injections, Intraperitoneal; Liver; Lung; Methylcholanthrene; Microsomes; Microsomes, Liver; Organ Size; Phenobarbital; Phenols; Proteins; Rats | 1974 |
Metabolism of carcinogenic compounds. I. Effect of phenobarbital and methylcholanthrene on the activities of N-demethylation of carcinogenic compounds by liver microsomes of male and female rats.
Topics: Amines; Animals; Carcinogens; Female; Liver; Male; Methylation; Methylcholanthrene; Microsomes; Nitrosamines; p-Dimethylaminoazobenzene; Phenobarbital; Rats | 1967 |
The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states.
Topics: Adrenalectomy; Age Factors; Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Line; Cell Membrane; Chick Embryo; Cricetinae; Culture Techniques; Digestive System; Enzyme Induction; Female; Fetus; Haplorhini; Hydrocarbons; Hypophysectomy; Kidney; Liver; Lung; Male; Methylcholanthrene; Mice; Mixed Function Oxygenases; Organ Specificity; Phenobarbital; Placenta; Pregnancy; Rats; Species Specificity; Tritium | 1969 |
Bilirubin: a model for studies of drug metabolism in man.
Topics: Acetamides; Allyl Compounds; Amino Sugars; Amphibians; Animals; Anura; Bilirubin; Birds; Butyrophenones; Carbon Isotopes; Cats; Cell Nucleus; Chromatography, Gel; Cyclohexanes; DDT; Dieldrin; Fishes; Glucose; Goats; Guinea Pigs; Haplorhini; Humans; Iodobenzenes; Kinetics; Liver; Lysosomes; Mammals; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; Organ Specificity; Phenobarbital; Protein Binding; Protein Biosynthesis; Rats | 1971 |
Effects of phenobarbital, 3-methylcholanthrene, and hematin on the synthesis of protein components of rat liver microsomal membranes.
Topics: Animals; Carbon Isotopes; Cytochromes; Electrophoresis; Endoplasmic Reticulum; Heme; Leucine; Male; Membranes; Metabolism; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Sodium Dodecyl Sulfate; Solubility; Tritium | 1972 |
Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.
Topics: Ammonium Sulfate; Animals; Benzopyrenes; Benzphetamine; Calcium Phosphates; Carbon Monoxide; Chemical Precipitation; Cytochromes; Gels; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry | 1972 |
Conversion of naphthalene to trans-naphthalene dihydrodiol: evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes.
Topics: Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Chlorine; Ethers, Cyclic; Ethylmaleimide; Glutathione; Glycols; Guinea Pigs; Hydrolases; Male; Maleates; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Oxygenases; Phenanthrenes; Phenobarbital | 1972 |
Effect of enzyme induction on the metabolism of benzo(a)pyrene and 3'-methyl-4-monomethylaminoazobenzene in the pregnant and fetal rat.
Topics: Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Carcinogens; Cyanides; Cytochromes; Dealkylation; Enzyme Induction; Female; Fetus; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnancy; Rats; Spectrophotometry; Tritium | 1972 |
The effect of altering liver microsomal co-binding hemoprotein composition on pentobarbital-induced anesthesia.
Topics: Animals; Brain Chemistry; Carbon Isotopes; Cell Fractionation; Chromatography, Paper; Cytochromes; Hydroxylation; Male; Methods; Methylcholanthrene; Microsomes, Liver; Pentobarbital; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Sleep | 1972 |
Therapeutic efficacy of cyclophosphamide as a function of its metabolism.
Topics: Acetamides; Animals; Carcinoma 256, Walker; Cobalt; Cyclophosphamide; Cytochromes; Female; In Vitro Techniques; Kinetics; Leukocyte Count; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Rats; Sodium Chloride; Sulfides | 1972 |
A comparison of the in vitro metabolism of parathion in the lung and liver of the rabbit.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Liver; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Phosphorus Isotopes; Rabbits | 1972 |
Studies on metabolism of 3-deoxysteroids. X. Increased activity of 3-deoxyestrone hydroxylases in liver microsomes of rats pretreated with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Chromatography, Thin Layer; Estrone; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Stimulation, Chemical | 1972 |
Experiments aiming at demonstrating microsomal drug metabolism in the tumor tissue.
Topics: Aniline Compounds; Animals; Anisoles; Ethers; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microsomes; Neoplasm Transplantation; Neoplasms, Experimental; Phenobarbital; Phenols; Rats | 1972 |
Biliary excretion of 3-methylcholanthrene as controlled by its metabolism.
Topics: Animals; Benzopyrenes; Bile; Depression, Chemical; Enzyme Induction; Female; Half-Life; Injections, Intravenous; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Stimulation, Chemical; Time Factors; Tritium | 1972 |
Induction of liver microsomal drug metabolism and inhibition of microsomal ribonuclease activity by phenobarbital.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Dealkylation; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Induction; Hypophysectomy; Male; Methylcholanthrene; Microsomes, Liver; Nitro Compounds; Oxidoreductases, N-Demethylating; Phenobarbital; Pituitary Gland; Rats; Ribonucleases; Stimulation, Chemical | 1972 |
Acute toxicity and antiesterase action of O-ethyl-S,S-diphenyl phosphorodithioate (Hinosan).
Topics: Animals; Atropine; Benzene Derivatives; Brain; Cholinesterase Inhibitors; Cholinesterases; DDT; Drug Interactions; Drug Resistance; Drug Synergism; Female; Fungicides, Industrial; Injections, Intraperitoneal; Insecticides; Lethal Dose 50; Malathion; Male; Methylcholanthrene; Organothiophosphorus Compounds; Phenobarbital; Pralidoxime Compounds; Rats; Submandibular Gland; Testosterone; Time Factors | 1972 |
A comparative ultrastructural study on drug-induced proliferation of smooth-surfaced endoplasmic reticulum in hepatocytes.
Topics: Animals; Endoplasmic Reticulum; Female; Liver; Methylcholanthrene; Microscopy, Electron; Organoids; Phenobarbital; Pregnenolone; Rats; Spironolactone | 1971 |
Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis.
Topics: Allyl Compounds; Animals; Benzopyrenes; Cholestasis; DDT; Densitometry; Dieldrin; Dwarfism, Pituitary; Electrophoresis, Disc; Ethinyl Estradiol; Hypophysectomy; Indocyanine Green; Liver; Male; Methylcholanthrene; Phenobarbital; Protein Binding; Proteins; Rats; Sulfobromophthalein; Thyroid Hormones; Thyroidectomy | 1971 |
The effects of some stimulators (inducers) of hepatic microsomal drug-metabolizing enzyme activity on substrate-induced difference spectra in rat liver microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Carbon Isotopes; DDT; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Spectrophotometry | 1971 |
Kinetic differences in the microsomal metabolism of the isomers of hexobarbital.
Topics: Animals; Enzyme Induction; Hexobarbital; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rabbits; Rats; Stereoisomerism; Time Factors | 1971 |
A comparison of some properties of microsomal cytochrome P-450 from normal, methylcholanthrene-, and phenobarbital-treated rats.
Topics: 1-Propanol; Amines; Animals; Chemical Phenomena; Chemistry; Chlorides; Cycloheximide; Cytochromes; Fasting; Fatty Alcohols; Heme; Hydrogen-Ion Concentration; Kinetics; Male; Mathematics; Mercury; Methylcholanthrene; Microsomes, Liver; Nitriles; Oxidation-Reduction; Phenobarbital; Potassium; Protein Biosynthesis; Rats; Spectrophotometry; Sulfites; Thiocyanates; Triazoles | 1971 |
Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat tissues: differential inhibition and stimulation by benzoflavones and organic solvents.
Topics: 1-Propanol; Acetone; Alcohols; Animals; Benz(a)Anthracenes; Benzopyrenes; Cells, Cultured; Cricetinae; Dimethyl Sulfoxide; Embryo, Mammalian; Enzyme Induction; Ethanol; Flavonoids; In Vitro Techniques; Kidney; Lung; Male; Methanol; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Phenobarbital; Rats; Skin | 1971 |
Aminopyrine demethylase--multiplicity shown by dieldrin and DDT inhibition.
Topics: Aminopyrine; Animals; DDT; Dealkylation; Dieldrin; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Stimulation, Chemical | 1971 |
The enzymatic N-hydroxylation of an imine. A new cytochrome P-450-dependent reaction catalyzed by hepatic microsomal monooxygenases.
Topics: Acetophenones; Animals; Catalysis; Chromatography, Gas; Cytochromes; Enzyme Induction; Hydroxylation; Imines; Liver; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Oximes; Oxygen Consumption; Phenobarbital; Rats; Stimulation, Chemical | 1971 |
Effect of inducers of drug-metabolizing enzymes on diethylnitrosamine metabolism and toxicity.
Topics: Animals; DDT; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Rats; Toluene | 1971 |
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1971 |
Drug stimulation of putrescine and spermidine syntheses. Relationships to enhancement of ribonucleic acid synthesis.
Topics: Animals; Benzopyrenes; Carboxy-Lyases; Clofibrate; Cycloheximide; Heparin; Liver; Male; Methylcholanthrene; Ornithine; Phenobarbital; Polyamines; Putrescine; Rats; RNA; S-Adenosylmethionine; Spermidine; Stimulation, Chemical; Tritium; Uridine | 1971 |
Labeling in vivo of rat liver proteins by tritium-labeled dimethylnitrosamine. Effect of prior treatment with 3-methylcholanthrene, phenobarbitone, dimethylformamide, diethyl-formamide, aminoacetonitrile, ethionine and carbon tetrachloride.
Topics: Amides; Animals; Carbon Tetrachloride; Carcinogens; Dimethylformamide; Endoplasmic Reticulum; Ethionine; Female; Formamides; Liver; Liver Neoplasms; Male; Methylcholanthrene; Neoplasms, Experimental; Nitriles; Nitrosamines; Phenobarbital; Protein Biosynthesis; Rats; Tritium | 1971 |
Differences in soluble P-450 hemoproteins from livers of rats treated with phenobarbital and 3-methylcholanthrene.
Topics: Cytochromes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Solubility; Spectrum Analysis | 1971 |
The importance of cytochrome P-450 and P-448 in determining the specificity of the reconstituted liver microsomal hydroxylation system.
Topics: Animals; Cytochromes; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1971 |
Factors affecting the in vitro interaction of biphenyl with P-450 in the hamster.
Topics: Animals; Biphenyl Compounds; Cricetinae; Cytochromes; Drug Interactions; Hydrogen-Ion Concentration; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Spectrum Analysis | 1971 |
Chromatography of radioactive microsomal hemoproteins on diethylaminoethyl cellulose.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chromatography, DEAE-Cellulose; Cytochromes; Heme; Kinetics; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Solubility; Time Factors; Tritium | 1971 |
Interference of Beryllium with enzyme induction in rat liver.
Topics: Acetanilides; Aminopyrine; Animals; Beryllium; DNA; DNA Replication; Enzyme Induction; Hydrocortisone; Lethal Dose 50; Liver; Liver Regeneration; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Tryptophan; Tryptophan Oxygenase | 1971 |
Microsomal nucleic acid breakdown in livers of phenobarbital-treated rats.
Topics: Animals; Carbon Isotopes; Drug Tolerance; Enzyme Induction; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nucleic Acids; Orotic Acid; Phenobarbital; Rats; Rats, Inbred Strains; Ribonucleases; Ribosomes; RNA; Sleep; Spectrophotometry; Time Factors | 1971 |
Induction and repression of microsomal drug-metabolizing enzymes by polycyclic hydrocarbons and phenobarbital: theoretical models.
Topics: Allosteric Regulation; Animals; Benz(a)Anthracenes; Benzopyrenes; Chlordan; Enzyme Induction; Enzyme Repression; Ethionine; Fluorenes; Genes, Regulator; Hexobarbital; Meperidine; Methylcholanthrene; Microsomes, Liver; Models, Biological; Operon; Oxidoreductases; Phenobarbital; Rats; Zoxazolamine | 1971 |
Studies on the mechanism of tolerance to nicotine-induced elevations of urinary catecholamines.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Catechol O-Methyltransferase; Catecholamines; Catechols; Drug Tolerance; Enzyme Induction; Fluorometry; Heart; Hexobarbital; In Vitro Techniques; Liver; Male; Metabolism; Methylcholanthrene; Methyltransferases; Monoamine Oxidase; Myocardium; Nerve Endings; Nicotine; Norepinephrine; Oxidoreductases; Perfusion; Phenobarbital; Rats; S-Adenosylmethionine; Sleep; Time Factors; Tritium; Zoxazolamine | 1971 |
Modification of catecholamine content of male accessory sexual tissues of guinea pig after pretreatment with microsomal enzyme inducers.
Topics: Adrenal Glands; Animals; Brain; Castration; Catecholamines; Dactinomycin; DDT; Epinephrine; Guinea Pigs; Male; Methylcholanthrene; Norepinephrine; Pargyline; Phenobarbital; Proteins; Seminal Vesicles; Testis; Vas Deferens | 1971 |
Effects of inducers of liver microsomal enzymes on the composition of microsomal hemoprotein.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlordan; Cytochromes; Enzyme Induction; Heme; Hemeproteins; Hydroxylation; In Vitro Techniques; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Time Factors; Tritium | 1971 |
The effect of microsomal enzyme stimulants and depressants on amphetamine aggregation toxicity in mice.
Topics: Amphetamine; Animals; Benzopyrenes; Carbon Tetrachloride; Chlordan; Enzyme Repression; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Proadifen | 1969 |
Differences among the action of phenobarbital, methylcholanthrene and male sex hormone on microsomal drug-metabolizing enzyme systems of rat liver.
Topics: Animals; Castration; Dihydrolipoamide Dehydrogenase; Fasting; Female; Liver; Male; Methylcholanthrene; Methyltestosterone; Microsomes; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry | 1966 |
Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Blood Proteins; Brain; Brain Chemistry; Cytochromes; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Nitrobenzenes; Pentobarbital; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Triazoles; Zoxazolamine | 1967 |
Contrastic effects of ethionine and carbontetrachloride on ascorbic acid metabolism and on the activity of microsomal drug-metabolizing enzymes in rats.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Carbon Tetrachloride; Chlorobutanol; Ethionine; Female; Injections, Intraperitoneal; Kidney; Liver; Meprobamate; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Zoxazolamine | 1967 |
Effect of phenobarbital and methylcholanthrene treatment on drug-induced difference spectrum of liver microsomes.
Topics: Aniline Compounds; Animals; Cytochromes; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry | 1969 |
Differences in the oxidative metabolism of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Oxidoreductases; Pentobarbital; Phenobarbital; Proadifen; Rats; Sex Factors; Starvation; Thyroxine; Zoxazolamine | 1969 |
N-demethylation of p-(N1-methylhydrazion methyl)-N-isopropyl benzamide (procarbazine), a cytostatically active methylhydrazine derivative, in the intact rat and in the isolated perfused rat liver.
Topics: Animals; Benzoates; Carbon Dioxide; Carbon Isotopes; Hydrazines; Liver; Male; Methylation; Methylcholanthrene; Oxidation-Reduction; Perfusion; Phenobarbital; Proadifen; Rats | 1969 |
Factors affecting the metabolism and response to hexobarbital.
Topics: Age Factors; Animals; Body Weight; Breeding; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Sex Factors; Sleep; Species Specificity; Time Factors | 1969 |
Subfractionation of rat liver microsomes: effects of phenobarbital and 3-methyl cholanthrene.
Topics: Amides; Animals; Centrifugation, Zonal; Cytochromes; Densitometry; Enzyme Induction; Ethionine; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1969 |
Participation of the microsomal electron transport system involving cytochrome P-450 in 7alpha-hydroxylation of cholesterol.
Topics: Animals; Antibodies; Biliary Fistula; Carbon Isotopes; Carbon Monoxide; Cholesterol; Cytochromes; Electron Transport; Fasting; Hydrocortisone; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Proteins; Rabbits; Rats; Thyroxine | 1969 |
Induction of drug-metabolizing enzymes and cytochrome P-450.
Topics: Cycloheximide; Cytochromes; Endoplasmic Reticulum; Enzyme Induction; Liver; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Phenothiazines; Puromycin | 1969 |
Effect of drug administration on the activity of the hepatic microsomal ethanol oxidizing system.
Topics: Alcohol Oxidoreductases; Animals; Catalase; Ethanol; Female; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Proteins; Rats; Toluene; Triazoles | 1970 |
A simple radiometric assay for microsomal aryl hydroxylase activity.
Topics: Acetanilides; Administration, Oral; Animals; Carbon Isotopes; Carbon Monoxide; Enzyme Induction; Injections; Liver; Male; Methods; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Radiochemistry; Rats; Stimulation, Chemical; Sulfonamides; Time Factors; Tritium | 1970 |
Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes.
Topics: Alkylation; Aniline Compounds; Animals; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Stereoisomerism | 1970 |
[Influence of ascorbic acid on the induction of monooxygenase in liver microsomes].
Topics: Aminopyrine; Animals; Ascorbic Acid; Biotransformation; Cytochromes; Enzyme Induction; Female; Guinea Pigs; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Scurvy; Stimulation, Chemical | 1970 |
Effects of phenobarbital, phenylbutazone, 3,4-benzpyrene, or 3-methylcholanthrene on ethanol metabolism in the rat.
Topics: Acacia; Alcohol Oxidoreductases; Animals; Benzopyrans; Brain; Cell Membrane Permeability; Enzyme Induction; Ethanol; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylbutazone; Rats; Resins, Plant; Sleep; Time Factors; Water | 1970 |
Species differences in the induction of microsomal hemoproteins and 3,4-benzpyrene hydroxylase by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Benzopyrenes; Blood Proteins; Carbon Monoxide; Cytochromes; Enzyme Induction; Guinea Pigs; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Species Specificity; Spectrum Analysis | 1970 |
Substrate-induced spectral change of liver microsomes in phenobarbital and methylcholanthrene-treated male and female rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Chemical Phenomena; Chemistry; Female; Hexobarbital; Male; Meperidine; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Proteins; Rats; Spectrophotometry; Spectrum Analysis; Zoxazolamine | 1970 |
Further evidene on the nature of microsomal metabolism of procarbazine and related alkyhydrazines.
Topics: Animals; Benzoates; Carbon Monoxide; Cytochromes; Enzyme Induction; Hydrazines; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen; Oxidoreductases; Oxygen; Phenobarbital; Proadifen; Rats; Sheep; Swine; Trypsin | 1970 |
Mechanism of 3-methylcholanthrene-induced inhibition of dimethylnitrosamine demethylase in rat liver.
Topics: Animals; Dactinomycin; Female; Kinetics; Liver; Male; Methylcholanthrene; Methyltestosterone; Microsomes, Liver; Nitrosamines; Oxidoreductases; Phenobarbital; Puromycin; Rats; Sex Factors; Time Factors | 1970 |
Cytochrome b5 and CO-binding cytochromes in the Golgi membranes of mammalian livers.
Topics: Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Copper; Cytochromes; Golgi Apparatus; Liver; Manganese; Membranes; Metabolism; Methylcholanthrene; Microscopy, Electron; Microsomes; Phenobarbital; Proteins; Rabbits; RNA; Sodium; Spectrophotometry | 1970 |
Induction of microsomal drug-metabolizing enzymes in regenerating liver.
Topics: Animals; Enzyme Induction; Hepatectomy; Liver Regeneration; Male; Methylcholanthrene; Microsomes, Liver; Pharmaceutical Preparations; Phenobarbital; Rats | 1970 |
The role of microsomal drug-metabolizing enzymes in the biliary excretion of 3,4-benzpyrene in the rat.
Topics: Animals; Benzopyrenes; Bile; Emetine; Enzyme Induction; Ethionine; Female; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Tritium; Water | 1970 |
Aminopyrine demethylase. Kinetic evidence for multiple microsomal activities.
Topics: Aminopyrine; Animals; Carbon Monoxide; Chromatography, Thin Layer; Cytochromes; Dealkylation; Enzyme Induction; Ethionine; Goats; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rats; Spectrophotometry; Stimulation, Chemical; Sulfites | 1970 |
Diphenylhydantoin-induced difference spectra with rat-liver microsomes.
Topics: Animals; Benzphetamine; Chlordan; DDT; Drug Interactions; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Spectrum Analysis | 1970 |
Influence of methylcholanthrene and phenobarbital treatment on liver chromatin template activity in the rat.
Topics: Acetates; Acylation; Adenosine Triphosphate; Adrenal Glands; Adrenalectomy; Animals; Arginine; Carbon Isotopes; Chromatin; Histones; Hydrochloric Acid; Liver; Lysine; Male; Methylcholanthrene; Micrococcus; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; RNA Nucleotidyltransferases; Templates, Genetic | 1970 |
Microsomal hydroxylase induction in liver cell culture by phenobarbital, polycyclic hydrocarbons, and p,p'-DDT.
Topics: Animals; Benz(a)Anthracenes; DDT; Enzyme Induction; Fetus; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Models, Biological; Phenobarbital; Rats | 1971 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions.
Topics: Animals; Benzopyrenes; Cytochromes; Dealkylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenethylamines; Phenobarbital; Rats | 1971 |
Effect of methylcholanthrene or phenobarbital pretreatment of rabbits and rats on the extinction coefficient for cytochrome P-450.
Topics: Animals; Cytochromes; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Rats | 1971 |
Diphenylhydantoin metabolism by rat liver microsomes and some of the effects of drug or chemical pretreatment on diphenylhydantoin metabolism by rat liver microsomal preparations.
Topics: Animals; Chlordan; DDT; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Spectrophotometry; Stimulation, Chemical | 1971 |
The influence of in vivo administration of dimethyl sulfoxide on the in vitro metabolism of some monocyclic aromatic chemicals by hepatic microsomal preparations.
Topics: Acetanilides; Aniline Compounds; Animals; Anisoles; Biotransformation; Cycloheximide; Cytochromes; Dactinomycin; Dimethyl Sulfoxide; Female; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Nitro Compounds; Phenobarbital; Rabbits; Rats; Stimulation, Chemical | 1971 |
Effect of phenobarbital and 3-methylcholanthrene pretreatment on guinea pig hepatic microsomal bilirubin glucuronyltransferase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Bilirubin; Cats; Colorimetry; Enzyme Activation; Glucuronates; Guinea Pigs; Kinetics; Male; Mathematics; Methylcholanthrene; Mice; Microsomes, Liver; Nucleoside Diphosphate Sugars; Phenobarbital; Rabbits; Rats; Species Specificity; Statistics as Topic; Time Factors; Transferases; Uracil Nucleotides | 1971 |
In vitro metabolic studies on propyl p-nitrophenyl ether.
Topics: 1-Propanol; Animals; Carbon Isotopes; Deuterium; Enzyme Induction; Ethers; Guinea Pigs; In Vitro Techniques; Male; Metabolism; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Propionates; Rats | 1971 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Organ Size; Phenobarbital; Phenothiazines; Proadifen; Puromycin; Urethane | 1971 |
The effect of methylcholanthrene, phenobarbital and aflatoxin on RNA polymerase of rat liver.
Topics: Aflatoxins; Animals; Bacteria; Cell Nucleus; DNA; Liver; Male; Methylcholanthrene; Phenobarbital; Quaternary Ammonium Compounds; Rats; RNA Nucleotidyltransferases; Sulfates | 1967 |
Cytochrome P-450 of liver microsomes--one pigment or many.
Topics: Animals; Cytochromes; Liver; Methylcholanthrene; Microsomes; Phenobarbital; Pigments, Biological; Rabbits; Spectrophotometry | 1968 |
Differences in the kinetics of benzpyrene hydroxylation by hepatic drug-metabolizing enzymes from phenobarbital and 3-methylcholanthrene-treated rats.
Topics: Animals; Benzopyrenes; Carcinogens; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Stimulation, Chemical | 1968 |
Hepatic drug metabolism after phenobarbital or 3-methylcholanthrene pretreatment of rats bearing a pituitary tumor.
Topics: Aminopyrine; Animals; Benzopyrenes; Hexobarbital; Liver; Male; Methylcholanthrene; Phenobarbital; Pituitary Neoplasms; Rats; Zoxazolamine | 1968 |
Alteration of the microsomal hemoprotein by 3-methylcholanthrene: effects of ethionine and actinomycin D.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochromes; Dactinomycin; Enzyme Induction; Ethionine; Liver; Male; Methionine; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rats; Solubility; Spectrophotometry | 1968 |
Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Cytochromes; Enzyme Induction; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Organ Size; Phenobarbital; Proteins; Rats | 1968 |
Phenobarbital and methylcholanthrene stimulation of rat liver chromatin template activity.
Topics: Animals; Carbon Isotopes; Chromosomes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Templates, Genetic | 1968 |
Studies on microsomal hydroxylation and the demonstration of a new carbon monoxide binding pigment in liver microsomes.
Topics: Age Factors; Animals; Carbon Monoxide; Chemical Phenomena; Chemistry; Cytochromes; Enzyme Induction; Freezing; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Testosterone | 1968 |
On the problem of possible other forms of cytochrome P450 in liver microsomes.
Topics: Animals; Benzopyrenes; Cytochromes; Female; Hexobarbital; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrum Analysis | 1969 |
Possible participation of cytochrome P-450 in cholesterol synthesis.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Dioxide; Carbon Isotopes; Cholesterol; Cytochromes; Depression, Chemical; Liver; Male; Methylcholanthrene; Microsomes; Oxygen; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
Studies on the incorporation of delta-aminolevulinic acid into microsomal hemoprotein: effect of 3-methylcholanthrene and phenobarbital.
Topics: Amino Acids; Animals; Cytochromes; Levulinic Acids; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Tritium | 1969 |
The migration of deuterium during aryl hydroxylation. II. Effect of induction of microsomal hydroxylases with phenobarbital or polycyclic aromatic hydrocarbons.
Topics: Acetanilides; Acetone; Animals; Benzopyrenes; Cats; Cricetinae; Depression, Chemical; Deuterium; Enzyme Induction; Female; Genetics; Guinea Pigs; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Mice; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Tritium | 1969 |
Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.
Topics: Acetates; Animals; Benzene Derivatives; Benzopyrenes; Body Weight; Cytochromes; Glycogen; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; Organ Size; Phenobarbital; Rats; Stimulation, Chemical | 1969 |
Induction of drug metabolism. II. Qualitative differences in the microsomal N-demethylating systems stimulated by polycyclic hydrocarbons and by phenobarbital.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Carbon Monoxide; Cyanides; Cytochromes; Depression, Chemical; Female; Formaldehyde; Kinetics; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphinans; Morphine; Phenobarbital; Proadifen; Rats; Sex Factors; Species Specificity; Stimulation, Chemical; Valerates | 1969 |
Factors affecting the rate of disappearance of amphetamine in rats.
Topics: Age Factors; Animals; Dextroamphetamine; Estradiol; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Sex Factors; Time Factors; Zoxazolamine | 1969 |
[Studies on the effect of ascorbic acid on the activity and biosynthesis of mixed function oxygenases, as well as the concentration of hemoproteins in the microsome fraction of guinea pig liver].
Topics: Acetanilides; Aminopyrine; Animals; Ascorbic Acid; Cytochromes; Ethionine; Guinea Pigs; Liver; Methylcholanthrene; Microsomes; Oxygenases; Phenobarbital; Scurvy; Stimulation, Chemical | 1969 |
Induction of drug metabolism. 3. Further information of a new P-450 hemoprotein after treatment of rats with 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Binding Sites; Blood Proteins; Cold Temperature; Cytochromes; Hexobarbital; Lipase; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Protein Binding; Proteins; Rats | 1969 |
The influence of age, sex and drug treatment on microsomal drug metabolism in four rat strains.
Topics: Age Factors; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphine; Phenobarbital; Proteins; Rabbits; Rats; Sex Factors; Species Specificity | 1969 |
Ligand interactions with cytochrome P-450. I. Binding of primary amines.
Topics: Alcohols; Alkanes; Amines; Animals; Cyanides; Cytochromes; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Rabbits; Spectrophotometry; Stimulation, Chemical | 1969 |
Origin of delayed development of drug metabolism in the newborn rat.
Topics: Animals; Animals, Newborn; Coumarins; Female; Methylcholanthrene; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Sleep; Time Factors | 1969 |
Biphasic decrease of radioactive hemoprotein from liver microsomal carbon monoxide-binding particles. Effect of phenobarbital and chlordane.
Topics: Age Factors; Animals; Carbon Monoxide; Chlordan; Cytochromes; Levulinic Acids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Tritium | 1969 |
Stereoselective metabolism of the enantiomers of hexobarbital.
Topics: Animals; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Sleep; Stereoisomerism; Time Factors | 1969 |
The effect of two carcinostatic agents on the chemically induced stimulation of amino acid incorporation in a mammalian system.
Topics: Amino Acids; Animals; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes; Phenobarbital; Phenylalanine; Polynucleotides; Protein Biosynthesis; Rats; Subcellular Fractions; Uracil Nucleotides | 1965 |
Metabolism of volatile anesthetics. 3. Induction of microsomal dechlorinating and ether-cleaving enzymes.
Topics: Animals; Carbon Dioxide; Enzyme Induction; Halothane; In Vitro Techniques; Liver; Methoxyflurane; Methylcholanthrene; Microsomes; Phenobarbital; Rats | 1966 |
The stimulation of amino acid incorporation in a mammalian system with phenobarbital, 3-methylcholanthrene and cycloheximide.
Topics: Adrenalectomy; Amino Acids; Animals; Anti-Bacterial Agents; Hypophysectomy; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes; Phenobarbital; Phenylalanine; Rats | 1966 |
Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats.
Topics: Animals; Cyanides; Cytochromes; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes; Morphine; Phenobarbital; Rats; Spectrophotometry; Transferases | 1966 |
3-methylcholanthrene and phenobarbital stimulation of rat liver RNA polymerase.
Topics: Animals; Cattle; Genes; Liver; Male; Methylcholanthrene; Microsomes; Nucleosides; Nucleotidyltransferases; Phenobarbital; Rats; RNA; Thymus Gland; Tritium | 1967 |
Effect of pretreatment of rabbits with phenobarbital or 3-methylcholanthrene on the distribution of drug-metabolizing enzyme activity in subfractions of hepatic microsomes.
Topics: Aminopyrine; Amphetamine; Animals; Benzopyrenes; Codeine; Hexobarbital; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rabbits; Zoxazolamine | 1967 |
Anesthesia. LXXIV. Biotransformation of fluroxene. I. Metabolism in mice and dogs in vivo.
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Isotopes; Chemical and Drug Induced Liver Injury; Dactinomycin; Dogs; Ethers; Ethyl Ethers; Ethylamines; Female; Male; Methylcholanthrene; Mice; Nitrous Oxide; Phenobarbital; Proadifen | 1967 |
Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol.
Topics: Acetaminophen; Alanine Transaminase; Alcohols; Animals; Carbon Tetrachloride; Drug Synergism; Ethanol; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylethyl Alcohol; Rats; Rats, Inbred Strains | 1984 |
In vivo spin-trap study on anaerobic dehalogenation of halothane.
Topics: Anaerobiosis; Animals; Electron Spin Resonance Spectroscopy; Free Radicals; Halothane; Humans; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cytochrome P-450 Enzyme System; DNA; DNA Restriction Enzymes; Enzyme Induction; Genes; Methylcholanthrene; Nucleic Acid Hybridization; Phenobarbital; Plasmids; Rats | 1984 |
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole | 1984 |
Induction studies of delta 1-tetrahydrocannabinol metabolism by rat and rabbit lungs.
Topics: Aging; Animals; Dronabinol; Enzyme Induction; Lung; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Subcellular Fractions | 1981 |
Reaction schemes for the degradation of cytochrome P-450 by allyl-iso-propylacetamide and fluroxene.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Ethers; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1981 |
Comparison of detoxication activity in midgut and fat body during fifth instar development of the tobacco hornworm, Manduca sexta.
Topics: Adipose Tissue; Animals; Cytochrome P-450 Enzyme System; Digestive System Physiological Phenomena; Fat Body; Inactivation, Metabolic; Lepidoptera; Methylcholanthrene; Microsomes; Phenobarbital; Time Factors | 1982 |
The accumulation of distinct mRNAs for the immunochemically related cytochromes P-450c and P-450d in rat liver following 3-methylcholanthrene treatment.
Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Isoenzymes; Liver; Male; Methylcholanthrene; Molecular Weight; Nucleic Acid Hybridization; Phenobarbital; Poly A; Protein Biosynthesis; Rats; RNA, Messenger; Transcription, Genetic | 1983 |
Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies.
Topics: Animals; Barbiturates; Drug Interactions; Half-Life; Hexobarbital; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Effects of species, MFO inducers and conjugation agents on the in vitro covalent binding of 14C-3-methylindole metabolite in liver and lung tissues.
Topics: Animals; Enzyme Induction; Female; Goats; Indoles; Liver; Lung; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Skatole; Species Specificity | 1983 |
In vivo effects of 3-methylcholanthrene, phenobarbital, pyrethrum and 2,4,5-T isooctylester on liver, lung and kidney microsomal mixed-function oxidase system of guinea-pig: a comparative study.
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Chrysanthemum cinerariifolium; Ethylmorphine-N-Demethylase; Guinea Pigs; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1984 |
Quantitation of norantipyrine sulphate and norantipyrine glucuronide as major metabolites of antipyrine in man and rat.
Topics: Adult; Animals; Antipyrine; Chromatography, Thin Layer; Edaravone; Glucuronates; Humans; Hydrolysis; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Solubility; Sulfates | 1984 |
[Spectral changes in the liver microsomal cytochrome P-450 of rats during interaction with phenazepam and its 3-hydroxy metabolite].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Cytochrome P-450 Enzyme System; Drug Interactions; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry | 1984 |
Position-specific induction of benzo(a)pyrene metabolism by 3-methylcholanthrene and phenobarbital in mullet (Mugil cephalus), a marine fish.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Chemical Phenomena; Chemistry; Enzyme Induction; Epoxide Hydrolases; Fishes; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Trichloroepoxypropane | 1984 |
The effect of monooxygenase inducing agents on the incorporation of [35S]methionine into hepatic microsomal protein of rainbow trout (Salmo gairdneri).
Topics: Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Methionine; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Rosaniline Dyes; Salmonidae; Time Factors; Trout | 1984 |
Conversion of procarcinogens to mutagens by the S-9 fraction from the liver of rainbow trout (Salmo gairdneri): inducibility with PCB, 3-methylcholanthrene and phenobarbital and inhibition by metyrapone and alpha-naphthoflavone.
Topics: 2-Acetylaminofluorene; Animals; Anthracenes; Benzo(a)pyrene; Benzoflavones; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mutagenicity Tests; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonidae; Subcellular Fractions; Temperature; Trout | 1984 |
A comparative study of the early effects of phenobarbital and 3-methylcholanthrene on the synthesis and transport of ribonucleic acid in rat liver.
Topics: Animals; Biological Transport; Cell Nucleus; Cytoplasm; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Polyribosomes; Rats; RNA | 1980 |
Hepatic microsomal metabolism of N-nitrosodimethylamine to its methylating agent.
Topics: Alkylating Agents; Animals; Dimethylnitrosamine; DNA; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Proteins; Rats; RNA | 1980 |
Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Epitopes; Epoxide Hydrolases; Female; Immunodiffusion; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sex Factors; Sexual Maturation; Steroid 16-alpha-Hydroxylase | 1981 |
Regulation of the synthesis of cytochrome P-450 in liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Methylcholanthrene; Phenobarbital; Poly A; Protein Biosynthesis; Rats; RNA; RNA, Messenger | 1981 |
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epitopes; Humans; Hybridomas; Immunization; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats | 1982 |
Enhancement of carrageenan and dextran-induced edemas by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Topics: Animals; Body Weight; Carrageenan; Cytochrome P-450 Enzyme System; Dextrans; Dioxins; Dose-Response Relationship, Drug; Drug Synergism; Edema; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Thymus Gland | 1983 |
Monoclonal antibody-directed phenotyping of cytochrome P-450-dependent aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase in mammalian tissues.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Aryl Hydrocarbon Hydroxylases; Cricetinae; Cytochrome P-450 Enzyme System; Epitopes; Kinetics; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Oxygenases; Phenobarbital; Phenotype; Rats; Rats, Inbred Strains | 1984 |
Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA.
Topics: Animals; Cloning, Molecular; Cross Reactions; DNA; Glucuronosyltransferase; Immunodiffusion; Liver; Male; Methylcholanthrene; Mice; Microscopy, Electron; Nucleic Acid Hybridization; Phenobarbital; Poly A; Rats; Rats, Inbred Strains; RNA; RNA, Messenger | 1984 |
Effect of drugs and hormones on rat liver dimethylaminoazobenzene reductase activity.
Topics: Allylisopropylacetamide; Amitrole; Animals; Cytochrome P-450 Enzyme System; Female; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADH, NADPH Oxidoreductases; p-Dimethylaminoazobenzene; Phenobarbital; Rats; Rats, Inbred Strains; Streptozocin; Thyroxine | 1982 |
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.
Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine | 1984 |
Effect of ascorbic acid and some reducing agents on N-nitrosopiperidine metabolism by liver microsomes.
Topics: Aldehydes; Animals; Ascorbic Acid; Carcinogens; Guinea Pigs; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Nitroso Compounds; Oxidation-Reduction; Phenobarbital | 1984 |
Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster.
Topics: Animals; Benzopyrene Hydroxylase; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Flame Retardants; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Polybrominated Biphenyls; Rats; Spectrophotometry | 1980 |
Alteration in enzyme activities of de novo phosphatidylcholine biosynthesis in rat liver by treatment with typical inducers of microsomal drug-metabolizing system.
Topics: Animals; Choline Kinase; Choline-Phosphate Cytidylyltransferase; Cytidine Diphosphate Choline; Diacylglycerol Cholinephosphotransferase; Enzyme Induction; Ethanolamines; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nucleotidyltransferases; Phenobarbital; Phosphatidylcholines; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Polychlorinated Biphenyls; Rats | 1980 |
Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. II. Spectral properties.
Topics: Acetanilides; Aniline Compounds; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rabbits; Spectrophotometry | 1980 |
Altered metabolism of progesterone by hepatic microsomes from rats following dietary exposure to polybrominated biphenyls.
Topics: Animals; Biphenyl Compounds; Endocrine Glands; Female; Hydroxyprogesterones; In Vitro Techniques; Male; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polybrominated Biphenyls; Pregnancy; Progesterone; Rats; Sex Factors | 1980 |
Induction of choline kinase by polycyclic aromatic hydrocarbon carcinogens in rat liver.
Topics: Animals; Carcinogens; Choline Kinase; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phosphotransferases; Polycyclic Compounds; Rats | 1980 |
Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3',4,4',5-hexabromobiphenyl, a component of fireMaster.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Flame Retardants; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polybrominated Biphenyls; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1981 |
Metabolism of 3-methylcholanthrene in rat pancreas.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; In Vitro Techniques; Injections, Intraperitoneal; Liver; Male; Methylcholanthrene; Pancreas; Phenobarbital; Rats; Time Factors | 1981 |
Comparative induction of xenobiotic metabolism in rodent kidney, testis and liver by commercial mixtures of polybrominated biphenyls and polychlorinated biphenyls, phenobarbital and 3-methylcholanthrene: absolute and temporal effects.
Topics: Animals; Biphenyl Compounds; Drug Interactions; Enzyme Induction; Kidney; Liver; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Polybrominated Biphenyls; Polychlorinated Biphenyls; Rats; Rats, Inbred F344; Testis; Time Factors | 1981 |
Effects of phenobarbital, 3-methylcholanthrene and beta-naphthoflavone pretreatment on mouse liver microsomal enzymes and on metabolite patterns of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Proteins | 1981 |
Effects of butylated hydroxyanisole on the aryl hydrocarbon hydroxylase of rats and mice.
Topics: Animals; Anisoles; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Nucleus; Female; Lung; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Skin | 1981 |
Effect of certain neurotoxins and mixed function oxidase modifiers on glutathione-S-transferase activity of rat brain.
Topics: Acrylamide; Acrylamides; Animals; Benzo(a)pyrene; Benzopyrenes; Brain; Dinitrochlorobenzene; Glutathione Transferase; Male; Methylcholanthrene; Mixed Function Oxygenases; Nervous System; Oxidoreductases; Phenobarbital; Rats; Styrene; Styrenes | 1981 |
Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Female; Guinea Pigs; Male; Mesocricetus; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
The damage of the hepatic mixed functional oxygenase system by CCl4: significance of incorporation of 14CCl4 metabolites in vivo.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholecalciferol; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Cytochromes b5; Female; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Inactivation, Metabolic; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Characteristics of microsomal reduction of benzo[a]pyrene 4,5-oxide.
Topics: Anaerobiosis; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Fractionation; Cytochrome P-450 Enzyme System; Cytosol; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Phosphatidylcholines; Rats | 1982 |
Roles of UDP-glucuronosyltransferase in the inactivation of benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Enzyme Induction; Glucuronosyltransferase; Kinetics; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Structure-Activity Relationship; Substrate Specificity; Tissue Distribution | 1981 |
Metabolism of benzo(a)pyrene and benzo(a)pyrene 4,5-oxide in rabbit lung.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Glutathione Transferase; Lung; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits | 1981 |
Liver microsomal enzyme induction and toxicity studies with 2,4,5,3',4'-pentabromobiphenyl.
Topics: Animals; Biphenyl Compounds; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flame Retardants; Lipid Metabolism; Lymphocytes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polybrominated Biphenyls; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1982 |
Systemic excretion of benzo(a)pyrene in the control and microsomally induced rat: the influence of plasma lipoproteins and albumin as carrier molecules.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzopyrenes; Carbon Radioisotopes; Carcinogens; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Humans; Kinetics; Lipoproteins; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Serum Albumin; Tritium | 1983 |
Induction of drug metabolizing enzymes in the liver of diabetic mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Diabetes Mellitus, Experimental; Enzyme Induction; In Vitro Techniques; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital | 1982 |
8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes.
Topics: Animals; Cobalt; Dronabinol; Isomerism; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; NADP; Phenobarbital | 1982 |
Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit.
Topics: Animals; Arrhythmias, Cardiac; Benzo(a)pyrene; Benzopyrenes; Epinephrine; Ethylene Chlorohydrin; Halothane; Male; Methylcholanthrene; Phenobarbital; Rabbits; Time Factors; Trichloroacetic Acid; Trichloroethylene | 1983 |
Covalent binding of benzo[a]pyrene to rat liver cytosolic proteins and its effect on the binding to microsomal proteins.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cytosol; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains | 1983 |
Inhibition by 17-alpha-ethinyl estradiol of benzo[a]-pyrene metabolism in isolated adult rat hepatocytes.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; DNA; Ethinyl Estradiol; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Effect of some xenobiotics on kynurenine hydrolase and kynurenine aminotransferase of mouse liver.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinogens; Chlorodiphenyl (54% Chlorine); Chlorpromazine; Female; Hydrolases; Liver; Lyases; Methylcholanthrene; Mice; Phenobarbital; Pyrazoles; Transaminases | 1983 |
The properties of UDP-glucuronyltransferase for cannabinoids in rat liver microsomes.
Topics: Animals; Cannabidiol; Cannabinoids; Cannabinol; Dronabinol; Glucuronosyltransferase; In Vitro Techniques; Kinetics; Methylcholanthrene; Microsomes, Liver; Octoxynol; Phenobarbital; Polyethylene Glycols; Rats; Uridine Diphosphate N-Acetylglucosamine | 1983 |
The effects of phenobarbital, 3-methylcholanthrene and benzo(a)pyrene on the hydrolysis of xenobiotics in the rat.
Topics: 2-Acetylaminofluorene; Acetanilides; Amidohydrolases; Animals; Aspirin; Benzo(a)pyrene; Benzopyrenes; Carboxylic Ester Hydrolases; Female; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Procaine; Rats; Tissue Distribution | 1983 |
Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse liver macromolecules.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Dimethylnitrosamine; DNA; Indoles; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Rats | 1984 |
Distribution and some characteristics of cytochrome P-450 in the kidney.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Fasting; Hydroxylation; In Vitro Techniques; Kidney Tubules, Proximal; Laurates; Male; Methylcholanthrene; Microsomes; Nephrons; Phenobarbital; Rabbits; Rats | 1983 |
Elevated binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene to the Ah receptor in hepatic cytosols from phenobarbital-treated rats and mice.
Topics: Animals; Cytosol; Dioxins; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1984 |
Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; DNA; DNA Restriction Enzymes; Glutathione Transferase; Liver; Methylcholanthrene; Molecular Weight; Nucleic Acid Hybridization; Phenobarbital; Plasmids; Polyribosomes; Rats; RNA, Messenger; Transcription, Genetic | 1984 |
Comparison of hepatic drug-metabolizing enzymes induced by 3-methylcholanthrene and phenobarbital between pre- and postnatal rats.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Gestational Age; Hexobarbital; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
Glucose-6-phosphatase activities in the developing rat liver and kidney and after phenobarbital, 3-methylcholanthrene, and actinomycin D pretreatment.
Topics: Aging; Animals; Animals, Laboratory; Animals, Newborn; Dactinomycin; Glucose-6-Phosphatase; Kidney; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
[Correlation between cytochrome P-448 content and benzopyrene hydroxylase activity during the induction of microsomal monooxygenases using methylcholanthrene-type xenobiotics].
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Dioxins; Immunoelectrophoresis; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1984 |
Morphine metabolism revisited: I. Metabolic activation of morphine to a reactive species in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Cytochrome P-450 Enzyme System; Dihydromorphine; Enzyme Induction; Glutathione; Liver; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1984 |
7-Ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: regulation in cultured rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminolevulinic Acid; Animals; Bucladesine; Cells, Cultured; Dexamethasone; Enzyme Induction; Glucagon; Heme; Insulin; Liver; Methylcholanthrene; Niacinamide; Oxygenases; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains | 1984 |
[Isolation and characterization of the basic forms of cytochrome P-450 from liver microsomes of C57BL mice after phenobarbital and 3-methylcholanthrene induction].
Topics: Aminopyrine; Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Weight; Phenobarbital; Substrate Specificity | 1984 |
Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Immunochemistry; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Effects of phenobarbital, trans-stilbene oxide, and 3-methylcholanthrene on epoxide hydrolase within centrilobular, midzonal, and periportal regions of rat liver.
Topics: Animals; Epoxide Hydrolases; Fluorescent Antibody Technique; Histocytochemistry; Male; Methylcholanthrene; Microsomes, Liver; Organ Specificity; Phenobarbital; Rats; Stilbenes | 1983 |
High mutagenic potency of several polycyclic aromatic hydrocarbons induced by liver postmitochondrial fractions from control and xenobiotic-treated immature carp.
Topics: Animals; Aroclors; Biotransformation; Carps; Chlorodiphenyl (54% Chlorine); Methylcholanthrene; Microsomes, Liver; Mutagens; Mutation; Phenobarbital; Polycyclic Compounds; Rats; Salmonella typhimurium; Species Specificity | 1983 |
A biochemical and electron microscopic study of changes in the content of cytochrome P-450 in rat livers after cessation of treatment with phenobarbital, beta-naphtoflavone or 3-methylcholanthrene.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Flavonoids; Immunosorbent Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
A study on the mutagenic effect of some Bulgarian drugs using the Salmonella/microsome test.
Topics: Animals; Biotransformation; Bulgaria; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; In Vitro Techniques; Liver; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1983 |
Induction of cytochrome P-450 isozymes in rat hepatoma-derived cell cultures.
Topics: Animals; Cell Line; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Immunosorbent Techniques; Isoenzymes; Kinetics; Liver; Liver Neoplasms, Experimental; Methylcholanthrene; Phenobarbital; Protein Biosynthesis; Rats; RNA, Messenger | 1984 |
A dual assay for the specific screening of 3-methylcholanthrene- and phenobarbital-like chemical inducers of cytochrome P-450 monooxygenases.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred DBA; Microsomes, Liver; Mutagenicity Tests; Mutagens; Mutation; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship | 1984 |
Ethanol as an inducer of UDP-glucuronyltransferase: a comparison with phenobarbital and 3-methylcholanthrene induction in rabbit hepatic microsomes.
Topics: Animals; Enzyme Induction; Ethanol; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits | 1983 |
Development of basal and induced aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity in the chicken embryo in ovo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cell Differentiation; Chick Embryo; Chickens; Enzyme Induction; Kinetics; Liver; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins | 1983 |
Immunochemical evidence for two 3-methylcholanthrene-inducible forms of cytochrome P-448 in rat liver microsomes using a double-antibody radioimmunoassay procedure.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Radioimmunoassay; Rats | 1983 |
Modifying effects of the enzyme inducers, phenobarbital and 3-methylcholanthrene, on dominant lethal events induced by 7, 12-dimethylbenz[a]anthracene in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Genes, Dominant; Genes, Lethal; Male; Meiosis; Methylcholanthrene; Mice; Mutation; Phenobarbital; Pregnancy; Spermatozoa; Time Factors | 1983 |
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1983 |
The metabolism of aflatoxin B1 by hepatocytes isolated from rats following the in vivo administration of some xenobiotics.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carbon Radioisotopes; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred F344 | 1983 |
Characterisation of hepatocyte sub-populations generated by centrifugal elutriation.
Topics: Acridine Orange; Animals; Cell Separation; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorescein-5-isothiocyanate; Fluoresceins; Fluorescent Dyes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Thiocyanates | 1983 |
Turnover of two drug-inducible forms of microsomal cytochrome P-450 in rat liver.
Topics: Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Half-Life; Heme; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Comparison of the inducibilities of UDP-glucuronosyltransferase and polysubstrate monooxygenase activities in mice exposed to 20 model xenobiotics.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Enzyme Induction; Glucuronosyltransferase; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins | 1983 |
Polychlorinated biphenyls as phenobarbitone-type inducers of microsomal enzymes. Structure-activity relationships for a series of 2,4-dichloro-substituted congeners.
Topics: Animals; Benzopyrene Hydroxylase; Cytochrome b Group; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytochromes b5; Drug Interactions; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
Adipose tissue content as a modifier of the tissue distribution, biological effects, and excretion of a hexachlorobiphenyl in C57BL/6J and DBA/JBOMf mice.
Topics: Adipose Tissue; Animals; Cytosol; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Species Specificity; Tissue Distribution | 1983 |
Activation of 3,4,3',4'-tetrachlorobiphenyl to protein-bound metabolites by rat liver microsomal cytochrome P-448-containing monooxygenase system.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity | 1983 |
Intralobular distribution of UDP-glucuronosyltransferase in livers from untreated, 3-methylcholanthrene- and phenobarbital-treated rats.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Histocytochemistry; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Glucuronide formation of various drugs in liver microsomes and in isolated hepatocytes from phenobarbital- and 3-methylcholanthrene-treated rats.
Topics: Animals; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A.
Topics: Animals; Aroclors; Benzene; Bone Marrow; Cell Nucleus; Chlorodiphenyl (54% Chlorine); Drug Interactions; Female; Male; Metaphase; Methylcholanthrene; Mice; Mutagenicity Tests; Mutagens; Mutation; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Sex Factors; Toluene | 1984 |
An enzyme-linked immunoadsorbent assay for measuring cytochrome b5 and NADPH-cytochrome P-450 reductase in rat liver microsomal fractions. Evidence for functionally inactive protein.
Topics: Age Factors; Animals; Cytochrome b Group; Cytochromes b5; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors; Spectrophotometry | 1984 |
Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital-type and 3-methylcholanthrene-type polychlorinated biphenyls in rats.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Rats; Rats, Inbred Strains | 1983 |
Purification and characterization of four forms of cytochrome P-450 from liver microsomes of phenobarbital-treated and 3-methylcholanthrene-treated rats.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1984 |
Rat liver DT-diaphorase: regulation of functional mRNA levels by 3-methylcholanthrene, trans-stilbene oxide, and phenobarbital.
Topics: Animals; Cell-Free System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunochemistry; Liver; Methylcholanthrene; NAD(P)H Dehydrogenase (Quinone); NADH, NADPH Oxidoreductases; Phenobarbital; Quinone Reductases; Rabbits; Rats; RNA, Messenger; Stilbenes | 1984 |
Effect of carbohydrate intake on phenobarbital-, polychlorinated biphenyl- and 3-methylcholanthrene-induced enhancement of drug oxidation in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxidation-Reduction; Oxygenases; Pharmaceutical Preparations; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1984 |
Purification and characterization of the major microsomal cytochrome P-450 form induced by trans-stilbene oxide in rat liver.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunodiffusion; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes | 1984 |
Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats.
Topics: Androsterone; Animals; Corticosterone; Estradiol; Female; Glucuronosyltransferase; Gonadal Steroid Hormones; Liver; Male; Methylcholanthrene; Milk; Nitrophenols; Phenobarbital; Phenotype; Rats; Rats, Inbred Strains; Sexual Maturation | 1984 |
Cleavage of nascent UDP glucuronosyltransferase from rat liver by dog pancreatic microsomes.
Topics: Animals; Antigen-Antibody Complex; Dogs; Enzyme Induction; Glucuronosyltransferase; Immune Sera; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Molecular Weight; Pancreas; Phenobarbital; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1984 |
Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Substrate Specificity | 1984 |
Induction of hepatic microsomal drug metabolism by azo compounds: a structure-activity relationship.
Topics: Animals; Azo Compounds; Coloring Agents; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Glucuronosyltransferase; Kinetics; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Structure-Activity Relationship | 1984 |
Glucuronic acid conjugation by hepatic microsomal fractions isolated from streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Enzyme Induction; Female; Glucuronates; Glucuronosyltransferase; Insulin; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
2,2-Dimethyl-5-t-butyl-1,3-benzodioxole: an unusual inducer of microsomal enzymes.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Epoxide Hydrolases; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital | 1984 |
Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes.
Topics: Animals; Carcinogens; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Proadifen; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 1984 |
[Effects of carbohydrate intake on phenobarbital-, polychlorinated biphenyl- and 3-methylcholanthrene-induced enhancement of drug oxidation and conjugation in rat liver].
Topics: Animals; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1984 |
Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; Binding, Competitive; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnanolone; Progesterone; Rats; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Steroids; Substrate Specificity; Testosterone | 1981 |
Induction of cytosolic glutathione transferase and microsomal epoxide hydrolase activities in extrahepatic organs of the rat by phenobarbital, 3-methylcholanthrene and trans-stilbene oxide.
Topics: Animals; Cytosol; Epoxide Hydrolases; Glutathione Transferase; Male; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Rats, Inbred Strains; Stilbenes; Time Factors; Tissue Distribution | 1984 |
Induction of cytochrome P-450 mRNAs quantitated by in vitro translation and immunoprecipitation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Autoradiography; Benzoflavones; beta-Naphthoflavone; Chemical Precipitation; Cytochrome P-450 Enzyme System; Densitometry; Electrophoresis, Polyacrylamide Gel; Female; Immunochemistry; Kinetics; Male; Methylcholanthrene; Phenobarbital; Photofluorography; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA, Messenger; Sex Characteristics | 1984 |
[Mechanism of the protective effect of modifiers of the liver enzyme systems metabolyzing xenobiotics in acute T-2 mycotoxicosis].
Topics: Acute Disease; Animals; Cobalt; Drug Evaluation, Preclinical; Enzyme Induction; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Sesquiterpenes; T-2 Toxin | 1984 |
Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: I. The role of peroxidation of membrane phospholipids.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Hydroxylation; In Vitro Techniques; Kinetics; Lipid Peroxides; Liver; Male; Membrane Lipids; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Phospholipids; Rats | 1984 |
Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: II. The interrelation between lipid peroxidation and proteolytic degradation of cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Hydrolysis; Kinetics; Lipid Peroxides; Liver; Male; Membranes; Methylcholanthrene; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Trypsin | 1984 |
Resolution of multiple forms of cytochrome P-450 by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytosol; Epoxide Hydrolases; Glutathione; Glutathione Transferase; In Vitro Techniques; Lung; Male; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Naphthalenes; Phenobarbital; Piperonyl Butoxide; Proadifen; Proteins | 1984 |
Ethylenethiourea-induced hindpaw deformities in mice and effects of metabolic modifiers on their occurrence.
Topics: Abnormalities, Drug-Induced; Animals; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Foot Deformities, Congenital; Hindlimb; Imidazoles; Methylcholanthrene; Mice; Phenobarbital; Pregnancy; Proadifen; Species Specificity | 1984 |
Macromolecular weight specificity in covalent binding of bromobenzene.
Topics: Animals; Bromobenzenes; Carbon Radioisotopes; Liver; Macromolecular Substances; Male; Methylcholanthrene; Molecular Weight; Phenobarbital; Phenylmethylsulfonyl Fluoride; Proteins; Rats; Rats, Inbred F344 | 1984 |
The metabolism of 1-hydroxy- and 2-hydroxy-3-methylcholanthrene by liver microsomes: effect of enzyme inducing agents.
Topics: Animals; Aroclors; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1984 |
Hepatic mixed-function oxidase activities of wild pigeons.
Topics: Animals; Columbidae; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Species Specificity | 1984 |
Decreased hepatic vitamin A after drug administration in men and in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Humans; Kidney; Liver; Liver Diseases; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Vitamin A | 1984 |
In vitro hepatic enzyme activity in rats exposed nose-only to cigarette smoke.
Topics: Animals; Body Weight; Carboxyhemoglobin; Glutathione; In Vitro Techniques; Liver; Male; Methylcholanthrene; Nicotiana; Organ Size; Pentobarbital; Phenobarbital; Plants, Toxic; Rats; Rats, Inbred Strains; Smoke | 1984 |
Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells.
Topics: Animals; Biotransformation; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Liver Neoplasms, Experimental; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Rats; Spectrum Analysis | 1984 |
An induction effect of phenobarbital on rat liver microsomal 4-hydroxylation of estradiol 17-sulfate.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Estradiol; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1984 |
Regulation of glutathione S-transferase mRNAs by phenobarbital and 3-methylcholanthrene: analysis using cDNA probes.
Topics: Animals; DNA; Enzyme Induction; Glutathione Transferase; In Vitro Techniques; Liver; Methylcholanthrene; Phenobarbital; Protein Biosynthesis; Protein Conformation; Rats; RNA, Messenger | 1984 |
Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b.
Topics: Amino Acid Sequence; Animals; Base Sequence; Clofibrate; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Methylcholanthrene; Mice; Phenobarbital; Rabbits; Rats; Species Specificity | 1984 |
Glutathione S-transferase activity in rat pancreas.
Topics: Animals; Biotransformation; Enzyme Induction; Glutathione Transferase; Liver; Methylcholanthrene; Pancreas; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Rat liver sulfotransferases: effects of gonadal hormones and other factors on enzyme activities.
Topics: Aging; Androsterone; Animals; Body Weight; Corticosterone; Cytosol; Estradiol; Gonadal Steroid Hormones; Liver; Male; Methylcholanthrene; Nitrophenols; Organ Size; Phenobarbital; Progesterone; Rats; Rats, Inbred Strains; Sulfurtransferases; Testosterone | 1984 |
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Glutathione; Male; Methylcholanthrene; Oleandomycin; Phenobarbital; Rats; Rats, Inbred Strains; Troleandomycin | 1983 |
Effects of phenobarbital and 3-methylcholanthrene pretreatments on monooxygenase activities and proportions of isolated rat hepatocyte subpopulations.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cell Separation; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Glutathione; Liver; Liver Glycogen; Male; Methylcholanthrene; Microscopy, Electron; Oxidoreductases; Oxygenases; Phenobarbital; Rats | 1983 |
7-Ethoxycoumarin O-de-ethylase activity in rat brain microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Brain; Enzyme Induction; Male; Methylcholanthrene; Microsomes; NAD; NADP; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Glucuronidation and sulfation of p-nitrophenol in isolated rat hepatocyte subpopulations. Effects of phenobarbital and 3-methylcholanthrene pretreatment.
Topics: 4-Aminobenzoic Acid; Animals; Cytochrome P-450 Enzyme System; Glucuronates; In Vitro Techniques; Liver; Male; Methylcholanthrene; Nitrobenzenes; Nitrophenols; Phenobarbital; Rats; Rats, Inbred Strains; Sulfates | 1983 |
Induction of hepatic microsomal cytochrome P-450 and associated monooxygenases by pentamethylbenzene in the rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1983 |
The effects of twenty-two organochlorine pesticides as inducers of the hepatic drug-metabolizing enzymes.
Topics: Animals; Cyclohexanes; DDT; Enzyme Induction; Hexachlorobenzene; Insecticides; Liver; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Rats; Toxaphene | 1983 |
Heavy metals and enzyme induction.
Topics: Animals; Enzyme Induction; Male; Metals; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
The metabolism of 3-methylcholanthrene by liver and lung microsomes: effect of enzyme inducing agents.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Metabolism of estradiol in liver cell culture. Differential responses of C-2 and C-16 oxidations to drugs and other chemicals that induce selective species of cytochrome P-450.
Topics: Allylisopropylacetamide; Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Cell Count; Cells, Cultured; Chick Embryo; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Estradiol; Liver; Methylcholanthrene; Phenobarbital | 1983 |
Induction of liver microsomal 2-hydroxylation of estradiol 17-sulfate by phenobarbital in male rat.
Topics: Animals; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 Enzyme System; Estradiol; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Influence of cigarette smoke on antipyrine metabolite formation in rats.
Topics: Animals; Antipyrine; Biotransformation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Smoking | 1983 |
Polychlorinated benzene and phenol congeners as inducers of rat hepatic drug-metabolizing enzymes in immature male Wistar rats.
Topics: Animals; Chlorobenzenes; Chlorophenols; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Nonadditive effects of combined in vivo hepatic microsomal enzyme inducers in the Wistar rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Stilbenes | 1983 |
Reversible transfer of heme between different molecular species of microsome-bound cytochrome P-450 in rat liver.
Topics: Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Heme; Isoenzymes; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1983 |
Monoclonal antibody-directed immunopurification and identification of cytochromes P-450.
Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Cytochrome P-450 Enzyme System; Enzyme Induction; Hybridomas; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Plasmacytoma; Rats; Rats, Inbred Strains | 1983 |
The metabolism of 4-substituted N-ethyl-N-methylanilines. III. Effect of various potential inhibitors, activators and inducers on alpha-C- and N-oxidation.
Topics: Aniline Compounds; Animals; Carbon Monoxide; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital | 1983 |
Effect of phenobarbital and 3-methylcholanthrene on the hepatic microsomal metabolism of N-nitrosodimethylamine, N-nitrosomethylbutylamine and N-nitrosomethylbenzylamine.
Topics: Animals; Chromatography, Gas; Dimethylnitrosamine; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidoreductases, N-Demethylating; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Influence of phenobarbital and 3-methylcholanthrene on the metabolism of aminopyrine in isolated hepatocyte system.
Topics: Aminopyrine; Animals; Chromatography, High Pressure Liquid; Dipyrone; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains | 1983 |
[Estimation of drug-metabolizing enzyme activities by measuring urinary metabolites of aspirin].
Topics: Animals; Aspirin; Biotransformation; Body Weight; Cytochrome P-450 Enzyme System; Gentisates; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Salicylates | 1983 |
Metabolism of tetraorganolead compounds by rat-liver microsomal mono-oxygenase. II. Enzymic dealkylation of tetraethyl lead.
Topics: Animals; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Organometallic Compounds; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Tetraethyl Lead | 1983 |
Comparative effects of dietary administration of antioxidants and inducers on the activities of several hepatic enzymes in mice.
Topics: Animals; Antioxidants; Aroclors; Chlorodiphenyl (54% Chlorine); Cytosol; Diet; Enzyme Induction; Female; Glutathione Reductase; Glutathione Transferase; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Phenobarbital; Sulfhydryl Compounds | 1983 |
Cadmium administration and hepatic drug metabolizing enzyme system: effect of pretreatment with phenobarbital and 3-methyl cholanthrene.
Topics: Aniline Hydroxylase; Animals; Cadmium; Cytochrome P-450 Enzyme System; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proteins; Rats; Rats, Inbred Strains | 1983 |
Dinemorphan N-demethylation by mouse liver microsomes.
Topics: Animals; Antitussive Agents; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphinans; Oxidoreductases, N-Demethylating; Phenobarbital | 1984 |
The induction of cytochrome P-450 and monooxygenase activities in the chick embryo by 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Electron Transport; Enzyme Induction; Epoxide Hydrolases; Female; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital | 1984 |
Induction of xenobiotic-metabolizing enzymes by trans-stilbene oxide and 2-acetylaminofluorene: observations on enzyme induction by drugs.
Topics: 2-Acetylaminofluorene; Animals; Enzyme Induction; Enzymes; Liver; Male; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Rats; Stilbenes | 1984 |
Effects of hypophysectomy on sex differences in the induction and depression of hepatic drug-metabolizing enzymes in the rat.
Topics: Aniline Compounds; Animals; Chromatography, Gas; Epoxy Compounds; Ethylmorphine; Female; Hypophysectomy; Male; Methylcholanthrene; Microsomes, Liver; Morphine; Phenobarbital; Rats; Rats, Inbred Strains; Sex Characteristics | 1984 |
Effects of the interferon inducing agents tilorone and polyriboinosinic acid . polyribocytidylic acid (poly IC) on the hepatic monooxygenase systems of pregnant and fetal rats.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fetus; Fluorenes; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Oxygenases; Phenobarbital; Poly I-C; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Tilorone | 1984 |
[Mechanisms of mixed-function oxidase system breakdown in the hepatic endoplasmic reticulum. The role of membrane phospholipid peroxidation].
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Lipid Peroxides; Liver; Male; Membrane Lipids; Methylcholanthrene; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Phospholipids; Rats | 1984 |
Metabolism and hepatotoxicity of the naturally occurring benzo[b]pyran precocene I.
Topics: Alanine Transaminase; Animals; Benzopyrans; Chromatography, High Pressure Liquid; In Vitro Techniques; Kidney; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism | 1984 |
Effects of pretreatment with toluene, phenobarbital and 3-methylcholantrene on the in vivo metabolism of toluene and on the excretion of hippuric acid in the rat.
Topics: Animals; Benzoates; Benzoic Acid; Chromatography, Gas; Chromatography, High Pressure Liquid; Enzyme Induction; Hippurates; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Toluene | 1984 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Methadyl Acetate; Methylcholanthrene; Mice; Mice, Inbred ICR; Necrosis; Phenobarbital; Time Factors | 1984 |
Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.
Topics: Animals; Bile; Cyclohexanes; Enzyme Induction; Glutathione; Kinetics; Male; Maleates; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Rats, Inbred Strains; Time Factors | 1984 |
[Effect of nomifensine on drug-metabolizing enzymes in single and multiple administrations].
Topics: Alcohol Oxidoreductases; Aniline Hydroxylase; Animals; Enzyme Induction; Ethylmorphine-N-Demethylase; Isoquinolines; Male; Methylcholanthrene; Microsomes, Liver; Nomifensine; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Immunoassay; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Peptide Fragments; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity.
Topics: Animals; Benzopyrene Hydroxylase; Cytochromes; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Structure-Activity Relationship | 1980 |
Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer.
Topics: Animals; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Rats | 1980 |
Induction of liver microsomal NADPH cytochrome C reductase and cytochrome P-450 by some new synthetic pyrethroids.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Insecticides; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Permethrin; Phenobarbital; Pyrethrins; Rats; Time Factors | 1980 |
Effects of some common inducers on the hepatic microsomal metabolism of androstenedione in rainbow trout with special reference to cytochrome P-450-dependent enzymes.
Topics: Androstenedione; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Salmonidae; Trout | 1980 |
Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin.
Topics: Animals; Bilirubin; Diet; Enzyme Induction; Ethoxyquin; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Phenobarbital; Quinolines; Rats | 1980 |
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; NADH Dehydrogenase; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats; Structure-Activity Relationship | 1980 |
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship | 1980 |
Sex difference in the O-dealkylation activity of 7-hydroxycoumarin O-alkyl derivatives in liver microsomes of rats.
Topics: Animals; Dealkylation; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Sex Factors; Spironolactone; Umbelliferones | 1980 |
Metabolic activation of mutagenic tryptophan pyrolysis products by rat liver microsomes.
Topics: Animals; Biotransformation; Cell Fractionation; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Activation; Hot Temperature; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Rats; Tryptophan | 1980 |
Effect of metal salts on UDPglucuronosyltransferase activity of various aglycones in rat liver microsomes in vitro.
Topics: Aminophenols; Animals; Biotransformation; Glucuronates; Glucuronosyltransferase; In Vitro Techniques; Male; Metals; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1980 |
Induction of different species of cytochrome P-450 by coplanar and noncoplanar isomers of hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Isomerism; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Molecular Conformation; Phenobarbital; Polychlorinated Biphenyls; Rats; Species Specificity | 1980 |
Effects of clophen A50, 3-methylcholanthrene, pregnenolone-16 alpha-carbonitrile, and phenobarbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout, Salmo gairdneri, of different age and sex.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Salmonidae; Sex Factors; Trout | 1980 |
Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule.
Topics: Animals; Fluorescent Antibody Technique; Liver; Male; Methylcholanthrene; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Effects of rubratoxin B on the hepatic monooxygenase system in phenobarbital and 3-methylcholanthrene induced male mice.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Mycotoxins; NADPH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Phenobarbital | 1980 |
Immunologically mediated toxicity.
Topics: Animals; Antibody Formation; Cytochrome P-450 Enzyme System; Enzyme Induction; Genes, MHC Class II; Humans; Hypersensitivity; Immunity; Immunoassay; Immunocompetence; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Toxicology | 1980 |
Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues.
Topics: Animals; Biotransformation; Bromobenzenes; Chloramphenicol; Furans; Humans; Liver; Lung; Methylcholanthrene; Microsomes; Models, Biological; Monocrotaline; Pharmaceutical Preparations; Phenobarbital; Pyrrolizidine Alkaloids; Terpenes | 1980 |
Aldrin epoxidation catalyzed by purified rat-liver cytochromes P-450 and P-448. High selectivity for cytochrome P-450.
Topics: Aldrin; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Epoxy Compounds; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats | 1980 |
Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats | 1980 |
Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution.
Topics: Animals; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Structure-Activity Relationship | 1981 |
A comparison of the cytochrome P-450 species induced by mirex and 3,4,5,3',4',5'-hexachlorobiphenyl in hepatic microsomes of the mouse.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Insecticides; Methylcholanthrene; Mice; Microsomes, Liver; Mirex; Phenobarbital; Polychlorinated Biphenyls | 1980 |
Hepatic microsomal enzyme induction by 2,2', 3,3', 4,4'- and 2,2', 3', 4,4', 5-hexachlorobiphenyl.
Topics: Animals; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Biphenyls; Rats | 1980 |
Metabolism of 7,12-dimethylbenz(a)anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene by rat liver and microsomes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cell Nucleus; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1981 |
A comparison of the effects of pretreatment with phenobarbitone and 3-methylcholanthrene on the metabolism of aflatoxin B1 by rat liver microsomes and isolated hepatocytes in vitro.
Topics: Aflatoxin B1; Aflatoxins; Animals; Cytochrome P-450 Enzyme System; DNA; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred F344 | 1981 |
Selective induction of two different molecular species of cytochrome P-450 by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Immune Sera; Immunoassay; Immunodiffusion; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1981 |
Apparent differential response of nuclear envelope cytochrome P-450 following phenobarbital induction arising from a preferential loss during gradient purification.
Topics: Animals; Cell Fractionation; Centrifugation, Density Gradient; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Enzyme Induction; Male; Methylcholanthrene; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Nuclear Envelope; Phenobarbital; Rats; Umbelliferones | 1981 |
Effects of inducers of drug metabolism enzymes on triglyceride and phospholipid biosynthesis.
Topics: Animals; Enzyme Induction; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Phospholipids; Polychlorinated Biphenyls; Rats; Triglycerides | 1981 |
Structure-activity study on induction of hepatic drug metabolizing enzymes by azo compounds.
Topics: Animals; Azo Compounds; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Structure-Activity Relationship | 1981 |
Stereochemical heterogeneity of hepatic UDP-glucuronosyltransferase activity in rat liver microsomes.
Topics: Animals; Glucuronosyltransferase; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Phenobarbital; Rats; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 1981 |
Electron-transport cytochrome P-450 system is involved in the microsomal metabolism of the carcinogen chromate.
Topics: Animals; Chromates; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Electron Transport; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Rats | 1981 |
Changes in toxic and antitumor properties of ftorafur by induction or inhibition of the microsomal enzymes activity.
Topics: Animals; Antineoplastic Agents; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Fluorouracil; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Tegafur | 1981 |
Covalent binding of polychlorinated biphenyls to proteins by reconstituted monooxygenase system containing cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Polychlorinated Biphenyls; Protein Binding; Proteins; Rabbits; Rats | 1981 |
Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Safrole; Substrate Specificity | 1981 |
Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver.
Topics: Aflatoxin B1; Aflatoxin M1; Aflatoxins; Animals; Biotransformation; Cell Nucleus; Cytochrome P-450 Enzyme System; DNA; Hydrogen-Ion Concentration; Kinetics; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats | 1982 |
Assessment of the cytochrome P-448 dependent liver enzyme system by a caffeine breath test.
Topics: Adult; Animals; Breath Tests; Caffeine; Carbon Dioxide; Carbon Radioisotopes; Cytochrome P-450 CYP1A2; Cytochromes; Dealkylation; Enzyme Induction; Humans; Liver; Liver Cirrhosis; Male; Methylcholanthrene; Middle Aged; Phenobarbital; Rats; Rats, Inbred Strains; Tobacco Use Disorder | 1981 |
Immunological analysis of the roles of two major types of cytochrome P-450 in mutagenesis of compounds isolated from pyrolysates.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Food Handling; Hot Temperature; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Mutation; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1982 |
Binding of polychlorinated biphenyls classified as either phenobarbitone-, 3-methylcholanthrene- or mixed-type inducers to cytosolic Ah receptor.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytosol; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Rats, Inbred Strains | 1982 |
Functional heterogeneity of UDP-glucuronosyltransferase activities in C57BL/6 and DBA/2 mice.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Intestinal Mucosa; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Morphine; Phenobarbital; Species Specificity; Substrate Specificity | 1982 |
Skin carcinogenesis and promoter binding characteristics in different mouse strains.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Croton Oil; Female; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Phenobarbital; Rodentia; Skin Neoplasms; Species Specificity; Time Factors | 1982 |
2,3,4,4'-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Enzyme Induction; Female; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Species Specificity; Thymus Gland | 1982 |
[Immunochemistry of catalytic activity of cytochrome P-450-LM2 from rat liver microsomes].
Topics: Animals; Antibodies; Antigen-Antibody Complex; Cytochrome P-450 Enzyme System; Immunodiffusion; Kinetics; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits | 1982 |
Return of drug-metabolizing systems to control levels after induction with 3-methylcholanthrene.
Topics: Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Glutathione Transferase; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Phenobarbital; Quinone Reductases; Rats | 1982 |
Enhancement of sulfanilamide N4-hydroxylase activity in kidney and liver microsomes of rats by pretreatment with 3-methylcholanthrene type-polychlorinated biphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrogen-Ion Concentration; Hydroxylation; In Vitro Techniques; Kidney; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Sulfanilamides | 1982 |
The binding to oxidised cytochromes P-450 and inhibition of mixed-function oxidases by aryl-substituted benzimidazoles and related compounds.
Topics: Aminopyrine N-Demethylase; Animals; Benzimidazoles; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism of the beta-carbolines harmine and harmol.
Topics: Alkaloids; Animals; Carbolines; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Harmine; Indoles; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital | 1983 |
[Reconstitution of membranous microsomal monooxygenase system during gel filtration on Sephadex LH-20].
Topics: Animals; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats | 1983 |
Evidence for hepatic formation, export and covalent binding of reactive naphthalene metabolites in extrahepatic tissues in vivo.
Topics: Animals; Binding Sites; Biological Transport; Cytochrome P-450 Enzyme System; Glutathione; Kidney; Liver; Lung; Male; Methylcholanthrene; Mice; Microsomes; Naphthalenes; Necrosis; Phenobarbital; Xylenes | 1983 |
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system.
Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone | 1983 |
Induction of hepatic microsomal cytochrome P-448-mediated oxidases by 3,3'-dichlorobenzidine in the rat.
Topics: 3,3'-Dichlorobenzidine; Animals; Aryl Hydrocarbon Hydroxylases; Benzidines; Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Selectivity of 1-phenylimidazole as a ligand for cytochrome P-450 and as an inhibitor of microsomal oxidation.
Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme System; Imidazoles; Ligands; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Reanalysis and clarification of the structures of alpha-naphthoflavone dihydrodiols formed by uninduced and induced rat liver microsomes from Charles River CD and Sprague-Dawley rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Flavonoids; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Species differences in cytochromes P-450 and epoxide hydrolase: comparisons of xenobiotic-induced hepatic microsomal polypeptides in hamsters and rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Species Specificity; Stilbenes | 1983 |
The effect of enzyme induction on the stereoselective metabolism of optically pure (-)1R,2R- and (+)1S,2S-dihydroxy-1,2-dihydrobenz-[a]anthracenes to vicinal 1,2-dihydrodiol 3,4-epoxides by rat liver microsomes.
Topics: Animals; Benz(a)Anthracenes; Chromatography, High Pressure Liquid; Enzyme Induction; Epoxy Compounds; Hydrolysis; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Models, Chemical; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism | 1983 |
Metabolism of alpha-naphthoflavone and beta-naphthoflavone by rat liver microsomes and highly purified reconstituted cytochrome P-450 systems.
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Flavonoids; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1983 |
Multiple effects and metabolism of alpha-naphthoflavone in induced and uninduced hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Flavonoids; Kinetics; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Rats; Species Specificity | 1983 |
Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation.
Topics: Aldrin; Animals; Cytochrome P-450 Enzyme System; Epoxy Compounds; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Effects of mixed-function oxidase inducers and inhibitors on cytochrome P-450 content, gel electrophoresis profiles, and 3-methylindole-induced lung toxicity in goats.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Goats; Indoles; Liver; Lung; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Proadifen; Skatole | 1983 |
Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole.
Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Female; Gene Expression Regulation; Kidney; Liver; Male; Methylcholanthrene; Mice; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole | 1983 |
Regioselectivity and stereoselectivity in the metabolism of trans-1,2-dihydroxy-1,2-dihydrobenz[a]anthracene by rat liver microsomes.
Topics: Animals; Benz(a)Anthracenes; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet; Stereoisomerism | 1983 |
Immunological and enzymatic comparison of hepatic cytochrome P-450 fractions from phenobarbital-, 3-methylcholanthrene-, beta-naphthoflavone- and 2,3,7,8- tetrachlorodibenzo-p-dioxin-treated rats.
Topics: Animals; Antibodies; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxins; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1983 |
Effects of DDT and dieldrin on intestinal glucose transport and brush border hydrolases. A comparison with phenobarbital and methylcholanthrene.
Topics: Animals; Biological Transport; DDT; Dieldrin; Enzyme Induction; Glucose; Hydrolases; Intestinal Absorption; Intestinal Mucosa; Male; Methylcholanthrene; Mice; Microvilli; Phenobarbital | 1983 |
Metabolism of benzo[c]phenanthrene by rat liver microsomes and by a purified monooxygenase system reconstituted with different isozymes of cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenanthrenes; Phenobarbital; Phenols; Rats; Stereoisomerism | 1983 |
Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Mice, Inbred C57BL; Nitrosamines; Phenobarbital; Porphyrins; Protoporphyrins | 1983 |
Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins).
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oxazines; Phenobarbital | 1983 |
Phenobarbital- and 3-methylcholanthrene-induced synthesis of two different molecular species of microsomal cytochrome P-450 in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Leucine; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Polyribosomes; Puromycin; Rats; Rats, Inbred Strains | 1983 |
3-Methylcholanthrene induces phenobarbital-induced cytochrome P-450 hemoprotein in fetal liver and not cytochrome P-448 hemoprotein induced in maternal liver of rats.
Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Female; Fetus; Hemeproteins; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1982 |
Activating enzymes: multiple monooxygenase forms with different substrate preferences as related to toxic effects.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrenes; Carcinogens; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Humans; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Oxygenases; Phenobarbital; Rabbits; Rats; Species Specificity; Stereoisomerism; Substrate Specificity | 1980 |
High-performance liquid chromatography technique for resolving multiple forms of hepatic membrane-bound cytochrome P-450.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Spectrum Analysis | 1980 |
Induction of O-deethylase activity as an index to exposure to coal-derived products and trace environmental pollutants.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aroclors; Coal; Cytochrome P-450 Enzyme System; Environmental Pollutants; Enzyme Induction; Female; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxygenases; Petroleum; Phenobarbital | 1981 |
Kinetic nature of the inhibition of a mixed-function oxidase by hydroxylamines; effect of the pretreatment of rats by inducing agents.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Binding, Competitive; Cytochrome P-450 Enzyme System; Hydroxylamines; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake--III. Induction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Proadifen; Rana pipiens; Salmonidae; Snakes; Species Specificity; Trout | 1982 |
Cytochrome P-450-dependent O-dealkylase activity in mammalian skin.
Topics: 7-Alkoxycoumarin O-Dealkylase; Adolescent; Adult; Animals; Cattle; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hexachlorobenzene; Humans; In Vitro Techniques; Kinetics; Liver; Macaca mulatta; Male; Methylcholanthrene; Mice; Mice, Hairless; Mice, Inbred A; Mice, Inbred BALB C; Oxygenases; Phenobarbital; Rabbits; Rats; Skin; Species Specificity | 1982 |
[Interrelation of cytochrome P-450 activity in the lymphocytes with their immune function].
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; Levamisole; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Nude; Phenobarbital; T-Lymphocytes | 1982 |
Characterization of rat-liver microsomal glutathione S-transferase activity.
Topics: Animals; Cytosol; Ethylmaleimide; Glutathione Transferase; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Peptide Hydrolases; Phenobarbital; Rats; Subcellular Fractions; Substrate Specificity | 1980 |
An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Female; Fluorescent Antibody Technique; Immunoenzyme Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Sex Factors | 1981 |
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Fluorescent Antibody Technique; Isoenzymes; Kidney; Liver; Lung; Male; Methylcholanthrene; Phenobarbital; Polychlorinated Dibenzodioxins; Rabbits | 1982 |
Metabolism of mutagenic amino-gamma-carbolines in tryptophan pyrolysates.
Topics: Animals; Benzopyrene Hydroxylase; Biotransformation; Carbolines; Cytochrome P-450 CYP1A2; Cytochromes; Gas Chromatography-Mass Spectrometry; Indoles; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens; Mutation; Phenobarbital; Rabbits; Rats; Salmonella typhimurium; Species Specificity | 1981 |
Effects of 3-methylcholanthrene, beta-naphthoflavone, and phenobarbital on the 3-methylcholanthrene-inducible isozyme of cytochrome P-450 within centrilobular, midzonal, and periportal hepatocytes.
Topics: Animals; Antigen-Antibody Complex; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Immune Sera; Isoenzymes; Male; Methylcholanthrene; Microscopy, Fluorescence; Microsomes, Liver; Organ Specificity; Phenobarbital; Rats | 1982 |
Cross-linking studies of the protein topography of rat liver microsomes.
Topics: Animals; Cross-Linking Reagents; Intracellular Membranes; Male; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Rats, Inbred Strains; Succinimides | 1982 |
The effect of chemical and physiological factors on the kinetics for product formation as it relates to enzyme activity and concentration, reaction time and to substrate adsorption and affinity.
Topics: Adenocarcinoma; Animals; Ascorbic Acid Deficiency; Enzyme Activation; Enzyme Inhibitors; Enzymes; Female; Guinea Pigs; Humans; Kinetics; Male; Mathematics; Methylcholanthrene; Mice; Microsomes, Liver; Models, Chemical; Phenobarbital; Rats; Starvation; Structure-Activity Relationship; Time Factors | 1982 |
Mixed-function amine oxidase of the rat hepatocyte nuclear envelope. Demonstration and effects of phenobarbital and 3-methylcholanthrene.
Topics: Animals; Enzyme Activation; Intracellular Membranes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nuclear Envelope; Oxidoreductases Acting on CH-NH Group Donors; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
The influence of various enzyme inducers on the microsomal metabolism of 7,8-benzoflavone.
Topics: Animals; Aroclors; Benzoflavones; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Possible functional coupling of hexose-6-phosphate dehydrogenase to microsomal electron transport system in rat kidney and liver.
Topics: Animals; Carbohydrate Dehydrogenases; Castration; Electron Transport; Fasting; Gonadal Steroid Hormones; Kidney; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Tissue Distribution | 1982 |
Heterogeneity of hepatic nicotine oxidase.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Isoenzymes; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Liver microsomal polypeptides from Fischer-344 rats affected by age, sex, and xenobiotic induction.
Topics: Age Factors; Animals; Cytochrome P-450 Enzyme System; Female; Male; Methylcholanthrene; Microsomes, Liver; Peptides; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sex Factors; Sexual Maturation | 1982 |
Metabolic activation of carbon tetrachloride: induction of cytochrome P-450 with phenobarbital or 3-methylcholanthrene and its effect on covalent binding.
Topics: Anaerobiosis; Animals; Biotransformation; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Effects of inducers and inhibitors of cytochrome P-450-linked monooxygenases on the toxicity, in vitro metabolism and in vivo irreversible binding of 2-methylnaphthalene in mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Naphthalenes; Oxidoreductases; Phenobarbital; Piperonyl Butoxide; Proadifen | 1982 |
Hepatic microsomal metabolism and macromolecular binding of the antioxidant, N-phenyl-2-naphthylamine.
Topics: 2-Naphthylamine; Animals; Antioxidants; Biotransformation; Drug Interactions; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Naphthalenes; Phenobarbital; Protein Binding; Rats; Species Specificity; Swine | 1982 |
Induction of hepatic microsomal propranolol N-desisopropylase activity by 3-methylcholanthrene and Sudan III.
Topics: Animals; Azo Compounds; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Propranolol; Rats; Rats, Inbred Strains | 1982 |
The relationship between the binding of 2-n-alkylbenzimidazoles to rat hepatic microsomal cytochrome P-450 and the inhibition of monooxygenation.
Topics: Animals; Benzimidazoles; Binding, Competitive; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1982 |
Studies on the trimethadione metabolism as a tool for the assessment of drug-metabolizing capacity using plasma and urine of rats pretreated with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Biotransformation; Creatinine; Glucaric Acid; Hydrogen-Ion Concentration; Liver; Male; Methylcholanthrene; Oxazoles; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Trimethadione | 1982 |
Inhibitors of hepatic mixed-function oxidases. 4. Effects of benzimidazole and related compounds on aryl hydrocarbon hydroxylase activity from phenobarbitone and 3-methylcholanthrene induced rats.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Enzyme Induction; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1982 |
Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls.
Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Stereoselective formation of bromobenzene glutathione conjugates.
Topics: Animals; Bile; Bromobenzenes; Chromatography, High Pressure Liquid; Glutathione; Magnetic Resonance Spectroscopy; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1982 |
The in vitro teratogenicity of cyclophosphamide in rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aroclors; Brain; Chlorodiphenyl (54% Chlorine); Culture Techniques; Cyclophosphamide; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Female; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnancy; Rats | 1982 |
Metabolism of tiaramide in vitro. I. Oxidative metabolism of tiaramide by human and rat liver microsomes.
Topics: Animals; Benzothiazoles; Humans; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperazines; Rats; Rats, Inbred Strains; Species Specificity | 1982 |
Effect of 1-m-tolueneazo-2-naphthol on hepatic drug metabolism. I. Induction of cytochrome P-448.
Topics: Animals; Azo Compounds; Coloring Agents; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.
Topics: Animals; Chrysenes; Cytochrome P-450 Enzyme System; Epoxy Compounds; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenanthrenes; Phenobarbital; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism | 1982 |
Differential sensitivity of hepatic microsomal aryl hydrocarbon hydroxylase to the inhibitory effect of SKF 525-A in rats of varying age, hormonal- and drug-induced status.
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Disorders of Sex Development; Enzyme Induction; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Sex Factors | 1982 |
Differential effects of 3-methylcholanthrene and phenobarbitone treatment on the oxidative metabolism of antipyrine in vitro by microsomal fractions of rat liver.
Topics: Animals; Antipyrine; Biotransformation; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics.
Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
Effects of phenobarbital and 3-methylcholanthrene on the in vivo distribution, metabolism and covalent binding of 4-ipomeanol in the rat; implications for target organ toxicity.
Topics: Animals; Biotransformation; Liver; Male; Methylcholanthrene; Organ Specificity; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Terpenes; Time Factors; Tissue Distribution | 1982 |
Comparative study on oxidation of aromatic compounds by rat liver and rabbit lung microsomes.
Topics: Animals; Energy Metabolism; Hydroxylation; Kinetics; Lung; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Phenobarbital; Rabbits; Rats | 1982 |
Studies on the substrate-binding sites of liver microsomal cytochrome P-448.
Topics: Animals; Benzphetamine; Binding Sites; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Fluorenes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry; Substrate Specificity | 1982 |
Polychlorinated naphthalenes as hepatic microsomal enzyme inducers in the immature male rat.
Topics: Animals; Aroclors; Drug Interactions; Enzyme Induction; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Naphthalenes; Phenobarbital; Rats | 1981 |
The suppressive effect of hepatic 9,000 x G supernatant fraction from 3-methylcholanthrene-treated rats on the mutagenic activity of 2-acetylaminofluorene.
Topics: 2-Acetylaminofluorene; Animals; Benzoflavones; Drug Synergism; Flavonoids; Liver; Male; Methylcholanthrene; Mutagens; Phenobarbital; Rats; Subcellular Fractions | 1980 |
Use of linoleic acid hydroperoxide in the determination of absolute spectra of membrane-bound cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Liver; Male; Membranes; Methylcholanthrene; Oxidation-Reduction; Phenobarbital; Rats | 1981 |
Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.
Topics: Animals; Biotransformation; Chemical Phenomena; Chemistry; Chrysenes; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Phenanthrenes; Phenobarbital; Rats | 1981 |
Effects of inducers and/or inhibitors on metabolism of lysergic acid diethylamide in rat liver microsomes.
Topics: Animals; Biotransformation; Carbon Monoxide; Enzyme Induction; Enzyme Inhibitors; In Vitro Techniques; Lysergic Acid Diethylamide; Methylcholanthrene; Microsomes, Liver; NAD; Oxygen Consumption; Phenobarbital; Proadifen; Rats | 1980 |
Metabolism of (-)-trans-(3R, 4R)-dihydroxy-3,4-dihydrochrysene to diol epoxides by liver microsomes.
Topics: Animals; Chemical Phenomena; Chemistry; Chrysenes; Epoxy Compounds; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenanthrenes; Phenobarbital; Rats; Stereoisomerism | 1981 |
Assays for metabolic alpha-hydroxylation of N'-nitrosonornicotine and N-nitrosopyrrolidine and the influence of modifying factors.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Cricetinae; Ethanol; Hydroxylation; Mesocricetus; Methylcholanthrene; Microsomes, Liver; N-Nitrosopyrrolidine; Nicotine; Nitrosamines; Phenobarbital; Rats | 1980 |
The influence of five monoxygenase inducers on liver cytosol estradiol receptor levels in the ovariectomized adult rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Castration; Cytosol; Enzyme Induction; Female; Liver; Methylcholanthrene; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Receptors, Estradiol; Receptors, Estrogen | 1981 |
Structural gene products of the murine Ah complex. Differences in ontogenesis and glucosamine incorporation between liver microsomal cytochromes P1-450 and P-448 induced by polycyclic aromatic compounds.
Topics: Animals; Borohydrides; Carbon Radioisotopes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Genes; Glucosamine; Iodine Radioisotopes; Kinetics; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Phosphates; Phosphorus Radioisotopes; Tritium | 1981 |
(-)Maackiain acetate specifically inhibits different forms of aryl hydrocarbon hydroxylase in rat and man.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrans; Female; Humans; Kidney; Kinetics; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Placenta; Pregnancy; Pterocarpans; Rats; Smoking | 1981 |
[Reactivity of the LM4 form of cytochrome P-450 from rabbit liver microsomes].
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits | 1981 |
Electroimmunochemical quantitation of cytochrome P-450, cytochrome P-448, and epoxide hydrolase in rat liver microsomes.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Epoxide Hydrolases; Female; Immunoelectrophoresis; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sex Factors; Species Specificity | 1981 |
Cimetidine: a specific inhibitor of hepatic aryl hydrocarbon hydroxylase (AHH) in the rat.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cimetidine; Guanidines; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Sleep | 1981 |
[Effect of inducers of mixed-function microsomal oxidases on the immune response of mice induced by heterologous erythrocytes].
Topics: Animals; Anti-Anxiety Agents; Antibody Formation; Benzodiazepines; Benzodiazepinones; Cytochrome P-450 Enzyme System; DDT; Diazepam; Enzyme Induction; Erythrocytes; Male; Methylcholanthrene; Mice; Phenobarbital; Phenytoin; Rifampin; Sheep | 1981 |
Metabolism of cyclopenta(cd)pyrene at the K-region by microsomes and a reconstituted cytochrome P-450 system from rat liver.
Topics: Animals; Cyclopentanes; Cytochrome P-450 Enzyme System; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pyrenes; Rats; Spectrophotometry, Ultraviolet | 1981 |
Specific labelling of microsomal proteins by reactive intermediates generated from 2-acetylaminofluorene in vitro.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytosol; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains | 1981 |
Changes in the matabolism of steroid hormones by the rat liver cytochrome P-450 system after induction with trans-stilbene oxide.
Topics: Androstenedione; Animals; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Stilbenes; Testosterone | 1981 |
Genetic regulation of bilirubin-UDP-glucuronosyltransferase induction by polycyclic aromatic compounds and phenobarbital in mice. Association with aryl hydrocarbon (benzo[a]pyrene) hydroxylase induction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Bilirubin; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Hexosyltransferases; Kinetics; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Species Specificity | 1981 |
Difference in the nature of induction of mixed-function oxidase systems of the rat liver among phenobarbital, DDT, 3-methylcholanthrene, and TCDD.
Topics: Animals; DDT; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1981 |
Differences in inducibility of particulate and cytosolic rat liver glutathione S-transferase activities.
Topics: Animals; Cytosol; Enzyme Induction; Glutathione Transferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats | 1981 |
Metabolism of N-(5-pyrrolidinopent-3-ynyl)-succinimide (BL 14) in rat liver preparations. Characterization of four oxidative reactions.
Topics: Alkynes; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pyrrolidinones; Rats; Rats, Inbred Strains; Thermodynamics | 1981 |
Magnetic circular dichroism studies of cytochrome P-450cam. Characterization of axial ligands of ferric and ferrous low-spin complexes.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Heme; Ligands; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Protein Conformation; Pseudomonas; Rabbits | 1981 |
Effect of inducers of drug-metabolizing enzymes on glutathione reductase and glutathione peroxidase in rat liver.
Topics: Animals; Cytosol; Enzyme Induction; Glutathione Peroxidase; Glutathione Reductase; Liver; Methylcholanthrene; Peroxidases; Phenobarbital; Rats; Stilbenes | 1981 |
Large differences in metabolic activation and inactivation of chemically closely related compounds: effects of pure enzymes and enzyme induction on the mutagenicity of the twelve monomethylated benz[a]anthracenes, 7,12-dimethylbenz[a]anthracene and benz[a
Topics: Animals; Aroclors; Benz(a)Anthracenes; Biotransformation; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Enzymes; Epoxide Hydrolases; Male; Methylcholanthrene; Mice; Mice, Inbred C3H; Mutagenicity Tests; Mutagens; Phenobarbital | 1981 |
Distribution and induction of cytochrome P-450 in rat liver nuclear envelope.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ferritins; Golgi Apparatus; Liver; Male; Methylcholanthrene; Nuclear Envelope; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Selective inactivation of cytochrome P-450 isozymes by suicide substrates.
Topics: Animals; Binding Sites; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity | 1981 |
Differences in the binding of 3-methylcholanthrene and phenobarbital to rat liver cytosolic and nuclear protein fractions.
Topics: Animals; Carrier Proteins; Cell Nucleus; Cytosol; Intracellular Signaling Peptides and Proteins; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Inhibition of azoreductase activity by antibodies against cytochromes P-450 and P-448.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADH, NADPH Oxidoreductases; Nitroreductases; Phenobarbital | 1981 |
The formation of carbamazepine epoxide by rat liver microsomes: an investigation of the biphasic kinetic profile.
Topics: Aging; Animals; Carbamazepine; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains | 1981 |
Changes in phospholipid methyltransferases and membrane microviscosity during induction of rat liver microsomal cytochrome P-450 by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cell Membrane; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylation; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Phenobarbital; Phospholipids; Rats; S-Adenosylmethionine; Temperature; Tritium; Viscosity | 1981 |
Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat.
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Drug Interactions; Enzyme Induction; Hydrocarbons, Chlorinated; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Studies of metabolism of tripamide, a new antihypertensive agent. II. Metabolism by the hepatic microsomal enzymes.
Topics: Aminopeptidases; Animals; Antibodies; Antihypertensive Agents; Carbon Monoxide; Cytochrome P-450 Enzyme System; Hydrolysis; Hydroxylation; In Vitro Techniques; Indoles; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Rats | 1981 |
Effects of pretreatment with SKF-525A, N-Methyl-2-thioimidazole, sodium phenobarbital, or methyl cholanthrene on ethylenethiourea-induced teratogenicity in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethylenethiourea; Female; Imidazoles; Methylcholanthrene; Phenobarbital; Pregnancy; Proadifen; Rats; Teratogens; Time Factors | 1981 |
Effects of microsomal induction and inhibition on styrene-induced acute hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biotransformation; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Serum Albumin; Styrenes; Sulfhydryl Compounds | 1981 |
The role of hepatic microsomal enzymes in the modulation of phencyclidine-induced toxicity.
Topics: Animals; Body Weight; Cysteine; Eating; Lethal Dose 50; Liver; Male; Maleates; Methylcholanthrene; Mice; Microsomes, Liver; Pentobarbital; Phencyclidine; Phenobarbital; Proadifen | 1981 |
Development of a novel method for measuring covalent binding and its application to investigations of bromobenzene hepatotoxicity.
Topics: Animals; Biopolymers; Biotransformation; Bromobenzenes; Liver; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats | 1981 |
Biotransformation of bromobenzene to reactive metabolites by isolated hepatocytes.
Topics: Animals; Biotransformation; Bromobenzenes; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Rats; Structure-Activity Relationship | 1981 |
Production of carbon monoxide by sonication of medium containing glycerol. Effect on cytochrome P-450 reconstituted systems.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Glycerol; Hemoglobins; Humans; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sonication; Spectrophotometry | 1981 |
Formation of irreversible protein-binding metabolites during microsomal metabolism of 14C-bromobenzene and 14C-bromophenol.
Topics: Animals; Biotransformation; Bromobenzenes; Carbon Radioisotopes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenols; Protein Binding; Proteins; Rats; Rats, Inbred Strains | 1981 |
Regio- and stereoselectivity of hepatic cytochrome P-450 toward polycyclic aromatic hydrocarbon substrates.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polycyclic Compounds; Rats; Stereoisomerism; Substrate Specificity | 1981 |
The cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls.
Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Fungicides, Industrial; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Further characterization and applications of the 4-chlorobiphenyl hydroxylase assay.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Substrate Specificity | 1981 |
The mechanism of the reductive dehalogenation of polyhalogenated compounds by microsomal cytochrome P450.
Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Hydrocarbons, Halogenated; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Reactive intermediates of 2-acetylaminofluorene metabolism in vitro covalently label specific rat liver microsomal proteins.
Topics: 2-Acetylaminofluorene; Animals; Carbon Radioisotopes; Kinetics; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats | 1981 |
Effects of ethynyl estradiol on liver microsomal mixed function oxygenase activity in male rats.
Topics: Animals; Ethinyl Estradiol; Female; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Phenobarbital; Rats | 1980 |
Studies on the synthesis of cytochrome P-450 and cytochrome P-448 in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Liver; Methylcholanthrene; Molecular Weight; Phenobarbital; Plants; Protein Biosynthesis; Rats; Triticum | 1980 |
Estrogen-2-hydroxylase in the rat. Distribution and response to hormonal manipulation.
Topics: Animals; Castration; Catechol O-Methyltransferase; Cytochrome P-450 CYP1A1; Enzyme Induction; Estrogens; Female; Hormones; Male; Methylcholanthrene; Phenobarbital; Rats; Steroid Hydroxylases; Thyroidectomy; Thyroxine | 1980 |
Enhanced biotransformation of nitrofurantoin in rats after induction with 3-methylcholanthrene or beta-naphthoflavone.
Topics: Aerobiosis; Animals; beta-Naphthoflavone; Biotransformation; Enzyme Induction; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Nitrofurantoin; Phenobarbital; Rats | 1980 |
The interaction of aliphatic nitro compounds with the liver microsomal monooxygenase system.
Topics: Animals; Formaldehyde; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nitrites; Nitro Compounds; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1980 |
Denitrosation of N-nitrosomorpholine by liver microsomes; possible role of cytochrome P-450.
Topics: Aminoacetonitrile; Animals; Benzoflavones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Inactivation, Metabolic; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morpholines; Nitrites; Nitrosamines; Phenobarbital; Rats | 1980 |
Correlation between changes in enzymatic activities and induction of different forms of rat liver microsomal cytochrome P-450 after phenobarbital-, 3-methylcholanthrene- and 16 alpha-cyanopregnenolone treatment.
Topics: Androstane-3,17-diol; Androstenedione; Animals; Benzopyrenes; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Organ Size; Phenobarbital; Pregnenolone; Rats | 1980 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Metyrapone - reduced cytochrome P-450 complex: a specific method for the determination of the phenobarbital inducible form of rat hepatic microsomal cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1980 |
Enhancement by cyanide of aniline p-hydroxylation activity in rat liver microsomes.
Topics: 2,2'-Dipyridyl; Acetone; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cyanides; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Potassium Cyanide; Rats | 1980 |
Species differences in stimulation of intestinal and hepatic microsomal mixed-function oxidase enzymes.
Topics: Animals; Enzyme Induction; Guinea Pigs; Intestine, Small; Male; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rabbits; Rats; Species Specificity | 1980 |
Microsome-mediated covalent binding of 1,2-dichloroethane to lung microsomal protein and salmon sperm DNA.
Topics: Animals; Binding, Competitive; Biotransformation; Carcinogens; Cytosol; DNA; Ethylene Dichlorides; Fishes; Hydrocarbons, Chlorinated; Lung; Male; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats; Spermatozoa | 1980 |
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole | 1980 |
Inducibility of drug-metabolizing enzymes in the rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rifampin; Skin | 1980 |
Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic compounds.
Topics: Alleles; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; beta-Naphthoflavone; Carboxy-Lyases; Dioxins; Enzyme Induction; Flavonoids; Kidney; Liver; Methylcholanthrene; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phenobarbital; Polychlorinated Dibenzodioxins; Protein Kinases; Species Specificity | 1980 |
Interaction of the tobacco-specific nitrosamines, methylethylnitrosamine and N-nitrosonornicotine, with DNA and guanosine.
Topics: Animals; Benzylamines; Dimethylnitrosamine; DNA; Guanosine; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Nicotiana; Nicotine; Nitrosamines; Phenobarbital; Plants, Toxic; Rats | 1980 |
Comparison of ratios of covalent binding to total metabolism of the pulmonary toxin, 4-ipomeanol, in vitro in pulmonary and hepatic microsomes, and the effects of pretreatments with phenobarbital or 3-methylcholanthrene.
Topics: Alkylating Agents; Animals; Biotransformation; Furans; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Rats; Terpenes | 1980 |
Inactivation of hepatic cytochrome P-450 by allenic substrates.
Topics: Alkadienes; Animals; Cytochrome P-450 Enzyme Inhibitors; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats | 1980 |
Antipyrine metabolism in the rat by three hepatic monooxygenases.
Topics: Animals; Antipyrine; Drug Stability; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Sex Factors; Time Factors | 1980 |
Effect of mercuric chloride on microsomal enzyme system in mouse liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; In Vitro Techniques; Male; Mercury; Methylcholanthrene; Mice; Mice, Inbred C3H; Microsomes, Liver; Nitroanisole O-Demethylase; Phenobarbital; Proteins | 1980 |
[Effect of the combined and separate administration of phenobarbital and 3-methylcholanthrene on liver benzopyrene hydroxylases in "sensitive" and "resistant" inbred mice].
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Drug Synergism; Enzyme Induction; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital | 1980 |
Pancreatic metabolism of benzo(a)pyrene in vitro and in vivo in the Long-Evans rat.
Topics: Animals; Benzopyrenes; Bile; DNA; In Vitro Techniques; Liver; Male; Methylcholanthrene; Pancreas; Phenobarbital; Rats | 1980 |
Activation of hepatic microsomal biphenyl 2-hydroxylation by corticosteroids.
Topics: Adrenal Cortex Hormones; Animals; Betamethasone; Biotransformation; Biphenyl Compounds; Gonadal Steroid Hormones; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Enzymic formation of dehydrogenated and hydroxylated metabolites from lysergic acid diethylamide by rat liver microsomes.
Topics: Anaerobiosis; Animals; Biotransformation; Hydroxylation; In Vitro Techniques; Lysergic Acid Diethylamide; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Benzo(a)pyrene metabolism by purified forms of rabbit liver microsomal cytochrome P-450, cytochrome b5 and epoxide hydrase in reconstituted phospholipid vesicles.
Topics: Animals; Benzopyrenes; Biotransformation; Cell-Free System; Cytochrome P-450 Enzyme System; Cytochromes; Epoxide Hydrolases; Kinetics; Liposomes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Stereoisomerism | 1980 |
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein.
Topics: Animals; Body Weight; Dietary Proteins; Enzyme Induction; Liver; Male; Methylcholanthrene; Organ Size; Pharmaceutical Preparations; Phenobarbital; Rats | 1980 |
Multiple forms of cytochrome P-450 purified from liver microsomes of phenobarbital- and 3-methylcholanthrene-pretreated rabbits. I. Resolution, purificaton, and molecular properties.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rabbits; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1980 |
Genetic expression of aflatoxin B1 metabolism: effects of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the metabolism of aflatoxins B1 and B2 by various inbred strains of mice.
Topics: Aflatoxins; Animals; Dioxins; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Species Specificity | 1980 |
Ethanol-inducible liver cytochrome P-450 in the rat: relative specificity for ethanol oxidation activity in vitro.
Topics: Acetaldehyde; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Female; In Vitro Techniques; Liver; Methylcholanthrene; Oxidation-Reduction; Phenobarbital; Rats; Substrate Specificity | 1980 |
Additive effects of inducers and fasting on acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Enzyme Induction; Fasting; Glutathione; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1980 |
Inhibition of cytochrome P-448 mixed function oxidase activity following administration of 9-hydroxyellipticine to rats.
Topics: Alkaloids; Aniline Compounds; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1980 |
Benzo[a]pyrene metabolism and macromolecular binding in strains of Ah responsive and Ah non-response mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; DNA; Enzyme Induction; In Vitro Techniques; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Proteins; Species Specificity | 1980 |
Metabolism of dihalomethanes to carbon monoxide. IV. Studies in isolated rat hepatocytes.
Topics: Animals; Carbon Monoxide; Hydrocarbons, Halogenated; In Vitro Techniques; Kinetics; Liver; Male; Methane; Methylcholanthrene; Phenobarbital; Proadifen; Rats | 1980 |
Characterization of the cytochrome P-450 species induced by trans-stilbene oxide.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Stilbenes; Substrate Specificity | 1980 |
Differential effects of cytochrome P450-inducers on promutagen activation capabilities and enzymatic activities of S-9 from rat liver.
Topics: Animals; Aroclors; Chemical Phenomena; Chemistry; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Liver; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Phenobarbital; Rats | 1980 |
Effects of induction on R- and S-warfarin and metabolite concentrations in rat plasma.
Topics: Animals; Blood Coagulation; Enzyme Induction; Half-Life; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Stereoisomerism; Warfarin | 1980 |
The utility of the microsomal 4-chlorobiphenyl hydroxylase enzyme assay in distinguishing between phenobarbitone- and 3-methylcholanthrene-induced microsomal monooxygenases.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chlorophenols; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Substrate Specificity | 1980 |
Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Kinetics; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
The in vitro formation of glutathione conjugates with the microsomally activated pulmonary bronchiolar aklylating agent and cytotoxin, 4-ipomeanol.
Topics: Alkylating Agents; Animals; Furans; Glutathione; Glutathione Transferase; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Terpenes | 1980 |
Metabolism of trichloroethylene.
Topics: Animals; Chloral Hydrate; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Proteins; Rats; Subcellular Fractions; Trichloroacetic Acid; Trichloroethylene | 1980 |
Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes.
Topics: Animals; Antigen-Antibody Reactions; Cytochrome P-450 Enzyme System; Electron Transport; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats | 1980 |
Irreversible binding of isolated benzo[a]pyrene metabolites to specific rat liver microsomal proteins.
Topics: Animals; Benzopyrenes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Time Factors | 1980 |
Effect of cadmium on phenobarbital and polycyclic hydrocarbon-induced alterations in hepatic microsomal monooxygenase activity in the rat.
Topics: Animals; Benzopyrenes; Cadmium; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Sex Factors | 1980 |
[Reciprocal action between caffeine, other stimulants and drugs].
Topics: Analgesics; Animals; Barbiturates; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Ethanol; Humans; Methylcholanthrene; Nicotinic Acids; Phenobarbital; Smoking; Theobromine; Xanthines | 1980 |
Effect of 3-methylcholanthrene administration on hepatic ribonucleic acid polymerase activities.
Topics: Animals; Cell Nucleolus; Cell Nucleus; DNA-Directed RNA Polymerases; Enzyme Induction; Liver; Male; Methylcholanthrene; Phenobarbital; Rats | 1981 |
Effect of cytochrome P450 inducers on liver microsomal metabolism of tetrachlorobiphenyls in rats, guinea pigs and hamsters.
Topics: Animals; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Wistar; Species Specificity | 1995 |
Differential induction of UDP-glucuronosyltransferase activity and gene expression in rat liver.
Topics: Animals; Antioxidants; DNA Probes; Enzyme Induction; Gene Expression; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Indoles; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nucleic Acid Hybridization; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.
Topics: Animals; Carbolines; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Microsomes; Mutagenicity Tests; Mutagens; Phenobarbital; Quinolines; Smoking | 1995 |
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone | 1995 |
Effect of age and sex on the inducibility of hepatic microsomal 4-nitrophenol UDP-glucuronyltransferase activity in rats.
Topics: Aging; Animals; Dexamethasone; Enzyme Induction; Female; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1995 |
Dose-dependent induction of the microsomal monooxygenase system by phenobarbital and 3-methylcholanthrene in the ad libitum and calorie-restricted female rat.
Topics: Animals; Antibodies, Monoclonal; Body Weight; Cytochrome P-450 Enzyme System; Diet; Dose-Response Relationship, Drug; Energy Intake; Enzyme Induction; Female; Immunophenotyping; Liver; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred F344 | 1995 |
Induction of CYP2B1 mediated pentoxyresorufin O-dealkylase activity in different species, sex and tissue by prototype 2B1-inducers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Barbital; Carcinogens; Cricetinae; Cyclophosphamide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Dimethylnitrosamine; Enzyme Induction; Female; Ketones; Kidney; Liver; Lung; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred Strains; Phenobarbital; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity; Steroid Hydroxylases; Substrate Specificity | 1995 |
[Biotransformation processes in fertile hen's eggs. 1. Metabolic transformation of 7-ethoxycoumarin].
Topics: Animals; Biotransformation; Chick Embryo; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronates; Methylcholanthrene; Ovalbumin; Phenobarbital; Sulfates | 1995 |
[Effect of aflatoxin B1 on monooxygenase activity in liver microsomes exposed to cytochrome P-450].
Topics: 7-Alkoxycoumarin O-Dealkylase; Aflatoxin B1; Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar | 1994 |
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Enzyme Induction; Glucuronosyltransferase; Homeostasis; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1995 |
Constitutive and inducible expression of drug metabolizing enzymes in cultured human keratinocytes.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Cells, Cultured; Cytochrome P-450 Enzyme System; DNA Primers; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Humans; Immunoblotting; Keratinocytes; Methylcholanthrene; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Wistar; Tretinoin | 1995 |
[A selective decrease in cytochrome P450 in the liver microsomes of male rats following phenobarbital and 3-methylcholanthrene induction and acute tetrachloromethane poisoning].
Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar | 1993 |
Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Liver; Liver Neoplasms, Experimental; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Testosterone; Tumor Cells, Cultured; Xenobiotics | 1994 |
Effects of partial hepatectomy, phenobarbital and 3-methylcholanthrene on kinetic parameters of glucose-6-phosphate and phosphogluconate dehydrogenase in situ in periportal, intermediate and pericentral zones of rat liver lobules.
Topics: Animals; Female; Frozen Sections; Glucosephosphate Dehydrogenase; Hepatectomy; Histocytochemistry; Liver; Methylcholanthrene; Phenobarbital; Phosphogluconate Dehydrogenase; Portal Vein; Rats; Rats, Wistar; Tissue Distribution | 1995 |
Differential effect of cytokines on the phenobarbital or 3-methylcholanthrene induction of P450 mediated monooxygenase activity in cultured rat hepatocytes.
Topics: Animals; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Cytokines; Drug Interactions; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred F344 | 1995 |
Detection of 1-acetamino-3-(1-naphthyloxy)-2-propanol as a new metabolite of propranolol.
Topics: Acetamides; Aged; Animals; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Methylcholanthrene; Middle Aged; Oxidation-Reduction; Phenobarbital; Propanolamines; Propranolol; Rats; Rats, Wistar | 1994 |
Cytochrome P450 activities in pure and co-cultured rat hepatocytes. Effects of model inducers.
Topics: Animals; Cell Line; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Epithelium; Haplorhini; Kidney; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Testosterone | 1994 |
Studies on the ontogeny of goat hepatic cytochrome P-450-associated O-dealkylase activities using monoclonal antibodies: comparison to adult lung activity.
Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Goats; Isoenzymes; Liver; Lung; Methylcholanthrene; Oxidoreductases; Phenobarbital | 1993 |
Chemical and enzyme-catalysed synthesis of quinoline arene hydrates.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Hydroxylation; Hydroxyquinolines; Magnetic Resonance Spectroscopy; Methylcholanthrene; Microsomes, Liver; Molecular Structure; Mucorales; Phenobarbital; Quinolines | 1994 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
[Induction of cytochromes P-4501A and 2B in various rat organs, subjected to hexachlorobenzene and aroclor 1254].
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Isoenzymes; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes; Phenobarbital; Rats; Rats, Wistar | 1994 |
Modulation of cytochrome P-450 induction by long-term food restriction in male rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Energy Intake; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Time Factors | 1994 |
Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues.
Topics: Aging; Animals; Animals, Newborn; Aorta; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Ductus Arteriosus; Enzyme Induction; Female; Immunohistochemistry; Liver; Lung; Methylcholanthrene; Microscopy, Immunoelectron; Muscle Contraction; Muscle, Smooth, Vascular; Oxygen; Oxygenases; Phenobarbital; Pregnancy; Sheep | 1994 |
Metabolism of nitrosamines and aflatoxin B1 by hamster liver CYP2A enzymes.
Topics: Aflatoxin B1; Animals; Blotting, Western; Coumarins; Cricetinae; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Female; Kinetics; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Phenobarbital; Pyrazoles; Steroid Hydroxylases | 1994 |
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats.
Topics: Administration, Oral; Animals; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1994 |
Different drug metabolizing capacities in cultured periportal and pericentral hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Biphenyl Compounds; Cells, Cultured; Glutathione Transferase; Harmine; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Pyrazoles; Rats; Rats, Sprague-Dawley; Xenobiotics | 1994 |
Interaction of cimetidine with cytochrome P450 and effect on mixed-function oxidase activities of liver microsomes.
Topics: Animals; Cimetidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar | 1993 |
Glucuronidation and isomerization of all-trans- and 13-cis-retinoic acid by liver microsomes of phenobarbital- or 3-methylcholanthrene-treated rats.
Topics: Animals; Humans; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Tretinoin | 1994 |
DNA adduct formation of hepatocarcinogenic aromatic amines in rat liver: effect of cytochrome P450 inducers.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Imidazoles; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Rats; Rats, Inbred F344 | 1994 |
Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.
Topics: Aflatoxin B1; Aldehyde Reductase; Animals; Anticarcinogenic Agents; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Clofibrate; Enzyme Induction; Ethoxyquin; Glutathione Transferase; Isoenzymes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred F344; Tissue Distribution; Xenobiotics | 1994 |
Differential induction of glutathione S-transferase in rat aorta versus liver.
Topics: Animals; Aorta; Butylated Hydroxytoluene; Enzyme Induction; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Wistar | 1994 |
Increase in liver microsomal glutathione S-transferase activity by phenobarbital treatment of rats. Possible involvement of oxidative activation via cytochrome P450.
Topics: Amitrole; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Ethylmaleimide; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Isoniazid; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Scoparone O-demethylase assay is not useful to differentiate the effects of model inducers of cytochrome P-450 in rabbit and guinea pig liver.
Topics: Animals; Biomarkers; Biotransformation; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Guinea Pigs; Humans; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, O-Demethylating; Phenobarbital; Rabbits; Rats; Rats, Wistar; Species Specificity | 1993 |
UDP glucuronosyltransferase gene expression is involved in the stimulation of ascorbic acid biosynthesis by xenobiotics in rats.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Base Sequence; Blotting, Northern; Body Weight; Chloramphenicol; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Injections, Intraperitoneal; Liver; Methylcholanthrene; Molecular Sequence Data; Nitrophenols; Organ Size; Phenobarbital; Polymerase Chain Reaction; Rats; Rats, Gunn; Rats, Inbred Strains; RNA, Messenger; Time Factors; Xenobiotics | 1993 |
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; Coumarins; Dose-Response Relationship, Drug; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Administration of high doses of human recombinant interleukin-2 decreases the expression of several cytochromes P-450 in the rat.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes b5; Drug Interactions; Humans; Interleukin-2; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Organ Size; Phenobarbital; Rats; Rats, Sprague-Dawley; Recombinant Proteins | 1994 |
Xenobiotic-modulated expression of hepatic glutathione S-transferase genes in primary rat hepatocyte culture.
Topics: Animals; Base Sequence; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation; Glutathione Transferase; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Xenobiotics | 1993 |
Trimethylamine N-oxygenation and N-demethylation in rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme System; Ethanol; Male; Methylamines; Methylation; Methylcholanthrene; Microsomes, Liver; Oxygen; Oxygenases; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Further differentiation of 2'- and 4'-chloroflavones as inducers of hepatic microsomal monooxygenases in rats.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, O-Demethylating; Phenobarbital; Rats; Rats, Wistar | 1993 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma, Hepatocellular; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Kinetics; Liver Neoplasms; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Differential induction of glutathione S-transferase subunits by phenobarbital, 3-methylcholanthrene and ethoxyquin in rat liver and kidney.
Topics: Animals; Enzyme Induction; Ethoxyquin; Glutathione Transferase; Kidney; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Sprague-Dawley | 1993 |
Effects of hepatic enzyme inducers and mitogens on experimental Tyzzer's disease in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bacillaceae Infections; Bacillus; Body Weight; Enzyme Induction; Ethylene Dibromide; Female; Lead; Liver; Methylcholanthrene; Mitogens; Nitrates; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Reference Values | 1993 |
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
Topics: Cells, Cultured; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Liver; Methylcholanthrene; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1993 |
Phase I and phase II xenobiotic reactions and metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in aggregating liver cell cultures.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aging; Animals; Cells, Cultured; Dimethyl Sulfoxide; Drug Synergism; Enzyme Induction; Glutathione Transferase; Liver; Methylcholanthrene; Phenobarbital; Quinoxalines; Rats; Xenobiotics | 1993 |
Crude liver membrane fractions and extracellular matrix components as substrata regulate differentially the preservation and inducibility of cytochrome P-450 isoenzymes in cultured rat hepatocytes.
Topics: Animals; Cell Membrane; Cells, Cultured; Collagen; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix Proteins; Fibronectins; Isoenzymes; Kinetics; Laminin; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Sprague-Dawley; Substrate Specificity; Time Factors | 1993 |
Induction of Schistosoma mansoni glutathione S-transferase by xenobiotics.
Topics: Animals; Butylated Hydroxyanisole; Enzyme Induction; Female; Gene Expression; Glutathione Transferase; Methylcholanthrene; Mice; Phenobarbital; RNA, Messenger; Schistosoma mansoni; Xenobiotics | 1993 |
Metabolism of 2-acetylaminofluorene. I. Metabolism in vitro of 2-acetylaminofluorene and 2-acetylaminofluoren-9-one by hepatic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cytosol; Female; Hydroxylation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1993 |
The hepatic metabolism of two methylquinolines.
Topics: Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Quinolines; Rats; Rats, Sprague-Dawley | 1993 |
L-gulono-gamma-lactone oxidase is not induced in rats by xenobiotics stimulating L-ascorbic acid biosynthesis.
Topics: Animals; Ascorbic Acid; Blotting, Northern; Cytochrome P-450 Enzyme System; L-Gulonolactone Oxidase; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Sugar Alcohol Dehydrogenases; Tissue Distribution; Xenobiotics | 1993 |
Effects of phenobarbital, dexamethasone, and 3-methylcholanthrene administration on the metabolism of 17 beta-estradiol by liver microsomes from female rats.
Topics: Aging; Animals; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Estradiol; Female; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1996 |
Purification and characterization of a cytochrome P450 isozyme catalyzing lanosterol 14 alpha-demethylation (P45014DM) in hamster liver.
Topics: Animals; Catalysis; Chemical Phenomena; Chemistry, Physical; Cholesterol; Chromatography; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Immunoblotting; Lanosterol; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Spectrophotometry; Sterol 14-Demethylase | 1995 |
Similarities and differences in the glucuronidation of estradiol and estrone by UDP-glucuronosyltransferase in liver microsomes from male and female rats.
Topics: Animals; Dexamethasone; Estradiol; Estrone; Female; Glucuronates; Glucuronosyltransferase; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Rats; Substrate Specificity; Testosterone | 1996 |
Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.
Topics: Aldehyde Reductase; Animals; Antioxidants; Barbiturates; Butylated Hydroxyanisole; Carcinogens; Enzyme Induction; Ethoxyquin; Liver; Methylcholanthrene; Oxidation-Reduction; Phenobarbital; Pyrazines; Rats; Thiones; Thiophenes | 1996 |
A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture.
Topics: Animals; Cells, Cultured; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes | 1996 |
Interaction of 2,4,4'-trichloro-2'-hydroxydiphenyl ether with microsomal cytochrome P450-dependent monooxygenases in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Blotting, Western; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluorometry; GABA Modulators; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Software; Steroid Hydroxylases; Triclosan | 1996 |
Perifusion of co-cultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro.
Topics: Animals; Benz(a)Anthracenes; Biotransformation; Cell Culture Techniques; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytotoxins; Diffusion Chambers, Culture; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley | 1996 |
Effects of feeding Artemisia filifolia and Helenium flexuosum on rabbit cytochrome P450 isozymes.
Topics: Animal Feed; Animals; Artemisia; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Plants, Medicinal; Plants, Toxic; Proadifen; Rabbits | 1996 |
Mechanism-based inactivation of hepatic ethoxyresorufin O-dealkylation activity by naturally occurring coumarins.
Topics: Animals; Anticoagulants; Anticonvulsants; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 CYP1A1; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Furocoumarins; Heme; Humans; Hypnotics and Sedatives; Methylcholanthrene; Mice; Mice, Inbred SENCAR; Microsomes, Liver; Phenobarbital; Plant Extracts; Radioligand Assay | 1996 |
Involvement of cytochrome b5 in the metabolism of tetrachlorobiphenyls catalyzed by CYP2B1 and CYP1A1.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Cytochromes b5; Hydroxylation; Immunoglobulin G; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Wistar | 1996 |
The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats.
Topics: Animals; Bile; Biliary Tract; Enzyme Induction; Femoral Vein; Injections, Intravenous; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Ouabain; Phenobarbital; Portal Vein; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley | 1995 |
Phenobarbital-type P-450 inducers protect rats against metaldehyde toxicity.
Topics: Acetaldehyde; Administration, Oral; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Dichlorodiphenyldichloroethane; Enzyme Induction; Hydrolysis; Hypnotics and Sedatives; Insecticides; Liver; Male; Methylcholanthrene; Molluscacides; Phenobarbital; Rats; Rats, Sprague-Dawley | 1996 |
Glucuronidation of all-trans-retinoic acid and 5,6-epoxy-all-trans-retinoic acid. Activation of rat liver microsomal UDP-glucuronosyltransferase activity by alamethicin.
Topics: Affinity Labels; Alamethicin; Animals; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Tretinoin | 1997 |
The role of microsomal beta-glucuronidase in ascorbic acid biosynthesis stimulated by xenobiotics in rats.
Topics: Animals; Ascorbic Acid; Blotting, Northern; Glucuronidase; Heterozygote; Homozygote; Hyperbilirubinemia; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Xenobiotics | 1997 |
Islet antioxidant and second phase enzyme levels following CYP1A, CYP2E, CYP2B and CYP4A induction.
Topics: Acetone; Animals; Antioxidants; Catalase; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Islets of Langerhans; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Superoxide Dismutase | 1997 |
Regulation of the major detoxication functions by phenobarbital and 3-methylcholanthrene in co-cultures of rat hepatocytes and liver epithelial cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Coculture Techniques; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Epithelial Cells; Epithelium; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Phenobarbital; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid Hydroxylases | 1997 |
Characterization of 1-hydroxypyrene as a novel marker substrate of 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase(s).
Topics: Acetone; Animals; Carcinogens; Chromatography, High Pressure Liquid; Creosote; Enzyme Induction; Enzyme Inhibitors; Glucuronates; Glucuronosyltransferase; Magnetic Resonance Spectroscopy; Male; Methylcholanthrene; Methylenebis(chloroaniline); Microsomes, Liver; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Pyrazoles; Pyrenes; Rats; Rats, Wistar; Substrate Specificity | 1997 |
Induced drug resistance inhibits selection of initiated cells and cancer development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Liver; Liver Regeneration; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Rats, Wistar | 1997 |
Effects of phenobarbital and 3-methylcholanthrene induction on the formation of three glucuronide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, NNK.
Topics: Animals; Biotransformation; Carcinogens; Cells, Cultured; Glucuronates; Hemoglobins; Hydroxylation; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Microsomes, Liver; Nitrosamines; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred F344 | 1997 |
Enhancing effects of phenobarbital and 3-methylcholanthrene on GST-P-positive liver cell foci development in a new medium-term rat liver bioassay using D-galactosamine.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Body Weight; Carcinogens; Diet; Diethylnitrosamine; Galactosamine; Glutathione Transferase; Injections, Intraperitoneal; Liver; Liver Neoplasms; Liver Regeneration; Male; Methylcholanthrene; Organ Size; Phenobarbital; Rats; Rats, Inbred F344 | 1997 |
Effect of phenobarbital, 3-methylcholanthrene, and chloramphenicol pretreatment on the pharmacokinetics and pharmacodynamics of azosemide in rats.
Topics: Animals; Area Under Curve; Blood Proteins; Chloramphenicol; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diuretics; Enzyme Induction; Enzyme Inhibitors; Half-Life; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; Sulfanilamides | 1997 |
Stereoselective N-demethylation of chlorpheniramine by rat-liver microsomes and the involvement of cytochrome P450 isozymes.
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Chlorpheniramine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Histamine H1 Antagonists; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1997 |
Effect of inducers on hepatic microsomal mixed function oxidase system of male rats during food restriction.
Topics: Animals; Enzyme Induction; Food Deprivation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar | 1997 |
Metabolism of 14C-labelled 5-nitro-1,2,4-triazol-3-one by rat liver microsomes--evidence for the participation of cytochrome P-450.
Topics: Animals; Carbon Radioisotopes; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Fungal Proteins; Glucocorticoids; Male; Methylcholanthrene; Microsomes, Liver; Nitro Compounds; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Triazoles | 1997 |
Phenobarbital and 3-methylcholanthrene treatment alters phase I and II enzymes and the sensitivity of the rat colon to the carcinogenic activity of azoxymethane.
Topics: Animals; Azoxymethane; Biotransformation; Carcinogens; Colon; Enzyme Induction; GABA Modulators; Glucosyltransferases; Glutathione Transferase; Intestinal Mucosa; Male; Methylcholanthrene; NADH Dehydrogenase; Phenobarbital; Rats; Rats, Sprague-Dawley | 1997 |
Cloning and characterization of Syrian hamster testosterone 7 alpha-hydroxylase, CYP2A9.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cloning, Molecular; COS Cells; Cricetinae; DNA, Complementary; Female; Gene Expression; Kidney; Liver; Male; Mesocricetus; Methylcholanthrene; Molecular Sequence Data; Molecular Weight; Phenobarbital; Polymerase Chain Reaction; RNA, Messenger; Steroid Hydroxylases; Testosterone; Transfection | 1998 |
Pharmacokinetic changes of M1, M2, M3 and M4 after intravenous administration of a new anthracycline, DA-125, to rats pretreated with phenobarbital, 3-methylcholanthrene, chloramphenicol, or SKF-525A.
Topics: Animals; Anthracyclines; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Carcinogens; Carotid Arteries; Chloramphenicol; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Injections, Intravenous; Jugular Veins; Male; Methylcholanthrene; Phenobarbital; Proadifen; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley | 1998 |
cDNA cloning and expression of a novel CYP3A from the Syrian hamster, CYP3A31.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Northern; Blotting, Western; Cloning, Molecular; Cricetinae; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; In Situ Hybridization; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Phenobarbital; Polymerase Chain Reaction; Sequence Homology, Amino Acid | 1998 |
The enzyme inducers 3-methylcholanthrene and phenobarbital affect the activities of glucocorticoid hormone-regulated enzymes in rat liver and kidney.
Topics: Animals; Enzyme Induction; Female; Glucocorticoids; Kidney; Liver; Methylcholanthrene; Phenobarbital; Rats; Rats, Wistar | 1998 |
Modulation of snake hepatic cytochrome P450 by 3-methylcholanthrene and phenobarbital.
Topics: Animals; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Snakes | 1998 |
Effect of 3-methylcholanthrene administration on expression of cytochrome P-450 isoforms induced by phenobarbital in rat hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Cytoplasm; Immunoenzyme Techniques; In Situ Hybridization; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid Hydroxylases | 1998 |
Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.
Topics: Amides; Animals; Aryl Hydrocarbon Hydroxylases; Benzamidines; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Free Radicals; Guanidines; Hydrogen Bonding; Hydroxylamines; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Nitrogen Oxides; Oxidation-Reduction; Oximes; Oxygen Isotopes; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Xanthine; Xanthine Oxidase | 1998 |
Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice.
Topics: Aniline Hydroxylase; Animals; Blotting, Northern; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes, Liver; Oleanolic Acid; Oxidoreductases; Phenobarbital; Protein Isoforms; Pyridines; Saponins; Time Factors | 1998 |
Evidence for O-dealkylation of 7-pentoxyresorufin by cytochrome P450 2B1/2B2 isoenzymes in brain.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Brain; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dealkylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Oxazines; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases | 1998 |
[Heat shock modulates xenobiotic cytotoxicity in vivo].
Topics: Acrylamide; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Hot Temperature; Male; Methylcholanthrene; Phenobarbital; Rats; Shock; Sleep | 1998 |
Liver microsomal cytochromes P450-dependent alkoxyphenoxazone O-dealkylation in vitro by alligator and rat: activities, inhibition, substrate preference, and discrimination factors.
Topics: Alligators and Crocodiles; Animals; Chlorodiphenyl (54% Chlorine); Clofibrate; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Species Specificity; Substrate Specificity | 1999 |
Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis.
Topics: Animals; Apoptosis; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Enzyme Induction; Glucuronosyltransferase; Immunohistochemistry; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Transforming Growth Factor beta | 1998 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid | 1998 |
Induction time course of cytochromes P450 by phenobarbital and 3-methylcholanthrene pretreatment in liver microsomes of Alligator mississippiensis.
Topics: Alligators and Crocodiles; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Inactivation, Metabolic; Kinetics; Methylcholanthrene; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Time Factors | 1998 |
Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes.
Topics: Acetaminophen; Acute-Phase Proteins; Albumins; Analgesics, Non-Narcotic; Animals; Carcinogens; Cell Survival; Cells, Cultured; Coculture Techniques; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Down-Regulation; Isoenzymes; Kupffer Cells; Lipopolysaccharides; Liver; Male; Methylcholanthrene; Nitric Oxide; Phenobarbital; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xenobiotics | 1999 |
Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Topics: Acrylonitrile; Animals; Benzimidazoles; Cyanides; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Hydrogen-Ion Concentration; Kidney; Male; Methylcholanthrene; Microsomes; NADP; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfhydryl Compounds; Temperature | 1999 |
Effects of pretreatment with cytochrome P-450 inducers, especially phenobarbital on triphenyltin metabolism and toxicity in hamsters.
Topics: Animals; Aspartate Aminotransferases; beta-Naphthoflavone; Blood Glucose; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Organotin Compounds; Phenobarbital; Triglycerides | 1999 |
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Topics: Animals; Cell Count; Cell Division; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Hyperplasia; Hypertrophy; Male; Methylcholanthrene; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1999 |
Cloning and expression analysis of a new member of the cytochrome P450, CYP2A15 from the Chinese hamster, encoding testosterone 7alpha-hydroxylase.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cloning, Molecular; Cricetinae; Cytochrome P-450 Enzyme System; DNA, Complementary; Female; Gene Expression; Hydroxylation; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes; Molecular Sequence Data; Phenobarbital; Phylogeny; Recombinant Proteins; Rifampin; Steroid Hydroxylases; Testosterone; Tissue Distribution | 1999 |
Metabolism of tauromustine in liver and lung microsomes from various species.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes; Dogs; Female; Humans; Lung; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Nitrosourea Compounds; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Species Specificity; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Taurine; Testosterone | 1999 |
Cytochrome P450 (P450) isoenzyme specific dealkylation of alkoxyresorufins in rat brain microsomes.
Topics: Alkylation; Animals; Aryl Hydrocarbon Hydroxylases; Brain; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes; Oxazines; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases; Subcellular Fractions; Substrate Specificity; Xenobiotics | 1999 |
Cytochrome P450 isoforms catalyzing benzo[a]pyrene metabolism in the Chinese hamster liver.
Topics: Animals; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; In Vitro Techniques; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Phenobarbital | 1999 |
The effect of inducing agents on the metabolism of ethidium bromide by isolated rat hepatocytes.
Topics: Animals; Biotransformation; Cell Separation; Chromatography, High Pressure Liquid; Ethidium; Liver; Male; Mass Spectrometry; Methylcholanthrene; Phenobarbital; Rats; Rats, Sprague-Dawley; Time Factors; Trypanocidal Agents | 1999 |
CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Topics: Aminolevulinic Acid; Animals; Antibodies; Blotting, Western; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Imidazoles; Iron; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxazines; Oxidation-Reduction; Phenobarbital; Time Factors; Uroporphyrinogens; Uroporphyrins | 2000 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |
Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction.
Topics: Animals; Cell Adhesion; Cell Survival; Cells, Cultured; Coculture Techniques; Cryopreservation; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Induction; Glutathione Transferase; Hydroxytestosterones; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Sprague-Dawley | 2000 |
Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens.
Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Division; Chlorodiphenyl (54% Chlorine); Dextrans; Fluorescent Dyes; Gap Junctions; Image Processing, Computer-Assisted; Immunohistochemistry; Isoquinolines; Liver; Male; Methylcholanthrene; Microscopy, Fluorescence; Phenobarbital; Pregnenolone Carbonitrile; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Rhodamines; Signal Transduction; Specific Pathogen-Free Organisms | 2000 |
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Castration; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Liver; Male; Membrane Proteins; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; RNA, Messenger; Sex Characteristics; Sexual Maturation; Testosterone | 2000 |
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
Topics: Animals; Chlorodiphenyl (54% Chlorine); Detergents; Enzyme Induction; Glucuronides; Glucuronosyltransferase; In Vitro Techniques; Iodine Radioisotopes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroxine; Triiodothyronine | 2000 |
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; beta-Naphthoflavone; Blotting, Western; Cell Size; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Epidermal Growth Factor; Hepatocyte Growth Factor; Humans; Isoenzymes; Liver; Methylcholanthrene; Mixed Function Oxygenases; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenobarbital; Rifampin; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Vault Ribonucleoprotein Particles | 2000 |
Molecular cloning and characterization of three novel cytochrome P450 2D isoforms, CYP2D20, CYP2D27, and CYP2D28 in the Syrian hamster (Mesocricetus auratus).
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cloning, Molecular; COS Cells; Cricetinae; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Female; Isoenzymes; Liver; Male; Mesocricetus; Methylcholanthrene; Mixed Function Oxygenases; Molecular Sequence Data; Phenobarbital; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Effects of enzyme inducers or inhibitors on the pharmacokinetics of intravenous parathion in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Insecticides; Isoenzymes; Isoniazid; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Paraoxon; Parathion; Phenobarbital; Proadifen; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2000 |
Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Blotting, Western; Clofibrate; Cycloheximide; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dactinomycin; Deoxyadenosines; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Alignment; Transcription, Genetic | 2001 |
Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver.
Topics: Animals; Benzene Derivatives; Benzoquinones; Biotransformation; Carbon Isotopes; Chloranil; Cytosol; Environmental Pollutants; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Horseradish Peroxidase; Hydrogen Peroxide; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Quinones; Rats; Species Specificity | 2001 |
Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates.
Topics: Adenosylhomocysteinase; Aminopyrine N-Demethylase; Animals; Cytosol; Energy Metabolism; Enzyme Induction; Female; Genes, ras; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase; Glucuronosyltransferase; Glutathione Transferase; Humans; Hydrolases; L-Lactate Dehydrogenase; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Microsomes, Liver; Pharmaceutical Preparations; Phenobarbital; Polymerase Chain Reaction; Proto-Oncogene Mas; Pyruvate Kinase | 2001 |
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays.
Topics: Animals; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Drug Evaluation, Preclinical; Energy Metabolism; Gene Expression Profiling; Liver; Male; Methylcholanthrene; Oligonucleotide Array Sequence Analysis; Phenobarbital; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Stress, Physiological; Transcriptional Activation; Xenobiotics | 2001 |
Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.
Topics: Animals; Anion Transport Proteins; Carrier Proteins; Enzyme Induction; Liver; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; Organic Anion Transporters, Sodium-Independent; Phenobarbital; Pregnenolone Carbonitrile; Rats; RNA, Messenger; Time Factors | 2001 |
Induction of rat liver cytochrome P450 isoenzymes CYP 1A and CYP 2B by different fungicides, nitrofurans, and quercetin.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Ethidium; Fungicides, Industrial; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Nitrofurans; Phenobarbital; Quercetin; Rats; Rats, Wistar | 2001 |
Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.
Topics: Benzoflavones; beta-Naphthoflavone; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Inactivation, Metabolic; Keratinocytes; Methylcholanthrene; Metyrapone; Oxidoreductases; Phenobarbital; Xenobiotics | 2001 |
Long-term maintenance of cytochrome P450 activities by rat hepatocyte/3T3 cell co-cultures in heparinized human plasma.
Topics: 3T3 Cells; Animals; Coculture Techniques; Culture Media; Cytochrome P-450 Enzyme System; Fibroblasts; Heparin; Hepatocytes; Humans; Methylcholanthrene; Mice; Phenobarbital; Rats | 2001 |
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrenes; Bile; Biliary Tract; Carrier Proteins; Drug Interactions; Gene Expression Regulation; Glutathione; Hyperbilirubinemia; Immunohistochemistry; Liver; Male; Membrane Transport Proteins; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfhydryl Compounds | 2002 |
Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
Topics: Animals; Benzopyrenes; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; NADP; Phenobarbital; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 2002 |
Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cobalt; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Paraquat; Phenobarbital; Phenytoin; Proadifen; Rabbits; Rifampin; Troleandomycin; Vitamin E | 2002 |
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Animal; Drug Synergism; Glutathione; Hepatic Encephalopathy; Injections, Intravenous; Injections, Subcutaneous; Liver; Liver Failure; Male; Methylcholanthrene; Phenobarbital; Rabbits | 2002 |
Pretreatment of rats with the inducing agents phenobarbitone and 3-methylcholanthrene ameliorates the toxicity of chromium (VI) in hepatocytes.
Topics: Animals; Carcinogens, Environmental; Cell Survival; Cells, Cultured; Chromium; Dose-Response Relationship, Drug; Enzyme Induction; Glutathione; Glutathione Reductase; Hepatocytes; Male; Methylcholanthrene; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rats; Rats, Sprague-Dawley | 2002 |
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Insecticides; Male; Methylcholanthrene; Motor Activity; Nervous System Diseases; Neurotoxins; Nitriles; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Tremor | 2003 |
Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.
Topics: Animals; Antioxidants; Butylated Hydroxyanisole; Carcinogens; Catalysis; DNA-Binding Proteins; Female; Ligands; Male; Methylcholanthrene; Mice; Mice, Knockout; Mice, Transgenic; Models, Chemical; Mutation; NF-E2-Related Factor 2; Phenobarbital; Receptors, Aryl Hydrocarbon; Time Factors; Trans-Activators | 2003 |
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers.
Topics: Administration, Oral; Animals; Cell Division; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Thyroid Gland; Thyrotropin | 2003 |
Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice.
Topics: Animals; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Gene Expression; Hepatocytes; Hydroxylation; Liver; Methylcholanthrene; Mice; Mice, Transgenic; Phenobarbital; Rifampin; RNA, Messenger; Testosterone; Transcription Factors | 2003 |
Induction of P450 monooxygenases in the German cockroach, Blattella germanica L.
Topics: Acetone; Animals; Benzene Derivatives; beta-Naphthoflavone; Blattellidae; Cytochrome P-450 Enzyme System; Cytochromes b5; Enzyme Induction; Ethanol; Isoenzymes; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; RNA, Messenger | 2003 |
[Metabolism of 2,3,3',4,4'-pentachlorobiphenyl in hamsters].
Topics: Animals; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Wistar; Species Specificity; Structure-Activity Relationship | 2003 |
Effects of 3-methylcholanthrene and phenobarbital on amino acid incorporation into protein.
Topics: Amino Acids; Animals; Liver; Methylcholanthrene; Microsomes; Phenobarbital; Proteins; Rats | 1961 |
Increased activity of androgen hydroxylases in liver microsomes of rats pretreated with phenobarbital and other drugs.
Topics: Androgens; Animals; Anti-Allergic Agents; Histamine H1 Antagonists; Liver; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Rats; Testosterone | 1963 |
STUDIES ON THE METABOLIC N-DEMETHYLATION. III. ACCELERATION OF DRUG METABOLIZING ENZYME IN RAT LIVER.
Topics: Acetanilides; Barbiturates; Benzopyrenes; Liver; Metabolism; Methylcholanthrene; p-Dimethylaminoazobenzene; Pharmacology; Phenobarbital; Research | 1963 |
PUROMYCIN INHIBITION OF ENZYME INDUCTION BY 3-METHYLCHOLANTHRENE AND PHENOBARBITAL.
Topics: Anti-Bacterial Agents; Antimetabolites; Azo Compounds; Enzyme Induction; Enzyme Inhibitors; Hydrolases; Liver; Methylcholanthrene; Orphenadrine; Pharmacology; Phenobarbital; Phenylbutazone; Piperazines; Puromycin; Rats; Research | 1963 |
THE EFFECTS OF IONIZING RADIATIONS ON THE BIOCHEMISTRY OF MAMMALIAN TISSUES. I. THE INFLUENCE OF X-IRRADIATION AND CHEMICAL AGENTS ON DETOXIFICATION MECHANISMS. QUART PROGR REP 49.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Benzopyrenes; Dactinomycin; Liver; Methylcholanthrene; Nikethamide; Organophosphate Poisoning; Pharmacology; Phenobarbital; Phosphorus; Poisons; Puromycin; Radiation Injuries; Radiation Injuries, Experimental; Radiation, Ionizing; Rats; Research; Toxicology | 1963 |
THE INFLUENCE OF PHENOBARBITAL ADMINISTRATION UPON THE "SOLUBLE" NADP-REQUIRING ENZYMES IN LIVER.
Topics: Aminopyrine; Benzopyrenes; Citrates; Diphenhydramine; Ethionine; Fluorouracil; Gluconates; Hexosephosphates; Isocitrate Dehydrogenase; Liver; Mercaptopurine; Methylcholanthrene; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylalanine; Rats; Research; Uracil | 1964 |
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS.
Topics: Aminopyrine; Androgens; Benzopyrenes; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Ethionine; Liver; Liver Neoplasms; Methionine; Methylcholanthrene; Microsomes; Microsomes, Liver; Orphenadrine; Pharmacology; Phenobarbital; Phenylbutazone; Polycyclic Compounds; Rats; Research; Zoxazolamine | 1963 |
FACTORS THAT AFFECT THE STIMULATION OF THE MICROSOMAL DRUG ENZYMES INDUCED BY FOREIGN COMPOUNDS.
Topics: Acetanilides; Adrenocorticotropic Hormone; Benzopyrenes; Hexobarbital; Liver; Methylcholanthrene; Methyltestosterone; Microsomes; Nandrolone; Pharmacology; Phenobarbital; Pyrazoles; Rats; Research; Testosterone; Zoxazolamine | 1963 |
BIOCHEMISTRY OF REGULATION OF ENZYME ACTIVITY AND SYNTHESIS. SESSION CHAIRMAN'S COMMENTS.
Topics: Adenosine Triphosphate; Biochemistry; Carcinoma, Hepatocellular; Feedback; Liver; Liver Neoplasms; Methylcholanthrene; Phenobarbital | 1963 |
ENHANCED ANDROGEN HYDROXYLASE ACTIVITY IN LIVER MICROSOMES OF RATS AND DOGS TREATED WITH PHENYLBUTAZONE.
Topics: Androgens; Animals; Chromatography; Cortisone; Dogs; Hydrocortisone; Liver; Metabolism; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Pharmacology; Phenobarbital; Phenylbutazone; Rats; Research; Testosterone | 1964 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmacology; Phenobarbital; Proadifen; Rats; Research; Sex; Steroid Hydroxylases; Testosterone | 1964 |
MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.
Topics: Benz(a)Anthracenes; Benzopyrenes; Chlordan; Electrons; Histocytochemistry; Liver; Liver Glycogen; Methylcholanthrene; Microscopy; Microscopy, Electron; Microsomes; Pharmacology; Phenobarbital; Rats; Research; Toxicology | 1965 |
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES.
Topics: Aspirin; Blood; Chromatography; Dicumarol; Diphenhydramine; Dogs; Drug-Related Side Effects and Adverse Reactions; Glutethimide; Griseofulvin; Histamine H1 Antagonists; Liver; Meprobamate; Metabolism; Methylcholanthrene; Pentobarbital; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Piperazines; Probenecid; Rats; Research; Strychnine; Thiopental; Toxicology; Zoxazolamine | 1965 |
DRUG-INDUCED CHANGES IN STEROID METABOLISM.
Topics: Androsterone; Chromatography; Corticosterone; Cortisone; Dogs; Estradiol; Hexobarbital; Histamine H1 Antagonists; Hydrocortisone; Liver; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Phenylbutazone; Piperazines; Rats; Research; Steroids; Testosterone; Toxicology | 1965 |
Phylogenetic tree facilitates the understanding of gene expression data on drug metabolizing enzymes obtained by microarray analysis.
Topics: Administration, Oral; Animals; Base Sequence; Butylated Hydroxyanisole; Clofibrate; Cytochrome P-450 Enzyme System; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Phenobarbital; Phylogeny; Rats; Rats, Inbred F344; Xenobiotics | 2003 |
The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes.
Topics: Animals; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Diminazene; Enzyme Induction; Hepatocytes; Humans; In Vitro Techniques; Male; Methylcholanthrene; Nitriles; Pentamidine; Phenobarbital; Pyrethrins; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Trypanocidal Agents | 2003 |
A comparative study on the effect of phenobarbitol and beta-methylcholanthrene on glutathione S-transferases of rat testis.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase; Isoenzymes; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Wistar; Substrate Specificity; Testis | 2002 |
Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens.
Topics: 2-Acetylaminofluorene; Animal Testing Alternatives; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Enzymes; Female; Liver; Methylcholanthrene; Methylenebis(chloroaniline); Phenobarbital; Phosphorus Radioisotopes; Quinoxalines; Rats; Rats, Inbred F344; Rats, Wistar; Turkey | 2004 |
Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction.
Topics: Alginates; Animals; Cell Culture Techniques; Cells, Cultured; Coculture Techniques; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Enzyme Induction; Glucuronic Acid; Glutathione Transferase; Hepatocytes; Hexuronic Acids; Liver; Male; Methylcholanthrene; Microspheres; Phenobarbital; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Technology, Pharmaceutical | 2005 |
Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Isoniazid; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; Models, Animal; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2005 |
[Metabolism of 2, 3', 4, 4', 5-pentachlorobiphenyl in guinea pig microsomes].
Topics: Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls | 2005 |
Comparative study on glutathione transferases of rat brain and testis under the stress of phenobarbitol and beta-methylcholanthrene.
Topics: Animals; Brain; Exercise Test; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Wistar; Testis | 2005 |
Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Benzopyrene Hydroxylase; Carbon Monoxide; Carcinogens; Carrier Proteins; Ethionine; Hemeproteins; Hypnotics and Sedatives; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Nitriles; Phenobarbital; Pigments, Biological; Rats; Rats, Sprague-Dawley; Spectrophotometry | 1967 |
Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C.
Topics: Animals; Blotting, Western; Butylated Hydroxyanisole; Caco-2 Cells; Down-Regulation; Electrophoretic Mobility Shift Assay; Glutathione Transferase; Hepatocyte Nuclear Factor 1-alpha; Humans; Methylcholanthrene; Mice; Phenobarbital; Protein Binding; Protein Isoforms; Rats; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic; Xenobiotics | 2006 |
Influences of 3-methylcholanthrene, phenobarbital and dexamethasone on xenobiotic metabolizing-related cytochrome P450 enzymes and steroidogenesis in human fetal adrenal cortical cells.
Topics: Adrenal Cortex; Aminopyrine N-Demethylase; Benzphetamine; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethasone; Fetus; Humans; Methylcholanthrene; Phenobarbital; Pregnenediones; Xenobiotics | 2006 |
Cytochrome p450 expression of cultured rat small hepatocytes after long-term cryopreservation.
Topics: Animals; Carbon Radioisotopes; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Chromatography, High Pressure Liquid; Collagen; Cryopreservation; Cytochrome P-450 Enzyme System; Drug Combinations; Ethanol; Hepatocytes; Immunoblotting; Isoenzymes; L-Serine Dehydratase; Laminin; Liver; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Proteoglycans; Rats; Rats, Inbred F344; Testosterone; Time Factors | 2006 |
Proteomic profiles of induced hepatotoxicity at the subcellular level.
Topics: Animals; Cytosol; Electrophoresis, Gel, Two-Dimensional; Liver Extracts; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Proteome; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Metabolism of isometamidium in hepatocytes isolated from control and inducer-treated rats.
Topics: Animals; Hepatocytes; Male; Mass Spectrometry; Methylcholanthrene; Microscopy, Confocal; Nitriles; Phenanthridines; Phenobarbital; Pyrethrins; Rats; Rats, Sprague-Dawley; Trypanocidal Agents | 2006 |
[Metabolism of 2,2',4,5,5'-pentachlorobiphenyl (CB101) by liver microsomes of rats, hamsters and guinea pigs].
Topics: Animals; Cricetinae; Cytochrome P-450 Enzyme System; Guinea Pigs; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rats | 2007 |
Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450.
Topics: Animals; Antibodies, Blocking; Biotransformation; Cricetinae; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Flavones; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Wistar; Recombinant Proteins | 2007 |
Responsiveness of cerebral and hepatic cytochrome P450s in rat offspring prenatally exposed to lindane.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hexachlorocyclohexane; Insecticides; Liver; Male; Methylcholanthrene; Neurotoxicity Syndromes; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2008 |
Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Methylcholanthrene; Pharmaceutical Preparations; Phenobarbital; Reproducibility of Results; Rifampin; Tandem Mass Spectrometry | 2008 |
Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver.
Topics: Animals; Base Sequence; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Diterpenes; DNA Primers; Female; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Orchiectomy; Ovariectomy; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Testosterone | 2010 |
Differential effects of ethanol and other inducers of drug metabolism on the two forms of hamster liver microsomal aniline hydroxylase.
Topics: Aniline Hydroxylase; Animals; Chlorodiphenyl (54% Chlorine); Cricetinae; Enzyme Induction; Ethanol; Isoenzymes; Kinetics; Liver; Male; Mesocricetus; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Random Allocation | 1980 |
Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals.
Topics: Animals; Apoptosis; Biomarkers; Cytochrome P-450 Enzyme System; Environmental Exposure; Environmental Pollutants; Ethanol; Inflammation; Liver; Lymphocytes; Male; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Methylcholanthrene; Phenobarbital; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA; Transcription Factors; Transcriptome | 2013 |
Maintenance of in vivo induced cytochrome P-450s in hepatocyte monolayers at non freezing temperatures.
Topics: Animals; Cell Adhesion; Cell Survival; Cells, Cultured; Collagen; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inducers; Dexamethasone; Enzyme Induction; Freezing; Hepatocytes; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Sprague-Dawley; Temperature; Testosterone | 2015 |
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Topics: Animals; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Fatty Acids; Fatty Liver; Liver; Male; Methylcholanthrene; Orotic Acid; Oxidation-Reduction; Peroxisomes; Phenobarbital; Rats, Sprague-Dawley; Sirtuin 1 | 2015 |