3-methylcholanthrene has been researched along with nadp in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 137 (91.33) | 18.7374 |
| 1990's | 11 (7.33) | 18.2507 |
| 2000's | 2 (1.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hildebraunt, AG; Roots, I | 1 |
| Slaga, TJ; Thompson, S | 1 |
| Hunter, AL; Neal, RA | 1 |
| Uehleke, H; Werner, T | 1 |
| Alexandrov, K; Brookes, P; King, HW; Osborne, MR; Thompson, MH | 1 |
| Konno, K; Sato, H; Watanabe, M | 1 |
| Jernström, B; Orrenius, S; Vadi, H | 1 |
| Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M | 1 |
| Aronson, I; Ivanetich, KM; Katz, ID | 1 |
| Jacquignon, P; Latarjet, R; Perin, F; Perin-Roussel, O; Yoshikura, H; Zajdela, F | 1 |
| Bracken, WM; Buty, SG; Slaga, TJ; Thompson, S; Viaje, A | 1 |
| Hinson, JA; Mitchell, JR; Nelson, SD | 1 |
| De Raat, WK | 1 |
| Kumaki, K; Nebert, DW; Shichi, H | 1 |
| Kicha, LP; Strickhart, FS; Yang, CS | 1 |
| Capdevila, J; Estabrook, RW; Prough, RA | 1 |
| Kennan, KA; Lin, JK; Miller, EC; Miller, JA | 1 |
| Aust, SD; Dannan, GA; Moore, RW | 1 |
| Hara, E; Kawajiri, K; Masuda, A; Tagashira, Y; Yonekawa, H | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 1 |
| Buhler, DR; Henderson, MC; Miller, A | 1 |
| Iamkovoĭ, VI; Liakhovich, VV; Pospelova, LN; Tsyrlov, IB; Vaĭner, LM | 1 |
| Jergil, B; Schelin, C; Tunek, A | 1 |
| Arcos, JC; Argus, MF; Lai, DY | 1 |
| Kamataki, T; Kitada, M; Kitagawa, H; Shigematsu, H | 1 |
| Dave, CV; Gurtoo, HL | 1 |
| Gelboin, HV; Leutz, JC; Wiebel, FJ | 1 |
| Bejba, N; Gurtoo, HL; Minowada, J | 1 |
| Kawalek, JC; Lu, AY | 1 |
| Wiebel, FJ | 1 |
| Bridges, JW; Burke, MD | 1 |
| Pietropaolo, C; Weinstein, IB | 1 |
| Booth, J; Hewer, A; Keysell, GR; Sims, P | 1 |
| Conney, AH; Kuntzman, R; Levin, W; Lu, AY; Ryan, D; Vore, M; West, SB | 1 |
| Caygill, CP; Diplock, AT; Giasuddin, AS; Jeffery, EH | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Ariji, F; Konno, K; Takusagawa, K; Watanabe, M | 1 |
| Cho, AK; Hodshon, BJ; Jonsson, J; Lindeke, B | 1 |
| Bradlow, HL; Jellinck, PH; Michnovicz, JJ | 1 |
| Bray, TM; Chen, GM; Janzen, EG; McCay, PB | 1 |
| Brauze, D; Mikstacka, R; Pelkonen, O | 1 |
| Jacobs, JM; Lambrecht, RW; Sinclair, JF; Sinclair, PR | 1 |
| Majeska, JB; Matheson, DW | 1 |
| Fu, PP; Jacobs, MM; Prasanna, P; Weems, HB; Yang, SK | 1 |
| Benes, L; Stefek, M; Zelník, V | 1 |
| Isobe, M; Ozawa, N; Sone, T; Takabatake, E; Watabe, T | 1 |
| Leach, MF; Lin, KH; Lindahl, R; Winters, AL | 1 |
| Colby, HD; Dalal, NS; LaCagnin, LB; O'Donnell, JP | 1 |
| Gräslund, A; Jernström, B; Waern, F | 1 |
| Button, J; Clawson, GA; Geller, DA; Hammock, BD; Loury, DN; Moody, DE; Smuckler, EA; Taylor, LA | 1 |
| Artemova, LG; Pakhomov, VIu; Shuliakovskaia, TS | 1 |
| Bosman, P; de Vries, J; van de Straat, R; Vermeulen, NP; Vromans, RM | 1 |
| Iba, MM; Lang, B | 1 |
| Lindahl, R; Marselos, M | 1 |
| Conway, JG; Evans, RK; Jerkins, AA; Kauffman, FC; Reinke, LA; Thurman, RG | 1 |
| Ghersi-Egea, JF; Jayyosi, Z; Minn, A; Siest, G; Walther, B | 1 |
| Benediktova, SA; Devichenskiĭ, VM; Izotov, MV; Lugovaia, LV; Shcherbakov, VM | 1 |
| Elder, GH; Urquhart, AJ | 1 |
| Smith, AG; Stewart, FP | 1 |
| Gram, TE; Okine, LK | 1 |
| Chiu, PL; Yang, SK | 1 |
| Engell, RJ; Holm, KA; Kupfer, D | 1 |
| Kuwahara, S; Mannering, GJ | 1 |
| Müller, F; Temmink, JH; van Bladeren, PJ; van Ommen, B | 1 |
| Madyastha, KM; Madyastha, P; Moorthy, B; Vaidyanathan, CS | 1 |
| Kato, R; Oshima, T; Takahashi, A | 1 |
| Van Dyke, RA; Wood, CL | 1 |
| Flynn, EJ; Lynch, M; Zannoni, VG | 1 |
| Ito, A; Minakami, S; Takeshige, K | 1 |
| Correia, MA; Mannering, GJ | 1 |
| Jondorf, WR; MacIntyre, DE; Powis, G | 1 |
| Mazel, P; Shargel, L | 2 |
| Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ | 1 |
| Fujita, T; Mannering, GJ | 1 |
| Hildebrandt, AG; Roots, I; Speck, M | 1 |
| Jacobson, M; Kuntzman, R; Levin, W; Lu, AY; McCay, PB; Poyer, JL | 1 |
| Levin, W; Lu, AY; Ryan, D; West, S | 1 |
| Bellward, GD; Morgan, RG; Szombathy, VH | 1 |
| Bresnick, E; Bürki, K; Stoming, TA | 1 |
| Stawarz, RJ; Stitzel, RE | 1 |
| Ames, BN; Durston, WE; Lee, FD; Yamasaki, E | 1 |
| Cavalieri, E; Rogan, EG | 1 |
| Neal, RA; Norman, BJ; Poore, RE | 1 |
| Kagan, VE; Kotelevtsev, SV; Kozlov, IuP | 1 |
| Allen, LM; Creaven, PJ; Williams, CP | 1 |
| O'Brien, PJ; Rahimtula, AD | 1 |
| Alexandrov, K; Frayssinet, C | 1 |
| Booth, J; Sims, P | 1 |
| Hershberger, WK; Juchau, MR; Pedersen, MG | 1 |
| Strickhart, FS; Yang, CS | 1 |
| Behrens, BC; Bryan, GT; Ichikawa, M; Wang, CY | 1 |
| Jerina, DM; Levin, W; Lu, AY; Selander, H | 1 |
| Fouts, JR; Juchau, MR; Mullen, JO | 1 |
| Gillette, JR; Hernandez, PH; Mazel, P | 1 |
| Estabrook, RW | 1 |
| Gelboin, HV; Nebert, DW | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 1 |
| Kato, R; Oshima, T; Takanaka, A | 1 |
| Prough, RA; Reed, DJ; Wittkop, JA | 1 |
| Dallner, G; Glaumann, H; Kuylenstierna, B | 1 |
| Bogdan, D; Juchau, MR | 1 |
| Fletcher, R; Jellinck, PH; Smith, G | 1 |
| Gillette, JR | 1 |
| Chauveau, J; Meunier, M | 1 |
| Rabin, BR; Williams, DJ | 1 |
| Alvares, AP; Kuntzman, R; Levin, W; Schilling, G | 1 |
| Juchau, MR | 1 |
| Feller, DR; Gillette, JR; Morita, M | 1 |
| Alvares, AP; Kappas, A; Mitani, F; Sassa, S | 1 |
| Lombrozo, L; Mitoma, C | 1 |
| Fouts, JR; Hansen, AR | 1 |
| Diaugustine, RP; Eling, TE; Fouts, JR | 1 |
| Glaumann, H | 1 |
| Conney, AH; Jacobson, M; Kuntzman, R; Lu, AY; West, S | 1 |
| Glazer, RI; Sartorelli, AC; Schenkman, JB | 1 |
| Van Dyke, RA; Wineman, CG | 1 |
| Jacobson, MM; Kuntzman, R; Poland, A; Tsai, I | 1 |
| Carlson, GP; Fausto, N; Fuller, GC; Suarez, KA | 1 |
| Lu, AY; West, SB | 1 |
| Nebert, DW; Poland, AP | 1 |
| James, MO; Little, PJ | 1 |
| Narimatsu, S; Watanabe, K; Yamamoto, I; Yoshimura, H | 1 |
| Fujimori, K; Inoue, K; Mizokami, K; Omori, Y; Sunouchi, M; Takanaka, A; Yubisui, T | 1 |
| Nemoto, N; Takayama, S | 1 |
| Crowley, P; Fuhrman-Lane, C; Ortiz, E; Shiverick, KT | 1 |
| Kagan, VE; Savov, VM; Serbinova, EA | 1 |
| Mukhtar, H; Seth, PK; Srivastava, SP | 1 |
| Conway, JG; Kauffman, FC; Thurman, RG | 1 |
| Hashimoto, K; Kinoshita, K; Suzuki, Y; Takahashi, G; Yasuhira, K | 1 |
| Erjomin, AN; Metelitza, DI; Tishchenko, IV; Usanov, SA | 1 |
| Bradshaw, TK; Freedman, RB; Kaderbhai, MA | 1 |
| Ahr, H; Nastainczyk, W; Ulrich, V | 1 |
| Hollenberg, PF; Koop, DR | 1 |
| Chiba, K; Imai, Y; Kamataki, T; Kitada, M; Kitagawa, H; Sato, R | 1 |
| Boyd, MR; Franklin, RB; Sasame, HA | 1 |
| Kunze, KL; Ortiz de Montellano, PR | 1 |
| Inoue, T; Murata, T; Niwaguchi, T | 1 |
| Baird, MB | 1 |
| Kuwahara, S; Omura, T | 1 |
| Harada, N; Noshiro, M; Omura, T | 1 |
| Kitada, M; Kitagawa, H; Misaizu, T; Nakamura, T; Ohmori, S; Takano, N | 1 |
| Lenk, W; Rosenbauer-Thilmann, R | 1 |
| Ariyoshi, N; Koga, N; Matsusue, K; Oguri, K; Yoshimura, H | 1 |
| Cueto, R; Pryor, WA; Salgo, MG; Winston, GW | 1 |
| Abdel-Aziz, AH; Abdel-Naim, AB; Abo-Salem, O; Hamada, FM; Mostafa, AM | 1 |
| Lin, PH; Rappaport, SM; Tsai, CH; Waidyanatha, S | 1 |
| Degenhardt, C; Frank, H; Grupe, S; Platt, KL; Seidel, A | 1 |
| BRESNICK, E; YANG, HY | 1 |
| Ballow, C; Belinsky, SA; Evans, RK; Kauffman, FC; Reinke, LA; Thurman, RG | 1 |
150 other study(ies) available for 3-methylcholanthrene and nadp
| Article | Year |
|---|---|
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes.
Topics: Animals; Azides; Ethanol; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone; Rats; Scopoletin | 1975 |
Mouse epidermal aryl hydrocarbon hydroxylase.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Enzyme Induction; Histological Techniques; In Vitro Techniques; Methylcholanthrene; Mice; NADP; Skin; Temperature | 1976 |
Inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds.
Topics: Animals; Benzphetamine; Cytochrome P-450 Enzyme Inhibitors; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Thiones; Time Factors | 1975 |
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo.
Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity | 1975 |
Comparison of the metabolism of benzo[alpha]pyrene and binding to DNA caused by rat liver nuclei and microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; DNA; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; NADP; Rats | 1976 |
Properties of aryl hydrocarbon hydroxylase in microsomes of Morris hepatoma 5123D and the host liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocellular; Epoxide Hydrolases; Flavonoids; Hydrogen-Ion Concentration; Kinetics; Liver Neoplasms; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Rats; Sarcoma 180 | 1975 |
Formation in isolated rat liver microsomes and nuclei of benzo(a)pyrene metabolites that bind to DNA.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochromes; DNA; Epoxide Hydrolases; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Rats; Time Factors | 1976 |
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats.
Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes | 1976 |
The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro.
Topics: Animals; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Spectrophotometry; Vinyl Chloride; Vinyl Compounds | 1977 |
Enhancement of 5-iododeoxyuridine-induced endogenous C-type virus activation by polycyclic hydrocarbons: apparent lack of parallelism between enhancement and carcinogenicity.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benzopyrenes; Carcinogens; Cells, Cultured; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Flavonoids; Idoxuridine; In Vitro Techniques; Kinetics; Methylcholanthrene; Mixed Function Oxygenases; NADP; Polycyclic Compounds; Retroviridae; Virus Replication | 1977 |
A kinetic study on the in vitro covalent binding of polycyclic hydrocarbons to nucleic acids using epidermal homogenates as the activating system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzopyrenes; DNA; Female; In Vitro Techniques; Kinetics; Methylcholanthrene; Mice; NADP; Poly A; Poly G; Polycyclic Compounds; RNA; Skin | 1977 |
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin.
Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital | 1977 |
The induction of sister chromatid exchanges by cyclophosphamide in the presence of differently induced microsomal fractions of rat liver.
Topics: Animals; Aroclors; Benzopyrene Hydroxylase; Cells, Cultured; Chromatids; Cyclophosphamide; Enzyme Induction; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats | 1977 |
Circular dichroism studies on the binding of type I substrates and reverse type I compounds to rabbit liver microsomal cytochrome P-450.
Topics: Alcohols; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Circular Dichroism; Cyclohexanes; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rabbits | 1978 |
Interaction between NADPH-cytochrome P-450 reductase and hepatic microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzphetamine; Catalysis; Coumarins; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethyl Ethers; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases, N-Demethylating; Oxygenases; Phenobarbital; Rats | 1978 |
The microsomal metabolism of benzo(a) pyrene phenols.
Topics: Animals; Benzopyrenes; Cell-Free System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Spectrum Analysis | 1978 |
Reduced nicotinamide adenine dinucleotide phosphate-dependent formation of 2,3-dihydro-2,3-dihydroxyaflatoxin B1 from aflatoxin B1 by hepatic microsomes.
Topics: Aflatoxins; Animals; Chemical Phenomena; Chemistry; Cricetinae; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats | 1978 |
Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs).
Topics: Animals; Biotransformation; Biphenyl Compounds; DNA; Female; Lactation; Male; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Phenobarbital; Polybrominated Biphenyls; Pregnancy; Protein Binding; Rats | 1978 |
In vitro binding of 2-acetaminofluorene to RNA and protein with rat liver microsomes.
Topics: 2-Acetylaminofluorene; Animals; Cytosol; Fluorenes; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Protein Binding; Proteins; Rats; RNA | 1978 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
Covalent binding of carbaryl (1-naphthyl-N-methyl-carbamate) to rat liver microsomes in vitro.
Topics: Animals; Carbaryl; Electrophoresis, Disc; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pronase; Protein Binding; Rats | 1979 |
[Cytochrome P-450 catalyzed oxidation of 1-piperidinoanthraquinone].
Topics: Animals; Anthraquinones; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme System; Deoxycholic Acid; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Piperidines; Rats; Spectrum Analysis | 1979 |
Microsomal target proteins of metabolically activated aromatic hydrocarbons.
Topics: Animals; Benzene; Benzopyrenes; Hydrocarbons; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenols; Protein Binding; Proteins; Rats; Time Factors; Uridine Diphosphate Glucuronic Acid | 1979 |
Factors influencing the microsome- and mitochondria-catalyzed in vitro binding of diethylnitrosamine and N-nitrosopiperidine to deoxyribonucleic acid.
Topics: Animals; Cytosol; Diethylnitrosamine; DNA; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Nitrosamines; Phenobarbital; Piperidines; Rats | 1979 |
The involvement of cytochrome P-488 and P-450 in NADH-dependent O-demethylation of p-nitroanisole in rat liver microsomes.
Topics: Animals; Antibodies; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport; Female; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Nitroanisole O-Demethylase; Oxidation-Reduction; Oxidoreductases; Rabbits; Rats | 1979 |
In vitro metabolic conversion of aflatoxins and benzo(alpha)pyrene to nucleic acid-binding metabolites.
Topics: Aflatoxins; Animals; Benzopyrenes; Carbon Monoxide; Cell Fractionation; DNA; Liver; Methylcholanthrene; Micrococcus; Microsomes, Liver; NADP; Nitrogen; Nucleic Acid Denaturation; Phenobarbital; Proadifen; Rats; RNA; RNA, Transfer; Spectrum Analysis; Thymus Gland; Tritium | 1975 |
Aryl hydrocarbon (benzo[a]pyrene) hydroxylase: a mixed-function oxygenase in mouse skin.
Topics: Animals; Anthracenes; Benzopyrenes; Carbon Monoxide; Enzyme Induction; Flavonoids; Injections, Intraperitoneal; Kinetics; Liver; Lung; Methylcholanthrene; Mice; Mixed Function Oxygenases; NADP; Naphthacenes; Phenanthrenes; Skin | 1975 |
Properties, inducibility, and an improved method of analysis of aryl hydrocarbon hydroxylase in cultured human lymphocytes.
Topics: Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cell Survival; Cells, Cultured; Edetic Acid; Enzyme Induction; Humans; Hydrogen-Ion Concentration; Lymphocytes; Manganese; Methylcholanthrene; Mitogens; NADP; Time Factors | 1975 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. VIII. Different catalytic activities of rabbit and rat cytochromes P-448.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cytochrome Reductases; Cytochromes; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Pharmaceutical Preparations; Proadifen; Rabbits; Rats | 1975 |
Metabolism of monohydroxybenzo(a)pyrenes by rat liver microsomes and mammalian cells in culture.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Cells, Cultured; Chromatography; Cricetinae; Embryo, Mammalian; Flavonoids; Hydroxylation; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Rats; Spectrometry, Fluorescence; Tritium | 1975 |
Biphenyl hydroxylations and spectrally apparent interactions with liver microsomes from hamsters pre-treated with phenobarbitone and 3-methylcholanthrene.
Topics: Alcohols; Animals; Biphenyl Compounds; Carbon Radioisotopes; Cricetinae; Cytochrome P-450 Enzyme System; Cytochromes; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Phenobarbital | 1975 |
Binding of [3H]benzo(a)pyrene to natural and synthetic nucleic acids in a subcellular microsomal system.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Binding Sites; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Depression, Chemical; DNA; Dose-Response Relationship, Drug; Flavonoids; Glutathione; Guanine Nucleotides; Kinetics; Magnesium; Male; Methylcholanthrene; Microsomes, Liver; Models, Biological; NADP; Nucleic Acids; Rats; RNA, Transfer; Saccharomyces cerevisiae; Stimulation, Chemical | 1975 |
Enzymic reduction of aromatic hydrocarbon epoxides by the microsomal fraction of rat liver.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Ethers, Cyclic; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxides; Oxidoreductases; Oxygen; Rats; Spectrophotometry, Ultraviolet; Subcellular Fractions | 1975 |
Role of cytochrome b5 in NADPH-and NADH-dependent hydroxylation by the reconstituted cytochrome P-450- or P-448-containing system.
Topics: Animals; Benzopyrene Hydroxylase; Benzphetamine; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Hydroxylation; Lipid Metabolism; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Rats; Spectrum Analysis; Testosterone | 1975 |
The dependence on vitamin E and selenium of drug demethylation in rat liver microsomal fractions.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Antioxidants; Castration; Dietary Proteins; Electron Transport; Haplorhini; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Selenium; Time Factors; Vitamin E; Vitamin E Deficiency | 1975 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Aryl hydrocarbon hydroxylase in liver nuclei of C3H/He and DBA/2 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Cell Nucleus; Cyclohexanes; Endoplasmic Reticulum; Epoxide Hydrolases; Female; Flavonoids; Glucose-6-Phosphatase; Liver; Methylcholanthrene; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Microsomes, Liver; NAD; NADP; Niacinamide; Nucleotidases; Phenobarbital; Propane | 1975 |
The p-hydroxylation of amphetamine and phentermine by rat liver microsomes.
Topics: Amphetamine; Aniline Hydroxylase; Animals; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Phentermine; Rats | 1975 |
Influence of indole-3-carbinol on the hepatic microsomal formation of catechol estrogens.
Topics: Animals; Cytochrome P-450 Enzyme System; Estradiol; Estrogens, Catechol; Female; Hydroxylation; Indoles; Methylcholanthrene; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains | 1991 |
The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats.
Topics: Animals; Cyclic N-Oxides; Enzyme Induction; Kidney; Liver; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen Oxides; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Spin Labels | 1991 |
Monoclonal antibody characterization of NADH- and NADPH-dependent hydroxylation of benzo(a)pyrene in liver microsomes from 5,6-benzoflavone-induced C57Bl/6 mice.
Topics: Animals; Antibodies, Monoclonal; Benzopyrene Hydroxylase; Benzopyrenes; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Hydroxylation; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NAD; NADP | 1990 |
Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation.
Topics: Animals; Carboxy-Lyases; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ketoconazole; Kinetics; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxidation-Reduction; Polychlorinated Biphenyls; Porphyrinogens; Uroporphyrinogen Decarboxylase; Uroporphyrinogens | 1990 |
Development of an optimal S9 activation mixture for the L5178Y TK+/- mouse lymphoma mutation assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cyclophosphamide; Dimethylnitrosamine; Lymphoma; Methylcholanthrene; Mice; Microsomes, Liver; Mutagenicity Tests; NADP; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 1990 |
Metabolism of the potent carcinogen 3-methylcholanthrylene by rat liver microsomes.
Topics: Animals; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Methylcholanthrene; Microsomes, Liver; NADP; Rats; Spectrum Analysis | 1990 |
N-oxygenation of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent: the role of flavin-containing monooxygenase.
Topics: Animals; Anti-Arrhythmia Agents; Flavins; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Male; Methimazole; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Oxygen; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains | 1989 |
7-ethenyloxycoumarin as a new substrate for fluorophotometric assay of hepatic microsomal epoxidizing activities.
Topics: Animals; Antibodies; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Spectrophotometry; Umbelliferones | 1989 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Karyotyping; Liver Neoplasms, Experimental; Methylcholanthrene; NADP; Neoplasm Transplantation; Organoids; Phenobarbital; Phenotype; Rats; Tyrosine Transaminase | 1986 |
Metabolic activation of hydralazine by rat liver microsomes.
Topics: Animals; Biotransformation; Electron Spin Resonance Spectroscopy; Hydralazine; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains | 1987 |
Studies by fluorescence and n.m.r. spectroscopy of the major product formed after further metabolism of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Methylcholanthrene; Microsomes, Liver; NADP; Rats; Spectrometry, Fluorescence | 1986 |
Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes.
Topics: Animals; Carbon Tetrachloride; Cell Nucleus; Cholic Acid; Cholic Acids; Cytochrome P-450 Enzyme System; Cytosol; Liver; Male; Methylcholanthrene; NAD(P)H Dehydrogenase (Quinone); NADP; NADPH-Ferrihemoprotein Reductase; Pharmaceutical Preparations; Phenobarbital; Propane; Quinone Reductases; Rats; Rats, Inbred Strains | 1988 |
[Modifying effect of antioxidants on the rate of lipid peroxidation in liver microsomes at early stages of diethylnitrosamine biotransformation].
Topics: Animals; Antioxidants; Biotransformation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Interactions; Free Radicals; Lethal Dose 50; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Electron Transport; Free Radicals; Glutathione; Glutathione Disulfide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Pyridines; Rats; Rats, Inbred Strains | 1988 |
Stimulation of the conjugation of lipid dienes in hepatic microsomes by 3,3'-dichlorobenzidine.
Topics: 3,3'-Dichlorobenzidine; Animals; Benzidines; Carbon Monoxide; Cytochrome P-450 Enzyme System; Lipid Metabolism; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Nitrogen; Rats; Rats, Inbred Strains | 1988 |
Substrate preference of a cytosolic aldehyde dehydrogenase inducible in rat liver by treatment with 3-methylcholanthrene.
Topics: Aldehyde Dehydrogenase; Animals; Enzyme Induction; Kinetics; Liver; Methylcholanthrene; NAD; NADP; Polychlorinated Dibenzodioxins; Rats | 1988 |
Maintenance of nicotinamide dinucleotide phosphate content and oxidation-reduction state during mixed-function oxidation of p-nitroanisole in isolated perfused livers of various species.
Topics: Animals; Anisoles; Cricetinae; Female; Kinetics; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Perfusion; Phenobarbital; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Ethoxyresorufin O-deethylase activity in rat brain subcellular fractions.
Topics: Animals; Brain; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Microsomes; Mitochondria; NAD; NADP; Oxidoreductases; Rats; Rats, Inbred Strains | 1987 |
[The role of vitamin K3 in the hydroxylation of benz(a)pyrene in rat liver mitochondria after induction with 3-methylcholanthrene and phenobarbital].
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Vitamin K | 1987 |
Hexachlorobenzene-induced oxygen activation by mouse liver microsomes: comparison with phenobarbitone and 20-methylcholanthrene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexachlorobenzene; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxygen; Phenobarbital | 1987 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethers, Cyclic; Isoenzymes; Male; Mathematics; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
Regioselectivity of hydroxylation of prostaglandins by liver microsomes supported by NADPH versus H2O2 in methylcholanthrene-treated and control rats: formation of novel prostaglandin metabolites.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Dinoprostone; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Prostaglandins E; Rats; Rats, Inbred Strains | 1985 |
Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes.
Topics: Animals; Antibodies; Benzoflavones; Carbon Monoxide; Cobalt; Cyanides; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochrome-B(5) Reductase; Cytochromes b5; Dealkylation; Electron Transport; Ethylmorphine; In Vitro Techniques; Linoleic Acids; Lipid Peroxides; Male; Manganese; Methylcholanthrene; Microsomes, Liver; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Nitrobenzenes; Oxygen; Partial Pressure; Phenobarbital; Proadifen; Rats | 1985 |
Formation of pentachlorophenol as the major product of microsomal oxidation of hexachlorobenzene.
Topics: Animals; Aroclors; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Chlorophenols; Chromatography, High Pressure Liquid; Female; Hexachlorobenzene; Male; Methylcholanthrene; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Proteins; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
In vivo and in vitro destruction of rat liver cytochrome P-450 by a monoterpene ketone, pulegone.
Topics: Administration, Oral; Animals; Cyclohexane Monoterpenes; Cytochrome P-450 Enzyme System; Kinetics; Male; Menthol; Methylcholanthrene; Microsomes, Liver; Monoterpenes; NADP; Phenobarbital; Rats; Time Factors | 1985 |
Characteristics of nitro reduction of the carcinogenic agent, 4-nitroINOLONE N-oxide.
Topics: Alcohol Oxidoreductases; Animals; Benzoates; Carcinogens; Dicumarol; Flavin Mononucleotide; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Oxides; Oxidoreductases; Oxygen; Phenobarbital; Quinolines; Rats; Time Factors | 1970 |
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers.
Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats | 1973 |
Species differences and drug metabolism.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitro Compounds; Oxidation-Reduction; Rats; Species Specificity; Spectrophotometry | 1972 |
Effects of Triton X-100 on drug hydroxylation system of rat liver microsomes induced by phenobarbital or 3-methylcholanthrene.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Enzyme Activation; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Rats; Surface-Active Agents | 1972 |
Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzphetamine; Codeine; Cyanides; Cytochrome P-450 Enzyme System; Drug Synergism; Female; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Morphinans; NAD; NADH, NADPH Oxidoreductases; NADP; Oxidation-Reduction; Oxidoreductases; Oxidoreductases, N-Demethylating; Phospholipases; Proadifen; Protein Binding; Rats | 1973 |
Induction of liver microsomal drug metabolism in newly-hatched chicks.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Animals, Newborn; Chick Embryo; Chickens; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Phenobarbital; Time Factors | 1973 |
Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.
Topics: Aminopyrine N-Demethylase; Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Diet; Enzyme Induction; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen; Oxidoreductases; Phenobarbital; Rats; Riboflavin Deficiency | 1973 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium | 1973 |
Electron transport components of hepatic microsomes. Solubilization, resolution, and recombination to reconstitute aniline hydroxylase activity.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Chloromercuribenzoates; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats; Solubility; Structure-Activity Relationship; Vitamin K | 1973 |
Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction.
Topics: Aminopyrine; Animals; Azides; Catalase; Cytochrome P-450 Enzyme System; Hemeproteins; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1973 |
Lipid peroxidation and the degradation of cytochrome P-450 heme.
Topics: Aminopyrine; Animals; Benzopyrenes; Benzphetamine; Carbon Monoxide; Chromatography, Paper; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; Levulinic Acids; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Pentobarbital; Peroxidases; Phenobarbital; Protein Binding; Rats; Secobarbital; Spectrophotometry; Time Factors; Tritium | 1973 |
Preparation of partially purified, lipid-depleted cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase from rat liver microsomes.
Topics: Animals; Cholic Acids; Chromatography, DEAE-Cellulose; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Detergents; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Rats; Spectrophotometry; Ultrafiltration | 1974 |
The effects of pretreatment of mice with norethindrone on the metabolism of 14C-imipramine by the liver microsomal drug-metabolizing enzymes.
Topics: Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cobalt; Cytochrome c Group; Cytochrome Reductases; Dealkylation; Desipramine; Female; Hydrogen-Ion Concentration; Hydroxylation; Imipramine; Methylcholanthrene; Mice; Microsomes, Liver; NADP; Norethindrone; Oxides; Phenobarbital; Proadifen; Time Factors | 1974 |
Effects of an epoxide hydrase inhibitor on in vivo binding of polycyclic hydrocarbons to DNA and on skin carcinogenesis.
Topics: Administration, Topical; Animals; Benzopyrenes; Chemical Phenomena; Chemistry; DNA; Drug Synergism; Ethers, Cyclic; Hydro-Lyases; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; NADP; Neoplasms, Experimental; Skin; Skin Neoplasms | 1974 |
Factors influencing the microsomal metabolism of 3H-reserpine.
Topics: Animals; Benzoates; Biotransformation; Carbon Monoxide; Cats; Chromatography, Thin Layer; Depression, Chemical; Dogs; Enzyme Induction; Female; Formaldehyde; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADH, NADPH Oxidoreductases; NADP; Phenobarbital; Proadifen; Rats; Reserpine; Stimulation, Chemical; Temperature | 1974 |
Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.
Topics: Aflatoxins; Aminopyrine; Animals; Anthracenes; Base Sequence; Benzopyrenes; Biological Assay; Biphenyl Compounds; Carcinogens; DNA, Bacterial; Fluorenes; Humans; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Mutation; NADP; Rats; Salmonella typhimurium; Stilbenes | 1973 |
3-Methylcholanthrene-inducible binding of aromatic hydrocarbons to DNA in purified rat liver nuclei.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Benzopyrenes; Binding Sites; Carbon Radioisotopes; Cell Nucleus; DNA; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Pancreas; Rats; Ribonucleases; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Time Factors | 1974 |
Studies of the binding of sulfur released in the mixed-function oxidase-catalyzed metabolism of diethyl p-nitrophenyl phosphorothionate(parathion) to diethyl p-nitrophenyl phosphate (paraoxon).
Topics: Animals; Benzphetamine; Carbon Monoxide; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Dealkylation; Esterases; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Paraoxon; Parathion; Phenobarbital; Solvents; Sulfur; Sulfur Radioisotopes | 1974 |
[Role of enzymatic phospholipid peroxidation in the mechanism of endoplasmic reticulum membrane uncoupling in vivo].
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Endoplasmic Reticulum; Enzyme Induction; Free Radicals; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phospholipids; Polarography; Rats; Spectrophotometry, Ultraviolet | 1974 |
The interaction of the antineoplastic drug thalicarpine with aniline hydroxylase and microsomal cytochrome of rat liver.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Aporphines; Cell Nucleus; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Cytochromes; DNA; In Vitro Techniques; Isoquinolines; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Rats; RNA; Time Factors | 1974 |
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450.
Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors | 1974 |
Microsome-dependent binding of benzo(alpha)pyrene and aflatoxin B1 to DNA, and benzo(alpha)pyrene binding to aflatoxin-conjugated DNA.
Topics: Aflatoxins; Animals; Benzopyrans; Benzopyrenes; Binding Sites; Carbon Radioisotopes; DNA; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Spectrum Analysis; Tritium | 1974 |
8,9-Dihydro-8,9-dihydroxybenz(a)anthracene 10,11-oxide: a new type of polycyclic aromatic hydrocarbon metabolite.
Topics: Alkenes; Animals; Benz(a)Anthracenes; Chromatography, Thin Layer; Cytosol; Epoxy Compounds; Ethers, Cyclic; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1974 |
Metabolism of 3,4-benzpyrene in rainbow trout (Salmo gairdneri).
Topics: Animals; Benzopyrenes; Biotransformation; Carbon Monoxide; Gills; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kinetics; Liver; Methylcholanthrene; Mixed Function Oxygenases; Muscles; Myocardium; NADP; Nitrogen; Proteins; Salmonidae; Temperature; Trout | 1974 |
Inhibition of hepatic mixed function oxidase activity by propyl gallate.
Topics: Aging; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Benzphetamine; Cytochrome c Group; Cytochrome P-450 Enzyme Inhibitors; Cytochrome Reductases; Diet; Gallic Acid; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Methyltransferases; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry, Ultraviolet | 1974 |
Nitroreduction of 5-nitrofuran derivatives by rat liver xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Cytochrome c Group; Cytochrome Reductases; Cytosol; Dialysis; Electron Transport; Female; Hydrazines; In Vitro Techniques; Liver; Methylcholanthrene; Microsomes, Liver; Milk; NADP; Nitrofurans; Nitrofurantoin; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Thiazoles; Xanthine Oxidase | 1974 |
Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene.
Topics: Animals; Chlorobenzenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Hydroxylation; Kinetics; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Structure-Activity Relationship | 1974 |
Studies of 3,4-benzpyrene, 3-methylcholanthrene, chlordane, and methyltestosterone as stimulators of hepatic microsomal enzyme systems in the rat.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlordan; In Vitro Techniques; Liver; Methylcholanthrene; Methyltestosterone; Microsomes; Mixed Function Oxygenases; NADP; Oxidoreductases; Rats; Subcellular Fractions; Zoxazolamine | 1966 |
Studies on the mechanism of action of mammalian hepatic azoreductase. II. The effects of phenobarbital and 3-methylcholanthrene on carbon monoxide sensitive and insensitive azoreductase activities.
Topics: Animals; Azo Compounds; Carbon Monoxide; Cytochromes; Female; Lipase; Liver; Methylcholanthrene; Microsomes; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats; Tetrazolium Salts | 1967 |
Hepatic microsomes and drug oxidation.
Topics: Animals; Cytochromes; Endoplasmic Reticulum; Insecticides; Liver; Maryland; Methylcholanthrene; Molecular Biology; NADP; National Library of Medicine (U.S.); Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; RNA, Messenger; Smoking; Steroids; Testosterone; United States | 1968 |
Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Calcium; Carbon Monoxide; Carcinogens; Cricetinae; Culture Techniques; Edetic Acid; Enzyme Induction; Female; Fetus; Fluorescence; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Magnesium; Manganese; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Spectrum Analysis; Trypsin | 1968 |
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Sex Factors; Spectrophotometry; Time Factors; Valerates | 1969 |
Studies on the mechanism of nitro reduction by rat liver.
Topics: Aminobenzoates; Animals; Female; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Oxidoreductases; Oxygen; Phenobarbital; Rats | 1969 |
Oxidative demethylation of N-methylhydrazines by rat liver microsomes.
Topics: Animals; Azo Compounds; Bile Acids and Salts; Carbon Monoxide; Cytochromes; Formaldehyde; Hot Temperature; Hydrazines; In Vitro Techniques; Lipase; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen Consumption; Pancreatic Juice; Phenobarbital; Proadifen; Rats | 1969 |
Differential distribution of cytochrome P-450 and cytochrome P-448 in liver microsomal membranes.
Topics: Animals; Cytochromes; Electron Transport; Electron Transport Complex IV; Male; Membranes; Methylcholanthrene; Microsomes, Liver; NADP; Phosphoric Monoester Hydrolases; Rats; Transferases | 1969 |
Charateristics of induced benzpyrene hydrylase activity in the rat foeto-placental unit.
Topics: Animals; Benzopyrenes; Enzyme Induction; Female; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Mixed Function Oxygenases; NADP; Pregnancy; Rats; Steroids | 1970 |
Nature of the water-soluble metabolites of 7,12-dimethylbenza(a)-anthracene formed by liver microsomes of normal and 3-methylcholanthrene-treated rats.
Topics: Animals; Benz(a)Anthracenes; Carbon Isotopes; Chromatography; Chromatography, Gel; Estradiol; Glucuronidase; Glutathione; Methylcholanthrene; Microsomes, Liver; NADP; Peptide Biosynthesis; Protein Binding; Rats; Sulfhydryl Compounds; Water | 1970 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Binding of dimethylaminoazobenzene metabolites to DNA and proteins. I. In vitor studies on a microsomal dependent system.
Topics: Animals; Binding Sites; Carbon Isotopes; Cattle; Cesium; Chlorides; DNA; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; p-Dimethylaminoazobenzene; Protein Binding; Protein Biosynthesis; Rats; Time Factors | 1970 |
Distruption by carcinogens of the hormone dependent association of membranes with polysomes.
Topics: Animals; Carcinogens; Endoplasmic Reticulum; Enzyme Activation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; p-Dimethylaminoazobenzene; Proadifen; Rats; Ribosomes; RNA; Sulfides | 1971 |
Inability of substrates to alter the carbon monoxide and ethyl isocyanide difference spectra of microsomal hemoprotein.
Topics: Aniline Compounds; Animals; Benzopyrenes; Carbon Monoxide; Chromatography, Thin Layer; Cyanides; Cytochromes; Male; Methylcholanthrene; Microsomes, Liver; NADP; Rats; Spectrophotometry | 1971 |
Human placental hydroxylation of 3,4-benzpyrene during early gestation and at term.
Topics: 17-Ketosteroids; Androstanes; Animals; Benzopyrenes; Cholesterol; Dehydroepiandrosterone; Depression, Chemical; Estradiol; Estrone; Female; Fluorometry; Humans; Kinetics; Labor, Obstetric; Liver; Methylcholanthrene; Methyltestosterone; Mixed Function Oxygenases; NADP; Placenta; Pregnancy; Pregnenolone; Progesterone; Rats; Smoking; Testosterone | 1971 |
Enzymatic reduction of niridazole by rat liver microsomes.
Topics: Aerobiosis; Animals; Anthelmintics; Carbon Monoxide; Chemical Precipitation; Chromatography, Gas; Cytochromes; Guinea Pigs; Hydroxylamines; Imidazoles; Ketones; Lipase; Liver; Male; Mass Spectrometry; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Nitro Compounds; Nitrogen; Oxidation-Reduction; Oxidoreductases; Oxygen; Pancreatic Juice; Phenobarbital; Quaternary Ammonium Compounds; Rabbits; Rats; Species Specificity; Spectrophotometry; Sulfates; Tetrazolium Salts; Thiazoles | 1971 |
Preparation and properties of a solubilized form of cytochrome P-450 from chick embryo liver microsomes.
Topics: Acetamides; Allyl Compounds; Animals; Bacillus subtilis; Carbon Monoxide; Cell Fractionation; Chick Embryo; Cytochromes; Depression, Chemical; Detergents; Etiocholanolone; Female; Flavins; Heme; Ketosteroids; Liver; Methods; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Nitrogen; Oxidoreductases; Peptide Hydrolases; Phenobarbital; Pregnanes; Rats; Solubility; Spectrophotometry; Stimulation, Chemical | 1971 |
Effect of caffeine on hepatic microsomal cytochrome P-450.
Topics: Acetanilides; Adrenalectomy; Animals; Anisoles; Caffeine; Cytochromes; Enzyme Induction; Hydrogen-Ion Concentration; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitriles; Nitrophenols; Oxidoreductases; Phenobarbital; Rats; Spectrophotometry; Sulfites; Time Factors | 1970 |
A comparison of the effects of benzypyrene administration on some hepatic microsomal mixed-function oxidases of rats and mice.
Topics: Aniline Compounds; Animals; Benzopyrenes; Benzphetamine; Cytochromes; Hydrogen-Ion Concentration; Hydroxylation; Kinetics; Light; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NADP; Oxidoreductases; Rats; Rats, Inbred Strains; Spectrum Analysis | 1971 |
The interaction of a fluorescent probe with rat hepatic microsomes.
Topics: Aniline Compounds; Animals; Benzphetamine; Binding Sites; Fluorometry; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Naphthalenes; Oxidoreductases; Phenobarbital; Rats; Sulfites; Sulfonic Acids; Warfarin | 1970 |
Chemical and enzymatic composition of microsomal subfractions from rat liver after treatment with phenobarbital and 3-methylcholanthrene.
Topics: Animals; Cholesterol; Cytochromes; Electron Transport; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Phospholipids; Proteins; Rats; RNA; Spectrum Analysis; Tritium | 1970 |
Influence of 2,4-dichloro-6-phenoxyethyl-amine (DPEA) and -diethylaminoethyl diphenylpropylacetate (SKF-525A) on hepatic microsomal azoreductase activity from phenobarbital or 3-methylcholanthrene induced rats.
Topics: Animals; Azo Compounds; Carbon Monoxide; Chlorine; Cytochromes; Enzyme Activation; Enzyme Induction; Ethylamines; Flavin Mononucleotide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Nitrogen; Oxidoreductases; Phenobarbital; Phenols; Proadifen; Rats; Rats, Inbred Strains; Sulfonamides; Sulfonic Acids | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.
Topics: Animals; Benzopyrenes; Carbon Isotopes; Catalysis; Cytochromes; Dealkylation; Enzyme Induction; Hydroxylation; Lipid Metabolism; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Piperazines; Rats; Testosterone | 1972 |
Immunochemical studies on the role of reduced nicotinamide adenine dinucleotide phosphate-cytochrome c (P-450) reductase in drug oxidation.
Topics: Aminopyrine; Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Dealkylation; Immune Sera; Immunodiffusion; Immunoglobulins; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxidative Phosphorylation; Oxidoreductases; Phenobarbital; Rabbits; Rats | 1971 |
Enzymatic dechlorination. Dechlorination of chloroethanes and propanes in vitro.
Topics: Animals; Benzopyrenes; Carbon Monoxide; Chlorine; Enzyme Induction; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Radioisotopes; Rats; Ultracentrifugation | 1971 |
A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro.
Topics: Animals; Female; Glucosephosphate Dehydrogenase; Glucosephosphates; Histamine H1 Antagonists; Liver; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidoreductases; Phenobarbital; Piperazines; Proteins; Rats; Rats, Inbred Strains; Time Factors; Tritium | 1972 |
Differential acute effects of phenobarbital and 3-methylcholanthrene pretreatment on CCl 4 -induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cytochrome c Group; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidoreductases; Phenobarbital; Proteins; Rats; Time Factors | 1972 |
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. 3. Properties of the reconstituted 3,4-benzypyrene hydroxylase system.
Topics: Ammonium Sulfate; Animals; Benzopyrenes; Bile Acids and Salts; Catalysis; Chemical Precipitation; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Lipids; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; Oxidoreductases; Phenobarbital; Phosphatidylcholines; Rats; Surface-Active Agents | 1972 |
A sensitive radiometric assay of aminopyrine N-demethylation.
Topics: Acetamides; Aminopyrine N-Demethylase; Animals; Carbon Isotopes; Chick Embryo; Colorimetry; Cytochrome P-450 Enzyme System; Dealkylation; Fetus; Formaldehyde; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Kidney; Kinetics; Liver; Lung; Male; Methods; Methylcholanthrene; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Proteins; Rats | 1973 |
3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes; NADP; NADPH-Ferrihemoprotein Reductase; Nephropidae; Pancreas; Pharmaceutical Preparations; Species Specificity; Water Pollutants, Chemical | 1984 |
8 alpha, 9 alpha-Epoxyhexahydrocannabinol formation from delta 8-tetrahydrocannabinol by mouse liver microsomes.
Topics: Animals; Cobalt; Dronabinol; Isomerism; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD; NADP; Phenobarbital | 1982 |
The heterogeneity of arylhydrocarbon hydroxylase in fetal liver microsomes of rats.
Topics: 4-Chloromercuribenzenesulfonate; Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Drug Synergism; Female; Fetus; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Pregnancy; Rats; Rats, Inbred Strains | 1983 |
Activation of 2-amino-6-methyldipyrido[1,2-a:3' ,2' -d]imidazole, a mutagenic pyrolysis product of glutamic acid, to bind to microsomal protein by NADPH-dependent and -independent enzyme systems.
Topics: Animals; Biotransformation; Colon; Fatty Acids; Female; Imidazoles; Intestine, Small; Kinetics; Methylcholanthrene; Microsomes; Microsomes, Liver; NADP; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Binding; Proteins; Rats; Rats, Inbred F344 | 1984 |
Effects of beta-naphthoflavone and 3-methylcholanthrene administered to pregnant rats on steroid metabolism in the isolated basal zone of the placenta.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Fetus; Flavonoids; Maternal-Fetal Exchange; Methylcholanthrene; NADP; Placenta; Pregnancy; Progesterone; Rats | 1984 |
Mechanisms of disassembly of a mixed function oxygenase system in liver endoplasmic reticulum: II. The interrelation between lipid peroxidation and proteolytic degradation of cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Hydrolysis; Kinetics; Lipid Peroxides; Liver; Male; Membranes; Methylcholanthrene; Mixed Function Oxygenases; NADP; Phenobarbital; Rats; Trypsin | 1984 |
7-Ethoxycoumarin O-de-ethylase activity in rat brain microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Brain; Enzyme Induction; Male; Methylcholanthrene; Microsomes; NAD; NADP; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Genetic regulation of NADPH supply in perfused mouse liver. Role of the Ah locus during induction by 3-methylcholanthrene.
Topics: Animals; Genes, Regulator; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; NAD; NADP; Oxidation-Reduction; Perfusion; Species Specificity | 1983 |
Microsomal hydroxylation of 3-methylcholanthrene: analysis by computerized gas chromatography-mass spectrometry.
Topics: Animals; Computers; Gas Chromatography-Mass Spectrometry; Hydroxylation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Oxidation-Reduction; Sterols | 1983 |
Comparative study on oxidation of aromatic compounds by rat liver and rabbit lung microsomes.
Topics: Animals; Energy Metabolism; Hydroxylation; Kinetics; Lung; Methylcholanthrene; Microsomes, Liver; NADP; Naphthalenes; Phenobarbital; Rabbits; Rats | 1982 |
Specific labelling of microsomal proteins by reactive intermediates generated from 2-acetylaminofluorene in vitro.
Topics: 2-Acetylaminofluorene; Animals; Biotransformation; Cytosol; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains | 1981 |
The mechanism of the reductive dehalogenation of polyhalogenated compounds by microsomal cytochrome P450.
Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Hydrocarbons, Halogenated; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1981 |
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences.
Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity | 1980 |
Enhancement by cyanide of aniline p-hydroxylation activity in rat liver microsomes.
Topics: 2,2'-Dipyridyl; Acetone; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cyanides; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxygen; Phenobarbital; Potassium Cyanide; Rats | 1980 |
Comparison of ratios of covalent binding to total metabolism of the pulmonary toxin, 4-ipomeanol, in vitro in pulmonary and hepatic microsomes, and the effects of pretreatments with phenobarbital or 3-methylcholanthrene.
Topics: Alkylating Agents; Animals; Biotransformation; Furans; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; NADP; Phenobarbital; Rats; Terpenes | 1980 |
Inactivation of hepatic cytochrome P-450 by allenic substrates.
Topics: Alkadienes; Animals; Cytochrome P-450 Enzyme Inhibitors; Enzyme Induction; Heme; Male; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Protein Binding; Rats | 1980 |
Enzymic formation of dehydrogenated and hydroxylated metabolites from lysergic acid diethylamide by rat liver microsomes.
Topics: Anaerobiosis; Animals; Biotransformation; Hydroxylation; In Vitro Techniques; Lysergic Acid Diethylamide; Male; Methylcholanthrene; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Different requirement for cytochrome b5 in NADPH-supported O-deethylation of p-nitrophenetole catalyzed by two types of microsomal cytochrome P-450.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes; Cytochromes b5; Kinetics; Methylcholanthrene; Microsomes, Liver; NADP; Nitrobenzenes; Oxidation-Reduction; Phenobarbital; Rats | 1980 |
Immunochemical study on the route of electron transfer from NADH and NADPH to cytochrome P-450 of liver microsomes.
Topics: Animals; Antigen-Antibody Reactions; Cytochrome P-450 Enzyme System; Electron Transport; In Vitro Techniques; Male; Methylcholanthrene; Mice; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Pharmaceutical Preparations; Phenobarbital; Rats | 1980 |
Differential role in lipid peroxidation between rat P450 1A1 and P450 1A2.
Topics: Animals; Benzene Derivatives; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hydrogen Peroxide; Isoenzymes; Kinetics; Lipid Peroxidation; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Rabbits; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tetramethylphenylenediamine | 1993 |
Metabolism of 2-acetylaminofluorene. I. Metabolism in vitro of 2-acetylaminofluorene and 2-acetylaminofluoren-9-one by hepatic enzymes.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cytosol; Female; Hydroxylation; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rabbits; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1993 |
Role of cytochrome b5 in the oxidative metabolism of polychlorinated biphenyls catalyzed by cytochrome P450.
Topics: Animals; Antibodies; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochromes b5; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Polychlorinated Biphenyls; Rats; Rats, Wistar; Xenobiotics | 1996 |
Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA.
Topics: Animals; Benzo(a)pyrene; beta Carotene; Cattle; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Spectrophotometry | 1999 |
Renal metabolism of acrylonitrile to cyanide: in vitro studies.
Topics: Acrylonitrile; Animals; Benzimidazoles; Cyanides; Cytochrome P-450 Enzyme System; Ethanol; Fomepizole; Hydrogen-Ion Concentration; Kidney; Male; Methylcholanthrene; Microsomes; NADP; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Sulfhydryl Compounds; Temperature | 1999 |
Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver.
Topics: Animals; Benzene Derivatives; Benzoquinones; Biotransformation; Carbon Isotopes; Chloranil; Cytosol; Environmental Pollutants; Enzyme Induction; Gas Chromatography-Mass Spectrometry; Horseradish Peroxidase; Hydrogen Peroxide; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; NADP; Pentachlorophenol; Phenobarbital; Quinones; Rats; Species Specificity | 2001 |
Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
Topics: Animals; Benzopyrenes; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; NADP; Phenobarbital; Rats; Rats, Sprague-Dawley; Salmonella typhimurium | 2002 |
THE INFLUENCE OF PHENOBARBITAL ADMINISTRATION UPON THE "SOLUBLE" NADP-REQUIRING ENZYMES IN LIVER.
Topics: Aminopyrine; Benzopyrenes; Citrates; Diphenhydramine; Ethionine; Fluorouracil; Gluconates; Hexosephosphates; Isocitrate Dehydrogenase; Liver; Mercaptopurine; Methylcholanthrene; NADP; Oxidoreductases; Pharmacology; Phenobarbital; Phenylalanine; Rats; Research; Uracil | 1964 |
Effects of 3-methylcholanthrene on oxidized nicotinamide-adenine dinucleotide phosphatedependent dehydrogenases and selected metabolites in perfused rat liver.
Topics: Adenosine Triphosphate; Animals; Female; Isocitrate Dehydrogenase; Liver; Malate Dehydrogenase; Methylcholanthrene; NAD; NADP; Oxidation-Reduction; Oxidoreductases; Perfusion; Phosphogluconate Dehydrogenase; Rats; Rats, Sprague-Dawley | 1980 |