3-methylcholanthrene and metyrapone

3-methylcholanthrene has been researched along with metyrapone in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	55 (90.16)	18.7374
1990's	5 (8.20)	18.2507
2000's	1 (1.64)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Kahl, GF; Kahl, R; Kumaki, K; Nebert, DW	1
Belvedere, G; Cantoni, L; Garattini, S; Mussini, E; Pachecka, J; Salmona, M	1
Boobis, AR; Nebert, DW; Pelkonen, O	1
Greiner, JW; Janss, DH; Malan-Shibley, LB	1
Flemming, K; Gertz, J; Hinkelbein, W; Mull, R	1
Ebel, RE; O'keeffe, DH; Peterson, JA	1
Estabrook, RW; Kawano, S; Werringloer, J	1
Bridges, JW; Chakraborty, J; Shirkey, RS	1
Liakhovich, VV; Tsyrlov, IB	1
Gielen, JE; Kremers, P; Pasleau, F	2
Bridges, JW; McPherson, FJ; Parke, DV	1
Burke, MD; Prough, RA	1
McDonagh, AF; Schmid, R	1
Capdevila, J; Moldéus, P; Orrenius, S; Vadi, H	1
Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM	1
Bray, TM; Chen, GM; Janzen, EG; McCay, PB	1
Fandrey, J; Jelkmann, W; Seydel, FP; Siegers, CP	1
Juchau, MR; Namkung, MJ; Yang, HY	1
Aldern, KA; Harris, SE; Hornsby, PJ	1
Bender, PE; Eckardt, RD; Leonard, TB; Newton, JF; Romano, MC; Straub, KM	1
Hayashi, S; Ishikawa, T; Murakami, K; Noshiro, M; Okuda, K; Shimosato, T	1
Koda, A; Konishi, Y; Mori, Y; Nagai, H; Toyoshi, K; Yamazaki, H	1
Gessner, T; Olson, JR; Wroblewski, VJ	1
Funae, Y; Imaoka, S; Inoue, K	1
Boobis, AR; Davies, DS; Whyte, C	1
Smith, AG; Stewart, FP	1
Bulgheroni, A; Mayer, JM; Meyer, UA; Repond, C; Testa, B	1
Arlotto, MP; Gorski, JR; Klaassen, CD; Parkinson, A	1
O'Brien, PJ; Rahimtula, AD	1
Flemming, K; Gertz, J; Mull, RH	1
Anisimov, VN; Dil'man, VM	1
Ikeda, M; Imamura, T; Otsuji, H	2
Castro, JA; D'Acosta, N; de Castro, CR; de Ferreyra, EC; Díaz Gómez, MI	1
Frommer, U; Ullrich, V; Weber, P	1
Hüthwohl, B; Jonen, HG; Kahl, GF; Kahl, R	1
Jonen, HG; Kahl, GF; Kahl, R	1
Levine, WG	1
Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC	1
Inamori, Y; Ogawa, T; Okamoto, O	1
Ianmori, Y; Ogawa, T; Okamoto, O	1
Dao, TL; Libby, P; Omukai, Y; Tominaga, T	1
Boyland, E; Sims, P	1
Miyauchi, M	1
Kasuya, Y; Kawanishi, T; Ohno, Y; Omori, Y; Takahashi, A; Takanaka, A	1
Razzouk, C; Roberfroid, MB	1
Bassi, AM; Chiarpotto, E; Dianzani, MU; Ferro, M; Marinari, UM; Nanni, G; Poli, G	1
Bryan, AH; Greiner, JW; Janss, DH; Malan-Shibley, LB	1
Cazer, FD; Hart, RW; Sheikh, YM; Witiak, DT	1
DePierre, JW; Meijer, J	1
Belitskiĭ, GA; Kiseleva, MG; Prikhod'ko, AZ	1
Parkinson, A; Robertson, LW; Safe, S	1
Kitagawa, H; Naminohira, S; Saito, H; Sakai, T; Ueno, K	1
Grafstöm, R; Stohs, SJ	1
Hollenberg, PF; Koop, DR	1
Cumps, J; Dumont, P; Luu-The, V	1
Kupfer, D; Mani, C; Parkinson, A; Pearce, R	1
Aniya, Y; Naito, A; Shimoji, M	1
Dhawan, A; Parmar, D; Seth, PK	1
Dusatti, F; Ferro, M; Gelardi, A; Morini, F; Penco, S	1

Reviews

1 review(s) available for 3-methylcholanthrene and metyrapone

Article	Year
The enzymatic formation of bilirubin. Annals of the New York Academy of Sciences, 1975, Apr-15, Volume: 244 Topics: Animals; Benzopyrenes; Bile Pigments; Bilirubin; Cytochrome P-450 Enzyme System; Female; Heme; Humans; Macrophages; Methylcholanthrene; Metyrapone; Microsomes; Organ Specificity; Oxidation-Reduction; Oxygenases; Phenobarbital; Placenta; Pregnancy; Proadifen	1975

Other Studies

60 other study(ies) available for 3-methylcholanthrene and metyrapone

Article	Year
Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes. The Journal of biological chemistry, 1976, Sep-10, Volume: 251, Issue:17 Topics: Animals; Binding Sites; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Genes, Dominant; Hydrogen-Ion Concentration; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mutation; Oxygenases; Phenobarbital; Protein Binding; Protein Conformation; Spectrophotometry	1976
Microsomal styrene mono-oxygenase and styrene epoxide hydrase activities in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1976, Volume: 6, Issue:10 Topics: Animals; Brain; Carbamazepine; Epoxide Hydrolases; Female; Hydro-Lyases; Kidney; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Myocardium; NAD; NADP; Organ Specificity; Oxygenases; Phenobarbital; Proadifen; Rats; Sex Factors; Spleen; Styrenes	1976
Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice. Biochemical pharmacology, 1979, Volume: 28, Issue:1 Topics: Animals; Benzopyrenes; Cyclohexanes; DNA; Enzyme Induction; Enzyme Inhibitors; Ethanol; Flavonoids; In Vitro Techniques; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Species Specificity	1979
Characteristics of aryl hydrocarbon hydroxylase activity in rat mammary epithlial cells grown in primary culture. Chemico-biological interactions, 1979, Volume: 27, Issue:2-3 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzoflavones; Blood; Cells, Cultured; Culture Media; Enzyme Induction; Female; Mammary Glands, Animal; Methylcholanthrene; Metyrapone; Rats	1979
A comparative study on the influence of cysteamine and metyrapone on mixed-function oxygenase activities in variously pretreated liver microsomes from rats and mice. Biochimica et biophysica acta, 1977, Apr-12, Volume: 481, Issue:2 Topics: Acetanilides; Animals; Cysteamine; Disulfides; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Niacinamide; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Rats; Time Factors	1977
Studies of the unique nature of the cytochrome P-450 active site. Electron spin resonance spectroscopy as a probe of the hemin iron of cytochrome P-450: the influence of buffer composition, alcohols, and nitrogenous ligands. Archives of biochemistry and biophysics, 1977, Volume: 183, Issue:1 Topics: Alkanesulfonates; Animals; Binding Sites; Buffers; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Hemin; Male; Membranes; Methanol; Methylcholanthrene; Metyrapone; Microsomes, Liver; Morpholines; Phenobarbital; Pseudomonas; Rats	1977
Spin state transitions of liver microsomal cytochrome P-450. Acta biologica et medica Germanica, 1979, Volume: 38, Issue:2-3 Topics: Animals; Camphor; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone; Protein Binding; Rats; Spectrophotometry	1979
Comparison of the drug metabolising ability of rat intestinal mucosal microsomes with that of liver. Biochemical pharmacology, 1979, Sep-15, Volume: 28, Issue:18 Topics: Animals; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Organ Specificity; Oxidoreductases; Phenobarbital; Proadifen; Rats	1979
[Use of inhibition by metyrapone in a "mutual depletion system" for evaluation of active centres of various arylhydrocarbon hydroxylases]. Biokhimiia (Moscow, Russia), 1979, Volume: 44, Issue:7 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochromes; Kinetics; Male; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Microsomes, Liver; Protein Binding; Species Specificity	1979
Is steroid-16alpha-hydroxylase supported by more than one monooxygenase? Biochemical and biophysical research communications, 1978, Oct-16, Volume: 84, Issue:3 Topics: Animals; Female; Flavonoids; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Naphthalenes; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Sex Factors; Steroid Hydroxylases	1978
The effects of benzopyrene and safrole on biphenyl 2-hydroxylase and other drug-metabolizing enzymes. The Biochemical journal, 1976, Mar-15, Volume: 154, Issue:3 Topics: Acetone; Aniline Hydroxylase; Animals; Benzopyrene Hydroxylase; Benzopyrenes; Catechol Oxidase; Cricetinae; Cytochromes; Dactinomycin; Dioxoles; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nikethamide; Phenobarbital; Rats; Safrole	1976
Some characteristics of hamster liver and lung microsomal aryl hydrocarbon (biphenyl and benzo(a)pyrene) hydroxylation reactions. Biochemical pharmacology, 1976, Oct-01, Volume: 25, Issue:19 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Benzopyrenes; Carbon Monoxide; Cricetinae; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Flavonoids; Lung; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Morphine Derivatives; Naphthalenes; Oxidoreductases, N-Demethylating	1976
The metabolism of benzo(alpha)pyrene in isolated rat liver cells. Cancer research, 1975, Volume: 35, Issue:8 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Cells, Cultured; Flavonoids; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rotenone; Solubility; Stimulation, Chemical	1975
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450. Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00 Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors	1975
The role of mixed function oxidase (MFO) in the metabolism of the spin trapping agent alpha-phenyl-N-tert-butyl-nitrone (PBN) in rats. Free radical research communications, 1991, Volume: 14, Issue:1 Topics: Animals; Cyclic N-Oxides; Enzyme Induction; Kidney; Liver; Lung; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrogen Oxides; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred Strains; Spin Labels	1991
Role of cytochrome P450 in the control of the production of erythropoietin. Life sciences, 1990, Volume: 47, Issue:2 Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoietin; Humans; Liver Neoplasms; Methylcholanthrene; Metyrapone; Microsomes; Oxygen; Phenobarbital; Thyroxine; Triiodothyronine; Tumor Cells, Cultured	1990
Immunodetection, immunoinhibition, immunoquantitation and biochemical analyses of cytochrome P-450IA1 in tissues of the ratoffceptus during the progression of organogenesis. Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22 Topics: 2-Acetylaminofluorene; Amnion; Animals; Benzo(a)pyrene; Benzoflavones; Chorion; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Enzyme Induction; Female; Gestational Age; Immunologic Techniques; Isoenzymes; Methylcholanthrene; Metyrapone; Morphogenesis; Oxazines; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Yolk Sac	1989
Methylcholanthrene: a possible pseudosubstrate for adrenocortical 17 alpha-hydroxylase and aryl hydrocarbon hydroxylase. Biochemical pharmacology, 1986, Oct-01, Volume: 35, Issue:19 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 Enzyme System; Methylcholanthrene; Metyrapone; Protein Biosynthesis; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Steroids; Time Factors	1986
Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases. The Journal of biological chemistry, 1987, Feb-05, Volume: 262, Issue:4 Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Kinetics; Leukotriene B4; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Proadifen; Pyrimidines; Rats; Rats, Inbred F344; Temperature	1987
Aryl hydrocarbon hydroxylase activity in rat submandibular glands. Journal of dental research, 1986, Volume: 65, Issue:1 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Carbon Monoxide; Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; NADH Dehydrogenase; NADPH-Ferrihemoprotein Reductase; Oxygenases; Proadifen; Rats; Rats, Inbred Strains; Submandibular Gland; Time Factors	1986
A comparative study of the mutagenic activation of N-nitrosopropylamines by various animal species and man: evidence for a cytochrome P-450 dependent reaction. Japanese journal of cancer research : Gann, 1986, Volume: 77, Issue:2 Topics: Adult; Aniline Hydroxylase; Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; DNA; Dose-Response Relationship, Drug; Female; Humans; Liver; Macaca fascicularis; Macaca mulatta; Male; Mesocricetus; Methylation; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred Strains; Mutagens; Nitrosamines; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity	1986
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster. Biochemical pharmacology, 1988, Apr-15, Volume: 37, Issue:8 Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity	1988
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. Archives of biochemistry and biophysics, 1988, Aug-15, Volume: 265, Issue:1 Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dipyrone; Female; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains	1988
Selective induction and inhibition of the components of 7-ethoxycoumarin O-deethylase activity in the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1986, Volume: 16, Issue:3 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains	1986
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole	1986
Dual ligand binding of pyridylalkanamides to microsomal cytochrome P-450. Biochemical pharmacology, 1986, Jul-01, Volume: 35, Issue:13 Topics: Animals; Cytochrome P-450 Enzyme System; Male; Mathematics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains; Structure-Activity Relationship	1986
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN). Carcinogenesis, 1985, Volume: 6, Issue:4 Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors	1985
Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450. Biochemical and biophysical research communications, 1974, Sep-09, Volume: 60, Issue:1 Topics: Androstenedione; Aniline Compounds; Animals; Benzopyrenes; Coumarins; Cyanides; Cytochrome P-450 Enzyme System; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Magnesium; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidation-Reduction; Oxygen Consumption; Peroxides; Phenobarbital; Phenols; Phenylenediamines; Proadifen; Rabbits; Rats; Sodium Dodecyl Sulfate; Species Specificity; Superoxide Dismutase; Time Factors	1974
Proceedings: The effect of cysteamine on the microsomal drug metabolism system. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl Topics: Acetanilides; Animals; Biotransformation; Cysteamine; Dealkylation; In Vitro Techniques; Kinetics; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Peroxidases; Pharmaceutical Preparations; Phenobarbital	1974
[Raising the threshold of sensitivity of the hypothalalomo-hypophyseal system to the homeostatic action of estrogens under the influence of carcinogenic substances]. Voprosy onkologii, 1974, Volume: 20, Issue:5 Topics: Adaptation, Physiological; Animals; Anthracenes; Benz(a)Anthracenes; Carcinogens; DDT; Depression, Chemical; Diethylstilbestrol; Drug Interactions; Estrogens; Female; Homeostasis; Hypothalamo-Hypophyseal System; Injections, Intravenous; Injections, Subcutaneous; Methylcholanthrene; Metyrapone; Nitrosamines; Nitroso Compounds; Nitrosourea Compounds; Organ Size; Ovary; Rats; Time Factors	1974
Comparative studies on aniline hydroxylation and p-nitrotoluene hydroxylation by the liver. Japanese journal of pharmacology, 1972, Volume: 22, Issue:4 Topics: Acetamides; Acetone; Aniline Compounds; Animals; Biotransformation; Cricetinae; Depression, Chemical; Guinea Pigs; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mice; Phenobarbital; Pyridines; Rabbits; Rats; Sex Factors; Stimulation, Chemical; Toluene	1972
Comparative studies on hepatic N- and O-demethylation. Japanese journal of pharmacology, 1972, Volume: 22, Issue:4 Topics: Aniline Compounds; Animals; Anisoles; Antipyrine; Benzene; Biotransformation; Depression, Chemical; Ethylamines; Female; Hydroxylation; Kinetics; Liver; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Pyridines; Rats; Stimulation, Chemical; Tolbutamide	1972
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity. Toxicology and applied pharmacology, 1973, Volume: 25, Issue:4 Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxygenases; Phenobarbital; Proadifen; Protein Binding; Pyrazoles; Rats; Sex Factors; Statistics as Topic	1973
Characterisation of cytochrome P-450 species in rat liver microsomes, I. Differences in the O-dealkylation of 7-ethoxycoumarin after pretreatment with phenobarbital and 3-methylcholanthrene. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1973, Volume: 354, Issue:5 Topics: Animals; Coumarins; Cyclohexanes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Ethyl Ethers; Female; Flavins; Hydrogen-Ion Concentration; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors	1973
Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity. Biochemical pharmacology, 1974, Apr-15, Volume: 23, Issue:8 Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Chemical Phenomena; Chemistry; Coenzymes; Cytochrome P-450 Enzyme System; Hydrogen-Ion Concentration; In Vitro Techniques; Ligands; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Pyridines; Rats; Spectrophotometry, Ultraviolet	1974
Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome P-450. Biochemical pharmacology, 1974, Aug-15, Volume: 23, Issue:16 Topics: Alkanes; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydrogen-Ion Concentration; In Vitro Techniques; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Solvents; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors	1974
Biliary excretion of 3-methylcholanthrene as controlled by its metabolism. The Journal of pharmacology and experimental therapeutics, 1972, Volume: 183, Issue:2 Topics: Animals; Benzopyrenes; Bile; Depression, Chemical; Enzyme Induction; Female; Half-Life; Injections, Intravenous; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Organ Size; Phenobarbital; Piperonyl Butoxide; Proadifen; Rats; Stimulation, Chemical; Time Factors; Tritium	1972
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat. Toxicology and applied pharmacology, 1971, Volume: 19, Issue:4 Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors	1971
[Symposium: interrelations among hormones. 4. The adrenal gland: interaction between the adrenal cortex and medulla treated by adrenal cortex inhibitors]. Nihon Naibunpi Gakkai zasshi, 1970, Feb-10, Volume: 45 Topics: Adrenal Glands; Adrenal Medulla; Animals; Benz(a)Anthracenes; Dexamethasone; Methylcholanthrene; Metyrapone; Rats	1970
[Adrenal glands. 4. Relationship between the adrenal cortex and medulla under treatment with several adrenocortical inhibitors]. Nihon Naibunpi Gakkai zasshi, 1970, Volume: 46, Issue:8 Topics: Adrenal Glands; Adrenal Medulla; Animals; Benz(a)Anthracenes; Catecholamines; Corticosterone; Dexamethasone; Hypophysectomy; Immobilization; Male; Methylcholanthrene; Metyrapone; Organ Size; Rats; Stress, Physiological	1970
Effect of polycyclic hydrocarbons on steroid 11 beta-hydroxylase activity of the adrenal in rats. Cancer research, 1968, Volume: 28, Issue:3 Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Corticosterone; Female; Injections, Intraperitoneal; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Rats; Tungsten	1968
The effect of pretreatment with adrenal-protecting compounds on the metabolism of 7,12-dimethylbenz[a]anthracene and related compounds by rat-liver homogenates. The Biochemical journal, 1967, Volume: 104, Issue:2 Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Chromatography, Thin Layer; Drug Antagonism; Enzyme Induction; Fluorescence; Injections, Intraperitoneal; Liver; Male; Methylcholanthrene; Metyrapone; Rats; Spectrophotometry; Ultraviolet Rays	1967
Conversion of procarcinogens to mutagens by the S-9 fraction from the liver of rainbow trout (Salmo gairdneri): inducibility with PCB, 3-methylcholanthrene and phenobarbital and inhibition by metyrapone and alpha-naphthoflavone. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 79, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Anthracenes; Benzo(a)pyrene; Benzoflavones; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mutagenicity Tests; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonidae; Subcellular Fractions; Temperature; Trout	1984
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats. Archives of toxicology, 1984, Volume: 56, Issue:1 Topics: Aminoacetonitrile; Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzoflavones; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Imidazoles; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Monoamine Oxidase; Niacinamide; Oxidoreductases, N-Demethylating; Phenobarbital; Proadifen; Pyrazoles; Rats; Rats, Inbred Strains; Tranylcypromine	1984
Species differences in the biochemical properties of liver microsomal arylamine and arylamide n-hydroxylases. Chemico-biological interactions, 1982, Volume: 41, Issue:2 Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cricetinae; Fluorenes; Isomerism; Male; Methylcholanthrene; Metyrapone; Mice; Miconazole; Microsomes, Liver; Mixed Function Oxygenases; Paraoxon; Rats; Species Specificity; Substrate Specificity	1982
Competition between benzo[a]pyrene and various steroids for cytochrome P-450-dependent rat liver monooxygenases. Chemico-biological interactions, 1981, Mar-15, Volume: 34, Issue:3 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrene Hydroxylase; Benzopyrenes; Binding, Competitive; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnanolone; Progesterone; Rats; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Steroids; Substrate Specificity; Testosterone	1981
Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells. Cell biochemistry and function, 1984, Volume: 2, Issue:4 Topics: Animals; Biotransformation; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Liver Neoplasms, Experimental; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Phenobarbital; Rats; Spectrum Analysis	1984
Aryl hydrocarbon hydroxylase and epoxide hydratase activities: age effects in mammary epithelial cells of Sprague-Dawley rats. Journal of the National Cancer Institute, 1980, Volume: 64, Issue:5 Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Enzyme Induction; Epithelium; Epoxide Hydrolases; Female; Liver; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylcholanthrene; Metyrapone; Polycyclic Compounds; Proadifen; Rats	1980
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites. Biochemical and biophysical research communications, 1980, Apr-14, Volume: 93, Issue:3 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzoflavones; beta-Naphthoflavone; Carbon Disulfide; Flavonoids; Liver; Male; Mass Spectrometry; Methylcholanthrene; Metyrapone; Phenobarbital; Proadifen; Rats; Structure-Activity Relationship	1980
Comparison of trans-stilbene oxide, phenobarbital and 3-methylcholanthrene as inducers of steroid metabolism by the rat liver microsomal cytochrome P-450 system. Journal of steroid biochemistry, 1983, Volume: 18, Issue:4 Topics: Androstenedione; Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Inbred Strains; Stilbenes; Testosterone	1983
[Cytochrome P-450 and aryl hydroxylase activity in cells of a long-term transplantable tumor]. Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:7 Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Male; Methylcholanthrene; Metyrapone; Mice; Microsomes; Neoplasm Transplantation; Neoplasms, Experimental; Oxygenases; Proadifen; Time Factors	1983
Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics. Biochemical pharmacology, 1982, Nov-01, Volume: 31, Issue:21 Topics: Animals; Biphenyl Compounds; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Enzyme Induction; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains	1982
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice. Research communications in chemical pathology and pharmacology, 1981, Volume: 34, Issue:1 Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; Male; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Pregnancy; Proadifen	1981
Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells. Drug and chemical toxicology, 1981, Volume: 4, Issue:2 Topics: Animals; Benzoflavones; Benzopyrenes; Coumarins; Cytochrome P-450 CYP1A1; Female; Intestine, Small; Methylcholanthrene; Metyrapone; Microsomes; Oxidoreductases; Proadifen; Rats; Rats, Inbred Strains; Rotenone	1981
Liver microsomal metabolism of N-methylcarbazole: a probe for induction, inhibition, and species differences. Molecular pharmacology, 1980, Volume: 17, Issue:1 Topics: Animals; Benzoflavones; Carbazoles; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; NAD; NADP; Phenobarbital; Proadifen; Rabbits; Rats; Species Specificity	1980
Metyrapone - reduced cytochrome P-450 complex: a specific method for the determination of the phenobarbital inducible form of rat hepatic microsomal cytochrome P-450. Biochemical and biophysical research communications, 1980, Apr-14, Volume: 93, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Kinetics; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Protein Binding; Rats; Spectrophotometry	1980
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis, 1994, Volume: 15, Issue:12 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin	1994
Increase in liver microsomal glutathione S-transferase activity by phenobarbital treatment of rats. Possible involvement of oxidative activation via cytochrome P450. Biochemical pharmacology, 1993, Nov-17, Volume: 46, Issue:10 Topics: Amitrole; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Ethylmaleimide; Glutathione Peroxidase; Glutathione Transferase; Hydrogen Peroxide; Isoniazid; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley	1993
Evidence for O-dealkylation of 7-pentoxyresorufin by cytochrome P450 2B1/2B2 isoenzymes in brain. Molecular and cellular biochemistry, 1998, Volume: 189, Issue:1-2 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Brain; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Dealkylation; Immunoglobulin G; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Oxazines; Phenobarbital; Rats; Rats, Wistar; Steroid Hydroxylases	1998
Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544. Toxicology in vitro : an international journal published in association with BIBRA, 2001, Volume: 15, Issue:6 Topics: Benzoflavones; beta-Naphthoflavone; Cell Line; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Inactivation, Metabolic; Keratinocytes; Methylcholanthrene; Metyrapone; Oxidoreductases; Phenobarbital; Xenobiotics	2001