3-methylcholanthrene has been researched along with isosafrole in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (56.76) | 18.7374 |
| 1990's | 13 (35.14) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bridges, JW; Dickins, M; Elcombe, CR; Netter, KJ | 1 |
| Horbach, GJ; Kremers, P; Rietjens, IM; Van Asten, JG; Van Bezooijen, CF | 1 |
| Albores, A; Bach, PH; Bridges, JW; Cebrian, ME; Connelly, JC | 1 |
| Hsieh, CY; Huang, JD | 1 |
| Balvers, WG; Boersma, MG; Rietjens, IM; Veeger, C | 1 |
| Hanioka, N; Ishida, C; Koga, N; Saeki, HK; Yoshimura, H | 1 |
| Boobis, AR; Davies, DS; Edwards, RJ; Levin, W; Sesardic, D; Thomas, PE | 1 |
| Boobis, AR; Cole, KJ; Davies, DS; Edwards, RJ; Levin, W; Sesardic, D; Thomas, PE | 1 |
| Clement, B; Kunze, T | 1 |
| Kelley, M; Safe, S; Womack, J | 1 |
| Etoh, H; Misawa, S; Tanaka, E | 1 |
| Gessner, T; Olson, JR; Wroblewski, VJ | 1 |
| Batt, AM; Delatour, P; Masson, C; Mothe, O; Siest, G; Souhaili-El Amri, H; Totis, M | 1 |
| Campanile, C; Haniu, M; Levin, W; Maines, SL; Mendez-Picon, G; Parker, G; Shively, JE; Thomas, PE; Watkins, PB; Wrighton, SA | 1 |
| Smith, AG; Stewart, FP | 1 |
| Degawa, M; Hashimoto, Y; Kojima, M; Sato, Y | 1 |
| Adang, A; Müller, F; van Bladeren, PJ; van Ommen, B | 1 |
| Chen, YT; Ding, JH; Kato, T | 1 |
| Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ | 1 |
| Gonzalez, FJ; Nebert, DW; Tuteja, N | 1 |
| Bark, DH; Greenaway, JC; Juchau, MR; Shewey, LM | 1 |
| Goldstein, JA; Hodgson, E; Linko, P; Yeowell, HN | 1 |
| Bast, A; Kroes, BH; Savenije-Chapel, EM | 1 |
| Levin, W; Reik, LM; Ryan, DE; Thomas, PE | 1 |
| Parkinson, A; Robertson, LW; Safe, SH | 1 |
| Kimura, R; Watanabe, K; Yoshizawa, I | 1 |
| Haniu, M; Levin, W; Ryan, DE; Shively, JE | 1 |
| Jollow, DJ; Longacre, S; Price, V; Roberts, S; Smith, C | 1 |
| Altieri, M; Chen, YT; Ikeda, T; Nakamura, M; Nebert, DW; Negishi, M; Tukey, RH | 1 |
| Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
| Bridges, JW; Fennell, TR; Sweatman, BC | 1 |
| Castell, JV; Donato, MT; Gómez-Lechón, MJ | 1 |
| George, SG; Leaver, MJ; Pirrit, L | 1 |
| Nemoto, N; Sakurai, J | 1 |
| Law, MY; Moody, DE; Slawson, MH | 1 |
| Chen, TT; Lipsky, MM; Råbergh, CM; Vrolijk, NH | 1 |
| Badger, TM; Hakkak, R; Ronis, MJ; Rowlands, JC | 1 |
1 review(s) available for 3-methylcholanthrene and isosafrole
| Article | Year |
|---|---|
Pharmacokinetic considerations in toxicity testing.
Topics: Acetaminophen; Animals; Cricetinae; Drug Interactions; Kinetics; Liver; Methylcholanthrene; Pharmaceutical Preparations; Rats; Receptors, Drug; Safrole; Toxicology | 1982 |
36 other study(ies) available for 3-methylcholanthrene and isosafrole
| Article | Year |
|---|---|
A novel haemoprotein induced by isosafrole pretreatment in the rat.
Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Rats; Safrole; Spectrum Analysis | 1978 |
The effect of age on inducibility of various types of rat liver cytochrome P-450.
Topics: Aging; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methylcholanthrene; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred BN; RNA, Messenger; Safrole | 1992 |
Effects of arsenite on hepatic mixed-function oxidase activity in rats.
Topics: Animals; Arsenic; Arsenites; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Wistar; Safrole | 1992 |
Two-dimensional high-performance liquid chromatographic method to assay p-hydroxyphenylphenylhydantoin enantiomers in biological fluids and stereoselectivity of enzyme induction in phenytoin metabolism.
Topics: Acetone; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cimetidine; Dexamethasone; Diazepam; Enzyme Induction; Female; Ketoconazole; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenytoin; Rats; Safrole; Sex Characteristics; Stereoisomerism; Sulfaphenazole | 1992 |
Differential cumene hydroperoxide sensitivity of cytochrome P-450 enzymes IA1 and IIB1 determined by their way of membrane incorporation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene Derivatives; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis, Polyacrylamide Gel; Kinetics; Lipid Peroxidation; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1992 |
Metabolism in vitro of 3,4,3',4'- and 2,5,2',5'-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450.
Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Pentobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Safrole; Sulfhydryl Compounds | 1991 |
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cyclohexanes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Isoenzymes; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Oxidoreductases; Phenacetin; Rats; Rats, Inbred Strains; Safrole; Substrate Specificity | 1990 |
The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Isoenzymes; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Safrole; Tissue Distribution | 1990 |
Hepatic microsomal N-hydroxylation of adenine to 6-N-hydroxylaminopurine.
Topics: Adenine; Animals; Catalase; Chromatography, High Pressure Liquid; Female; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole; Superoxide Dismutase | 1990 |
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone | 1990 |
The effects of selective cytochrome P-450 inducing agents on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in rats.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Liver; Male; Methylcholanthrene; Oxazoles; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Trimethadione | 1990 |
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity | 1988 |
Albendazole sulfonation by rat liver cytochrome P-450c.
Topics: Albendazole; Animals; Anthelmintics; Aroclors; Benzimidazoles; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Safrole | 1988 |
Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.
Topics: Adult; Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Humans; Immunosorbent Techniques; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Rats; Safrole | 1986 |
Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes.
Topics: Acetylcysteine; Aroclors; Carbon Monoxide; Chlorobenzenes; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Ellipticines; Enzyme Induction; Female; Gas Chromatography-Mass Spectrometry; Glutathione; Hexachlorobenzene; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Molecular Weight; NADP; Pentachlorophenol; Phenobarbital; Polychlorinated Dibenzodioxins; Proadifen; Safrole | 1986 |
Induction of a high spin form of microsomal cytochrome P-448 in rat liver by 4-aminoazobenzene derivatives.
Topics: Animals; Azo Compounds; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A2; Cytochromes; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Microsomes, Liver; p-Aminoazobenzene; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole | 1986 |
The microsomal metabolism of pentachlorophenol and its covalent binding to protein and DNA.
Topics: Animals; Carbon Radioisotopes; Chlorophenols; DNA; Female; Hexachlorobenzene; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Pentachlorophenol; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains; Safrole | 1986 |
Identification and quantification of a messenger ribonucleic acid induced by polynuclear aromatic hydrocarbons--using a cloned human cytochrome P-450 gene.
Topics: Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Carcinogens; Cell Line; Cloning, Molecular; Cytochrome P-450 Enzyme System; Diazonium Compounds; DNA; Electrophoresis, Agar Gel; Genes; Humans; Hydrolases; Lymphocytes; Macaca fascicularis; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Polycyclic Compounds; Protein Biosynthesis; Rabbits; Reticulocytes; RNA, Messenger; Safrole | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromosome Mapping; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dioxins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Induction; Female; Gene Expression Regulation; Genes; Liver; Methylcholanthrene; Mice; Polychlorinated Dibenzodioxins; Pregnancy; Safrole; Steroid Hydroxylases | 1985 |
Generation of reactive dysmorphogenic intermediates by rat embryos in culture: effects of cytochrome P-450 inducers.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Biotransformation; Cells, Cultured; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Embryo, Mammalian; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains; Safrole | 1985 |
Induction of specific cytochrome P-450 isozymes by methylenedioxyphenyl compounds and antagonism by 3-methylcholanthrene.
Topics: Animals; Cell-Free System; Collodion; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxoles; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Immunochemistry; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Polyribosomes; Radioimmunoassay; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1985 |
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Phenobarbital; Ranitidine; Rats; Rats, Inbred Strains; Safrole | 1984 |
Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Immune Sera; Immunodiffusion; Isomerism; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Radioimmunoassay; Rats; Safrole | 1983 |
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1983 |
An induction effect of phenobarbital on rat liver microsomal 4-hydroxylation of estradiol 17-sulfate.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Estradiol; Hydroxylation; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Safrole | 1984 |
Structures of cysteine-containing peptides in isosafrole-inducible rat hepatic microsomal cytochrome P-450d: sequence homology with 3-methylcholanthrene-induced cytochrome P-450c.
Topics: Amino Acid Sequence; Animals; Cysteine; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Fragments; Rats; Safrole; Trypsin | 1984 |
Characterization of cytochrome P2-450 (20-S) mRNA. Association with the P1-450 genomic gene and differential response to the inducers 3-methylcholanthrene and isosafrole.
Topics: Animals; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Female; Gene Expression Regulation; Kidney; Liver; Male; Methylcholanthrene; Mice; Nucleic Acid Hybridization; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole | 1983 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole | 1980 |
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture.
Topics: Adult; Aged; Cells, Cultured; Clofibric Acid; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ethanol; Female; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Middle Aged; Nitrophenols; Oxazines; Oxidation-Reduction; Phenobarbital; Safrole; Substrate Specificity; Testosterone | 1995 |
Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa) and induction of P450 1A1 mRNA in various tissues by 3-methylcholanthrene and isosafrole.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Flounder; Humans; Liver; Methylcholanthrene; Molecular Sequence Data; Organ Specificity; Restriction Mapping; RNA, Messenger; Safrole; Sequence Homology, Amino Acid | 1993 |
Cell-density-dependent expression of Cyp1a2 gene in monolayer-cultured adult mouse hepatocytes.
Topics: Animals; Blotting, Northern; Cell Count; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxidoreductases; Polychlorinated Dibenzodioxins; RNA, Messenger; Safrole; Time Factors | 1993 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |
Differential expression of two CYP1A genes in rainbow trout (Oncorhynchys mykiss).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Blotting, Northern; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Female; Gene Expression Regulation; Liver; Male; Methylcholanthrene; Oncorhynchus mykiss; Polychlorinated Dibenzodioxins; Polymerase Chain Reaction; RNA, Messenger; Safrole; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid | 2000 |
Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood.
Topics: Aging; Animals; Blotting, Northern; Blotting, Western; Caseins; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytosol; Dietary Proteins; Enzyme Induction; Female; Fertilization; Liver; Male; Methylcholanthrene; Milk Proteins; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Safrole; Soybean Proteins; Whey Proteins | 2001 |