3-methylcholanthrene has been researched along with hexobarbital in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krauss, P; Nehls, P; Remmer, H; Synder, R; Witmer, C | 1 |
| Guenthner, TM; Mannering, GJ | 1 |
| Francis, KT; Hamrick, ME | 1 |
| Sato, R; Shimada, T | 1 |
| de Matteis, F; Unseld, A | 1 |
| Elliot, S; Gelboin, HV; Waters, HL; Wiebel, FJ | 1 |
| Takagi, M | 1 |
| Capdevila, J; Moldéus, P; Orrenius, S; Vadi, H | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H; Thomas, JH; Vars, HM | 1 |
| Ioannides, C; Lewis, DF; Parke, DV; Rodrigues, AD | 1 |
| Breimer, DD; de Bree, H; Heij, P; van der Graaff, M; Vermeulen, NP | 1 |
| Cooper, SD; De la Iglesia, FA; Feuer, G; Lumb, G | 1 |
| Gielen, JE; Goujon, FM; Nebert, DW | 1 |
| Kato, R | 2 |
| Estabrook, RW; Greim, H; Remmer, H; Schenkman, J | 1 |
| Greim, G; Hildebrandt, A; Remmer, H | 1 |
| Feuer, G; Granda, V | 1 |
| Gillette, JR; Stripp, B | 1 |
| Baron, J; Estabrook, RW; Ishimura, Y; Peterson, J | 1 |
| Arnold, K; Gerber, N | 1 |
| Gigon, PL; Gillette, JR; Gram, TE | 1 |
| Kato, R; Omori, Y; Onoda, K; Takanaka, A | 1 |
| Gillette, JR | 2 |
| De Matteis, F; Greig, JB | 1 |
| Back, KC; Murphy, JP; Van Stee, EW | 1 |
| Nebert, DW; Robinson, JR | 1 |
| Cinti, DL; Kraschnitz, R; Moldeus, P; Orrenius, S; Schenkman, JB | 1 |
| Fukazawa, H; Kamataki, T; Kitagawa, H | 1 |
| McCarthy, JS; Stitzel, RE | 1 |
| Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC | 1 |
| Orrenius, S; Schenkman, JB; Von Bahr, C; Wilson, B | 1 |
| Arcos, JC; Argus, MF; Venkatesan, N | 1 |
| Brase, DA; Westfall, TC | 1 |
| Kato, R; Takanaka, A | 1 |
| Kato, R; Oshima, T; Takayanagi, M | 1 |
| Furner, RL; Gram, TE; Stitzel, RE | 2 |
| Kato, R; Takanaka, A; Takayanaghi, M | 1 |
| Ankermann, H; Elger, J; Franke, H; Klinger, W; Reinicke, C; Traeger, A; Volkmann, H; Wahrenberg, I | 1 |
| Wilson, JT | 1 |
| Gigon, PL; Gillette, JR; Gram, TE; Greene, FE; Guarino, AM | 1 |
| Greim, H; Remmer, H; Schenkman, JB; Zange, M | 1 |
| Costa, E; Groppetti, A | 1 |
| Chaplin, MD; Mannering, GJ; Shoeman, DW | 1 |
| Anders, MW; Furner, RL; McCarthy, JS; Stitzel, RE | 1 |
| Fouts, JR; Gram, TE; Rogers, LA | 1 |
| Breimer, DD; Langendijk, PN; van der Graaff, M; Vermeulen, NP | 1 |
| Fujimori, K; Inoue, K; Kasuya, Y; Mizokami, K; Omori, Y; Sunouchi, M; Takanaka, A | 1 |
| Sonawane, BR; Witmer, CM; Yaffe, SJ | 1 |
| Drew, R; Grygiel, JJ; Rowell, J | 1 |
| Delaforge, M; Ioannides, C; Parke, DV | 1 |
| CONNEY, AH; JACOBSON, M; KUNTZMAN, R; SCHNEIDMAN, K | 2 |
3 review(s) available for 3-methylcholanthrene and hexobarbital
| Article | Year |
|---|---|
Sex-related differences in drug metabolism.
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Estradiol; Female; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Oxidoreductases, N-Demethylating; Pentobarbital; Pharmaceutical Preparations; Pharmacology; Phenobarbital; Proadifen; Rats; Sex Factors; Spectrophotometry; Spectrophotometry, Ultraviolet; Strychnine; Testosterone | 1974 |
Oxygenated cytochrome P-450 as an intermediate in hydroxylation reactions.
Topics: Aniline Compounds; Blood Proteins; Camphor; Chemistry, Organic; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Electron Transport; Hexobarbital; Hydrogen-Ion Concentration; Hydroxylation; Iron; Methylcholanthrene; Microsomes, Liver; Models, Chemical; Models, Structural; Organic Chemistry Phenomena; Oxidation-Reduction; Phenobarbital; Pseudomonas; Spectrophotometry; Spectrum Analysis | 1972 |
Microsomes, metabolism and toxicity.
Topics: Animals; Barbiturates; Biotransformation; Carbon Tetrachloride; DDT; Enzyme Induction; Female; Hexobarbital; Male; Methylcholanthrene; Mice; Microsomes, Liver; Pesticides; Phenobarbital; Pituitary Hormones, Anterior; Protein Deficiency; Rabbits; Rats; Steroids; Toxicology | 1969 |
53 other study(ies) available for 3-methylcholanthrene and hexobarbital
| Article | Year |
|---|---|
Optical and electron paramagnetic resonance studies of partially purified rabbit liver cytochrome P-450.
Topics: Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Dithionite; Electron Spin Resonance Spectroscopy; Hexobarbital; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rabbits; Spectrum Analysis | 1975 |
Induction of hepatic mono-oxygenase systems of pregnant rats with phenobarbital and 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Binding Sites; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethylmorphine-N-Demethylase; Female; Hemeproteins; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nitriles; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnancy; Progesterone; Rats | 1977 |
Dantrolene inhibition of the hepatic mixed function oxidase system.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Dantrolene; Ethylmorphine-N-Demethylase; Hexobarbital; Hydantoins; Kinetics; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Time Factors | 1979 |
Inhibition of mono-oxygenase activities by 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydrase, in rat liver microsomes.
Topics: Aniline Compounds; Animals; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Hexobarbital; Hydrocarbons, Chlorinated; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1979 |
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine | 1978 |
Effect of 7 8-benzoflavone on the duration of zoxazolamine paralysis and hexobarbital hypnosis in rats.
Topics: Animals; Depression, Chemical; Flavonoids; Hexobarbital; Male; Methylcholanthrene; Paralysis; Phenobarbital; Rats; Sleep; Time Factors; Zoxazolamine | 1976 |
Stimulation of choline incorporation into a membrane fraction of rat liver by barbitals in vitro.
Topics: Animals; Cell Fractionation; Choline; Chromatography, Gel; Cytosol; Hexobarbital; Liver; Membranes; Methylcholanthrene; Phenobarbital; Rats; Time Factors | 1975 |
The metabolism of benzo(alpha)pyrene in isolated rat liver cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrenes; Binding Sites; Cells, Cultured; Flavonoids; Hexobarbital; Kinetics; Liver; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Proadifen; Rats; Rotenone; Solubility; Stimulation, Chemical | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Photochemistry; Polycyclic Compounds; Proadifen; Rats; Spectrum Analysis; Time Factors | 1975 |
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.
Topics: Animals; Antifungal Agents; Cytochrome P-450 Enzyme Inhibitors; Hexobarbital; Imidazoles; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Rats; Rats, Inbred Strains; Safrole | 1987 |
Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats.
Topics: Administration, Oral; Aminopyrine; Animals; Aroclors; Carbon Tetrachloride; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hexobarbital; Isoenzymes; Liver; Male; Metabolic Clearance Rate; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
Microsomal phospholipids and drug action--quantitative biochemical and electron microscopic studies.
Topics: Animals; Carbon Tetrachloride; Choline; Coumarins; Dactinomycin; Endoplasmic Reticulum; Ethanol; Ethionine; Female; Glucose-6-Phosphatase; Hexobarbital; Histocytochemistry; In Vitro Techniques; Male; Methylcholanthrene; Microscopy, Electron; Microsomes, Liver; Nitrosamines; Phenobarbital; Phosphatidylethanolamines; Phospholipases; Phospholipids; Rats | 1972 |
Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexobarbital; Hydroxylation; Kidney; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred NZB; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Polycyclic Compounds; Protein Binding; Pyridines; Spectrophotometry | 1972 |
Reaction of drugs with microsomal liver hydroxylase: its influence on drug action.
Topics: Aniline Compounds; Animals; Antipyrine; Benzopyrenes; Cytochromes; Dicumarol; Electron Transport; Enzyme Induction; Hexobarbital; Kinetics; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Protein Binding; Prothrombin Time | 1968 |
[Spectral properties of cytochrome P450 following induction with phenobarbital, benzopyrene and methylcholanthrene].
Topics: Aniline Compounds; Animals; Benzopyrenes; Cytochromes; Enzyme Induction; Hexobarbital; Liver; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Rabbits; Rats; Spectrophotometry; Stimulation, Chemical | 1968 |
Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat.
Topics: Acetates; Amides; Animals; Carbon Tetrachloride; Coumarins; Drug Antagonism; Enzymes; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Phosphoric Monoester Hydrolases; Rats; Toluene | 1970 |
Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
Topics: Animals; Benzene Derivatives; Benzopyrenes; Cortisone; Cytochrome c Group; Cytochrome P-450 Enzyme System; Dealkylation; Diazepam; Female; Guinea Pigs; Hexobarbital; Hydroxylation; Male; Methylcholanthrene; Mice; Microsomes, Liver; Morphine; Oxidoreductases; Pentylenetetrazole; Pharmaceutical Preparations; Phenobarbital; Rats; Research; Sleep; Spironolactone | 1972 |
The effect of diphenyl-piperazine compounds and other agents on diphenylhydantoin, zoxazolamine and hexobarbital metabolism.
Topics: Animals; Benzopyrenes; Cyclizine; DDT; Diphenhydramine; Endoplasmic Reticulum; Hexobarbital; Humans; Hydroxyzine; Liver; Male; Meclizine; Methylcholanthrene; Mice; Microscopy, Electron; Phenethylamines; Phenobarbital; Phenytoin; Piperazines; Trifluoperazine; Zoxazolamine | 1968 |
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Monoxide; Cytochromes; Ethylamines; Female; Hexobarbital; Imipramine; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Morphinans; NADP; Niacinamide; Oxidation-Reduction; Proadifen; Rats; Sex Factors; Spectrophotometry; Time Factors; Valerates | 1969 |
Different effect of aflatoxin on the induction of tryptophan oxygenase and of microsomal drug-hydroxylase system.
Topics: Aflatoxins; Animals; Cytochromes; Enzyme Induction; Female; Hexobarbital; Hydrocortisone; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rats; Tryptophan Oxygenase; Tyrosine Transaminase; Zoxazolamine | 1970 |
Effect of various inducers on electron transport system associated with drug metabolism by liver microsomes.
Topics: Animals; Cytochromes; Electron Transport; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Morpholines; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Phenobarbital; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.
Topics: Administration, Oral; Animals; Barbiturates; Chlorobenzenes; Cytochrome P-450 Enzyme System; Depression, Chemical; Dioxins; Ethionine; Female; Hexobarbital; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Rats; Sleep; Spectrophotometry; Stimulation, Chemical; Zoxazolamine | 1973 |
Effect of dibromotetrafluoroethane inhalation on hepatic drug metabolism in mice.
Topics: Animals; Chlorofluorocarbons, Methane; Drug Interactions; Hexobarbital; Hydrocarbons, Halogenated; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Paralysis; Phenobarbital; Proadifen; Respiration; Sleep; Time Factors; Zoxazolamine | 1973 |
Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism.
Topics: Animals; Benzopyrenes; Carbon Radioisotopes; Crosses, Genetic; Flavonoids; Hexobarbital; Hydrocarbons; Liver; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Molecular Biology; Phenytoin; Sleep; Time Factors; Zoxazolamine | 1974 |
The nature of the reverse type I (modified type II) spectral change in liver microsomes.
Topics: Alcohols; Aminopyrine; Aniline Compounds; Animals; Benzopyrenes; Binding Sites; Carbon Monoxide; Cytochrome P-450 Enzyme System; Drug Synergism; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases; Phenacetin; Rabbits; Rats; Species Specificity; Spectrophotometry; Spectrophotometry, Ultraviolet | 1972 |
[Studies on the hexobarbital difference spectrum with microsomes from 3-methylcholanthrene treated rats].
Topics: Animals; Cytochromes; Hexobarbital; Methylcholanthrene; Microsomes, Liver; Pigments, Biological; Protein Binding; Rats; Spectrophotometry | 1971 |
Kinetic differences in the microsomal metabolism of the isomers of hexobarbital.
Topics: Animals; Enzyme Induction; Hexobarbital; Kinetics; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rabbits; Rats; Stereoisomerism; Time Factors | 1971 |
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1971 |
The significance of drug-induced spectral changes in liver microsomal fraction.
Topics: Animals; Binding Sites; Cytochromes; Hexobarbital; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Nortriptyline; Oxidoreductases; Phenacetin; Rabbits; Spectrum Analysis | 1971 |
Induction and repression of microsomal drug-metabolizing enzymes by polycyclic hydrocarbons and phenobarbital: theoretical models.
Topics: Allosteric Regulation; Animals; Benz(a)Anthracenes; Benzopyrenes; Chlordan; Enzyme Induction; Enzyme Repression; Ethionine; Fluorenes; Genes, Regulator; Hexobarbital; Meperidine; Methylcholanthrene; Microsomes, Liver; Models, Biological; Operon; Oxidoreductases; Phenobarbital; Rats; Zoxazolamine | 1971 |
Studies on the mechanism of tolerance to nicotine-induced elevations of urinary catecholamines.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Catechol O-Methyltransferase; Catecholamines; Catechols; Drug Tolerance; Enzyme Induction; Fluorometry; Heart; Hexobarbital; In Vitro Techniques; Liver; Male; Metabolism; Methylcholanthrene; Methyltransferases; Monoamine Oxidase; Myocardium; Nerve Endings; Nicotine; Norepinephrine; Oxidoreductases; Perfusion; Phenobarbital; Rats; S-Adenosylmethionine; Sleep; Time Factors; Tritium; Zoxazolamine | 1971 |
Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver.
Topics: Aminopyrine; Aniline Compounds; Animals; Blood Proteins; Brain; Brain Chemistry; Cytochromes; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Nitrobenzenes; Pentobarbital; Phenobarbital; Pigments, Biological; Rats; Spectrophotometry; Triazoles; Zoxazolamine | 1967 |
Effect of phenobarbital and methylcholanthrene treatment on drug-induced difference spectrum of liver microsomes.
Topics: Aniline Compounds; Animals; Cytochromes; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Phenobarbital; Rats; Spectrophotometry | 1969 |
Differences in the oxidative metabolism of drugs by liver microsomes.
Topics: Aminopyrine; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Oxidation-Reduction; Oxidoreductases; Pentobarbital; Phenobarbital; Proadifen; Rats; Sex Factors; Starvation; Thyroxine; Zoxazolamine | 1969 |
Factors affecting the metabolism and response to hexobarbital.
Topics: Age Factors; Animals; Body Weight; Breeding; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Rats; Sex Factors; Sleep; Species Specificity; Time Factors | 1969 |
Substrate-induced spectral change of liver microsomes in phenobarbital and methylcholanthrene-treated male and female rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Chemical Phenomena; Chemistry; Female; Hexobarbital; Male; Meperidine; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidation-Reduction; Phenobarbital; Proteins; Rats; Spectrophotometry; Spectrum Analysis; Zoxazolamine | 1970 |
[Studies on the mechanism of enzyme induction. XV. Induction pattern and submicroscopic changes in the liver following application of phenylbutazone in rats of different ages].
Topics: Age Factors; Aminopyrine; Animals; Animals, Newborn; Ascorbic Acid; Cholestasis; Endoplasmic Reticulum; Enzyme Induction; Female; Fetus; Hexobarbital; Liver; Lysosomes; Male; Methylcholanthrene; Microscopy, Electron; Mitochondria, Liver; Phenylbutazone; Pregnancy; Rats | 1970 |
Hepatic drug metabolism after phenobarbital or 3-methylcholanthrene pretreatment of rats bearing a pituitary tumor.
Topics: Aminopyrine; Animals; Benzopyrenes; Hexobarbital; Liver; Male; Methylcholanthrene; Phenobarbital; Pituitary Neoplasms; Rats; Zoxazolamine | 1968 |
Effect of partial hepatectomy of the responsiveness of microsomal enzymes and cytochrome P-450 to phenobarbital or 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Cytochromes; Enzyme Induction; Hepatectomy; Hexobarbital; Liver; Liver Regeneration; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Organ Size; Phenobarbital; Proteins; Rats | 1968 |
On the problem of possible other forms of cytochrome P450 in liver microsomes.
Topics: Animals; Benzopyrenes; Cytochromes; Female; Hexobarbital; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Protein Binding; Rabbits; Rats; Spectrum Analysis | 1969 |
Factors affecting the rate of disappearance of amphetamine in rats.
Topics: Age Factors; Animals; Dextroamphetamine; Estradiol; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Microsomes; Mixed Function Oxygenases; Phenobarbital; Phenytoin; Rats; Sex Factors; Time Factors; Zoxazolamine | 1969 |
Induction of drug metabolism. 3. Further information of a new P-450 hemoprotein after treatment of rats with 3-methylcholanthrene.
Topics: Aniline Compounds; Animals; Binding Sites; Blood Proteins; Cold Temperature; Cytochromes; Hexobarbital; Lipase; Liver; Male; Methylcholanthrene; Microsomes; Phenobarbital; Protein Binding; Proteins; Rats | 1969 |
The influence of age, sex and drug treatment on microsomal drug metabolism in four rat strains.
Topics: Age Factors; Aniline Compounds; Animals; Female; Hexobarbital; Liver; Male; Methylcholanthrene; Mice; Microsomes; Morphine; Phenobarbital; Proteins; Rabbits; Rats; Sex Factors; Species Specificity | 1969 |
Stereoselective metabolism of the enantiomers of hexobarbital.
Topics: Animals; Female; Hexobarbital; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Sex Factors; Sleep; Stereoisomerism; Time Factors | 1969 |
Effect of pretreatment of rabbits with phenobarbital or 3-methylcholanthrene on the distribution of drug-metabolizing enzyme activity in subfractions of hepatic microsomes.
Topics: Aminopyrine; Amphetamine; Animals; Benzopyrenes; Codeine; Hexobarbital; Liver; Male; Methylcholanthrene; Microscopy, Electron; Microsomes; Mixed Function Oxygenases; Phenobarbital; Pigments, Biological; Rabbits; Zoxazolamine | 1967 |
Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies.
Topics: Animals; Barbiturates; Drug Interactions; Half-Life; Hexobarbital; Kinetics; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Comparison of hepatic drug-metabolizing enzymes induced by 3-methylcholanthrene and phenobarbital between pre- and postnatal rats.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Gestational Age; Hexobarbital; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
Effects of endotoxin upon rat hepatic microsomal drug metabolism in vivo and in vitro.
Topics: Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endotoxins; Enzyme Induction; Female; Hexobarbital; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Rats; Sleep | 1982 |
Cimetidine: a specific inhibitor of hepatic aryl hydrocarbon hydroxylase (AHH) in the rat.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cimetidine; Guanidines; Hexobarbital; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats; Sleep | 1981 |
Inhibition of cytochrome P-448 mixed function oxidase activity following administration of 9-hydroxyellipticine to rats.
Topics: Alkaloids; Aniline Compounds; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Rats | 1980 |
FACTORS THAT AFFECT THE STIMULATION OF THE MICROSOMAL DRUG ENZYMES INDUCED BY FOREIGN COMPOUNDS.
Topics: Acetanilides; Adrenocorticotropic Hormone; Benzopyrenes; Hexobarbital; Liver; Methylcholanthrene; Methyltestosterone; Microsomes; Nandrolone; Pharmacology; Phenobarbital; Pyrazoles; Rats; Research; Testosterone; Zoxazolamine | 1963 |
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES.
Topics: Aging; Animals; Chlordan; Estradiol; Fatty Acids; Hexobarbital; Liver; Methylcholanthrene; Mice; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Pharmacology; Phenobarbital; Proadifen; Rats; Research; Sex; Steroid Hydroxylases; Testosterone | 1964 |
DRUG-INDUCED CHANGES IN STEROID METABOLISM.
Topics: Androsterone; Chromatography; Corticosterone; Cortisone; Dogs; Estradiol; Hexobarbital; Histamine H1 Antagonists; Hydrocortisone; Liver; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Phenylbutazone; Piperazines; Rats; Research; Steroids; Testosterone; Toxicology | 1965 |