3-methylcholanthrene has been researched along with benzo(a)pyrene in 257 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 162 (63.04) | 18.7374 |
| 1990's | 59 (22.96) | 18.2507 |
| 2000's | 25 (9.73) | 29.6817 |
| 2010's | 11 (4.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barton, HA; Boulu, LG; Crippen, GM; Kwon, H; Marletta, MA | 1 |
| Corlu, A; Fardel, O; Guillouzo, A; Lecureur, V | 1 |
| Novikov, KN; Sumbalova, Z; Timofeev, KN | 1 |
| Lesca, P; Peryt, B; Szymczyk, T | 1 |
| Baird, S; Bock, KW; Burchell, B; Gschaidmeier, H; Seidel, A | 1 |
| Benfield, JR; Hammond, WG | 1 |
| Krishna, TP; Krishnaswamy, K; Polasa, K; Sesikaran, B | 1 |
| Radike, M; Reilman, R; Schneider, J; Wan, LP; Warshawsky, D; Xue, WL | 1 |
| Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD | 1 |
| Colacci, A; Grilli, S; Perocco, P; Santucci, MA; Vaccari, M | 1 |
| Brauze, D; Pawlak, AL; Wielgosz, SM | 1 |
| Bresnick, E; Houser, WH; Raha, A; Reddy, V; Xu, LC | 1 |
| Adrianov, NV; Archakov, AI; Dovgiĭ, AI; Kuong, DD; Varenitsa, AI | 1 |
| Castegnaro, M; Chambon, P; Chambon, R; Fouillet, B; Weill, N | 1 |
| Ersing, N; Faletto, MB; Gurtoo, HL; Kouli, F; Maccubbin, AE; Vangalio, JA | 1 |
| Eriksson, LC; Ritter, E | 1 |
| Holder, GM; Ryan, AJ | 1 |
| Lamartiniere, CA; Moore, SM | 1 |
| Brauze, D; Mikstacka, R | 1 |
| Belitsky, GA; Budunova, IV; Mittelman, LA | 1 |
| Elias, R; Nagabhushan, M; Ng, YK; Polverini, PJ; Solt, DB | 1 |
| Penn, A | 1 |
| Majeska, JB; Matheson, DW | 1 |
| Cikryt, P; Wiebel, FJ | 1 |
| Alworth, WL; Grover, PL; Hall, M; Hopkins, NE; Lu, JY; Parker, DK | 1 |
| Antignac, E; Cassand, P; Grolier, P; Koch, B; Narbonne, JF | 1 |
| Ong, T; Stewart, JD; Whong, WZ | 1 |
| Aardema, MJ; Gibson, DP; Kerckaert, GA; LeBoeuf, RA | 1 |
| Bresnick, E; Xu, LC | 1 |
| Crouch, LS; Ebel, RE | 2 |
| Al-Turk, WA; Hassing, JM; Stohs, SJ | 1 |
| Ioannides, C; Phillipson, CE | 1 |
| Ayrton, AD; Bass, SL; Flatt, PR; Ioannides, C; Trinick, J | 1 |
| Lindquist, BE; Warshawsky, D | 1 |
| Curtis, G; Garland, H; Nesnow, S | 1 |
| Juchau, MR; Namkung, MJ; Yang, HY | 1 |
| Jia, XS | 1 |
| Al-Sabti, K | 1 |
| Leach, MF; Lin, KH; Lindahl, R; Winters, AL | 1 |
| Ren, J | 1 |
| Avadhani, NG; DiGiovanni, J; Niranjan, BG | 1 |
| Christou, M; Dibartolomeis, MJ; Jefcoate, CR | 1 |
| Harper, BL; Legator, MS | 1 |
| Golas, CL; Gordon, SK; Manchester, DK; Okey, AB; Roberts, EA | 1 |
| Chasovnikova, OB; Grishanova, AIu; Liakhovich, VV; Tsyrlov, IB | 1 |
| Fujii, H; Ohmachi, T; Sagami, I; Watanabe, M | 2 |
| Christou, M; Jefcoate, CR; Keller, GM; Pottenger, LH; Wilson, NM | 1 |
| Marino, DJ | 1 |
| Chen, XR; Sun, L; Yu, YN | 1 |
| Chang, K; DiGiovanni, J; Harvey, RG; Sawyer, TW | 1 |
| Bickers, DR; Bik, DP; Das, M; Khan, WA; Mukhtar, H; Wang, ZY | 1 |
| Barrowman, JA; Laher, JM | 1 |
| Dock, L; Eriksson, L; Jernström, B; Martinez, M; Scheu, G; Torndal, UB | 1 |
| Lahmy, S; Salmon, JM; Viallet, P | 1 |
| Fukuhara, M; Ohno, Y; Sunouchi, M; Takanaka, A | 1 |
| Goertz, MP; Jongen, WM; Sandker, GW; Topp, RJ; van Bladeren, PJ | 1 |
| Bresnick, E; Houser, WH; Siegel, LI | 1 |
| Mureşan, Z; Stafidov, N; Stoica, A; Voiculetz, N | 1 |
| Cavalieri, E; Cremonesi, P; Higginbotham, S; Rogan, E; Salmasi, S | 1 |
| Gessner, T; Olson, JR; Wroblewski, VJ | 1 |
| Csaba, G; Dobozy, O; Szeberényi, S | 1 |
| Mushtaq, M; Weems, HB; Yang, SK | 1 |
| Burnham, DK; Daynes, RA; Gahring, LC | 1 |
| Babish, JG; Brooks, BA; Wassom, DL | 1 |
| Conney, AH | 1 |
| Jacobs, MM; Prasanna, P; Yang, SK | 1 |
| Duzhak, TG; Liakhovich, VV; Tsyrlov, IB | 1 |
| Benediktova, SA; Devichenskiĭ, VM; Izotov, MV; Lugovaia, LV; Shcherbakov, VM | 1 |
| Angeli, G; Monarca, S; Pasquini, R; Savino, A; Scassellati Sforzolini, G | 1 |
| Casciano, DA; Chou, MW; Fu, PP; Hass, BS; Heflich, RH; Schol, HM | 1 |
| Cavalieri, E; Rogan, E; Wong, AK | 1 |
| Liakhovich, VV; Mishin, VM; Mishina, DV | 2 |
| Bogdanffy, MS; Brown, DR; Roberts, AE; Schatz, RA | 1 |
| Chang, RL; Conney, AH; Huang, MT; Jerina, DM; Sayer, JM; Smart, RC; Wood, AW | 1 |
| Grover, PL; Hall, M | 1 |
| Chiu, PL; Yang, SK | 1 |
| Brookes, P; King, HW; Osborne, MR | 1 |
| Hirao, F; Yoshimoto, T | 1 |
| Edelman, AS; Sanchez, P; Thorbecke, GJ; Xue, B | 1 |
| Gustafsson, JA; Poellinger, L; Söderkvist, P | 1 |
| Kandaswami, C; O'Brien, PJ; Rahimtula, M | 1 |
| Das, M; Mukhtar, H; Seth, PK; Srivastava, SP | 1 |
| Wang, CX; Watanabe, K; Weisburger, JH; Williams, GM | 1 |
| Biondi, I; Masi, C; Masucci, MT; Pagnotta, R; Pulcini, D; Sica, V | 1 |
| Guliaeva, LF; Liakhovich, VV; Mishin, VM | 1 |
| Karamysheva, AF; Kobliakov, VA; Sergeev, BL | 1 |
| Jones, PA; Wilson, VL | 1 |
| Kikuchi, H; Watanabe, M | 1 |
| Godden, PM; Ioannides, C; Lum, PY; Parke, DV; Phillipson, CE | 1 |
| Bickers, DR; Cherniack, AD; Cherniack, EP; Das, M; Del Tito, BJ; Mukhtar, H | 1 |
| Uzunov, P; Vlasov, V | 1 |
| Bull, R; Laurie, D; Revis, NW; Schiller, CA | 1 |
| Hänninen, O; Nousiainen, U; Törrönen, R | 2 |
| Cortesi, E; Donovan, PJ; Kakunaga, T; Rice, JM; Saffiotti, U | 1 |
| James, MO; Little, PJ | 1 |
| Schoor, WP; Srivastava, M | 1 |
| Melius, P; Swain, L | 1 |
| Miyauchi, M | 1 |
| Fujino, T; Gelboin, HV; Guengerich, FP; Park, SS; West, D | 1 |
| Epstein, N; Knight, R; Morgan, K; Schor, NA | 1 |
| Heimann, R; Rice, RH | 1 |
| Hietanem, E | 1 |
| Bronczyk, S; Ghadirian, P; Mirvish, SS; Raha, C; Sams, JP; Wallcave, L | 1 |
| Black, O; Fanska, C; Murrill, E | 1 |
| Fahl, WE; Gill, K; Scarpelli, DG | 1 |
| Wang, IY | 1 |
| Lewis, KF; Martin, MB; Sydor, W; Yang, CS | 1 |
| Das, M; Mukhtar, H; Seth, PK | 1 |
| Evans, CH; McCabe, RP; Ohanian, SH | 1 |
| Benfield, JR; Cohen, AH; Fu, PC; Hammond, WG; Jensen, T; Pak, HY; Paladugu, RR; Shors, EC; Teplitz, RL | 1 |
| Dock, L; Jernström, B; Moldéus, P; Nordenskjöld, M; Söderhäll, S; Svensson, SA | 1 |
| Ioannides, C; Parke, DV; Parkinson, C | 1 |
| Dehnen, W; Verbücheln, J | 1 |
| Malejka-Giganti, D; Ritter, CL | 1 |
| Kauffman, FC; McManus, P; Reinke, LA; Thurman, RG | 1 |
| Gelboin, HV; Gozukara, EM; Guengerich, FP; Miller, H | 1 |
| Bickers, DR; Dixit, R; Mukhtar, H | 1 |
| Hendley, R; Williams, MT | 1 |
| Diala, ES; Hoffman, RM | 1 |
| Kocan, RM; Landolt, ML; Sabo, KM | 1 |
| Cheung, HT; Holder, GM; Ireland, CM; Ryan, AJ | 1 |
| Fahl, WE; Jefcoate, CR; Shinnick, FL; Wrighton, SA | 1 |
| Bock, KW; Bock-Hennig, BS; Lilienblum, W; Pfeil, H; Volp, RF | 1 |
| Ball, LM; Bend, JR; Devereux, TR; Fouts, JR; Philpot, RM; Plummer, JL; Smith, BR; Wolf, CR | 1 |
| Guenthner, TM; Oesch, F | 1 |
| Balk, L; Depierre, JW; Rannug, U; Sundvall, A | 1 |
| Boutwell, RK; DiGiovanni, J; Rymer, J; Slaga, TJ | 1 |
| Boutwell, RK; Conrad, EA; Verma, AK | 1 |
| Razzouk, C; Roberfroid, MB | 1 |
| Kochhar, TS | 1 |
| Soyka, LF | 1 |
| de Jong, P; Van Leeuwen, FX; Vos, JG | 1 |
| Mal'tsev, EV | 1 |
| Vlasov, V | 1 |
| Jefcoate, CR; Keller, GM; Turner, CR | 1 |
| Bymun, EN; Shu, HP | 1 |
| Columelli, S; Dansette, P; Leroux, JP; Mahu, JL; Rouer, E | 1 |
| Lau, PP; Lu, AY; Pickett, CB; Strobel, HW | 1 |
| Arfellini, G; Capucci, A; Grilli, MP; Prodi, G; Rocchi, P | 1 |
| Roth, RA; Wiersma, DA | 2 |
| Carlson, GP; White, JF | 1 |
| Hänninen, OO; Laaksonen, AM; Mäntyjärvi, RA | 1 |
| Jergil, B; Schelin, C; Tunek, A | 1 |
| Faustman-Watts, E; Juchau, MR; Namkung, MJ | 1 |
| Abe, T; Watanabe, M | 1 |
| Benrekassa, J; Decloitre, F | 1 |
| Abdel-Tawab, GA; El-Bassiouni, EA; El-Sebae, AH; El-Sewedy, SM; El-Zoghby, SM; Mostafa, MH; Ramadan, M | 1 |
| Abe, S; Nemoto, N; Sasaki, M | 1 |
| Caveness, MB; Goldstein, JA; Sundheimer, DW | 1 |
| Grunberger, D; Huberman, E; Jones, CA; Santella, RM; Selkirk, JK | 1 |
| Gillner, M; Gustafsson, JA; Hansson, LA; Lund, J; Poellinger, L | 1 |
| Dively, C; Gallagher, MM; Kiss, E; Kouri, RE; Lubet, RA; Schechtman, LM | 1 |
| Bynum, G; Dean, RG; Hadley, E; Jacobson-Kram, D | 1 |
| Decker, RW; Malejka-Giganti, D; Ritter, CL | 1 |
| Ali, B; Kaur, S | 1 |
| Gurtoo, HL; Raina, V; Williams, CJ | 1 |
| Agrawal, HP; Randerath, E; Randerath, K; Reddy, MV | 1 |
| Shertzer, HG | 1 |
| Endou, H | 1 |
| Barbacid, M; DiPaolo, JA; Doniger, J; Evans, CH; Pulciani, S; Sukumar, S; Zbar, B | 1 |
| Ryan, AJ; Stupans, I | 1 |
| Bickers, DR; Das, M; Del Tito, BJ; Mukhtar, H | 2 |
| Grover, PL; Hewer, A; Hodgson, RM; Phillips, DH | 1 |
| Fujimori, K; Inoue, K; Kasuya, Y; Mizokami, K; Omori, Y; Sunouchi, M; Takanaka, A | 1 |
| Grishanova, AIu; Gutkina, NI; Liakhovich, VV; Makarova, SI; Mishin, VM | 1 |
| Li, XC; Yang, SK | 1 |
| Anderson, J; Bruner, RH; Kinkead, ER; MacEwen, JD; Rasmussen, RE | 1 |
| Alfred, LJ; Attarzadeh, M; Wojdani, A; Wolde-Tsadik, G | 1 |
| Mishin, VM; Mishina, DV | 1 |
| Acero, R; Alessio, G; Donati, MB; Guarini, A; Mantovani, A; Semeraro, N | 1 |
| Christou, M; Jefcoate, CR; Turner, CR; Wilson, NM; Wrighton, SA | 1 |
| Grishanova, AIu; Liakhovich, VV; Mishin, VM | 1 |
| Jefcoate, CR; Keller, GM | 1 |
| Bingham, E; Niemeier, RW; Warshawsky, D | 1 |
| Cerniglia, CE | 1 |
| Baker, MT; Bunce, OR; Harley, W; Holmes, D; Wade, AE | 1 |
| Lin, KH; Lindahl, R; Winters, AL | 1 |
| Roth, RA; Stemmer, PM; Wiersma, DA | 1 |
| Benfield, JR; Hammond, WG; Pak, HY; Paladugu, R; Shors, EC; Teplitz, RL | 1 |
| Bend, JR; James, MO; Little, PJ; Pritchard, JB | 1 |
| Gasiorowski, K; Szyba, K; Urban, J | 1 |
| Baan, RA; Roggeband, R; Van den Berg, PT; Van der Wulp, CJ | 1 |
| Ueng, TH; Ueng, YF | 1 |
| Benfield, JR; Hammond, WG; Tesluk, H | 1 |
| Fort, FL; Fujikawa, K; Sakamoto, Y; Samejima, K | 1 |
| Abdel-Razzak, Z; Campion, JP; Corcos, L; Fautrel, A; Guillouzo, A | 1 |
| Bjelogrlic, N; Gelboin, HV; Honkakoski, P; Park, SS; Pelkonen, O; Peng, R; Vähäkangas, K | 1 |
| Albrecht, JH; Cherwitz, DL; Erickson, RR; Gelboin, HV; Holtzman, JL; Krueger, MA; Park, SS; Thirman, MJ | 1 |
| Galati, AJ; Jeffers, AJ; Mass, MJ; Nelson, G; Nesnow, S; Ross, JA; Stoner, GD | 1 |
| Gold, A; Nesnow, S; Sangaiah, R; Slaga, TJ | 1 |
| Nesnow, S; Ross, JA | 1 |
| Benfield, JR; Hammond, WG; Teplitz, RL | 1 |
| Ball, LM; Beck, S; Gold, A; Nesnow, S; Sangaiah, R | 1 |
| Chou, MW; Ueng, TH; Ueng, YF | 1 |
| Alvares, AP; Ueng, TH | 1 |
| Leff, T; Rosenberg, DW | 1 |
| Bresnick, E; Sinclair, PR; Xu, LC | 1 |
| Baan, RA; Roggeband, R; Rutten, AA; Wolterbeek, AP | 1 |
| Ferrier, V; Marty, J; Michel, XR; Narbonne, JF | 1 |
| Anderson, LM; Carter, J; Kovatch, RM; Pittinger, S; Riggs, CW; Ruskie, S | 1 |
| Arai, H; Degawa, M; Hashimoto, Y; Matsuda, K | 1 |
| Drela, N; Izdebska-Szymona, K; Kopeć-Szlezak, J; Kozłowska, E; Pańczyk, S | 1 |
| Glatt, HR; Hayashi, M; Matsuoka, A; Ozaki, M; Sakamoto, H; Sofuni, T; Takeshita, K | 1 |
| Couch, LH; Howard, PC; Mukhtar, H; Rorke, EA; Sizemore, N | 1 |
| Brunborg, G; Haug, K; Holme, JA; Johnsen, NM; Scholz, T | 1 |
| Fung, J; Iba, MM; Thomas, PE | 1 |
| Cueto, R; Pryor, WA; Salgo, MG; Winston, GW | 1 |
| Biagi, GL; Cantelli-Forti, G; Mazzullo, M; Paolini, M; Perocco, P | 1 |
| Furukawa, A; Huang, DY; Ichikawa, Y; Jiang, H; Ohnishi, T | 1 |
| Fukuhara, M; Kato, K; Kimura, M; Sun, B; Yamazaki, S | 1 |
| Brauze, D; Malejka-Giganti, D | 1 |
| Borman, SM; Christian, PJ; Hoyer, PB; Sipes, IG | 1 |
| Brault, K; Lapierre, I; Mathieu, MC; Raymond, M | 1 |
| Behrens, A; Bols, NC; Schirmer, K; Segner, H | 1 |
| Auyeung, DJ; Kessler, FK; Ritter, JK | 1 |
| Ball, JK | 1 |
| Fujii-Kuriyama, Y; Fujimoto, H; Hikida, M; Mimura, J; Ogi, T; Ohmori, H | 1 |
| Chung, KH; Kim, KR; Oh, SM; Ro, KS | 1 |
| Barra, Y; De Meo, M; Fallone, F; Fina, F; Guigal, N; Lacarelle, B; Martin, PM; N'Guyen, QB; Seree, E; Villard, PH | 1 |
| Fernandez-Salguero, P; Gonzalez, FJ; Jiang, W; Kondraganti, SR; Moorthy, B; Ramos, KS | 1 |
| Bonfanti, P; Camatini, M; Colombo, A; Orsi, F | 1 |
| AR FFMANN, E; CHRISTENSEN, BC | 1 |
| ALFRED, LJ; BERWALD, Y; GLOBERSON, A; PREHN, RT | 1 |
| Hayashi, H; Hirose, K; Katagiri, D; Miyazawa, K; Nakajima, H; Onozaki, K; Takii, T; Tamaki, A | 1 |
| Choi, S; Nishikawa, M; Sakai, Y; Sakoda, A | 1 |
| Ahr, HJ; Duan, JD; Enzmann, HH; Jeffrey, AM; Perrone, CE; Schmidt, U; Williams, GM | 1 |
| Donovan, PJ; Nardone, R; Smith, GT | 1 |
| Hiramatsu, N; Kasai, A; Kitamura, M; Maeda, S; Meng, Y; Takeda, M; Yao, J | 1 |
| El-Kadi, AO; Elbekai, RH; Gharavi, N; Korashy, HM; Wills, K | 1 |
| Hiramatsu, N; Kasai, A; Kitamura, M; Maeda, S; Meng, Y; Yao, J | 1 |
| Dhiman, M; Kale, RK; Mendiz, E; Rao, AR | 1 |
| Hioki, K; Hirose, M; Ishii, Y; Kanki, K; Kodama, Y; Kuroiwa, Y; Kurokawa, Y; Nishikawa, A; Nomura, T; Umemura, T | 1 |
| Chan, PK; Liao, JW; Lu, SY; Tsai, Y; Ueng, TH; Wei, CF | 1 |
| Abdelrahim, M; Ariazi, E; Jordan, VC; Khan, S; Liu, S; Safe, S | 1 |
| Beaton, D; Chen, S; Nguyen, N; Operaña, TN; Tukey, RH | 1 |
| James, MO; Nyagode, BA; Stuchal, LD | 1 |
| Bolotina, NA; Kobliakov, VA; Sharovskaia, IuIu | 1 |
| Bock, KW; Bock-Hennig, BS | 1 |
| Aboutabl, ME; El-Kadi, AO; Zordoky, BN | 1 |
| Bandiera, SM; Chang, TK; Deb, S; Kawai, M | 1 |
| Celius, T; Henderson, MC; Krueger, SK; Matthews, J; Okey, AB; Pansoy, A; Williams, DE | 1 |
| Abel, J; Bothe, H; Fritsche, E; Gassmann, K; Haarmann-Stemmann, T; Merk, HF; Quasthoff, KN; Rockel, TD; Schreiber, T | 1 |
| Borlak, J; Corvi, R; Linge, J; Maaser, K; Rohrbeck, A; Salinas, G; Salovaara, S | 1 |
| Audebert, M; Cravedi, JP; Hillenweck, A; Jacques, C; Jamin, EL; Riu, A; Zalko, D | 1 |
| Kobliakov, VA; Volkov, MS | 1 |
| Anwar-Mohamed, A; Eckers, A; El-Kadi, AO; Esser, C; Hamann, I; Klotz, LO; Sauerbier, E; Schroeder, P | 1 |
| Hirakawa, T; Nemoto, N; Takayama, S | 1 |
| Conney, AH; Reidenberg, MM | 1 |
| Abel, J; Förster, I; Fritsche, E; Götz, C; Haarmann-Stemmann, T; Huebenthal, U; Kohne, Z; Krutmann, J; Merk, HF; Tigges, J; Weighardt, H; Wolff, S | 1 |
| Brauze, D; Rawłuszko, AA | 1 |
9 review(s) available for 3-methylcholanthrene and benzo(a)pyrene
| Article | Year |
|---|---|
[Effect of monoclonal antibody against methylcholanthrene-induced cytochrome P-450 forms on benzo(a)pyrene metabolism in hepatic microsomes of C57BL/10 mice].
Topics: Animals; Antibodies, Monoclonal; Benzo(a)pyrene; Culture Media; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver | 1990 |
International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC Working Paper 7/1/1. Mutational events in the etiology of arteriosclerotic plaques.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arsenic; Arteriosclerosis; Benzo(a)pyrene; DNA Damage; Herpesviridae; Humans; Methylcholanthrene; Mice; Muscle, Smooth, Vascular; Mutation; Transformation, Genetic | 1990 |
The 4S binding protein acts as a trans-regulator of the polycyclic hydrocarbon-inducible cytochrome P450.
Topics: Animals; Benzo(a)pyrene; Carrier Proteins; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; Methylcholanthrene; Phenobarbital; Rats | 1988 |
Induction of microsomal cytochrome P-450 enzymes: the first Bernard B. Brodie lecture at Pennsylvania State University.
Topics: Amino Acid Sequence; Amino Acids; Animals; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Dietary Proteins; Drug Interactions; Enzyme Induction; Ethionine; Female; Humans; Inactivation, Metabolic; Isoenzymes; Methionine; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Pregnancy; Smoking | 1986 |
Mammalian cell mutation and polycyclic hydrocarbon carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Chemical Phenomena; Chemistry; DNA; Epoxy Compounds; Gene Expression Regulation; Humans; Hypoxanthine Phosphoribosyltransferase; Methylcholanthrene; Mutation; Oncogenes; Polycyclic Compounds; Structure-Activity Relationship | 1985 |
Laboratory decontamination and destruction of carcinogens in laboratory wastes: some polycyclic aromatic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biodegradation, Environmental; Carcinogens; Chemical Phenomena; Chemistry; Chemistry, Physical; Decontamination; Hydrogen-Ion Concentration; Laboratories; Methylcholanthrene; Oxidation-Reduction; Polycyclic Compounds; Potassium Permanganate; Safety; Solutions; Sulfuric Acids; Waste Products; World Health Organization | 1983 |
Microbial metabolism of polycyclic aromatic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthracenes; Bacteria; Benz(a)Anthracenes; Benzo(a)pyrene; Biodegradation, Environmental; Biotransformation; Carcinogens, Environmental; Eukaryota; Fungi; Humans; Mammals; Methylcholanthrene; Mice; Naphthalenes; Phenanthrenes; Polycyclic Compounds; Pyrenes; Structure-Activity Relationship | 1984 |
32P-postlabelling in studies of polycyclic aromatic hydrocarbon activation.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Biotransformation; DNA; DNA Damage; Environmental Pollutants; Male; Methylcholanthrene; Mice; Phosphorus Radioisotopes; Polycyclic Compounds; Rats | 1993 |
UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors.
Topics: Animals; Antioxidants; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Bilirubin; Caco-2 Cells; Carcinogens; Cells, Cultured; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Humans; In Situ Hybridization; Inactivation, Metabolic; Liver; Male; Methylcholanthrene; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Xenobiotics | 2010 |
248 other study(ies) available for 3-methylcholanthrene and benzo(a)pyrene
| Article | Year |
|---|---|
Voronoi binding site model of a polycyclic aromatic hydrocarbon binding protein.
Topics: Animals; Benzo(a)pyrene; Binding Sites; Binding, Competitive; Carrier Proteins; Liver; Male; Mice; Mice, Inbred C57BL; Models, Chemical; Molecular Structure; Polycyclic Compounds; Structure-Activity Relationship | 1990 |
P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Carcinogens; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Gene Expression; Liver; Methylcholanthrene; Molecular Sequence Data; Oxidoreductases; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
[The effect of lysolecithin on rat liver microsome monooxygenase activity after induction by xenobiotics of the methylcholanthrene type].
Topics: Animals; Anisoles; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Coumarins; Enzyme Induction; Hydroxylation; Intracellular Membranes; Lysophosphatidylcholines; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Polychlorinated Biphenyls; Rats; Substrate Specificity | 1992 |
Mechanism of antimutagenicity of wheat sprout extracts.
Topics: Animals; Antimutagenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Chlorophyll; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Oxidoreductases; Phenobarbital; Plant Extracts; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Triticum | 1992 |
Mono- and diglucuronide formation from chrysene and benzo(a)pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).
Topics: Animals; Benzo(a)pyrene; Cells, Cultured; Chrysenes; Cricetinae; Enzyme Induction; Glucuronates; Glucuronosyltransferase; In Vitro Techniques; Liver; Methylcholanthrene; Phenobarbital; Phenols; Rats | 1992 |
Bronchial and pulmonary carcinogenesis at focal sites in dogs and hamsters.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Bronchoscopy; Carcinogens; Cricetinae; Disease Models, Animal; Dogs; Drug Implants; Injections; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mucous Membrane | 1992 |
Turmeric (Curcuma longa)-induced reduction in urinary mutagens.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Body Weight; Curcumin; Dose-Response Relationship, Drug; Histiocytoma, Benign Fibrous; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains | 1991 |
Comparative metabolism of 7H-dibenzo[c,g]carbazole and dibenz[a,j]acridine by mouse and rat liver microsomes.
Topics: Acridines; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carbazoles; Carbon Radioisotopes; Carcinogens; Chromatography, High Pressure Liquid; Female; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Microsomes, Liver; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains | 1992 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines | 1991 |
Transforming activity of ethylene dibromide in BALB/c 3T3 cells.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Ethylene Dibromide; Methylcholanthrene; Mice | 1991 |
Ah locus-associated differences in induction of sister-chromatid exchanges and in DNA adducts by benzo[a]pyrene in mice.
Topics: Animals; Benzo(a)pyrene; Bone Marrow; Dose-Response Relationship, Drug; Ethylnitrosourea; Lymphocytes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mutagenicity Tests; Receptors, Aryl Hydrocarbon; Receptors, Drug; Sister Chromatid Exchange; Spleen | 1991 |
Presence of the 4 S polycyclic hydrocarbon-binding protein in H4-II-E cells.
Topics: Animals; Benzo(a)pyrene; Carrier Proteins; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Glycine N-Methyltransferase; Liver Neoplasms, Experimental; Methylcholanthrene; Methyltransferases; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Receptors, Aryl Hydrocarbon; Receptors, Drug; RNA, Messenger; Tumor Cells, Cultured | 1991 |
[Induction of cytochrome P-450 by triterpensaponins in Vietnamese ginseng].
Topics: Aminopyrine; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Isoenzymes; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Saponins; Triterpenes | 1991 |
Effects of ozonation on mutagenic activity of polycyclic aromatic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benzo(a)pyrene; Biotransformation; Chromatography, High Pressure Liquid; Chrysenes; Fluorometry; Methylcholanthrene; Mutagenicity Tests; Ozone; Polycyclic Compounds; Salmonella typhimurium; Spectrophotometry, Ultraviolet | 1991 |
Altered benzo[a]pyrene metabolism in C3H/10T1/2 cells transformed by aflatoxin B1 or 3-methylcholanthrene.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; DNA; DNA Adducts; gamma-Glutamyltransferase; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Methylcholanthrene | 1990 |
Kinetics of induction of cytosolic benzaldehyde: NADP and propionaldehyde: NAD aldehyde dehydrogenase activities in rat livers from male Wistar rats.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytosol; Enzyme Induction; Glutathione Transferase; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains | 1991 |
High-performance liquid chromatographic method for the determination of polycyclic hydrocarbon metabolite distributions.
Topics: Acridines; Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Particle Size; Polycyclic Compounds; Rats | 1990 |
Diethylstilbestrol potentiates and testosterone antagonizes the action of 3-methylcholanthrene on benzo(a)pyrene metabolism in Hep G2 cells.
Topics: Benzo(a)pyrene; Benzopyrene Hydroxylase; Cell Line, Transformed; Chromatography, High Pressure Liquid; Diethylstilbestrol; Drug Interactions; Enzyme Induction; Epoxide Hydrolases; Humans; Liver; Methylcholanthrene; Testosterone | 1990 |
The effect of complete carcinogens on intercellular transfer of lucifer yellow in fibroblast culture.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Carcinogens; Cell Line, Transformed; Cell Membrane Permeability; Cell Transformation, Viral; Cricetinae; Ethyl Methanesulfonate; Fibroblasts; Intercellular Junctions; Isoquinolines; Methylcholanthrene | 1990 |
Acute inhibition of DNA synthesis in hamster buccal pouch epithelium exposed to indirect acting carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Carcinogens; Cell Division; Cricetinae; Dimethylnitrosamine; DNA; Male; Mesocricetus; Methylcholanthrene; Mouth Mucosa; Necrosis; Time Factors | 1990 |
Development of an optimal S9 activation mixture for the L5178Y TK+/- mouse lymphoma mutation assay.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cyclophosphamide; Dimethylnitrosamine; Lymphoma; Methylcholanthrene; Mice; Microsomes, Liver; Mutagenicity Tests; NADP; Thymidine Kinase; Time Factors; Tumor Cells, Cultured | 1990 |
Dexamethasone-mediated potentiation of P450IA1 induction in H4IIEC3/T hepatoma cells is dependent on a time-consuming process and associated with induction of the Ah receptor.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Cytosol; Dexamethasone; Enzyme Induction; Hydrocarbons; Hydroxylation; Kinetics; Liver Neoplasms; Methylcholanthrene; Oxazines; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Receptors, Drug; Tritium; Tumor Cells, Cultured | 1990 |
Effects of 1-ethynylpyrene and related inhibitors of P450 isozymes upon benzo[a]pyrene metabolism by liver microsomes.
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme Inhibitors; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Naphthalenes; Perylene; Pyrenes; Rats; Rats, Inbred Strains | 1990 |
Prochloraz as potent inhibitor of benzo[a]pyrene metabolism and mutagenic activity in rat liver fractions.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cytochrome P-450 Enzyme System; Enzyme Induction; Fungicides, Industrial; Imidazoles; Liver; Male; Methylcholanthrene; Miconazole; Mutagenicity Tests; Rats; Rats, Inbred Strains | 1990 |
Use of rat primary lung cells for studying genotoxicity with the sister-chromatid exchange and micronucleus assays.
Topics: Animals; Benzo(a)pyrene; Cell Division; Cells, Cultured; Cytochalasin B; Dose-Response Relationship, Drug; Lung; Male; Methylcholanthrene; Micronucleus Tests; Mitomycins; Rats; Rats, Inbred Strains; Sister Chromatid Exchange; Triethylenemelamine | 1990 |
Multistage neoplastic transformation of Syrian hamster embryo cells cultured at pH 6.70.
Topics: Animals; Benzo(a)pyrene; Cell Count; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Embryo, Mammalian; Hydrogen-Ion Concentration; Karyotyping; Mesocricetus; Methylcholanthrene; Phenotype | 1990 |
Induction of cytochrome P450IA1 in rat hepatoma cell by polycyclic hydrocarbons and a dioxin.
Topics: Animals; Benzo(a)pyrene; Benzofurans; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver Neoplasms, Experimental; Methylcholanthrene; Polychlorinated Dibenzodioxins; Rats; Tumor Cells, Cultured | 1990 |
Influence of chlordecone and mirex exposure on benzo[a]pyrene metabolism of rat-liver microsomes.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Biotransformation; Chlordecone; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Insecticides; Liver; Methylcholanthrene; Microsomes, Liver; Mirex; Pesticide Residues; Phenobarbital; Rats; Subcellular Fractions | 1987 |
Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Chlordecone; Cytochrome P-450 Enzyme System; Gerbillinae; Insecticides; Male; Methylcholanthrene; Microsomes, Liver; Mirex; Phenobarbital | 1987 |
Influence of protein and RNA synthesis inhibitors on methylcholanthrene-mediated induction of aryl hydrocarbon hydroxylase activity in intestinal mucosa.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cycloheximide; Dactinomycin; Deoxyadenosines; Enzyme Induction; In Vitro Techniques; Intestinal Mucosa; Leucine; Male; Methylcholanthrene; Microsomes; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA | 1988 |
Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including man.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Biotransformation; Cricetinae; Humans; Male; Mesocricetus; Methylcholanthrene; Mice; Mice, Inbred Strains; Mitochondria, Liver; Mutagenicity Tests; Polycyclic Compounds; Rats; Rats, Inbred Strains; Salmonella typhimurium; Swine | 1989 |
Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Diabetes Mellitus, Experimental; Imidazoles; Insulin; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutagens; Niacinamide; Nitrosamines; Rats; Rats, Inbred Strains; Salmonella typhimurium | 1989 |
Binding of 7H-dibenzo[c,g]carbazole to polynucleotides and DNA in vitro.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carbazoles; Carcinogens; Cricetinae; DNA; Environmental Pollutants; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Molecular Structure; Polynucleotides; Rats; Rats, Inbred Strains; RNA, Fungal | 1989 |
Inhibition of morphological transformation of C3H10T1/2CL8 mouse embryo cells by multiple carcinogen treatments.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred C3H | 1989 |
Immunodetection, immunoinhibition, immunoquantitation and biochemical analyses of cytochrome P-450IA1 in tissues of the ratoffceptus during the progression of organogenesis.
Topics: 2-Acetylaminofluorene; Amnion; Animals; Benzo(a)pyrene; Benzoflavones; Chorion; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Embryo, Mammalian; Enzyme Induction; Female; Gestational Age; Immunologic Techniques; Isoenzymes; Methylcholanthrene; Metyrapone; Morphogenesis; Oxazines; Placenta; Pregnancy; Rats; Rats, Inbred Strains; Yolk Sac | 1989 |
[Ultrastructural and histogenetic studies on experimental pulmonary carcinoma].
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Animals; Benzo(a)pyrene; Carcinoma, Squamous Cell; Cricetinae; Hyperplasia; Lung Neoplasms; Male; Mesocricetus; Metaplasia; Methylcholanthrene; Rats; Rats, Inbred Strains | 1987 |
Carcinogenic-mutagenic chemicals induced chromosomal aberrations in the kidney cells of three cyprinids.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aroclors; Benzidines; Benzo(a)pyrene; Carcinogens; Chlorodiphenyl (54% Chlorine); Chromosome Aberrations; Cyprinidae; Kidney; Methylcholanthrene; Mutagens; Species Specificity | 1985 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzyme Induction; Female; Isoenzymes; Karyotyping; Liver Neoplasms, Experimental; Methylcholanthrene; NADP; Neoplasm Transplantation; Organoids; Phenobarbital; Phenotype; Rats; Tyrosine Transaminase | 1986 |
[Ultrastructural study on the tracheal epithelium of hamsters induced by chemical carcinogen].
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Cricetinae; Culture Techniques; Epithelium; Hyperplasia; Mesocricetus; Metaplasia; Methylcholanthrene; Trachea | 1987 |
Formation of benzo(alpha)pyrene metabolites and DNA adducts catalyzed by a rat liver mitochondrial monooxygenase system.
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA; DNA, Mitochondrial; Glucose-6-Phosphatase; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Inbred Strains | 1985 |
Regulation of rat and bovine adrenal metabolism of polycyclic aromatic hydrocarbons by adrenocorticotropin and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Benzo(a)pyrene; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Dioxins; Male; Methylcholanthrene; Microsomes; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1986 |
Pyridine prevents the clastogenicity of benzene but not of benzo[a]pyrene or cyclophosphamide.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzene; Benzo(a)pyrene; Biotransformation; Cell Nucleus; Cyclophosphamide; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Drug Interactions; Drug Resistance; Isoenzymes; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred ICR; Mutagenicity Tests; Pyridines; Receptors, Aryl Hydrocarbon; Receptors, Drug; Xylenes | 1987 |
Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene.
Topics: Benzo(a)pyrene; Centrifugation, Density Gradient; Charcoal; Cytosol; Dioxins; Female; Humans; In Vitro Techniques; Methylcholanthrene; Molybdenum; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Radioligand Assay; Receptors, Aryl Hydrocarbon; Receptors, Drug; Tissue Preservation | 1987 |
[Biosynthesis in the rat liver of a common form of monooxygenase induced by xenobiotics of a methylcholanthrene series].
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Hydroxylation; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains | 1986 |
Pulmonary microsomal cytochrome P-450 from 3-methylcholanthrene-treated hamsters: purification, characterization, and metabolism of benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Immunodiffusion; Isoenzymes; Lung; Male; Mesocricetus; Methylcholanthrene; Microsomes; Molecular Weight | 1986 |
Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; DNA; Enzyme Induction; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucuronic Acid | 1987 |
Evaluation of Pluronic Polyol F127 as a vehicle for petroleum hydrocarbons in the Salmonella/microsomal assay.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alcohols; Benzo(a)pyrene; Cell Survival; Hydrocarbons; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Mutation; Petroleum; Poloxalene; Polyethylene Glycols; Salmonella typhimurium | 1987 |
A test using cultured cells with induced mixed-function oxygenase in the unscheduled DNA synthesis assay for detecting promutagens/procarcinogens.
Topics: Aflatoxin B1; Aflatoxins; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Carcinogens; Cells, Cultured; DNA Damage; DNA Repair; Enzyme Induction; Humans; Methylcholanthrene; Mixed Function Oxygenases; Mutagenicity Tests; Mutagens | 1987 |
Further investigations into the effect of non-benzo ring bay-region methyl substituents on tumor-initiating activity of polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Female; Methylcholanthrene; Mice; Papilloma; Skin Neoplasms; Structure-Activity Relationship | 1987 |
Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Anthraquinones; Benzo(a)pyrene; DNA; Female; Flavonoids; Hydrolyzable Tannins; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred BALB C; Quercetin; Skin Neoplasms; Tannins | 1988 |
Intestinal absorption of carcinogenic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Bile Acids and Salts; Carcinogens; Hydrocarbons; Intestinal Absorption; Methylcholanthrene; Solubility | 1988 |
Benzo[a]pyrene metabolism and induction of enzyme-altered foci in regenerating rat liver.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Glutathione; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Rats; Rats, Inbred Strains; Regeneration | 1988 |
Influence of long term treatment with 3-methylcholanthrene or carbaryl on mixed-function oxidase activity in 3T3 fibroblasts: studies by microspectrofluorimetry on single cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Carbaryl; Cells, Cultured; Fibroblasts; Kinetics; Methylcholanthrene; Mice; Mixed Function Oxygenases; Spectrometry, Fluorescence; Time Factors | 1988 |
Effects of various inducers on the activities of cytochrome P-450-mixed function oxidases and aflatoxin B1 activation in microsomes of hamster livers.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzo(a)pyrene; Benzoflavones; Biotransformation; Cricetinae; DNA; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases | 1988 |
Modulating effects of beta-naphthoflavone on the induction of SCEs by model compounds with emphasis on benzo[a]pyrene.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Biotransformation; Cells, Cultured; Chickens; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Liver; Methylcholanthrene; Microsomes, Liver; Sister Chromatid Exchange | 1988 |
Inducible high-affinity binding site for benzo(a)pyrene in cytosol from rat liver.
Topics: Animals; Benzo(a)pyrene; Binding Sites; Binding, Competitive; Centrifugation, Density Gradient; Cytosol; Hypertrophy; Liver; Male; Methylcholanthrene; Peptide Hydrolases; Rats; Rats, Inbred Strains; Ribonucleases; Stimulation, Chemical | 1987 |
Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of fluorinated derivatives of benzo[a]pyrene and 3-methylcholanthrene.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Female; Hydrocarbons, Fluorinated; Mammary Neoplasms, Experimental; Methylcholanthrene; Mice; Rats; Rats, Inbred Strains; Skin Neoplasms; Structure-Activity Relationship | 1988 |
Qualitative and quantitative differences in the induction and inhibition of hepatic benzo[a]pyrene metabolism in the rat and hamster.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Microsomes, Liver; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Safrole; Species Specificity | 1988 |
A single neonatal treatment with methylcholanthrene or benzo(a)pyrene alters microsomal enzyme activity for life.
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Female; Male; Methylcholanthrene; Microsomes, Liver; Rats; Time Factors | 1987 |
Absolute configurations of K-region epoxide enantiomers of 3-methylcholanthrene, benz[a]anthracene, and benzo[a]pyrene.
Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Epoxy Compounds; Ethers, Cyclic; Methylcholanthrene; Molecular Conformation; Stereoisomerism | 1987 |
Clonal origin of tumors induced by ultraviolet radiation.
Topics: Animals; Benzo(a)pyrene; Female; Methylcholanthrene; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Radiation-Induced; Phosphoglycerate Kinase; Ultraviolet Rays | 1986 |
H-2 modulation of aryl hydrocarbon hydroxylase induction and the mutagenicity of benzo(a)pyrene after 3-methylcholanthrene treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Kinetics; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mutagenicity Tests; Mutation; Rats; Salmonella typhimurium | 1986 |
Selenium inhibition of benzo[a]pyrene, 3-methylcholanthrene, and 3-methylcholanthrylene mutagenicity in Salmonella typhimurium strains TA98 and TA100.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biotransformation; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Rats; Rats, Inbred Strains; Salmonella typhimurium; Selenic Acid; Selenium; Selenium Compounds; Sulfites | 1987 |
Benzo[a]pyrene metabolism by purified cytochrome P-450 from 3-methylcholanthrene-treated rats.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; In Vitro Techniques; Lung; Methylcholanthrene; Microsomes; Microsomes, Liver; Rats | 1987 |
[Kinetic characteristics of 3,4-benzpyrene hydroxylation in the liver microsomes of mice].
Topics: Animals; Benzo(a)pyrene; Hydroxylation; Kinetics; Membrane Lipids; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phospholipids; Protein Binding; Spectrometry, Fluorescence | 1987 |
[The role of vitamin K3 in the hydroxylation of benz(a)pyrene in rat liver mitochondria after induction with 3-methylcholanthrene and phenobarbital].
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Hydroxylation; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred F344; Rats, Inbred Strains; Vitamin K | 1987 |
Enzyme induction in rat lung and liver by condensates and fractions from main-stream and side-stream cigarette smoke.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP2E1; Enzyme Induction; Lung; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Mutagenicity Tests; Nicotiana; Oxidoreductases, N-Demethylating; Phenobarbital; Plants, Toxic; Rats; Rats, Inbred Strains; Smoke; Spectrometry, Fluorescence; Spectrophotometry | 1987 |
Mutagenicity of the mononitrobenzo[a]pyrenes in Chinese hamster ovary cells mediated by rat hepatocytes or liver S9.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzopyrenes; Chlorodiphenyl (54% Chlorine); Cricetinae; Cricetulus; Dimethyl Sulfoxide; Female; Liver; Methylcholanthrene; Mutagenicity Tests; Mutagens; Ovary; Rats | 1986 |
Dependence of benzo[a]pyrene metabolic profile on the concentration of cumene hydroperoxide with uninduced and induced rat liver microsomes.
Topics: Animals; Aroclors; Benzene Derivatives; Benzo(a)pyrene; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1986 |
[Cytochrome P-448 induction in liver microsomes of mice of inbred strains after administration of xenobiotics of MC-type].
Topics: Animals; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Microsomes, Liver; Rabbits; Species Specificity; Substrate Specificity | 1986 |
Regioselective inhibition of benzo(a)pyrene metabolism by corticosterone in comparison with metyrapone and alpha-naphthoflavone.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Chromatography, High Pressure Liquid; Corticosterone; Cytochrome P-450 Enzyme System; Drug Interactions; Flavonoids; Injections, Intraperitoneal; Male; Methylcholanthrene; Microsomes, Liver; Pentobarbital; Pyridines; Rats; Rats, Inbred Strains | 1986 |
Effect of ellagic acid and 3-O-decylellagic acid on the formation of benzo[a]pyrene-derived DNA adducts in vivo and on the tumorigenicity of 3-methylcholanthrene in mice.
Topics: Animals; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrans; DNA; Dose-Response Relationship, Drug; Ellagic Acid; Female; Lung; Methylcholanthrene; Mice; Mice, Inbred BALB C; Skin; Skin Neoplasms; Time Factors; Tritium | 1986 |
Effects of inducers on the regio- and stereoselective metabolism of benzo[a]pyrene by mouse tissue microsomes.
Topics: Animals; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Dihydroxydihydrobenzopyrenes; Drug Interactions; Injections, Intraperitoneal; Liver; Lung; Male; Methylcholanthrene; Mice; Microsomes; Phenobarbital; Skin | 1986 |
Cytochrome P-450-catalyzed stereoselective epoxidation at the K region of benz[a]anthracene and benzo[a]pyrene.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Epoxy Compounds; Ethers, Cyclic; Isoenzymes; Male; Mathematics; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
[Experimental lung cancer induced by chemical carcinogens and immunity].
Topics: 4-Nitroquinoline-1-oxide; Adjuvants, Immunologic; Animals; Benzo(a)pyrene; Female; Immunotherapy; Lung Neoplasms; Male; Methylcholanthrene; Mice; Rabbits; Rats | 1985 |
Cross-reactive cellular and humoral immunity to carcinogen-induced chicken fibrosarcomas. I. Protective cross-immunity between transplantable tumor lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antibodies, Neoplasm; Antibody Formation; Antigens, Neoplasm; Benzo(a)pyrene; Chickens; Cross Reactions; Fibrosarcoma; Graft Rejection; Hypersensitivity, Delayed; Immunity, Cellular; Methylcholanthrene; Neoplasm Transplantation; Sarcoma, Experimental | 1985 |
Carcinogen-binding proteins in the rat ventral prostate: specific and nonspecific high-affinity binding sites for benzo(a)pyrene, 3-methylcholanthrene, and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Animals; Benzo(a)pyrene; Binding, Competitive; Carrier Proteins; Cytosol; Dioxins; Male; Methylcholanthrene; Polychlorinated Dibenzodioxins; Prostate; Rats; Receptors, Steroid | 1986 |
Effect of asbestos fibers on aryl hydrocarbon hydroxylase and aminopyrine N-demethylase activities of rat liver microsomes.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Asbestos; Benzo(a)pyrene; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; p-Aminohippuric Acid; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Brain microsomal enzyme mediated covalent binding of benzo[a]pyrene to DNA.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Brain; Cattle; DNA; In Vitro Techniques; Male; Methylcholanthrene; Microsomes; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Thymus Gland | 1985 |
Induction of colon cancer in inbred Syrian hamsters by intrarectal administration of benzo[alpha]pyrene, 3-methylcholanthrene and N-methyl-N-nitrosourea.
Topics: Animals; Benzo(a)pyrene; Colonic Neoplasms; Cricetinae; Male; Mesocricetus; Methylcholanthrene; Methylnitrosourea; Rectum | 1985 |
[Participation of cytochrome P-448 in 3,4-benzopyrene metabolism during induction by different xenobiotics in inbred mouse strains].
Topics: Animals; Antibodies; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochromes; Enzyme Induction; Immunization; Male; Methylcholanthrene; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Microsomes, Liver; Polychlorinated Dibenzodioxins | 1985 |
Polycyclic aromatic hydrocarbon binding macromolecules. Identification, characterization and temperature activation of a 4.5 S binding nucleoprotein.
Topics: Animals; Benzo(a)pyrene; Carrier Proteins; Chromatography, Gel; Cytosol; Female; Methylcholanthrene; Nucleoproteins; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Rats; Rats, Inbred Strains; Temperature; Tritium | 1985 |
[Induction of cytochrome P-450 forms in liver microsomes of rats in the early neonatal period after administration of phenobarbital and 3-methylcholanthrene].
Topics: Animals; Animals, Newborn; Benzo(a)pyrene; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
[Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Catalysis; Cell Nucleus; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Endoplasmic Reticulum; Enzyme Induction; Intracellular Membranes; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Substrate Specificity | 1985 |
Chemical carcinogen-mediated decreases in DNA 5-methylcytosine content of BALB/3T3 cells.
Topics: 5-Methylcytosine; Aflatoxin B1; Aflatoxins; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Fibroblasts; In Vitro Techniques; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phenanthrenes | 1984 |
Binding of metabolically activated aromatic hydrocarbons to nonhistone proteins of rat liver nuclei.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cell Nucleus; Chromosomal Proteins, Non-Histone; Histones; In Vitro Techniques; Liver; Male; Methylcholanthrene; Proteins; Rats; RNA Polymerase II | 1983 |
Determination of cytochrome P-448 activity in biological tissues.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Ellipticines; In Vitro Techniques; Male; Methods; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxazines; Rats; Rats, Inbred Strains; Substrate Specificity | 1984 |
Clotrimazole, an inhibitor of epidermal benzo(a)pyrene metabolism and DNA binding and carcinogenicity of the hydrocarbon.
Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Clotrimazole; DNA; Imidazoles; Kinetics; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes; Rats; Rats, Inbred Strains; Skin; Skin Neoplasms | 1984 |
[Immunological reactivity of mice with transplanted lung tumors obtained via organ culture].
Topics: Adenocarcinoma; Animals; Antibody-Producing Cells; Benzo(a)pyrene; Benzopyrenes; Lung; Lung Neoplasms; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred BALB C; Neoplasm Transplantation; Organ Culture Techniques; Sarcoma, Experimental; Spleen | 1984 |
The effectiveness of chemical carcinogens to induce atherosclerosis in the white Carneau pigeon.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aorta, Abdominal; Arteriosclerosis; Benzo(a)pyrene; Benzopyrenes; Blood Pressure; Carcinogens; Chlorophenols; Cholesterol; Columbidae; Lipoproteins, HDL; Lipoproteins, LDL; Male; Methylcholanthrene | 1984 |
Differential induction of various carboxylesterases by certain polycyclic aromatic hydrocarbons in the rat.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carboxylic Ester Hydrolases; Chrysenes; Enzyme Induction; Intestinal Mucosa; Kidney; Liver; Male; Methylcholanthrene; Nitrophenols; Phenanthrenes; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1984 |
Dose-response studies on neoplastic transformation of BALB/3T3 clone A31-1-1 cells by aflatoxin B1, benzidine, benzo[a]pyrene, 3-methylcholanthrene, and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Aflatoxin B1; Aflatoxins; Animals; Benzidines; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C | 1983 |
3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes; NADP; NADPH-Ferrihemoprotein Reductase; Nephropidae; Pancreas; Pharmaceutical Preparations; Species Specificity; Water Pollutants, Chemical | 1984 |
Position-specific induction of benzo(a)pyrene metabolism by 3-methylcholanthrene and phenobarbital in mullet (Mugil cephalus), a marine fish.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Chemical Phenomena; Chemistry; Enzyme Induction; Epoxide Hydrolases; Fishes; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Trichloroepoxypropane | 1984 |
Characterization of benzo[a]pyrene metabolites formed by 3-methylcholanthrene-induced goldfish, black bullhead and brown bullhead.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Chromatography, High Pressure Liquid; Fishes; Goldfish; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Polycyclic Compounds; Rats; Rats, Inbred Strains; Trichloroepoxypropane | 1984 |
Conversion of procarcinogens to mutagens by the S-9 fraction from the liver of rainbow trout (Salmo gairdneri): inducibility with PCB, 3-methylcholanthrene and phenobarbital and inhibition by metyrapone and alpha-naphthoflavone.
Topics: 2-Acetylaminofluorene; Animals; Anthracenes; Benzo(a)pyrene; Benzoflavones; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Liver; Methylcholanthrene; Metyrapone; Mutagenicity Tests; Mutagens; Phenobarbital; Polychlorinated Biphenyls; Salmonidae; Subcellular Fractions; Temperature; Trout | 1984 |
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Binding Sites; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Epitopes; Humans; Hybridomas; Immunization; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Rabbits; Rats | 1982 |
The influence of polycyclic hydrocarbons on the activity of NAD(P)H-dehydrogenating enzymes in rat thymus. A biochemical and histochemical study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adrenalectomy; Animals; Benzo(a)pyrene; Benzopyrenes; Dicumarol; Methylcholanthrene; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Polycyclic Compounds; Quinone Reductases; Rats; Thymus Gland | 1983 |
Polycyclic aromatic hydrocarbon toxicity and induction of metabolism in cultivated esophageal and epidermal keratinocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Epidermal Cells; Epidermis; Esophagus; Keratins; Methylcholanthrene; Mice; Polycyclic Compounds | 1983 |
Oxidation and subsequent glucuronidation of 3,4-benzopyrene in everted intestinal sacs in control and 3-methylcholanthrene-pretreated rats.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Enzyme Induction; Glucuronates; Intestinal Mucosa; Intestines; Male; Methylcholanthrene; Oxidation-Reduction; Rats | 1980 |
Effect of diet on fecal excretion and gastrointestinal tract distribution of unmetabolized benzo(a)pyrene and 3- methylcholanthrene when these compounds are administered orally to hamsters.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cricetinae; Digestive System; Feces; Food, Formulated; Male; Mesocricetus; Methylcholanthrene; Triticum | 1981 |
Metabolism of 3-methylcholanthrene in rat pancreas.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; In Vitro Techniques; Injections, Intraperitoneal; Liver; Male; Methylcholanthrene; Pancreas; Phenobarbital; Rats; Time Factors | 1981 |
Induction of aldehyde dehydrogenase by polycyclic aromatic hydrocarbons in rats.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Chrysenes; Cytosol; Enzyme Induction; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenanthrenes; Polycyclic Compounds; Rats | 1981 |
Relationship between benzo(a)pyrene-induced DNA base modification and frequency of reverse mutations in mutant strains of Salmonella typhimurium.
Topics: Animals; Base Composition; Benzo(a)pyrene; Benzopyrenes; Deoxyribonucleosides; DNA, Bacterial; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Mutation; Rats; Salmonella typhimurium | 1981 |
Effects of phenobarbital, 3-methylcholanthrene and beta-naphthoflavone pretreatment on mouse liver microsomal enzymes and on metabolite patterns of benzo[a]pyrene.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dihydroxydihydrobenzopyrenes; Flavonoids; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Proteins | 1981 |
Effects of butylated hydroxyanisole on the aryl hydrocarbon hydroxylase of rats and mice.
Topics: Animals; Anisoles; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cell Nucleus; Female; Lung; Male; Methylcholanthrene; Mice; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Skin | 1981 |
Effect of certain neurotoxins and mixed function oxidase modifiers on glutathione-S-transferase activity of rat brain.
Topics: Acrylamide; Acrylamides; Animals; Benzo(a)pyrene; Benzopyrenes; Brain; Dinitrochlorobenzene; Glutathione Transferase; Male; Methylcholanthrene; Mixed Function Oxygenases; Nervous System; Oxidoreductases; Phenobarbital; Rats; Styrene; Styrenes | 1981 |
Immunogenicity of guinea pig cells transformed in culture by chemical carcinogens.
Topics: Animals; Antibody Formation; Antigens, Neoplasm; Benzo(a)pyrene; Benzopyrenes; Cell Transformation, Neoplastic; Clone Cells; Complement Fixation Tests; Fibroblasts; Fluorescent Antibody Technique; Guinea Pigs; Immunity, Cellular; Immunoglobulin G; Male; Methylcholanthrene; Methylnitronitrosoguanidine; Neoplasm Transplantation; Rabbits; Staphylococcal Protein A | 1981 |
A clinically relevant canine lung cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Delayed-Action Preparations; Disease Models, Animal; Dogs; Lung Neoplasms; Methods; Methylcholanthrene; Methylnitrosourea; Neoplasms, Experimental; Radioisotopes; Tetradecanoylphorbol Acetate | 1981 |
Studies on the in vitro transfer of DNA binding benzo[a]pyrene metabolites from rat hepatocytes to human fibroblasts.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Communication; DNA; Fibroblasts; In Vitro Techniques; Liver; Male; Methylcholanthrene; Rats; Rats, Inbred Strains; Time Factors | 1981 |
Activation of benzo(a)pyrene and 2-acetamidofluorene to mutagens by microsomal preparations from different animal species: role of cytochrome P-450 and P-448.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Female; Guinea Pigs; Male; Mesocricetus; Methylcholanthrene; Mice; Microsomes, Liver; Mutagens; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
[Studies on the induction by extracts from airborne particulates of benzo(a)pyrene hydroxylase and the binding of benzo(a)pyrene to DNA in the rat lung in vivo after pertracheal administration (author's transl)].
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Cyclohexanes; DNA; Enzyme Induction; Lung; Methylcholanthrene; Polycyclic Compounds; Rats; Trachea | 1981 |
Mixed function oxidase in the mammary gland and liver microsomes of lactating rats. Effects of 3-methylcholanthrene and beta-naphthoflavone.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Female; Flavonoids; Lactation; Mammary Glands, Animal; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; Oxidoreductases; Pregnancy; Rats; Rats, Inbred Strains | 1982 |
Benzo(a)pyrene phenol production by perfused rat liver and its inhibition by ethanol.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Depression, Chemical; Ethanol; Female; Hydroxylation; Liver; Methylcholanthrene; Microsomes, Liver; Perfusion; Phenols; Rats; Rats, Inbred Strains; Time Factors | 1982 |
Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Inactivation, Metabolic; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
Binding of benzo(a)pyrene to hepatic cytosolic protein enhances its microsomal oxidation.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatography, Gel; Cytosol; Ethanol; Glutathione Transferase; Liver; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Proteins; Rats | 1982 |
Effects of estrogens on aryl hydrocarbon hydroxylase mediated binding of benzo(a) pyrene metabolites to DNA in vitro.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; DNA; Estradiol; Female; Kinetics; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver | 1982 |
DNA methylation levels in normal and chemically-transformed mouse 3T3 cells.
Topics: 5-Methylcytosine; Animals; Base Composition; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chromatography, High Pressure Liquid; Cytosine; DNA; Methylation; Methylcholanthrene; Mice | 1982 |
Anaphase aberrations: a measure of genotoxicity in mutagen-treated fish cells.
Topics: Aminacrine; Anaphase; Animals; Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cells, Cultured; Chromosome Aberrations; Gonads; Methylcholanthrene; Methylnitronitrosoguanidine; Mitomycin; Mitomycins; Mutagenicity Tests; Naphthols; Trout | 1982 |
Rat liver microsomal metabolites of 7-methylbenz[c]acridine.
Topics: Acridines; Animals; Benzo(a)pyrene; Benzopyrenes; Chemical Phenomena; Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Male; Mass Spectrometry; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1982 |
Characteristics of microsomal reduction of benzo[a]pyrene 4,5-oxide.
Topics: Anaerobiosis; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Fractionation; Cytochrome P-450 Enzyme System; Cytosol; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Phenobarbital; Phosphatidylcholines; Rats | 1982 |
Roles of UDP-glucuronosyltransferase in the inactivation of benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Enzyme Induction; Glucuronosyltransferase; Kinetics; Methylcholanthrene; Microsomes; Microsomes, Liver; Phenobarbital; Rats; Structure-Activity Relationship; Substrate Specificity; Tissue Distribution | 1981 |
Metabolism of benzo(a)pyrene and benzo(a)pyrene 4,5-oxide in rabbit lung.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Glutathione Transferase; Lung; Methylcholanthrene; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rabbits | 1981 |
Modulation of epoxide hydrolase activity; effect on the activation of benzo[a] pyrene and its covalent binding to DNA in the nucleus.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cell Nucleus; DNA; Epoxide Hydrolases; Liver; Male; Methylcholanthrene; Rats; Rats, Inbred Strains | 1981 |
Formation of mutagenic metabolites from benzo(a)pyrene and 2-aminoanthracene by the s-9 fraction from the liver of the Northern pike (Esox lucius): inducibility with 3-methylcholanthrene and correlation with benzo[a]pyrene monooxygenase activity.
Topics: Animals; Anthracenes; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Biotransformation; Female; Fishes; Liver; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Time Factors | 1982 |
Anticarcinogenic and cocarcinogenic effects of benzo[e]pyrene and dibenz[a,c]anthracene on skin tumor initiation by polycyclic hydrocarbons.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; DNA; Drug Interactions; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Skin Neoplasms | 1982 |
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Flavonoids; Injections, Intraperitoneal; Methylcholanthrene; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Species differences in the biochemical properties of liver microsomal arylamine and arylamide n-hydroxylases.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cricetinae; Fluorenes; Isomerism; Male; Methylcholanthrene; Metyrapone; Mice; Miconazole; Microsomes, Liver; Mixed Function Oxygenases; Paraoxon; Rats; Species Specificity; Substrate Specificity | 1982 |
Effects of polycyclic hydrocarbons on the induction of chromosomal aberrations in absence of an exogenous metabolic activation system in cultured hamster cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; Methylcholanthrene; Polycyclic Compounds | 1982 |
Hepatic drug metabolizing enzyme activity and tumorigenesis in mice following perinatal exposure to benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Female; Gestational Age; Leukemia L1210; Liver; Male; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Neoplasms, Experimental; Organ Size; Oxidoreductases; Pregnancy; Prenatal Exposure Delayed Effects; Reproduction | 1980 |
Acnegenic activity of 3-methylcholanthrene and benzo[a]pyrene, and a comparative study with 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rabbit and hairless mouse.
Topics: Acne Vulgaris; Animals; Benzo(a)pyrene; Benzopyrenes; Dioxins; Methylcholanthrene; Mice; Mice, Hairless; Polychlorinated Dibenzodioxins; Rabbits; Skin | 1982 |
[Crystalline lens "tumor immunity"].
Topics: Aerobiosis; Animals; Benzo(a)pyrene; Benzopyrenes; Citric Acid Cycle; Epithelium; Eye Neoplasms; Immunity; Lens, Crystalline; Methylcholanthrene; Neoplasms, Experimental; Rabbits | 1982 |
[Electron microscopic study of nuclear inclusions in the cells of experimental malignant lung tumors].
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cell Nucleus; Lung Neoplasms; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Organ Culture Techniques | 1982 |
Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dihydroxydihydrobenzopyrenes; DNA; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Quinones; Rats; Rats, Inbred Strains; Time Factors; Uridine Diphosphate Glucuronic Acid | 1982 |
Systemic excretion of benzo(a)pyrene in the control and microsomally induced rat: the influence of plasma lipoproteins and albumin as carrier molecules.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzopyrenes; Carbon Radioisotopes; Carcinogens; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Humans; Kinetics; Lipoproteins; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Rats, Inbred Strains; Serum Albumin; Tritium | 1983 |
Induction of drug metabolizing enzymes in the liver of diabetic mice.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Diabetes Mellitus, Experimental; Enzyme Induction; In Vitro Techniques; Liver; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital | 1982 |
Comparison of cytochromes P-450 with high activity toward benzo[a]pyrene purified from liver microsomes of beta-naphthoflavone and 3-methylcholanthrene-pretreated rats.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carbon Monoxide; Carcinogens; Cytochrome P-450 Enzyme System; Dithionite; Flavonoids; Immunodiffusion; Immunoelectrophoresis; Male; Methylcholanthrene; Microsomes, Liver; Rats; Substrate Specificity | 1982 |
Effect of vitamin A palmitate on mutagenesis induced by polycyclic aromatic hydrocarbons in human cells.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cell Survival; Diterpenes; Epithelium; Humans; Methylcholanthrene; Mutagenicity Tests; Mutagens; Retinyl Esters; Vitamin A | 1983 |
Clearance of benzo(a)pyrene by isolated rat liver and lung: alterations in perfusion and metabolic capacity.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Kinetics; Liver; Lung; Male; Metabolic Clearance Rate; Methylcholanthrene; Perfusion; Rats; Rats, Inbred Strains | 1983 |
Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit.
Topics: Animals; Arrhythmias, Cardiac; Benzo(a)pyrene; Benzopyrenes; Epinephrine; Ethylene Chlorohydrin; Halothane; Male; Methylcholanthrene; Phenobarbital; Rabbits; Time Factors; Trichloroacetic Acid; Trichloroethylene | 1983 |
Fibroblast cultures of nude mouse skin as targets for transformation by chemical carcinogens.
Topics: Animals; Anthracenes; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Methylcholanthrene; Mice; Mice, Nude; Skin | 1983 |
Covalent binding of benzo[a]pyrene to rat liver cytosolic proteins and its effect on the binding to microsomal proteins.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cytosol; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains | 1983 |
Hematin-mediated increases of benzo(a)pyrene mono-oxygenation in maternal, fetal and placental tissues of inducible and non-inducible mouse strains.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Carcinogens; Enzyme Induction; Female; Fetus; Heme; Hemin; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Placenta; Pregnancy | 1983 |
Purification and characterization of three forms of microsomal cytochrome P-450 in liver from 3-methylcholanthrene-treated guinea pigs.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Chromatography; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Guinea Pigs; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Rats; Spectrum Analysis | 1983 |
Inhibition by 17-alpha-ethinyl estradiol of benzo[a]-pyrene metabolism in isolated adult rat hepatocytes.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; DNA; Ethinyl Estradiol; In Vitro Techniques; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains | 1983 |
Effect of some xenobiotics on kynurenine hydrolase and kynurenine aminotransferase of mouse liver.
Topics: Animals; Aroclors; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinogens; Chlorodiphenyl (54% Chlorine); Chlorpromazine; Female; Hydrolases; Liver; Lyases; Methylcholanthrene; Mice; Phenobarbital; Pyrazoles; Transaminases | 1983 |
Total body clearance of circulating benzo(a)pyrene in conscious rats: effect of pretreatment with 3-methylcholanthrene and the role of liver and lung.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Kinetics; Liver; Lung; Male; Metabolic Clearance Rate; Methylcholanthrene; Rats; Rats, Inbred Strains | 1983 |
Comparison of aryl hydrocarbon hydroxylase activity and inducibility of sister-chromatid exchanges by polycyclic aromatic hydrocarbons in mammalian cell lines.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; Humans; Methylcholanthrene; Polycyclic Compounds; Rats; Sister Chromatid Exchange | 1983 |
Differential metabolism of acetanilide versus ethoxycoumarin and benzo[a]pyrene by two 3-methylcholanthrene-inducible forms of rat liver cytochrome P-450.
Topics: Acetanilides; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
Cell specific activation of benzo[a]pyrene by fibroblasts and hepatocytes.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Carcinogens; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Fibroblasts; Liver; Lung; Male; Methylcholanthrene; Rats; Rats, Inbred Strains | 1983 |
Physicochemical characterization of specific and nonspecific polyaromatic hydrocarbon binders in rat and mouse liver cytosol.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Chromatography, Gel; Cytosol; Kinetics; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Weight; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug | 1983 |
Induction of neoplastic transformation and DNA single-strand breaks in C3H/10T1/2 clone 8 cells by polycyclic hydrocarbons and alkylating agents.
Topics: Alkylating Agents; Animals; Benzo(a)pyrene; Benzopyrenes; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; DNA Repair; Drug Evaluation, Preclinical; Ethyl Methanesulfonate; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Polycyclic Compounds | 1983 |
Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. An in vitro system for the induction of SCEs.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Crossing Over, Genetic; In Vitro Techniques; Kinetics; Liver Neoplasms, Experimental; Methylcholanthrene; Mutagens; Polycyclic Compounds; Sister Chromatid Exchange; Structure-Activity Relationship | 1983 |
Modifications of carcinogen metabolism in hepatic microsomes of suckling young by 3-methylcholanthrene or beta-naphthoflavone administered to lactating rats.
Topics: 2-Acetylaminofluorene; Animal Population Groups; Animals; Animals, Suckling; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinogens; Cytochrome P-450 Enzyme System; Female; Flavonoids; Hydroxylation; Lactation; Methylcholanthrene; Microsomes, Liver; Pregnancy; Rats | 1983 |
The effects of phenobarbital, 3-methylcholanthrene and benzo(a)pyrene on the hydrolysis of xenobiotics in the rat.
Topics: 2-Acetylaminofluorene; Acetanilides; Amidohydrolases; Animals; Aspirin; Benzo(a)pyrene; Benzopyrenes; Carboxylic Ester Hydrolases; Female; Methylcholanthrene; Microsomes, Liver; Nitrophenols; Phenobarbital; Procaine; Rats; Tissue Distribution | 1983 |
Genetic expression of aflatoxin metabolism. Effects of 3-methylcholanthrene and beta-naphthoflavone on hepatic microsomal metabolism and mutagenic activation of aflatoxins.
Topics: Aflatoxins; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Dose-Response Relationship, Drug; Enzyme Induction; Female; Gene Expression Regulation; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microsomes, Liver; Mixed Function Oxygenases; Mutagenicity Tests; Salmonella typhimurium | 1983 |
Highly persistent polycyclic aromatic hydrocarbon-DNA adducts in mouse skin: detection by 32P-postlabeling analysis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Transformation, Neoplastic; DNA; DNA Repair; DNA, Neoplasm; Female; Isotope Labeling; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phosphorus Radioisotopes; Polycyclic Compounds; Skin | 1983 |
Indole-3-carbinol protects against covalent binding of benzo[a]pyrene and N-nitrosodimethylamine metabolites to mouse liver macromolecules.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Dimethylnitrosamine; DNA; Indoles; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred ICR; Phenobarbital; Rats | 1984 |
Distribution and some characteristics of cytochrome P-450 in the kidney.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Fasting; Hydroxylation; In Vitro Techniques; Kidney Tubules, Proximal; Laurates; Male; Methylcholanthrene; Microsomes; Nephrons; Phenobarbital; Rabbits; Rats | 1983 |
A transforming ras gene in tumorigenic guinea pig cell lines initiated by diverse chemical carcinogens.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Line; Cell Transformation, Neoplastic; Diethylnitrosamine; DNA Restriction Enzymes; Gene Expression Regulation; Genes, Viral; Guinea Pigs; Methylcholanthrene; Methylnitronitrosoguanidine; Mice; Oncogenes; Retroviridae | 1984 |
In vitro inhibition of 3-methylcholanthrene-induced rat hepatic aryl hydrocarbon hydroxylase by 8-acyl-7-hydroxycoumarins. Structure-activity relationships and metabolite profiles.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; Enzyme Induction; Epoxide Hydrolases; Liver; Male; Methylcholanthrene; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Umbelliferones | 1984 |
Protection against 3-methylcholanthrene-induced skin tumorigenesis in Balb/C mice by ellagic acid.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrans; Benzopyrenes; Carcinogens; DNA; Ellagic Acid; Female; Methylcholanthrene; Mice; Mice, Inbred BALB C; Skin Neoplasms | 1984 |
Microsome-mediated reactions of phenols of polycyclic hydrocarbons with DNA.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Chromatography; Chrysenes; DNA; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenols; Polycyclic Compounds; Rats; Rats, Inbred Strains | 1984 |
Comparison of hepatic drug-metabolizing enzymes induced by 3-methylcholanthrene and phenobarbital between pre- and postnatal rats.
Topics: Aminopyrine; Animals; Animals, Newborn; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Gestational Age; Hexobarbital; Maternal-Fetal Exchange; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
[Correlation between cytochrome P-448 content and benzopyrene hydroxylase activity during the induction of microsomal monooxygenases using methylcholanthrene-type xenobiotics].
Topics: Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrene Hydroxylase; Benzopyrenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Dioxins; Immunoelectrophoresis; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains | 1984 |
Direct enantiomeric resolution of cyclic alcohol derivatives of polycyclic aromatic hydrocarbons by chiral stationary phase high-performance liquid chromatography.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Chromatography, High Pressure Liquid; Methylcholanthrene; Mutagens; Phenanthrenes; Polycyclic Compounds; Rats; Stereoisomerism | 1984 |
Carcinogenesis, benzo[a]pyrene metabolism, and sister chromatid exchanges in lungs of rats after intratracheal 3-methylcholanthrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Crossing Over, Genetic; Kinetics; Lung; Lung Neoplasms; Male; Methylcholanthrene; Microsomes; Rats; Rats, Inbred F344; Sister Chromatid Exchange | 1984 |
Immunocytotoxicity effects of polycyclic aromatic hydrocarbons on mouse lymphocytes.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Immunity; Lymphocytes; Methylcholanthrene; Mice; Mice, Inbred Strains; Polycyclic Compounds | 1984 |
[Isolation and characterization of the basic forms of cytochrome P-450 from liver microsomes of C57BL mice after phenobarbital and 3-methylcholanthrene induction].
Topics: Aminopyrine; Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Weight; Phenobarbital; Substrate Specificity | 1984 |
Procoagulant activity of macrophages associated with different murine neoplasms.
Topics: Animals; Ascitic Fluid; Benzo(a)pyrene; Blood Coagulation; Carcinoma; Endotoxins; Macrophages; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Neoplasm Transplantation; Neoplasms, Experimental; Salmonella enteritidis; Sarcoma, Experimental | 1984 |
Binding and metabolism of benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene by seven purified forms of cytochrome P-450.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred Strains; Spectrophotometry; Substrate Specificity | 1984 |
[Catalytic activity of cytochrome P-448 in native and reconstituted microsomal membranes].
Topics: Animals; Benzo(a)pyrene; Catalysis; Cytochrome P-450 CYP1A2; Cytochromes; Hydroxylation; Intracellular Membranes; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1984 |
Benzo(a)pyrene activation to 7,8-dihydrodiol 9,10-oxide by rat liver microsomes. Control by selective product inhibition.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Amines; Animals; Benzo(a)pyrene; Benzopyrenes; Cytochrome P-450 Enzyme System; Kinetics; Male; Mathematics; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains | 1984 |
The effects of a cocarcinogen, ferric oxide, on the metabolism of benzo[a]pyrene in the isolated perfused lung.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cocarcinogenesis; Ferric Compounds; In Vitro Techniques; Iron; Lung; Male; Methylcholanthrene; Rabbits | 1984 |
Effect of thiamin deprivation on the in vitro metabolic activation of benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Biotransformation; Carcinogens; Diet; Female; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Rats; Thiamine Deficiency | 1984 |
Regulation of aldehyde dehydrogenase activity in five rat hepatoma cell lines.
Topics: Aldehyde Dehydrogenase; Amanitins; Animals; Benzo(a)pyrene; Cell Line; Cycloheximide; Dactinomycin; Enzyme Induction; Kinetics; Liver Neoplasms, Experimental; Methylcholanthrene; Phenotype; Rats | 1984 |
Influence of red blood cells, serum albumin, and serum lipoproteins on the clearance of benzo[alpha]pyrene by isolated livers of 3-methylcholanthrene-treated rats.
Topics: Animals; Benzo(a)pyrene; Erythrocytes; In Vitro Techniques; Lipoproteins; Liver; Male; Metabolic Clearance Rate; Methylcholanthrene; Rats; Rats, Inbred Strains; Serum Albumin | 1984 |
Epidermal benzo[a]pyrene metabolism and DNA-binding in Balb/C mice: inhibition by ellagic acid.
Topics: Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzopyrans; DNA; Ellagic Acid; Epidermis; Liver; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microsomes | 1984 |
A family of epidermoid lung cancer models.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cricetinae; Disease Models, Animal; DNA; Drug Implants; Lung Neoplasms; Mesocricetus; Methylcholanthrene; Time Factors | 1984 |
Benzo(a)pyrene metabolism in hepatic microsomes from feral and 3-methycholanthrene-treated southern flounder, Paralichthys lethostigma.
Topics: Animals; Benzo(a)pyrene; Benzopyrene Hydroxylase; Enzyme Induction; Fishes; In Vitro Techniques; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Inbred Strains | 1984 |
Todralazine influence upon the mutagenicity of some direct- and indirect-acting mutagens.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Aminacrine; Antimutagenic Agents; Azides; Benzo(a)pyrene; Biotransformation; Daunorubicin; Dose-Response Relationship, Drug; Methyl Methanesulfonate; Methylcholanthrene; Microsomes, Liver; Mitomycin; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Sodium Azide; Todralazine | 1994 |
Detection of DNA adducts in basal and non-basal cells of the hamster trachea exposed to benzo(a)pyrene in organ culture.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cricetinae; DNA Adducts; Epithelial Cells; Epithelium; Fluorescent Antibody Technique; Humans; Keratins; Leukocytes; Mesocricetus; Methylcholanthrene; Organ Culture Techniques; Time Factors; Trachea | 1994 |
Induction and purification of cytochrome P450 1A1 from 3-methylcholanthrene-treated tilapia, Oreochromis niloticus x Oreochromis aureus.
Topics: Amino Acid Sequence; Animals; Benzo(a)pyrene; Blotting, Northern; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Gills; Hydroxylation; Immunoblotting; Liver; Male; Methylcholanthrene; Microsomes; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxygenases; Polychlorinated Biphenyls; Sequence Analysis; Tilapia; Titrimetry | 1995 |
Histogenesis of adenosquamous bronchogenic carcinoma.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Adenosquamous; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Cricetinae; Drug Implants; Lung Neoplasms; Methylcholanthrene | 1995 |
Genotoxic potency in Drosophila melanogaster of selected aromatic amines and polycyclic aromatic hydrocarbons as assayed in the DNA repair test.
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Amines; Animals; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; DNA Repair; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Fluorenes; Genes, Insect; Larva; Male; Methylcholanthrene; Mutagens; Polycyclic Compounds; Pyrenes; Sex Ratio | 1993 |
Transforming growth factor-beta 1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture.
Topics: Adult; Amino Acid Sequence; Base Sequence; Benzo(a)pyrene; Cells, Cultured; Cycloheximide; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Induction; Humans; Kinetics; Liver; Methylcholanthrene; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Oxidoreductases; RNA, Messenger; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta | 1994 |
Involvement of P450 1A1 in benzo(a)pyrene but not in benzo(a)pyrene-7,8-dihydrodiol activation by 3-methylcholanthrene-induced mouse liver microsomes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Cytochrome P-450 Enzyme System; DNA Repair; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Spectrometry, Fluorescence | 1993 |
Induction of cytochrome CYPIA1 and formation of toxic metabolites of benzo[a]pyrene by rat aorta: a possible role in atherogenesis.
Topics: Animals; Aorta; Arteriosclerosis; Benzo(a)pyrene; Biotransformation; Cytochrome P-450 Enzyme System; Enzyme Induction; Male; Methylcholanthrene; Microsomes; Rats; Rats, Sprague-Dawley; Smoking | 1994 |
Ki-ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice.
Topics: Animals; Base Sequence; Benzo(a)pyrene; DNA; Genes, ras; Lung Neoplasms; Methylcholanthrene; Mice; Mice, Inbred A; Molecular Sequence Data; Mutation; Polymerase Chain Reaction | 1993 |
Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Methylcholanthrene; Mice; Mutagens; Papilloma; Pyrenes; Skin Neoplasms | 1993 |
A step section method for full histopathological assessment of carcinogen-affected target tissue during respiratory carcinogenesis.
Topics: Animals; Benzo(a)pyrene; Carcinoma in Situ; Cricetinae; Female; Lung Neoplasms; Male; Metaplasia; Methylcholanthrene; Microtomy; Neoplasm Invasiveness | 1993 |
Morphological transformation of C3H10T1/2CL8 cells by cyclopenta-fused derivatives of benzo[a]pyrene and benzo[e]pyrene.
Topics: Air Pollutants; Analysis of Variance; Animals; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Cell Line, Transformed; Cell Transformation, Neoplastic; Fibroblasts; Methylcholanthrene; Mice; Mice, Inbred C3H; Mutagenicity Tests; Mutagens; Polycyclic Compounds; Structure-Activity Relationship | 1993 |
Regioselective metabolism of benzo[a]pyrene and 7-chlorobenz[a]anthracene by fish liver microsomes.
Topics: Animals; Anthracenes; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases; Spectrophotometry, Ultraviolet; Stereoisomerism; Tilapia | 1994 |
Metabolism of benzo(a)pyrene by lung microsomes from rabbits pretreated with polychlorinated biphenyls and 2,3,4,7,8-pentachlorodibenzofuran.
Topics: Animals; Aroclors; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzofurans; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Lung; Male; Methylcholanthrene; Microsomes; Rabbits | 1993 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma, Hepatocellular; Colonic Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Kinetics; Liver Neoplasms; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases; Phenobarbital; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Induction of cytochrome P450IA1 and its recombinant construct in H4IIE rat hepatoma cells.
Topics: Animals; Benzo(a)pyrene; Benzofurans; Blotting, Western; Carcinoma, Hepatocellular; Chloramphenicol O-Acetyltransferase; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Kinetics; Methylcholanthrene; Oxidoreductases; Rats; Recombinant Proteins; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1993 |
Comparative 32P-postlabeling analysis of benzo[a]pyrene--DNA adducts formed in vitro upon activation of benzo[a]pyrene by human, rabbit and rodent liver microsomes.
Topics: Animals; Benzo(a)pyrene; Cricetinae; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; Female; Humans; Male; Methylcholanthrene; Mice; Microsomes, Liver; Oxidoreductases; Phosphorus Radioisotopes; Rabbits; Rats; Rats, Wistar; Species Specificity | 1993 |
In vivo metabolism of benzo(a)pyrene in a lower vertebrate, the newt Pleurodeles walt.
Topics: Animals; Benzo(a)pyrene; Bile; Biotransformation; Chromatography, High Pressure Liquid; Environmental Pollutants; Half-Life; Injections, Intraperitoneal; Liver; Methylcholanthrene; Pleurodeles; Radiometry | 1995 |
Fetal mouse susceptibility to transplacental carcinogenesis: differential influence of Ah receptor phenotype on effects of 3-methylcholanthrene, 12-dimethylbenz[a]anthracene, and benzo[a]pyrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Crosses, Genetic; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Maternal-Fetal Exchange; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pharmacogenetics; Phenotype; Pregnancy; Receptors, Aryl Hydrocarbon; Risk Factors | 1995 |
Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver.
Topics: Animals; Base Sequence; Benzo(a)pyrene; beta-Naphthoflavone; Carbolines; Carcinogens; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Imidazoles; Male; Methylcholanthrene; Microsomes, Liver; Oligonucleotide Probes; p-Aminoazobenzene; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1996 |
[Organ cytotoxicity of selected polycyclic aromatic hydrocarbons in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Dimethyl Sulfoxide; Female; Kidney; Liver; Lymphoid Tissue; Methylcholanthrene; Mice; Mice, Inbred BALB C; Nucleolus Organizer Region; Organ Size; Polycyclic Compounds | 1997 |
Aneuploidy induction by benzo[a]pyrene and polyploidy induction by 7,12-dimethylbenz[a]anthracene in Chinese hamster cell lines V79-MZ and V79.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aneuploidy; Animals; Benzo(a)pyrene; Cell Cycle; Cell Line; CHO Cells; Chromosome Aberrations; Colchicine; Cricetinae; Cricetulus; Methylcholanthrene; Mitomycin; Mutagens; Polyploidy; Sister Chromatid Exchange | 1997 |
Polycyclic aromatic hydrocarbons enhance terminal cell death of human ectocervical cells.
Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Biotransformation; Carcinogens; Cell Death; Cell Differentiation; Cell Division; Cells, Cultured; Cervix Uteri; DNA Adducts; DNA Damage; Epithelial Cells; Female; Humans; Methylcholanthrene; Papillomaviridae; Polycyclic Aromatic Hydrocarbons; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 1998 |
Metabolism and activation of cyclopenta polycyclic aromatic hydrocarbons in isolated human lymphocytes, HL-60 cells and exposed rats.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Biotransformation; Cyclopentanes; DNA Adducts; DNA Damage; DNA, Single-Stranded; HL-60 Cells; Humans; Lung; Lymphocytes; Male; Methylcholanthrene; Microsomes, Liver; Mutagens; Phosphorus Radioisotopes; Polycyclic Aromatic Hydrocarbons; Rats; Rats, Inbred WKY | 1998 |
Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo[a]pyrene in the Salmonella typhimurium mutagenicity assay in vitro.
Topics: Animals; Benzo(a)pyrene; beta-Naphthoflavone; Blotting, Western; Bromobenzenes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dexamethasone; Enzyme Induction; Lymphocytes; Male; Methylcholanthrene; Mutagenicity Tests; Mutagens; Pyridines; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Smoking | 1999 |
Beta carotene and its oxidation products have different effects on microsome mediated binding of benzo[a]pyrene to DNA.
Topics: Animals; Benzo(a)pyrene; beta Carotene; Cattle; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Spectrophotometry | 1999 |
beta-carotene as enhancer of cell transforming activity of powerful carcinogens and cigarette-smoke condensate on BALB/c 3T3 cells in vitro.
Topics: 3T3 Cells; Animals; Benzo(a)pyrene; beta Carotene; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; Cocarcinogenesis; Drug Synergism; Methylcholanthrene; Mice; Mice, Inbred BALB C; Smoke | 1999 |
Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogens; Cytochrome P-450 CYP1A1; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Retinaldehyde; Retinoids; Tretinoin; Vitamin A | 1999 |
Cytochrome P450 isoforms catalyzing benzo[a]pyrene metabolism in the Chinese hamster liver.
Topics: Animals; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cricetinae; Cricetulus; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; In Vitro Techniques; Isoenzymes; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mutagenicity Tests; Phenobarbital | 1999 |
A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists.
Topics: Animals; Benzo(a)pyrene; Benzoflavones; Benzofurans; beta-Naphthoflavone; Binding, Competitive; Carrier Proteins; Cytochrome P-450 CYP1A1; Cytosol; Female; Glycine N-Methyltransferase; Kinetics; Liver; Methylcholanthrene; Methyltransferases; Molecular Weight; Polychlorinated Dibenzodioxins; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon | 2000 |
Ovotoxicity in female Fischer rats and B6 mice induced by low-dose exposure to three polycyclic aromatic hydrocarbons: comparison through calculation of an ovotoxic index.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Body Weight; Cyclohexanes; Cyclohexenes; Dose-Response Relationship, Drug; Female; Liver; Methylcholanthrene; Mice; Mice, Inbred Strains; Organ Size; Ovarian Follicle; Rats; Rats, Inbred F344; Species Specificity; Vinyl Compounds | 2000 |
Aromatic hydrocarbon receptor (AhR).AhR nuclear translocator- and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo(a)pyrene in hepatoma cells.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzo(a)pyrene; Carcinoma, Hepatocellular; DNA-Binding Proteins; Genes, MDR; Methylcholanthrene; Mice; Models, Biological; Mutation; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Response Elements; RNA, Messenger; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenobiotics | 2001 |
Polycyclic aromatic hydrocarbons as inducers of cytochrome P4501A enzyme activity in the rainbow trout liver cell line, RTL-W1, and in primary cultures of rainbow trout hepatocytes.
Topics: Animals; Benzo(a)pyrene; Cell Line; Cells, Cultured; Cytochrome P-450 CYP1A1; Enzyme Induction; Hepatocytes; Methylcholanthrene; Oncorhynchus mykiss; Polycyclic Aromatic Hydrocarbons | 2001 |
An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene.
Topics: 5' Untranslated Regions; Animals; Base Sequence; Benzo(a)pyrene; beta-Naphthoflavone; Digestive System; DNA, Complementary; Exons; Gene Expression; Glucuronosyltransferase; Humans; Kidney; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Promoter Regions, Genetic; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Thiones; Thiophenes | 2001 |
Immunosuppression and carcinogenesis: contrasting effects with 7,12-dimethylbenz[a]anthracene, benz[a]pyrene, and 3-methylcholanthrene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Antibody Formation; Benzo(a)pyrene; Carcinogens; Immunosuppressive Agents; Lymphoma; Methylcholanthrene; Mice; Thymus Neoplasms; Time Factors | 1970 |
Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription.
Topics: Animals; Base Sequence; Benzo(a)pyrene; Binding Sites; DNA-Directed DNA Polymerase; DNA, Complementary; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Male; Methylcholanthrene; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Proteins; Receptors, Aryl Hydrocarbon; Sequence Homology, Nucleic Acid; Testis; Transcription, Genetic | 2001 |
Quantitative assessment of mutagenic potential of water via EROD-microbioassessment.
Topics: Animals; Benzo(a)pyrene; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Ion Exchange Resins; Korea; Methylcholanthrene; Mice; Mutagens; Polystyrenes; Polyvinyls; Rats; Tumor Cells, Cultured; Water Pollutants, Chemical | 2002 |
Serum increases CYP1A1 induction by 3-methylcholanthrene.
Topics: Adenocarcinoma; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Blood Proteins; Carcinoma; Cattle; Colonic Neoplasms; Cytochrome P-450 CYP1A1; DNA Damage; Enzyme Induction; Humans; Methylcholanthrene; RNA, Messenger; Tumor Cells, Cultured | 2002 |
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; DNA; DNA Adducts; Enzyme Activation; Enzyme Induction; Homozygote; Isotope Labeling; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes, Liver; Phosphorus Isotopes; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon | 2003 |
Differential modulation of cytochrome P-450 1A and P-glycoprotein expression by aryl hydrocarbon receptor agonists and thyroid hormone in Xenopus laevis liver and intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzo(a)pyrene; Blotting, Western; Carcinogens; Cytochrome P-450 CYP1A1; Digestive System Physiological Phenomena; Environmental Pollutants; Liver; Methylcholanthrene; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Xenopus laevis | 2003 |
Studies on the newt test for carcinogenicity. 1. Benzo[a]pyrene, dibenz[a,h] anthracene and 3-methylcholanthrene.
Topics: Animals; Anthracenes; Benzo(a)pyrene; Humans; Methylcholanthrene; Salamandridae | 1961 |
DIFFERENTIAL TOXICITY RESPONSE OF NORMAL AND NEOPLASTIC CELLS IN VITRO TO 3,4-BENZOPYRENE AND 3-METHYLCHOLANTHRENE.
Topics: Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cricetinae; Embryo, Mammalian; Embryo, Nonmammalian; Fetus; Hydrocarbons; In Vitro Techniques; Methylcholanthrene; Mice; Muscles; Neoplasms; Neoplasms, Experimental; Paraffin; Polyomavirus; Research; Tissue Culture Techniques; Toxicology | 1964 |
Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.
Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Cell Line; Cytochrome P-450 CYP1A1; Humans; Interleukin-1; Methylcholanthrene; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; RNA, Messenger; Synovial Fluid; Up-Regulation | 2004 |
Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity.
Topics: Benzo(a)pyrene; Biotransformation; Caco-2 Cells; Caffeine; Cell Line, Tumor; Cell Survival; Coculture Techniques; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Humans; Intestinal Mucosa; Liver; Methylcholanthrene; Toxicity Tests | 2004 |
Embryonic turkey liver: activities of biotransformation enzymes and activation of DNA-reactive carcinogens.
Topics: 2-Acetylaminofluorene; Animal Testing Alternatives; Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Enzymes; Female; Liver; Methylcholanthrene; Methylenebis(chloroaniline); Phenobarbital; Phosphorus Radioisotopes; Quinoxalines; Rats; Rats, Inbred F344; Rats, Wistar; Turkey | 2004 |
The mutagenic effects of 7,12-dimethylbenz[a]anthacene, 3-methylcholanthrene and benzo[a]pyrene to the developing Syrian hamster fetus measured by an in vivo/in vitro mutation assay.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cricetinae; Fetus; Mesocricetus; Methylcholanthrene; Mutagens; Mutation | 2004 |
DRESSA: biosensing of dioxin and dioxin-like chemicals using secreted alkaline phosphatase.
Topics: Alkaline Phosphatase; Animals; Benzo(a)pyrene; beta-Naphthoflavone; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Dioxins; Enzyme Induction; Gene Expression Regulation; Liver Neoplasms; Mammary Tumor Virus, Mouse; Methylcholanthrene; Mice; Plasmids; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Response Elements; Sensitivity and Specificity; Transfection; Tumor Cells, Cultured | 2004 |
Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway.
Topics: Benzo(a)pyrene; beta-Naphthoflavone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; Humans; Hydrogen Peroxide; Ligands; Lipid Peroxidation; Methylcholanthrene; Oxidative Stress; Receptors, Aryl Hydrocarbon; Signal Transduction | 2004 |
Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons.
Topics: Alkaline Phosphatase; Animals; Benzo(a)pyrene; beta-Naphthoflavone; Cell Line, Tumor; Dioxins; Hydrocarbons, Halogenated; Methylcholanthrene; Mice; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Reproducibility of Results; Time Factors | 2005 |
Chemopreventive effects of mustard (Brassica compestris) on chemically induced tumorigenesis in murine forestomach and uterine cervix.
Topics: Administration, Oral; Animals; Benzo(a)pyrene; Brassica; Catalase; Diet; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Transferase; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Methylcholanthrene; Mice; Plant Preparations; Seeds; Stomach Neoplasms; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Uterine Cervical Neoplasms | 2005 |
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alkylating Agents; Animals; Antioxidants; Benzo(a)pyrene; Butylated Hydroxytoluene; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Disease Models, Animal; Ethylnitrosourea; Female; Humans; Incidence; Lung Neoplasms; Male; Methylcholanthrene; Mice; Mice, Transgenic; Oncogene Protein p21(ras) | 2006 |
Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol.
Topics: Animals; Benzo(a)pyrene; Biphenyl Compounds; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Fungicides, Industrial; Kidney; Liver; Lung; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; RNA, Messenger; Salmonella typhimurium; Triazoles | 2006 |
Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.
Topics: Benzo(a)pyrene; Benzofurans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Estrogen Receptor alpha; Flavonoids; Humans; Indoles; Ligands; Methylcholanthrene; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Presenilin-2; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Structure-Activity Relationship | 2006 |
Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure.
Topics: Animals; Benzo(a)pyrene; beta-Naphthoflavone; Biomarkers; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Cytochrome P-450 CYP1A1; Environmental Monitoring; Environmental Pollutants; Enzyme Induction; Glucuronosyltransferase; Green Fluorescent Proteins; Hepatocytes; Humans; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; Transcription, Genetic; Transfection | 2007 |
Glucuronidation and sulfonation, in vitro, of the major endocrine-active metabolites of methoxychlor in the channel catfish, Ictalurus punctatus, and induction following treatment with 3-methylcholanthrene.
Topics: Acetates; Animals; Benzo(a)pyrene; Biotransformation; Female; Glucuronidase; Glucuronides; Hydrocarbons, Chlorinated; Ictaluridae; Intestinal Mucosa; Intestines; Male; Methylcholanthrene; Microsomes; Phenols; Reproducibility of Results; Sulfur Radioisotopes; Water Pollutants, Chemical | 2008 |
[Ah receptor-independent inhibition of gap junction intercellular communications in hepatoma cell culture 27 by polycyclic aromatic hydrocarbons].
Topics: Animals; Benzo(a)pyrene; Carcinogens; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Down-Regulation; Gap Junctions; Gene Deletion; Methylcholanthrene; Neoplasms; Polycyclic Aromatic Hydrocarbons; Rats; Receptors, Aryl Hydrocarbon | 2009 |
3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats.
Topics: Animals; Arachidonic Acid; Benzo(a)pyrene; Cardiomegaly; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Heart; Hydroxyeicosatetraenoic Acids; Ligands; Male; Methylcholanthrene; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Spectrometry, Mass, Electrospray Ionization | 2009 |
CYP1B1 expression in rat testis and Leydig cells is not inducible by aryl hydrocarbon receptor agonists.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Cell Line; Cytochrome P-450 CYP1B1; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Immunoblotting; Leydig Cells; Male; Methylcholanthrene; Mice; Polychlorinated Dibenzodioxins; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon | 2010 |
Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Benzo(a)pyrene; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Induction; Liver; Liver Neoplasms, Experimental; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Oxygenases; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; RNA, Messenger; Xenobiotics | 2010 |
Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs.
Topics: Animals; Benzo(a)pyrene; Cells, Cultured; Environmental Pollutants; Gene Expression; Humans; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Knockout; Nervous System; Neurons; Polychlorinated Dibenzodioxins; Polycyclic Aromatic Hydrocarbons; Receptors, Aryl Hydrocarbon; RNA, Messenger; Signal Transduction; Species Specificity; Stem Cells | 2010 |
Toxicogenomics applied to in vitro carcinogenicity testing with Balb/c 3T3 cells revealed a gene signature predictive of chemical carcinogens.
Topics: 2-Acetylaminofluorene; Animals; BALB 3T3 Cells; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Computational Biology; Gene Expression Regulation, Neoplastic; Methylcholanthrene; Mice; Phenylenediamines; Principal Component Analysis; RNA, Messenger; Toxicogenetics | 2010 |
Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines.
Topics: Benzo(a)pyrene; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA Damage; Fluorenes; Histones; Humans; Immunohistochemistry; Methylcholanthrene; Mutagenicity Tests; Phosphorylation; Polycyclic Aromatic Hydrocarbons | 2010 |
[Activation of transcription factor NF-kappaB by carcinogenic polycyclic aromatic hydricarbons].
Topics: Actins; Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Hepatocellular; Cell Line, Tumor; Genes, Reporter; Humans; I-kappa B Proteins; Liver Neoplasms; Luciferases; Methylcholanthrene; NF-kappa B; Plasmids; Rats; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Transfection | 2011 |
Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct.
Topics: Benzo(a)pyrene; Carbazoles; Forkhead Transcription Factors; Genes, Reporter; Hep G2 Cells; Humans; Luciferases; Methylcholanthrene; Phosphorylation; Receptors, Aryl Hydrocarbon; Response Elements; Signal Transduction; Xenobiotics | 2011 |
Effect of UDP-glucuronic acid on the microsome-mediated binding of benzo(a)pyrene metabolites to calf thymus DNA.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzo(a)pyrene; Benzopyrenes; Dextrans; DNA; Glucuronosyltransferase; Indicators and Reagents; Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Wistar; Uridine Diphosphate Glucuronic Acid | 1980 |
Cigarette smoking, coffee drinking, and ingestion of charcoal-broiled beef as potential modifiers of drug therapy and confounders of clinical trials.
Topics: Animals; Benzo(a)pyrene; Charcoal; Clinical Trials as Topic; Coffee; Food-Drug Interactions; Humans; Inactivation, Metabolic; Male; Meat; Methylcholanthrene; Mice; Pharmaceutical Preparations; Pharmacokinetics; Polycyclic Aromatic Hydrocarbons; Rats; Smoking | 2012 |
Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.
Topics: Adult; Animals; Basic Helix-Loop-Helix Transcription Factors; Benzo(a)pyrene; Cells, Cultured; Cytochrome P-450 CYP1A1; Female; Fibroblasts; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methylcholanthrene; Mice; Middle Aged; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Repressor Proteins; Skin; Young Adult | 2013 |
The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polκ), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; DNA-Directed DNA Polymerase; Environmental Pollutants; Female; Ligands; Liver; Methylcholanthrene; Polychlorinated Dibenzodioxins; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; RNA Polymerase II; RNA, Messenger | 2012 |