3-methylcholanthrene and acetaminophen

3-methylcholanthrene has been researched along with acetaminophen in 59 studies

Research

Studies (59)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (71.19)	18.7374
1990's	9 (15.25)	18.2507
2000's	3 (5.08)	29.6817
2010's	4 (6.78)	24.3611
2020's	1 (1.69)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Hinson, JA; Mitchell, JR; Nelson, SD	1
Connor, TH; Forti, GC; Legator, MS; Sitra, P	1
Andersson, B; Grafström, R; Moldéus, P; Orrenius, S	1
Gaasterland, DE; Jensen, NM; Nebert, DW; Shichi, H	1
Ryan, AJ	1
Aikawa, K; Kitagawa, H; Kobayashi, K; Satoh, T	1
McMurtry, RJ; Mitchell, JR; Snodgrass, WR	1
Lambert, GH; Nebert, DW; Thorgeirsson, SS	1
Beaubien, AR; Thomas, BH; Zeitz, W	1
Lambert, GH; Thorgeirsson, SS	1
Gillette, JR; Mitchell, JR; Snodgrass, WR	1
Felton, JS; Nebert, DW; Thorgeirsson, SS	1
Gillette, JR	2
Awazu, S; Horie, T; Minamide, Y	1
Piotrowski, JK; Skrzypińska-Gawrysiak, M; Sporny, S; Swietlicka, EA; Szymańska, JA	1
Hall, T; Hart, J; Willson, RA	1
Kalhorn, TF; Lee, CA; Nelson, SD; Slattery, JT	1
Donatus, IA; Vermeulen, NP	1
Harris, C; Juchau, MR; Luchtel, DL; Stark, KL	1
Gregus, Z; Klaassen, CD; Madhu, C	1
Bock, KW; Bock-Hennig, BS	1
Moldéus, P; Moore, G; Moore, M; Nelson, S; Orrenius, S; Thor, H	1
Hughes, H; Mitchell, JR; Smith, CV; Tsokos-Kuhn, JO	1
de Vries, J; Redegeld, FA; van Bree, L	1
Farber, JL; Kyle, ME; Miccadei, S; Nakae, D	1
Farber, JL; Kyle, ME; Nakae, D; Serroni, A	1
Farber, JL; Kyle, ME; Leonard, TB; Nakae, D; Rogers, SA; Serroni, A	1
Farber, JL; Nakae, D; Oakes, JW	1
Bosman, P; de Vries, J; van de Straat, R; Vermeulen, NP; Vromans, RM	1
Avaria, M; Basu, PK; Lubek, BM; Wells, PG	1
Basu, PK; Lubek, BM; Wells, PG	1
Lupo, S; Mico, BA; Rush, GF; Yodis, LA	1
Hazama, H; Murase, T; Okuno, H; Sameshima, Y; Shiozaki, Y	1
Brodie, BB; Davis, DC; Gillette, JR; Jollow, DJ; Mitchell, JR; Potter, WZ	2
Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1
Hashimoto, M; Jollow, DJ; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1
Burns, JJ; Conney, AH; Welch, RM	1
Kobayashi, M; Nagashima, H; Nakatsukasa, H; Watanabe, A	1
Albano, E; Biasi, F; Chiarpotto, E; Dianzani, MU; Poli, G	1
Jollow, DJ; Longacre, S; Price, V; Roberts, S; Smith, C	1
Klippert, PJ; Littel, RJ; Noordhoek, J	1
Ioannides, C; Parke, DV; Steele, CM	1
Lieber, CS; Nakano, M; Sato, C	1
Calder, IC; Emslie, KR; Hart, SJ; Tange, JD	1
Batt, AM; Benhamou, JP; Cobert, B; Degott, C; Level, R; Martin, N; Pessayre, D; Wandscheer, JC	1
Claude, JR; Dutertre-Catella, H; Ellouk-Achard, S; Levresse, V; Martin, C; Pham-Huy, C; Thevenin, M; Warnet, JM	1
Harada, T; Hiraishi, H; Ito, Y; Ivey, KJ; Ogonuki, H; Razandi, M; Suzuki, Y; Terano, A	1
Jacqueson, A; Nicod, L; Regnier, A; Richert, L; Viollon, C	1
Maier, P; Milosevic, N; Schawalder, H	1
Hodgson, HJ; Rahman, TM; Selden, AC	1
Ruiz-Ederra, J; Verkman, AS	1
Isobe-Harima, Y; Itamoto, K; Miura, I; Murata, T; Sakaida, I; Segawa, M; Shinoda, K; Taura, Y; Terai, S	1
Falany, CN; Glatt, H; Meinl, W; Swedmark, S; Tibbs, ZE; Tsoi, C	1
McCarty, WJ; Usta, OB; Yarmush, ML	1
Dalrymple, E; DiProspero, TJ; Lockett, MR	1

Reviews

1 review(s) available for 3-methylcholanthrene and acetaminophen

Article	Year
Pharmacokinetic considerations in toxicity testing. Drug metabolism reviews, 1982, Volume: 13, Issue:6 Topics: Acetaminophen; Animals; Cricetinae; Drug Interactions; Kinetics; Liver; Methylcholanthrene; Pharmaceutical Preparations; Rats; Receptors, Drug; Safrole; Toxicology	1982

Other Studies

58 other study(ies) available for 3-methylcholanthrene and acetaminophen

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin. Molecular pharmacology, 1977, Volume: 13, Issue:4 Topics: Acetaminophen; Animals; Cricetinae; Cytochrome P-450 Enzyme System; Glutathione; In Vitro Techniques; Kinetics; Male; Mass Spectrometry; Mesocricetus; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Isotopes; Phenacetin; Phenobarbital	1977
Bile as a source of mutagenic metabolites produced in vivo and detected by Salmonella typhimurium. Environmental mutagenesis, 1979, Volume: 1, Issue:3 Topics: Acetaminophen; Animals; Bile; Biotransformation; Cyclophosphamide; Diethylstilbestrol; Dimethylnitrosamine; Ethylene Dichlorides; Hycanthone; Isoniazid; Male; Methyl Methanesulfonate; Methylcholanthrene; Mutagens; Rats; Salmonella typhimurium; Serum Albumin, Bovine	1979
Xenobiotic metabolism by isolated rat small intestinal cells. Medical biology, 1979, Volume: 57, Issue:5 Topics: Acetaminophen; Animals; Benzopyrenes; Biotransformation; Cell Separation; Coumarins; Cytochrome P-450 Enzyme System; Glucuronates; Harmine; Intestine, Small; Male; Methylcholanthrene; Oxazines; Rats	1979
Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen. Science (New York, N.Y.), 1978, May-05, Volume: 200, Issue:4341 Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Enzyme Induction; Methylcholanthrene; Mice; Mice, Inbred Strains	1978
In a mouse's eye. Postgraduate medicine, 1978, Volume: 64, Issue:1 Topics: Acetaminophen; Animals; Aryl Hydrocarbon Hydroxylases; Cataract; Humans; Methylcholanthrene; Mice; Mice, Inbred Strains	1978
Glutathione depletion by aniline analogs in vitro associated with liver microsomal cytochrome P-450. Japanese journal of pharmacology, 1978, Volume: 28, Issue:5 Topics: Acetaminophen; Aminophenols; Aniline Compounds; Animals; Cytochrome P-450 Enzyme System; Glutathione; Guinea Pigs; In Vitro Techniques; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Rabbits; Rats	1978
Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. Toxicology and applied pharmacology, 1978, Volume: 46, Issue:1 Topics: Acetaminophen; Animals; Chlorides; Cobalt; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; Kidney; Kinetics; Liver; Male; Methylcholanthrene; Microsomes; Protein Binding; Rats	1978
Genetic aspects of toxicity during development. Environmental health perspectives, 1976, Volume: 18 Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Acetaminophen; Alleles; Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Chromosome Mapping; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Fetus; Genes, Dominant; Glutathione; Liver; Methylcholanthrene; Mice; Mice, Inbred Strains; Molecular Biology; Polycyclic Compounds; Pregnancy; Toxicology	1976
Effect of subacute dosing and phenobarbital and 3-methylcholanthrene pretreatment on the metabolism of acetaminophen in rats. Canadian journal of physiology and pharmacology, 1977, Volume: 55, Issue:1 Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Male; Methylcholanthrene; Phenobarbital; Premedication; Rats	1977
Glutathione in the developing mouse liver--I. Developmental curve and depletion after acetaminophen treatment. Biochemical pharmacology, 1976, Aug-01, Volume: 25, Issue:15 Topics: Acetaminophen; Aging; Animals; Female; Fetus; Glutathione; Liver; Methylcholanthrene; Mice; Mice, Inbred Strains; Placenta; Pregnancy; Teratogens; Time Factors	1976
The role of biotransformation in chemical-induced liver injury. Environmental health perspectives, 1976, Volume: 15 Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cricetinae; Furosemide; Glutathione; Guinea Pigs; Humans; In Vitro Techniques; Iproniazid; Isoniazid; Liver Diseases; Methylcholanthrene; Mice; Phenobarbital; Rats	1976
Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice. Molecular pharmacology, 1975, Volume: 11, Issue:2 Topics: 2-Acetylaminofluorene; Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Fluorenes; Hydrocarbons; In Vitro Techniques; Kinetics; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Molecular Biology	1975
Environmental factors in drug metabolism. Federation proceedings, 1976, Volume: 35, Issue:5 Topics: Acetaminophen; Animals; Azo Compounds; Biotransformation; Cytochrome P-450 Enzyme System; Environment; Enzyme Induction; Intestinal Mucosa; Methylcholanthrene; Microsomes, Liver; Phenobarbital	1976
High molecular weight protein aggregates formed in the liver of the rat following large doses of paracetamol. The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:11 Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Electrophoresis, Polyacrylamide Gel; Glutathione; In Vitro Techniques; Lipid Peroxidation; Liver; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; Proteins; Rats; Rats, Wistar	1992
Effects of 3-methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen. Journal of applied toxicology : JAT, 1992, Volume: 12, Issue:6 Topics: Acetaminophen; Alanine Transaminase; Animals; Drug Synergism; Glutathione; Liver; Male; Maleates; Malondialdehyde; Methylcholanthrene; Mice; Mice, Inbred BALB C	1992
The concentration and temporal relationships of acetaminophen-induced changes in intracellular and extracellular total glutathione in freshly isolated hepatocytes from untreated and 3-methylcholanthrene pretreated Sprague-Dawley and Fischer rats. Pharmacology & toxicology, 1991, Volume: 69, Issue:3 Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Glutathione; Liver; Male; Methylcholanthrene; Rats; Rats, Inbred F344; Rats, Inbred Strains; Species Specificity	1991
Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:1 Topics: Acetaminophen; Alanine Transaminase; Animals; Benzoquinones; Body Temperature; Caffeine; Glutathione; Imines; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains; Theobromine; Theophylline	1990
Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12 Topics: Acetaminophen; Animals; Catechols; Cells, Cultured; Curcumin; Glutathione; L-Lactate Dehydrogenase; Lipid Peroxidation; Liver; Male; Methylcholanthrene; Rats; Rats, Inbred Strains	1990
Abnormal neurulation induced by 7-hydroxy-2-acetylaminofluorene and acetaminophen: evidence for catechol metabolites as proximate dysmorphogens. Toxicology and applied pharmacology, 1989, Volume: 101, Issue:3 Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Acetaminophen; Animals; Biological Availability; Catechols; DNA; Embryo, Mammalian; Enzyme Induction; Hydroxyacetylaminofluorene; Inactivation, Metabolic; Liver; Methylcholanthrene; Neural Tube Defects; Organ Culture Techniques; Proteins; Rats	1989
Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: effect of chemicals that alter acetaminophen hepatotoxicity. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Acetaminophen; Animals; Antioxidants; Bile; Biotransformation; Cricetinae; Cysteamine; Liver; Male; Mesocricetus; Methylcholanthrene; Phenobarbital; Prostaglandin Antagonists	1989
Differential induction of human liver UDP-glucuronosyltransferase activities by phenobarbital-type inducers. Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23 Topics: Acetaminophen; Adolescent; Adult; Benzopyrenes; Bilirubin; Carcinoma, Hepatocellular; Enzyme Induction; Female; Glucuronosyltransferase; Humans; Hydroquinones; Hymecromone; Isoenzymes; Liver Neoplasms; Male; Methylcholanthrene; Microsomes, Liver; Middle Aged; Naphthols; Pentobarbital; Phenytoin; Tumor Cells, Cultured	1987
The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. The Journal of biological chemistry, 1985, Oct-25, Volume: 260, Issue:24 Topics: Acetaminophen; Animals; Benzoquinones; Calcium; Calcium-Transporting ATPases; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytosol; Homeostasis; Imines; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NAD; Oxidation-Reduction; Phosphorylase a; Rats; Rats, Inbred Strains; Sulfhydryl Compounds	1985
Alkylating toxins and the liver plasma membrane calcium pump/calcium atpase. Advances in experimental medicine and biology, 1988, Volume: 232 Topics: Acetaminophen; Animals; Bromobenzenes; Calcium; Calcium-Transporting ATPases; Carbon Tetrachloride; Cell Membrane; Homeostasis; Kinetics; Liver; Male; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains	1988
The 3-methylcholanthrene-mimetic effect of 4,4'-dichlorobiphenyl-treatment on phenacetin-induced hepatic glutathione depletion and liver microsomal phenacetin O-deethylation in rats. Toxicology, 1986, Dec-15, Volume: 42, Issue:2-3 Topics: Acetaminophen; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Glutathione; Liver; Male; Methylcholanthrene; Oxidoreductases; Phenacetin; Phenobarbital; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains	1986
Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochemical and biophysical research communications, 1987, Dec-31, Volume: 149, Issue:3 Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Carmustine; Catalase; Chlorides; Deferoxamine; Drug Resistance; Ferric Compounds; Ferrous Compounds; Free Radicals; Liver; Male; Mannitol; Methylcholanthrene; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Superoxide Dismutase	1987
1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals. Molecular pharmacology, 1988, Volume: 34, Issue:4 Topics: Acetaminophen; Acetone; Carmustine; Cell Survival; Deferoxamine; Drug Synergism; Enzyme Induction; Glutathione; Liver; Male; Maleates; Methylcholanthrene; Phenobarbital; Phenylenediamines	1988
Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes. Archives of biochemistry and biophysics, 1988, Volume: 267, Issue:2 Topics: Acetaminophen; Animals; Carmustine; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Lipid Peroxides; Liver; Male; Membrane Lipids; Methylcholanthrene; Phenylenediamines; Phospholipids; Rats; Rats, Inbred Strains; Time Factors	1988
Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea. Archives of biochemistry and biophysics, 1988, Volume: 267, Issue:2 Topics: Acetaminophen; Animals; Carmustine; Chemical and Drug Induced Liver Injury; Deferoxamine; Drug Synergism; Glutathione Reductase; Male; Methylcholanthrene; Rats; Rats, Inbred Strains	1988
Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol. Chemico-biological interactions, 1988, Volume: 64, Issue:3 Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Electron Transport; Free Radicals; Glutathione; Glutathione Disulfide; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Oxygen; Pyridines; Rats; Rats, Inbred Strains	1988
Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits. Fundamental and applied toxicology : official journal of the Society of Toxicology, 1988, Volume: 10, Issue:4 Topics: Acetaminophen; Animals; Cataract; Chemical and Drug Induced Liver Injury; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Phenobarbital; Rabbits	1988
Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL/6) and resistant (DBA/2) murine strains. Toxicology and applied pharmacology, 1988, Volume: 94, Issue:3 Topics: Acetaminophen; Animals; Biotransformation; Cataract; Cytochrome P-450 CYP1A2; Cytochromes; Glucuronates; Glutathione; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Species Specificity	1988
In vivo and in vitro hepatotoxicity and metabolism of acetaminophen in Syrian hamsters. Toxicology, 1987, Volume: 44, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Animals; Chromatography, High Pressure Liquid; Cricetinae; Enzyme Induction; In Vitro Techniques; Kinetics; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Methylcholanthrene; Phenobarbital	1987
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury. Japanese journal of pharmacology, 1986, Volume: 41, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione; Liver; Liver Diseases; Male; Methylcholanthrene; Microsomes, Liver; Ranitidine; Rats; Thiazoles	1986
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Cobalt; Cyanides; Cytochrome P-450 Enzyme System; Fluorenes; In Vitro Techniques; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADP; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Time Factors; Tritium	1973
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding. Biochemical pharmacology, 1974, Nov-01, Volume: 23, Issue:21 Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; Enzymes; Glucuronates; Glutathione; Half-Life; Intestinal Absorption; Kidney; Kinetics; Liver Diseases; Metabolism; Methylcholanthrene; Mice; Models, Theoretical; Necrosis; Phenobarbital; Proadifen; Rats; Regional Blood Flow; Sulfates; Toxicology	1974
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. Pharmacology, 1974, Volume: 12, Issue:3 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Glutathione; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes, Liver; Necrosis; Phenobarbital; Piperonyl Butoxide; Protein Binding; Rats; Stimulation, Chemical	1974
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. Pharmacology, 1974, Volume: 12, Issue:4-5 Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass Spectrometry; Methylcholanthrene; Mice; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Stimulation, Chemical; Tritium	1974
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. The Journal of pharmacology and experimental therapeutics, 1973, Volume: 187, Issue:1 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Kidney; Lethal Dose 50; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Necrosis; Phenobarbital; Piperonyl Butoxide; Rats; Species Specificity; Time Factors; Tritium	1973
The metabolism of acetophenetidin and N-acetyl-p-aminophenol in the cat. Biochemical pharmacology, 1966, Volume: 15, Issue:5 Topics: Acetaminophen; Animals; Cats; Chromatography; Dogs; Glucuronates; Liver; Male; Methemoglobinemia; Methylcholanthrene; Phenacetin; Rats	1966
Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol. Acta medica Okayama, 1984, Volume: 38, Issue:5 Topics: Acetaminophen; Alanine Transaminase; Alcohols; Animals; Carbon Tetrachloride; Drug Synergism; Ethanol; Liver; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Phenylethyl Alcohol; Rats; Rats, Inbred Strains	1984
Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes. Chemico-biological interactions, 1983, Volume: 47, Issue:3 Topics: Acetaminophen; Animals; Drug Interactions; Glutathione; In Vitro Techniques; Lipid Peroxides; Liver; Male; Malondialdehyde; Methylcholanthrene; Mice; Rats; Rats, Inbred Strains; Time Factors	1983
In vivo O-de-ethylation of phenacetin in 3-methylcholanthrene-pretreated rats: gut wall and liver first-pass metabolism. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 225, Issue:1 Topics: Acetaminophen; Animals; Biological Availability; Intestinal Absorption; Intestinal Mucosa; Kinetics; Liver; Male; Methylcholanthrene; Phenacetin; Rats; Rats, Inbred Strains	1983
Species variation in the metabolic activation of paracetamol to toxic intermediates: role of cytochromes p-450 and p-448. Toxicology letters, 1983, Volume: 16, Issue:1-2 Topics: Acetaminophen; Animals; Biotransformation; Cricetinae; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cytochromes; Humans; Male; Mesocricetus; Methylcholanthrene; Mice; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Swine	1983
Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:3 Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Ethanol; Glutamate Dehydrogenase; Male; Methylcholanthrene; Rats	1981
Induction of paracetamol metabolism in the isolated perfused kidney. Xenobiotica; the fate of foreign compounds in biological systems, 1981, Volume: 11, Issue:9 Topics: Absorption; Acetaminophen; Animals; Chromatography, High Pressure Liquid; Glomerular Filtration Rate; Glutathione; Kidney; Male; Methylcholanthrene; Perfusion; Rats; Sodium	1981
Additive effects of inducers and fasting on acetaminophen hepatotoxicity. Biochemical pharmacology, 1980, Aug-15, Volume: 29, Issue:16 Topics: Acetaminophen; Animals; Enzyme Induction; Fasting; Glutathione; Liver; Male; Methylcholanthrene; Phenobarbital; Rats	1980
Ex vivo and in vitro models in acetaminophen hepatotoxicity studies. Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1995, Volume: 17 Topics: Acetaminophen; Animals; Calcium; Carmustine; Chemical and Drug Induced Liver Injury; Cytosol; Energy Metabolism; Glutathione; Glutathione Reductase; Homeostasis; Male; Methylcholanthrene; Oxidative Stress; Rats; Rats, Wistar	1995
Role of iron and glutathione redox cycle in acetaminophen-induced cytotoxicity to cultured rat hepatocytes. Digestive diseases and sciences, 1994, Volume: 39, Issue:6 Topics: Acetaminophen; Amitrole; Animals; Carmustine; Catalase; Cells, Cultured; Chromium Radioisotopes; Cytochrome P-450 Enzyme System; Deferoxamine; Glutathione; Glutathione Reductase; Iron; L-Lactate Dehydrogenase; Liver; Male; Maleates; Methylcholanthrene; Oxidation-Reduction; Phenanthrolines; Rats; Rats, Sprague-Dawley	1994
Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells. Human & experimental toxicology, 1997, Volume: 16, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antitubercular Agents; Carcinoma, Hepatocellular; Cell Survival; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Glutathione; Humans; Isoniazid; Liver Neoplasms; Methylcholanthrene; Rifampin; Tumor Cells, Cultured	1997
Kupffer cell-mediated differential down-regulation of cytochrome P450 metabolism in rat hepatocytes. European journal of pharmacology, 1999, Feb-26, Volume: 368, Issue:1 Topics: Acetaminophen; Acute-Phase Proteins; Albumins; Analgesics, Non-Narcotic; Animals; Carcinogens; Cell Survival; Cells, Cultured; Coculture Techniques; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Down-Regulation; Isoenzymes; Kupffer Cells; Lipopolysaccharides; Liver; Male; Methylcholanthrene; Nitric Oxide; Phenobarbital; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Xenobiotics	1999
A novel model of acetaminophen-induced acute hepatic failure in rabbits. The Journal of surgical research, 2002, Volume: 106, Issue:2 Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Animal; Drug Synergism; Glutathione; Hepatic Encephalopathy; Injections, Intravenous; Injections, Subcutaneous; Liver; Liver Failure; Male; Methylcholanthrene; Phenobarbital; Rabbits	2002
Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice. Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:9 Topics: Acetaminophen; Animals; Aquaporin 1; Body Water; Cataract; Drug Combinations; Epithelial Cells; Fluoresceins; Immunoblotting; Immunoenzyme Techniques; Lens, Crystalline; Methylcholanthrene; Mice; Mice, Knockout; Mice, Transgenic	2006
A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder. Liver international : official journal of the International Association for the Study of the Liver, 2008, Volume: 28, Issue:1 Topics: Acetaminophen; Amino Acids; Animals; Astrocytes; Blotting, Western; Brain; Disease Models, Animal; Electric Stimulation; Hepatic Encephalopathy; Immunohistochemistry; Male; Methylcholanthrene; Psychomotor Performance; Rats; Rats, Wistar	2008
Highly selective bioactivation of 1- and 2-hydroxy-3-methylcholanthrene to mutagens by individual human and other mammalian sulphotransferases expressed in Salmonella typhimurium. Mutagenesis, 2013, Volume: 28, Issue:5 Topics: Acetaminophen; Animals; Arylsulfotransferase; Dogs; Enzyme Inhibitors; Humans; Isomerism; Methylcholanthrene; Mice; Molecular Docking Simulation; Mutagenicity Tests; Mutagens; Rats; Recombinant Proteins; Salmonella typhimurium; Species Specificity; Sulfotransferases	2013
A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation. Scientific reports, 2016, 05-31, Volume: 6 Topics: Acetaminophen; Animals; Cell Culture Techniques; Cells, Cultured; Ethanol; Female; Glucagon; Glucose; Hepatocytes; Insulin; Lab-On-A-Chip Devices; Methylcholanthrene; Microtechnology; Nitrogen; Rats, Inbred Lew	2016
Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells. Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 74 Topics: Acetaminophen; Aflatoxin B1; Arylsulfotransferase; Cell Culture Techniques; Cell Hypoxia; Cell Survival; Cyclophosphamide; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hep G2 Cells; Humans; Methylcholanthrene; Oxygen; Polychlorinated Dibenzodioxins	2021