3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and varenicline

3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with varenicline in 2 studies

Compound Research Comparison

Studies (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole)	Trials (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole)	Recent Studies (post-2010) (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole)	Studies (varenicline)	Trials (varenicline)	Recent Studies (post-2010) (varenicline)
68	2	18	1,597	381	1,154

Protein Interaction Comparison

Protein	Taxonomy	varenicline (IC50)
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	0.2
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	0.2
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	0.0672
Neuronal acetylcholine receptor subunit beta-4	Homo sapiens (human)	0.11
Neuronal acetylcholine receptor subunit alpha-3	Homo sapiens (human)	0.11
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	0.0672

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brunner, D; Caldarone, B; Eaton, JB; Fedolak, A; Hanania, T; Kozikowski, AP; Lukas, RJ; Tückmantel, W; Yu, LF	1
Barr, JD; Bevins, RA; Murray, JE; Reichel, CM	1

Other Studies

2 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and varenicline

Article	Year
Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. Journal of medicinal chemistry, 2012, Jan-26, Volume: 55, Issue:2 Topics: Animals; Antidepressive Agents; Blood Proteins; Cytochrome P-450 Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Nicotinic Agonists; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship	2012
Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine. Neuropharmacology, 2010, Volume: 58, Issue:8 Topics: Animals; Benzazepines; Conditioning, Classical; Discrimination, Psychological; Extinction, Psychological; Generalization, Psychological; Isoxazoles; Ligands; Male; Nicotine; Nicotinic Agonists; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Varenicline	2010

Article

Year

Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.

Journal of medicinal chemistry, 2012, Jan-26, Volume: 55, Issue:2

Topics: Animals; Antidepressive Agents; Blood Proteins; Cytochrome P-450 Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Nicotinic Agonists; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2012

Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.

Neuropharmacology, 2010, Volume: 58, Issue:8

Topics: Animals; Benzazepines; Conditioning, Classical; Discrimination, Psychological; Extinction, Psychological; Generalization, Psychological; Isoxazoles; Ligands; Male; Nicotine; Nicotinic Agonists; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Varenicline

2010