3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with nicotine in 29 studies
| Studies (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Trials (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Recent Studies (post-2010) (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Studies (nicotine) | Trials (nicotine) | Recent Studies (post-2010) (nicotine) |
|---|---|---|---|---|---|
| 68 | 2 | 18 | 28,519 | 2,280 | 9,302 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (72.41) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, DJ; Carrera, GM; Elliott, RL; Garvey, DS; He, Y; Hettinger, AM; Holladay, MW; Lebold, SA; Lin, NH; Wasicak, JT | 1 |
| Arneric, SP; Brioni, JD; Buckley, MJ; Carrera, GM; Decker, MW; Garvey, DS; Holladay, MW; Sullivan, JP; Wasicak, JT; Williams, M | 1 |
| Anderson, DJ; Arneric, SP; Brioni, JD; Buccafusco, JJ; Buckley, MJ; Decker, MW; Donnelly-Roberts, DL; Garvey, DS; Gunn, DE; Holladay, MW; Lin, NH; Marsh, KG; Prendergast, MA; Rodrigues, AD; Ryther, KB; Sullivan, JP; Williams, M | 1 |
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Begtrup, M; Christensen, B; Ehrbar, U; Hansen, JB; Olesen, PH; Pettersson, I; Rimvall, K; Tønder, JE | 1 |
| Bolchi, C; Clementi, F; Fumagalli, L; Gotti, C; Moroni, B; Pallavicini, M; Vailati, S; Valoti, E; Villa, L | 1 |
| Clementi, F; Dallanoce, C; De Amici, M; De Micheli, C; Gotti, C; Lo Presti, L; Magrone, P; Matera, C; Riganti, L | 1 |
| Brunner, D; Caldarone, B; Eaton, JB; Fedolak, A; Hanania, T; Kozikowski, AP; Lukas, RJ; Tückmantel, W; Yu, LF | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Arneric, SP; Brioni, JD; Brodie, MS; Decker, MW; Kim, DJ | 1 |
| Adams, P; Anderson, DJ; Arneric, SP; Briggs, CA; Cadman, ED; Donnelly-Roberts, D; Garvey, DS; Hughes, ML; Raszkiewicz, JL; Sullivan, JP | 1 |
| Holley, LA; Sarter, M; Turchi, J | 1 |
| Brioni, JD; Buckley, MJ; Decker, MW; Giardina, WJ; Kang, CH; Kim, DJ; Radek, RJ; Raszkiewicz, JL; Sullivan, JP; Wasicak, JT | 1 |
| Arneric, SP; Brioni, JD; Buckley, MJ; Decker, MW; Kim, DJ; O'Neill, AB | 1 |
| Arneric, SP; Buccafusco, JJ; Decker, MW; Jackson, WJ; Marsh, KC; Terry, AV | 1 |
| Arneric, SP; Bannon, AW; Briggs, CA; Brioni, JD; Decker, MW; Donnelly-Roberts, D; Kyncl, J; Marsh, KC; Radek, RJ; Sullivan, JP | 1 |
| Aceto, MD; Creasy, KR; Damaj, MI; Martin, BR; Rosecrans, JA; Welch, SP | 1 |
| Nordberg, A; Warpman, U | 1 |
| Badio, B; Daly, JW; Garraffo, HM; Padgett, WL; Plummer, CV | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y; Tsuneyoshi, A | 1 |
| Stevens, KE; Wear, KD | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS | 1 |
| Arneric, SP; Buccafusco, JJ; Decker, MW; Jackson, WJ; Prendergast, MA; Terry, AV | 1 |
| Bergström, M; Bivehed, H; Fasth, KJ; Långström, B; Nordberg, A; Ogren, M; Sihver, W; Watanabe, Y | 1 |
| Bergström, M; Fasth, KJ; Långström, B; Lundqvist, H; Nordberg, A; Ogren, M; Sihver, W; Watanabe, Y | 1 |
| Bubl, B; Feuerstein, TJ; Hubbe, U; Huethe, F; Jackisch, R; Löffler, M; McIntosh, JM | 1 |
| Barr, JD; Bevins, RA; Murray, JE; Reichel, CM | 1 |
| Geyer, MA; Meves, JM; Young, JW | 1 |
2 review(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and nicotine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
27 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and nicotine
| Article | Year |
|---|---|
Ligands for brain cholinergic channel receptors: synthesis and in vitro characterization of novel isoxazoles and isothiazoles as bioisosteric replacements for the pyridine ring in nicotine.
Topics: Animals; Brain; Dopamine; Isoxazoles; Ligands; Nicotinic Agonists; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Thiazoles | 1994 |
Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding Sites; Brain; Bungarotoxins; Cognition; Isoxazoles; Mice; Molecular Structure; Motor Activity; Nicotine; Quinolizines; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Stereoisomerism | 1994 |
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.
Topics: Administration, Oral; Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Biological Availability; Bungarotoxins; Cell Line; Cognition; Dogs; Haplorhini; Humans; Hypothermia; Isoxazoles; Ligands; Maze Learning; Mice; Molecular Structure; Psychomotor Performance; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Rubidium; Structure-Activity Relationship | 1997 |
Improving the nicotinic pharmacophore with a series of (Isoxazole)methylene-1-azacyclic compounds: synthesis, structure-activity relationship, and molecular modeling.
Topics: Animals; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Hydrogen Bonding; Isoxazoles; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotine; Nitrogen; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Static Electricity; Structure-Activity Relationship; Thermodynamics | 1999 |
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers.
Topics: Animals; Cerebral Cortex; Imines; Proline; Protein Binding; Pyrrolidines; Rats; Receptors, Nicotinic | 2004 |
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.
Topics: Crystallography, X-Ray; Isoxazoles; Models, Molecular; Molecular Conformation; Neurons; Pyrrolidines; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2010 |
Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
Topics: Animals; Antidepressive Agents; Blood Proteins; Cytochrome P-450 Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Nicotinic Agonists; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2012 |
ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Electrophysiology; Isoxazoles; Male; Mecamylamine; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Time Factors; Ventral Tegmental Area | 1995 |
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Cognition; Corpus Striatum; Dopamine; Ion Channels; Isoxazoles; Kinetics; Male; Mice; Nicotine; Parasympathomimetics; PC12 Cells; Pyrrolidines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Nicotinic; Rubidium; Rubidium Radioisotopes; Tritium | 1994 |
Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Attention; Behavior, Animal; Isoxazoles; Ligands; Lobeline; Mecamylamine; Nicotine; Pyrrolidines; Rats; Receptors, Nicotinic; Time Factors | 1995 |
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.
Topics: Alzheimer Disease; Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Behavior, Animal; Body Temperature; Brain; Cerebrovascular Circulation; Cognition; Electroencephalography; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nociceptors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cholinergic; Seizures; Vomiting | 1994 |
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1994 |
Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: a novel cholinergic channel activator for memory enhancement.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response Relationship, Drug; Isoxazoles; Learning; Macaca mulatta; Male; Memory; Nicotine; Pyrrolidines; Receptors, Nicotinic; Task Performance and Analysis; Time Factors | 1995 |
Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties.
Topics: Alzheimer Disease; Animals; Anti-Anxiety Agents; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Isoxazoles; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats | 1995 |
Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Discrimination, Psychological; Dose-Response Relationship, Drug; Isoxazoles; Locomotion; Male; Mice; Mice, Inbred ICR; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection | 1995 |
Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Ganglia; Isoxazoles; Kinetics; Male; Mice; Nicotine; Nicotinic Agonists; Nociceptors; PC12 Cells; Pyrrolidines; Rats; Receptors, Nicotinic; Tritium | 1997 |
Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Dopamine; Isoxazoles; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyrrolidines; Quinolizines; Serotonin; Tacrine | 1997 |
Normalizing effects of nicotine and a novel nicotinic agonist on hippocampal auditory gating in two animal models.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Conditioning, Psychological; Evoked Potentials, Auditory; Female; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred DBA; Microelectrodes; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1997 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys.
Topics: Animals; Anti-Anxiety Agents; Attention; Cholinergic Agents; Dose-Response Relationship, Drug; Female; Isoxazoles; Macaca mulatta; Macaca nemestrina; Male; Mental Recall; Nicotine; Nicotinic Agonists; Photic Stimulation; Pyridines; Pyrrolidines; Receptors, Nicotinic | 1998 |
In vitro evaluation of 11C-labeled (S)-nicotine, (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, and (R,S)-1-methyl-2-(3-pyridyl)azetidine as nicotinic receptor ligands for positron emission tomography studies.
Topics: Animals; Azetidines; Binding Sites; Brain; Carbon Radioisotopes; Isoxazoles; Ligands; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tomography, Emission-Computed | 1998 |
In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(-)[11C]nicotine in rhesus monkeys.
Topics: Animals; Azetidines; Brain; Carbon Radioisotopes; Cerebellum; Isoxazoles; Macaca mulatta; Nicotine; Organ Specificity; Pyrrolidines; Radiopharmaceuticals; Temporal Lobe; Thalamus; Tomography, Emission-Computed | 1999 |
Health news. The sleeper syndrome.
Topics: Alzheimer Disease; Cacao; Humans; Hygiene; Isoxazoles; Margarine; Nicotine; Parkinson Disease; Pyrrolidines; Superoxides | 2001 |
Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adolescent; Adult; Aged; Alkaloids; Analysis of Variance; Animals; Autoreceptors; Azocines; Calcium; Child; Child, Preschool; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Feedback; Female; Fluvoxamine; Humans; In Vitro Techniques; Isoxazoles; Male; Maprotiline; Mice; Middle Aged; Neocortex; Nicotine; Nicotinic Antagonists; Potassium; Pyrrolidines; Quinolizines; Rats; Receptors, Nicotinic; Sulpiride; Time Factors; Tritium | 2006 |
Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.
Topics: Animals; Benzazepines; Conditioning, Classical; Discrimination, Psychological; Extinction, Psychological; Generalization, Psychological; Isoxazoles; Ligands; Male; Nicotine; Nicotinic Agonists; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Varenicline | 2010 |
Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Choice Behavior; Cholinergic Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Psychomotor Performance; Pyrrolidines; Receptors, Nicotinic; Scopolamine | 2013 |