Compounds > 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole
Page last updated: 2024-09-03

3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and mecamylamine

3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with mecamylamine in 5 studies

Compound Research Comparison

Studies
(3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole)		Trials
(3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole)		Recent Studies (post-2010)
(3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole)		Studies
(mecamylamine)		Trials
(mecamylamine)		Recent Studies (post-2010) (mecamylamine)
682181,99768376

Protein Interaction Comparison

ProteinTaxonomy3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (IC50)mecamylamine (IC50)
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)0.44
Neuronal acetylcholine receptor subunit beta-4Homo sapiens (human)2.0833
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)1.6133
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)1.8
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)0.6
Neuronal acetylcholine receptor subunit alpha-2Homo sapiens (human)3.1

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dart, MJ; Holladay, MW; Lynch, JK1
Arneric, SP; Brioni, JD; Brodie, MS; Decker, MW; Kim, DJ1
Holley, LA; Sarter, M; Turchi, J1
Arneric, SP; Brioni, JD; Buckley, MJ; Decker, MW; Kim, DJ; O'Neill, AB1
Imoto, M; Ohno, T; Saito, K; Tani, Y; Tsuneyoshi, A1

Reviews

1 review(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and mecamylamine

ArticleYear
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship

1997

Other Studies

4 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and mecamylamine

ArticleYear
ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity.
    Psychopharmacology, 1995, Volume: 119, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Electrophysiology; Isoxazoles; Male; Mecamylamine; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Time Factors; Ventral Tegmental Area

1995
Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats.
    Psychopharmacology, 1995, Volume: 118, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Arousal; Attention; Behavior, Animal; Isoxazoles; Ligands; Lobeline; Mecamylamine; Nicotine; Pyrrolidines; Rats; Receptors, Nicotinic; Time Factors

1995
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome

1994
Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice.
    Psychopharmacology, 1997, Volume: 129, Issue:3

    Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Dopamine; Isoxazoles; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyrrolidines; Quinolizines; Serotonin; Tacrine

1997