3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with isoxazoles in 49 studies
| Studies (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Trials (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Recent Studies (post-2010) (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Studies (isoxazoles) | Trials (isoxazoles) | Recent Studies (post-2010) (isoxazoles) |
|---|---|---|---|---|---|
| 68 | 2 | 18 | 8,633 | 900 | 3,337 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (59.18) | 18.2507 |
| 2000's | 8 (16.33) | 29.6817 |
| 2010's | 12 (24.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, DJ; Arneric, SP; Bannon, AW; Briggs, CA; Brioni, JD; Decker, MW; Donnelly-Roberts, D; Holladay, MW; Sullivan, JP; Williams, M | 1 |
| Arneric, SP; Brioni, JD; Brodie, MS; Decker, MW; Kim, DJ | 1 |
| Adams, P; Anderson, DJ; Arneric, SP; Briggs, CA; Cadman, ED; Donnelly-Roberts, D; Garvey, DS; Hughes, ML; Raszkiewicz, JL; Sullivan, JP | 1 |
| Briggs, CA; McKenna, DG; Piattoni-Kaplan, M | 1 |
| Holley, LA; Sarter, M; Turchi, J | 1 |
| Anderson, DJ; Arneric, SP; Campbell, JE; Pauly, JR; Raszkiewicz, JL; Rotert, G; Surber, B; Thomas, SB; Wasicak, J; Williams, M | 1 |
| Brioni, JD; Buckley, MJ; Decker, MW; Giardina, WJ; Kang, CH; Kim, DJ; Radek, RJ; Raszkiewicz, JL; Sullivan, JP; Wasicak, JT | 1 |
| Arneric, SP; Brioni, JD; Buckley, MJ; Decker, MW; Kim, DJ; O'Neill, AB | 1 |
| Arnerić, SP; Brioni, JD; Curzon, P; Decker, MW | 1 |
| Arneric, SP; Buccafusco, JJ; Decker, MW; Jackson, WJ; Marsh, KC; Terry, AV | 1 |
| Arneric, SP; Bannon, AW; Briggs, CA; Brioni, JD; Decker, MW; Donnelly-Roberts, D; Kyncl, J; Marsh, KC; Radek, RJ; Sullivan, JP | 1 |
| Aceto, MD; Creasy, KR; Damaj, MI; Martin, BR; Rosecrans, JA; Welch, SP | 1 |
| Cashman, JR; Ferrero, JL; Kukulka, MJ; Rodrigues, AD | 1 |
| Nordberg, A; Warpman, U | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP; Xue, IC | 1 |
| Anderson, DJ; Arneric, SP; Brioni, JD; Buccafusco, JJ; Buckley, MJ; Decker, MW; Donnelly-Roberts, DL; Garvey, DS; Gunn, DE; Holladay, MW; Lin, NH; Marsh, KG; Prendergast, MA; Rodrigues, AD; Ryther, KB; Sullivan, JP; Williams, M | 1 |
| Meyer, EM; Moulton, BA; Papke, RL; Poirier, A; Thinschmidt, JS | 1 |
| Badio, B; Daly, JW; Garraffo, HM; Padgett, WL; Plummer, CV | 1 |
| Bottlaender, M; Crouzel, C; Dolci, L; Dollé, F; Syrota, A; Valette, H | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y; Tsuneyoshi, A | 1 |
| Arneric, SP; Buccafusco, JJ; Decker, MW; Jackson, WJ; Marsh, KC; Prendergast, MA; Terry, AV | 1 |
| Stevens, KE; Wear, KD | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS | 1 |
| Arneric, SP; Buccafusco, JJ; Decker, MW; Jackson, WJ; Prendergast, MA; Terry, AV | 1 |
| Bergström, M; Bivehed, H; Fasth, KJ; Långström, B; Nordberg, A; Ogren, M; Sihver, W; Watanabe, Y | 1 |
| Corwin, J; Lang, J; Lenox, R; Newhouse, PA; Piasecki, M; Potter, A | 1 |
| Decker, MW; McGaughy, J; Sarter, M | 1 |
| Bergström, M; Fasth, KJ; Långström, B; Lundqvist, H; Nordberg, A; Ogren, M; Sihver, W; Watanabe, Y | 1 |
| Abrams, A; Biederman, J; Bostic, J; Fine, C; Monuteaux, MC; Polisner, D; Prince, J; Rater, M; Soriano, J; Spencer, TJ; Wilens, TE | 1 |
| Horrigan, JP | 1 |
| Bennani, YL; Black, LA; Decker, MW; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Pan, JB | 1 |
| Biederman, J; Spencer, T | 1 |
| Hahn, B; Sharples, CG; Shoaib, M; Stolerman, IP; Wonnacott, S | 1 |
| Bisson, WH; Mu, L; Scapozza, L; Schubiger, PA; Westera, G | 1 |
| Bubl, B; Feuerstein, TJ; Hubbe, U; Huethe, F; Jackisch, R; Löffler, M; McIntosh, JM | 1 |
| Decker, MW; Wilens, TE | 1 |
| Barr, JD; Bevins, RA; Murray, JE; Reichel, CM | 1 |
| Gould, TJ; Kenney, JW; Wilkinson, DS | 1 |
| Clementi, F; Dallanoce, C; De Amici, M; De Micheli, C; Gotti, C; Lo Presti, L; Magrone, P; Matera, C; Riganti, L | 1 |
| Franke, AG; Huss, M; Konrad, A; Lieb, K | 1 |
| Guo, L; Guo, T; Liu, K; Yang, C | 1 |
| Geyer, MA; Meves, JM; Young, JW | 1 |
| Araki, H; Hidaka, N; Kato, Y; Suemaru, K | 1 |
| Al-Onaizi, MA; Kolisnyk, B; Prado, MA; Prado, VF | 1 |
| Araki, H; Kiyoi, T; Suemaru, K; Takechi, K; Tanaka, A | 1 |
| Bailey, CD; Chung, BY; Cloke, JM; De Lisio, S; Kim, JC; Nguyen, R; Wasserman, DI; Winters, BD | 1 |
| Calina, D; Martins, N; Peron, G; Rapposelli, S; Salehi, B; Sestito, S; Sharifi-Rad, J; Sharifi-Rad, M; Sharopov, F | 1 |
| Takechi, K | 1 |
6 review(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and isoxazoles
| Article | Year |
|---|---|
Cholinergic channel activators: novel opportunities for the treatment of CNS disorders.
Topics: Animals; Anti-Anxiety Agents; Benzylidene Compounds; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Diseases; Cholinergic Antagonists; Humans; Ion Channels; Isoxazoles; Nicotinic Agonists; Parasympathetic Nervous System; Pyridines; Pyrrolidines; Receptors, Cholinergic | 1995 |
Present and future pharmacotherapeutic options for adult attention deficit/hyperactivity disorder.
Topics: Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Donepezil; Dopamine Plasma Membrane Transport Proteins; Humans; Indans; Isoxazoles; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Piperidines; Pyrrolidines | 2001 |
Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognition.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Cognition; Humans; Isoxazoles; Nicotinic Agonists; Pyridines; Pyrrolidines; Receptors, Nicotinic; Synaptic Transmission | 2007 |
[Stimulant and non-stimulant medication in current and future therapy for ADHD].
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Amphetamines; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Central Nervous System Stimulants; Child; Dextroamphetamine; Fatty Acids, Omega-3; Guanfacine; Histamine Agonists; Humans; Isoxazoles; Lisdexamfetamine Dimesylate; Memantine; Methylphenidate; Modafinil; Off-Label Use; Propylamines; Pyridines; Pyrrolidines; Receptors, AMPA | 2012 |
Epibatidine: A Promising Natural Alkaloid in Health.
Topics: Alkaloids; Analgesics; Attention Deficit Disorder with Hyperactivity; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme System; Humans; Isoxazoles; Neurodegenerative Diseases; Pyridines; Pyrrolidines; Quantum Theory; Receptors, Nicotinic | 2018 |
[Neurobehavioral Comorbidities in Pentylenetetrazol-kindled Mice and Role of the α4β2 Nicotinic Acetylcholine Receptor].
Topics: Animals; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Regulation; Epilepsy; Isoxazoles; Kindling, Neurologic; Membrane Proteins; Mental Disorders; Mice; Nerve Tissue Proteins; Pentylenetetrazole; Piriform Cortex; Psychomotor Performance; Pyrrolidines; Quality of Life; Receptors, Nicotinic; Seizures; Social Behavior | 2019 |
2 trial(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and isoxazoles
| Article | Year |
|---|---|
Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydrocortisone; Isoxazoles; Learning; Male; Memory; Middle Aged; Nicotinic Agonists; Prolactin; Psychomotor Performance; Pyrrolidines | 1999 |
A pilot controlled clinical trial of ABT-418, a cholinergic agonist, in the treatment of adults with attention deficit hyperactivity disorder.
Topics: Administration, Cutaneous; Adult; Age Factors; Anti-Anxiety Agents; Attention Deficit Disorder with Hyperactivity; Cholinergic Agonists; Cross-Over Studies; Dizziness; Double-Blind Method; Female; Humans; Isoxazoles; Male; Nausea; Pilot Projects; Pyrrolidines; Treatment Outcome | 1999 |
41 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and isoxazoles
| Article | Year |
|---|---|
ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Electrophysiology; Isoxazoles; Male; Mecamylamine; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Time Factors; Ventral Tegmental Area | 1995 |
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Cognition; Corpus Striatum; Dopamine; Ion Channels; Isoxazoles; Kinetics; Male; Mice; Nicotine; Parasympathomimetics; PC12 Cells; Pyrrolidines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Nicotinic; Rubidium; Rubidium Radioisotopes; Tritium | 1994 |
Human alpha 7 nicotinic acetylcholine receptor responses to novel ligands.
Topics: Anti-Anxiety Agents; Barium; Benzylidene Compounds; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chloride Channels; Dose-Response Relationship, Drug; Humans; Isoxazoles; Ligands; Membrane Potentials; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Pyridines; Pyrrolidines; Receptors, Nicotinic; RNA, Messenger | 1995 |
Effects of nicotinic acetylcholine receptor ligands on behavioral vigilance in rats.
Topics: Animals; Anti-Anxiety Agents; Arousal; Attention; Behavior, Animal; Isoxazoles; Ligands; Lobeline; Mecamylamine; Nicotine; Pyrrolidines; Rats; Receptors, Nicotinic; Time Factors | 1995 |
Characterization of [3H]ABT-418: a novel cholinergic channel ligand.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Brain; In Vitro Techniques; Isoxazoles; Male; Pyrrolidines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tritium | 1995 |
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.
Topics: Alzheimer Disease; Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Behavior, Animal; Body Temperature; Brain; Cerebrovascular Circulation; Cognition; Electroencephalography; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicotine; Nociceptors; Pyrrolidines; Rats; Rats, Wistar; Receptors, Cholinergic; Seizures; Vomiting | 1994 |
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; Maze Learning; Mecamylamine; Mice; Nicotine; Pyrrolidines; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1994 |
Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats.
Topics: Animals; Anti-Anxiety Agents; Discrimination Learning; Hippocampus; Isoxazoles; Male; Maze Learning; Memory; Parasympathetic Nervous System; Pyrrolidines; Rats; Rats, Wistar; Receptors, Nicotinic; Septum Pellucidum; Space Perception | 1994 |
Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: a novel cholinergic channel activator for memory enhancement.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response Relationship, Drug; Isoxazoles; Learning; Macaca mulatta; Male; Memory; Nicotine; Pyrrolidines; Receptors, Nicotinic; Task Performance and Analysis; Time Factors | 1995 |
Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties.
Topics: Alzheimer Disease; Animals; Anti-Anxiety Agents; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Isoxazoles; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats | 1995 |
Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Discrimination, Psychological; Dose-Response Relationship, Drug; Isoxazoles; Locomotion; Male; Mice; Mice, Inbred ICR; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.
Topics: Animals; Anti-Anxiety Agents; Dogs; Female; Humans; In Vitro Techniques; Isoxazoles; Liver; Macaca fascicularis; Male; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Pan troglodytes; Pyrrolidines; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism | 1995 |
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection | 1995 |
In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Humans; Isoxazoles; Neuroprotective Agents; Nicotinic Agonists; Nicotinic Antagonists; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1996 |
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.
Topics: Administration, Oral; Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Biological Availability; Bungarotoxins; Cell Line; Cognition; Dogs; Haplorhini; Humans; Hypothermia; Isoxazoles; Ligands; Maze Learning; Mice; Molecular Structure; Psychomotor Performance; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Rubidium; Structure-Activity Relationship | 1997 |
Activation and inhibition of rat neuronal nicotinic receptors by ABT-418.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Electrophysiology; Isoxazoles; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; RNA, Messenger; Xenopus | 1997 |
Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Ganglia; Isoxazoles; Kinetics; Male; Mice; Nicotine; Nicotinic Agonists; Nociceptors; PC12 Cells; Pyrrolidines; Rats; Receptors, Nicotinic; Tritium | 1997 |
An attempt to visualize baboon brain nicotinic receptors with N-[11C]ABT-418 and N-[11C]methyl-cytisine.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Carbon Radioisotopes; Cerebral Cortex; Isoxazoles; Kinetics; Papio; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Tomography, Emission-Computed | 1997 |
Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Dopamine; Isoxazoles; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyrrolidines; Quinolizines; Serotonin; Tacrine | 1997 |
Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418.
Topics: Administration, Cutaneous; Aging; Anti-Anxiety Agents; Female; Humans; Injections, Intramuscular; Isoxazoles; Male; Mental Recall; Pyrrolidines; Time Factors | 1997 |
Normalizing effects of nicotine and a novel nicotinic agonist on hippocampal auditory gating in two animal models.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Conditioning, Psychological; Evoked Potentials, Auditory; Female; Hippocampus; Isoxazoles; Male; Mice; Mice, Inbred DBA; Microelectrodes; Nicotine; Nicotinic Agonists; Pyrrolidines; Rats; Rats, Sprague-Dawley | 1997 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys.
Topics: Animals; Anti-Anxiety Agents; Attention; Cholinergic Agents; Dose-Response Relationship, Drug; Female; Isoxazoles; Macaca mulatta; Macaca nemestrina; Male; Mental Recall; Nicotine; Nicotinic Agonists; Photic Stimulation; Pyridines; Pyrrolidines; Receptors, Nicotinic | 1998 |
In vitro evaluation of 11C-labeled (S)-nicotine, (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, and (R,S)-1-methyl-2-(3-pyridyl)azetidine as nicotinic receptor ligands for positron emission tomography studies.
Topics: Animals; Azetidines; Binding Sites; Brain; Carbon Radioisotopes; Isoxazoles; Ligands; Male; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tomography, Emission-Computed | 1998 |
Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats.
Topics: Animals; Attention; Behavior, Animal; Central Nervous System Stimulants; Isoxazoles; Male; Methylphenidate; Nootropic Agents; Prosencephalon; Pyrrolidines; Rats; Rats, Inbred F344; Receptors, Nicotinic | 1999 |
In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(-)[11C]nicotine in rhesus monkeys.
Topics: Animals; Azetidines; Brain; Carbon Radioisotopes; Cerebellum; Isoxazoles; Macaca mulatta; Nicotine; Organ Specificity; Pyrrolidines; Radiopharmaceuticals; Temporal Lobe; Thalamus; Tomography, Emission-Computed | 1999 |
Health news. The sleeper syndrome.
Topics: Alzheimer Disease; Cacao; Humans; Hygiene; Isoxazoles; Margarine; Nicotine; Parkinson Disease; Pyrrolidines; Superoxides | 2001 |
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Topics: Animals; Anti-Anxiety Agents; Arousal; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Central Nervous System Stimulants; Cognition Disorders; Disease Models, Animal; Histamine Antagonists; Imidazoles; Impulsive Behavior; Isoxazoles; Ligands; Male; Methylphenidate; Motor Activity; Nicotinic Agonists; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Histamine H3 | 2002 |
Non-stimulant treatment for Attention-Deficit/Hyperactivity Disorder.
Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Central Nervous System Agents; Child; Cholinesterase Inhibitors; Clinical Trials as Topic; Dopamine Agents; Humans; Isoxazoles; Nootropic Agents; Norepinephrine; Pyrrolidines; Treatment Outcome | 2002 |
Attentional effects of nicotinic agonists in rats.
Topics: Animals; Arecoline; Attention; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Line; In Vitro Techniques; Isoxazoles; Male; Nicotinic Agonists; Photic Stimulation; Pyridines; Pyrrolidines; Radioligand Assay; Rats; Spiro Compounds | 2003 |
Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking.
Topics: Acetylcholine; Animals; Azetidines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Crystallography, X-Ray; Hydrogen Bonding; In Vitro Techniques; Isoxazoles; Ligands; Mice; Models, Molecular; Nerve Tissue Proteins; Oocytes; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Snails; Stereoisomerism; Thermodynamics; Xenopus | 2005 |
Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adolescent; Adult; Aged; Alkaloids; Analysis of Variance; Animals; Autoreceptors; Azocines; Calcium; Child; Child, Preschool; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Feedback; Female; Fluvoxamine; Humans; In Vitro Techniques; Isoxazoles; Male; Maprotiline; Mice; Middle Aged; Neocortex; Nicotine; Nicotinic Antagonists; Potassium; Pyrrolidines; Quinolizines; Rats; Receptors, Nicotinic; Sulpiride; Time Factors; Tritium | 2006 |
Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.
Topics: Animals; Benzazepines; Conditioning, Classical; Discrimination, Psychological; Extinction, Psychological; Generalization, Psychological; Isoxazoles; Ligands; Male; Nicotine; Nicotinic Agonists; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Varenicline | 2010 |
The enhancement of contextual fear conditioning by ABT-418.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Biophysics; Conditioning, Classical; Electroshock; Fear; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pyrrolidines; Statistics, Nonparametric; Vocalization, Animal | 2010 |
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.
Topics: Crystallography, X-Ray; Isoxazoles; Models, Molecular; Molecular Conformation; Neurons; Pyrrolidines; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2010 |
A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease Models, Animal; Immunohistochemistry; Isoxazoles; Male; Maze Learning; Memory; Methylphenidate; Nicotinic Agonists; Pyrrolidines; Rats; Rats, Inbred SHR; Receptors, Nicotinic | 2012 |
Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Choice Behavior; Cholinergic Antagonists; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Psychomotor Performance; Pyrrolidines; Receptors, Nicotinic; Scopolamine | 2013 |
Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats.
Topics: Animals; Electric Stimulation; Electroshock; Isoxazoles; Male; Memory Disorders; Memory, Short-Term; Pyrrolidines; Rats; Rats, Wistar; Receptors, Nicotinic; Recurrence; Seizures | 2013 |
α7 nicotinic ACh receptor-deficient mice exhibit sustained attention impairments that are reversed by β2 nicotinic ACh receptor activation.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Eating; Isoxazoles; Male; Mice, Knockout; Nicotinic Agonists; Pyrrolidines; Receptors, Nicotinic | 2015 |
The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Convulsants; Disease Models, Animal; Isoxazoles; Kindling, Neurologic; Male; Mice, Inbred ICR; Motor Activity; Nicotinic Agonists; Pentylenetetrazole; Psychomotor Performance; Pyrrolidines; Receptors, Nicotinic; Rotarod Performance Test; Seizures; Social Behavior | 2016 |
A Novel Multisensory Integration Task Reveals Robust Deficits in Rodent Models of Schizophrenia: Converging Evidence for Remediation via Nicotinic Receptor Stimulation of Inhibitory Transmission in the Prefrontal Cortex.
Topics: Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Ketamine; Male; Mice; Mice, Inbred C57BL; Nicotinic Agonists; Prefrontal Cortex; Psychomotor Performance; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Nicotinic; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2016 |