3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with epibatidine in 12 studies
| Studies (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Trials (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Recent Studies (post-2010) (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Studies (epibatidine) | Trials (epibatidine) | Recent Studies (post-2010) (epibatidine) |
|---|---|---|---|---|---|
| 68 | 2 | 18 | 70 | 0 | 13 |
| 68 | 2 | 18 | 593 | 0 | 115 |
| Protein | Taxonomy | 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (IC50) | epibatidine (IC50) |
|---|---|---|---|
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | 0.16 | |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | 0.0011 | |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | 0.43 | |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | 0.031 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | 0.0011 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Begtrup, M; Christensen, B; Ehrbar, U; Hansen, JB; Olesen, PH; Pettersson, I; Rimvall, K; Tønder, JE | 1 |
| Bisson, WH; Mu, L; Scapozza, L; Schubiger, PA; Westera, G | 1 |
| Clementi, F; Dallanoce, C; De Amici, M; Gotti, C; Magrone, P; Matera, C; Pucci, L; Rizzi, L | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Anderson, DJ; Arneric, SP; Bannon, AW; Briggs, CA; Brioni, JD; Decker, MW; Donnelly-Roberts, D; Holladay, MW; Sullivan, JP; Williams, M | 1 |
| Briggs, CA; McKenna, DG; Piattoni-Kaplan, M | 1 |
| Nordberg, A; Warpman, U | 1 |
| Meyer, EM; Moulton, BA; Papke, RL; Poirier, A; Thinschmidt, JS | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Manelli, AM; Puttfarcken, PS | 1 |
| Hahn, B; Sharples, CG; Shoaib, M; Stolerman, IP; Wonnacott, S | 1 |
| Calina, D; Martins, N; Peron, G; Rapposelli, S; Salehi, B; Sestito, S; Sharifi-Rad, J; Sharifi-Rad, M; Sharopov, F | 1 |
4 review(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and epibatidine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
Cholinergic channel activators: novel opportunities for the treatment of CNS disorders.
Topics: Animals; Anti-Anxiety Agents; Benzylidene Compounds; Bridged Bicyclo Compounds, Heterocyclic; Central Nervous System Diseases; Cholinergic Antagonists; Humans; Ion Channels; Isoxazoles; Nicotinic Agonists; Parasympathetic Nervous System; Pyridines; Pyrrolidines; Receptors, Cholinergic | 1995 |
Epibatidine: A Promising Natural Alkaloid in Health.
Topics: Alkaloids; Analgesics; Attention Deficit Disorder with Hyperactivity; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme System; Humans; Isoxazoles; Neurodegenerative Diseases; Pyridines; Pyrrolidines; Quantum Theory; Receptors, Nicotinic | 2018 |
8 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and epibatidine
| Article | Year |
|---|---|
Improving the nicotinic pharmacophore with a series of (Isoxazole)methylene-1-azacyclic compounds: synthesis, structure-activity relationship, and molecular modeling.
Topics: Animals; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Hydrogen Bonding; Isoxazoles; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Nicotine; Nitrogen; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Static Electricity; Structure-Activity Relationship; Thermodynamics | 1999 |
Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking.
Topics: Acetylcholine; Animals; Azetidines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Crystallography, X-Ray; Hydrogen Bonding; In Vitro Techniques; Isoxazoles; Ligands; Mice; Models, Molecular; Nerve Tissue Proteins; Oocytes; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Snails; Stereoisomerism; Thermodynamics; Xenopus | 2005 |
Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.
Topics: Animals; Binding, Competitive; Catalysis; Cerebral Cortex; Chemistry, Pharmaceutical; Drug Design; Isoxazoles; Kinetics; Ligands; Models, Chemical; Neurons; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Temperature | 2008 |
Human alpha 7 nicotinic acetylcholine receptor responses to novel ligands.
Topics: Anti-Anxiety Agents; Barium; Benzylidene Compounds; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Chloride Channels; Dose-Response Relationship, Drug; Humans; Isoxazoles; Ligands; Membrane Potentials; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Pyridines; Pyrrolidines; Receptors, Nicotinic; RNA, Messenger | 1995 |
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection | 1995 |
Activation and inhibition of rat neuronal nicotinic receptors by ABT-418.
Topics: Acetylcholine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Electrophysiology; Isoxazoles; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; RNA, Messenger; Xenopus | 1997 |
Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytosine; Dimethylphenylpiperazinium Iodide; Ganglia, Spinal; Hybrid Cells; Isoxazoles; Mice; Neuroblastoma; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Rubidium; Substance P; Synaptic Transmission | 1997 |
Attentional effects of nicotinic agonists in rats.
Topics: Animals; Arecoline; Attention; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Line; In Vitro Techniques; Isoxazoles; Male; Nicotinic Agonists; Photic Stimulation; Pyridines; Pyrrolidines; Radioligand Assay; Rats; Spiro Compounds | 2003 |