3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with cytisine in 8 studies
| Studies (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Trials (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Recent Studies (post-2010) (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Studies (cytisine) | Trials (cytisine) | Recent Studies (post-2010) (cytisine) |
|---|---|---|---|---|---|
| 68 | 2 | 18 | 519 | 19 | 178 |
| Protein | Taxonomy | 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (IC50) | cytisine (IC50) |
|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.0692 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.0692 | |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | 0.05 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | 0.05 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Curtis, MA; Lin, SX; Sperry, J | 1 |
| Adams, P; Anderson, DJ; Arneric, SP; Briggs, CA; Cadman, ED; Donnelly-Roberts, D; Garvey, DS; Hughes, ML; Raszkiewicz, JL; Sullivan, JP | 1 |
| Anderson, DJ; Arneric, SP; Campbell, JE; Pauly, JR; Raszkiewicz, JL; Rotert, G; Surber, B; Thomas, SB; Wasicak, J; Williams, M | 1 |
| Nordberg, A; Warpman, U | 1 |
| Anderson, DJ; Arneric, SP; Brioni, JD; Buccafusco, JJ; Buckley, MJ; Decker, MW; Donnelly-Roberts, DL; Garvey, DS; Gunn, DE; Holladay, MW; Lin, NH; Marsh, KG; Prendergast, MA; Rodrigues, AD; Ryther, KB; Sullivan, JP; Williams, M | 1 |
| Imoto, M; Ohno, T; Saito, K; Tani, Y; Tsuneyoshi, A | 1 |
| Bubl, B; Feuerstein, TJ; Hubbe, U; Huethe, F; Jackisch, R; Löffler, M; McIntosh, JM | 1 |
2 review(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and cytisine
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
Pyridine alkaloids with activity in the central nervous system.
Topics: Alkaloids; Amphibians; Animals; Bacteria; Central Nervous System Diseases; Fungi; Nicotine; Plants; Pyridines; Receptors, Nicotinic | 2020 |
6 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and cytisine
| Article | Year |
|---|---|
(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Cognition; Corpus Striatum; Dopamine; Ion Channels; Isoxazoles; Kinetics; Male; Mice; Nicotine; Parasympathomimetics; PC12 Cells; Pyrrolidines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Nicotinic; Rubidium; Rubidium Radioisotopes; Tritium | 1994 |
Characterization of [3H]ABT-418: a novel cholinergic channel ligand.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Brain; In Vitro Techniques; Isoxazoles; Male; Pyrrolidines; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tritium | 1995 |
Epibatidine and ABT 418 reveal selective losses of alpha 4 beta 2 nicotinic receptors in Alzheimer brains.
Topics: Aged; Aged, 80 and over; Alkaloids; Alzheimer Disease; Animals; Anti-Anxiety Agents; Azocines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Isoxazoles; Kinetics; Mice; Nicotine; Nicotinic Agonists; Pyridines; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Temporal Lobe; Transfection | 1995 |
Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.
Topics: Administration, Oral; Alkaloids; Animals; Anti-Anxiety Agents; Azocines; Biological Availability; Bungarotoxins; Cell Line; Cognition; Dogs; Haplorhini; Humans; Hypothermia; Isoxazoles; Ligands; Maze Learning; Mice; Molecular Structure; Psychomotor Performance; Pyrrolidines; Quinolizines; Receptors, Nicotinic; Rubidium; Structure-Activity Relationship | 1997 |
Nicotinic acetylcholine receptor (nACh-R) agonist-induced changes in brain monoamine turnover in mice.
Topics: Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Dopamine; Isoxazoles; Male; Mecamylamine; Mice; Mice, Inbred Strains; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pyrrolidines; Quinolizines; Serotonin; Tacrine | 1997 |
Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adolescent; Adult; Aged; Alkaloids; Analysis of Variance; Animals; Autoreceptors; Azocines; Calcium; Child; Child, Preschool; Domperidone; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Feedback; Female; Fluvoxamine; Humans; In Vitro Techniques; Isoxazoles; Male; Maprotiline; Mice; Middle Aged; Neocortex; Nicotine; Nicotinic Antagonists; Potassium; Pyrrolidines; Quinolizines; Rats; Receptors, Nicotinic; Sulpiride; Time Factors; Tritium | 2006 |