3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole has been researched along with a 85380 in 3 studies
| Studies (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Trials (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Recent Studies (post-2010) (3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole) | Studies (a 85380) | Trials (a 85380) | Recent Studies (post-2010) (a 85380) |
|---|---|---|---|---|---|
| 68 | 2 | 18 | 101 | 1 | 22 |
| Protein | Taxonomy | 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (IC50) | a 85380 (IC50) |
|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | 0.0015 | |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | 0.0015 | |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | 0.0015 | |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | 0.0015 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dart, MJ; Holladay, MW; Lynch, JK | 1 |
| Brunner, D; Caldarone, B; Eaton, JB; Fedolak, A; Hanania, T; Kozikowski, AP; Lukas, RJ; Tückmantel, W; Yu, LF | 1 |
| Bisson, WH; Mu, L; Scapozza, L; Schubiger, PA; Westera, G | 1 |
1 review(s) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and a 85380
| Article | Year |
|---|---|
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1997 |
2 other study(ies) available for 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole and a 85380
| Article | Year |
|---|---|
Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
Topics: Animals; Antidepressive Agents; Blood Proteins; Cytochrome P-450 Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Nicotinic Agonists; Protein Binding; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2012 |
Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking.
Topics: Acetylcholine; Animals; Azetidines; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Crystallography, X-Ray; Hydrogen Bonding; In Vitro Techniques; Isoxazoles; Ligands; Mice; Models, Molecular; Nerve Tissue Proteins; Oocytes; Pyridines; Pyrrolidines; Rats; Receptors, Nicotinic; Snails; Stereoisomerism; Thermodynamics; Xenopus | 2005 |