Page last updated: 2024-09-03

3-methyl-4',6-dihydroxy-3',5'-dibromoflavone and triiodothyronine

3-methyl-4',6-dihydroxy-3',5'-dibromoflavone has been researched along with triiodothyronine in 8 studies

Compound Research Comparison

Studies
(3-methyl-4',6-dihydroxy-3',5'-dibromoflavone)
Trials
(3-methyl-4',6-dihydroxy-3',5'-dibromoflavone)
Recent Studies (post-2010)
(3-methyl-4',6-dihydroxy-3',5'-dibromoflavone)
Studies
(triiodothyronine)
Trials
(triiodothyronine)
Recent Studies (post-2010) (triiodothyronine)
130026,2478613,473

Protein Interaction Comparison

ProteinTaxonomy3-methyl-4',6-dihydroxy-3',5'-dibromoflavone (IC50)triiodothyronine (IC50)
Thyroid hormone receptor alphaHomo sapiens (human)0.0006
Thyroid hormone receptor betaHomo sapiens (human)0.0006
Proliferating cell nuclear antigenHomo sapiens (human)3.6
Thyroid hormone receptor betaRattus norvegicus (Norway rat)0.0031
Adenosine receptor A1Homo sapiens (human)0.4109

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Köhrle, J; Schröder-van der Elst, JP; van der Heide, D1
Abend, SL; Alex, S; Braverman, LE; Fang, SL; Leonard, JL1
Hesch, RD; Irmscher, K; Köhrle, J; Spanka, M2
Barlow, JW; Curtis, AJ; Loidl, NM; Raggatt, LE; Stockigt, JR; Topliss, DJ1
Benson, MD; Cody, V; Liepnieks, JJ; Moses, AC; Murrell, JR; Rosen, HN1
Kennedy, JA; Lim, CF; Loidl, NM; Stockigt, JR; Topliss, DJ1
Asunción, M; Calvo, R; Escobar del Rey, F; Morreale de Escobar, GM; Obregón, MJ; Pedraza, P1

Other Studies

8 other study(ies) available for 3-methyl-4',6-dihydroxy-3',5'-dibromoflavone and triiodothyronine

ArticleYear
In vivo effects of flavonoid EMD 21388 on thyroid hormone secretion and metabolism in rats.
    The American journal of physiology, 1991, Volume: 261, Issue:2 Pt 1

    Topics: Adipose Tissue, Brown; Animals; Brain; Chromatography, High Pressure Liquid; Flavonoids; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroxine; Tissue Distribution; Triiodothyronine; Triiodothyronine, Reverse

1991
Rapid alteration in circulating free thyroxine modulates pituitary type II 5' deiodinase and basal thyrotropin secretion in the rat.
    The Journal of clinical investigation, 1991, Volume: 88, Issue:3

    Topics: Animals; Flavonoids; Iodide Peroxidase; Male; Pituitary Gland; Prealbumin; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Thyrotropin; Thyroxine; Triiodothyronine

1991
5'-Deiodination in rat hepatocytes: effects of specific flavonoid inhibitors.
    Endocrinology, 1990, Volume: 126, Issue:3

    Topics: Animals; Benzofurans; Cell Survival; Chemical Phenomena; Chemistry; Flavonoids; Iodide Peroxidase; Iodine; Liver; Rats; Structure-Activity Relationship; Thyroxine; Triiodothyronine

1990
Flavonoid effects on transport, metabolism and action of thyroid hormones.
    Progress in clinical and biological research, 1988, Volume: 280

    Topics: Animals; Binding Sites; Binding, Competitive; Flavonoids; In Vitro Techniques; Iodide Peroxidase; Liver; Male; Microsomes, Liver; Models, Biological; Models, Molecular; Rats; Structure-Activity Relationship; Thyroid Hormones; Thyroidectomy; Thyroxine; Thyroxine-Binding Proteins; Triiodothyronine

1988
Drug competition for intracellular triiodothyronine-binding sites.
    European journal of endocrinology, 1994, Volume: 130, Issue:4

    Topics: Amiodarone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Binding, Competitive; Carcinoma, Hepatocellular; Fatty Acids, Nonesterified; Flavonoids; Furosemide; Humans; Iodide Peroxidase; Liver; Liver Neoplasms; Macaca fascicularis; Sex Hormone-Binding Globulin; Sulfobromophthalein; Triiodothyronine; Tumor Cells, Cultured

1994
Threonine for alanine substitution at position 109 of transthyretin differentially alters human transthyretin's affinity for iodothyronines.
    Endocrinology, 1994, Volume: 134, Issue:1

    Topics: Alanine; Amino Acid Sequence; Binding, Competitive; Escherichia coli; Flavonoids; Humans; Point Mutation; Prealbumin; Recombinant Proteins; Stereoisomerism; Threonine; Thyroxine; Triiodothyronine

1994
Drug effects on triiodothyronine uptake by rat anterior pituitary cells in vitro.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1996, Volume: 104, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cells, Cultured; Diuretics; Enzyme Inhibitors; Flavonoids; Iodide Peroxidase; Iodine Radioisotopes; Male; Phenytoin; Pituitary Gland, Anterior; Rats; Rats, Wistar; Serum Albumin, Bovine; Thyroxine; Triiodothyronine

1996
Displacement of T4 from transthyretin by the synthetic flavonoid EMD 21388 results in increased production of T3 from T4 in rat dams and fetuses.
    Endocrinology, 1996, Volume: 137, Issue:11

    Topics: Adipose Tissue, Brown; Animals; Binding, Competitive; Brain; Enzyme Inhibitors; Female; Fetus; Flavonoids; Infusions, Intravenous; Iodide Peroxidase; Liver; Lung; Mammary Glands, Animal; Maternal-Fetal Exchange; Methimazole; Myocardium; Placenta; Prealbumin; Pregnancy; Pregnancy, Animal; Radioimmunoassay; Rats; Rats, Wistar; Thyroid Gland; Thyroxine; Triiodothyronine

1996