Compounds > 3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid
Page last updated: 2024-09-03

3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid and indomethacin

3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid has been researched along with indomethacin in 2 studies

Compound Research Comparison

Studies
(3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid)		Trials
(3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid)		Recent Studies (post-2010)
(3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
361129,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomy3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cóte, D; Ksander, G; Levens, NR1
Ksander, GM; Levens, NR; Mullane, KM; Zimmerman, MB1

Other Studies

2 other study(ies) available for 3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid and indomethacin

ArticleYear
Inhibition of thromboxane synthetase potentiates the antihypertensive action of an angiotensin-converting enzyme inhibitor by a prostaglandin-dependent but kinin-independent mechanism.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Drug Synergism; Indomethacin; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Species Specificity; Thromboxane-A Synthase; Verapamil

1991
Thromboxane synthase inhibition enhances action of converting enzyme inhibitors.
    Hypertension (Dallas, Tex. : 1979), 1989, Volume: 13, Issue:1

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Drug Synergism; Hydralazine; Indomethacin; Kidney; Phenylacetates; Pyridines; Rats; Rats, Inbred SHR; Sulfonamides; Thromboxane-A Synthase

1989