3-methoxytyrosine has been researched along with tyrosine in 169 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (18.93) | 18.7374 |
| 1990's | 74 (43.79) | 18.2507 |
| 2000's | 35 (20.71) | 29.6817 |
| 2010's | 21 (12.43) | 24.3611 |
| 2020's | 7 (4.14) | 2.80 |
| Authors | Studies |
|---|---|
| Clayton, PT; Hyland, K | 2 |
| Hasegawa, S; Konagaya, Y; Maruyama, W; Mokuno, K; Nakahara, D; Naoi, M; Takahashi, A; Watanabe, H | 1 |
| Lindén, IB; Nissinen, E; Pohto, P; Schultz, E | 1 |
| Bjurling, P; Gillberg, PG; Långström, B; Miwa, S; Odano, I; Watanabe, Y; Yumoto, N | 1 |
| Cedarbaum, JM; Diksic, M; Evans, A; Gjedde, A; Guttman, M; Léger, G; Reches, A; Woodward, W | 1 |
| Kaakkola, S; Männistö, PT; Tuomainen, P; Wurtman, RJ | 1 |
| Jenner, P; Marsden, CD; Rose, S | 2 |
| Adam, MJ; Chan, GL; Hewitt, KA; Pate, BD; Ruth, TJ; Schofield, P | 1 |
| Armando, I; Goldstein, DS; Grossman, E; Hoffman, A | 1 |
| Abe, T; Kikuchi, T; Nozaki, Y; Takahashi, S; Tohgi, H | 2 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S | 3 |
| Deleu, D; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Wikberg, T | 1 |
| Adams, HR; Aigner, TG; Carson, R; Cohen, RM; Doudet, DJ; Finn, RT; McLellan, CA; Miyake, H | 1 |
| Cedarbaum, JM; Guttman, M; Leger, G | 1 |
| Colzi, A; Da Prada, M; Zürcher, G | 1 |
| August, TF; Bayne, WF; Eisenhandler, R; Musson, DG; Titus, DC; Yeh, KC | 1 |
| Da Prada, M; Zürcher, G | 1 |
| De Herdt, P; Maitre, L; Waldmeier, PC | 1 |
| Antonin, KH; Bieck, PR; Nilsson, E | 1 |
| Fujitake, J; Kuno, S; Mizuta, E | 1 |
| Cedarbaum, JM; Guttman, M; Léger, G; Reches, A | 1 |
| Bassant, MH; Godefroy, F; Lamour, Y; Sarhan, H; Weil-Fugazza, J | 1 |
| Hyland, K; Surtees, R | 1 |
| Banwart, B; Jones, JD; Miller, TD; Tyce, GM | 1 |
| Cedarbaum, JM; Kutt, H; McDowell, FH | 2 |
| August, TF; Bush, DF; Lasseter, KC; Musson, DG; Schwartz, S; Smith, ME; Titus, DC; Yeh, KC | 1 |
| Berchou, RC; Galloway, MP; Kareti, D; Kesaree, N; LeWitt, PA; Nelson, MV; Schlick, P | 1 |
| Luquin, MR; Obeso, JA; Vaamonde, J | 1 |
| Baruzzi, A; Contin, M; Martinelli, P; Procaccianti, G; Riva, R | 1 |
| Boomsma, F; Hovestadt, A; Man in't Veld, AJ; Meerwaldt, JD; Schalekamp, MA | 1 |
| Hisaka, A; Ihara, M; Sawasaki, Y; Takehana, H; Tomimoto, K; Tsuchiya, Y; Yano, M | 1 |
| Cohen, Y; el Gemayel, G; Jacquot, C; Prioux-Guyonneau, M; Trouvin, JH | 1 |
| Da Prada, M; Haefely, WE; Kettler, R; Schaffner, R; Zürcher, G | 1 |
| Cramers, CA; de Jong, AP; Haan, E; Kok, RM; Wadman, SK | 1 |
| Dousa, MK; Tyce, GM | 1 |
| Kaakkola, S; Lindén, IB; Männistö, PT; Nissinen, E; Pohto, P; Schultz, E | 1 |
| Allen, JG; Bird, H; Malcolm, SL; Marion, MH; Marsden, CD; O'Leary, CG; Quinn, NP | 1 |
| Allen, JG; Hardie, RJ; Lees, AJ; Malcolm, SL; Stern, GM | 1 |
| Chase, TN; Fabbrini, G; Juncos, JL; Mouradian, MM; Serrati, C | 1 |
| Gancher, ST; Merrick, D; Nutt, JG; Woodward, WR | 1 |
| Hirose, S; Ishimitsu, T | 2 |
| Bohner, B; Ensor, CR; McCarthy, DA; McLean, JR; Potoczak, D | 1 |
| Huot, S; Palfreyman, MG; Vitali, P; Wagner, J; Zraika, M | 1 |
| Ali, FM; Barnes, DA; Black, ML; Camp, VM; Faraj, BA; Lawson, DH; Nixon, DW; Richmond, A; Tindall, GT | 1 |
| Aguado, EG; de Yebenes, JG; Mena, MA | 1 |
| Fellman, JH; Nutt, JG | 1 |
| Beers, MF; Hurtig, H; Melvin, G; Scarpa, A; Stern, M | 1 |
| Asahara, K; Hirose, S; Imaizumi, M; Ishimitsu, T | 1 |
| Aguado, EG; Bazán, E; de Yébenes, JG; Gervas, JJ; Muradás, V | 1 |
| Fahn, S; Prasad, AL | 1 |
| Fahn, S; Reches, A | 1 |
| Fahn, S; Mielke, LR; Reches, A | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K | 1 |
| Kaakkola, S; Kask, A; Männistö, PT; Törnwall, M; Tuomainen, P | 1 |
| Bertrand, A; Weil-Fugazza, J | 1 |
| Abe, T; Saheki, M; Takahashi, S; Tohgi, H; Tsukamoto, Y; Yamazaki, K | 1 |
| Bamberg, H; Böhme, V; Moser, A; Nobbe, F; Scholz, J; Vieregge, P | 1 |
| Aguirre, J; Armando, I; Barontini, M; Nowicki, S | 1 |
| Carey, RJ; Dai, H; Huston, JP; Pinheiro-Carrera, M; Schwarting, RK; Tomaz, C | 1 |
| Buchle, AM; Steulet, AF; Waldmeier, PC | 1 |
| Himori, N; Mishima, K | 1 |
| Aruoma, OI; Dexter, DT; Evans, PJ; Halliwell, B; Jenner, A; Jenner, P; Kaur, H; Lees, AJ; Marsden, DC; Spencer, JP | 1 |
| Acerbi, D; Mariotti, F; Rondelli, I; Ventura, P | 1 |
| Bredberg, E; Lennernäs, H; Paalzow, L | 1 |
| Fernandes, MH; Pinto-do-O, PC; Soares-da-Silva, P | 1 |
| Akaike, N; Himori, N; Kurasawa, M; Mishima, K; Tanaka, Y | 1 |
| Antonin, KH; Bieck, PR; Dostert, P; Farger, G; Nilsson, EB; Schmidt, EK; Strolin Benedetti, M; Waldmeier, PC | 1 |
| Bennett, JP; Schuh, LA | 1 |
| Kaakkola, S; Wurtman, RJ | 1 |
| Baraldo, M; Benetello, P; Furlanut, M; Hassan, E; Zara, G | 1 |
| Carter, JH; Gancher, ST; Hammerstad, JP; Nutt, JG; Woodward, W | 1 |
| Gordin, A; Harjola, VP; Karlsson, M; Keränen, T; Korpela, K; Pentikäinen, PJ; Rita, H; Seppälä, L; Wikberg, T | 1 |
| Cohen, G; DiRocco, A; Merchant, CA; Molinari, S; Moros, D; Mytilineou, C; Yahr, MD | 1 |
| Chang, WY; Webster, RA | 1 |
| Rinne, UK; Ruottinen, HM | 1 |
| Belakhlef, A; Chaly, T; Dahl, R; Dhawan, V; Eidelberg, D; Ishikawa, T; Mandel, F; Margouleff, C; Robeson, W | 1 |
| Joseph, JA; Miller, JW; Selhub, J | 1 |
| Antila, S; Gordin, A; Keränen, T; Koulu, M; Scheinin, M; Sundberg, S; Wikberg, T | 1 |
| Achilli, G; Banting, A; Banting, S; Le Bars, D; Weil-Fugazza, J | 1 |
| Aguirre, J; Armando, I; Arrizurieta, EE; Barontini, M; Ibarra, FR; Nowicki, S | 1 |
| O'Connell, MT; Patsalos, PN; Quinn, NP; Tison, F | 1 |
| Brannan, T; Prikhojan, A; Yahr, MD | 1 |
| Hattori, Y; Kanazawa, I; Kowa, H; Kuno, S; Mizuno, Y; Narabayashi, H; Tohgi, H; Tsukamoto, Y; Yamamoto, M; Yanagisawa, N; Yokochi, M | 1 |
| Crevoisier, C; Dingemanse, J; Kleinbloesem, CH; Wood, ND; Zürcher, G | 1 |
| Baraldo, M; Benetello, P; Fortunato, M; Furlanut, M; Pea, F | 1 |
| Antkiewicz-Michaluk, L; Krygowska-Wajs, A; Romańska, I; Szczudlik, A; Vetulani, J | 1 |
| Blandini, F; Desideri, S; Martignoni, E; Nappi, G; Pacchetti, C; Rivellini, D | 1 |
| Hay, M; Mormède, P | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Kleinbloesem, CH; Lankhaar, G | 1 |
| Jaskowski, P; Kömpf, D; Moser, A; Siebecker, F; Vieregge, P | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Lankhaar, G; Ouwerkerk, M | 1 |
| Beiske, A; Fotteler, B; Jorga, KM; Larsen, JP; Moe, B; Schleimer, M; Schmitt, M | 1 |
| Buchholz, J; Iacono, RP; Kuniyoshi, S; Liu, H; Schoonenberg, T | 1 |
| Furlanut, M; Wu, G | 1 |
| Schoser, BG; Stuerenburg, HJ | 1 |
| Blandini, F; Desideri, S; Godi, L; Mancini, F; Martignoni, E; Nappi, G; Pacchetti, C | 1 |
| Gomes, P; Soares-da-Silva, P | 1 |
| Blandini, F; di Jeso, F; Martignoni, E; Nappi, G; Ricotti, R | 1 |
| Bareiss, M; Blessing, H; Carvey, P; Jankowski, S; Ling, ZD; Schwarz, J; Storch, A | 1 |
| Jackson, M; Jenner, P; Treseder, SA | 1 |
| Parada, A; Serrão, P; Soares-da-Silva, P | 1 |
| Bräutigam, C; Hoffman, GF; Hyland, K; Knust, A; Sharma, RK; Wevers, RA | 1 |
| Jenner, P; Rose, S; Treseder, SA | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Kawano, H; Matsushita, H; Ochi, M; Sakai, H; Takeuchi, Y | 1 |
| Blandini, F; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Samuele, A | 1 |
| Hainzl, D; Loureiro, AI; Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Charlton, CG; Lamango, N; Latinwo, L; Lee, ES; Liu, XX; Zhao, WQ | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| Fowler, B; Kuhn, W; Müller, T; Woitalla, D | 1 |
| Goto, K; Ikemoto, S; Yui, K | 1 |
| Calvi-Gries, F; Crevoisier, C; Nilsen, T; Zerr, P | 1 |
| Schmidt, WJ; Srinivasan, J | 2 |
| Blandini, F; Bono, G; Calandrella, D; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Riboldazzi, G; Samuele, A | 1 |
| Almeida, L; Falcão, A; Loureiro, A; Machado, R; Maia, J; Silveira, P; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Amirkhani, A; Nilsson, S; Nyholm, L; Nyholm, LM; Törnkvist, A | 1 |
| Masuda, N; Nagae, Y; Nakashima, A; Niina, M; Saxer, C | 1 |
| Chiriboga, CA; Clayton, PT; De Vivo, DC; Ford, B; Hinton, V; Hyland, K; Pons, R; Sharma, R | 1 |
| Muhlack, S; Müller, T; Przuntek, H; Twiehaus, S; Welnic, J; Woitalla, D | 1 |
| Charlton, CG; Chen, H; Lee, ES; Soliman, KF | 1 |
| Casapullo, A; D'Auria, MV; D'Orsi, R; Monti, MC; Sepe, V; Zampella, A | 1 |
| Gilbert, DL; Merhar, SL | 1 |
| Carl, JL; Karimi, M; Loftin, S; Perlmutter, JS | 1 |
| Bremen, D; Erdmann, C; Goetze, O; Muhlack, S; Müller, T; Przuntek, H; Woitalla, D | 1 |
| Muhlack, S; Müller, T; Welnic, J | 1 |
| Ander, L; Kolf, K; Muhlack, S; Müller, T; Woitalla, D | 1 |
| Charlton, C; Chen, H; King, J; Lee, ES | 1 |
| Allen, RP; Connor, JR; Earley, CJ; Hyland, K | 1 |
| Almeida, L; Costa, R; Falcão, A; Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, J; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Kuhn, W; Müller, T | 1 |
| Muhlack, S; Müller, T | 2 |
| Almeida, L; Costa, R; Falcão, A; Fernandes-Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, JF; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Hsu, FL; Hsu, KY; Lin, SJ; Uang, YS; Wang, LH; Yang, LM | 1 |
| Area, E; Artuch, R; Cormand, B; Drakaki, K; Garcia-Cazorla, A; Giannakopoulos, A; Kanavakis, E; Orfanou, I; Ormazabal, A; Pons, R; Ribasés, M; Serrano, M; Toma, C; Youroukos, S | 1 |
| Adamiak, U; Bialecka, M; Gawronska-Szklarz, B; Kaldonska, M; Klodowska-Duda, G; Safranow, K; Wyska, E | 1 |
| Geurtz, PB; Lammens, M; Lee, WT; Verbeek, MM; Verrijp, K; Wassenberg, T; Wevers, RA; Willemsen, MA; Wilmer, M | 1 |
| Muhlack, S; Müller, T; Woitalla, D | 1 |
| Blau, N; Dill, P; Jakobs, C; Schneider, J; Tekin, M; Thöny, B; Trachsel, D; Weber, P | 1 |
| Ishihara, A; Kihira, K; Kimura, Y; Matsumoto, M; Miyachi, T; Nakamura, T; Ohtsuki, T; Yamawaki, T | 1 |
| Askmark, H; Johansson, A; Lennernäs, H; Nyholm, D | 1 |
| Hirosawa, T; Kihira, K; Kimura, Y; Onzawa, Y; Shirasuna, M; Taogoshi, T; Uzuhashi, K | 1 |
| Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Chatamra, K; Dutta, S; Johansson, A; Locke, C; Nyholm, D; Odin, P; Othman, AA | 1 |
| Chen, PW; Chien, YH; Hwu, WL; Lee, NC; Wang, PC; Wu, JY | 1 |
| Cardoso, MA; de Carvalho, KA; de Francisco, TM; de Oliveira Vilhena, R; Gasparetto, JC; Guimarães de Francisco, TM; Martins, CA; Pontarolo, R; Ribeiro, RP | 1 |
| Cao, L; Hao, H; Hao, K; Li, F; Liu, H; Qi, Q; Wang, H | 1 |
| Bishnoi, P; Charde, SY; Raut, PP | 1 |
| Chao, MC; Chen, PW; Chien, YH; Chiu, PC; Chu, SY; Hsieh, WS; Hwu, WL; Jong, YJ; Lee, NC; Lin, SP; Tsai, FJ | 1 |
| Asanuma, M; Miyazaki, I | 1 |
| Akiyama, M; Akiyama, T; Hanaoka, Y; Hayashi, Y; Kobayashi, K; Kubota, M; Nakamura, K; Shibata, T; Tsuyusaki, Y; Yoshinaga, H | 1 |
| Herrman, L; Kinkel, M; Muhlack, S; Müller, T | 1 |
| Eisenhofer, G; Huebner, A; Mangelis, A; Peitzsch, M | 1 |
| Berthold, F; Butch, ER; Eisenhofer, G; Furman, WL; Hero, B; Huebner, A; Lovorn, E; Mangelis, A; Peitzsch, M; Santana, VM; Shulkin, BL | 1 |
| Brennenstuhl, H; Feyh, P; Garbade, SF; Gramer, G; Hoffmann, GF; Kohlmüller, D; Kölker, S; Okun, JG; Opladen, T; Syrbe, S | 1 |
| Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T | 1 |
| Anstey, NM; DeRisi, JL; Florence, SM; Granger, DL; Hyland, K; Langelier, C; Lopansri, BK; Mukemba, JP; Mwaikambo, ED; Nakielny, S; Rubach, MP; Simmons, RA; Weinberg, JB; Yeo, TW | 1 |
| Blau, N; Burlina, A; Burlina, AP; Cazzorla, C; Giuliani, A; Gragnaniello, V; Gueraldi, D; Hoffmann, G; Opladen, T; Polo, G | 1 |
| Ho, Y; Hsu, KY; Huang, YJ; Lin, SJ; Tai, L; Uang, YS; Wang, LH | 1 |
| Angeloni, A; Carducci, C; Di Carlo, E; Leuzzi, V; Manti, F; Santagata, S; Sauro, L; Tolve, M | 1 |
2 review(s) available for 3-methoxytyrosine and tyrosine
| Article | Year |
|---|---|
Pharmacokinetics of levodopa.
Topics: Administration, Oral; Age Factors; Amino Acids; Biological Availability; Biological Transport; Biotransformation; Blood-Brain Barrier; Gastric Emptying; Humans; Intestinal Absorption; Kinetics; Levodopa; Methyltyrosines; Time Factors; Tissue Distribution; Tyrosine | 1984 |
Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool; Disease Progression; Dopamine Agonists; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Male; Monoamine Oxidase Inhibitors; Prognosis; Sex Factors; Treatment Outcome; Tyrosine; Vitamin B 6 | 2004 |
30 trial(s) available for 3-methoxytyrosine and tyrosine
| Article | Year |
|---|---|
Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Biological Availability; Carbidopa; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combinations; Fasting; Half-Life; Humans; Intestinal Absorption; Levodopa; Middle Aged; Parkinson Disease; Random Allocation; Reference Values; Tablets; Tyrosine | 1989 |
Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies.
Topics: Aged; Antiparkinson Agents; Carbidopa; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease; Random Allocation; Tyrosine | 1989 |
Clinical significance of the relationship between O-methyldopa levels and levodopa intake.
Topics: Animals; Carbidopa; Corpus Striatum; Delayed-Action Preparations; Drug Combinations; Female; Humans; Levodopa; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
The pharmacokinetics of intravenous and oral levodopa in patients with Parkinson's disease who exhibit on-off fluctuations.
Topics: Absorption; Administration, Oral; Adult; Carboxy-Lyases; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Half-Life; Humans; Infusions, Intravenous; Kinetics; Levodopa; Male; Middle Aged; Parkinson Disease; Random Allocation; Tyrosine | 1986 |
Human transplacental transfer of carbidopa/levodopa.
Topics: Antiparkinson Agents; Carbidopa; Dopamine; Female; Fetus; Homovanillic Acid; Humans; Levodopa; Maternal-Fetal Exchange; Parkinson Disease; Pregnancy; Tyrosine | 1995 |
Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients.
Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine Agents; Double-Blind Method; Enzyme Inhibitors; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 1996 |
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers.
Topics: Adult; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Over Studies; Dopamine; Double-Blind Method; Enzyme Inhibitors; Human Growth Hormone; Humans; Levodopa; Male; Nitriles; Placebos; Prolactin; Tyrosine | 1996 |
Clinical drug monitoring by microdialysis: application to levodopa therapy in Parkinson's disease.
Topics: Antiparkinson Agents; Area Under Curve; Drug Monitoring; Half-Life; Humans; Levodopa; Microdialysis; Parkinson Disease; Tyrosine | 1996 |
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Area Under Curve; Benzophenones; Catechol O-Methyltransferase Inhibitors; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1997 |
Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antiparkinson Agents; Benserazide; Carboxy-Lyases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Levodopa and 3-O-methyldopa in cerebrospinal fluid after levodopa-carbidopa association.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Drug Combinations; Electrochemistry; Female; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Increase in salsolinol level in the cerebrospinal fluid of parkinsonian patients is related to dementia: advantage of a new high-performance liquid chromatography methodology.
Topics: Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dementia; Female; Homovanillic Acid; Humans; Isoquinolines; Levodopa; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Tyrosine | 1997 |
Pharmacokinetic studies with a dual-release formulation of levodopa, a novel principle in the treatment of Parkinson's disease.
Topics: Adolescent; Adult; Antiparkinson Agents; Cross-Over Studies; Delayed-Action Preparations; Female; Food; Humans; Levodopa; Male; Parkinson Disease; Tablets; Tyrosine | 1998 |
Comparative single- and multiple-dose pharmacokinetics of levodopa and 3-O-methyldopa following a new dual-release and a conventional slow-release formulation of levodopa and benserazide in healthy subjects.
Topics: Benserazide; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Humans; Levodopa; Metabolic Clearance Rate; Time Factors; Tyrosine | 1998 |
The effect of tolcapone on the pharmacokinetics of benserazide.
Topics: Aged; Antiparkinson Agents; Benserazide; Benzophenones; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Time Factors; Tolcapone; Tyrosine | 1999 |
Pharmacodynamic modelling of levodopa, 3-O-methyldopa and their effects: an application of the Dixon equation.
Topics: Aged; Drug Interactions; Female; Humans; Levodopa; Male; Models, Statistical; Parkinson Disease; Tyrosine | 1999 |
Peripheral markers of oxidative stress in Parkinson's disease. The role of L-DOPA.
Topics: Antiparkinson Agents; Biomarkers; Blood Platelets; Dopamine; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Levodopa; Linear Models; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Sodium Salicylate; Superoxide Dismutase; Tyrosine | 1999 |
Determination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Hydroxybenzoates; Hydroxyl Radical; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
Effects of food on the pharmacokinetics of levodopa in a dual-release formulation.
Topics: Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Female; Food; Food-Drug Interactions; Half-Life; Humans; Levodopa; Male; Time Factors; Tyrosine | 2003 |
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine | 2003 |
Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Area Under Curve; Benserazide; Biological Availability; Dihydroxyphenylalanine; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors; Tyrosine | 2004 |
Pharmacokinetic behaviour of levodopa and 3-O-methyldopa after repeat administration of levodopa/carbidopa with and without entacapone in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Tyrosine | 2006 |
Acute levodopa administration reduces cortisol release in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Benserazide; Down-Regulation; Enzyme Inhibitors; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Levodopa; Male; Middle Aged; Neural Pathways; Parkinson Disease; Raphe Nuclei; Serotonin; Tyrosine | 2007 |
Comparison of 200 mg retarded release levodopa/carbidopa - with 150 mg levodopa/carbidopa/entacapone application: pharmacokinetics and efficacy in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Carbidopa; Catechols; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 2007 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects.
Topics: Acetophenones; Adult; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Humans; Levodopa; Male; Time Factors; Tyrosine; Young Adult | 2008 |
Homocysteine levels after acute levodopa intake in patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Severity of Illness Index; Statistics as Topic; Time Factors; Tyrosine | 2009 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine; Young Adult | 2009 |
Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.
Topics: Age of Onset; Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Therapy, Combination; Dyskinesias; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Nitrophenols; Parkinson Disease; Severity of Illness Index; Tolcapone; Tyrosine | 2010 |
Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Combinations; Drug Therapy, Combination; Female; Half-Life; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 2011 |
Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechols; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Nitrophenols; Parkinson Disease; Pilot Projects; Self Report; Single-Blind Method; Sweden; Tolcapone; Tyrosine | 2012 |
137 other study(ies) available for 3-methoxytyrosine and tyrosine
| Article | Year |
|---|---|
Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology.
Topics: 5-Hydroxytryptophan; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dopa Decarboxylase; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Levodopa; Liver; Metabolism, Inborn Errors; Reference Values; Tyrosine | 1992 |
The mechanism of perturbation in monoamine metabolism by L-dopa therapy: in vivo and in vitro studies.
Topics: Aged; Amino Acids; Animals; Biogenic Monoamines; Corpus Striatum; Dialysis; Dopamine; Female; Humans; In Vitro Techniques; Kinetics; Levodopa; Male; Middle Aged; Neurons; Parkinson Disease; PC12 Cells; Rats; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1992 |
Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Duodenum; Erythrocytes; Homovanillic Acid; In Vitro Techniques; Liver; Male; Nitriles; Rats; Rats, Wistar; Tyrosine | 1992 |
Assessment of dopamine and its metabolites in the intracellular and extracellular compartments of the rat striatum after peripheral administration of L-[11C]dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Extracellular Space; Homovanillic Acid; Injections, Intravenous; Intracellular Fluid; Kinetics; Levodopa; Male; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
3-O-methyldopa administration does not alter fluorodopa transport into the brain.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Binding, Competitive; Biological Transport; Blood-Brain Barrier; Brain; Carrier Proteins; Dihydroxyphenylalanine; Macaca fascicularis; Male; Tomography, Emission-Computed; Tyrosine | 1992 |
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Corpus Striatum; Depression, Chemical; Dialysis; Dopamine; Homovanillic Acid; Hypothalamus; Injections, Intraperitoneal; Levodopa; Male; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Peripheral pharmacokinetic handling and metabolism of L-dopa in the rat: the effect of route of administration and carbidopa pretreatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Aorta, Thoracic; Carbidopa; Chromatography, High Pressure Liquid; Homovanillic Acid; Injections, Intravenous; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
Aromatic amino acid decarboxylase deficiency in twins.
Topics: Aromatic-L-Amino-Acid Decarboxylases; Bromocriptine; Diseases in Twins; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Male; Norepinephrine; Pyridoxine; Serotonin; Tranylcypromine; Twins, Monozygotic; Tyrosine | 1990 |
Routine determination of [18F]-L-6-fluorodopa and its metabolites in blood plasma is essential for accurate positron emission tomography studies.
Topics: Adsorption; Age Factors; Aluminum Oxide; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Humans; Tomography, Emission-Computed; Tyrosine | 1992 |
Method for measuring endogenous 3-O-methyldopa in urine and plasma.
Topics: Animals; Chromatography, Liquid; Electrochemistry; Humans; Rats; Tyrosine | 1991 |
The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease.
Topics: Biogenic Monoamines; Biomarkers; Carbidopa; Humans; Levodopa; Middle Aged; Parkinson Disease; Tyrosine | 1991 |
In vivo pharmacokinetics of levodopa and 3-O-methyldopa in muscle. A microdialysis study.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Injections, Intravenous; Levodopa; Male; Muscles; Tyrosine | 1991 |
Continuous intravenous monitoring of levodopa and 3-O-methyldopa by microdialysis and high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Electrochemistry; Levodopa; Male; Microchemistry; Reference Standards; Regression Analysis; Tyrosine | 1991 |
Simultaneous determination of levodopa, its main metabolites and carbidopa in plasma by liquid chromatography.
Topics: 3,4-Dihydroxyphenylacetic Acid; Carbidopa; Chromatography, High Pressure Liquid; Chromatography, Liquid; Freeze Drying; Homovanillic Acid; Humans; Hydrogen-Ion Concentration; Levodopa; Solutions; Tyrosine | 1991 |
Distribution and kinetics of 3-O-methyl-6-[18F]fluoro-L-dopa in the rhesus monkey brain.
Topics: Animals; Brain; Fluorine Radioisotopes; Macaca mulatta; Radionuclide Imaging; Tyrosine | 1991 |
Concentrations of tyrosine, L-dihydroxyphenylalanine, dopamine, and 3-O-methyldopa in the cerebrospinal fluid of Parkinson's disease.
Topics: Aged; Dihydroxyphenylalanine; Dopamine; Humans; Middle Aged; Parkinson Disease; Tyrosine | 1991 |
Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's disease.
Topics: Animals; Catechol O-Methyltransferase Inhibitors; Catechols; Levodopa; Macaca fascicularis; Male; Nitriles; Parkinson Disease; Pentanones; Tyrosine | 1991 |
Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.
Topics: Animals; Benserazide; Benzophenones; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Electrochemistry; Erythrocytes; Half-Life; In Vitro Techniques; Levodopa; Male; Nitrophenols; Norepinephrine; Rats; Rats, Inbred Strains; Tolcapone; Tyrosine | 1990 |
Simultaneous high-performance liquid chromatographic analysis of carbidopa, levodopa and 3-O-methyldopa in plasma and carbidopa, levodopa and dopamine in urine using electrochemical detection.
Topics: Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 1990 |
Simple automated high-performance liquid chromatographic column-switching technique for the measurement of dopa and 3-O-methyldopa in plasma.
Topics: Animals; Autoanalysis; Benserazide; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Electrochemistry; Humans; In Vitro Techniques; Indicators and Reagents; Male; Rats; Specimen Handling; Tyrosine | 1990 |
Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat.
Topics: Amidines; Animals; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Electrochemistry; Female; Homovanillic Acid; Levodopa; Pyridones; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Effect of the new selective COMT inhibitor CGP 28014 A on the formation of 3-O-methyldopa (3OMD) in plasma of healthy subjects.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Homovanillic Acid; Humans; Male; Pyridones; Tyrosine | 1990 |
Interference of 3-O-methyldopa with L-dopa treatment for MPTP-induced parkinsonism in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Injections, Intravenous; Levodopa; Male; Mice; Mice, Inbred C57BL; Parkinson Disease, Secondary; Receptors, Dopamine; Tyrosine | 1990 |
Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys.
Topics: Animals; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Levodopa; Macaca fascicularis; Male; Pentanones; Tyrosine | 1990 |
Regional distribution of 3-O-methyl-DOPA in the cortex and subcortical structures in the rat: effect of aging.
Topics: Aging; Animals; Brain; Cerebral Cortex; Male; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans.
Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine | 1990 |
Plasma dopa and feeding.
Topics: Animal Feed; Animals; Dihydroxyphenylalanine; Dogs; Dopamine; Eating; Epinephrine; Norepinephrine; Time Factors; Tyrosine | 1989 |
A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100).
Topics: Antiparkinson Agents; Carbidopa; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Levodopa and 3-O-methyldopa plasma levels in parkinsonian patients with stable and fluctuating motor response.
Topics: Aged; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Increased dosage of carbidopa in parkinsonian patients on low carbidopa-levodopa regimen. Effect on levodopa bioavailability.
Topics: Aged; Aged, 80 and over; Biological Availability; Carbidopa; Dose-Response Relationship, Drug; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Treatment of idiopathic parkinsonism with L-dopa in the absence and presence of decarboxylase inhibitors: effects on plasma levels of L-dopa, dopa decarboxylase, catecholamines and 3-O-methyl-dopa.
Topics: Administration, Oral; Aged; Benserazide; Carboxy-Lyases; Catecholamines; Dopa Decarboxylase; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Phenytoin; Time Factors; Tyrosine | 1989 |
A new potential prodrug to improve the duration of L-dopa: L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine.
Topics: Animals; Biological Availability; Carbidopa; Chromatography, High Pressure Liquid; Dogs; Levodopa; Male; Prodrugs; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
Re-evaluation of the L-dopa loading effect on dopamine metabolism in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Inhibition of decarboxylase and levels of dopa and 3-O-methyldopa: a comparative study of benserazide versus carbidopa in rodents and of Madopar standard versus Madopar HBS in volunteers.
Topics: Administration, Oral; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Carbidopa; Delayed-Action Preparations; Dihydroxyphenylalanine; Dogs; Dopa Decarboxylase; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hydrazines; Kidney; Levodopa; Liver; Male; Mice; Rats; Time Factors; Tyrosine | 1987 |
A new method for the determination of L-dopa and 3-O-methyldopa in plasma and cerebrospinal fluid using gas chromatography and electron capture negative ion mass spectrometry.
Topics: Acetylation; Adult; Dihydroxyphenylalanine; Esterification; Gas Chromatography-Mass Spectrometry; Humans; Reference Values; Tyrosine | 1988 |
Free and conjugated plasma catecholamines, DOPA and 3-O-methyldopa in humans and in various animal species.
Topics: Adult; Animals; Catecholamines; Cats; Cattle; Chlorocebus aethiops; Dihydroxyphenylalanine; Dogs; Female; Guinea Pigs; Humans; Male; Middle Aged; Rabbits; Rats; Rats, Gunn; Rats, Inbred Strains; Species Specificity; Swine; Tyrosine; Ursidae | 1988 |
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.
Topics: Animals; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Interactions; Duodenum; Erythrocytes; In Vitro Techniques; Ketones; Levodopa; Liver; Male; Pentanones; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
The effect of carbidopa on plasma and muscle levels of L-dopa, dopamine, and their metabolites following L-dopa administration to rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Drug Synergism; Homovanillic Acid; Levodopa; Muscles; Rats; Tyrosine | 1988 |
Single-dose pharmacokinetics of Madopar HBS in patients and effect of food and antacid on the absorption of Madopar HBS in volunteers.
Topics: Adult; Antacids; Benserazide; Biological Availability; Delayed-Action Preparations; Drug Combinations; Eating; Gastric Mucosa; Humans; Hydrazines; Levodopa; Middle Aged; Stomach; Tyrosine | 1987 |
3-O-methyldopa and motor fluctuations in Parkinson's disease.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intravenous; Levodopa; Male; Middle Aged; Movement; Parkinson Disease; Tyrosine | 1987 |
3-O-methyldopa and the response to levodopa in Parkinson's disease.
Topics: Administration, Oral; Blood-Brain Barrier; Humans; Infusions, Intravenous; Levodopa; Parkinson Disease; Tyrosine | 1987 |
Determination of m- and p-O-methylated products of L-3,4-dihydroxyphenylalanine using high-performance liquid chromatography and electrochemical detection.
Topics: Animals; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Isomerism; Levodopa; Liver; Methylation; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Effects of L-dopa and L-3-methoxytyrosine on D-methamphetamine-induced motor activity and seizures induced by electroshock.
Topics: Animals; Brain; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Electroshock; Male; Methamphetamine; Methyl Ethers; Motor Activity; Norepinephrine; Rats; Seizures; Tyrosine | 1973 |
Simultaneous determination of 3,4-dihydroxyphenylalanine, 5-hydroxytryptophan, dopamine, 4-hydroxy-3-methoxyphenylalanine, norepinephrine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindoleacetic acid in rat cerebrospinal fl
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methyltyrosines; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Tryptophan; Tyrosine | 1982 |
Evaluation of transsphenoidal hypophysectomy in the management of patients with advanced malignant melanoma.
Topics: Adult; Evaluation Studies as Topic; Female; Humans; Hypophysectomy; Male; Melanoma; Methyltyrosines; Middle Aged; Neoplasm Metastasis; Palliative Care; Postoperative Complications; Prognosis; Radioimmunoassay; Skin Neoplasms; Tyrosine | 1983 |
Monoamine metabolites in human cerebrospinal fluid. HPLC/ED method.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alzheimer Disease; Chromatography, High Pressure Liquid; Depression; Dihydroxyphenylalanine; Electrochemistry; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Parkinson Disease; Phenylacetates; Subarachnoid Hemorrhage; Tryptophan; Tyrosine | 1984 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human serum by high-performance liquid chromatography.
Topics: Adult; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Epinephrine; Humans; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Tyrosine | 1984 |
The formation of 3-hydroxy-4-methoxyphenylalanine and 3-hydroxy-4-methoxyphenethylamine in plasma during L-DOPA therapy in patients with Parkinson's disease.
Topics: Aged; Dopamine; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Tyrosine | 1984 |
Effects of 3-OM-dopa on monoamine metabolism in rat brain.
Topics: alpha-Methyltyrosine; Animals; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Dopamine; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1983 |
Formation of 3-hydroxy-4-methoxyphenylalanine from 3,4-dihydroxyphenylalanine by rat liver homogenate.
Topics: Animals; Catechol O-Methyltransferase; Dihydroxyphenylalanine; In Vitro Techniques; Liver; Male; Methylation; Methyltyrosines; Rats; Tyrosine | 1980 |
A semiautomated method for the rapid determination of dopa: comparison of plasma and erythrocyte-dopa concentration in levodopa-treated patients.
Topics: Autoanalysis; Dihydroxyphenylalanine; Erythrocytes; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Spectrometry, Fluorescence; Tyrosine | 1982 |
3-O-methyldopa blocks dopa metabolism in rat corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Levodopa; Male; Methyltyrosines; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1982 |
3-o-methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway.
Topics: Animals; Corpus Striatum; Humans; Levodopa; Male; Methyltyrosines; Neural Pathways; Rats; Stereotyped Behavior; Substantia Nigra; Tyrosine | 1982 |
Quantitative microdialysis for studying the in vivo L-DOPA kinetics in blood and skeletal muscle of the dog.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Proteins; Calibration; Dialysis; Dogs; Dopamine; Injections, Intramuscular; Injections, Intravenous; Levodopa; Male; Methyldopa; Microchemistry; Muscle, Skeletal; Protein Binding; Reference Standards; Reproducibility of Results; Tyrosine | 1995 |
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Animals; Biogenic Monoamines; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Nitriles; Pyridones; Rats; Rats, Wistar; Stereotaxic Techniques; Tryptophan; Tyrosine | 1994 |
Sympathectomy does not modify the levels of dopa or dopamine in the rat dorsal root ganglion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Electrochemistry; Ganglia, Spinal; Guanethidine; Homovanillic Acid; Male; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Tyrosine | 1995 |
Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Dopamine; Homovanillic Acid; Humans; Levodopa; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1995 |
Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease.
Topics: Adult; Aged; Cerebrospinal Fluid Proteins; Dopamine; Female; Homovanillic Acid; Humans; Isoquinolines; Male; Middle Aged; Monoamine Oxidase; Parkinson Disease; Tetrahydroisoquinolines; Tyrosine | 1995 |
A decreased tubular uptake of dopa results in defective renal dopamine production in aged rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Aromatic-L-Amino-Acid Decarboxylases; Biological Transport; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Dopamine; Kidney; Kidney Cortex; Male; Microvilli; Monoamine Oxidase; Norepinephrine; Rats; Rats, Wistar; Regression Analysis; Tyrosine | 1995 |
L-DOPA metabolism in cortical and striatal tissues in an animal model of parkinsonism.
Topics: Animals; Dopamine; Levodopa; Male; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Tyrosine | 1995 |
Inhibition of catechol-O-methyltransferase (COMT) as well as tyrosine and tryptophan hydroxylase by the orally active iron chelator, 1,2-dimethyl-3-hydroxypyridin-4-one (L1, CP20), in rat brain in vivo.
Topics: Administration, Oral; Animals; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Deferiprone; Deferoxamine; Dopamine; Female; Hydroxyindoleacetic Acid; Iron Chelating Agents; Male; Pyridones; Rats; Serotonin; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1993 |
The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Benserazide; Benzophenones; Catalepsy; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Synergism; Haloperidol; Kinetics; Levodopa; Male; Mice; Mice, Inbred C57BL; Nitrophenols; Tolcapone; Tyrosine | 1994 |
Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease.
Topics: Brain Chemistry; Catalysis; Copper; DNA; DNA Damage; Dopamine; Humans; Hydrogen Peroxide; Iron; Levodopa; Oxidation-Reduction; Parkinson Disease; Tyrosine | 1994 |
Simultaneous determination of levodopa methyl ester, levodopa, 3-O-methyldopa and dopamine in plasma by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Oxidation-Reduction; Rats; Tyrosine | 1994 |
Pharmacokinetics of levodopa and carbidopa in rats following different routes of administration.
Topics: Absorption; Administration, Oral; Animals; Carbidopa; Chromatography, High Pressure Liquid; Half-Life; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Intubation, Gastrointestinal; Levodopa; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Tyrosine | 1994 |
Cell inward transport of L-DOPA and 3-O-methyl-L-DOPA in rat renal tubules.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Chromatography, High Pressure Liquid; In Vitro Techniques; Kidney Tubules; Levodopa; Male; Rats; Rats, Wistar; Tyrosine | 1994 |
The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Dogs; Dopamine; Extracellular Space; Half-Life; Injections, Intravenous; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1993 |
Simultaneous in vivo microdialysis in plasma and skeletal muscle: a study of the pharmacokinetic properties of levodopa by noncompartmental analysis.
Topics: Animals; Dogs; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1994 |
3-O-methyldopa attenuates the effects of Madopar on the haloperidol-induced cataleptic behavior and the locomotor activity in the mouse.
Topics: Animals; Benserazide; Catalepsy; Drug Combinations; Haloperidol; Levodopa; Male; Mice; Motor Activity; Tyrosine | 1994 |
Clinical pharmacology of the new COMT inhibitor CGP 28,014.
Topics: Amidines; Animals; Benserazide; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Isoquinolines; Kinetics; Methoxyhydroxyphenylglycol; Norepinephrine; Pyridones; Rats; Tyrosine; Vanilmandelic Acid | 1993 |
Suppression of dyskinesias in advanced Parkinson's disease. I. Continuous intravenous levodopa shifts dose response for production of dyskinesias but not for relief of parkinsonism in patients with advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Tyrosine | 1993 |
Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum.
Topics: Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Male; Nitriles; Nitrophenols; Rats; Rats, Sprague-Dawley; Tolcapone; Tyrosine | 1993 |
Plasma levels of levodopa and its main metabolites in parkinsonian patients after conventional and controlled-release levodopa-carbidopa associations.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Blood-Brain Barrier; Carbidopa; Delayed-Action Preparations; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
Does tolerance develop to levodopa? Comparison of 2- and 21-H levodopa infusions.
Topics: Aged; Carbidopa; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Tolerance; Dyskinesia, Drug-Induced; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Electrocardiography; Half-Life; Homovanillic Acid; Humans; Levodopa; Male; Nitriles; Reference Values; Tyrosine | 1993 |
Effects of 3-O-methyl on L-dopa-facilitated synthesis and efflux of dopamine from rat striatal slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Cerebrospinal Fluid; Corpus Striatum; Dopamine; Drug Interactions; Levodopa; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Tyrosine | 1995 |
Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: effect of the plasma 3-O-methyldopa fraction on data analysis.
Topics: Adult; Aged; Catechol O-Methyltransferase Inhibitors; Catechols; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Enzyme Inhibitors; Female; Fluorine Radioisotopes; Humans; Kinetics; Male; Middle Aged; Nitriles; Occipital Lobe; Parkinson Disease; Quality Control; Sensitivity and Specificity; Tomography, Emission-Computed; Tyrosine | 1996 |
Oxidative damage caused by free radicals produced during catecholamine autoxidation: protective effects of O-methylation and melatonin.
Topics: Catecholamines; Copper Sulfate; Deoxyepinephrine; Dopamine; Free Radicals; Levodopa; Melatonin; Methylation; Oxidation-Reduction; Phycoerythrin; Spectrometry, Fluorescence; Tyrosine | 1996 |
Tyrosine and tryptophan derivatives in pig lumbar cerebrospinal fluid. Effects of subchronic administration of dopa associated with benserazide.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Benserazide; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Kynurenine; Levodopa; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Swine; Tryptamines; Tryptophan; Tyrosine | 1996 |
Demethylation of 3-O-methyldopa in the kidney: a possible source for dopamine in urine.
Topics: Animals; Catechols; Dihydroxyphenylalanine; Dopamine; Kidney; Kidney Cortex; Kidney Tubules; Male; Methylation; Natriuresis; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Tyrosine | 1996 |
An in vivo comparison of the capacity of striatal versus extrastriatal brain regions to form dopamine from exogenously administered L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biotransformation; Brain Chemistry; Cerebellum; Dopamine; Dopamine Agents; Extracellular Space; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Occipital Lobe; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human platelets and plasma using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Aged; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1997 |
Determination of catecholamines and methoxycatecholamines excretion patterns in pig and rat urine by ion-exchange liquid chromatography with electrochemical detection.
Topics: Animals; Catecholamines; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Circadian Rhythm; Dopamine; Electrochemistry; Epinephrine; Linear Models; Metanephrine; Norepinephrine; Normetanephrine; Rats; Rats, Inbred F344; Reproducibility of Results; Sensitivity and Specificity; Swine; Tyrosine | 1997 |
Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Biomarkers; Catecholamines; Female; Hallucinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Isoquinolines; Levodopa; Male; Parkinson Disease; Reference Values; Regression Analysis; Tyrosine | 1996 |
A comparative study on neurochemistry of cerebrospinal fluid in advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Progression; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
Acute overdosage and intoxication with carbidopa/levodopa can be detected in the subacute stage by measurement of 3-o-methyldopa.
Topics: Aged; Carbidopa; Dose-Response Relationship, Drug; Drug Combinations; Drug Overdose; Humans; Levodopa; Male; Time Factors; Tyrosine | 1999 |
Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Biological Transport; Cells, Cultured; Cerebellum; Dopamine Agents; Drug Interactions; Endothelium, Vascular; Levodopa; Rats; Tyrosine | 1999 |
Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons.
Topics: Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Cell Survival; Cells, Cultured; Dopamine; Dopamine Agents; Enzyme Inhibitors; Levodopa; Mesencephalon; Neurons; Rats; S-Adenosylmethionine; Tyrosine | 2000 |
The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Callithrix; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hydrazines; Levodopa; Male; Motor Activity; Quinolones; Quinpirole; Thiophenes; Tyrosine | 2000 |
The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Kidney; Liver; Male; Neurons; Parkinson Disease; Rats; Tyrosine | 2000 |
The influence of L-dopa on methylation capacity in aromatic L-amino acid decarboxylase deficiency: biochemical findings in two patients.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypokinesia; Levodopa; Methoxyhydroxyphenylglycol; Methylation; Muscle Hypotonia; Tetrahydrofolates; Tyrosine | 2000 |
The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Biogenic Monoamines; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Drug Combinations; Enzyme Inhibitors; Haloperidol; Homovanillic Acid; Hydrazines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Tyrosine | 2001 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy.
Topics: Adolescent; Age Factors; Aging; Biogenic Monoamines; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Myoclonic Epilepsies, Progressive; Tryptophan; Tyrosine | 2001 |
Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2001 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Methylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2001 |
L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase.
Topics: Animals; Blotting, Western; Brain; Catechol O-Methyltransferase; Dopamine; Enzyme Induction; Kidney; Levodopa; Liver; Male; Methionine Adenosyltransferase; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tyrosine; Up-Regulation | 2001 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
3-OMD and homocysteine plasma levels in parkinsonian patients.
Topics: Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2002 |
Factors for susceptibility to episode recurrence in spontaneous recurrence of methamphetamine psychosis.
Topics: Dopamine; Female; Genetic Predisposition to Disease; Humans; Methamphetamine; Norepinephrine; Prisoners; Psychotic Disorders; Recurrence; Reference Values; Stress, Psychological; Substance-Related Disorders; Tyrosine | 2002 |
Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Behavior, Animal; Benzylamines; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Interactions; Haloperidol; Hippocampus; Homovanillic Acid; Hypothalamus; Locus Coeruleus; Male; Medial Forebrain Bundle; Nerve Degeneration; Neurotoxins; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin; Substantia Nigra; Thalamus; Tyrosine | 2003 |
Modifications of plasma and platelet levels of L-DOPA and its direct metabolites during treatment with tolcapone or entacapone in patients with Parkinson's disease.
Topics: Age Factors; Age of Onset; Aged; Antiparkinson Agents; Benzophenones; Blood Platelets; Catechols; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Nitrophenols; Parkinson Disease; Retrospective Studies; Sex Characteristics; Tolcapone; Tyrosine; Up-Regulation | 2003 |
Interference of the electrospray voltage on chromatographic separations using porous graphitic carbon columns.
Topics: Chromatography, Liquid; Dihydroxyphenylalanine; Dopamine; Electrochemistry; Graphite; Norepinephrine; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2004 |
Simultaneous determination of levodopa and 3-O-methyldopa in human plasma by liquid chromatography with electrochemical detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Levodopa; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2004 |
Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Benzylamines; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Locus Coeruleus; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Statistics, Nonparametric; Tyrosine | 2004 |
Effects of homocysteine on the dopaminergic system and behavior in rodents.
Topics: Adenosine; Animals; Behavior, Animal; Brain Chemistry; Catheterization; Chromatography, High Pressure Liquid; Dopamine; Homocysteine; Immunohistochemistry; Injections, Intraventricular; Male; Methylation; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Concise synthesis of all stereoisomers of beta-methoxytyrosine and determination of the absolute configuration of the residue in callipeltin A.
Topics: Animals; Depsipeptides; Porifera; Stereoisomerism; Tyrosine | 2005 |
Clinical (video) findings and cerebrospinal fluid neurotransmitters in 2 children with severe chronic bilirubin encephalopathy, including a former preterm infant without marked hyperbilirubinemia VIDEO.
Topics: Child; Developmental Disabilities; Female; Follow-Up Studies; Globus Pallidus; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hyperbilirubinemia; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Kernicterus; Magnetic Resonance Imaging; Neurotransmitter Agents; Tyrosine | 2005 |
Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Calibration; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Levodopa; Tyrosine | 2006 |
The role of 3-O-methyldopa in the side effects of L-dopa.
Topics: Animals; Antiparkinson Agents; Benzazepines; Brain Chemistry; Catecholamines; Cell Survival; Chromatography, High Pressure Liquid; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Levodopa; Male; Membrane Potentials; Mitochondrial Membranes; Motor Activity; PC12 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Dopamine D1; Synaptic Transmission; Tyrosine | 2008 |
Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis.
Topics: Adult; Aged; Biomarkers; Circadian Rhythm; Dihydroxyphenylalanine; Dopamine; Female; Humans; Linear Models; Male; Middle Aged; Restless Legs Syndrome; Severity of Illness Index; Spinal Puncture; Tyrosine; Tyrosine 3-Monooxygenase | 2009 |
Peripheral COMT inhibition prevents levodopa associated homocysteine increase.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Delayed-Action Preparations; Dihydroxyphenylalanine; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Time Factors; Tyrosine | 2009 |
Caffeic acid improves the bioavailability of L-dopa in rabbit plasma.
Topics: Animals; Caffeic Acids; Carbidopa; Coumaric Acids; Levodopa; Rabbits; Tyrosine | 2010 |
Tyrosine hydroxylase deficiency in three Greek patients with a common ancestral mutation.
Topics: Child, Preschool; Dihydroxyphenylalanine; DNA Mutational Analysis; Greece; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Leucine; Metabolic Diseases; Methoxyhydroxyphenylglycol; Mutation; Proline; Tyrosine; Tyrosine 3-Monooxygenase; Young Adult | 2010 |
Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox.
Topics: Adolescent; Adult; Animals; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool; Cytochrome P-450 CYP2D6; DNA Mutational Analysis; Dopamine; Female; Genetic Association Studies; Humans; Infant; Kidney Cortex; Male; Monophenol Monooxygenase; Rats; Tyramine; Tyrosine; Young Adult | 2010 |
Cysteinyl-glycine reduction as marker for levodopa-induced oxidative stress in Parkinson's disease patients.
Topics: Analysis of Variance; Antiparkinson Agents; Carbidopa; Dipeptides; Female; Humans; Levodopa; Male; Oxidative Stress; Parkinson Disease; Tyrosine | 2011 |
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxyphenylalanine; DNA Primers; Ear; Ear, Inner; Electroencephalography; Epilepsy; Fibroblast Growth Factor 3; Folate Receptor 1; Folic Acid Deficiency; Humans; Levodopa; Male; Molecular Sequence Data; Pyridoxal Phosphate; Radiography; Sequence Analysis, DNA; Skull; Syndrome; Tooth Abnormalities; Tyrosine | 2011 |
Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Biomarkers; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Progression; Dopa Decarboxylase; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Japan; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Prospective Studies; Treatment Outcome; Tyrosine | 2011 |
Effects of 3-O-methyldopa, L-3,4-dihydroxyphenylalanine metabolite, on locomotor activity and dopamine turnover in rats.
Topics: Animals; Antiparkinson Agents; Brain; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Motor Activity; Parkinson Disease; Rats; Rats, Wistar; Tyrosine | 2012 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
Pharmacokinetics of levodopa, carbidopa, and 3-O-methyldopa following 16-hour jejunal infusion of levodopa-carbidopa intestinal gel in advanced Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Biotransformation; Carbidopa; Chemistry, Pharmaceutical; Drug Combinations; Female; Gels; Germany; Humans; Infusion Pumps; Intestinal Absorption; Intubation, Gastrointestinal; Jejunum; Levodopa; Male; Middle Aged; Parkinson Disease; Sweden; Tyrosine | 2013 |
Diagnosis of aromatic L-amino acid decarboxylase deficiency by measuring 3-O-methyldopa concentrations in dried blood spots.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Calibration; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dried Blood Spot Testing; Humans; Infant; Infant, Newborn; Neonatal Screening; Quality Control; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Tyrosine | 2014 |
Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Topics: Benzophenones; Blood Chemical Analysis; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Nitriles; Nitrophenols; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Tolcapone; Tyrosine | 2015 |
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
Topics: Animals; Benzofurans; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Kinetics; Levodopa; Male; Metabolome; Methylation; Nitrophenols; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Substrate Specificity; Tolcapone; Tyrosine | 2015 |
Simultaneous estimation of levodopa, carbidopa and 3-oxymethyldopa in rat plasma using HPLC-ECD.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electrochemical Techniques; Levodopa; Limit of Detection; Male; Rats; Rats, Wistar; Tyrosine | 2016 |
3-O-methyldopa levels in newborns: Result of newborn screening for aromatic l-amino-acid decarboxylase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Female; Gestational Age; Humans; Infant, Newborn; Male; Mutation; Neonatal Screening; Neurotransmitter Agents; Tandem Mass Spectrometry; Tyrosine | 2016 |
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA.
Topics: Animals; Astrocytes; Catechol O-Methyltransferase Inhibitors; Catechols; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Levodopa; Mesencephalon; Neuroprotection; Neuroprotective Agents; Nitriles; Rats, Sprague-Dawley; Tyrosine | 2016 |
Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children.
Topics: Aromatic-L-Amino-Acid Decarboxylases; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dystonic Disorders; Fluorescence; Folate Receptor 1; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Limit of Detection; Methoxyhydroxyphenylglycol; Neuroaxonal Dystrophies; Reference Values; Reproducibility of Results; Tetrahydrofolates; Tyrosine | 2017 |
Levodopa, placebo and rotigotine change biomarker levels for oxidative stress.
Topics: Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dipeptides; Dopamine Agents; Electrochemical Techniques; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes; Time Factors; Tyrosine | 2017 |
Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancy.
Topics: Adolescent; Adrenal Gland Neoplasms; Aging; Blood Chemical Analysis; Catecholamines; Child; Child, Preschool; Chromatography, Liquid; Dopamine; Female; Humans; Infant; Infant, Newborn; Male; Metanephrine; Normetanephrine; Paraganglioma; Pheochromocytoma; Reference Values; Tandem Mass Spectrometry; Tyrosine | 2019 |
Biochemical testing for neuroblastoma using plasma free 3-O-methyldopa, 3-methoxytyramine, and normetanephrine.
Topics: Adolescent; Biomarkers, Tumor; Case-Control Studies; Child; Child, Preschool; Dopamine; Female; Follow-Up Studies; Humans; Infant; Male; Neuroblastoma; Normetanephrine; Prognosis; Retrospective Studies; Tyrosine | 2020 |
High throughput newborn screening for aromatic ʟ-amino-acid decarboxylase deficiency by analysis of concentrations of 3-O-methyldopa from dried blood spots.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Aromatic-L-Amino-Acid Decarboxylases; Case-Control Studies; Dried Blood Spot Testing; Female; High-Throughput Screening Assays; Humans; Infant, Newborn; Male; Neonatal Screening; Tandem Mass Spectrometry; Tyrosine | 2020 |
Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate.
Topics: 5-Hydroxytryptophan; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Pipecolic Acids; Pyridoxal; Pyridoxal Phosphate; Retrospective Studies; Tyrosine; Vitamin B 6; Young Adult | 2020 |
Cerebrospinal Fluid Pterins, Pterin-Dependent Neurotransmitters, and Mortality in Pediatric Cerebral Malaria.
Topics: Biopterins; Central Nervous System Diseases; Child; Child, Preschool; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Malaria, Cerebral; Male; Neopterin; Neurotransmitter Agents; Prospective Studies; Pterins; Reference Values; Tanzania; Tyrosine | 2021 |
Detection of 3-O-methyldopa in dried blood spots for neonatal diagnosis of aromatic L-amino-acid decarboxylase deficiency: The northeastern Italian experience.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Female; Humans; Infant, Newborn; Italy; Levodopa; Male; Neonatal Screening; Neurotransmitter Agents; Tandem Mass Spectrometry; Tyrosine | 2021 |
Effect of catechin and commercial preparation of green tea essence on the pharmacokinetics of l-dopa in rabbits.
Topics: Animals; Biological Availability; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, Liquid; Herb-Drug Interactions; Levodopa; Male; Rabbits; Reproducibility of Results; Tandem Mass Spectrometry; Tea; Tyrosine | 2021 |
Simultaneous determination of 5-hydroxytryptophan and 3-O-methyldopa in dried blood spot by UPLC-MS/MS: A useful tool for the diagnosis of L-amino acid decarboxylase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Tandem Mass Spectrometry; Tyrosine; Young Adult | 2021 |