3-methoxytyrosine has been researched along with levodopa in 123 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (19.51) | 18.7374 |
| 1990's | 55 (44.72) | 18.2507 |
| 2000's | 25 (20.33) | 29.6817 |
| 2010's | 15 (12.20) | 24.3611 |
| 2020's | 4 (3.25) | 2.80 |
| Authors | Studies |
|---|---|
| Clayton, PT; Hyland, K | 1 |
| Hasegawa, S; Konagaya, Y; Maruyama, W; Mokuno, K; Nakahara, D; Naoi, M; Takahashi, A; Watanabe, H | 1 |
| Bjurling, P; Gillberg, PG; Långström, B; Miwa, S; Odano, I; Watanabe, Y; Yumoto, N | 1 |
| Kaakkola, S; Männistö, PT; Tuomainen, P; Wurtman, RJ | 1 |
| Jenner, P; Marsden, CD; Rose, S | 2 |
| Abe, T; Kikuchi, T; Nozaki, Y; Takahashi, S; Tohgi, H | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S | 3 |
| Deleu, D; Ebinger, G; Herregodts, P; Michotte, Y; Sarre, S | 1 |
| Wikberg, T | 1 |
| Cedarbaum, JM; Guttman, M; Leger, G | 1 |
| Colzi, A; Da Prada, M; Zürcher, G | 1 |
| August, TF; Bayne, WF; Eisenhandler, R; Musson, DG; Titus, DC; Yeh, KC | 1 |
| De Herdt, P; Maitre, L; Waldmeier, PC | 1 |
| Fujitake, J; Kuno, S; Mizuta, E | 1 |
| Cedarbaum, JM; Guttman, M; Léger, G; Reches, A | 1 |
| Hyland, K; Surtees, R | 1 |
| Cedarbaum, JM; Kutt, H; McDowell, FH | 2 |
| August, TF; Bush, DF; Lasseter, KC; Musson, DG; Schwartz, S; Smith, ME; Titus, DC; Yeh, KC | 1 |
| Berchou, RC; Galloway, MP; Kareti, D; Kesaree, N; LeWitt, PA; Nelson, MV; Schlick, P | 1 |
| Luquin, MR; Obeso, JA; Vaamonde, J | 1 |
| Baruzzi, A; Contin, M; Martinelli, P; Procaccianti, G; Riva, R | 1 |
| Boomsma, F; Hovestadt, A; Man in't Veld, AJ; Meerwaldt, JD; Schalekamp, MA | 1 |
| Hisaka, A; Ihara, M; Sawasaki, Y; Takehana, H; Tomimoto, K; Tsuchiya, Y; Yano, M | 1 |
| Cohen, Y; el Gemayel, G; Jacquot, C; Prioux-Guyonneau, M; Trouvin, JH | 1 |
| Da Prada, M; Haefely, WE; Kettler, R; Schaffner, R; Zürcher, G | 1 |
| Kaakkola, S; Lindén, IB; Männistö, PT; Nissinen, E; Pohto, P; Schultz, E | 1 |
| Allen, JG; Bird, H; Malcolm, SL; Marion, MH; Marsden, CD; O'Leary, CG; Quinn, NP | 1 |
| Allen, JG; Hardie, RJ; Lees, AJ; Malcolm, SL; Stern, GM | 1 |
| Chase, TN; Fabbrini, G; Juncos, JL; Mouradian, MM; Serrati, C | 1 |
| Gancher, ST; Merrick, D; Nutt, JG; Woodward, WR | 1 |
| Hirose, S; Ishimitsu, T | 1 |
| Fellman, JH; Nutt, JG | 1 |
| Beers, MF; Hurtig, H; Melvin, G; Scarpa, A; Stern, M | 1 |
| Asahara, K; Hirose, S; Imaizumi, M; Ishimitsu, T | 1 |
| Aguado, EG; Bazán, E; de Yébenes, JG; Gervas, JJ; Muradás, V | 1 |
| Fahn, S; Prasad, AL | 1 |
| Fahn, S; Reches, A | 1 |
| Fahn, S; Mielke, LR; Reches, A | 1 |
| Deleu, D; Ebinger, G; Michotte, Y; Sarre, S; Van Belle, K | 1 |
| Kaakkola, S; Kask, A; Männistö, PT; Törnwall, M; Tuomainen, P | 1 |
| Abe, T; Saheki, M; Takahashi, S; Tohgi, H; Tsukamoto, Y; Yamazaki, K | 1 |
| Carey, RJ; Dai, H; Huston, JP; Pinheiro-Carrera, M; Schwarting, RK; Tomaz, C | 1 |
| Himori, N; Mishima, K | 1 |
| Aruoma, OI; Dexter, DT; Evans, PJ; Halliwell, B; Jenner, A; Jenner, P; Kaur, H; Lees, AJ; Marsden, DC; Spencer, JP | 1 |
| Acerbi, D; Mariotti, F; Rondelli, I; Ventura, P | 1 |
| Bredberg, E; Lennernäs, H; Paalzow, L | 1 |
| Fernandes, MH; Pinto-do-O, PC; Soares-da-Silva, P | 1 |
| Akaike, N; Himori, N; Kurasawa, M; Mishima, K; Tanaka, Y | 1 |
| Bennett, JP; Schuh, LA | 1 |
| Baraldo, M; Benetello, P; Furlanut, M; Hassan, E; Zara, G | 1 |
| Carter, JH; Gancher, ST; Hammerstad, JP; Nutt, JG; Woodward, W | 1 |
| Gordin, A; Harjola, VP; Karlsson, M; Keränen, T; Korpela, K; Pentikäinen, PJ; Rita, H; Seppälä, L; Wikberg, T | 1 |
| Cohen, G; DiRocco, A; Merchant, CA; Molinari, S; Moros, D; Mytilineou, C; Yahr, MD | 1 |
| Chang, WY; Webster, RA | 1 |
| Rinne, UK; Ruottinen, HM | 1 |
| Joseph, JA; Miller, JW; Selhub, J | 1 |
| Antila, S; Gordin, A; Keränen, T; Koulu, M; Scheinin, M; Sundberg, S; Wikberg, T | 1 |
| Achilli, G; Banting, A; Banting, S; Le Bars, D; Weil-Fugazza, J | 1 |
| O'Connell, MT; Patsalos, PN; Quinn, NP; Tison, F | 1 |
| Brannan, T; Prikhojan, A; Yahr, MD | 1 |
| Hattori, Y; Kanazawa, I; Kowa, H; Kuno, S; Mizuno, Y; Narabayashi, H; Tohgi, H; Tsukamoto, Y; Yamamoto, M; Yanagisawa, N; Yokochi, M | 1 |
| Crevoisier, C; Dingemanse, J; Kleinbloesem, CH; Wood, ND; Zürcher, G | 1 |
| Baraldo, M; Benetello, P; Fortunato, M; Furlanut, M; Pea, F | 1 |
| Antkiewicz-Michaluk, L; Krygowska-Wajs, A; Romańska, I; Szczudlik, A; Vetulani, J | 1 |
| Blandini, F; Desideri, S; Martignoni, E; Nappi, G; Pacchetti, C; Rivellini, D | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Kleinbloesem, CH; Lankhaar, G | 1 |
| Jaskowski, P; Kömpf, D; Moser, A; Siebecker, F; Vieregge, P | 1 |
| Crevoisier, C; Dingemanse, J; Gasser, UE; Lankhaar, G; Ouwerkerk, M | 1 |
| Beiske, A; Fotteler, B; Jorga, KM; Larsen, JP; Moe, B; Schleimer, M; Schmitt, M | 1 |
| Buchholz, J; Iacono, RP; Kuniyoshi, S; Liu, H; Schoonenberg, T | 1 |
| Furlanut, M; Wu, G | 1 |
| Schoser, BG; Stuerenburg, HJ | 1 |
| Blandini, F; Desideri, S; Godi, L; Mancini, F; Martignoni, E; Nappi, G; Pacchetti, C | 1 |
| Gomes, P; Soares-da-Silva, P | 1 |
| Blandini, F; di Jeso, F; Martignoni, E; Nappi, G; Ricotti, R | 1 |
| Bareiss, M; Blessing, H; Carvey, P; Jankowski, S; Ling, ZD; Schwarz, J; Storch, A | 1 |
| Jackson, M; Jenner, P; Treseder, SA | 1 |
| Bräutigam, C; Hoffman, GF; Hyland, K; Knust, A; Sharma, RK; Wevers, RA | 1 |
| Jenner, P; Rose, S; Treseder, SA | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Blandini, F; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Samuele, A | 1 |
| Hainzl, D; Loureiro, AI; Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Charlton, CG; Lamango, N; Latinwo, L; Lee, ES; Liu, XX; Zhao, WQ | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| Fowler, B; Kuhn, W; Müller, T; Woitalla, D | 1 |
| Calvi-Gries, F; Crevoisier, C; Nilsen, T; Zerr, P | 1 |
| Blandini, F; Bono, G; Calandrella, D; Fancellu, R; Mangiagalli, A; Martignoni, E; Nappi, G; Pacchetti, C; Riboldazzi, G; Samuele, A | 1 |
| Almeida, L; Falcão, A; Loureiro, A; Machado, R; Maia, J; Silveira, P; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Masuda, N; Nagae, Y; Nakashima, A; Niina, M; Saxer, C | 1 |
| Schmidt, WJ; Srinivasan, J | 1 |
| Muhlack, S; Müller, T; Przuntek, H; Twiehaus, S; Welnic, J; Woitalla, D | 1 |
| Carl, JL; Karimi, M; Loftin, S; Perlmutter, JS | 1 |
| Bremen, D; Erdmann, C; Goetze, O; Muhlack, S; Müller, T; Przuntek, H; Woitalla, D | 1 |
| Muhlack, S; Müller, T; Welnic, J | 1 |
| Ander, L; Kolf, K; Muhlack, S; Müller, T; Woitalla, D | 1 |
| Charlton, C; Chen, H; King, J; Lee, ES | 1 |
| Almeida, L; Costa, R; Falcão, A; Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, J; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Kuhn, W; Müller, T | 1 |
| Muhlack, S; Müller, T | 2 |
| Almeida, L; Costa, R; Falcão, A; Fernandes-Lopes, C; Loureiro, AI; Machado, R; Nunes, T; Rocha, JF; Soares-da-Silva, P; Torrão, L; Vaz-da-Silva, M; Wright, L | 1 |
| Hsu, FL; Hsu, KY; Lin, SJ; Uang, YS; Wang, LH; Yang, LM | 1 |
| Adamiak, U; Bialecka, M; Gawronska-Szklarz, B; Kaldonska, M; Klodowska-Duda, G; Safranow, K; Wyska, E | 1 |
| Muhlack, S; Müller, T; Woitalla, D | 1 |
| Blau, N; Dill, P; Jakobs, C; Schneider, J; Tekin, M; Thöny, B; Trachsel, D; Weber, P | 1 |
| Ishihara, A; Kihira, K; Kimura, Y; Matsumoto, M; Miyachi, T; Nakamura, T; Ohtsuki, T; Yamawaki, T | 1 |
| Askmark, H; Johansson, A; Lennernäs, H; Nyholm, D | 1 |
| Hirosawa, T; Kihira, K; Kimura, Y; Onzawa, Y; Shirasuna, M; Taogoshi, T; Uzuhashi, K | 1 |
| Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Chatamra, K; Dutta, S; Johansson, A; Locke, C; Nyholm, D; Odin, P; Othman, AA | 1 |
| Cardoso, MA; de Carvalho, KA; de Francisco, TM; de Oliveira Vilhena, R; Gasparetto, JC; Guimarães de Francisco, TM; Martins, CA; Pontarolo, R; Ribeiro, RP | 1 |
| Cao, L; Hao, H; Hao, K; Li, F; Liu, H; Qi, Q; Wang, H | 1 |
| Bishnoi, P; Charde, SY; Raut, PP | 1 |
| Asanuma, M; Miyazaki, I | 1 |
| Herrman, L; Kinkel, M; Muhlack, S; Müller, T | 1 |
| Blau, N; Burlina, A; Burlina, AP; Cazzorla, C; Giuliani, A; Gragnaniello, V; Gueraldi, D; Hoffmann, G; Opladen, T; Polo, G | 1 |
| Ho, Y; Hsu, KY; Huang, YJ; Lin, SJ; Tai, L; Uang, YS; Wang, LH | 1 |
| Cawley, A; Fu, S; Keen, B; Loy, J; Noble, G; Reedy, B | 1 |
| Demizu, Y; Ikeda, K; Shoda, T; Tsuji, G | 1 |
1 review(s) available for 3-methoxytyrosine and levodopa
| Article | Year |
|---|---|
Pharmacokinetics of levodopa.
Topics: Administration, Oral; Age Factors; Amino Acids; Biological Availability; Biological Transport; Biotransformation; Blood-Brain Barrier; Gastric Emptying; Humans; Intestinal Absorption; Kinetics; Levodopa; Methyltyrosines; Time Factors; Tissue Distribution; Tyrosine | 1984 |
30 trial(s) available for 3-methoxytyrosine and levodopa
| Article | Year |
|---|---|
Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Biological Availability; Carbidopa; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combinations; Fasting; Half-Life; Humans; Intestinal Absorption; Levodopa; Middle Aged; Parkinson Disease; Random Allocation; Reference Values; Tablets; Tyrosine | 1989 |
Controlled-release carbidopa/levodopa (Sinemet 50/200 CR4): clinical and pharmacokinetic studies.
Topics: Aged; Antiparkinson Agents; Carbidopa; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Humans; Levodopa; Middle Aged; Parkinson Disease; Random Allocation; Tyrosine | 1989 |
Clinical significance of the relationship between O-methyldopa levels and levodopa intake.
Topics: Animals; Carbidopa; Corpus Striatum; Delayed-Action Preparations; Drug Combinations; Female; Humans; Levodopa; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
The pharmacokinetics of intravenous and oral levodopa in patients with Parkinson's disease who exhibit on-off fluctuations.
Topics: Absorption; Administration, Oral; Adult; Carboxy-Lyases; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Half-Life; Humans; Infusions, Intravenous; Kinetics; Levodopa; Male; Middle Aged; Parkinson Disease; Random Allocation; Tyrosine | 1986 |
Human transplacental transfer of carbidopa/levodopa.
Topics: Antiparkinson Agents; Carbidopa; Dopamine; Female; Fetus; Homovanillic Acid; Humans; Levodopa; Maternal-Fetal Exchange; Parkinson Disease; Pregnancy; Tyrosine | 1995 |
Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients.
Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine Agents; Double-Blind Method; Enzyme Inhibitors; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 1996 |
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers.
Topics: Adult; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Cross-Over Studies; Dopamine; Double-Blind Method; Enzyme Inhibitors; Human Growth Hormone; Humans; Levodopa; Male; Nitriles; Placebos; Prolactin; Tyrosine | 1996 |
Clinical drug monitoring by microdialysis: application to levodopa therapy in Parkinson's disease.
Topics: Antiparkinson Agents; Area Under Curve; Drug Monitoring; Half-Life; Humans; Levodopa; Microdialysis; Parkinson Disease; Tyrosine | 1996 |
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Area Under Curve; Benzophenones; Catechol O-Methyltransferase Inhibitors; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1997 |
Pharmacodynamics of benserazide assessed by its effects on endogenous and exogenous levodopa pharmacokinetics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antiparkinson Agents; Benserazide; Carboxy-Lyases; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Levodopa and 3-O-methyldopa in cerebrospinal fluid after levodopa-carbidopa association.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Drug Combinations; Electrochemistry; Female; Humans; Levodopa; Male; Middle Aged; Tyrosine | 1997 |
Increase in salsolinol level in the cerebrospinal fluid of parkinsonian patients is related to dementia: advantage of a new high-performance liquid chromatography methodology.
Topics: Adult; Aged; Antiparkinson Agents; Chromatography, High Pressure Liquid; Dementia; Female; Homovanillic Acid; Humans; Isoquinolines; Levodopa; Male; Middle Aged; Parkinson Disease; Psychiatric Status Rating Scales; Tyrosine | 1997 |
Pharmacokinetic studies with a dual-release formulation of levodopa, a novel principle in the treatment of Parkinson's disease.
Topics: Adolescent; Adult; Antiparkinson Agents; Cross-Over Studies; Delayed-Action Preparations; Female; Food; Humans; Levodopa; Male; Parkinson Disease; Tablets; Tyrosine | 1998 |
Comparative single- and multiple-dose pharmacokinetics of levodopa and 3-O-methyldopa following a new dual-release and a conventional slow-release formulation of levodopa and benserazide in healthy subjects.
Topics: Benserazide; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Humans; Levodopa; Metabolic Clearance Rate; Time Factors; Tyrosine | 1998 |
The effect of tolcapone on the pharmacokinetics of benserazide.
Topics: Aged; Antiparkinson Agents; Benserazide; Benzophenones; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hydrazines; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Time Factors; Tolcapone; Tyrosine | 1999 |
Pharmacodynamic modelling of levodopa, 3-O-methyldopa and their effects: an application of the Dixon equation.
Topics: Aged; Drug Interactions; Female; Humans; Levodopa; Male; Models, Statistical; Parkinson Disease; Tyrosine | 1999 |
Peripheral markers of oxidative stress in Parkinson's disease. The role of L-DOPA.
Topics: Antiparkinson Agents; Biomarkers; Blood Platelets; Dopamine; Female; Gentisates; Humans; Hydroxybenzoates; Hydroxyl Radical; In Vitro Techniques; Levodopa; Linear Models; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Sodium Salicylate; Superoxide Dismutase; Tyrosine | 1999 |
Determination of hydroxyl free radical formation in human platelets using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Hydroxybenzoates; Hydroxyl Radical; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
Effects of food on the pharmacokinetics of levodopa in a dual-release formulation.
Topics: Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Drug Administration Schedule; Drug Combinations; Fasting; Female; Food; Food-Drug Interactions; Half-Life; Humans; Levodopa; Male; Time Factors; Tyrosine | 2003 |
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine | 2003 |
Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease.
Topics: Adult; Aged; Analysis of Variance; Antiparkinson Agents; Area Under Curve; Benserazide; Biological Availability; Dihydroxyphenylalanine; Drug Administration Routes; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Time Factors; Tyrosine | 2004 |
Pharmacokinetic behaviour of levodopa and 3-O-methyldopa after repeat administration of levodopa/carbidopa with and without entacapone in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Tyrosine | 2006 |
Acute levodopa administration reduces cortisol release in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Benserazide; Down-Regulation; Enzyme Inhibitors; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Levodopa; Male; Middle Aged; Neural Pathways; Parkinson Disease; Raphe Nuclei; Serotonin; Tyrosine | 2007 |
Comparison of 200 mg retarded release levodopa/carbidopa - with 150 mg levodopa/carbidopa/entacapone application: pharmacokinetics and efficacy in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Carbidopa; Catechols; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 2007 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor, and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in healthy subjects.
Topics: Acetophenones; Adult; Antiparkinson Agents; Area Under Curve; Carbidopa; Catechol O-Methyltransferase Inhibitors; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Humans; Levodopa; Male; Time Factors; Tyrosine; Young Adult | 2008 |
Homocysteine levels after acute levodopa intake in patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Severity of Illness Index; Statistics as Topic; Time Factors; Tyrosine | 2009 |
Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide: a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects.
Topics: Acetophenones; Adolescent; Adult; Antiparkinson Agents; Area Under Curve; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Middle Aged; Tyrosine; Young Adult | 2009 |
Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.
Topics: Age of Onset; Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Therapy, Combination; Dyskinesias; Enzyme Inhibitors; Female; Half-Life; Humans; Levodopa; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Nitrophenols; Parkinson Disease; Severity of Illness Index; Tolcapone; Tyrosine | 2010 |
Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Biological Availability; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Combinations; Drug Therapy, Combination; Female; Half-Life; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Tyrosine | 2011 |
Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechols; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Nitrophenols; Parkinson Disease; Pilot Projects; Self Report; Single-Blind Method; Sweden; Tolcapone; Tyrosine | 2012 |
92 other study(ies) available for 3-methoxytyrosine and levodopa
| Article | Year |
|---|---|
Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology.
Topics: 5-Hydroxytryptophan; Aromatic-L-Amino-Acid Decarboxylases; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dopa Decarboxylase; Gas Chromatography-Mass Spectrometry; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Levodopa; Liver; Metabolism, Inborn Errors; Reference Values; Tyrosine | 1992 |
The mechanism of perturbation in monoamine metabolism by L-dopa therapy: in vivo and in vitro studies.
Topics: Aged; Amino Acids; Animals; Biogenic Monoamines; Corpus Striatum; Dialysis; Dopamine; Female; Humans; In Vitro Techniques; Kinetics; Levodopa; Male; Middle Aged; Neurons; Parkinson Disease; PC12 Cells; Rats; Tryptophan Hydroxylase; Tyrosine; Tyrosine 3-Monooxygenase | 1992 |
Assessment of dopamine and its metabolites in the intracellular and extracellular compartments of the rat striatum after peripheral administration of L-[11C]dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Extracellular Space; Homovanillic Acid; Injections, Intravenous; Intracellular Fluid; Kinetics; Levodopa; Male; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Corpus Striatum; Depression, Chemical; Dialysis; Dopamine; Homovanillic Acid; Hypothalamus; Injections, Intraperitoneal; Levodopa; Male; Perfusion; Rats; Rats, Inbred Strains; Tyrosine | 1992 |
Peripheral pharmacokinetic handling and metabolism of L-dopa in the rat: the effect of route of administration and carbidopa pretreatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Aorta, Thoracic; Carbidopa; Chromatography, High Pressure Liquid; Homovanillic Acid; Injections, Intravenous; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1991 |
The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson's disease.
Topics: Biogenic Monoamines; Biomarkers; Carbidopa; Humans; Levodopa; Middle Aged; Parkinson Disease; Tyrosine | 1991 |
In vivo pharmacokinetics of levodopa and 3-O-methyldopa in muscle. A microdialysis study.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Injections, Intravenous; Levodopa; Male; Muscles; Tyrosine | 1991 |
Continuous intravenous monitoring of levodopa and 3-O-methyldopa by microdialysis and high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dialysis; Dogs; Electrochemistry; Levodopa; Male; Microchemistry; Reference Standards; Regression Analysis; Tyrosine | 1991 |
Simultaneous determination of levodopa, its main metabolites and carbidopa in plasma by liquid chromatography.
Topics: 3,4-Dihydroxyphenylacetic Acid; Carbidopa; Chromatography, High Pressure Liquid; Chromatography, Liquid; Freeze Drying; Homovanillic Acid; Humans; Hydrogen-Ion Concentration; Levodopa; Solutions; Tyrosine | 1991 |
Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's disease.
Topics: Animals; Catechol O-Methyltransferase Inhibitors; Catechols; Levodopa; Macaca fascicularis; Male; Nitriles; Parkinson Disease; Pentanones; Tyrosine | 1991 |
Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.
Topics: Animals; Benserazide; Benzophenones; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Electrochemistry; Erythrocytes; Half-Life; In Vitro Techniques; Levodopa; Male; Nitrophenols; Norepinephrine; Rats; Rats, Inbred Strains; Tolcapone; Tyrosine | 1990 |
Simultaneous high-performance liquid chromatographic analysis of carbidopa, levodopa and 3-O-methyldopa in plasma and carbidopa, levodopa and dopamine in urine using electrochemical detection.
Topics: Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 1990 |
Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat.
Topics: Amidines; Animals; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Electrochemistry; Female; Homovanillic Acid; Levodopa; Pyridones; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Interference of 3-O-methyldopa with L-dopa treatment for MPTP-induced parkinsonism in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dopamine; Injections, Intravenous; Levodopa; Male; Mice; Mice, Inbred C57BL; Parkinson Disease, Secondary; Receptors, Dopamine; Tyrosine | 1990 |
Effect of nitecapone (OR-462) on the pharmacokinetics of levodopa and 3-O-methyldopa formation in cynomolgus monkeys.
Topics: Animals; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Levodopa; Macaca fascicularis; Male; Pentanones; Tyrosine | 1990 |
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans.
Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NADH, NADPH Oxidoreductases; Phenylketonurias; Pyridoxine; S-Adenosylmethionine; Tetrahydrofolates; Tyrosine | 1990 |
A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100).
Topics: Antiparkinson Agents; Carbidopa; Drug Combinations; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Levodopa and 3-O-methyldopa plasma levels in parkinsonian patients with stable and fluctuating motor response.
Topics: Aged; Carbidopa; Dyskinesia, Drug-Induced; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Increased dosage of carbidopa in parkinsonian patients on low carbidopa-levodopa regimen. Effect on levodopa bioavailability.
Topics: Aged; Aged, 80 and over; Biological Availability; Carbidopa; Dose-Response Relationship, Drug; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1989 |
Treatment of idiopathic parkinsonism with L-dopa in the absence and presence of decarboxylase inhibitors: effects on plasma levels of L-dopa, dopa decarboxylase, catecholamines and 3-O-methyl-dopa.
Topics: Administration, Oral; Aged; Benserazide; Carboxy-Lyases; Catecholamines; Dopa Decarboxylase; Drug Combinations; Drug Therapy, Combination; Female; Humans; Levodopa; Longitudinal Studies; Male; Middle Aged; Parkinson Disease; Phenytoin; Time Factors; Tyrosine | 1989 |
A new potential prodrug to improve the duration of L-dopa: L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine.
Topics: Animals; Biological Availability; Carbidopa; Chromatography, High Pressure Liquid; Dogs; Levodopa; Male; Prodrugs; Rats; Rats, Inbred Strains; Tyrosine | 1989 |
Re-evaluation of the L-dopa loading effect on dopamine metabolism in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Drug Therapy, Combination; Homovanillic Acid; Levodopa; Male; Rats; Rats, Inbred Strains; Tyrosine | 1986 |
Inhibition of decarboxylase and levels of dopa and 3-O-methyldopa: a comparative study of benserazide versus carbidopa in rodents and of Madopar standard versus Madopar HBS in volunteers.
Topics: Administration, Oral; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Carbidopa; Delayed-Action Preparations; Dihydroxyphenylalanine; Dogs; Dopa Decarboxylase; Dose-Response Relationship, Drug; Drug Combinations; Humans; Hydrazines; Kidney; Levodopa; Liver; Male; Mice; Rats; Time Factors; Tyrosine | 1987 |
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.
Topics: Animals; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Drug Interactions; Duodenum; Erythrocytes; In Vitro Techniques; Ketones; Levodopa; Liver; Male; Pentanones; Rats; Rats, Inbred Strains; Tyrosine | 1988 |
The effect of carbidopa on plasma and muscle levels of L-dopa, dopamine, and their metabolites following L-dopa administration to rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Drug Synergism; Homovanillic Acid; Levodopa; Muscles; Rats; Tyrosine | 1988 |
Single-dose pharmacokinetics of Madopar HBS in patients and effect of food and antacid on the absorption of Madopar HBS in volunteers.
Topics: Adult; Antacids; Benserazide; Biological Availability; Delayed-Action Preparations; Drug Combinations; Eating; Gastric Mucosa; Humans; Hydrazines; Levodopa; Middle Aged; Stomach; Tyrosine | 1987 |
3-O-methyldopa and motor fluctuations in Parkinson's disease.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intravenous; Levodopa; Male; Middle Aged; Movement; Parkinson Disease; Tyrosine | 1987 |
3-O-methyldopa and the response to levodopa in Parkinson's disease.
Topics: Administration, Oral; Blood-Brain Barrier; Humans; Infusions, Intravenous; Levodopa; Parkinson Disease; Tyrosine | 1987 |
Determination of m- and p-O-methylated products of L-3,4-dihydroxyphenylalanine using high-performance liquid chromatography and electrochemical detection.
Topics: Animals; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Isomerism; Levodopa; Liver; Methylation; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human serum by high-performance liquid chromatography.
Topics: Adult; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Epinephrine; Humans; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Tyrosine | 1984 |
The formation of 3-hydroxy-4-methoxyphenylalanine and 3-hydroxy-4-methoxyphenethylamine in plasma during L-DOPA therapy in patients with Parkinson's disease.
Topics: Aged; Dopamine; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Tyrosine | 1984 |
Effects of 3-OM-dopa on monoamine metabolism in rat brain.
Topics: alpha-Methyltyrosine; Animals; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Dopamine; Levodopa; Male; Methyltyrosines; Norepinephrine; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1983 |
A semiautomated method for the rapid determination of dopa: comparison of plasma and erythrocyte-dopa concentration in levodopa-treated patients.
Topics: Autoanalysis; Dihydroxyphenylalanine; Erythrocytes; Humans; Levodopa; Methyltyrosines; Parkinson Disease; Spectrometry, Fluorescence; Tyrosine | 1982 |
3-O-methyldopa blocks dopa metabolism in rat corpus striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Levodopa; Male; Methyltyrosines; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1982 |
3-o-methyldopa inhibits rotations induced by levodopa in rats after unilateral destruction of the nigrostriatal pathway.
Topics: Animals; Corpus Striatum; Humans; Levodopa; Male; Methyltyrosines; Neural Pathways; Rats; Stereotyped Behavior; Substantia Nigra; Tyrosine | 1982 |
Quantitative microdialysis for studying the in vivo L-DOPA kinetics in blood and skeletal muscle of the dog.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Proteins; Calibration; Dialysis; Dogs; Dopamine; Injections, Intramuscular; Injections, Intravenous; Levodopa; Male; Methyldopa; Microchemistry; Muscle, Skeletal; Protein Binding; Reference Standards; Reproducibility of Results; Tyrosine | 1995 |
Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amidines; Animals; Biogenic Monoamines; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Nitriles; Pyridones; Rats; Rats, Wistar; Stereotaxic Techniques; Tryptophan; Tyrosine | 1994 |
Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Dopamine; Homovanillic Acid; Humans; Levodopa; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 1995 |
L-DOPA metabolism in cortical and striatal tissues in an animal model of parkinsonism.
Topics: Animals; Dopamine; Levodopa; Male; Neostriatum; Oxidopamine; Parkinson Disease, Secondary; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Tyrosine | 1995 |
The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Benserazide; Benzophenones; Catalepsy; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Drug Synergism; Haloperidol; Kinetics; Levodopa; Male; Mice; Mice, Inbred C57BL; Nitrophenols; Tolcapone; Tyrosine | 1994 |
Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease.
Topics: Brain Chemistry; Catalysis; Copper; DNA; DNA Damage; Dopamine; Humans; Hydrogen Peroxide; Iron; Levodopa; Oxidation-Reduction; Parkinson Disease; Tyrosine | 1994 |
Simultaneous determination of levodopa methyl ester, levodopa, 3-O-methyldopa and dopamine in plasma by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Humans; Levodopa; Oxidation-Reduction; Rats; Tyrosine | 1994 |
Pharmacokinetics of levodopa and carbidopa in rats following different routes of administration.
Topics: Absorption; Administration, Oral; Animals; Carbidopa; Chromatography, High Pressure Liquid; Half-Life; Injections, Intra-Arterial; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Intubation, Gastrointestinal; Levodopa; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Tyrosine | 1994 |
Cell inward transport of L-DOPA and 3-O-methyl-L-DOPA in rat renal tubules.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Chromatography, High Pressure Liquid; In Vitro Techniques; Kidney Tubules; Levodopa; Male; Rats; Rats, Wistar; Tyrosine | 1994 |
The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carbidopa; Dogs; Dopamine; Extracellular Space; Half-Life; Injections, Intravenous; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1993 |
Simultaneous in vivo microdialysis in plasma and skeletal muscle: a study of the pharmacokinetic properties of levodopa by noncompartmental analysis.
Topics: Animals; Dogs; Levodopa; Male; Microdialysis; Muscles; Tyrosine | 1994 |
3-O-methyldopa attenuates the effects of Madopar on the haloperidol-induced cataleptic behavior and the locomotor activity in the mouse.
Topics: Animals; Benserazide; Catalepsy; Drug Combinations; Haloperidol; Levodopa; Male; Mice; Motor Activity; Tyrosine | 1994 |
Suppression of dyskinesias in advanced Parkinson's disease. I. Continuous intravenous levodopa shifts dose response for production of dyskinesias but not for relief of parkinsonism in patients with advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Carbidopa; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Combinations; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Tyrosine | 1993 |
Plasma levels of levodopa and its main metabolites in parkinsonian patients after conventional and controlled-release levodopa-carbidopa associations.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Antiparkinson Agents; Blood-Brain Barrier; Carbidopa; Delayed-Action Preparations; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
Does tolerance develop to levodopa? Comparison of 2- and 21-H levodopa infusions.
Topics: Aged; Carbidopa; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Tolerance; Dyskinesia, Drug-Induced; Female; Humans; Infusions, Intravenous; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Tyrosine | 1993 |
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Electrocardiography; Half-Life; Homovanillic Acid; Humans; Levodopa; Male; Nitriles; Reference Values; Tyrosine | 1993 |
Effects of 3-O-methyl on L-dopa-facilitated synthesis and efflux of dopamine from rat striatal slices.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antiparkinson Agents; Cerebrospinal Fluid; Corpus Striatum; Dopamine; Drug Interactions; Levodopa; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Tyrosine | 1995 |
Oxidative damage caused by free radicals produced during catecholamine autoxidation: protective effects of O-methylation and melatonin.
Topics: Catecholamines; Copper Sulfate; Deoxyepinephrine; Dopamine; Free Radicals; Levodopa; Melatonin; Methylation; Oxidation-Reduction; Phycoerythrin; Spectrometry, Fluorescence; Tyrosine | 1996 |
Tyrosine and tryptophan derivatives in pig lumbar cerebrospinal fluid. Effects of subchronic administration of dopa associated with benserazide.
Topics: 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Benserazide; Drug Interactions; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Kynurenine; Levodopa; Male; Methoxyhydroxyphenylglycol; Normetanephrine; Swine; Tryptamines; Tryptophan; Tyrosine | 1996 |
An in vivo comparison of the capacity of striatal versus extrastriatal brain regions to form dopamine from exogenously administered L-dopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biotransformation; Brain Chemistry; Cerebellum; Dopamine; Dopamine Agents; Extracellular Space; Hydroxyindoleacetic Acid; Levodopa; Male; Microdialysis; Neostriatum; Occipital Lobe; Rats; Rats, Sprague-Dawley; Tyrosine | 1996 |
Simultaneous determination of L-dopa and 3-O-methyldopa in human platelets and plasma using high-performance liquid chromatography with electrochemical detection.
Topics: Adult; Aged; Antiparkinson Agents; Blood Platelets; Chromatography, High Pressure Liquid; Electrochemistry; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1997 |
Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease.
Topics: Aged; Analysis of Variance; Antiparkinson Agents; Biomarkers; Catecholamines; Female; Hallucinations; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Isoquinolines; Levodopa; Male; Parkinson Disease; Reference Values; Regression Analysis; Tyrosine | 1996 |
A comparative study on neurochemistry of cerebrospinal fluid in advanced Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Progression; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 1999 |
Acute overdosage and intoxication with carbidopa/levodopa can be detected in the subacute stage by measurement of 3-o-methyldopa.
Topics: Aged; Carbidopa; Dose-Response Relationship, Drug; Drug Combinations; Drug Overdose; Humans; Levodopa; Male; Time Factors; Tyrosine | 1999 |
Interaction between L-DOPA and 3-O-methyl-L-DOPA for transport in immortalised rat capillary cerebral endothelial cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; beta-Alanine; Biological Transport; Cells, Cultured; Cerebellum; Dopamine Agents; Drug Interactions; Endothelium, Vascular; Levodopa; Rats; Tyrosine | 1999 |
Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons.
Topics: Animals; Benzophenones; Catechol O-Methyltransferase Inhibitors; Cell Survival; Cells, Cultured; Dopamine; Dopamine Agents; Enzyme Inhibitors; Levodopa; Mesencephalon; Neurons; Rats; S-Adenosylmethionine; Tyrosine | 2000 |
The effects of central aromatic amino acid DOPA decarboxylase inhibition on the motor actions of L-DOPA and dopamine agonists in MPTP-treated primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Callithrix; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hydrazines; Levodopa; Male; Motor Activity; Quinolones; Quinpirole; Thiophenes; Tyrosine | 2000 |
The influence of L-dopa on methylation capacity in aromatic L-amino acid decarboxylase deficiency: biochemical findings in two patients.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypokinesia; Levodopa; Methoxyhydroxyphenylglycol; Methylation; Muscle Hypotonia; Tetrahydrofolates; Tyrosine | 2000 |
The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Biogenic Monoamines; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dopamine Antagonists; Drug Combinations; Enzyme Inhibitors; Haloperidol; Homovanillic Acid; Hydrazines; Levodopa; Male; Medial Forebrain Bundle; Oxidopamine; Rats; Rats, Wistar; Stereotyped Behavior; Tyrosine | 2001 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease.
Topics: Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2001 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Methylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2001 |
L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase.
Topics: Animals; Blotting, Western; Brain; Catechol O-Methyltransferase; Dopamine; Enzyme Induction; Kidney; Levodopa; Liver; Male; Methionine Adenosyltransferase; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tyrosine; Up-Regulation | 2001 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
3-OMD and homocysteine plasma levels in parkinsonian patients.
Topics: Dihydroxyphenylalanine; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Tyrosine | 2002 |
Modifications of plasma and platelet levels of L-DOPA and its direct metabolites during treatment with tolcapone or entacapone in patients with Parkinson's disease.
Topics: Age Factors; Age of Onset; Aged; Antiparkinson Agents; Benzophenones; Blood Platelets; Catechols; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Levodopa; Male; Middle Aged; Nitriles; Nitrophenols; Parkinson Disease; Retrospective Studies; Sex Characteristics; Tolcapone; Tyrosine; Up-Regulation | 2003 |
Simultaneous determination of levodopa and 3-O-methyldopa in human plasma by liquid chromatography with electrochemical detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Levodopa; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tyrosine | 2004 |
Behavioral and neurochemical effects of noradrenergic depletions with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Basal Ganglia; Behavior, Animal; Benzylamines; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Dopamine Agents; Homovanillic Acid; Levodopa; Locus Coeruleus; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; Serotonin; Statistics, Nonparametric; Tyrosine | 2004 |
Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid.
Topics: 3,4-Dihydroxyphenylacetic Acid; Calibration; Carbidopa; Chromatography, High Pressure Liquid; Dopamine; Electrochemistry; Levodopa; Tyrosine | 2006 |
The role of 3-O-methyldopa in the side effects of L-dopa.
Topics: Animals; Antiparkinson Agents; Benzazepines; Brain Chemistry; Catecholamines; Cell Survival; Chromatography, High Pressure Liquid; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Levodopa; Male; Membrane Potentials; Mitochondrial Membranes; Motor Activity; PC12 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Dopamine D1; Synaptic Transmission; Tyrosine | 2008 |
Peripheral COMT inhibition prevents levodopa associated homocysteine increase.
Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Delayed-Action Preparations; Dihydroxyphenylalanine; Enzyme Inhibitors; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Nitriles; Parkinson Disease; Time Factors; Tyrosine | 2009 |
Caffeic acid improves the bioavailability of L-dopa in rabbit plasma.
Topics: Animals; Caffeic Acids; Carbidopa; Coumaric Acids; Levodopa; Rabbits; Tyrosine | 2010 |
Cysteinyl-glycine reduction as marker for levodopa-induced oxidative stress in Parkinson's disease patients.
Topics: Analysis of Variance; Antiparkinson Agents; Carbidopa; Dipeptides; Female; Humans; Levodopa; Male; Oxidative Stress; Parkinson Disease; Tyrosine | 2011 |
Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).
Topics: Base Sequence; Child; Codon, Nonsense; Congenital Abnormalities; Congenital Microtia; Dihydroxyphenylalanine; DNA Primers; Ear; Ear, Inner; Electroencephalography; Epilepsy; Fibroblast Growth Factor 3; Folate Receptor 1; Folic Acid Deficiency; Humans; Levodopa; Male; Molecular Sequence Data; Pyridoxal Phosphate; Radiography; Sequence Analysis, DNA; Skull; Syndrome; Tooth Abnormalities; Tyrosine | 2011 |
Relationship between 3-O-methyldopa and the clinical effects of entacapone in advanced Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Biomarkers; Carbidopa; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Disease Progression; Dopa Decarboxylase; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Japan; Levodopa; Male; Middle Aged; Motor Activity; Nitriles; Parkinson Disease; Prospective Studies; Treatment Outcome; Tyrosine | 2011 |
Effects of 3-O-methyldopa, L-3,4-dihydroxyphenylalanine metabolite, on locomotor activity and dopamine turnover in rats.
Topics: Animals; Antiparkinson Agents; Brain; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Motor Activity; Parkinson Disease; Rats; Rats, Wistar; Tyrosine | 2012 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
Pharmacokinetics of levodopa, carbidopa, and 3-O-methyldopa following 16-hour jejunal infusion of levodopa-carbidopa intestinal gel in advanced Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Biotransformation; Carbidopa; Chemistry, Pharmaceutical; Drug Combinations; Female; Gels; Germany; Humans; Infusion Pumps; Intestinal Absorption; Intubation, Gastrointestinal; Jejunum; Levodopa; Male; Middle Aged; Parkinson Disease; Sweden; Tyrosine | 2013 |
Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Topics: Benzophenones; Blood Chemical Analysis; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Nitriles; Nitrophenols; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Tolcapone; Tyrosine | 2015 |
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
Topics: Animals; Benzofurans; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Kinetics; Levodopa; Male; Metabolome; Methylation; Nitrophenols; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Substrate Specificity; Tolcapone; Tyrosine | 2015 |
Simultaneous estimation of levodopa, carbidopa and 3-oxymethyldopa in rat plasma using HPLC-ECD.
Topics: Animals; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Electrochemical Techniques; Levodopa; Limit of Detection; Male; Rats; Rats, Wistar; Tyrosine | 2016 |
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA.
Topics: Animals; Astrocytes; Catechol O-Methyltransferase Inhibitors; Catechols; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Glutathione; Levodopa; Mesencephalon; Neuroprotection; Neuroprotective Agents; Nitriles; Rats, Sprague-Dawley; Tyrosine | 2016 |
Levodopa, placebo and rotigotine change biomarker levels for oxidative stress.
Topics: Aged; Analysis of Variance; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dipeptides; Dopamine Agents; Electrochemical Techniques; Female; Homocysteine; Humans; Levodopa; Male; Middle Aged; Oxidative Stress; Parkinson Disease; Tetrahydronaphthalenes; Thiophenes; Time Factors; Tyrosine | 2017 |
Detection of 3-O-methyldopa in dried blood spots for neonatal diagnosis of aromatic L-amino-acid decarboxylase deficiency: The northeastern Italian experience.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Female; Humans; Infant, Newborn; Italy; Levodopa; Male; Neonatal Screening; Neurotransmitter Agents; Tandem Mass Spectrometry; Tyrosine | 2021 |
Effect of catechin and commercial preparation of green tea essence on the pharmacokinetics of l-dopa in rabbits.
Topics: Animals; Biological Availability; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, Liquid; Herb-Drug Interactions; Levodopa; Male; Rabbits; Reproducibility of Results; Tandem Mass Spectrometry; Tea; Tyrosine | 2021 |
3-Methoxytyrosine as an indicator of dopaminergic manipulation in equine plasma.
Topics: Animals; Carbidopa; Catechol O-Methyltransferase; Catechols; Dopamine; Horses; Levodopa | 2023 |
Discovery of non-proteinogenic amino acids inhibiting biofilm formation by S. aureus and methicillin-resistant S. aureus.
Topics: Amino Acids; Anti-Bacterial Agents; Biofilms; Dose-Response Relationship, Drug; Drug Discovery; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus; Structure-Activity Relationship | 2021 |