3-methoxymorphinan has been researched along with dextrorphan in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bochner, F; Chen, ZR; Somogyi, AA | 1 |
| Bochner, F; Kerry, NL; Mikus, G; Somogyi, AA | 1 |
| Granda, BW; Grassi, JM; Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; Venkatakrishnan, K; von Moltke, LL | 1 |
| Kristensen, HT | 1 |
| Abdel-Rahman, SM; Gotschall, RR; Kauffman, RE; Kearns, GL; Leeder, JS | 1 |
| Unadkat, JD; Wang, Y | 1 |
| Bendriss, EK; Markoglou, N; Wainer, IW | 1 |
| Haining, RL; Yu, A | 1 |
| Arellano, C; Dane à Yakan, EN; Houin, G; Lacombe, O; Philibert, C; Vachoux, C; Woodley, J | 1 |
| Chen, YW; Hou, CH; Lin, CN; Lin, MT; Tu, CH; Tzeng, JI; Wang, JJ | 1 |
| Chen, YC; Chen, YW; Chu, CC; Kao, CH; Lin, CN; Lin, MT; Wang, JJ | 1 |
| Chen, CH; Chen, HH; Ho, HO; Lin, SY; Sheu, MT | 1 |
| Mironidou-Tzouveleki, M; Niopas, I; Spanakis, M; Vizirianakis, IS | 1 |
| Abbas, FA; Al-Jenoobi, FI; Al-Mohizea, AM; Al-Suwayeh, SA; Al-Thukair, AA; Alkharfy, KM; Ansari, MJ; Jamil, S | 1 |
| de Bruijn, P; de Graan, AJ; Lam, MH; Loos, WJ; Mathijssen, RH; van Fessem, MA; van Schaik, RH; Wiemer, EA | 1 |
| Abbas, FA; Al-Jenoobi, FI; Al-Mohizea, AM; Al-Suwayeh, SA; Al-Thukair, AA; Alam, MA; Alkharfy, KM | 1 |
| Aklillu, E; Beck, O; Bedada, W; Bertilsson, L; de Andrés, F; Engidawork, E; Llerena, A; Pohanka, A | 1 |
| Roberts, A; Watson, AR | 1 |
| Cornthwaite, HM; McDonald, CS; Watterson, JH | 1 |
| Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B | 1 |
3 trial(s) available for 3-methoxymorphinan and dextrorphan
| Article | Year |
|---|---|
Investigation of terbinafine as a CYP2D6 inhibitor in vivo.
Topics: Adult; Antifungal Agents; Antitussive Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Female; Humans; Male; Naphthalenes; Phenotype; Prospective Studies; Reference Values; Terbinafine; Volunteers | 1999 |
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Humans; Male; Microsomes, Liver; Nigella sativa; Plant Extracts; Seeds; Young Adult | 2010 |
Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects.
Topics: Adolescent; Adult; Biotransformation; Curcuma; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Dealkylation; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Ethanol; Healthy Volunteers; Herb-Drug Interactions; Humans; Linear Models; Liver; Male; Microsomes, Liver; Phytotherapy; Plant Extracts; Plants, Medicinal; Powders; Rhizome; Saudi Arabia; Solvents; Substrate Specificity; Young Adult | 2015 |
17 other study(ies) available for 3-methoxymorphinan and dextrorphan
| Article | Year |
|---|---|
Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man.
Topics: Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Glucuronidase; Humans; Levorphanol | 1990 |
The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
Topics: Autoantibodies; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextropropoxyphene; Dextrorphan; Humans; In Vitro Techniques; Methadone; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Perhexiline; Phenotype; Quinidine | 1994 |
Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.
Topics: Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Quinidine; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Transfection | 1998 |
Simultaneous determination of dextromethorphan and its metabolites in human plasma by capillary electrophoresis.
Topics: Administration, Cutaneous; Administration, Oral; Dextromethorphan; Dextrorphan; Electrophoresis, Capillary; Excitatory Amino Acid Antagonists; Humans; Models, Chemical; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1998 |
Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes.
Topics: Antibodies, Blocking; Antitussive Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases | 1999 |
High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations.
Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; HIV Infections; Humans; Malaria; Microsomes, Liver; Models, Chemical; Oxidoreductases, N-Demethylating; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?
Topics: Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases, N-Demethylating | 2001 |
Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats.
Topics: Anesthetics, Local; Animals; Area Under Curve; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Lidocaine; Male; Nerve Block; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Time Factors | 2006 |
The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Bupivacaine; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Male; Motor Activity; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection.
Topics: Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors | 2007 |
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study.
Topics: Antitussive Agents; Calibration; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Dextrorphan; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry.
Topics: Chromatography, Liquid; Dextromethorphan; Dextrorphan; Humans; Mass Spectrometry; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Time Factors | 2011 |
The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.
Topics: Adult; Catha; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; Ethiopia; Excitatory Amino Acid Antagonists; Humans; Male; Plant Leaves; Young Adult | 2015 |
Identifying Levorphanol Ingestion Using Urine Biomarkers in Health Care Patients.
Topics: Biomarkers; Chromatography, Liquid; Dextromethorphan; Dextrorphan; Female; Humans; Levorphanol; Male; Retrospective Studies; Substance Abuse Detection | 2018 |
Analysis of Dextromethorphan and Three Metabolites in Decomposed Skeletal Tissues by UPLC-QToF-MS: Comparison of Acute and Repeated Drug Exposures.
Topics: Animals; Body Remains; Bone and Bones; Chromatography, Liquid; Dextromethorphan; Dextrorphan; Mass Spectrometry; Rats | 2019 |
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1.
Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation | 2019 |