3-methoxymorphinan and dextromethorphan

3-methoxymorphinan has been researched along with dextromethorphan in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.23)	18.7374
1990's	11 (35.48)	18.2507
2000's	12 (38.71)	29.6817
2010's	7 (22.58)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bochner, F; Chen, ZR; Somogyi, AA	1
Peet, NP	1
Bochner, F; Kerry, NL; Mikus, G; Somogyi, AA	2
Gorski, JC; Haehner, BD; Hall, SD; Jones, DR; O'Mara, EM	1
Fogelman, SM; Greenblatt, DJ; Schmider, J; Shader, RI; von Moltke, LL	1
Granda, BW; Grassi, JM; Greenblatt, DJ; Harmatz, JS; Schmider, J; Shader, RI; Venkatakrishnan, K; von Moltke, LL	1
Kristensen, HT	1
Abdel-Rahman, SM; Gotschall, RR; Kauffman, RE; Kearns, GL; Leeder, JS	1
Fleckenstein, LL; Ku, YM; Min, DI; Vichiendilokkul, A	1
Unadkat, JD; Wang, Y	1
Bertino, JS; Gaedigk, A; Gotschall, R; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN	1
Gillenwater, HH; Hamilton, G; Hawke, RL; LeCluyse, EL; Lindley, C; McCune, JS; Ritchie, J	1
Bendriss, EK; Markoglou, N; Wainer, IW	1
Haining, RL; Yu, A	1
Jhoo, JH; Jhoo, WK; Kim, HC; Kim, WK; Ko, KH; Lee, PH; Lee, YH; Seo, DO; Shin, CY; Shin, EJ	1
Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF	1
Chen, TS; Hsiong, CH; Hu, OY; Hung, CF; Kuo, BP; Pao, LH	1
Arellano, C; Dane à Yakan, EN; Houin, G; Lacombe, O; Philibert, C; Vachoux, C; Woodley, J	1
Chen, YW; Hou, CH; Lin, CN; Lin, MT; Tu, CH; Tzeng, JI; Wang, JJ	1
Chen, YC; Chen, YW; Chu, CC; Kao, CH; Lin, CN; Lin, MT; Wang, JJ	1
Chen, CH; Chen, HH; Ho, HO; Lin, SY; Sheu, MT	1
Cheng, PY; Chiu, MC; Jiau, SS; Lee, YM; Tsai, WH; Wu, ES; Yen, MH	1
Mironidou-Tzouveleki, M; Niopas, I; Spanakis, M; Vizirianakis, IS	1
Abbas, FA; Al-Jenoobi, FI; Al-Mohizea, AM; Al-Suwayeh, SA; Al-Thukair, AA; Alkharfy, KM; Ansari, MJ; Jamil, S	1
de Bruijn, P; de Graan, AJ; Lam, MH; Loos, WJ; Mathijssen, RH; van Fessem, MA; van Schaik, RH; Wiemer, EA	1
Abbas, FA; Al-Jenoobi, FI; Al-Mohizea, AM; Al-Suwayeh, SA; Al-Thukair, AA; Alam, MA; Alkharfy, KM	1
Aklillu, E; Beck, O; Bedada, W; Bertilsson, L; de Andrés, F; Engidawork, E; Llerena, A; Pohanka, A	1
Roberts, A; Watson, AR	1
Cornthwaite, HM; McDonald, CS; Watterson, JH	1
Brockmöller, J; Friesacher, HR; Meyer, MJ; Neumann, VE; Tzvetkov, MV; Zdrazil, B	1

Trials

7 trial(s) available for 3-methoxymorphinan and dextromethorphan

Article	Year
Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation. Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Antitussive Agents; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Erythromycin; Female; Humans; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenotype; Rifampin	1996
Investigation of terbinafine as a CYP2D6 inhibitor in vivo. Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:5 Topics: Adult; Antifungal Agents; Antitussive Agents; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Female; Humans; Male; Naphthalenes; Phenotype; Prospective Studies; Reference Values; Terbinafine; Volunteers	1999
A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers. Pharmacotherapy, 1999, Volume: 19, Issue:6 Topics: Administration, Oral; Adult; Antitussive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Emulsions; Female; Humans; Immunosuppressive Agents; Injections, Intravenous; Male; Metabolic Clearance Rate; Oxidoreductases, N-Demethylating; Predictive Value of Tests; Reference Values	1999
In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:4 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Breath Tests; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dextromethorphan; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Induction; Erythromycin; Female; Glucocorticoids; Hepatocytes; Humans; Hydroxylation; In Vitro Techniques; Male; Mixed Function Oxygenases; Predictive Value of Tests; Reference Values; Testosterone	2000
Single-point plasma or urine dextromethorphan method for determining CYP3A activity. Biopharmaceutics & drug disposition, 2003, Volume: 24, Issue:9 Topics: Administration, Oral; Adult; Antitussive Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Delayed-Action Preparations; Dextromethorphan; Humans; Male; Metabolic Clearance Rate; Oxidoreductases, N-Demethylating; Phenotype; Saliva	2003
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects. Drug metabolism letters, 2010, Volume: 4, Issue:1 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Humans; Male; Microsomes, Liver; Nigella sativa; Plant Extracts; Seeds; Young Adult	2010
Effect of Curcuma longa on CYP2D6- and CYP3A4-mediated metabolism of dextromethorphan in human liver microsomes and healthy human subjects. European journal of drug metabolism and pharmacokinetics, 2015, Volume: 40, Issue:1 Topics: Adolescent; Adult; Biotransformation; Curcuma; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Dealkylation; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Ethanol; Healthy Volunteers; Herb-Drug Interactions; Humans; Linear Models; Liver; Male; Microsomes, Liver; Phytotherapy; Plant Extracts; Plants, Medicinal; Powders; Rhizome; Saudi Arabia; Solvents; Substrate Specificity; Young Adult	2015

Other Studies

24 other study(ies) available for 3-methoxymorphinan and dextromethorphan

Article	Year
Simultaneous determination of dextromethorphan and three metabolites in plasma and urine using high-performance liquid chromatography with application to their disposition in man. Therapeutic drug monitoring, 1990, Volume: 12, Issue:1 Topics: Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Glucuronidase; Humans; Levorphanol	1990
N-Demethylation of dextromethorphan. Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:12 Topics: Dealkylation; Dextromethorphan; Levorphanol	1980
The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes. British journal of clinical pharmacology, 1994, Volume: 38, Issue:3 Topics: Autoantibodies; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextropropoxyphene; Dextrorphan; Humans; In Vitro Techniques; Methadone; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Perhexiline; Phenotype; Quinidine	1994
Primary and secondary oxidative metabolism of dextromethorphan. In vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes. Biochemical pharmacology, 1993, Feb-24, Volume: 45, Issue:4 Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Isoenzymes; Kinetics; Methylation; Microsomes, Liver; Oxidation-Reduction; Phenotype; Rats; Rats, Sprague-Dawley	1993
Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1. Biopharmaceutics & drug disposition, 1997, Volume: 18, Issue:3 Topics: Animals; Antitussive Agents; Benzoflavones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Ditiocarb; Enzyme Inhibitors; Humans; In Vitro Techniques; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Quinidine; Rats; Sulfaphenazole; Tissue Donors	1997
Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:9 Topics: Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Quinidine; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Sulfaphenazole; Transfection	1998
Simultaneous determination of dextromethorphan and its metabolites in human plasma by capillary electrophoresis. Journal of pharmaceutical and biomedical analysis, 1998, Volume: 18, Issue:4-5 Topics: Administration, Cutaneous; Administration, Oral; Dextromethorphan; Dextrorphan; Electrophoresis, Capillary; Excitatory Amino Acid Antagonists; Humans; Models, Chemical; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet	1998
Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes. Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:7 Topics: Antibodies, Blocking; Antitussive Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Dextromethorphan; Dextrorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases	1999
Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity. Pharmacogenetics, 1999, Volume: 9, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Female; Genotype; Humans; Male; Methylation; Oxidoreductases, N-Demethylating; Phenotype	1999
High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. Journal of chromatography. B, Biomedical sciences and applications, 2001, Apr-15, Volume: 754, Issue:1 Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; HIV Infections; Humans; Malaria; Microsomes, Liver; Models, Chemical; Oxidoreductases, N-Demethylating; Reproducibility of Results; Sensitivity and Specificity	2001
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:11 Topics: Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextrorphan; Humans; Isoenzymes; Microsomes, Liver; Oxidoreductases, N-Demethylating	2001
New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. Life sciences, 2003, Mar-07, Volume: 72, Issue:16 Topics: Animals; Anticonvulsants; Dextromethorphan; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Morphinans; Radioligand Assay; Receptors, sigma; Seizures	2003
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. Xenobiotica; the fate of foreign compounds in biological systems, 2003, Volume: 33, Issue:3 Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin	2003
Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, May-05, Volume: 819, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Male; Mass Spectrometry; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity	2005
Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats. European journal of pharmacology, 2006, Aug-21, Volume: 544, Issue:1-3 Topics: Anesthetics, Local; Animals; Area Under Curve; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Lidocaine; Male; Nerve Block; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Time Factors	2006
The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan. European journal of pharmacology, 2007, Aug-27, Volume: 569, Issue:3 Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Bupivacaine; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Male; Motor Activity; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors	2007
Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Nov-01, Volume: 859, Issue:1 Topics: Chromatography, High Pressure Liquid; Dextromethorphan; Dextrorphan; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors	2007
Anti-inflammatory effects of LK-3, on LPS-induced sepsis in rats. The Chinese journal of physiology, 2008, Oct-31, Volume: 51, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Dextromethorphan; Endotoxemia; Heart Rate; Lipopolysaccharides; Liver; Lung; Male; Neutrophils; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Inbred WKY; Superoxides; Tumor Necrosis Factor-alpha; Vasoconstriction; Vasodilation	2008
A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study. Biomedical chromatography : BMC, 2009, Volume: 23, Issue:11 Topics: Antitussive Agents; Calibration; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Dextrorphan; Gas Chromatography-Mass Spectrometry; Humans; Reproducibility of Results; Sensitivity and Specificity	2009
Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2011, Jan-25, Volume: 54, Issue:2 Topics: Chromatography, Liquid; Dextromethorphan; Dextrorphan; Humans; Mass Spectrometry; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Time Factors	2011
The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans. Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:6 Topics: Adult; Catha; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Dextromethorphan; Dextrorphan; Ethiopia; Excitatory Amino Acid Antagonists; Humans; Male; Plant Leaves; Young Adult	2015
Identifying Levorphanol Ingestion Using Urine Biomarkers in Health Care Patients. Pain physician, 2018, Volume: 21, Issue:2 Topics: Biomarkers; Chromatography, Liquid; Dextromethorphan; Dextrorphan; Female; Humans; Levorphanol; Male; Retrospective Studies; Substance Abuse Detection	2018
Analysis of Dextromethorphan and Three Metabolites in Decomposed Skeletal Tissues by UPLC-QToF-MS: Comparison of Acute and Repeated Drug Exposures. Journal of analytical toxicology, 2019, Oct-17, Volume: 43, Issue:9 Topics: Animals; Body Remains; Bone and Bones; Chromatography, Liquid; Dextromethorphan; Dextrorphan; Mass Spectrometry; Rats	2019
Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1. Journal of medicinal chemistry, 2019, 11-14, Volume: 62, Issue:21 Topics: Analgesics, Opioid; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Organic Cation Transporter 1; Permeability; Protein Conformation	2019