3-mercaptopyruvic acid and cysteine

3-mercaptopyruvic acid has been researched along with cysteine in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199023 (35.94)18.7374
1990's8 (12.50)18.2507
2000's8 (12.50)29.6817
2010's23 (35.94)24.3611
2020's2 (3.13)2.80

Authors

AuthorsStudies
Baskin, SI; Wing, DA1
Davis, RH; Mousa, HM1
Hattori, K; Okamoto, A; Ozawa, N; Tateishi, M; Tomisawa, H; Uda, F1
Kinuta, M; Masuoka, N; Ohta, J; Ubuka, T; Yao, K; Yuasa, S1
Ohta, J; Ubuka, T1
Brockway, RA; Nakatani, M; Paglia, DE; Toohey, JI; Valentine, WN1
Sörbo, B1
Anderson, M; Scholtz, JM; Schuster, SM1
Mårtensson, J; Nilsson, L; Sörbo, B1
Akagi, R; Kiguchi, S; Mikami, H; Taniguchi, M; Ubuka, T1
Toohey, JI1
Kiguchi, S1
Gumińska, M; Kedryna, T; Marchut, E1
Hannestad, U; Mårtensson, J; Sjödahl, R; Sörbo, B1
Jarabak, R1
Cooper, AJ; Haber, MT; Meister, A1
Cavallini, D; Colosimo, A; Costa, M; Pensa, B1
Nagahara, N; Nishino, T; Okazaki, T1
Kozarich, JW; Magliozzo, RS; Parast, CV; Peisach, J; Wong, KK1
Clonis, YD; Labrou, NE1
Huang, J; Khan, S; O'Brien, PJ1
Papenbrock, J; Schmidt, A1
Abe, T; Ubuka, T; Wróbel, M; Yao, WB1
Cassinelli, G; Colnaghi, R; Drummond, M; Forlani, F; Pagani, S1
FRASER, PE; MEISTER, A; TICE, SV1
KUN, E1
CLEMEDSON, CJ; FREDRIKSSON, T; HANSEN, B; HULTMAN, H; SORBO, B1
FANSHIER, DW; KUN, E5
FANSHIER, DW; KLAUSNER, C; KUN, E1
KUN, E; WILLIAMS-ASHMAN, HG1
Acosta, M; Beard, S; Jerez, CA; Mobarec, JC; Ponce, J; Vera, M1
Nagahara, N; Sawada, N1
Crankshaw, DL; Goon, DJ; Nagasawa, HT; Patterson, SE; Vince, R1
Coombs, GH; Georg, I; Westrop, GD1
Kannampuzha, JV; Pritzker, KP; Tupy, JH1
Bigby, TD; Boss, GR; Brenner, M; Briggs, JE; Chan, A; Crankshaw, DL; Kozocas, JA; Mahon, SB; Monteil, A; Nagasawa, HT; Patterson, SE; Pilz, RB1
Geng, B; Ouyang, JP; Ren, YS; Tang, CS; Wang, XJ; Wu, SY; Yu, F; Zhao, J1
Beebe, DS; Belani, KG; George, P; Nagasawa, HT; Patterson, SE; Singh, H; Vince, R1
Coletta, C; Erdélyi, K; Módis, K; Papapetropoulos, A; Szabo, C1
Cohen, JF; Crankshaw, DL; Monteil, AR; Nagasawa, HT; Patterson, SE; Vince, R1
Asimakopoulou, A; Coletta, C; Módis, K; Papapetropoulos, A; Szabo, C1
Banerjee, R; Chiku, T; Koutmos, M; Yadav, PK; Yamada, K1
Hirokawa, T; Ishii, K; Koike, S; Matsushima, K; Ogasawara, Y; Shibuya, N; Tanabe, S1
Logue, BA; Mitchell, BL; Monteil, AR; Patterson, SE; Stutelberg, MW; Vinnakota, CV1
Ahmad, A; Brunyánszki, A; Coletta, C; Módis, K; Oláh, G; Papapetropoulos, A; Rios, EC; Szabo, C; Szczesny, B; Yanagi, K1
Aaronson, PI; Prieto-Lloret, J1
Kimura, H; Kimura, Y; Koike, S; Lefer, D; Nagahara, N; Ogasawara, Y; Shibuya, N; Toyofuku, Y1
Boss, GR; Dzisam, JK; Logue, BA; Monteil, AR; Patterson, SE; Petrikovics, I; Rockwood, GA; Stutelberg, MW1
Liu, JH; Wang, SG; Wang, T; Yang, J; Ye, ZQ; Yin, CP; Zhang, Y1
Braun, HP; Brinkkötter, M; Busch, T; Fernie, AR; Hildebrandt, TM; Höfler, S; Lorenz, C; Tohge, T1
Chen, D; Chen, K; Chen, Q; Guan, G; Hu, H; Li, W; Qiao, M; Qiu, L; Wang, K; Zhao, X; Zhu, J1
Briggs, J; Crankshaw, DL; Logue, BA; Moeller, B; Nagasawa, HT; Patterson, SE; Stutelberg, MW; Vince, R; Vinnakota, CV1
Brandt, U; D'Imprima, E; Kühlbrandt, W; Mills, DJ; Parey, K; Vonck, J; Zickermann, V1
Andreeßen, C; Gerlt, V; Steinbüchel, A1
Calzia, E; Georgieff, M; Gröger, M; Hafner, S; Hartmann, C; Huber-Lang, M; Kress, S; Lukaschewski, B; McCook, O; Merz, T; Nagahara, N; Radermacher, P; Szabó, C; Wachter, U; Wepler, M1
Hirai, H; Hisatsune, A; Katsuki, H; Konno, A; Kurauchi, Y; Sato, M; Seki, T1
Shibuya, N1
Balan, A; Cambui, CCN; Fessel, MR; Meza, AN; Moreno, ACR1
Panagaki, T; Randi, EB; Szabo, C1
Dick, TP; Pedre, B1

Reviews

3 review(s) available for 3-mercaptopyruvic acid and cysteine

ArticleYear
The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase.
    Current medicinal chemistry, 2006, Volume: 13, Issue:10

    Topics: Animals; Cysteine; Disease; Humans; Oxidative Stress; Signal Transduction; Sulfurtransferases

2006
Development of sulfanegen for mass cyanide casualties.
    Annals of the New York Academy of Sciences, 2016, Volume: 1374, Issue:1

    Topics: Animals; Cyanides; Cysteine; Humans; Kinetics; Mass Casualty Incidents; Prodrugs

2016
3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking.
    Biological chemistry, 2021, 02-23, Volume: 402, Issue:3

    Topics: Animals; Cysteine; Humans; Molecular Structure; Sulfur; Sulfurtransferases

2021

Other Studies

61 other study(ies) available for 3-mercaptopyruvic acid and cysteine

ArticleYear
Modifiers of mercaptopyruvate sulfurtransferase catalyzed conversion of cyanide to thiocyanate in vitro.
    Journal of biochemical toxicology, 1992,Summer, Volume: 7, Issue:2

    Topics: Catalysis; Cyanides; Cysteine; Kidney; Phenylpyruvic Acids; Pyruvates; Sulfinic Acids; Sulfurtransferases; Taurine; Thiocyanates; Tissue Extracts

1992
Alternative sulphur donors for detoxification of cyanide in the chicken.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1991, Volume: 99, Issue:3

    Topics: Animals; Antidotes; Chickens; Cyanides; Cysteine; Female; Inactivation, Metabolic; Injections, Intramuscular; Methionine; Sulfites; Sulfur; Thiocyanates; Time Factors

1991
Purification and characterization of 3-mercaptopyruvic acid S-conjugate reductases.
    Biochemical pharmacology, 1990, Nov-01, Volume: 40, Issue:9

    Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Enzyme Stability; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Liver; Male; Molecular Weight; Oxidoreductases; Rats; Rats, Inbred Strains; Substrate Specificity; Tissue Distribution

1990
Formation of sulfate from L-cysteine in rat liver mitochondria.
    Acta medica Okayama, 1990, Volume: 44, Issue:2

    Topics: Animals; Cysteine; Disulfides; Freezing; Glutathione; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Sonication; Sulfates

1990
Reduction of 3-mercaptopyruvate in rat liver is catalyzed by lactate dehydrogenase.
    Acta medica Okayama, 1989, Volume: 43, Issue:2

    Topics: Animals; Chromatography, Affinity; Chromatography, Ion Exchange; Cysteine; Electrophoresis, Polyacrylamide Gel; Immunodiffusion; L-Lactate Dehydrogenase; Liver; Oxidation-Reduction; Rats

1989
Modification of erythrocyte enzyme activities by persulfides and methanethiol: possible regulatory role.
    Proceedings of the National Academy of Sciences of the United States of America, 1987, Volume: 84, Issue:5

    Topics: Cysteine; Cystine; Disulfides; Dithionitrobenzoic Acid; Dithiothreitol; Erythrocytes; Humans; Kinetics; Pyridoxal; Pyruvate Kinase; Sulfhydryl Compounds; Sulfides

1987
3-Mercaptopyruvate, 3-mercaptolactate and mercaptoacetate.
    Methods in enzymology, 1987, Volume: 143

    Topics: Chromatography, Gas; Cysteine; Indicators and Reagents; Sulfhydryl Compounds; Thioglycolates

1987
Rat liver 4-hydroxy-2-ketoglutarate aldolase: purification and kinetic characterization.
    Archives of biochemistry and biophysics, 1985, Volume: 236, Issue:1

    Topics: Animals; Anions; Buffers; Cysteine; Glyoxylates; Liver; Male; Models, Chemical; Molecular Weight; Oxaloacetates; Oxo-Acid-Lyases; Pyruvates; Pyruvic Acid; Rats; Subcellular Fractions

1985
The decarboxylation of 3-mercaptopyruvate to 2-mercaptoacetate.
    FEBS letters, 1984, Oct-29, Volume: 176, Issue:2

    Topics: Animals; Brain; Coenzyme A; Cysteine; Kidney; Liver; Mitochondria; NAD; Octoxynol; Polyethylene Glycols; Rats; Thiamine Pyrophosphate; Thioglycolates

1984
Biosynthesis of S-(2-hydroxy-2-carboxyethylthio)-L-cysteine (3-mercaptolactate-cysteine disulfide) by the rat heart.
    Biochemistry international, 1983, Volume: 6, Issue:2

    Topics: Amino Acids; Animals; Cysteine; Glycine; In Vitro Techniques; Male; Myocardium; Rats; Rats, Inbred Strains

1983
Ketomethylthiobutyric acid formation from methylthioadenosine: a diffusion assay.
    Archives of biochemistry and biophysics, 1983, Volume: 223, Issue:2

    Topics: Adenosine; Animals; Cell Line; Cells, Cultured; Cysteine; Deoxyadenosines; Diffusion; Methionine; Mice; Neoplasms, Experimental; Sulfhydryl Compounds; Thionucleosides

1983
Metabolism of 3-mercaptopyruvate in rat tissues.
    Acta medica Okayama, 1983, Volume: 37, Issue:2

    Topics: Animals; Cysteine; In Vitro Techniques; Kidney; Liver; Male; Myocardium; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sulfhydryl Compounds

1983
The inhibitory effect of L-cysteine and its derivatives on glycolysis in Ehrlich ascites tumour cells.
    Biochimica et biophysica acta, 1983, Aug-17, Volume: 763, Issue:1

    Topics: Aerobiosis; Animals; Carcinoma, Ehrlich Tumor; Cysteine; Glycolysis; Isomerism; Kinetics; Lactates; Lactic Acid; Liver; Mice; Muscles; Organ Specificity

1983
3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family.
    Biochemical medicine, 1981, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Aged; Amino Acid Metabolism, Inborn Errors; Child; Cysteine; Erythrocytes; Female; Humans; Lactates; Male; Middle Aged; Pedigree; Pyruvates; Sulfhydryl Compounds; Sulfurtransferases; Thioglycolates

1981
3-Mercaptopyruvate sulfurtransferase.
    Methods in enzymology, 1981, Volume: 77

    Topics: Animals; Calcium Phosphates; Cattle; Chemical Fractionation; Chromatography; Chromatography, Gel; Copper; Cyanides; Cysteine; Kidney; Methods; Molecular Weight; Spectrophotometry; Sulfurtransferases

1981
On the chemistry and biochemistry of 3-mercaptopyruvic acid, the alpha-keto acid analog of cysteine.
    The Journal of biological chemistry, 1982, Jan-25, Volume: 257, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Catalase; Cattle; Cysteine; Glutamine; Kinetics; L-Lactate Dehydrogenase; Myocardium; Oxidation-Reduction; Spectrophotometry, Infrared; Substrate Specificity; Transaminases

1982
Reduction of beta-thiopyruvic acid by lactate dehydrogenase: a kinetic study.
    Molecular and cellular biochemistry, 1982, Apr-30, Volume: 44, Issue:2

    Topics: Binding, Competitive; Cysteine; Hydrogen-Ion Concentration; Kinetics; L-Lactate Dehydrogenase; NAD; Sulfhydryl Compounds

1982
Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mut
    The Journal of biological chemistry, 1995, Jul-07, Volume: 270, Issue:27

    Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Biological Evolution; Blotting, Western; Cysteine; Cytosol; Liver; Male; Mitochondria; Molecular Sequence Data; Mutagenesis; Rats; Rats, Wistar; Recombinant Proteins; Sequence Analysis; Sequence Homology, Amino Acid; Species Specificity; Structure-Activity Relationship; Sulfurtransferases; Thiosulfate Sulfurtransferase

1995
Electron paramagnetic resonance evidence for a cysteine-based radical in pyruvate formate-lyase inactivated with mercaptopyruvate.
    Biochemistry, 1995, May-02, Volume: 34, Issue:17

    Topics: Acetyltransferases; Binding Sites; Cysteine; Deuterium; Disulfides; Electron Spin Resonance Spectroscopy; Escherichia coli; Free Radicals; Kinetics; Recombinant Proteins; Sulfhydryl Compounds

1995
Biomimetic dye affinity chromatography for the purification of bovine heart lactate dehydrogenase.
    Journal of chromatography. A, 1995, Dec-01, Volume: 718, Issue:1

    Topics: Animals; Anthraquinones; Cattle; Chromatography, Affinity; Chromatography, Ion Exchange; Coloring Agents; Cysteine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Ligands; Molecular Structure; Myocardium; Sepharose; Triazines

1995
The glutathione dependence of inorganic sulfate formation from L- or D-cysteine in isolated rat hepatocytes.
    Chemico-biological interactions, 1998, Apr-03, Volume: 110, Issue:3

    Topics: Alkynes; Animals; Benzoates; Benzoic Acid; Buthionine Sulfoximine; Cells, Cultured; Cyanides; Cycloserine; Cysteine; Glutathione; Glycine; Kinetics; Liver; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Stereoisomerism; Sulfates; Thiosulfates

1998
Characterization of a sulfurtransferase from Arabidopsis thaliana.
    European journal of biochemistry, 2000, Volume: 267, Issue:1

    Topics: Amino Acid Sequence; Arabidopsis; Blotting, Southern; Chloroplasts; Cloning, Molecular; Cyanides; Cysteine; Expressed Sequence Tags; Genes, Plant; Hydrogen-Ion Concentration; Isoenzymes; Mitochondria; Molecular Sequence Data; Molecular Weight; Phylogeny; Protein Sorting Signals; Recombinant Fusion Proteins; Sequence Alignment; Sequence Deletion; Substrate Specificity; Sulfurtransferases; Thiosulfate Sulfurtransferase; Thiosulfates

2000
Effects of thyroxine on L-cysteine desulfuration in mouse liver.
    Acta medica Okayama, 2000, Volume: 54, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cystathionine gamma-Lyase; Cysteine; Female; Liver; Mice; Sulfurtransferases; Thiosulfate Sulfurtransferase; Thyroxine

2000
Properties of the Escherichia coli rhodanese-like protein SseA: contribution of the active-site residue Ser240 to sulfur donor recognition.
    FEBS letters, 2001, Jul-06, Volume: 500, Issue:3

    Topics: Amino Acid Motifs; Amino Acid Substitution; Bacterial Proteins; Binding Sites; Catalysis; Cysteine; Escherichia coli; Ligands; Mutagenesis, Site-Directed; Spectrometry, Fluorescence; Structure-Activity Relationship; Substrate Specificity; Sulfurtransferases; Thiosulfate Sulfurtransferase; Thiosulfates

2001
Enzymatic desulfuration of beta-mercaptopyruvate to pyruvate.
    The Journal of biological chemistry, 1954, Volume: 206, Issue:2

    Topics: Cysteine; Pyruvates; Pyruvic Acid

1954
The reaction of beta-mercaptopyruvate with lactic dehydrogenase of heart muscle.
    Biochimica et biophysica acta, 1957, Volume: 25, Issue:1

    Topics: Cysteine; Myocardium; Oxidoreductases; Pyruvates

1957
On the toxicity of sodium beta-mercaptopyruvate and its antidotal effect against cyanide.
    Acta physiologica Scandinavica, 1958, Feb-10, Volume: 42, Issue:1

    Topics: Antidotes; Cyanides; Cysteine; Humans; Hydrogen Cyanide; Pyruvates; Sodium; Sodium, Dietary

1958
Isolation and identification of beta-mercaptopyruvate desulfurase.
    Biochimica et biophysica acta, 1958, Volume: 27, Issue:3

    Topics: Biochemical Phenomena; Cysteine; Enzymes; Liver; Pyruvates

1958
Enzymic transfer of sulfur from beta-mercaptopyruvate to cyanide.
    Biochimica et biophysica acta, 1959, Volume: 33, Issue:1

    Topics: Biochemical Phenomena; Cyanides; Cysteine; Humans; Pyruvates; Sulfur; Transferases

1959
Inhibition of beta-mercaptopyruvate transsulfurase by metal chelate compounds.
    Biochimica et biophysica acta, 1961, Mar-18, Volume: 48

    Topics: Antimetabolites; Chelating Agents; Cysteine; Metals; Sulfurtransferases

1961
Properties of beta-mercaptopyruvate transsulfurase chromatographically resolved in the presence of beta-mercaptoethanol.
    Biochimica et biophysica acta, 1962, Apr-09, Volume: 58

    Topics: Chromatography; Cysteine; Enzymes; Mercaptoethanol; Sulfhydryl Compounds; Sulfurtransferases

1962
Isolation and properties of a beta-mercaptopyruvate-cleaving copper enzyme.
    Biochimica et biophysica acta, 1959, Volume: 32

    Topics: Biochemical Phenomena; Copper; Cysteine; Cytokinesis; Galium; Pyruvates; Transferases

1959
The rate of cleavage of beta-mercaptopyruvate by rapidly dividing cells.
    Experientia, 1960, Feb-15, Volume: 16

    Topics: Biochemical Phenomena; Cysteine; Cytokinesis; Pyruvates; Sulfhydryl Compounds

1960
Conversion of beta-mercaptopyruvate to 2-mercaptoethanol by yeast enzymes.
    Experientia, 1962, Jun-15, Volume: 18

    Topics: Cysteine; Enzymes; Mercaptoethanol; Mercaptoethylamines; Pyruvates; Saccharomyces cerevisiae; Yeast, Dried; Yeasts

1962
Identification of putative sulfurtransferase genes in the extremophilic Acidithiobacillus ferrooxidans ATCC 23270 genome: structural and functional characterization of the proteins.
    Omics : a journal of integrative biology, 2005,Spring, Volume: 9, Issue:1

    Topics: Acidithiobacillus; Amino Acid Sequence; Binding Sites; Catalytic Domain; Cell-Free System; Cloning, Molecular; Computational Biology; Crystallography, X-Ray; Cyanides; Cysteine; DNA Primers; Escherichia coli; Genome, Bacterial; Iron-Sulfur Proteins; Models, Genetic; Models, Molecular; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Oxygen; Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Static Electricity; Sulfotransferases; Thiosulfate Sulfurtransferase; Thiosulfates

2005
Novel, orally effective cyanide antidotes.
    Journal of medicinal chemistry, 2007, Dec-27, Volume: 50, Issue:26

    Topics: Administration, Oral; Animals; Antidotes; Crystallography, X-Ray; Cyanides; Cysteine; Mice; Prodrugs; Structure-Activity Relationship

2007
The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide.
    The Journal of biological chemistry, 2009, Nov-27, Volume: 284, Issue:48

    Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cysteine; Electron Transport; Kinetics; Mass Spectrometry; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases; Protozoan Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Sulfhydryl Compounds; Sulfides; Sulfur; Sulfurtransferases; Thioredoxins; Trichomonas vaginalis

2009
Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution.
    The Journal of rheumatology, 2009, Volume: 36, Issue:12

    Topics: Alkaline Phosphatase; Calcium Pyrophosphate; Chondrocalcinosis; Cysteine; Humans; Isoenzymes; Molecular Structure

2009
The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2011, Volume: 49, Issue:5

    Topics: Animals; Antidotes; Cobamides; Cyanides; Cysteine; Disease Models, Animal; Drug Therapy, Combination; Male; Mice; Mice, Inbred C57BL; Prodrugs

2011
Multiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats.
    Chinese medical journal, 2011, Volume: 124, Issue:21

    Topics: Animals; Blotting, Western; Cardenolides; Central Nervous System; Cystathionine beta-Synthase; Cysteine; Hemodynamics; Hydrogen Sulfide; Male; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Saponins; Sodium-Potassium-Exchanging ATPase; Sulfurtransferases

2011
Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium.
    Anesthesia and analgesia, 2012, Volume: 114, Issue:5

    Topics: Animals; Blood Gas Analysis; Blood Pressure; Central Venous Pressure; Cyanides; Cysteine; Heart Rate; Heterocyclic Compounds, 1-Ring; Hydrogen-Ion Concentration; Lactic Acid; Nitroprusside; Pilot Projects; Prodrugs; Pulmonary Artery; Swine; Vasodilator Agents

2012
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:2

    Topics: Animals; Base Sequence; Cell Line; Citric Acid Cycle; Cysteine; Electron Transport; Energy Metabolism; Hydrogen Sulfide; Male; Mice; Mitochondria, Liver; Models, Biological; Oxidative Phosphorylation; Quinone Reductases; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sulfurtransferases

2013
Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Antidotes; Cyanides; Cysteine; Humans; Injections, Intramuscular; Mass Casualty Incidents; Poisoning; Quinolizines; Salts; Sulfur Compounds

2013
Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway.
    Biochemical and biophysical research communications, 2013, Apr-19, Volume: 433, Issue:4

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Cysteine; Electrophoresis, Polyacrylamide Gel; Energy Metabolism; Escherichia coli; Hepatocytes; Hydrogen Peroxide; Hydrogen Sulfide; Mice; Mitochondria; Oxidative Stress; Oxygen; Recombinant Proteins; Sulfurtransferases

2013
Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase.
    The Journal of biological chemistry, 2013, Jul-05, Volume: 288, Issue:27

    Topics: Catalysis; Crystallography, X-Ray; Cysteine; Humans; Hydrogen Sulfide; Kinetics; Models, Chemical; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfurtransferases; Thioredoxins

2013
A novel method for the analysis of 3-mercaptopyruvate using high-performance liquid chromatography with fluorescence detection.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Jul-15, Volume: 931

    Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Cysteine; Ketoglutaric Acids; Liver; Male; Mice; Mice, Inbred C57BL; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Transaminases

2013
Determination of 3-mercaptopyruvate in rabbit plasma by high performance liquid chromatography tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Feb-15, Volume: 949-950

    Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Drug Stability; Limit of Detection; Linear Models; Rabbits; Reproducibility of Results; Tandem Mass Spectrometry

2014
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
    Molecular medicine (Cambridge, Mass.), 2015, Feb-18, Volume: 21

    Topics: Animals; Cell Line; Cyclic GMP-Dependent Protein Kinases; Cysteine; Diabetes Mellitus; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Energy Metabolism; Hydrogen Sulfide; Hyperglycemia; Male; Metabolic Networks and Pathways; Mice; Mitochondria; Neovascularization, Physiologic; Oxygen Consumption; Proto-Oncogene Proteins c-akt; Rats; Sulfurtransferases; Thioctic Acid; Vasodilator Agents

2015
Potentiation of Hypoxic Pulmonary Vasoconstriction by Hydrogen Sulfide Precursors 3-Mercaptopyruvate and D-Cysteine Is Blocked by the Cystathionine γ Lyase Inhibitor Propargylglycine.
    Advances in experimental medicine and biology, 2015, Volume: 860

    Topics: Alkynes; Animals; Catalase; Cell Hypoxia; Cystathionine gamma-Lyase; Cysteine; Glycine; Hydrogen Sulfide; Pulmonary Artery; Rats; Sodium Benzoate; Vasoconstriction

2015
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain.
    Scientific reports, 2015, Oct-06, Volume: 5

    Topics: Animals; Brain; Brain Chemistry; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Cysteine; Escherichia coli; Gene Expression; Hydrogen Sulfide; Mice; Mice, Inbred C57BL; Mice, Knockout; Primary Cell Culture; Recombinant Proteins; Sulfides; Sulfurtransferases; Thiosulfate Sulfurtransferase

2015
Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Jan-01, Volume: 1008

    Topics: Animals; Chromatography, Liquid; Cobamides; Cysteine; Limit of Detection; Swine; Tandem Mass Spectrometry

2016
Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.
    The journal of sexual medicine, 2016, Volume: 13, Issue:3

    Topics: Animals; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Diabetes Mellitus, Experimental; Endothelial Cells; Erectile Dysfunction; Humans; Hydrogen Sulfide; Male; Neural Pathways; Penis; Rats; Rats, Sprague-Dawley

2016
Dealing with the sulfur part of cysteine: four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in Arabidopsis mitochondria.
    Physiologia plantarum, 2016, Volume: 157, Issue:3

    Topics: Amino Acids; Arabidopsis; Arabidopsis Proteins; Cysteine; Dioxygenases; Energy Metabolism; Glutathione; Metabolic Networks and Pathways; Mitochondria; Mutagenesis, Insertional; Pyruvic Acid; Seeds; Sulfhydryl Compounds; Sulfur; Sulfurtransferases; Thiosulfates

2016
Synthesis and characterization of a PAMAM-OH derivative containing an acid-labile β-thiopropionate bond for gene delivery.
    International journal of pharmaceutics, 2016, Jul-25, Volume: 509, Issue:1-2

    Topics: Acids; Animals; Cell Line, Tumor; Cysteine; Dendrimers; DNA; Endocytosis; Female; Folic Acid; Gene Transfer Techniques; Genetic Therapy; Hep G2 Cells; Humans; KB Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Particle Size; Polyethylene Glycols; Transfection

2016
Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism.
    Biochimica et biophysica acta, 2016, Volume: 1857, Issue:12

    Topics: Catalysis; Cryoelectron Microscopy; Cysteine; Electron Transport Complex I; Energy Metabolism; Escherichia coli; Fungal Proteins; Hydrogen Sulfide; Mitochondria; Models, Molecular; Protein Conformation; Structure-Activity Relationship; Sulfur; Sulfur Group Transferases; Yarrowia

2016
Conversion of cysteine to 3-mercaptopyruvic acid by bacterial aminotransferases.
    Enzyme and microbial technology, 2017, Volume: 99

    Topics: Alcaligenaceae; Amino Acid Sequence; Aspartate Aminotransferases; Bacterial Proteins; Cupriavidus necator; Cysteine; Enterobacteriaceae; Escherichia coli; Genes, Bacterial; Industrial Microbiology; Kinetics; Paracoccus denitrificans; Phylogeny; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transaminases

2017
The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock.
    Shock (Augusta, Ga.), 2019, Volume: 51, Issue:4

    Topics: Animals; Cysteine; Disease Models, Animal; Female; Immunohistochemistry; Male; Mice; Mitochondria; Mutation; Shock, Hemorrhagic; Shock, Traumatic; Sulfurtransferases

2019
d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production.
    Molecular and cellular neurosciences, 2018, Volume: 93

    Topics: Animals; Antioxidants; Brain; Cysteine; Hydrogen Sulfide; Neurogenesis; Oxidative Stress; Purkinje Cells; Rats

2018
[Production of H
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2018, Volume: 152, Issue:5

    Topics: Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Humans; Hydrogen Sulfide; Sulfides; Sulfurtransferases

2018
Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells.
    Scientific reports, 2019, 11-14, Volume: 9, Issue:1

    Topics: Animals; Bacterial Proteins; Binding Sites; Cell Line; Cysteine; Dendritic Cells; Kinetics; Macrophages; Mice; Mice, Inbred C57BL; Models, Molecular; Mycobacterium tuberculosis; Protein Binding; Protein Conformation; Substrate Specificity; Sulfurtransferases; Thiosulfates

2019
Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.
    Biomolecules, 2020, 04-23, Volume: 10, Issue:4

    Topics: Cell Proliferation; Child; Child, Preschool; Cysteine; Down Syndrome; Energy Metabolism; Female; Fibroblasts; Humans; Hydrogen Sulfide; Infant; Infant, Newborn; Male; Mitochondria; Oxidative Phosphorylation; Sulfurtransferases

2020