Compounds > 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide
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3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide and spiperone

3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide has been researched along with spiperone in 7 studies

Compound Research Comparison

Studies
(3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)		Trials
(3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)		Recent Studies (post-2010)
(3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)		Studies
(spiperone)		Trials
(spiperone)		Recent Studies (post-2010) (spiperone)
33040332,9441385

Protein Interaction Comparison

ProteinTaxonomy3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide (IC50)spiperone (IC50)
Bile salt export pumpHomo sapiens (human)10
D(2) dopamine receptorHomo sapiens (human)0.0008
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.097
D(4) dopamine receptorHomo sapiens (human)0.0005
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.097
Histamine H1 receptorCavia porcellus (domestic guinea pig)0.097
D(3) dopamine receptorHomo sapiens (human)0.0635
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.097
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0001
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.955

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's4 (57.14)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Billings, J; Kung, HF; Kung, MP; Murphy, RA1
Guo, YZ; Kasliwal, R; Kung, HF; Kung, MP; Mach, RH; Pan, SG1
Billings, J; Chumpradit, S; Kung, HF; Kung, MP; Mach, R1
Bobeldijk, M; Boer, GJ; de Bruin, K; Erdtsieck-Ernste, E; Feenstra, MG; Maas, MA; van Royen, EA; Verhoeff, NP1
Bush, M; Ehrenkaufer, RE; Kung, HF; Luedtke, RR; Mach, RH; Molinoff, PB1
Billings, J; Kung, HF; Kung, MP; Luedtke, RR; Molinoff, PB; Schonwetter, BS1
Billings, JJ; Guo, YZ; Kung, HF; Mach, RH1

Other Studies

7 other study(ies) available for 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide and spiperone

ArticleYear
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Benzofurans; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; Iodine Radioisotopes; Isotope Labeling; Male; Molecular Structure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tissue Distribution

1990
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:5

    Topics: Animals; Benzamides; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Iodine Radioisotopes; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship

1988
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.
    Journal of medicinal chemistry, 1993, Jan-22, Volume: 36, Issue:2

    Topics: Animals; Benzamides; Dopamine Agents; Dopamine D2 Receptor Antagonists; Fluorine Radioisotopes; Iodine Radioisotopes; Macaca fascicularis; Male; Pyrrolidines; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

1993
In vitro and in vivo D2-dopamine receptor binding with [123I]S(-) iodobenzamide ([123I]IBZM) in rat and human brain.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1991, Volume: 18, Issue:8

    Topics: Animals; Benzamides; Binding, Competitive; Brain; Corpus Striatum; Dopamine Antagonists; Female; Haloperidol; Humans; In Vitro Techniques; Iodine Radioisotopes; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine D2; Spiperone; Stereoisomerism

1991
Antibodies with high affinity for spiroperidol--II. Cross reactivity with iodobenzamide and domperidone.
    Molecular immunology, 1990, Volume: 27, Issue:7

    Topics: Animals; Antibodies, Heterophile; Antibody Affinity; Antibody Specificity; Benzamides; Binding, Competitive; Cross Reactions; Domperidone; Haptens; Hybridomas; Mice; Pyrrolidines; Rabbits; Spiperone

1990
Characterization of membrane-bound and soluble D2 receptors in canine caudate using [125I]IBZM.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:1

    Topics: Animals; Benzamides; Binding, Competitive; Caudate Nucleus; Cell Membrane; Cytosol; Dogs; Iodine Radioisotopes; Kinetics; Pyrrolidines; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone

1989
Comparison of in vivo D-2 dopamine receptor binding of IBZM and NMSP in rat brain.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1988, Volume: 15, Issue:2

    Topics: Animals; Benzamides; Brain; Iodine Radioisotopes; Male; Pyrrolidines; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tomography, Emission-Computed; Tritium

1988