3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide and raclopride

3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide has been researched along with raclopride in 12 studies

Compound Research Comparison

Studies (3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)	Trials (3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)	Recent Studies (post-2010) (3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide)	Studies (raclopride)	Trials (raclopride)	Recent Studies (post-2010) (raclopride)
330	40	33	1,802	132	419

Protein Interaction Comparison

Protein	Taxonomy	raclopride (IC50)
D(2) dopamine receptor	Homo sapiens (human)	0.052
D(2) dopamine receptor	Mus musculus (house mouse)	0.032
D(2) dopamine receptor	Rattus norvegicus (Norway rat)	0.0279

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (8.33)	18.7374
1990's	5 (41.67)	18.2507
2000's	5 (41.67)	29.6817
2010's	1 (8.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Billings, J; Kung, HF; Kung, MP; Murphy, RA	1
Guo, YZ; Kasliwal, R; Kung, HF; Kung, MP; Mach, RH; Pan, SG	1
Billings, J; Chumpradit, S; Kung, HF; Kung, MP; Mach, R	1
Amici, L; Baldessarini, RJ; Baldwin, RM; Fu, X; Innis, RB; Kula, NS; Tamagnan, GD	1
Gmeiner, P; Gründer, G; Hübner, H; Piel, M; Rösch, F; Stark, D	1
Antonini, A; Kirsch, CM; Leenders, KL; Oertel, WH; Schwarz, J; Tatsch, K	1
Dresel, SH; Hou, C; Huang, XF; Kung, HF; Kung, MP; Meegalla, SK; Mu, M; Patselas, G; Plössl, K; Saffer, JR	1
Seeman, P; Tallerico, T	1
Huang, Y; Laruelle, M	1
Cremer, M; Kosinski, CM; Langen, KJ; Meyer, PT; Salber, D; Schaefer, WM; Schiefer, J	1
Brittain, C; Bullich, S; Catafau, AM; Gunn, RN; Laruelle, M; Llop, J; Nucci, G; Suarez, M	1
Bullich, S; Catafau, AM; Cot, A; Gallego, J; Gunn, RN; Laruelle, M; Pavía, J; Ros, D; Suárez, M	1

Reviews

1 review(s) available for 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide and raclopride

Article	Year
Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights. The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), 2001, Volume: 45, Issue:2 Topics: Animals; Benzamides; Brain; Dopamine; Humans; Pyrrolidines; Raclopride; Receptors, Dopamine; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon	2001

Article

Year

Vulnerability of positron emission tomography radiotracers to endogenous competition. New insights.

The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), 2001, Volume: 45, Issue:2

Topics: Animals; Benzamides; Brain; Dopamine; Humans; Pyrrolidines; Raclopride; Receptors, Dopamine; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

2001

Trials

1 trial(s) available for 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide and raclopride

Article	Year
Comparison of 123I-IBZM SPECT and 11C-raclopride PET findings in patients with parkinsonism. Nuclear medicine communications, 1994, Volume: 15, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzamides; Carbon Radioisotopes; Humans; Middle Aged; Parkinson Disease; Pyrrolidines; Raclopride; Receptors, Dopamine D2; Regression Analysis; Salicylamides; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon	1994

Article

Year

Comparison of 123I-IBZM SPECT and 11C-raclopride PET findings in patients with parkinsonism.

Nuclear medicine communications, 1994, Volume: 15, Issue:10

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzamides; Carbon Radioisotopes; Humans; Middle Aged; Parkinson Disease; Pyrrolidines; Raclopride; Receptors, Dopamine D2; Regression Analysis; Salicylamides; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

1994

Other Studies

10 other study(ies) available for 3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide and raclopride

Article	Year
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: Animals; Benzofurans; Binding, Competitive; Chemical Phenomena; Chemistry; Corpus Striatum; Iodine Radioisotopes; Isotope Labeling; Male; Molecular Structure; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tissue Distribution	1990
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide. Journal of medicinal chemistry, 1988, Volume: 31, Issue:5 Topics: Animals; Benzamides; Chemical Phenomena; Chemistry; Corpus Striatum; In Vitro Techniques; Iodine Radioisotopes; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship	1988
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. Journal of medicinal chemistry, 1993, Jan-22, Volume: 36, Issue:2 Topics: Animals; Benzamides; Dopamine Agents; Dopamine D2 Receptor Antagonists; Fluorine Radioisotopes; Iodine Radioisotopes; Macaca fascicularis; Male; Pyrrolidines; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon	1993
Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM. Bioorganic & medicinal chemistry letters, 2003, Nov-17, Volume: 13, Issue:22 Topics: Benzamides; Indicators and Reagents; Iodine Radioisotopes; Isotope Labeling; Molecular Structure; Pyrrolidines; Structure-Activity Relationship	2003
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors. Bioorganic & medicinal chemistry, 2007, Nov-01, Volume: 15, Issue:21 Topics: Animals; Benzamides; Cell Line; Iodine Isotopes; Radioligand Assay; Receptors, Dopamine D2; Structure-Activity Relationship	2007
Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1999, Volume: 40, Issue:4 Topics: Animals; Benzamides; Benzofurans; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Iodine Radioisotopes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Organotechnetium Compounds; Papio; Pyrrolidines; Raclopride; Radiopharmaceuticals; Receptors, Dopamine; Salicylamides; Tomography, Emission-Computed, Single-Photon; Tropanes	1999
Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. The American journal of psychiatry, 1999, Volume: 156, Issue:6 Topics: Animals; Antipsychotic Agents; Benzamides; Brain; Carbon Radioisotopes; Cloning, Molecular; Clozapine; Dibenzothiazepines; Dopamine; Dose-Response Relationship, Drug; Humans; Iodine Radioisotopes; Mice; Pyrrolidines; Quetiapine Fumarate; Raclopride; Radionuclide Imaging; Receptors, Dopamine D2; Salicylamides; Spodoptera; Substance Withdrawal Syndrome; Tritium	1999
Comparison of intravenous and intraperitoneal [123I]IBZM injection for dopamine D2 receptor imaging in mice. Nuclear medicine and biology, 2008, Volume: 35, Issue:5 Topics: Animals; Autoradiography; Benzamides; Brain; Brain Chemistry; Dopamine Antagonists; Humans; Injections, Intraperitoneal; Injections, Intravenous; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrrolidines; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Tomography, Emission-Computed, Single-Photon	2008
Within-subject comparison of striatal D2 receptor occupancy measurements using [123I]IBZM SPECT and [11C]Raclopride PET. NeuroImage, 2009, Volume: 46, Issue:2 Topics: Adult; Benzamides; Corpus Striatum; Female; Humans; Male; Positron-Emission Tomography; Pyrrolidines; Raclopride; Radiopharmaceuticals; Receptors, Dopamine D2; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution	2009
Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: comparison to 11C-Raclopride PET. NeuroImage, 2010, May-01, Volume: 50, Issue:4 Topics: Adult; Algorithms; Antipsychotic Agents; Benzamides; Brain; Brain Mapping; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Models, Neurological; Phantoms, Imaging; Positron-Emission Tomography; Pyrrolidines; Raclopride; Receptors, Dopamine D2; Scattering, Radiation; Signal Processing, Computer-Assisted; Tomography, Emission-Computed, Single-Photon	2010