3-hydroxyquinolin-2(1h)-one and sulfuric-acid

3-hydroxyquinolin-2(1h)-one has been researched along with sulfuric-acid* in 1 studies

Other Studies

1 other study(ies) available for 3-hydroxyquinolin-2(1h)-one and sulfuric-acid

ArticleYear
One-pot synthesis of 3-hydroxyquinolin-2(1H)-ones from N-phenylacetoacetamide via PhI(OCOCF3)2-mediated α-hydroxylation and H2SO4-promoted intramolecular cyclization.
    The Journal of organic chemistry, 2013, Jun-07, Volume: 78, Issue:11

    A clean, one-pot synthesis of the biologically important 3-hydroxyquinolin-2(1H)-one compounds has been realized from the readily available N-phenylacetoacetamide derivatives through a PhI(OCOCF3)2-mediated α-hydroxylation and a H2SO4-promoted intramolecular condensation. The hydroxyl group in the generated α-hydroxylated intermediate can be well tolerated in the second H2SO4-promoted cyclization step.

    Topics: Acetanilides; Cyclization; Hydroxylation; Iodobenzenes; Molecular Structure; Quinolones; Sulfuric Acids; Trifluoroacetic Acid

2013