3-hydroxyquinidine has been researched along with quinine in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 11 (35.48) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 8 (25.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dixon, PA; Onyeji, CO; Ugwu, NC | 1 |
| Brookshier, LA; Clawson, DC; Hoyer, GL; Marcus, FI; Nolan, PE | 1 |
| Babalola, CP; Bolaji, OO; Dixon, PA | 1 |
| Advenier, C; Leroyer, R; Pays, M; Varoquaux, O | 1 |
| Bhuwapathanapun, S; Christopher, RK; Duffield, AM; Graham, GG; Liddle, C | 1 |
| Babalola, CP; Bolaji, OO; Dixon, PA; Ogunbona, FA | 1 |
| Coville, PF; Walker, RJ; Wanwimolruk, S; Wong, SM; Zhang, H | 1 |
| Birkett, DJ; Coville, PF; Miners, JO; Walker, RJ; Wanwimolruk, S; Zhang, H | 1 |
| Ishizaki, T; Kawashiro, T; Zhao, XJ | 1 |
| Ericsson, O; Gustafsson, LL; Mirghani, RA | 1 |
| Chalcroft, SC; Coville, PF; Ho, PC; Wanwimolruk, S | 1 |
| Bertilsson, L; Ericsson, O; Gustafsson, LL; Hellgren, U; Mirghani, RA; Westerberg, PA | 1 |
| Cook, J; Ericsson, O; Gustafsson, LL; Mirghani, RA; Yu, P | 1 |
| Jantra, A; Pitisuttithum, P; Pukrittayakamee, S; Wanwimolruk, S; White, NJ; Zhang, H | 1 |
| Cook, JM; Ericsson, O; Gustafsson, LL; Mirghani, RA; Tybring, G; Yasar, U; Zheng, T | 1 |
| Bannon, P; Roy, L; Villeneuve, JP | 1 |
| Paine, MF; Pusek, SN; Wanwimolruk, S; Watkins, PB | 1 |
| Bertilsson, L; Ericsson, O; Gustafsson, LL; Mirghani, RA; Tybring, G | 1 |
| Bertilsson, L; Ericsson, O; Gustafsson, LL; Hellgren, U; Mirghani, RA | 1 |
| Gustafsson, LL; Jansson, A; Mirghani, RA | 1 |
| Cook, JM; Deschamps, JR; Han, D; Srirama Sarma, PV | 1 |
| Abdelrahim, II; Adam, I; Elbashir, MI; Elghazali, G; Gustafsson, LL; Mirghani, RA | 1 |
| Omoruyi, SI; Onyeji, CO; Soyinka, JO | 1 |
| Cook, JM; Omoruyi, SI; Onyeji, CO; Owolabi, AR; Sarma, PV; Soyinka, JO | 1 |
| Aklillu, E; Gustafsson, LL; Mukonzo, JK; Ogwal-Okeng, J; Waako, P | 1 |
| Ahmadi, KR; Heaton, J; Legido-Quigley, C; Rahmioglu, N; Smith, NW | 1 |
| Ahmadi, KR; Clement, G; Gill, R; Heaton, J; Hider, RC; Hodgkiss, D; Ma, Y; Rahmioglu, N; Smith, NW; Surdulescu, G; Zlobecka, K | 1 |
| Ahmadi, KR; Clement, G; Gill, R; Heaton, J; Hodgkiss, D; Rahmioglu, N; Smith, NW; Surdulescu, G; Zlobecka, K | 1 |
| Doumbo, OK; Guirou, EA; Hendrix, CW; Kayentao, K; Nyunt, MM; Parsons, TL; Plowe, CV; Venkatesan, M | 1 |
| Andersson, TB; Bäckström, T; Bertilsson, L; Björkhem-Bergman, L; Bredberg, E; Diczfalusy, U; Nylén, H; Rönquist-Nii, Y | 1 |
| Akanmu, MA; Cook, JM; Igbinoba, SI; Nathaniel, TI; Onyeji, CO; Pullela, SS; Soyinka, JO | 1 |
10 trial(s) available for 3-hydroxyquinidine and quinine
| Article | Year |
|---|---|
Grapefruit juice has no effect on quinine pharmacokinetics.
Topics: Antimalarials; Beverages; Chromatography, High Pressure Liquid; Citrus; Cross-Over Studies; Drug Interactions; Humans; Male; Quinidine; Quinine | 1999 |
The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo.
Topics: Adult; Antifungal Agents; Antimalarials; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Fluvoxamine; Humans; Hydroxylation; Ketoconazole; Male; Mixed Function Oxygenases; Quinidine; Quinine; Selective Serotonin Reuptake Inhibitors | 1999 |
Effects of cigarette smoking on quinine pharmacokinetics in malaria.
Topics: Acute Disease; Adult; Antimalarials; Humans; Malaria, Falciparum; Male; Quinidine; Quinine; Smoking | 2002 |
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?
Topics: Administration, Oral; Adult; Aged; Antimalarials; Area Under Curve; Breath Tests; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Erythromycin; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Ovarian Neoplasms; Quinidine; Quinine; Troleandomycin | 2002 |
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.
Topics: Adult; Biomarkers; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Male; Middle Aged; Quinidine; Quinine | 2003 |
Metabolism and elimination of quinine in healthy volunteers.
Topics: Antimalarials; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Mixed Function Oxygenases; Quinidine; Quinine; Quinones; Time Factors | 2003 |
Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria.
Topics: Antimalarials; Area Under Curve; Female; Half-Life; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; Quinidine; Quinine; Sudan | 2007 |
Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration.
Topics: Administration, Oral; Adult; Aged; Anti-HIV Agents; Antimalarials; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; HIV Protease Inhibitors; Humans; Male; Middle Aged; Quinidine; Quinine; Ritonavir | 2010 |
Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.
Topics: Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Hydrocortisone; Hydroxycholesterols; Midazolam; Quinidine; Quinine; Rifampin | 2014 |
Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers.
Topics: Administration, Oral; Adult; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Cross-Over Studies; Dietary Supplements; Drug Interactions; Female; Garcinia kola; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Nigeria; Quinidine; Quinine; Seeds; Therapeutic Equivalency; Young Adult | 2015 |
21 other study(ies) available for 3-hydroxyquinidine and quinine
| Article | Year |
|---|---|
Disposition of quinine in rats with induced renal failure.
Topics: Acute Kidney Injury; Animals; Chromatography, High Pressure Liquid; Gentamicins; Glycerol; Injections, Intraperitoneal; Male; Mercuric Chloride; Quinidine; Quinine; Rats; Rats, Wistar; Urea | 1992 |
High-performance liquid chromatographic method for the quantitation of quinidine and selected quinidine metabolites.
Topics: Chromatography, High Pressure Liquid; Cyclic N-Oxides; Humans; Quinidine; Quinine; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1991 |
Characterization of the principal metabolite of quinine in human urine by 1H-n.m.r. spectroscopy.
Topics: Adult; Humans; Magnetic Resonance Spectroscopy; Male; Quinidine; Quinine | 1991 |
Quinidine oxidative metabolism. Identification and biosynthesis of quinidine 10,11-dihydrodiol stereoisomers.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Molecular Structure; Phenobarbital; Quinidine; Quinine; Rats; Rats, Inbred Strains; Stereoisomerism | 1990 |
Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methane; Quinidine; Quinine | 1981 |
Column liquid chromatographic analysis of quinine in human plasma, saliva and urine.
Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Primaquine; Quinidine; Quinine; Saliva; Spectrophotometry, Ultraviolet | 1993 |
Metabolism of quinine in man: identification of a major metabolite, and effects of smoking and rifampicin pretreatment.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Glucuronates; Humans; Quinidine; Quinine; Rifampin; Smoking | 1995 |
Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.
Topics: Antimalarials; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Kinetics; Male; Microsomes, Liver; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Quinidine; Quinine | 1997 |
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin | 1998 |
High-performance liquid chromatographic method for the determination of the major quinine metabolite, 3-hydroxyquinine, in plasma and urine.
Topics: Chromatography, High Pressure Liquid; Humans; Quinidine; Quinine; Sensitivity and Specificity | 1998 |
Simultaneous determination of quinine and four metabolites in plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Quinidine; Quinine; Quinones; Reproducibility of Results; Stereoisomerism | 2001 |
Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Microsomes, Liver; Pharmacokinetics; Quinidine; Quinine | 2002 |
Quinine pharmacokinetics in chronic haemodialysis patients.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Female; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Muscle Relaxants, Central; Orosomucoid; Quinidine; Quinine; Quinones; Renal Dialysis | 2002 |
High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper.
Topics: Chromatography, High Pressure Liquid; Humans; Paper; Quinidine; Quinine; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Confirmation of the structure of (3S)-3-hydroxyquinine: synthesis and X-ray crystal structure of its 9-aceto analogue.
Topics: Crystallography, X-Ray; Molecular Conformation; Molecular Structure; Quinidine; Quinine; Stereoisomerism | 2005 |
Simultaneous liquid chromatographic analysis of ritonavir, quinine and 3-hydroxyquinine in human plasma.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Quinidine; Quinine; Reference Standards; Ritonavir; Sensitivity and Specificity | 2009 |
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black People; Body Weight; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Female; Genes; Genetic Variation; Haplotypes; Humans; Immunosuppressive Agents; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Quinidine; Quinine; Sex Factors; Uganda | 2010 |
Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Quinidine; Quinine; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Solutions; Tandem Mass Spectrometry | 2011 |
Genetic epidemiology of induced CYP3A4 activity.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Biomarkers, Pharmacological; Body Mass Index; Cytochrome P-450 CYP3A; Female; Humans; Hypericum; Middle Aged; Models, Genetic; Plant Extracts; Quinidine; Quinine; Smoking; Surveys and Questionnaires | 2011 |
Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity.
Topics: Aged; Aged, 80 and over; Biomarkers; Biotransformation; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Genome-Wide Association Study; Genotype; Humans; Hydroxylation; Hypericum; Liver; Middle Aged; Phenotype; Plant Preparations; Quinidine; Quinine; Substrate Specificity; Twins | 2013 |
Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection.
Topics: Adult; Anti-HIV Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Coinfection; Drug Interactions; Female; HIV Infections; Humans; Lamivudine; Malaria, Falciparum; Nevirapine; Parasite Load; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Quinidine; Quinine; Stavudine; Treatment Outcome; Young Adult; Zidovudine | 2014 |