3-hydroxyquinidine and quinidine

3-hydroxyquinidine has been researched along with quinidine in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (27.69)	18.7374
1990's	17 (26.15)	18.2507
2000's	21 (32.31)	29.6817
2010's	9 (13.85)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adamantidis, MM; Caron, JF; Dupuis, BA; Fautrez, VM; Libersa, CC	1
Dixon, PA; Onyeji, CO; Ugwu, NC	1
Brookshier, LA; Clawson, DC; Hoyer, GL; Marcus, FI; Nolan, PE	1
Babalola, CP; Bolaji, OO; Dixon, PA	1
Brøsen, K; Davidsen, F; Gram, LF	1
Advenier, C; Leroyer, R; Pays, M; Varoquaux, O	1
Ackerman, BH; Ackerman, DJ; Chen, BH; Jordan, D; Kennedy, EE; Olsen, KM; Taylor, EH	1
Slaughter, RL; Smalley, J; Visco, J; Wooding-Scott, RA	1
Axelson, JE; Edwards, DJ; Lalka, D; Slaughter, RL; vanEvery, S; Visco, JP	1
Follath, F; Ha, HR; Nakashima, M; Uematsu, T; Vozeh, S	1
Bowers, LD; Killeen, AA	1
Follath, F; Oti-Amoako, K; Uematsu, T; Vozeh, S	1
Beckman, H; Blevins, R; Edwards, DJ; Lavoie, R; Rubenfire, M	1
Slaughter, RL; Visco, J; Wooding-Scott, RA	1
Bindschedler, M; Follath, F; Guentert, TW; Ha, HR; Kaufmann, G; Vozeh, S	1
Follath, F; Guentert, TW; Ha, HR; Uematsu, T; Vozeh, S	1
Bazin, C; Camsonne, R; Charbonneau, P; Moulin, MA	1
Bowers, LD; Connor, R; Krauss, E; Lais, CJ; Nelson, KM	1
Aubry, JP; Cheymol, G; Heckle, J; Jaillon, P; Jarreau, FX; Juliard, JM; Poirier, JM	1
Advenier, C; Jarreau, C; Leroyer, R; Pays, M; Varoquaux, O	1
Jarreau, C; Leroyer, R; Pays, M	1
Albessard, F; Bigot, MC; Camsonne, R; Mignot, P; Moulin, MA; Perault, M; Richard, O; Ryckelynck, JP	1
Bhuwapathanapun, S; Christopher, RK; Duffield, AM; Graham, GG; Liddle, C	1
Peikert, M; Reece, PA	1
Brøsen, K; Nielsen, F; Nielsen, KK	1
Babalola, CP; Bolaji, OO; Dixon, PA; Ogunbona, FA	1
Chen, J; Follath, F; Freiburghaus, AU; Ha, HR; Leuenberger, PM	1
Coville, PF; Walker, RJ; Wanwimolruk, S; Wong, SM; Zhang, H	1
Birkett, DJ; Coville, PF; Miners, JO; Walker, RJ; Wanwimolruk, S; Zhang, H	1
Ishizaki, T; Kawashiro, T; Zhao, XJ	1
Ericsson, O; Gustafsson, LL; Mirghani, RA	1
Chalcroft, SC; Coville, PF; Ho, PC; Wanwimolruk, S	1
Brøsen, K; Damkier, P; Hansen, LL	1
Bhattacharjee, AK; Karle, JM	1
Bertilsson, L; Ericsson, O; Gustafsson, LL; Hellgren, U; Mirghani, RA; Westerberg, PA	1
Benton, RE; Flockhart, DA; Sale, M; Woosley, RL	1
Brøsen, K; Damkier, P	1
Cook, J; Ericsson, O; Gustafsson, LL; Mirghani, RA; Yu, P	1
Bhoopathy, S; Karnes, HT	1
Jantra, A; Pitisuttithum, P; Pukrittayakamee, S; Wanwimolruk, S; White, NJ; Zhang, H	1
Bhoopathy, S; Karnes, HT; Sarkar, MA	1
Cook, JM; Ericsson, O; Gustafsson, LL; Mirghani, RA; Tybring, G; Yasar, U; Zheng, T	1
Bannon, P; Roy, L; Villeneuve, JP	1
Paine, MF; Pusek, SN; Wanwimolruk, S; Watkins, PB	1
Bertilsson, L; Ericsson, O; Gustafsson, LL; Mirghani, RA; Tybring, G	1
Busch, CM; Mishin, VM; Parimoo, B; Thomas, PE	1
Bertilsson, L; Ericsson, O; Gustafsson, LL; Hellgren, U; Mirghani, RA	1
Gustafsson, LL; Jansson, A; Mirghani, RA	1
Bidstrup, TB; Brøsen, K; Damkier, P; Scharling, B; Stilling, N; Thomsen, MS	1
Cook, JM; Deschamps, JR; Han, D; Srirama Sarma, PV	1
Bidstrup, TB; Brøsen, K; Damkier, P; Ekblom, M; Karlsson, A; Olsen, AK	1
Lirussi, F; Pussard, E	1
Allqvist, A; Bertilsson, L; Mirghani, RA; Miura, J	1
Abdelrahim, II; Adam, I; Elbashir, MI; Elghazali, G; Gustafsson, LL; Mirghani, RA	1
Andreasen, AH; Brøsen, K; Damkier, P	1
Omoruyi, SI; Onyeji, CO; Soyinka, JO	1
Cook, JM; Omoruyi, SI; Onyeji, CO; Owolabi, AR; Sarma, PV; Soyinka, JO	1
Aklillu, E; Gustafsson, LL; Mukonzo, JK; Ogwal-Okeng, J; Waako, P	1
Ahmadi, KR; Heaton, J; Legido-Quigley, C; Rahmioglu, N; Smith, NW	1
Ahmadi, KR; Clement, G; Gill, R; Heaton, J; Hider, RC; Hodgkiss, D; Ma, Y; Rahmioglu, N; Smith, NW; Surdulescu, G; Zlobecka, K	1
Ahmadi, KR; Clement, G; Gill, R; Heaton, J; Hodgkiss, D; Rahmioglu, N; Smith, NW; Surdulescu, G; Zlobecka, K	1
Doumbo, OK; Guirou, EA; Hendrix, CW; Kayentao, K; Nyunt, MM; Parsons, TL; Plowe, CV; Venkatesan, M	1
Andersson, TB; Bäckström, T; Bertilsson, L; Björkhem-Bergman, L; Bredberg, E; Diczfalusy, U; Nylén, H; Rönquist-Nii, Y	1
Akanmu, MA; Cook, JM; Igbinoba, SI; Nathaniel, TI; Onyeji, CO; Pullela, SS; Soyinka, JO	1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M; van de Steeg, E	1

Trials

18 trial(s) available for 3-hydroxyquinidine and quinidine

Article	Year
The effect of coadministration of verapamil on the pharmacokinetics and metabolism of quinidine. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:1 Topics: Adult; Analysis of Variance; Drug Administration Schedule; Drug Interactions; Half-Life; Humans; Kinetics; Male; Quinidine; Random Allocation; Verapamil	1987
Pharmacodynamics of 3-hydroxyquinidine alone and in combination with quinidine in healthy persons. The American journal of cardiology, 1987, Mar-01, Volume: 59, Issue:6 Topics: Adult; Dose-Response Relationship, Drug; Drug Combinations; Female; Heart Rate; Humans; Male; Quinidine	1987
Grapefruit juice has no effect on quinine pharmacokinetics. European journal of clinical pharmacology, 1999, Volume: 55, Issue:5 Topics: Antimalarials; Beverages; Chromatography, High Pressure Liquid; Citrus; Cross-Over Studies; Drug Interactions; Humans; Male; Quinidine; Quinine	1999
Effect of fluvoxamine on the pharmacokinetics of quinidine. European journal of clinical pharmacology, 1999, Volume: 55, Issue:6 Topics: Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Fluvoxamine; Humans; Male; Metabolic Clearance Rate; Quinidine; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	1999
The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo. Clinical pharmacology and therapeutics, 1999, Volume: 66, Issue:5 Topics: Adult; Antifungal Agents; Antimalarials; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Fluvoxamine; Humans; Hydroxylation; Ketoconazole; Male; Mixed Function Oxygenases; Quinidine; Quinine; Selective Serotonin Reuptake Inhibitors	1999
Greater quinidine-induced QTc interval prolongation in women. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:4 Topics: Adult; Anti-Arrhythmia Agents; Area Under Curve; Cross-Over Studies; Electroencephalography; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Quinidine; Sex Factors; Single-Blind Method	2000
Quinidine as a probe for CYP3A4 activity: intrasubject variability and lack of correlation with probe-based assays for CYP1A2, CYP2C9, CYP2C19, and CYP2D6. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:2 Topics: Adolescent; Adult; Antimalarials; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Male; Mixed Function Oxygenases; Quinidine; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases	2000
Effects of cigarette smoking on quinine pharmacokinetics in malaria. European journal of clinical pharmacology, 2002, Volume: 58, Issue:5 Topics: Acute Disease; Adult; Antimalarials; Humans; Malaria, Falciparum; Male; Quinidine; Quinine; Smoking	2002
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4? British journal of clinical pharmacology, 2002, Volume: 54, Issue:6 Topics: Administration, Oral; Adult; Aged; Antimalarials; Area Under Curve; Breath Tests; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Erythromycin; Female; Humans; Liver; Male; Metabolic Clearance Rate; Middle Aged; Molecular Probes; Ovarian Neoplasms; Quinidine; Quinine; Troleandomycin	2002
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man. European journal of clinical pharmacology, 2003, Volume: 59, Issue:1 Topics: Adult; Biomarkers; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Fluvoxamine; Humans; Hydroxylation; Isoenzymes; Ketoconazole; Male; Middle Aged; Quinidine; Quinine	2003
Metabolism and elimination of quinine in healthy volunteers. European journal of clinical pharmacology, 2003, Volume: 59, Issue:5-6 Topics: Antimalarials; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fluvoxamine; Humans; Ketoconazole; Mixed Function Oxygenases; Quinidine; Quinine; Quinones; Time Factors	2003
Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide. European journal of clinical pharmacology, 2004, Volume: 60, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carbamates; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Hydrocortisone; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Quinidine; Rifampin; Time Factors	2004
The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide. British journal of clinical pharmacology, 2006, Volume: 61, Issue:1 Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Blood Glucose; Carbamates; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP2C8; Genotype; Humans; Hypoglycemic Agents; Male; Piperidines; Polymorphism, Genetic; Quinidine	2006
Pharmacokinetics of quinine and its metabolites in pregnant Sudanese women with uncomplicated Plasmodium falciparum malaria. Journal of clinical pharmacy and therapeutics, 2007, Volume: 32, Issue:1 Topics: Antimalarials; Area Under Curve; Female; Half-Life; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Complications, Parasitic; Quinidine; Quinine; Sudan	2007
A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. Epilepsia, 2007, Volume: 48, Issue:3 Topics: Administration, Oral; Adult; Anticonvulsants; Area Under Curve; Biomarkers; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Male; Oxcarbazepine; Quinidine	2007
Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration. British journal of clinical pharmacology, 2010, Volume: 69, Issue:3 Topics: Administration, Oral; Adult; Aged; Anti-HIV Agents; Antimalarials; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; HIV Protease Inhibitors; Humans; Male; Middle Aged; Quinidine; Quinine; Ritonavir	2010
Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin. Drug metabolism and pharmacokinetics, 2014, Volume: 29, Issue:4 Topics: Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Hydrocortisone; Hydroxycholesterols; Midazolam; Quinidine; Quinine; Rifampin	2014
Effect of dehusked Garcinia kola seeds on the overall pharmacokinetics of quinine in healthy Nigerian volunteers. Journal of clinical pharmacology, 2015, Volume: 55, Issue:3 Topics: Administration, Oral; Adult; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Cross-Over Studies; Dietary Supplements; Drug Interactions; Female; Garcinia kola; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Nigeria; Quinidine; Quinine; Seeds; Therapeutic Equivalency; Young Adult	2015

Other Studies

47 other study(ies) available for 3-hydroxyquinidine and quinidine

Article	Year
Comparative electrophysiologic effects of metabolites of quinidine and hydroquinidine. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrophysiology; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Potassium; Purkinje Fibers; Quinidine; Rabbits	1992
Disposition of quinine in rats with induced renal failure. Pharmaceutisch weekblad. Scientific edition, 1992, Aug-21, Volume: 14, Issue:4 Topics: Acute Kidney Injury; Animals; Chromatography, High Pressure Liquid; Gentamicins; Glycerol; Injections, Intraperitoneal; Male; Mercuric Chloride; Quinidine; Quinine; Rats; Rats, Wistar; Urea	1992
High-performance liquid chromatographic method for the quantitation of quinidine and selected quinidine metabolites. Journal of chromatography, 1991, Dec-06, Volume: 572, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Cyclic N-Oxides; Humans; Quinidine; Quinine; Reproducibility of Results; Spectrophotometry, Ultraviolet	1991
Characterization of the principal metabolite of quinine in human urine by 1H-n.m.r. spectroscopy. Xenobiotica; the fate of foreign compounds in biological systems, 1991, Volume: 21, Issue:4 Topics: Adult; Humans; Magnetic Resonance Spectroscopy; Male; Quinidine; Quinine	1991
Quinidine kinetics after a single oral dose in relation to the sparteine oxidation polymorphism in man. British journal of clinical pharmacology, 1990, Volume: 29, Issue:2 Topics: Adult; Biotransformation; Female; Humans; Male; Oxidation-Reduction; Polymorphism, Genetic; Quinidine; Sparteine	1990
Quinidine oxidative metabolism. Identification and biosynthesis of quinidine 10,11-dihydrodiol stereoisomers. Biomedical chromatography : BMC, 1990, Volume: 4, Issue:2 Topics: Animals; Bile; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Molecular Structure; Phenobarbital; Quinidine; Quinine; Rats; Rats, Inbred Strains; Stereoisomerism	1990
Disposition of 3-hydroxyquinidine in patients receiving initial intravenous quinidine gluconate for electrophysiology testing of ventricular tachycardia. DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:5 Topics: Adult; Aged; Anti-Arrhythmia Agents; Electrophysiology; Female; Half-Life; Humans; Injections, Intravenous; Male; Middle Aged; Quinidine; Tachycardia	1989
The pharmacokinetics and pharmacodynamics of quinidine and 3-hydroxyquinidine. British journal of clinical pharmacology, 1988, Volume: 26, Issue:4 Topics: Adult; Electrocardiography; Humans; Male; Protein Binding; Quinidine	1988
Lack of effect of smoking on the metabolism and pharmacokinetics of quinidine in patients. British journal of clinical pharmacology, 1987, Volume: 23, Issue:3 Topics: Aged; Cyclic N-Oxides; Humans; Kinetics; Metabolic Clearance Rate; Middle Aged; Quinidine; Smoking	1987
Method for stable measurement of the electrocardiogram in isolated guinea pig heart. Evaluation of the RR-QT relationship and the effect of quinidine. Journal of pharmacological methods, 1987, Volume: 18, Issue:2 Topics: Animals; Electrocardiography; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Quinidine	1987
Fetal supraventricular tachycardia treated with high-dose quinidine: toxicity associated with marked elevation of the metabolite, 3(S)-3-hydroxyquinidine. Obstetrics and gynecology, 1987, Volume: 70, Issue:3 Pt 2 Topics: Adult; Amniotic Fluid; Chromatography, High Pressure Liquid; Female; Fetal Blood; Fetal Diseases; Fetal Heart; Humans; Nausea; Pregnancy; Quinidine; Tachycardia, Supraventricular; Vomiting	1987
Antiarrhythmic activity of two quinidine metabolites in experimental reperfusion arrhythmia: relative potency and pharmacodynamic interaction with the parent drug. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic N-Oxides; Heart Rate; In Vitro Techniques; Kinetics; Male; Perfusion; Quinidine; Rats; Rats, Inbred Strains; Structure-Activity Relationship	1987
Total and unbound concentrations of quinidine and 3-hydroxyquinidine at steady state. American heart journal, 1987, Volume: 113, Issue:2 Pt 1 Topics: Aged; Arrhythmias, Cardiac; Binding, Competitive; Homeostasis; Humans; Liver; Liver Diseases; Quinidine	1987
Kinetics and electrocardiographic changes after oral 3-OH-quinidine in healthy subjects. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:5 Topics: Absorption; Administration, Oral; Adult; Blood Pressure; Electrocardiography; Half-Life; Heart Rate; Humans; Kinetics; Male; Quinidine	1985
Elimination kinetic of high polar metabolites pool of quinidine from human serum. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:2 Topics: Barbiturates; Half-Life; Humans; Kinetics; Metabolic Clearance Rate; Quinidine; Time Factors	1985
Evidence supporting 3(S)-3-hydroxyquinidine-associated cardiotoxicity. Therapeutic drug monitoring, 1985, Volume: 7, Issue:3 Topics: Biotransformation; Female; Heart Diseases; Humans; Middle Aged; Quinidine; Retrospective Studies; Tachycardia	1985
[Comparison of the cardiac electrophysiologic effects of quinidine, 3-hydroxyquinidine and 3-hydroxyhydroquinidine in the anesthesized dog. Study of plasma dose response relations]. Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76, Issue:6 Topics: Animals; Cardiac Pacing, Artificial; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Heart Rate; Quinidine	1983
Reverse-phase liquid chromatography and pharmacokinetic study of two hydroxylated analogues of quinidine in dogs. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:6 Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dogs; Injections, Intravenous; Kinetics; Quinidine; Spectrometry, Fluorescence	1984
Specific determination of quinidine and metabolites in biological fluids by reversed-phase high-performance liquid chromatography. Journal of chromatography, 1982, Mar-12, Volume: 228 Topics: Chromatography, High Pressure Liquid; Humans; Quinidine	1982
[Chronic renal insufficiency. Elevated levels of the active metabolite (3-hydroxyquinidine) of quinidine]. La Nouvelle presse medicale, 1982, Oct-16, Volume: 11, Issue:41 Topics: Adult; Humans; Kidney Failure, Chronic; Male; Quinidine	1982
Identification of new urinary metabolites in man of quinine using methane chemical ionization gas chromatography-mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems, 1981, Volume: 11, Issue:2 Topics: Gas Chromatography-Mass Spectrometry; Humans; Methane; Quinidine; Quinine	1981
Simple and selective high-performance liquid chromatographic method for estimating plasma quinidine levels. Journal of chromatography, 1980, Feb-08, Volume: 181, Issue:2 Topics: Chromatography, High Pressure Liquid; Humans; Quinidine	1980
Determination of quinidine, dihydroquinidine, (3S)-3-hydroxyquinidine and quinidine N-oxide in plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications, 1994, Oct-03, Volume: 660, Issue:1 Topics: Chromatography, High Pressure Liquid; Cyclic N-Oxides; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Parasympatholytics; Quinidine; Spectrometry, Fluorescence	1994
Column liquid chromatographic analysis of quinine in human plasma, saliva and urine. Journal of chromatography, 1993, Jun-23, Volume: 616, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Primaquine; Quinidine; Quinine; Saliva; Spectrophotometry, Ultraviolet	1993
In vitro inhibition of midazolam and quinidine metabolism by flavonoids. European journal of clinical pharmacology, 1995, Volume: 48, Issue:5 Topics: Anti-Arrhythmia Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Flavonoids; Humans; Kinetics; Midazolam; Mixed Function Oxygenases; Quinidine	1995
Metabolism of quinine in man: identification of a major metabolite, and effects of smoking and rifampicin pretreatment. The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:11 Topics: Antimalarials; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Glucuronates; Humans; Quinidine; Quinine; Rifampin; Smoking	1995
Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. British journal of clinical pharmacology, 1997, Volume: 43, Issue:3 Topics: Antimalarials; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Kinetics; Male; Microsomes, Liver; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Quinidine; Quinine	1997
Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways. Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:2 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Etoposide; Humans; Ketoconazole; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Quinidine; Quinine; Troleandomycin	1998
High-performance liquid chromatographic method for the determination of the major quinine metabolite, 3-hydroxyquinine, in plasma and urine. Journal of chromatography. B, Biomedical sciences and applications, 1998, Apr-24, Volume: 708, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Humans; Quinidine; Quinine; Sensitivity and Specificity	1998
Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity. Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:9 Topics: Animals; Antimalarials; Cinchona Alkaloids; Plasmodium falciparum; Protons; Quinidine; Static Electricity; Structure-Activity Relationship	1999
Simultaneous determination of quinine and four metabolites in plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 2001, Apr-15, Volume: 754, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Quinidine; Quinine; Quinones; Reproducibility of Results; Stereoisomerism	2001
Determination of (3S)-3-hydroxy quinidine for metabolism screening experiments using direct injection capillary electrophoresis and laser-induced fluorescence detection. Biomedical chromatography : BMC, 2002, Volume: 16, Issue:1 Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Enzyme Inhibitors; Lasers; Microsomes, Liver; Mixed Function Oxygenases; Quinidine; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2002
Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2002, Volume: 16, Issue:4-5 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Electrophoresis, Capillary; Enzyme Inhibitors; Erythromycin; Fluconazole; Hydroxylation; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Quinidine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism	2002
Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:12 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Microsomes, Liver; Pharmacokinetics; Quinidine; Quinine	2002
Quinine pharmacokinetics in chronic haemodialysis patients. British journal of clinical pharmacology, 2002, Volume: 54, Issue:6 Topics: Administration, Oral; Adult; Aged; Area Under Curve; Female; Humans; Kidney Failure, Chronic; Male; Metabolic Clearance Rate; Middle Aged; Muscle Relaxants, Central; Orosomucoid; Quinidine; Quinine; Quinones; Renal Dialysis	2002
Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies. Archives of biochemistry and biophysics, 2003, Jun-15, Volume: 414, Issue:2 Topics: Animals; Antibodies, Monoclonal; Baculoviridae; Blotting, Western; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Epitopes; Escherichia coli; Glutathione Transferase; Humans; Immunoglobulin G; Mice; Mice, Inbred BALB C; Microsomes, Liver; Models, Genetic; Plasmids; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Tertiary; Quinidine; Recombinant Fusion Proteins; Sequence Analysis, DNA	2003
High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003, Sep-25, Volume: 795, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Paper; Quinidine; Quinine; Reproducibility of Results; Sensitivity and Specificity	2003
Confirmation of the structure of (3S)-3-hydroxyquinine: synthesis and X-ray crystal structure of its 9-aceto analogue. Journal of natural products, 2005, Volume: 68, Issue:6 Topics: Crystallography, X-Ray; Molecular Conformation; Molecular Structure; Quinidine; Quinine; Stereoisomerism	2005
Quinine distribution in pregnant mice with Plasmodium berghei malaria. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Volume: 28, Issue:4 Topics: Animals; Antimalarials; Disease Models, Animal; Female; Fetus; Malaria; Mice; Placenta; Plasmodium berghei; Pregnancy; Pregnancy Complications, Parasitic; Quinidine	2006
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers. European journal of clinical pharmacology, 2007, Volume: 63, Issue:2 Topics: Alprazolam; Anti-Anxiety Agents; Antifungal Agents; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Ketoconazole; Mass Spectrometry; Microsomes, Liver; Quinidine; Stereoisomerism	2007
Simultaneous liquid chromatographic analysis of ritonavir, quinine and 3-hydroxyquinine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Feb-01, Volume: 877, Issue:4 Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Quinidine; Quinine; Reference Standards; Ritonavir; Sensitivity and Specificity	2009
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. Therapeutic drug monitoring, 2010, Volume: 32, Issue:3 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Black People; Body Weight; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Female; Genes; Genetic Variation; Haplotypes; Humans; Immunosuppressive Agents; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Quinidine; Quinine; Sex Factors; Uganda	2010
Rapid quantification of quinine and its major metabolite (3S)-3-hydroxyquinine in diluted urine by UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis, 2011, Jun-01, Volume: 55, Issue:3 Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Quinidine; Quinine; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Solutions; Tandem Mass Spectrometry	2011
Genetic epidemiology of induced CYP3A4 activity. Pharmacogenetics and genomics, 2011, Volume: 21, Issue:10 Topics: Aged; Aged, 80 and over; Alcohol Drinking; Biomarkers, Pharmacological; Body Mass Index; Cytochrome P-450 CYP3A; Female; Humans; Hypericum; Middle Aged; Models, Genetic; Plant Extracts; Quinidine; Quinine; Smoking; Surveys and Questionnaires	2011
Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity. European journal of drug metabolism and pharmacokinetics, 2013, Volume: 38, Issue:1 Topics: Aged; Aged, 80 and over; Biomarkers; Biotransformation; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Genome-Wide Association Study; Genotype; Humans; Hydroxylation; Hypericum; Liver; Middle Aged; Phenotype; Plant Preparations; Quinidine; Quinine; Substrate Specificity; Twins	2013
Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection. The American journal of tropical medicine and hygiene, 2014, Volume: 90, Issue:3 Topics: Adult; Anti-HIV Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Coinfection; Drug Interactions; Female; HIV Infections; Humans; Lamivudine; Malaria, Falciparum; Nevirapine; Parasite Load; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Quinidine; Quinine; Stavudine; Treatment Outcome; Young Adult; Zidovudine	2014
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo. Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 40 Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colon; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Ileum; In Vitro Techniques; Isoquinolines; Jejunum; Ketoconazole; Male; Middle Aged; Quinazolines; Quinidine; Verapamil	2017