Page last updated: 2024-09-04

3-hydroxylidocaine and monoethylglycinexylidide

3-hydroxylidocaine has been researched along with monoethylglycinexylidide in 8 studies

Compound Research Comparison

Studies (3-hydroxylidocaine)	Trials (3-hydroxylidocaine)	Recent Studies (post-2010) (3-hydroxylidocaine)	Studies (monoethylglycinexylidide)	Trials (monoethylglycinexylidide)	Recent Studies (post-2010) (monoethylglycinexylidide)
10	2	1	346	58	20

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (62.50)	18.2507
2000's	2 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (12.50)	2.80

Authors

Authors	Studies
Gray, MR; Saville, BA; Tam, YK	1
Cerra, FB; Hu, WS; Mann, HJ; Nyberg, SL; Peshwa, MV; Remmel, RP	1
Fujimori, M; Funae, Y; Imaoka, S; Nakamoto, T; Oda, Y	1
Bass, S; Boyles, J; Carter, WG; Dirikolu, L; Harkins, JD; Karpiesiuk, W; Lehner, A; Mundy, GD; Rees, WA; Tobin, T; Woods, WE	1
Backman, JT; Kivistö, KT; Neuvonen, PJ; Taavitsainen, P; Wang, JS; Wen, X	1
Ahonen, J; Isohanni, MH; Neuvonen, PJ; Olkkola, KT	1
Isohanni, MH; Neuvonen, PJ; Olkkola, KT	1
Arthur, RM; Blea, J; Katzman, S; Knych, HK; McKemie, DS	1

Trials

2 trial(s) available for 3-hydroxylidocaine and monoethylglycinexylidide

Article	Year
Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine. European journal of anaesthesiology, 2005, Volume: 22, Issue:10 Topics: Adult; Anesthetics, Local; Anti-Infective Agents; Biotransformation; Ciprofloxacin; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Lidocaine; Male	2005
Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine. Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:2 Topics: Administration, Oral; Adult; Anesthetics, Local; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Erythromycin; Female; Fluvoxamine; Half-Life; Humans; Lidocaine; Male; Metabolic Clearance Rate; Nausea	2006

Article

Year

Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine.

European journal of anaesthesiology, 2005, Volume: 22, Issue:10

Topics: Adult; Anesthetics, Local; Anti-Infective Agents; Biotransformation; Ciprofloxacin; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Lidocaine; Male

2005

Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.

Basic & clinical pharmacology & toxicology, 2006, Volume: 99, Issue:2

Topics: Administration, Oral; Adult; Anesthetics, Local; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Erythromycin; Female; Fluvoxamine; Half-Life; Humans; Lidocaine; Male; Metabolic Clearance Rate; Nausea

2006

Other Studies

6 other study(ies) available for 3-hydroxylidocaine and monoethylglycinexylidide

Article	Year
Experimental studies of transient mass transfer and reaction in the liver: interpretation with a heterogeneous compartment model. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:3 Topics: Animals; Extracellular Space; In Vitro Techniques; Lidocaine; Liver; Male; Mathematical Computing; Models, Biological; Pharmacokinetics; Rats; Rats, Inbred Strains	1992
Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver. Annals of surgery, 1994, Volume: 220, Issue:1 Topics: Albumins; Animals; Artificial Organs; Biotransformation; Cell Line, Transformed; Cell Transformation, Neoplastic; Cells, Cultured; Glucose; Lactates; Lactic Acid; Lidocaine; Liver; Male; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Time Factors; Urea	1994
Effect of phenobarbital on the pharmacokinetics of lidocaine, monoethylglycinexylidide and 3-hydroxylidocaine in the rat: correlation with P450 isoform levels. Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:3 Topics: Anesthetics, Local; Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Hypnotics and Sedatives; Isoenzymes; Lidocaine; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Sprague-Dawley	1997
Lidocaine in the horse: its pharmacological effects and their relationship to analytical findings. Journal of veterinary pharmacology and therapeutics, 1998, Volume: 21, Issue:6 Topics: Anesthetics, Local; Animals; Chromatography; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Horses; Injections, Subcutaneous; Lidocaine; Random Allocation; Reproducibility of Results	1998
Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro. Pharmacology & toxicology, 1999, Volume: 85, Issue:5 Topics: Anesthetics, Local; Autopsy; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythromycin; Fluvoxamine; Humans; In Vitro Techniques; Ketoconazole; Lidocaine; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases	1999
Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block. BMC veterinary research, 2023, Oct-30, Volume: 19, Issue:1 Topics: Anesthetics, Local; Animals; Epinephrine; Horses; Lidocaine; Nerve Block	2023