3-hydroxyaspartic acid has been researched along with aspartic acid in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (18.49) | 18.7374 |
| 1990's | 49 (33.56) | 18.2507 |
| 2000's | 52 (35.62) | 29.6817 |
| 2010's | 16 (10.96) | 24.3611 |
| 2020's | 2 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Piek, T; Schluter, NC; Van Marle, J; Van Weeren-Kramer, J | 1 |
| Bachurin, SO; Drany, OA; Petrova, LN; Solyakov, LS | 1 |
| Long, GL; Nelson, RM | 1 |
| Iwanaga, S; Nishimura, H; Walz, DA; Yamashita, S; Zeng, Z | 1 |
| Marini, A; Novelli, A | 1 |
| Attwell, D; Barbour, B; Brew, H | 1 |
| Adams, RN; Cammack, J; Ghasemzadeh, B | 1 |
| Flott, B; Seifert, W | 1 |
| Friedman, PA; Long, GL; Nelson, RM; VanDusen, WJ | 1 |
| Stenflo, J | 2 |
| Anderson, KJ; Vickroy, TW | 1 |
| Bourdon, P; Landes, G; Ohlin, AK; Oppenheimer, C; Stenflo, J; Wydro, R | 1 |
| Hiromi, K; Inoue, K; Inoue, Y; Kagamiyama, H; Kuramitsu, S; Morino, Y; Tanase, S | 1 |
| Kopin, IJ; Marini, AM; Schwartz, JP | 1 |
| Drakenberg, T; Linse, S; Ohlin, AK; Persson, E; Selander, M; Stenflo, J | 1 |
| Bennett, CD; Friedman, PA; Musson, DG; Przysiecki, CT; Ramjit, HG; Staggers, JE; Stern, AM | 1 |
| Ohlin, AK; Owen, WG; Schneider, WJ; Stenflo, J | 1 |
| McBean, GJ; Roberts, PJ | 1 |
| Higashima, M; Sawada, S; Yamamoto, C | 1 |
| Danbolt, NC; Storm-Mathisen, J | 1 |
| Bradford, HF; Crowder, JM; Young, AM | 2 |
| Brownlee, GG; Esnouf, MP; Handford, PA; Jones, IM; Rees, DJ; Smith, KJ; Walter, SJ | 1 |
| Persson, U; Stenflo, J; Sugo, T | 1 |
| Kisiel, W; Morita, T | 1 |
| Fowler, SA; Owen, BA; Owen, WG; Paulson, D | 1 |
| Balázs, R; Bosley, TM; Gordon, RD; Woodhams, PL | 1 |
| Fernlund, P; Stenflo, J | 2 |
| Fujikawa, K; Kisiel, W; McMullen, BA | 1 |
| Fernlund, P; Stenflo, J; Sugo, T | 1 |
| Fujikawa, K; Howald, WN; Kisiel, W; Kwa, EY; McMullen, BA; Sasagawa, T; Weinstein, B | 1 |
| Bornstein, JC; Curtis, DR; Johnston, GA; Lodge, D | 1 |
| Balcar, VJ; Killinger, S; Li, Y | 1 |
| Larsson, HP; Lecar, H; Picaud, S; Wellis, DP; Werblin, F | 1 |
| Hayashi, H; Kagamiyama, H | 1 |
| Krämer, R; Peekhaus, N; Poolman, B; Tolner, B | 1 |
| Héron, A; Lasbennes, F; Seylaz, J; Springhetti, V | 1 |
| Ballio, A; Takemoto, JY | 1 |
| Ishida, M; Kataoka, K; Nakamura, Y; Shinozaki, H | 1 |
| Chen, J; Graham, SH; Swanson, RA | 1 |
| Schlemermeyer, E; Schütte, M | 1 |
| Balcar, VJ; Bao, S; King, NJ; Shen, J | 1 |
| Mennerick, S; Zorumski, CF | 1 |
| Balcar, VJ; Li, Y | 1 |
| Jahr, CE; Tong, G | 1 |
| Hansen, L; Suzdak, PD; Thomsen, C | 1 |
| Johnston, GA; Mitrovic, AD | 1 |
| Greenberg, DA; Koretz, B; Lustig, HS; von B Ahern, K; Wang, N | 1 |
| Dykes-Hoberg, M; Jin, L; Kuncl, RW; Rothstein, JD | 1 |
| Bruhn, T; Christensen, T; Diemer, NH | 1 |
| Larsson, HP; Lecar, H; Picaud, SA; Werblin, FS | 1 |
| Massieu, L; Tapia, R; Velasco, I | 1 |
| Girolami, A; James, HL; Kim, DJ | 1 |
| Mennerick, S; Que, J; Zorumski, CF | 1 |
| Allan, RD; Balcar, VJ; Bested, A; Blume, GL; Bohart, L; Cooper, B; Dias, LS; Killinger, S | 1 |
| Boutelle, MG; Fillenz, M; Forsyth, RJ; Fray, AE | 1 |
| Chevalier, D; Mu, X; Welbourne, TC | 1 |
| von Stosch, AG | 1 |
| Boutelle, M; Demestre, M; Fillenz, M | 1 |
| Czerlinski, G; Levin, R; Ypma, T | 1 |
| Diamond, JS; Jahr, CE | 2 |
| Berg, ME; Ganley, JP; Langford, MP; Mack, JH; Welbourne, TC | 1 |
| Jahr, CE; Kavanaugh, MP; Otis, TS | 1 |
| Alexander, GM; Gordon, SW; Grothusen, JR; Schwartzman, RJ | 1 |
| Hirata, A; Kamakura, K; Kwak, S; Nagata, N; Nakamura, R | 1 |
| Lebrun, B; Nakajima, T; Sakaitani, M; Shigeri, Y; Shimamoto, K; Yasuda-Kamatani, Y; Yumoto, N | 1 |
| Crosson, CE; Ganel, R | 1 |
| Davis, RE | 1 |
| Bar-Peled, O; Knudson, M; Korsmeyer, SJ; Rothstein, JD | 1 |
| Debernardi, R; Magistretti, PJ; Pellerin, L | 1 |
| Araque, A; Doyle, RT; Haydon, PG; Li, N | 1 |
| Hülsmann, S; Oku, Y; Richter, DW; Zhang, W | 1 |
| Baba, A; Hashimoto, H; Ishibashi, T; Koyama, Y; Matsuda, T; Okamoto, T | 1 |
| Trussell, LO; Turecek, R | 1 |
| Isaac, JT; Kidd, FL | 2 |
| Boussin, FD; Dereuddre-Bosquet, N; Dormont, D; Gras, G; Haïk, S; Le Grand, R; Martin, M; Rimaniol, AC | 1 |
| Gorbachevskaia, AI; Mikhaĭlova, MO; Saul'skaia, NB | 1 |
| Aguilar-Veiga, E; Galán-Valiente, J; Sierra-Marcuño, G; Sierra-Paredes, G; Vazquez-Illanes, MD | 1 |
| Gramsbergen, JB; Kornblit, BT; Storgaard, J; Zimmer, J | 1 |
| Barnstable, CJ; Kawasaki, A; Otori, Y | 1 |
| Bézine, MF; Gaillet, S; Malaval, F; Plachez, C; Récasens, M | 1 |
| Abe, K; Saito, H | 1 |
| Chatton, JY; Magistretti, PJ; Shimamoto, K | 1 |
| Nissim, I; Welbourne, T | 1 |
| Barrionuevo, G; Fleck, MW; Palmer, AM | 1 |
| Allen, JW; Aschner, M; Mutkus, LA | 1 |
| Kosakai, K; Yoshino, M | 1 |
| Allen, JW; Aschner, M; Mutkus, LA; Shanker, G | 1 |
| Amara, SG; Nakajima, T; Seal, RP; Shigeri, Y; Shimamoto, K; Yasuda-Kamatani, Y; Yumoto, N | 1 |
| Anderson, CM; Bridges, RJ; Chamberlin, AR; Shimamoto, K; Swanson, RA; Yasuda-Kamatani, Y | 1 |
| Castellino, FJ; Ploplis, VA; Zhang, L | 2 |
| Burdohan, JA; Byrne, JH; Chin, J; Eskin, A | 1 |
| Baba, A; Ikegaya, Y; Matsuki, N; Matsuura, S; Nishiyama, N; Ueno, S; Yamada, MK | 1 |
| Mikhailova, MO; Saulskaya, NB | 1 |
| Falzano, L; Fiorentini, C; Frank, C; Giammarioli, AM; Rufini, S | 1 |
| Loopuijt, LD | 1 |
| Barra, HS; Casale, CH; Previtali, G | 1 |
| Bordey, A; Sontheimer, H | 1 |
| Chen, Y; Swanson, RA | 1 |
| Diamond, JS; Mathews, GC | 1 |
| Zheng, S; Zuo, Z | 1 |
| Liang, PJ; Luo, FJ | 1 |
| Hattori, G; Higashi, H; Shigemori, M; Tanaka, E; Yokomizo, Y | 1 |
| Dairi, T; Itoh, N; Kataoka, M; Liu, JQ; Shimizu, S | 1 |
| Nakamori, S; Takagi, H; Wada, M | 1 |
| KORNGUTH, ML; SALLACH, HJ | 2 |
| EVANS, RL; STAVELY, HE; ZYGMUNT, WA | 1 |
| JENKINS, WT | 1 |
| Sulzer, D; Zhang, H | 1 |
| Fei, J; Guo, LH; Hu, JH; Jiang, J; Ma, YH; Yang, N; Zhang, JF | 1 |
| Grebenyuk, S; Kirichok, Y; Krishtal, O; Lozovaya, N; Melnik, S; Tsintsadze, T | 1 |
| Dodson, PD; Karakossian, MH; Meera, P; Otis, TS | 1 |
| Borisova, T; Himmelreich, N | 1 |
| Kim, YK; Leonard, BE; Myint, AM; Park, SH; Scharpé, S; Steinbusch, HW; Verkerk, R | 1 |
| Datta, A; Khalaf, JK | 1 |
| Bonomo, J; Gill, RT; Lynch, MD; Price, JV; Warnecke, T | 1 |
| Essen, LO; Marahiel, MA; Strieker, M; Walsh, CT | 1 |
| Armstrong, EJ; Hemendinger, RA; Mougeot, JL; Persinski, R; Rosenfeld, J; Todd, J; Volvovitz, F | 1 |
| Borisova, T; Kasatkina, L | 1 |
| Guo, Y; Li, B; Li, C; Sun, M; Yu, J; Zhang, Y | 1 |
| Ikarashi, Y; Kanno, H; Kase, Y; Kawakami, Z; Tabuchi, M; Terawaki, K; Ueki, T | 1 |
| Ishige, K; Ito, Y; Kosuge, Y; Negi, H; Sekikawa-Nishida, K | 1 |
| Grieb, P; Matyja, E; Nagańska, E; Rafałowska, J; Taraszewska, A | 1 |
| Khristoforov, R; Lima, S; Phillips, RS; Sudararaju, B | 1 |
| Bu, H; Fan, ZL; Li, B; Li, CY; Li, Z; Liu, XY; Ren, WB; Sun, MM; Tian, M; Zhang, L | 1 |
| Barisic, L; Binetti, D; Bionda, N; Cudic, M; Cudic, P; Stawikowska, R; Stawikowski, M | 1 |
| Constandil, L; Hernández, A; Laurido, C; Pelissier, T | 1 |
| Guilarte, TR; Kang, J; Kang, N; Peng, H; Stanton, PK; Yu, Y | 1 |
| Coello, L; Cuevas, C; Fernández, R; Martín, MJ; Reyes, F | 1 |
| Cao, BB; Huang, Y; Jiang, YY; Peng, YP; Qiu, YH | 1 |
| Matsumoto, Y; Takeda, Y; Tamura, T; Wada, M; Yasutake, Y; Yokota, A | 1 |
| Hara, R; Kino, K; Nakano, M | 1 |
| Kavanaugh, AS; Langford, MP; Liang, C; Redens, TB; Texada, DE | 1 |
| Matsumoto, Y; Nagano, H; Shibano, K; Wada, M; Yokota, A | 1 |
| Fukuda, A; Kaneda, M; Miyachi, E; Ohkuma, M; Yoshida, S | 1 |
| Butler, A; Hardy, CD | 1 |
| Li, X; Liu, M; Mao, L; Wang, Y; Zhang, R; Zhang, Z; Zhao, H | 1 |
| Amann, RI; Bremer, E; Claus, P; Cortina, NS; Erb, TJ; Fuchs, BM; Gilardet, A; Glatter, T; Hermann, L; Krüger, K; Maier, UG; Pommerenke, B; Schada von Borzyskowski, L; Severi, F; Sippel, F; Zarzycki, J; Zauner, S | 1 |
| Brady, SF; Chen, S; Forelli, N; Li, X; Po, KHL; Shang, Z; Sun, Z | 1 |
| Bai, Y; Chen, L; Li, X; Liu, H; Liu, M; Meng, J | 1 |
3 review(s) available for 3-hydroxyaspartic acid and aspartic acid
| Article | Year |
|---|---|
Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Blood Coagulation Factors; Calcium; Epidermal Growth Factor; Humans; Molecular Sequence Data; Structure-Activity Relationship; Vitamin K | 1991 |
Structure and function of protein C.
Topics: Amino Acid Sequence; Amino Acids; Animals; Aspartic Acid; Base Sequence; Blood Coagulation Factors; Cattle; Chemical Phenomena; Chemistry; DNA; Endopeptidases; Factor IX; Factor V; Factor Va; Factor VIII; Factor X; Glycoproteins; Humans; Hydroxylation; Macromolecular Substances; Molecular Weight; Peptide Fragments; Protein C; Prothrombin; Serine Endopeptidases; Thrombin; Vitamin K | 1984 |
β-Hydroxyaspartic acid in siderophores: biosynthesis and reactivity.
Topics: Aspartic Acid; Molecular Structure; Siderophores | 2018 |
143 other study(ies) available for 3-hydroxyaspartic acid and aspartic acid
| Article | Year |
|---|---|
Philanthotoxins block glutamatergic transmission in rat hippocampus--I. Reduction of high affinity glutamate uptake demonstrated by light microscopy surface autoradiography.
Topics: Animals; Aspartic Acid; Autoradiography; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy; Molecular Structure; Polyamines; Rats; Rats, Inbred Strains; Synaptic Transmission; Wasp Venoms | 1992 |
Modulatory action of kainic acid on glutamate release from rat brain cortical synaptosomes.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Rats; Synaptosomes | 1992 |
Binding of protein S to C4b-binding protein. Mutagenesis of protein S.
Topics: 1-Carboxyglutamic Acid; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Base Sequence; Blood Proteins; Carrier Proteins; Cattle; Cells, Cultured; Complement Inactivator Proteins; Glycoproteins; Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein S; Recombinant Proteins; Solutions; Thrombin; Transfection | 1992 |
Evidence for the existence of O-linked sugar chains consisting of glucose and xylose in bovine thrombospondin.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Carbohydrate Metabolism; Carbohydrate Sequence; Carbohydrates; Cattle; Chickens; Epidermal Growth Factor; Glucose; Humans; Molecular Sequence Data; Molecular Weight; Oligosaccharides; Oxidation-Reduction; Peptide Fragments; Platelet Membrane Glycoproteins; Thrombospondins; Xylose | 1992 |
DL-threo-3-hydroxyaspartate reduces NMDA receptor activation by glutamate in cultured neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Kainic Acid; Neurons; Rats; Receptors, N-Methyl-D-Aspartate | 1991 |
Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.
Topics: Ambystoma; Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Membrane Potentials; Neuroglia; Potassium; Retina; Sodium | 1991 |
The pharmacological profile of glutamate-evoked ascorbic acid efflux measured by in vivo electrochemistry.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Ascorbic Acid; Aspartic Acid; Brain; Corpus Striatum; Electric Stimulation; Electrochemistry; Globus Pallidus; Glutamates; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Microinjections; N-Methylaspartate; Organ Specificity; Potentiometry; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Thalamus | 1991 |
Characterization of glutamate uptake systems in astrocyte primary cultures from rat brain.
Topics: Animals; Asparagine; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; Chlorides; Glutamates; Glutamic Acid; Ion Channels; Kinetics; Potassium; Quisqualic Acid; Rats; Sodium | 1991 |
beta-Hydroxyaspartic acid and beta-hydroxyasparagine residues in recombinant human protein S are not required for anticoagulant cofactor activity or for binding to C4b-binding protein.
Topics: Anticoagulants; Asparagine; Aspartic Acid; Calcium; Carrier Proteins; Cell Line; Complement Inactivator Proteins; DNA Mutational Analysis; Factor Va; Glycoproteins; Humans; In Vitro Techniques; Protein Binding; Protein S; Recombinant Proteins; Structure-Activity Relationship; Thrombin | 1991 |
Anatomical and pharmacological heterogeneity of D-[3H]aspartate binding sites.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Stereoisomerism | 1990 |
Beta-hydroxyaspartic acid in the first epidermal growth factor-like domain of protein C. Its role in Ca2+ binding and biological activity.
Topics: Antibodies, Monoclonal; Aspartic Acid; Base Sequence; Calcium; Epidermal Growth Factor; Epitopes; Humans; Kinetics; Molecular Sequence Data; Protein C | 1988 |
Substitution of a lysyl residue for arginine 386 of Escherichia coli aspartate aminotransferase.
Topics: Amino Acid Sequence; Arginine; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Catalysis; Escherichia coli; Kinetics; Lysine; Mutation; N-Methylaspartate; Substrate Specificity | 1989 |
The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Designer Drugs; Excitatory Amino Acid Antagonists; Glutamic Acid; Granulocytes; Monoamine Oxidase; Neurotoxins; Osmolar Concentration; Time Factors | 1989 |
Calcium binding to the isolated beta-hydroxyaspartic acid-containing epidermal growth factor-like domain of bovine factor X.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Calcium; Cattle; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Factor X; Kinetics; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Protein Binding; Protein Conformation; Trypsin | 1989 |
Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.
Topics: Asparagine; Aspartic Acid; Chromatography, High Pressure Liquid; Complement Activating Enzymes; Complement C1; Complement C1r; Complement C1s; Epidermal Growth Factor; Gas Chromatography-Mass Spectrometry; Humans; Mucoproteins; Protein Processing, Post-Translational; Sequence Homology, Nucleic Acid; Uromodulin | 1987 |
beta-Hydroxyaspartic acid or beta-hydroxyasparagine in bovine low density lipoprotein receptor and in bovine thrombomodulin.
Topics: Adrenal Glands; Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Cattle; Epidermal Growth Factor; Molecular Sequence Data; Receptors, Cell Surface; Receptors, LDL; Receptors, Thrombin; Sequence Homology, Nucleic Acid | 1988 |
Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.
Topics: Animals; Aspartic Acid; Corpus Striatum; Female; Glutamates; Glutamic Acid; Kainic Acid; Rats; Rats, Inbred Strains | 1985 |
Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds.
Topics: Animals; Aspartic Acid; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Kainic Acid; Oxadiazoles; Quisqualic Acid; Synaptic Transmission | 1985 |
Na+-dependent "binding" of D-aspartate in brain membranes is largely due to uptake into membrane-bounded saccules.
Topics: Animals; Aspartic Acid; Brain; Carrier Proteins; Cell Membrane; Freezing; Glutamates; Glutamic Acid; Hot Temperature; Kinetics; Osmolar Concentration; Rats; Sodium; Synaptic Membranes | 1986 |
Potentiation by kainate of excitatory amino acid release in striatum: complementary in vivo and in vitro experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Corpus Striatum; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Potassium; Rats; Rats, Inbred Strains; Taurine; Tetrodotoxin | 1988 |
Continuous glutamate leakage from brain cells is balanced by compensatory high-affinity reuptake transport.
Topics: Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin | 1987 |
The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Carboxylic Acids; Codon; Dogs; Epidermal Growth Factor; Factor IX; Factor IXa; Humans; Macromolecular Substances; Molecular Sequence Data; Mutation; Protein Processing, Post-Translational; Serine Endopeptidases | 1988 |
Protein C in bovine plasma after warfarin treatment. Purification, partial characterization, and beta-hydroxyaspartic acid content.
Topics: Animals; Aspartic Acid; Blood Coagulation Factors; Cattle; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Molecular Weight; Protein C; Warfarin | 1985 |
Calcium binding to a human factor IXa derivative lacking gamma-carboxyglutamic acid: evidence for two high-affinity sites that do not involve beta-hydroxyaspartic acid.
Topics: 1-Carboxyglutamic Acid; Amino Acids; Aspartic Acid; Binding Sites; Calcium; Chromatography, Ion Exchange; Factor IX; Factor IXa; Glutamates; Humans; Time Factors | 1985 |
Binding of iron by factor IX. Possible role for beta-hydroxyaspartic acid.
Topics: Animals; Aspartic Acid; Binding Sites; Cattle; Factor IX; Factor X; Iron; Kinetics; Protein Binding; Prothrombin; Spectrometry, Fluorescence; Spectrophotometry | 1986 |
Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebellum; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hypoxia; In Vitro Techniques; Kinetics; Male; Neurotransmitter Agents; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1983 |
Beta-hydroxyaspartic acid in vitamin K-dependent proteins.
Topics: Amino Acids; Animals; Aspartic Acid; Cattle; Complement System Proteins; Factor IX; Factor X; Humans; Hydrolysis; Male; Proteins; Prothrombin; Vitamin K | 1983 |
The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Blood Coagulation Factors; Cattle; Factor IX; Factor VII; Factor X; Glycoproteins; Humans; Peptide Fragments; Protein C; Prothrombin; Vitamin K | 1983 |
erythro-beta-Hydroxyaspartic acid in bovine factor IX and factor X.
Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Cyanogen Bromide; Factor IX; Factor X; Peptide Fragments; Phenylthiohydantoin; Protein Processing, Post-Translational; Trypsin | 1984 |
Beta-hydroxyaspartic acid in vitamin K-dependent plasma proteins from scorbutic and warfarin-treated guinea pigs.
Topics: 1-Carboxyglutamic Acid; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Aspartic Acid; Blood Coagulation; Blood Proteins; Guinea Pigs; Hydroxylation; Protein Processing, Post-Translational; Vitamin K; Warfarin | 1984 |
Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Aspartic Acid; Factor X; Humans; Macromolecular Substances; Magnetic Resonance Spectroscopy; Mass Spectrometry; Peptide Fragments; Prothrombin | 1983 |
Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate.
Topics: Animals; Aspartic Acid; Cats; Drug Synergism; Electric Conductivity; Glutamates; Neurons; Spinal Cord; Stereoisomerism; Structure-Activity Relationship | 1980 |
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cya
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Autoradiography; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Kainic Acid; Neurotransmitter Uptake Inhibitors; Prosencephalon; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1995 |
Cone photoreceptors respond to their own glutamate release in the tiger salamander.
Topics: Ambystoma; Animals; Aspartic Acid; Calcium; Chloride Channels; Exocytosis; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Picrotoxin; Retinal Cone Photoreceptor Cells; Synapses; Synaptic Transmission; Time Factors | 1995 |
Reaction of aspartate aminotransferase with L-erythro-3-hydroxyaspartate: involvement of Tyr70 in stabilization of the catalytic intermediates.
Topics: Amino Acid Sequence; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Calorimetry; Catalysis; Enzyme Stability; Escherichia coli; Hydrogen Bonding; Kinetics; Protein Conformation; Quinones; Spectrophotometry; Tyrosine | 1995 |
The glutamate uptake regulatory protein (Grp) of Zymomonas mobilis and its relation to the global regulator Lrp of Escherichia coli.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Base Sequence; Biological Transport; Carrier Proteins; Cloning, Molecular; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Gene Dosage; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Genetic Complementation Test; Glutamic Acid; Leucine-Responsive Regulatory Protein; Molecular Sequence Data; Operon; Regulon; Restriction Mapping; Sequence Homology, Amino Acid; Symporters; Transcription Factors; Zymomonas | 1995 |
Effects of a glutamate uptake inhibitor on glutamate release induced by veratridine and ischemia.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Brain Ischemia; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Veratridine | 1995 |
Other lipopeptides.
Topics: Aspartic Acid; Bacterial Proteins; Peptide Biosynthesis; Peptides; Pseudomonas; Threonine | 1995 |
(2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
Topics: Amino Acids, Dicarboxylic; Animals; Anti-Bacterial Agents; Asparagine; Aspartic Acid; Astrocytes; Cell Membrane; Cells, Cultured; Depression, Chemical; Female; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Neuroglia; Neurons; Pregnancy; Rats; Rats, Wistar; Stereoisomerism; Synaptosomes | 1993 |
Glucose can fuel glutamate uptake in ischemic brain.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Ischemia; Glucose; Glutamates; Glutamic Acid; Male; Microdialysis; Osmolar Concentration; Rats; Rats, Sprague-Dawley | 1994 |
Depolarization elicits, while hyperpolarization blocks uptake of endogenous glutamate by retinal horizontal cells of the turtle.
Topics: Aminooxyacetic Acid; Animals; Aspartic Acid; Calcium; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Kainic Acid; Neurotransmitter Uptake Inhibitors; Photoreceptor Cells; Pipecolic Acids; Retina; Turtles | 1993 |
Na(+)-dependent high affinity uptake of L-glutamate in primary cultures of human fibroblasts isolated from three different types of tissue.
Topics: Aspartic Acid; Biological Transport; Cells, Cultured; Dicarboxylic Acids; Fibroblasts; Glutamates; Glutamic Acid; Humans; Kinetics; Muscles; Peripheral Nerves; Pyrrolidines; Skin; Sodium; Tritium | 1994 |
Glial contributions to excitatory neurotransmission in cultured hippocampal cells.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cells, Cultured; Electrophysiology; Glutamates; Glutamic Acid; Glycoproteins; Hippocampus; Lithium; Neuroglia; Neurotransmitter Agents; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1994 |
The Na(+)-dependent binding of [3H]L-aspartate in thaw-mounted sections of rat forebrain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Autoradiography; Dicarboxylic Acids; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Neurotransmitter Uptake Inhibitors; Presynaptic Terminals; Prosencephalon; Pyrrolidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Sodium | 1994 |
Block of glutamate transporters potentiates postsynaptic excitation.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glycoproteins; Hippocampus; In Vitro Techniques; Ion Channel Gating; Lithium; Rats; Receptors, AMPA; Synapses; Synaptic Transmission; Temperature | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate.
Topics: Analysis of Variance; Animals; Aspartic Acid; Biological Transport; Cerebellum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Male; Organ Specificity; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium; Spinal Cord; Stereoisomerism | 1994 |
Pre- and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycemia in cortical cultures.
Topics: Animals; Aspartic Acid; Benzopyrans; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cromakalim; Diazoxide; Embryo, Mammalian; Glutamates; Hypoglycemia; Kainic Acid; Kinetics; L-Lactate Dehydrogenase; Neurons; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 1994 |
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Biological Transport, Active; Choline O-Acetyltransferase; Disease Models, Animal; Glutamates; Lumbosacral Region; Motor Neurons; Organ Culture Techniques; Pyrrolidonecarboxylic Acid; Rats; Receptors, Glutamate; Spinal Cord; Synaptic Transmission | 1993 |
Microdialysis as a tool for in vivo investigation of glutamate transport capacity in rat brain.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Brain Chemistry; Cell Membrane Permeability; Diffusion; Extracellular Space; Male; Microdialysis; Microinjections; Rats; Rats, Wistar | 1995 |
Noise analysis of the glutamate-activated current in photoreceptors.
Topics: Ambystoma; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport, Active; Biophysical Phenomena; Biophysics; Carrier Proteins; Chloride Channels; Electric Conductivity; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Kinetics; Ligands; Mathematics; Models, Biological; Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Sodium; Symporters | 1996 |
Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.
Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Characterization of recombinant human coagulation factor XFriuli.
Topics: 1-Carboxyglutamic Acid; Aspartic Acid; Base Sequence; Binding Sites; Cell Line; DNA, Complementary; Enzyme Activation; Factor X; Hemorrhagic Disorders; Humans; Hydrogen Bonding; Kidney; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Proline; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Serine; Transfection | 1996 |
Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Benzothiadiazines; Calcium; Cells, Cultured; Cycloleucine; Evoked Potentials; Glutamic Acid; Hippocampus; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Virulence Factors, Bordetella; Wheat Germ Agglutinins | 1996 |
Autoradiographic studies indicate regional variations in the characteristics of L-glutamate transporters in the rat brain.
Topics: Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Autoradiography; Binding Sites; Biological Transport; Brain Chemistry; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Male; Neostriatum; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Tritium | 1996 |
The mechanisms controlling physiologically stimulated changes in rat brain glucose and lactate: a microdialysis study.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aspartic Acid; Astrocytes; Brain Chemistry; Cerebrovascular Circulation; Electrodes, Implanted; Glucose; Glycogen; Hydrogen-Ion Concentration; Isoproterenol; Lactic Acid; Male; Microdialysis; Propranolol; Rats; Rats, Sprague-Dawley | 1996 |
Glutamate transport modulation of paracellular permeability across LLC-PK1-F+ monolayers.
Topics: Animals; Aspartic Acid; Cell Membrane Permeability; Epithelium; gamma-Glutamyltransferase; Glucose; Glutamic Acid; Glutamine; Isoxazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Models, Biological; Rabbits; Swine | 1996 |
Aspartate aminotransferase complexed with erythro-beta-hydroxyaspartate: crystallographic and spectroscopic identification of the carbinolamine intermediate.
Topics: Animals; Anti-Bacterial Agents; Aspartate Aminotransferases; Aspartic Acid; Binding Sites; Chickens; Crystallography, X-Ray; Models, Molecular; Protein Conformation; Stereoisomerism | 1996 |
Stimulated release of lactate in freely moving rats is dependent on the uptake of glutamate.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Corpus Striatum; Dicarboxylic Acids; Extracellular Space; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Grooming; Hippocampus; Lactic Acid; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Sprague-Dawley; Symporters | 1997 |
Short-lived intermediates in aspartate aminotransferase systems.
Topics: Aspartate Aminotransferases; Aspartic Acid; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Protein Binding; Thermodynamics | 1997 |
Transporters buffer synaptically released glutamate on a submillisecond time scale.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamic Acid; Hippocampus; Kinetics; Kynurenic Acid; Lithium; Models, Neurological; Neurons; Quinoxalines; Rats; Receptors, AMPA; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 1997 |
Inhibition of glutamate uptake causes an acute increase in aqueous humor protein.
Topics: Alanine; Animals; Aqueous Humor; Aspartic Acid; Biological Transport; Cell Membrane Permeability; Excitatory Amino Acid Antagonists; Eye Proteins; Female; Glutamic Acid; Glutamine; Male; Rabbits | 1997 |
Postsynaptic glutamate transport at the climbing fiber-Purkinje cell synapse.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Dicarboxylic Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; In Vitro Techniques; Kinetics; Nerve Fibers; Oocytes; Patch-Clamp Techniques; Purkinje Cells; Pyrrolidines; Rats; Receptors, AMPA; Receptors, Glutamate; Symporters; Synapses; Synaptic Transmission; Xenopus | 1997 |
Intracerebral microdialysis study of glutamate reuptake in awake, behaving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Bacterial Agents; Aspartic Acid; Behavior, Animal; Carbon Radioisotopes; Consciousness; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mannitol; Microdialysis; Norepinephrine; Parietal Lobe; Phentolamine; Phenylephrine; Rats; Rats, Sprague-Dawley; Sympatholytics; Sympathomimetics; Synaptic Transmission; Tritium | 1997 |
AMPA receptor-mediated slow neuronal death in the rat spinal cord induced by long-term blockade of glutamate transporters with THA.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Cell Death; Glutamic Acid; Hindlimb; Infusions, Parenteral; Injections, Spinal; Male; Motor Activity; Neurons; Paralysis; Rats; Rats, Wistar; Receptors, AMPA; Spinal Cord; Subarachnoid Space; Tail; Time Factors; Urinary Incontinence | 1997 |
DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Cloning, Molecular; COS Cells; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Excitatory Amino Acids; Humans; Oocytes; Receptors, Neurotransmitter; Structure-Activity Relationship; Transfection; Xenopus laevis | 1998 |
Modulation of human glutamate transporter activity by phorbol ester.
Topics: Amino Acid Transport System X-AG; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamates; Glutamic Acid; Humans; Kainic Acid; Kinetics; Phorbol Esters; Protein Kinase C; Retinoblastoma; Staurosporine; Tumor Cells, Cultured | 1998 |
Action of excitatory amino acids on hypodermis and the motornervous system of Ascaris suum: pharmacological evidence for a glutamate transporter.
Topics: Amino Acid Transport System X-AG; Animals; Ascaris suum; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport, Active; Calcium; Dose-Response Relationship, Drug; Electric Conductivity; Epithelium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Microelectrodes; Motor Neurons; Quinoxalines; Sodium | 1998 |
Motor neuron degeneration is attenuated in bax-deficient neurons in vitro.
Topics: Animals; Aspartic Acid; Astrocytes; bcl-2-Associated X Protein; Cell Death; Cell Division; Cell Nucleus; Cell Size; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Female; Genotype; Kainic Acid; Male; Mice; Motor Neurons; Nerve Degeneration; Paraquat; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Spinal Cord; Superoxides | 1999 |
Trans-inhibition of glutamate transport prevents excitatory amino acid-induced glycolysis in astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Anti-Bacterial Agents; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport, Active; Cerebral Cortex; Deoxyglucose; Excitatory Amino Acids; Glucose; Glycolysis; Kinetics; Mice; Phosphorylation; Stereoisomerism | 1999 |
SNARE protein-dependent glutamate release from astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Anti-Bacterial Agents; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Botulinum Toxins; Botulinum Toxins, Type A; Calcium; Cells, Cultured; Coculture Techniques; Dicarboxylic Acids; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Kainic Acid; Macrolides; Membrane Potentials; Membrane Proteins; Nerve Tissue Proteins; Neurons; Proton-Translocating ATPases; Pyrrolidines; Rats; SNARE Proteins; Vesicular Transport Proteins | 2000 |
Metabotropic glutamate receptors and blockade of glial Krebs cycle depress glycinergic synaptic currents of mouse hypoglossal motoneurons.
Topics: Animals; Animals, Newborn; Aspartic Acid; Citric Acid Cycle; Cycloleucine; Cyclopropanes; Excitatory Postsynaptic Potentials; Female; Glycine; Hypoglossal Nerve; Male; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred Strains; Motor Neurons; Neuroglia; Neuroprotective Agents; Patch-Clamp Techniques; Propionates; Receptors, Metabotropic Glutamate; Synapses | 2000 |
Transient treatments with L-glutamate and threo-beta-hydroxyaspartate induce swelling of rat cultured astrocytes.
Topics: 3-O-Methylglucose; Animals; Aspartic Acid; Astrocytes; Cell Nucleus; Cell Size; Cells, Cultured; Cytoplasm; Glutamic Acid; Kinetics; Quisqualic Acid; Rats; Rats, Inbred WKY | 2000 |
Control of synaptic depression by glutamate transporters.
Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission | 2000 |
Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Biological Transport; Dicarboxylic Acids; Diuretics; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Neurotransmitter Uptake Inhibitors; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Chloride Symporter Inhibitors; Somatosensory Cortex; Synaptic Transmission; Thalamus | 2000 |
Na+-dependent high-affinity glutamate transport in macrophages.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Humans; Intracellular Fluid; Ion Transport; Macaca fascicularis; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Monocytes; Pyrrolidines; Sodium; Symporters; Tumor Necrosis Factor-alpha | 2000 |
Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Drug Synergism; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synapses; Synaptic Transmission; Theophylline | 2000 |
[Dopamine-dependent inhibition of glycine release in the rat nucleus accumbens during feeding].
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Feeding Behavior; Glutamic Acid; Glycine; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2000 |
Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Aspartic Acid; Benzodiazepines; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Hippocampus; Male; Microdialysis; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Seizures | 2000 |
3-Nitropropionic acid neurotoxicity in organotypic striatal and corticostriatal slice cultures is dependent on glucose and glutamate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glucose; Glutamate Decarboxylase; Glutamic Acid; Huntington Disease; In Vitro Techniques; Mitochondria; Nitro Compounds; Propionates; Rats; Succinate Dehydrogenase; Tetrodotoxin | 2000 |
Müller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity.
Topics: Animals; Aspartic Acid; Biomarkers; Cell Survival; Cells, Cultured; Coculture Techniques; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Neuroglia; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Rats; Rats, Long-Evans; Retinal Ganglion Cells | 2000 |
Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Kainic Acid; Neuroglia; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Symporters; Time Factors; Tritium | 2001 |
Possible linkage between glutamate transporter and mitogen-activated protein kinase cascade in cultured rat cortical astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurotransmitter Uptake Inhibitors; Phosphorylation; Pyrrolidines; Rats; Rats, Wistar; Receptors, Glutamate; Signal Transduction | 2001 |
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzofurans; Binding, Competitive; Cells, Cultured; Dicarboxylic Acids; Dose-Response Relationship, Drug; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Intracellular Fluid; Kainic Acid; Mice; Neurotransmitter Uptake Inhibitors; Protein Isoforms; Pyrrolidines; Sodium; Stereoisomerism | 2001 |
Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.
Topics: Ammonia; Animals; Aspartic Acid; Cell Line; Cytosol; Extracellular Space; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Intracellular Fluid; Kidney Tubules, Proximal; Kinetics; Mitochondria; Models, Chemical; Nitrogen Isotopes; Stereoisomerism | 2001 |
Release of D,L-threo-beta-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Excitatory Amino Acids; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetanus Toxin | 2001 |
Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Antioxidants; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Catalase; Cattle; Cells, Cultured; Chromans; Cyclic N-Oxides; Dinitrobenzenes; Dithiothreitol; Hydrogen Peroxide; Methylmercury Compounds; Nerve Tissue Proteins; Nitrogen Oxides; Oxidants; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reducing Agents; RNA, Messenger; Spin Labels | 2001 |
A Na+-dependent electrogenic glutamate transporter current in voltage-clamped cells of corpora allata in the cricket Gryllus bimaculatus.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Corpora Allata; Electric Conductivity; Electrophysiology; Excitatory Amino Acid Agonists; Glutamic Acid; Gryllidae; Male; Patch-Clamp Techniques; Receptors, Glutamate; Sodium; Substrate Specificity | 2001 |
Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Central Nervous System Stimulants; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Kinetics; Organ Culture Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Kainic Acid; Synapses; Synaptic Transmission; Temperature; Thalamus | 2001 |
Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Carrier Proteins; Cells, Cultured; Central Nervous System; Cysteine; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Fetus; Glutathione; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Serine; Sodium | 2001 |
Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5).
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Carrier Proteins; Electrophysiology; Glutamate Plasma Membrane Transport Proteins; Oocytes; Receptors, Glutamate; Symporters; Xenopus | 2001 |
Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal.
Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cells, Cultured; Dicarboxylic Acids; Glutamic Acid; Kainic Acid; Mice; Nerve Tissue Proteins; Neurons; Prosencephalon; Pyrrolidines; Substrate Specificity | 2001 |
gamma-glutamate and beta-hydroxyaspartate in proteins.
Topics: Aspartic Acid; Chromatography, High Pressure Liquid; Glutamic Acid; Proteins | 2002 |
Inhibitor of glutamate transport alters synaptic transmission at sensorimotor synapses in Aplysia.
Topics: Action Potentials; Animals; Aplysia; Aspartic Acid; Excitatory Postsynaptic Potentials; Glutamic Acid; Motor Neurons; Neural Inhibition; Neurons, Afferent; Synaptic Transmission | 2002 |
Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.
Topics: Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biological Transport; Biotinylation; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Membrane Potentials; Membrane Proteins; Patch-Clamp Techniques; Peptide Fragments; Rats; Synapses; Synaptic Transmission | 2002 |
Feeding-induced decrease in extracellular glutamate level in the rat nucleus accumbens: dependence on glutamate uptake.
Topics: Analysis of Variance; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine Antagonists; Eating; Extracellular Space; Feeding Behavior; Glutamic Acid; Male; Microdialysis; Neurotransmitter Uptake Inhibitors; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter.
Topics: 2-Chloroadenosine; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport; Calcium; Cell Differentiation; Cells, Cultured; Cycloheximide; Dicarboxylic Acids; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Protein Synthesis Inhibitors; Purines; Pyrrolidines; Symporters; Up-Regulation | 2002 |
Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain Mapping; Catalepsy; Cell Count; Coloring Agents; Locomotion; Male; Malonates; Muscle Rigidity; Nerve Degeneration; Neurons; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2002 |
Involvement of acetylated tubulin in the regulation of Na+,K+ -ATPase activity in cultured astrocytes.
Topics: Acetylation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Astrocytes; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Ionophores; Mice; Monensin; N-Methylaspartate; Sodium-Potassium-Exchanging ATPase; Tubulin | 2003 |
Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Communication; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neuroglia; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sodium; Synaptic Transmission | 2003 |
The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Binding, Competitive; Biological Transport; Cells, Cultured; Cerebral Cortex; Cysteine; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Kainic Acid; Mice; Neurons; Sodium; Symporters | 2003 |
Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Feedback, Physiological; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Membrane Potentials; Neural Inhibition; Neurons; Osmolar Concentration; Patch-Clamp Techniques; Presynaptic Terminals; Pyramidal Cells; Rats; Synapses; Synaptic Transmission | 2003 |
Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.
Topics: Amino Acid Transport System X-AG; Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Cell Death; Cell Survival; Cerebellar Diseases; Disease Models, Animal; Glyburide; Ischemic Preconditioning; Isoflurane; Male; Nerve Degeneration; Organ Culture Techniques; Organophosphonates; Potassium Channel Blockers; Purkinje Cells; Rats; Rats, Sprague-Dawley | 2003 |
Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina.
Topics: Animals; Aspartic Acid; Carps; Color; D-Aspartic Acid; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Interneurons; Membrane Potentials; Photic Stimulation; Picrotoxin; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells | 2003 |
Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Aspartic Acid; Astrocytes; Calcium Channel Blockers; Cobalt; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium Channel Blockers; Tetraethylammonium; Tetrodotoxin | 2003 |
A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Cloning, Molecular; Fructose-Bisphosphate Aldolase; Hydrogen-Ion Concentration; Molecular Sequence Data; Molecular Weight; Paracoccus denitrificans; Substrate Specificity; Temperature | 2003 |
Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity.
Topics: Aspartic Acid; Cations, Divalent; Drug Resistance, Fungal; Edetic Acid; Enzyme Inhibitors; Escherichia coli; Hydro-Lyases; Hydroxylamine; Molecular Weight; Mutagenesis, Insertional; Racemases and Epimerases; Recombinant Proteins; Saccharomyces cerevisiae; Serine; Spectrum Analysis; Stereoisomerism; Substrate Specificity; Transformation, Genetic | 2003 |
beta-Hydroxyaspartic acid: synthesis and separation of its diastereoisomers.
Topics: Aspartic Acid | 1960 |
DIASTEREOISOMERS OF BETA-HYDROXYASPARTIC ACID AS ASPARTIC ACID ANTAGONISTS IN BACTERIA.
Topics: Antimetabolites; Aspartic Acid; Bacteria; Chemistry Techniques, Analytical; Escherichia coli; Leuconostoc; Pharmacology; Research | 1963 |
FURTHER STUDIES ON BETA-HYDROXYASPARTIC ACID.
Topics: Aspartic Acid; Chemistry Techniques, Analytical; Glycine; Protein Hydrolysates; Research | 1964 |
GLUTAMIC-ASPARTIC TRANSAMINASE. VII. EQUILIBRIUM KINETICS WITH ERYTHRO-BETA-HYDROXYASPARTIC ACID.
Topics: Amino Acids; Aspartate Aminotransferases; Aspartic Acid; Catalysis; Enzyme Inhibitors; Glutarates; Kinetics; Malates; Maleates; Pyridines; Research; Spectrophotometry; Succinates; Tartrates | 1964 |
Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Corpus Striatum; Dopamine; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycine; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Symporters; Synaptic Transmission | 2003 |
Identification of glutamate transporters and receptors in mouse testis.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Cells, Cultured; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; GluK2 Kainate Receptor; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Symporters; Synaptosomes; Testis | 2004 |
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses | 2004 |
Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Cell Line; Cerebellum; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Green Fluorescent Proteins; Humans; In Vitro Techniques; Membrane Potentials; Microinjections; Microscopy, Fluorescence, Multiphoton; Oocytes; Patch-Clamp Techniques; Purkinje Cells; Rats; Sodium; Transfection; Tritium; Xenopus | 2005 |
Effects of the inhibitors on glutamate uptake by nerve terminals after exposure of rats to centrifuge-induced hypergravity.
Topics: Animals; Aspartic Acid; Biological Transport; Centrifugation; Dose-Response Relationship, Drug; Glutamic Acid; Hypergravity; Male; Rats; Rats, Wistar; Synaptosomes | 2004 |
Tryptophan breakdown pathway in bipolar mania.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brief Psychiatric Rating Scale; Female; Gyrus Cinguli; Humans; Kynurenic Acid; Kynurenine; Male; Schizophrenia; Severity of Illness Index; Tryptophan | 2007 |
A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid.
Topics: Amination; Aspartic Acid; Cinnamates; Hydroxylation; Molecular Structure; Stereoisomerism | 2008 |
Genome-scale analysis of anti-metabolite directed strain engineering.
Topics: Alanine; Algorithms; Antimetabolites; Asparagine; Aspartic Acid; Cloning, Molecular; Contig Mapping; Escherichia coli; Gene Expression Profiling; Gene Frequency; Genetic Engineering; Genome, Bacterial; Genomic Library; Genomics; Lac Operon; Mutagenesis, Insertional; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Phenotype; Plasmids; Selection, Genetic | 2008 |
Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid.
Topics: Aspartic Acid; Base Sequence; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; DNA Primers; Hydroxylation; Mass Spectrometry; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Protein Engineering; Stereoisomerism; Substrate Specificity | 2008 |
Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
Topics: Alkaloids; Animals; Apoptosis; Aspartic Acid; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Drug Interactions; Enzyme Inhibitors; Hydrogen Peroxide; Ionophores; Motor Neurons; Neuroprotective Agents; Organ Culture Techniques; Oxidants; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Spinal Cord; Staurosporine; Thapsigargin | 2008 |
Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.
Topics: Animals; Aspartic Acid; Biomarkers; Blood Platelets; Brain; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Gravity, Altered; Kinetics; Male; Rats; Rats, Wistar; Sodium; Synaptosomes | 2007 |
gamma-Glutamate and beta-hydroxyaspartate in proteins.
Topics: Adsorption; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Glutamic Acid; Humans; Membrane Lipids; Phospholipids; Proteins | 2008 |
Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cation Transport Proteins; Deferoxamine; Ferritins; Glutamic Acid; Immunoblotting; Immunohistochemistry; In Vitro Techniques; Iron; Iron Chelating Agents; L-Lactate Dehydrogenase; Lipid Peroxidation; Motor Neurons; Nerve Degeneration; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Spinal Cord | 2009 |
Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Cell Death; Cells, Cultured; Competitive Bidding; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamic Acid; Neurons; Neuroprotective Agents; PC12 Cells; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Tetrazolium Salts; Thiamine Deficiency; Thiazoles | 2009 |
Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Caspase 12; Cell Death; Cell Survival; Disease Models, Animal; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Mice; Mice, Transgenic; Motor Neurons; Organ Culture Techniques; Spinal Cord; Superoxide Dismutase | 2009 |
Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study.
Topics: Amyotrophic Lateral Sclerosis; Animals; Aspartic Acid; Cell Membrane; Cytoplasm; Endoplasmic Reticulum; Erythropoietin; Nerve Degeneration; Neurons; Neuropil; Neuroprotective Agents; Organ Culture Techniques; Rats; Spinal Cord; Vacuoles | 2010 |
Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.
Topics: Aspartic Acid; Bacterial Proteins; Carboxy-Lyases; Hydrostatic Pressure; Kinetics; Mutation; Protein Conformation; Pseudomonas; Pyridoxal Phosphate; Spectrophotometry; Stereoisomerism; Succinic Acid | 2010 |
Neuroprotective effect of CPDT on THA-induced cortical motor neuron death in an organotypic culture model.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Bacterial Toxins; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Heme Oxygenase-1; Motor Cortex; Motor Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Organ Culture Techniques; Rats | 2010 |
A practical synthesis of N α-Fmoc protected L-threo-β-hydroxyaspartic acid derivatives for coupling via α- or β-carboxylic group.
Topics: Aspartic Acid; Molecular Structure; Stereoisomerism | 2012 |
Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.
Topics: Animals; Arthritis; Aspartic Acid; Disease Models, Animal; Enzyme Inhibitors; Pain; Racemases and Epimerases; Rats; Serine | 2012 |
Astrocytes release D-serine by a large vesicle.
Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Calcium; Cytoplasmic Vesicles; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exocytosis; Female; Glycine; Hippocampus; In Vitro Techniques; Male; Microscopy, Electron, Transmission; Patch-Clamp Techniques; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Serine; Valine | 2013 |
Isolation and structures of pipecolidepsins A and B, cytotoxic cyclic depsipeptides from the Madagascan sponge Homophymia lamellosa.
Topics: Animals; Aspartic Acid; Depsipeptides; Drug Screening Assays, Antitumor; Glutamine; Humans; Madagascar; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Porifera | 2014 |
Cerebellar fastigial nuclear glutamatergic neurons regulate immune function via hypothalamic and sympathetic pathways.
Topics: Animals; Aspartic Acid; Axons; Cerebellar Nuclei; Diazooxonorleucine; Enzyme Inhibitors; Female; Glutamic Acid; Glutaminase; Hypothalamic Area, Lateral; Hypothalamus; Immunity; Injections; Killer Cells, Natural; Male; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; T-Lymphocytes; Thalamus | 2015 |
Structural insights into the substrate stereospecificity of D-threo-3-hydroxyaspartate dehydratase from Delftia sp. HT23: a useful enzyme for the synthesis of optically pure L-threo- and D-erythro-3-hydroxyaspartate.
Topics: Aspartic Acid; Catalytic Domain; Crystallography, X-Ray; Delftia; Hydro-Lyases; Models, Molecular; Protein Conformation; Substrate Specificity | 2015 |
One-Pot Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3(2).
Topics: Aspartic Acid; Escherichia coli; Hydrolysis; Hydroxylation; Metabolic Engineering; Mixed Function Oxygenases; Recombinant Proteins; Streptomyces coelicolor | 2015 |
EAAT and Xc⁻ Exchanger Inhibition Depletes Glutathione in the Transformed Human Lens Epithelial Cell Line SRA 01/04.
Topics: Amino Acid Transport System y+; Aspartic Acid; Blotting, Western; Cell Line, Transformed; Dose-Response Relationship, Drug; Epithelial Cells; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutathione; Humans; Kainic Acid; Lens, Crystalline | 2016 |
Isolation and amino acid sequence of a dehydratase acting on d-erythro-3-hydroxyaspartate from Pseudomonas sp. N99, and its application in the production of optically active 3-hydroxyaspartate.
Topics: Amino Acid Sequence; Aspartic Acid; Bacterial Proteins; Cloning, Molecular; Escherichia coli; Gene Expression; Hydro-Lyases; Kinetics; Optical Rotation; Oxaloacetic Acid; Protein Binding; Pseudomonas; Recombinant Proteins; Saccharomyces cerevisiae; Schizosaccharomyces; Sequence Alignment; Sequence Homology, Amino Acid; Stereoisomerism; Substrate Specificity | 2017 |
Optical measurement of glutamate in slice preparations of the mouse retina.
Topics: Animals; Aspartic Acid; Cadmium Compounds; Calcium Channel Blockers; Enzyme-Linked Immunosorbent Assay; GABA Antagonists; Glutamic Acid; Mice; Mice, Inbred C57BL; Picrotoxin; Potassium; Retina; Retinal Ganglion Cells; Spectrometry, Fluorescence; Strychnine; Synapses; Vesicular Glutamate Transport Proteins | 2018 |
Derivatization reagent-assisted enantioseparation of 3-hydroxyaspartate with two chiral centers in rat cerebrospinal fluid by capillary electrophoresis-mass spectrometry.
Topics: Animals; Aspartic Acid; Electrophoresis, Capillary; Fluorenes; Limit of Detection; Mass Spectrometry; Rats; Stereoisomerism | 2019 |
Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle.
Topics: Alcohol Oxidoreductases; Aldehyde-Lyases; Aquatic Organisms; Aspartic Acid; Biocatalysis; Glycolates; Glyoxylates; Hydro-Lyases; Kinetics; Metabolic Networks and Pathways; Oxidoreductases; Phytoplankton; Proteobacteria; Transaminases | 2019 |
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation-Mediated Cyclization and Absolute Structure Establishment.
Topics: Aspartic Acid; Cyclization; Lipopeptides; Molecular Structure; Peptides, Cyclic; Solid-Phase Synthesis Techniques; Stereoisomerism | 2020 |
Separation and determination of 3-hydroxyaspartate by online concentration capillary electrophoresis/laser-induced fluorescence with microwave-assisted derivatization.
Topics: Aspartic Acid; Chemical Fractionation; Electrophoresis, Capillary; Linear Models; Microwaves; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2021 |