Compounds > 3-hydroxyamino-1-methyl-5h-pyrido(4-3-b)indole

3-hydroxyamino-1-methyl-5h-pyrido(4-3-b)indole and 2-amino-6-methyldipyrido(1-2-a-3--2--d)imidazole

3-hydroxyamino-1-methyl-5h-pyrido(4-3-b)indole has been researched along with 2-amino-6-methyldipyrido(1-2-a-3--2--d)imidazole* in 1 studies

Other Studies

1 other study(ies) available for 3-hydroxyamino-1-methyl-5h-pyrido(4-3-b)indole and 2-amino-6-methyldipyrido(1-2-a-3--2--d)imidazole

Article	Year
DNA binding of N-hydroxy-Trp-P-2 and N-hydroxy-Glu-P-1 by acetyl-CoA dependent enzyme in mammalian liver cytosol. Carcinogenesis, 1985, Volume: 6, Issue:2 3-Hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, active metabolites of protein pyrolysate carcinogens, were further activated to DNA-binding species by an acetyl-CoA dependent enzyme in hepatic cytosol. This activity was supported also by N-hydroxy-2-acetylaminofluorene instead of acetyl-CoA, and it was inhibited by iodoacetamide and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) but not by diethyl-p-nitrophenylphosphate. The activity was observed in the cytosols of rats, mice and rapid acetylator rabbits, which possessed N-acetylation activity of 2-aminofluorene and Trp-P-2. On the other hand, the activity could not be detected in the cytosols of a dog and a slow acetylator rabbit. Topics: Acetyl Coenzyme A; Acetylation; Animals; Carbolines; Cytosol; DNA; Imidazoles; In Vitro Techniques; Indoles; Liver; Mice; Mutagens; Rabbits; Rats; Species Specificity	1985

Article

Year

DNA binding of N-hydroxy-Trp-P-2 and N-hydroxy-Glu-P-1 by acetyl-CoA dependent enzyme in mammalian liver cytosol.

Carcinogenesis, 1985, Volume: 6, Issue:2

3-Hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, active metabolites of protein pyrolysate carcinogens, were further activated to DNA-binding species by an acetyl-CoA dependent enzyme in hepatic cytosol. This activity was supported also by N-hydroxy-2-acetylaminofluorene instead of acetyl-CoA, and it was inhibited by iodoacetamide and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) but not by diethyl-p-nitrophenylphosphate. The activity was observed in the cytosols of rats, mice and rapid acetylator rabbits, which possessed N-acetylation activity of 2-aminofluorene and Trp-P-2. On the other hand, the activity could not be detected in the cytosols of a dog and a slow acetylator rabbit.

Topics: Acetyl Coenzyme A; Acetylation; Animals; Carbolines; Cytosol; DNA; Imidazoles; In Vitro Techniques; Indoles; Liver; Mice; Mutagens; Rabbits; Rats; Species Specificity

1985