3-hydroxy-5-estrane-17-carbonitrile and pregnanolone

3-hydroxy-5-estrane-17-carbonitrile has been researched along with pregnanolone in 1 studies

Compound Research Comparison

Studies (3-hydroxy-5-estrane-17-carbonitrile)	Trials (3-hydroxy-5-estrane-17-carbonitrile)	Recent Studies (post-2010) (3-hydroxy-5-estrane-17-carbonitrile)	Studies (pregnanolone)	Trials (pregnanolone)	Recent Studies (post-2010) (pregnanolone)
17	0	2	1,984	111	666

Protein Interaction Comparison

Protein	Taxonomy	pregnanolone (IC50)
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	0.101
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	0.117
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	0.101
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus (Norway rat)	0.117
Sodium- and chloride-dependent GABA transporter 3	Rattus norvegicus (Norway rat)	0.117
Sodium- and chloride-dependent betaine transporter	Rattus norvegicus (Norway rat)	0.117
Gamma-aminobutyric acid receptor subunit alpha-1	Mus musculus (house mouse)	0.071
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	0.101
GABA theta subunit	Rattus norvegicus (Norway rat)	0.101
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	0.101

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Brimelow, BC; Covey, DF; Jagodic, MM; Jevtovic-Todorovic, V; Jiang, X; Krishnan, K; Mennerick, S; Pathirathna, S; Todorovic, SM; Zorumski, CF	1

Other Studies

1 other study(ies) available for 3-hydroxy-5-estrane-17-carbonitrile and pregnanolone

Article	Year
New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain, 2005, Volume: 114, Issue:3 Topics: Anesthetics; Animals; Calcium Channels, T-Type; Estranes; Female; Ganglia, Spinal; Male; Membrane Potentials; Neurons, Afferent; Nitriles; Nociceptors; Oocytes; Pregnanediones; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus	2005

Article

Year

New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.

Pain, 2005, Volume: 114, Issue:3

Topics: Anesthetics; Animals; Calcium Channels, T-Type; Estranes; Female; Ganglia, Spinal; Male; Membrane Potentials; Neurons, Afferent; Nitriles; Nociceptors; Oocytes; Pregnanediones; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenopus

2005