3-hydroxy-3-methylglutaryl-coenzyme a has been researched along with simvastatin in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 13 (41.94) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Himberg, JJ; Jokelainen, K; Laaksonen, R; Sahi, T; Tikkanen, MJ | 1 |
| Cooper, ME; Gilbert, RE; Jerums, G | 1 |
| Hosomi, N; Izumi, Y; Kitadai, M; Satoh, K; Takahashi, T; Tsuda, Y | 1 |
| Murota, S; Sato-Suzuki, I | 1 |
| Kim, KD; Naoumova, RP; Pfohl, M; Thompson, GR | 1 |
| Côté, I; Gaudet, M; Grégoire, JP; Leach, A; Moisan, J; Vaillancourt, R | 1 |
| Adzet, T; Alegret, M; Díaz, C; Hernández, G; Laguna, JC; Peris, C; Sánchez, RM; Vázquez, M; Verd, JC | 1 |
| Jacobson, TA | 1 |
| Aebischer, C; Elste, V; Raederstorff, D; Weber, P | 1 |
| Ma, C; Wang, X; Wei, J | 1 |
| An, CY; Gao, YY; Liu, XM; Sun, YM; Ying, S | 1 |
| Hodgkinson, CP; Ye, S | 1 |
| Eckert, GP; Hooff, GP; Igbavboa, U; Müller, WE; Strandjord, DM; Volmer, DA; Wood, WG | 1 |
| Bababeygy, SR; Hou, LC; Polevaya, NV; Prugpichailers, T; Steinman, L; Sun, A; Tse, V; Veeravagu, A; Xiong, A; Youssef, S | 1 |
| Chang, LC; Chen, JS; Hwang, JC; Lin, YF; Shui, HA | 1 |
| Choi, DH; Choi, JS; Yang, SH | 1 |
| Kundumani-Sridharan, V; Rao, GN; Singh, NK | 1 |
| Jasińska-Stroschein, M; Orszulak-Michalak, D; Owczarek, J | 1 |
| Furuta, T; Ikuma, M; Miyajima, H; Osawa, S; Sugimoto, K; Sugimoto, M; Takayanagi, Y; Yamada, T; Zhang, J | 1 |
| Chen, Y; Li, W; Li, Y; Liu, H; Wang, Z | 1 |
| Cai, DQ; Kim, CS; Kim, DH; Kim, SK; Lee, KJ; Qi, XF; Qin, JW; Wu, Z; Yu, YH; Zheng, L | 1 |
| Baumgarten, G; Frede, S; Hilbert, T; Hoeft, A; Klaschik, S; Knuefermann, P; Poth, J | 1 |
| Ashok, P; Poulose, DN; Singh, D; Suresh, B | 1 |
| Chang, HF; Chang, JK; Chen, HT; Chuang, SC; Feng, CW; Ho, ML; Hsieh, KC; Kao, CL; Wang, GJ; Wen, ZH; Wu, SM | 1 |
| Hwang, IG; Kang, JH; Kang, WK; Kim, ST; Lee, HR; Lee, J; Lee, SC; Lim, HY; Park, JO; Park, KW; Park, SH; Park, YS | 1 |
| Castro, LF; de los Santos, CB; Lopes-Marques, M; Neuparth, T; Ruivo, R; Santos, MM; Torres, T | 1 |
| DeFranco, A; Emelyanova, L; Holmuhamedov, A; Holmuhamedov, E; Jahangir, A; Kress, D; Negmadjanov, U; Rizvi, F; Ross, G; Shi, Y; Siddiqui, R; Tajik, AJ | 1 |
| Bieler, M; Black, KE; Grasberger, P; Hariri, LP; Lin, Y; Medoff, BD; Nichols, R; Nicklin, P; Pantano, L; Probst, CK; Pronzati, G; Santos, DM; Seither, P; Spinney, JJ; Tager, AM; Wyatt, D | 1 |
| Adorni, MP; Biancorosso, N; Bressan, A; Brilli, E; Chen, H; Dall'Acqua, S; Faggin, E; Ferri, N; Lupo, MG; Neutel, C; Rattazzi, M; Salvalaio, M; Sut, S; Tarantino, G; Vivian, G | 1 |
| Lindsay, C; Musgaard, M; Russell, AJ; Sitsapesan, R | 1 |
| Archunan, G; Balraj, J; Dhanapal, AR; Jairaman, K; Jayaraman, A; Kalieswaran, V; Murugesan, T | 1 |
1 review(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and simvastatin
| Article | Year |
|---|---|
"The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline?.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Risk Factors; Simvastatin | 2000 |
3 trial(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and simvastatin
| Article | Year |
|---|---|
Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscles; Simvastatin; Ubiquinone | 1995 |
Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia.
Topics: Acyl Coenzyme A; Blood Viscosity; Cholesterol; Enzyme Inhibitors; Female; Fibrinogen; Hematocrit; Hemorheology; Humans; Hyperlipoproteinemias; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Triglycerides | 1996 |
Simvastatin plus capecitabine-cisplatin versus placebo plus capecitabine-cisplatin in patients with previously untreated advanced gastric cancer: a double-blind randomised phase 3 study.
Topics: Acyl Coenzyme A; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Deoxycytidine; Disease-Free Survival; Double-Blind Method; Female; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Simvastatin; Stomach Neoplasms; Treatment Outcome; Young Adult | 2014 |
27 other study(ies) available for 3-hydroxy-3-methylglutaryl-coenzyme a and simvastatin
| Article | Year |
|---|---|
Primary prevention of stroke.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Arteriosclerosis; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypercholesterolemia; Lovastatin; Meta-Analysis as Topic; Oxidoreductases; Pravastatin; Simvastatin | 1996 |
Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells.
Topics: Acyl Coenzyme A; Animals; Cell Division; Enzyme Inhibitors; Lovastatin; Mevalonic Acid; Neurites; PC12 Cells; Pravastatin; Rats; Simvastatin | 1996 |
Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions.
Topics: Acyl Coenzyme A; Adult; Analysis of Variance; Anticholesteremic Agents; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Meglutol; Mevalonic Acid; Simvastatin | 1998 |
Preferred hydroxymethylglutaryl-coenzyme A reductase inhibitors: treatment-modification program and outcomes.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Canada; Cost-Benefit Analysis; Drug Administration Schedule; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Medical Records; Military Personnel; Simvastatin; Treatment Outcome | 1999 |
Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline-Phosphate Cytidylyltransferase; Enzymes; Heptanoic Acids; Lipids; Lipoprotein Lipase; Lipoproteins, VLDL; Liver; Male; Phospholipids; Pyrroles; Rabbits; Simvastatin; Sterol O-Acyltransferase; Triglycerides | 1999 |
Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters.
Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Antioxidants; Cholesterol; Chromans; Cricetinae; Lipids; Lipoproteins, LDL; Male; Mesocricetus; Random Allocation; Simvastatin; Tocotrienols; Vitamin E | 2002 |
Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 expression of glomerular mesangial cells in hypercholesterolemic rabbits.
Topics: Acyl Coenzyme A; Animals; Cholesterol; Diet, Atherogenic; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Male; Mesangial Cells; Plasminogen Activator Inhibitor 1; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Thromboplastin; Triglycerides | 2006 |
Effect of ScrF I polymorphism in the 2nd intron of the HMGCR gene on lipid-lowering response to simvastatin in Chinese diabetic patients.
Topics: Acyl Coenzyme A; Aged; China; Deoxyribonucleases, Type II Site-Specific; Diabetes Mellitus, Type 2; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Humans; Lipid Metabolism; Lipids; Male; Middle Aged; Polymorphism, Single Nucleotide; Simvastatin | 2007 |
Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression.
Topics: Acyl Coenzyme A; Amides; Anticholesteremic Agents; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Kidney; Leucine; Lipopolysaccharides; NF-kappa B; Pravastatin; Pyridines; Signal Transduction; Simvastatin; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.
Topics: Acyl Coenzyme A; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain; Cholesterol; Farnesyltranstransferase; Frontal Lobe; Geranyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin | 2009 |
HMG-CoA reductase inhibition causes increased necrosis and apoptosis in an in vivo mouse glioblastoma multiforme model.
Topics: Acyl Coenzyme A; Animals; Apoptosis; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Glioblastoma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Necrosis; Neoplasms, Experimental; Neovascularization, Physiologic; Simvastatin | 2009 |
Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.
Topics: Actins; Acyl Coenzyme A; Animals; Cell Division; Endoplasmic Reticulum Chaperone BiP; Glomerular Mesangium; Glucose; Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Glomerulus; Lovastatin; Mice; Pravastatin; Simvastatin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetradecanoylphorbol Acetate | 2010 |
Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Topics: Acyl Coenzyme A; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Injections, Intravenous; Losartan; Lovastatin; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Simvastatin; Tetrazoles; Time Factors | 2011 |
12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation.
Topics: Acyl Coenzyme A; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Cell Movement; Cells, Cultured; Guanine Nucleotide Exchange Factors; Hindlimb; Humans; Hydroxyeicosatetraenoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Mevalonic Acid; Mice; Mice, Knockout; Neovascularization, Physiologic; Neuropeptides; Prenylation; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rho Guanine Nucleotide Exchange Factors; Simvastatin | 2011 |
Concomitant administration of different doses of simvastatin with ivabradine influence on PAI-1 and heart rate in normo- and hypercholesterolaemic rats.
Topics: Acyl Coenzyme A; Animals; Benzazepines; Blood Pressure; Cardiovascular Agents; Cholesterol; Heart Rate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ivabradine; Lipids; Male; Models, Statistical; Plasminogen Activator Inhibitor 1; Rats; Rats, Wistar; Risk Factors; Simvastatin | 2012 |
Statins directly suppress cytokine production in murine intraepithelial lymphocytes.
Topics: Acyl Coenzyme A; Animals; Cell Survival; Cytokines; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Lymphocytes; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Phenotype; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin; Spleen; Time Factors | 2013 |
Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo.
Topics: Acyl Coenzyme A; Adenocarcinoma; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Bone Neoplasms; Cell Proliferation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Simvastatin; Tumor Cells, Cultured | 2013 |
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.
Topics: Acetylcysteine; Acyl Coenzyme A; Animals; Antioxidants; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lymphoma; Membrane Potential, Mitochondrial; Mevalonic Acid; Mice; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2013 |
Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells.
Topics: Acyl Coenzyme A; Angiopoietin-2; Atherosclerosis; Cell Survival; Cells, Cultured; Endothelial Cells; Exocytosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Simvastatin; Weibel-Palade Bodies | 2013 |
Evaluation of antihyperlipidemic potency of a polyherbomineral formulation (AF-LIP) in experimental animal models.
Topics: Acyl Coenzyme A; Animals; Atherosclerosis; Cholesterol; Diet, High-Fat; Dose-Response Relationship, Drug; Feces; Female; Fenofibrate; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Male; Plant Extracts; Polyethylene Glycols; Rats; Rats, Wistar; Simvastatin | 2014 |
A novel anabolic agent: a simvastatin analogue without HMG-CoA reductase inhibitory activity.
Topics: Acyl Coenzyme A; Anabolic Agents; Animals; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Molecular Structure; Osteogenesis; Simvastatin; Solid-Phase Synthesis Techniques; Zebrafish | 2014 |
Statins: An undesirable class of aquatic contaminants?
Topics: Acyl Coenzyme A; Animals; Atorvastatin; Binding Sites; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Molecular Docking Simulation; Protein Structure, Tertiary; Simvastatin; Water Pollutants, Chemical | 2016 |
Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin.
Topics: Acyl Coenzyme A; Cell Proliferation; Cells, Cultured; Cyclins; Fibroblasts; G1 Phase; Heart Atria; Heart Ventricles; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Resting Phase, Cell Cycle; RNA, Messenger; Simvastatin; Ventricular Remodeling | 2016 |
Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis.
Topics: Acyl Coenzyme A; Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Bleomycin; Cell Cycle Proteins; Cell Nucleus; Cytoplasm; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Phosphoproteins; Pulmonary Fibrosis; Signal Transduction; Simvastatin; Small Molecule Libraries; YAP-Signaling Proteins | 2020 |
Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
Topics: Acyl Coenzyme A; Adenine; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Cysteine; Dietary Supplements; Humans; Hypercholesterolemia; Iron; Magnesium; Male; Rats, Sprague-Dawley; Receptors, LDL; Renal Insufficiency, Chronic; Simvastatin; Uremia; Vascular Calcification | 2020 |
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG-CoA reductase inhibition.
Topics: Acyl Coenzyme A; Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mice; Muscle, Skeletal; Muscular Diseases; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sheep; Simvastatin | 2022 |
Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity.
Topics: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Phylogeny; RNA, Ribosomal, 16S; Simvastatin | 2023 |