Compounds > 3-hydroxy-3-methylglutaryl-coenzyme a

3-hydroxy-3-methylglutaryl-coenzyme a and pyrroles

3-hydroxy-3-methylglutaryl-coenzyme a has been researched along with pyrroles in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cilla, DD; Gibson, DM; Posvar, EL; Sedman, AJ; Whitfield, LR1
Bakker-Arkema, RG; Black, DM; Nawrocki, JW1
Adzet, T; Alegret, M; Díaz, C; Hernández, G; Laguna, JC; Peris, C; Sánchez, RM; Vázquez, M; Verd, JC1
Dostal, LA; Juneau, P; Rothwell, CE1
Aragoncillo, P; Cachofeiro, V; Cediel, E; de las Heras, N; Díaz, C; Hernández, G; Lahera, V; Oubiña, MP; Sanz-Rosa, D1
Bösel, J; Dirnagl, U; Djoufack, PC; Endres, M; Fink, KB; Gandor, F; Harms, C; Harms, U; Hörtnagl, H; Megow, D; Synowitz, M1
Belazi, D; Dickson, M; Meissner, B; Reeder, CE; Senevirante, V; Shinogle, J1
Cai, DQ; Kim, CS; Kim, DH; Kim, SK; Lee, KJ; Qi, XF; Qin, JW; Wu, Z; Yu, YH; Zheng, L1

Trials

2 trial(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and pyrroles

ArticleYear
Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects.
    Clinical pharmacology and therapeutics, 1996, Volume: 60, Issue:6

    Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Area Under Curve; Atorvastatin; Cholesterol; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Enzyme Inhibitors; Female; Half-Life; Heptanoic Acids; Humans; Least-Squares Analysis; Linear Models; Male; Middle Aged; Pyrroles; Reference Values

1996
An overview of the clinical safety profile of atorvastatin (lipitor), a new HMG-CoA reductase inhibitor.
    Archives of internal medicine, 1998, Mar-23, Volume: 158, Issue:6

    Topics: Acyl Coenzyme A; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Creatine Kinase; Female; Heptanoic Acids; Humans; Liver; Male; Middle Aged; Muscles; Pyrroles; Transaminases

1998

Other Studies

6 other study(ies) available for 3-hydroxy-3-methylglutaryl-coenzyme a and pyrroles

ArticleYear
Different effect of simvastatin and atorvastatin on key enzymes involved in VLDL synthesis and catabolism in high fat/cholesterol fed rabbits.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Atorvastatin; Cholesterol, Dietary; Choline-Phosphate Cytidylyltransferase; Enzymes; Heptanoic Acids; Lipids; Lipoprotein Lipase; Lipoproteins, VLDL; Liver; Male; Phospholipids; Pyrroles; Rabbits; Simvastatin; Sterol O-Acyltransferase; Triglycerides

1999
Repeated analysis of semen parameters in beagle dogs during a 2-year study with the HMG-CoA reductase inhibitor, atorvastatin.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 61, Issue:1

    Topics: Acyl Coenzyme A; Animals; Atorvastatin; Cholesterol; Dogs; Ejaculation; Epididymis; Heptanoic Acids; Male; Organ Size; Prostate; Pyrroles; Semen; Sperm Count; Sperm Motility; Spermatozoa; Testis; Time Factors

2001
Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:6

    Topics: Acyl Coenzyme A; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Arteriosclerosis; Atorvastatin; Blood Pressure; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fibrinolysis; Heptanoic Acids; Hypercholesterolemia; In Vitro Techniques; Inflammation Mediators; Male; Pyrroles; Quinapril; Rabbits; Tetrahydroisoquinolines; Tunica Intima; Vasodilation

2003
Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones.
    Journal of neurochemistry, 2005, Volume: 92, Issue:6

    Topics: Acyl Coenzyme A; Animals; Apoptosis; Atorvastatin; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Glucose; Glutamic Acid; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoxia-Ischemia, Brain; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxins; Pyrroles; Rats; Receptors, Glutamate

2005
Drug and medical cost effects of a drug formulary change with therapeutic interchange for statin drugs in a multistate managed Medicaid organization.
    Journal of managed care pharmacy : JMCP, 2006, Volume: 12, Issue:4

    Topics: Acyl Coenzyme A; Atorvastatin; Drug Costs; Dyslipidemias; Female; Formularies as Topic; Health Expenditures; Heptanoic Acids; Humans; Insurance Claim Review; Male; Managed Care Programs; Medicaid; Middle Aged; Pyrroles; Retrospective Studies; Therapeutic Equivalency

2006
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.
    Cell death & disease, 2013, Feb-28, Volume: 4

    Topics: Acetylcysteine; Acyl Coenzyme A; Animals; Antioxidants; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lymphoma; Membrane Potential, Mitochondrial; Mevalonic Acid; Mice; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species; Signal Transduction; Simvastatin

2013