3-hydroxy-3-methylglutaryl-coenzyme a has been researched along with mevalonic acid in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (12.90) | 18.7374 |
| 1990's | 15 (24.19) | 18.2507 |
| 2000's | 14 (22.58) | 29.6817 |
| 2010's | 20 (32.26) | 24.3611 |
| 2020's | 5 (8.06) | 2.80 |
| Authors | Studies |
|---|---|
| Bach, TJ; Boronat, A; Caelles, C; Ferrer, A; Weber, T; Wettstein, A | 1 |
| Heuman, DM; Hylemon, PB; Pandak, WM; Vlahcevic, ZR | 1 |
| Azrolan, NI; Coleman, PS | 1 |
| Meenan, A; Popják, G | 1 |
| Langan, TJ; Volpe, JJ | 1 |
| Bolds, J; Cabrera, JA; Havel, CM; Shields, PE; Watson, JA | 1 |
| Baker, FC; Schooley, DA | 1 |
| Lachance, PA; Ott, DB | 1 |
| Krieger, M | 1 |
| Rabinowitz, JL; Tulenko, TN | 1 |
| Domnas, AJ; Gallagher, PA; Warner, SA | 1 |
| Beck, H; Gebhardt, R; Wagner, KG | 1 |
| Horbach, S; Sahm, H; Welle, R | 1 |
| Bischoff, KM; Rodwell, VW | 1 |
| Erl, W; Weber, C; Weber, PC | 1 |
| Naoumova, RP; Thompson, GR; Watts, GF | 1 |
| Murota, S; Sato-Suzuki, I | 1 |
| Cuthbert, JA; Lipsky, PE | 1 |
| Archer, MC; El-Sohemy, A | 1 |
| Hirai, A; Kitagawa, M; Oeda, T; Saito, Y; Tanaka, T; Tatsuno, I; Yasuda, T | 1 |
| Kim, KD; Naoumova, RP; Pfohl, M; Thompson, GR | 1 |
| Avalos, J; Cerdá-Olmedo, E; Domenech, CE; Fernández-Martín, R; Giordano, W | 1 |
| Bochar, DA; Kim, DY; Rodwell, VW; Stauffacher, CV | 1 |
| Chan, P; Chang, JJ; Chen, TH; Chen, YJ; Hsu, FL; Lin, JY; Lo, MY | 1 |
| Kapur, N; Kumar, R; Singh, RP | 1 |
| Distl, R; Glöckner, F; Meske, V; Ohm, TG; Schönheit, B; Tamanai, M; Treiber-Held, S | 1 |
| Ishimi, Y | 1 |
| Møller, K; Nielsen, J; Seker, T | 1 |
| Mokashi, V; Porter, TD; Singh, DK | 1 |
| Bode, HB; Gaitatzis, N; Mahmud, T; Müller, R; Wan, E; Wen, KW; Wenzel, SC | 1 |
| Baker, SK; Tarnopolsky, MA | 1 |
| Hou, Z; Kistler, HC; Li, L; Seong, K; Tracy, M; Xu, JR | 1 |
| Altundag, K; Bulut, N; Dincer, M; Harputluoglu, H | 1 |
| de Ruyck, J; Wouters, J | 1 |
| Ewering, C; Kroll, J; Reichelt, R; Steinbüchel, A; Steinle, A | 1 |
| Bode, HB; Lorenzen, W; Ring, MW; Schwär, G | 1 |
| Liu, J; Zhao, S; Zhou, W | 1 |
| Musso, A; Poggi, A; Zocchi, MR | 1 |
| Hamashima, H; Hirohara, M; Inoue, Y; Kaneko, M; Togashi, N | 1 |
| Imano, M; Itoh, T; Nishida, S; Satou, T; Tsubaki, M; Yamazoe, Y; Yanae, M | 1 |
| Kundumani-Sridharan, V; Rao, GN; Singh, NK | 1 |
| de Fuentes, I; García-Castellano, JM; Loftus, B; López-Arencibia, A; Lorenzo-Morales, J; Machin, RP; Maciver, SK; Martín-Navarro, CM; Piñero, JE; Valladares, B | 1 |
| Furuta, T; Ikuma, M; Miyajima, H; Osawa, S; Sugimoto, K; Sugimoto, M; Takayanagi, Y; Yamada, T; Zhang, J | 1 |
| Cai, DQ; Kim, CS; Kim, DH; Kim, SK; Lee, KJ; Qi, XF; Qin, JW; Wu, Z; Yu, YH; Zheng, L | 1 |
| Ghosh, M; Sengupta, A | 1 |
| Corson, MH; Dembinski, HE; Driver, J; Gordon, SS; Peacock, RB; Schwarz, BH; Watson, JM | 1 |
| Dhople, VM; Kanugula, AK; Kotamraju, S; Ummanni, R; Völker, U | 1 |
| Chen, GP; Du, CQ; Han, J; Li, L; Wu, T; Zhang, XQ | 1 |
| Clarke, K; Kemper, MF; Pawlosky, RJ; Srivastava, S; Todd King, M; Veech, RL | 1 |
| Ande, SR; Chen, QM; Hashemi, M; Hoshyar, R; Naderi, M; Solomon, C; Zuse, A | 1 |
| Abebayehu, D; Barnstein, BO; Chalfant, CE; Faber, T; Haque, TT; Kazmi, QA; Kolawole, EM; McLeod, JJ; Ndaw, V; Oskeritzian, CA; Paranjape, A; Qayum, AA; Ryan, JJ; Spence, AJ; Straus, DB; Sturgill, JL; Taruselli, M; Wijesinghe, DS | 1 |
| DeFranco, A; Emelyanova, L; Holmuhamedov, A; Holmuhamedov, E; Jahangir, A; Kress, D; Negmadjanov, U; Rizvi, F; Ross, G; Shi, Y; Siddiqui, R; Tajik, AJ | 1 |
| Gulipalli, J; Mukherjee, V; Premalatha, R; Srikumar, K; Sufi, SA; Velan, A; Vijayalaksmi, D | 1 |
| Dalwadi, MP; Garavaglia, M; King, JR; Minton, NP; Webb, JP | 1 |
| Allmann, S; Bertiaux, E; Biran, M; Bouyssou, G; Bringaud, F; Crouzols, A; Dittrich-Domergue, F; Fouillen, L; Kiema, TR; Mazet, M; Millerioux, Y; Moreau, P; Plazolles, N; Rotureau, B; Thapa, C; Wierenga, RK | 1 |
| Brown, AJ; Coates, HW | 1 |
| Bai, R; Bode, AM; Chang, X; Dong, Z; Li, X; Liu, K; Ma, W; Ryu, J; Song, Y; Wang, K; Wang, Q; Wang, T; Xia, Q; Zhang, T | 1 |
| Bieler, M; Black, KE; Grasberger, P; Hariri, LP; Lin, Y; Medoff, BD; Nichols, R; Nicklin, P; Pantano, L; Probst, CK; Pronzati, G; Santos, DM; Seither, P; Spinney, JJ; Tager, AM; Wyatt, D | 1 |
| Hynds, DL; Raut, NGR; Reddy, JM; Seifert, JL | 1 |
| Fujihara, N; Inada, T; Juntila, DJ; Suzuki, I; Yang, T; Yoneda, K | 1 |
| Bond, CS; Breese, KJ; Haywood, J; Mylne, JS; Stubbs, KA; Waters, MT; Zhang, J | 1 |
| Bose, S; Kulathunga, SC; Lipton, M; López-Pérez, D; Mesecar, AD; Rodwell, VW; Schmidt, T; Seleem, MN; Stauffacher, CV; Steussy, CN | 1 |
8 review(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and mevalonic acid
| Article | Year |
|---|---|
Biochemical controls of liver cholesterol biosynthesis.
Topics: Acetates; Acetyl Coenzyme A; Acyl Coenzyme A; Allosteric Regulation; Animals; Bile Acids and Salts; Cells, Cultured; Cholesterol; Cholesterol, Dietary; Circadian Rhythm; Diet; Diphosphates; Enterohepatic Circulation; Fasting; Feedback; Female; Food; Humans; Hydroxymethylglutaryl CoA Reductases; Lipoproteins, LDL; Liver; Male; Meglutol; Mevalonic Acid; Rats; Receptors, Cell Surface; Receptors, LDL; Squalene; Tretinoin | 1981 |
Role of cholesterol in regulating apolipoprotein B secretion by the liver.
Topics: Acyl Coenzyme A; Animals; Apolipoproteins B; Bile; Cholesterol; Cholesterol Esters; Humans; Hyperlipoproteinemia Type II; Lipid Metabolism; Lipoproteins; Lipoproteins, VLDL; Liver; Mevalonic Acid | 1996 |
Molecular regulation of cholesterol biosynthesis: implications in carcinogenesis.
Topics: Acyl Coenzyme A; Antineoplastic Agents; Cell Division; Cell Transformation, Neoplastic; Cholesterol; Humans; Mevalonic Acid; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction | 2003 |
[The role of mevalonate pathway in osteogenic cells].
Topics: Acyl Coenzyme A; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bone Resorption; Cell Differentiation; Diphosphonates; Fractures, Bone; GTP-Binding Proteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Osteoblasts; Osteoclasts; Osteogenesis; Osteoporosis; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Signal Transduction; Transforming Growth Factor beta | 2004 |
Statin-associated neuromyotoxicity.
Topics: Acyl Coenzyme A; Adverse Drug Reaction Reporting Systems; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Muscular Diseases; Peripheral Nervous System Diseases; Rhabdomyolysis; Terpenes; Ubiquinone | 2005 |
Structure-based drug design targeting biosynthesis of isoprenoids: a crystallographic state of the art of the involved enzymes.
Topics: Acyl Coenzyme A; Animals; Bacteria; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Enzymes; Fungi; Hemiterpenes; Humans; Mevalonic Acid; Organophosphorus Compounds; Plants; Terpenes | 2008 |
Mevalonate Cascade and its Regulation in Cholesterol Metabolism in Different Tissues in Health and Disease.
Topics: Acyl Coenzyme A; Animals; Cardiovascular Diseases; Cholesterol; GTP Phosphohydrolases; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infections; Mevalonic Acid; Neoplasms; Polyisoprenyl Phosphates; Sesquiterpenes; Signal Transduction | 2017 |
Regulation of Small GTPase Prenylation in the Nervous System.
Topics: Acyl Coenzyme A; Amino Acid Motifs; Animals; Biosynthetic Pathways; Cell Membrane; Dimethylallyltranstransferase; Enzyme Activation; GTP Phosphohydrolases; Humans; Methylation; Mevalonic Acid; Nerve Tissue Proteins; Protein Binding; Protein Prenylation; Terpenes | 2020 |
1 trial(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and mevalonic acid
| Article | Year |
|---|---|
An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans.
Topics: 3-Hydroxybutyric Acid; Acyl Coenzyme A; Adult; Animals; Anticholesteremic Agents; Beverages; Biomarkers; Breakfast; Cell Membrane; Cholesterol; Dietary Supplements; Female; Humans; Hydroxybutyrates; Liver; Male; Mevalonic Acid; Rats, Sprague-Dawley; Receptors, LDL; Sterol Regulatory Element Binding Protein 2; Young Adult | 2015 |
53 other study(ies) available for 3-hydroxy-3-methylglutaryl-coenzyme a and mevalonic acid
| Article | Year |
|---|---|
Aspects related to mevalonate biosynthesis in plants.
Topics: Acetyl Coenzyme A; Acetyl-CoA C-Acetyltransferase; Acyl Coenzyme A; Amino Acid Sequence; DNA; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Molecular Sequence Data; Oxo-Acid-Lyases; Plants | 1991 |
Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis.
Topics: Acyl Coenzyme A; Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Dehydrocholesterols; Down-Regulation; Kinetics; Liver; Male; Mevalonic Acid; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |
A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system.
Topics: Acetates; Acyl Coenzyme A; Animals; Cell Membrane; Cell-Free System; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Lanosterol; Liver; Liver Neoplasms, Experimental; Male; Mevalonic Acid; Microsomes, Liver; Rats; Rats, Inbred Strains; Squalene | 1989 |
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase: search for the enzyme's repressor derived from mevalonate.
Topics: Acyl Coenzyme A; Animals; Cholesterol; DNA; Enzyme Inhibitors; Gene Expression Regulation; Isomerases; Liver Neoplasms, Experimental; Mevalonic Acid; Naphthols; Oxygenases; Quaternary Ammonium Compounds; Rats; Repressor Proteins; Squalene; Transcription Factors; Tumor Cells, Cultured | 1987 |
Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acyl Coenzyme A; Animals; Bucladesine; Cell Differentiation; Cells, Cultured; Cholesterol; Lovastatin; Mevalonic Acid; Naphthalenes; Neuroglia; Oligodendroglia; Rats; Rats, Inbred Strains | 1987 |
Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability.
Topics: Acyl Coenzyme A; Halobacterium; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipids; Lovastatin; Mevalonic Acid; NADP; Naphthalenes | 1986 |
Biosynthesis of 3-hydroxy-3-methylglutaryl-CoA, 3-hydroxy-3-ethylglutaryl-CoA, mevalonate and homomevalonate by insect corpus allatum and mammalian hepatic tissues.
Topics: Acyl Coenzyme A; Animals; Coleoptera; Corpora Allata; Fat Body; Female; Glutarates; Grasshoppers; Hydroxymethylglutaryl CoA Reductases; Lepidoptera; Liver; Male; Meglutol; Mevalonic Acid; Moths; Rats | 1981 |
The use of amphotericin B to detect inhibitors of cellular cholesterol biosynthesis.
Topics: Acyl Coenzyme A; Amphotericin B; Animals; Cell Line; Cell Survival; Cholesterol; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Mevalonic Acid; Naphthalenes | 1983 |
Metabolism of C14 mevalonate by adult and fetal arteries.
Topics: Acyl Coenzyme A; Animals; Aorta, Thoracic; Cholesterol; Female; Fetus; Gestational Age; Mevalonic Acid; Oleic Acid; Oleic Acids; Palmitic Acid; Palmitic Acids; Pregnancy; Rabbits; Stearic Acids; Umbilical Arteries | 1983 |
Presqualene metabolism in two species of Lagenidium.
Topics: Acetates; Acyl Coenzyme A; Fatty Acids; Glucose; Lipid Metabolism; Mevalonic Acid; Oomycetes; Sterols | 1994 |
Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells.
Topics: Acetates; Acyl Coenzyme A; Animals; Cholesterol; Disulfides; Hypolipidemic Agents; Liver; Male; Mevalonic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Sulfinic Acids; Sulfoxides; Tumor Cells, Cultured | 1994 |
Isoprenoid biosynthesis in bacteria: two different pathways?
Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Bacteria; Escherichia coli; Halobacterium; Hemiterpenes; Lactobacillus; Mevalonic Acid; Myxococcus; Organophosphorus Compounds; Species Specificity; Staphylococcus; Terpenes; Zymomonas | 1993 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli.
Topics: Acyl Coenzyme A; Acylation; Aldehydes; Carrier Proteins; Escherichia coli; Genes, Bacterial; Halobacteriaceae; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Membrane Proteins; Membrane Transport Proteins; Mevalonic Acid; Molecular Weight; NADP; Potassium Chloride; Recombinant Fusion Proteins; Stereoisomerism | 1996 |
Lovastatin induces differentiation of Mono Mac 6 cells.
Topics: Acyl Coenzyme A; Biomarkers; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Monocytes; Tumor Necrosis Factor-alpha; Umbilical Veins | 1995 |
Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells.
Topics: Acyl Coenzyme A; Animals; Cell Division; Enzyme Inhibitors; Lovastatin; Mevalonic Acid; Neurites; PC12 Cells; Pravastatin; Rats; Simvastatin | 1996 |
Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism.
Topics: Acyl Coenzyme A; Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Humans; Leukemia; Lovastatin; Lymphoma; Mevalonic Acid; Neoplasm Proteins; ras Proteins; Tumor Cells, Cultured | 1997 |
Regulation of mevalonate synthesis in rat mammary glands by dietary n-3 and n-6 polyunsaturated fatty acids.
Topics: Acyl Coenzyme A; Animals; Cholesterol; Fatty Acids, Unsaturated; Female; Fish Oils; Mammary Glands, Animal; Mevalonic Acid; Rats; Rats, Sprague-Dawley; Safflower Oil | 1997 |
Geranylgeranylpyrophosphate, a metabolite of mevalonate, regulates the cell cycle progression and DNA synthesis in human lymphocytes.
Topics: Acyl Coenzyme A; Biological Transport; Cell Cycle; DNA; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liposomes; Lymphocytes; Mevalonic Acid; Phytohemagglutinins; Polyisoprenyl Phosphates; Pravastatin; RNA, Messenger; Sesquiterpenes | 1997 |
Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions.
Topics: Acyl Coenzyme A; Adult; Analysis of Variance; Anticholesteremic Agents; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Meglutol; Mevalonic Acid; Simvastatin | 1998 |
Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi.
Topics: Acyl Coenzyme A; Amino Acid Sequence; Blotting, Southern; Carotenoids; DNA, Fungal; Fungal Proteins; Gibberella; Gibberellins; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Physical Chromosome Mapping; Polymerase Chain Reaction; Sequence Alignment; Sterols; Time Factors | 1999 |
Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.
Topics: Acyl Coenzyme A; Acylation; Chromatography, Agarose; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; RNA, Transfer, Arg; Sulfolobus | 1999 |
The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coenzyme a reductase on vero cells.
Topics: Acyl Coenzyme A; Animals; Antioxidants; Biflavonoids; Catechin; Cell Count; Cell Division; Chlorocebus aethiops; Flavonoids; Hydrolyzable Tannins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Phenols; Polymers; Pravastatin; Proanthocyanidins; Sodium Acetate; Vero Cells | 2001 |
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease.
Topics: Acyl Coenzyme A; Alzheimer Disease; Analysis of Variance; Animals; Anticholesteremic Agents; Astrocytes; Blotting, Western; Brain Chemistry; Calcium; Cerebral Cortex; Cholesterol; Dextrans; Drug Interactions; Filipin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microglia; Microtubules; Neurofibrillary Tangles; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; rho GTP-Binding Proteins; RNA, Messenger; tau Proteins; Tubulin | 2003 |
Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae.
Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Ethanol; Galactose; Glucose; Mevalonic Acid; Saccharomyces cerevisiae | 2005 |
Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.
Topics: Acetic Acid; Acyl Coenzyme A; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Survival; Cholesterol; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Humans; Immunoblotting; Kinetics; Lipoproteins; Mevalonic Acid; Microsomes, Liver; Molecular Weight; Oxygenases; Protein Kinase C; Rats; Recombinant Proteins; Squalene; Squalene Monooxygenase; Trans-Activators | 2005 |
A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway.
Topics: Acyl Coenzyme A; Animals; Glutarates; Leucine; Methacrylates; Mevalonic Acid; Molecular Structure; Myxococcales; Quinolines; Stigmatella aurantiaca; Thiazoles | 2005 |
Cryptic promoter activity in the coding region of the HMG-CoA reductase gene in Fusarium graminearum.
Topics: Acyl Coenzyme A; Catalytic Domain; Fungal Proteins; Fusarium; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Mevalonic Acid; Mutation; Plant Diseases; Poaceae; Promoter Regions, Genetic; Terminal Repeat Sequences; Transcription, Genetic | 2006 |
Statins may decrease skeletal-related events in breast cancer patients with bone metastases.
Topics: Acyl Coenzyme A; Apoptosis; Bone and Bones; Bone Neoplasms; Breast Neoplasms; Cell Division; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Neoplasm Metastasis; Osteoclasts | 2006 |
Establishment of a novel anabolism-based addiction system with an artificially introduced mevalonate pathway: complete stabilization of plasmids as universal application in white biotechnology.
Topics: Acyl Coenzyme A; Anti-Bacterial Agents; Bacterial Proteins; Cloning, Molecular; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genetic Engineering; Hemiterpenes; Mevalonic Acid; Mutation; Organophosphorus Compounds; Oxidoreductases; Peptide Synthases; Plasmids; Staphylococcus aureus | 2009 |
Isoprenoids are essential for fruiting body formation in Myxococcus xanthus.
Topics: Acyl Coenzyme A; Bacterial Proteins; Culture Media; Gene Expression Regulation, Bacterial; Mevalonic Acid; Mutation; Myxococcus xanthus; Terpenes | 2009 |
Synthesis and HMG-CoA reductase inhibition of 2-cyclopropyl-4-thiophenyl-quinoline mevalonolactones.
Topics: Acyl Coenzyme A; Animals; Cyclopropanes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Magnetic Resonance Spectroscopy; Mevalonic Acid; Quinolines; Rats; Spectrometry, Mass, Electrospray Ionization; Sulfhydryl Compounds | 2009 |
Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival.
Topics: Actins; Acyl Coenzyme A; Apoptosis; B-Lymphocytes; Blotting, Western; Bone Marrow Cells; Cell Communication; Cell Cycle; Cell Proliferation; Cells, Cultured; Coculture Techniques; Fatty Acids, Monounsaturated; Flow Cytometry; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lymphocyte Activation; Mesenchymal Stem Cells; Mevalonic Acid; Protein Prenylation; rhoA GTP-Binding Protein; Stromal Cells; T-Lymphocytes | 2011 |
Effect of farnesol on mevalonate pathway of Staphylococcus aureus.
Topics: Acyl Coenzyme A; Anti-Bacterial Agents; Culture Media; Farnesol; Humans; Mevalonic Acid; Staphylococcus aureus | 2011 |
Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma.
Topics: Acyl Coenzyme A; Apoptosis; Cell Growth Processes; Cell Survival; Enzyme Activation; Female; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Polyisoprenyl Phosphates; Proto-Oncogene Proteins c-akt | 2011 |
12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation.
Topics: Acyl Coenzyme A; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Cell Movement; Cells, Cultured; Guanine Nucleotide Exchange Factors; Hindlimb; Humans; Hydroxyeicosatetraenoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Mevalonic Acid; Mice; Mice, Knockout; Neovascularization, Physiologic; Neuropeptides; Prenylation; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; Rho Guanine Nucleotide Exchange Factors; Simvastatin | 2011 |
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of statins as a novel effective therapeutic approach against Acanthamoeba infections.
Topics: Acanthamoeba castellanii; Acyl Coenzyme A; Amino Acid Sequence; Catalytic Domain; Cell Proliferation; Cells, Cultured; Enzyme Assays; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Inhibitory Concentration 50; Mevalonic Acid; Molecular Sequence Data; Protozoan Proteins; RNA, Small Interfering | 2013 |
Statins directly suppress cytokine production in murine intraepithelial lymphocytes.
Topics: Acyl Coenzyme A; Animals; Cell Survival; Cytokines; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Lymphocytes; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Phenotype; Polyisoprenyl Phosphates; Sesquiterpenes; Simvastatin; Spleen; Time Factors | 2013 |
HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.
Topics: Acetylcysteine; Acyl Coenzyme A; Animals; Antioxidants; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lymphoma; Membrane Potential, Mitochondrial; Mevalonic Acid; Mice; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Reactive Oxygen Species; Signal Transduction; Simvastatin | 2013 |
Protective role of phytosterol esters in combating oxidative hepatocellular injury in hypercholesterolemic rats.
Topics: Acyl Coenzyme A; Animals; Antioxidants; Esters; Fatty Acids; Hypercholesterolemia; Lipid Metabolism; Liver; Liver Diseases; Liver Function Tests; Male; Malondialdehyde; Mevalonic Acid; Oxidative Stress; Phytosterols; Rats; Rats, Wistar | 2013 |
Kinetic characterization of an oxidative, cooperative HMG-CoA reductase from Burkholderia cenocepacia.
Topics: Acyl Coenzyme A; Amino Acid Sequence; Burkholderia cenocepacia; Cloning, Molecular; Coenzymes; Hydroxymethylglutaryl CoA Reductases; Kinetics; Mevalonic Acid; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Terpenes | 2014 |
Fluvastatin mediated breast cancer cell death: a proteomic approach to identify differentially regulated proteins in MDA-MB-231 cells.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Epithelial-Mesenchymal Transition; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Indoles; Metabolic Networks and Pathways; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Proteome; Tandem Mass Spectrometry; Vimentin | 2014 |
Alteration of mevalonate pathway in proliferated vascular smooth muscle from diabetic mice: possible role in high-glucose-induced atherogenic process.
Topics: Acyl Coenzyme A; Alkyl and Aryl Transferases; Animals; Aorta; Atherosclerosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Farnesyltranstransferase; Female; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Geranyltranstransferase; Glucose; Inflammation; Lipids; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular | 2015 |
Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects.
Topics: Acyl Coenzyme A; Animals; Apoptosis; Basophils; Cells, Cultured; Cytokines; Farnesyltranstransferase; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin E; Indoles; Mast Cells; Mevalonic Acid; Mice; Mice, Inbred C57BL; Signal Transduction; Th2 Cells | 2016 |
Chamber-specific differences in human cardiac fibroblast proliferation and responsiveness toward simvastatin.
Topics: Acyl Coenzyme A; Cell Proliferation; Cells, Cultured; Cyclins; Fibroblasts; G1 Phase; Heart Atria; Heart Ventricles; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Resting Phase, Cell Cycle; RNA, Messenger; Simvastatin; Ventricular Remodeling | 2016 |
A plant oxysterol, 28-homobrassinolide binds HMGCoA reductase catalytic cleft: stereoselective avidity affects enzyme function.
Topics: Acyl Coenzyme A; Animals; Cholestanones; Down-Regulation; Humans; Hydroxymethylglutaryl CoA Reductases; Kidney; Liver; Male; Mevalonic Acid; Molecular Docking Simulation; Rats; Stereoisomerism; Testis | 2016 |
Applying asymptotic methods to synthetic biology: Modelling the reaction kinetics of the mevalonate pathway.
Topics: Acyl Coenzyme A; Hemiterpenes; Kinetics; Metabolic Networks and Pathways; Mevalonic Acid; Models, Theoretical; Organophosphorus Compounds; Synthetic Biology; Terpenes | 2018 |
De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.
Topics: Acetates; Acetyl Coenzyme A; Acetyltransferases; Acyl Coenzyme A; Alcohol Oxidoreductases; Animals; Carbon; Fatty Acids; Gene Expression Regulation; Gene Knockout Techniques; Glucose; Insect Vectors; Leucine; Mevalonic Acid; Proline; Sterols; Threonine; Trypanosoma brucei brucei; Tsetse Flies | 2018 |
A wolf in sheep's clothing: unmasking the lanosterol-induced degradation of HMG-CoA reductase.
Topics: Acyl Coenzyme A; Lanosterol; Mevalonic Acid; Sterol Regulatory Element Binding Protein 1; Sterols | 2019 |
Fluvastatin Inhibits HMG-CoA Reductase and Prevents Non-Small Cell Lung Carcinogenesis.
Topics: Acyl Coenzyme A; Adult; Aged; Animals; Apoptosis; Carcinogenesis; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Female; Fluvastatin; Gene Knockdown Techniques; HEK293 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Lung Neoplasms; Male; Mevalonic Acid; Mice; Middle Aged; Neoplasms, Experimental; Nitrosamines; RNA, Small Interfering; Xenograft Model Antitumor Assays | 2019 |
Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis.
Topics: Acyl Coenzyme A; Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Bleomycin; Cell Cycle Proteins; Cell Nucleus; Cytoplasm; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mice; Phosphoproteins; Pulmonary Fibrosis; Signal Transduction; Simvastatin; Small Molecule Libraries; YAP-Signaling Proteins | 2020 |
Enhancement of Squalene Production by Constitutive Expression of the 3-Hydroxy-3-Methylglutaryl-CoA Reductase in Aurantiochytrium sp. 18W-13a.
Topics: Acyl Coenzyme A; Mevalonic Acid; Squalene; Stramenopiles | 2022 |
A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action.
Topics: Acyl Coenzyme A; Arabidopsis; Herbicides; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid | 2022 |
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor.
Topics: Acyl Coenzyme A; Enterococcus faecalis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid | 2023 |