3-hydroxy-3-methylglutaryl-coenzyme a has been researched along with lovastatin in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.82) | 18.7374 |
| 1990's | 20 (51.28) | 18.2507 |
| 2000's | 5 (12.82) | 29.6817 |
| 2010's | 8 (20.51) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, L; Gui, J; Li, J; Qiu, S; Ren, Y; Sun, Y; Wan, J; Wang, X; Wei, X; Wu, P; Zhou, L | 1 |
| Umezawa, K | 1 |
| Bennett, JL; Chen, GZ; Foster, L | 1 |
| Ehnholm, C; Heikkilä, P; Kahri, AI; Kovanen, PT | 1 |
| Allan, J; Johnson, BF; LaBelle, P; Ronca, PD; Wilson, J; Zupkis, RV | 1 |
| Behnke, CE; Laib, FE; Miziorko, HM | 1 |
| Langan, TJ; Volpe, JJ | 1 |
| Bolds, J; Cabrera, JA; Havel, CM; Shields, PE; Watson, JA | 1 |
| Björkhem, I | 1 |
| Abeles, RH; Nakamura, CE | 1 |
| Krieger, M | 1 |
| Chen, TS; Ness, GC; Salen, G; Salen, L; Shefer, S; Tint, GS; Xu, G; Zhao, Z | 1 |
| Ashwell, K; Balabanov, YV; Bobryshev, YV; Pavlov, OV | 1 |
| Himberg, JJ; Jokelainen, K; Laaksonen, R; Sahi, T; Tikkanen, MJ | 1 |
| Batta, A; Chowdhary, IR; Hauser, S; Ness, GC; Nguyen, LB; Paroulek, E; Salen, G; Shefer, S | 1 |
| Bischoff, KM; Rodwell, VW | 1 |
| Erl, W; Weber, C; Weber, PC | 1 |
| Cooper, ME; Gilbert, RE; Jerums, G | 1 |
| Illingworth, R | 1 |
| Pahor, M | 1 |
| Hosomi, N; Izumi, Y; Kitadai, M; Satoh, K; Takahashi, T; Tsuda, Y | 1 |
| Murota, S; Sato-Suzuki, I | 1 |
| Cuthbert, JA; Lipsky, PE | 1 |
| Avalos, J; Cerdá-Olmedo, E; Domenech, CE; Fernández-Martín, R; Giordano, W | 1 |
| Mabuchi, H | 1 |
| Bochar, DA; Kim, DY; Rodwell, VW; Stauffacher, CV | 1 |
| Jacobson, TA | 1 |
| Distl, R; Glöckner, F; Meske, V; Ohm, TG; Schönheit, B; Tamanai, M; Treiber-Held, S | 1 |
| Liang, Y; Mirnics, ZK; Nylander, KD; Portugal, CF; Rudzinski, M; Saragovi, HU; Schor, NF; Yan, C; Zaccaro, C | 1 |
| Haeffner, EW; Kiesewetter, L; Spiess, E; Stöhr, M; Wittmann, U; Zimmermann, HP | 1 |
| Coselli, J; Gan, Y; Wang, J; Wang, XL | 1 |
| Chang, LC; Chen, JS; Hwang, JC; Lin, YF; Shui, HA | 1 |
| Choi, DH; Choi, JS; Yang, SH | 1 |
| Chen, H; Fang, D; Jiang, D; Ma, G; Tian, C; Zhou, J | 1 |
| Chin, J; Faseleh Jahromi, M; Goh, YM; Ho, YW; Liang, JB; Mohamad, R; Shokryazdan, P | 1 |
| Baumgarten, G; Frede, S; Hilbert, T; Hoeft, A; Klaschik, S; Knuefermann, P; Poth, J | 1 |
| Dinesh, N; Singh, S; Soumya, N | 1 |
| Ding, ZT; Li, YQ; Liu, SX; Luo, N; Miao, CP; Wang, Q; Yang, XQ; Yang, YB; Zhao, LX | 1 |
| Archunan, G; Balraj, J; Dhanapal, AR; Jairaman, K; Jayaraman, A; Kalieswaran, V; Murugesan, T | 1 |
3 review(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and lovastatin
| Article | Year |
|---|---|
[Biological activity of oncogene function inhibitors isolated from microorganisms].
Topics: Acyl Coenzyme A; Animals; Bacteria; Furans; Genistein; Hydroquinones; Isoflavones; Lovastatin; Oncogene Proteins; Phosphatidylinositols; Protein-Tyrosine Kinases | 1992 |
[Clinical studies on hyperlipidemia].
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Blood Component Removal; Clinical Trials as Topic; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin | 1999 |
"The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline?.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Risk Factors; Simvastatin | 2000 |
2 trial(s) available for 3-hydroxy-3-methylglutaryl-coenzyme a and lovastatin
| Article | Year |
|---|---|
Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscles; Simvastatin; Ubiquinone | 1995 |
Effects of pravastatin sodium and simvastatin on plasma fibrinogen level and blood rheology in type II hyperlipoproteinemia.
Topics: Acyl Coenzyme A; Blood Viscosity; Cholesterol; Enzyme Inhibitors; Female; Fibrinogen; Hematocrit; Hemorheology; Humans; Hyperlipoproteinemias; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Triglycerides | 1996 |
34 other study(ies) available for 3-hydroxy-3-methylglutaryl-coenzyme a and lovastatin
| Article | Year |
|---|---|
Specific inhibitions of annonaceous acetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase from Streptococcus pneumoniae.
Topics: Acetogenins; Amino Acid Sequence; Binding Sites; Computer Simulation; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Molecular Sequence Data; Protein Structure, Tertiary; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Streptococcus pneumoniae | 2011 |
Purification and characterization of 3-hydroxymethylglutaryl-coenzyme A reductase of Schistosoma mansoni: regulation of parasite enzyme activity differs from mammalian host.
Topics: Acyl Coenzyme A; Animals; Cholesterol, Dietary; Cholestyramine Resin; Circadian Rhythm; Enzyme Activation; Female; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Male; Mice; Microsomes, Liver; NADP; Rats; Schistosoma mansoni; Schistosomiasis mansoni | 1991 |
Effects of mevinolin, an inhibitor of cholesterol synthesis, on the morphology and function of differentiating and differentiated rat adrenocortical cells in primary culture.
Topics: Acyl Coenzyme A; Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cell Differentiation; Cells, Cultured; Cholesterol; Lovastatin; Microscopy, Electron; Rats; Rats, Inbred Strains | 1990 |
Effects of lovastatin in diabetic patients treated with chlorpropamide.
Topics: Acyl Coenzyme A; Administration, Oral; Apolipoproteins B; Blood Glucose; Chlorpropamide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Time Factors | 1990 |
Evidence for substrate channeling in the early steps of cholesterogenesis.
Topics: Acetates; Acetoacetates; Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Brain; Carbon Isotopes; Cholesterol; Cholestyramine Resin; Cytosol; Female; Gas Chromatography-Mass Spectrometry; Liver; Lovastatin; Rats; Rats, Inbred Strains | 1990 |
Oligodendroglial differentiation in glial primary cultures: requirement for mevalonate.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acyl Coenzyme A; Animals; Bucladesine; Cell Differentiation; Cells, Cultured; Cholesterol; Lovastatin; Mevalonic Acid; Naphthalenes; Neuroglia; Oligodendroglia; Rats; Rats, Inbred Strains | 1987 |
Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability.
Topics: Acyl Coenzyme A; Halobacterium; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipids; Lovastatin; Mevalonic Acid; NADP; Naphthalenes | 1986 |
Effects of mevinolin in rat liver: evidence for a lack of coupling between synthesis of hydroxymethylglutaryl-CoA reductase and cholesterol 7 alpha-hydroxylase activity.
Topics: Acyl Coenzyme A; Animals; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholestyramine Resin; Cricetinae; Diet; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Male; Microsomes, Liver; Naphthalenes; Rats; Rats, Inbred Strains; Steroid Hydroxylases | 1986 |
Mode of interaction of beta-hydroxy-beta-methylglutaryl coenzyme A reductase with strong binding inhibitors: compactin and related compounds.
Topics: Acyl Coenzyme A; Coenzyme A; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mathematics; NADP; Naphthalenes; Pyrans; Pyrones; Saccharomyces cerevisiae | 1985 |
The use of amphotericin B to detect inhibitors of cellular cholesterol biosynthesis.
Topics: Acyl Coenzyme A; Amphotericin B; Animals; Cell Line; Cell Survival; Cholesterol; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Farnesyl-Diphosphate Farnesyltransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Mevalonic Acid; Naphthalenes | 1983 |
Treatment of the cholesterol biosynthetic defect in Smith-Lemli-Opitz syndrome reproduced in rats by BM 15.766.
Topics: Acyl Coenzyme A; Animals; Cholesterol; Cholic Acid; Cholic Acids; Dehydrocholesterols; Disease Models, Animal; Liver; Lovastatin; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome | 1995 |
Structural alterations of human immortal astrocytes after inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by lovastatin.
Topics: Acyl Coenzyme A; Astrocytes; Cell Line, Transformed; Enzyme Inhibitors; Humans; Lovastatin; Microscopy, Electron | 1995 |
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in the rat ileum: effects of bile acids and lovastatin.
Topics: Acyl Coenzyme A; Animals; Bile Acids and Salts; Cholesterol; Cholesterol Esters; Diet; Ileum; Intestinal Mucosa; Jejunum; Lovastatin; Male; Microsomes; Rats; Rats, Sprague-Dawley; Taurochenodeoxycholic Acid; Taurocholic Acid | 1994 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli.
Topics: Acyl Coenzyme A; Acylation; Aldehydes; Carrier Proteins; Escherichia coli; Genes, Bacterial; Halobacteriaceae; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Membrane Proteins; Membrane Transport Proteins; Mevalonic Acid; Molecular Weight; NADP; Potassium Chloride; Recombinant Fusion Proteins; Stereoisomerism | 1996 |
Lovastatin induces differentiation of Mono Mac 6 cells.
Topics: Acyl Coenzyme A; Biomarkers; Cell Adhesion; Cell Differentiation; Cell Division; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique; Humans; Lipopolysaccharide Receptors; Lipopolysaccharides; Lovastatin; Macrophage-1 Antigen; Mevalonic Acid; Monocytes; Tumor Necrosis Factor-alpha; Umbilical Veins | 1995 |
Primary prevention of stroke.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Arteriosclerosis; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypercholesterolemia; Lovastatin; Meta-Analysis as Topic; Oxidoreductases; Pravastatin; Simvastatin | 1996 |
Carcinogenicity of lipid-lowering drugs.
Topics: Acyl Coenzyme A; Gemfibrozil; Humans; Hypolipidemic Agents; Liver; Liver Neoplasms; Lovastatin | 1996 |
Carcinogenicity of lipid-lowering drugs.
Topics: Acyl Coenzyme A; Animals; Enzyme Inhibitors; Humans; Hypolipidemic Agents; Liver; Liver Neoplasms; Lovastatin | 1996 |
Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells.
Topics: Acyl Coenzyme A; Animals; Cell Division; Enzyme Inhibitors; Lovastatin; Mevalonic Acid; Neurites; PC12 Cells; Pravastatin; Rats; Simvastatin | 1996 |
Regulation of proliferation and Ras localization in transformed cells by products of mevalonate metabolism.
Topics: Acyl Coenzyme A; Antineoplastic Agents; Cell Division; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Humans; Leukemia; Lovastatin; Lymphoma; Mevalonic Acid; Neoplasm Proteins; ras Proteins; Tumor Cells, Cultured | 1997 |
Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi.
Topics: Acyl Coenzyme A; Amino Acid Sequence; Blotting, Southern; Carotenoids; DNA, Fungal; Fungal Proteins; Gibberella; Gibberellins; Lovastatin; Mevalonic Acid; Molecular Sequence Data; Physical Chromosome Mapping; Polymerase Chain Reaction; Sequence Alignment; Sterols; Time Factors | 1999 |
Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.
Topics: Acyl Coenzyme A; Acylation; Chromatography, Agarose; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; RNA, Transfer, Arg; Sulfolobus | 1999 |
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease.
Topics: Acyl Coenzyme A; Alzheimer Disease; Analysis of Variance; Animals; Anticholesteremic Agents; Astrocytes; Blotting, Western; Brain Chemistry; Calcium; Cerebral Cortex; Cholesterol; Dextrans; Drug Interactions; Filipin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microglia; Microtubules; Neurofibrillary Tangles; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; rho GTP-Binding Proteins; RNA, Messenger; tau Proteins; Tubulin | 2003 |
Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells.
Topics: Acyl Coenzyme A; Analysis of Variance; Animals; Antibodies, Monoclonal; Apoptosis; Blotting, Northern; Blotting, Western; Cell Count; Cholesterol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation; Geranyltranstransferase; Lovastatin; Microarray Analysis; Nucleic Acid Synthesis Inhibitors; Oxidoreductases Acting on CH-CH Group Donors; PC12 Cells; Phosphorylation; Rats; Receptor, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Zinostatin | 2005 |
Effect of reduced levels of the LDL receptor of Ehrlich ascites tumor cells on cholesterol uptake and cell proliferation: a coculture study with baby hamster kidney cells.
Topics: Acyl Coenzyme A; Animals; Antibodies, Monoclonal; Carcinoma, Ehrlich Tumor; Cell Communication; Cell Proliferation; Cells, Cultured; Cholesterol; Coculture Techniques; Cricetinae; Kidney; Lovastatin; Receptors, LDL | 2007 |
Synergistic induction of apoptosis by HMG-CoA reductase inhibitor and histone deacetylases inhibitor in HeLa cells.
Topics: Acyl Coenzyme A; Apoptosis; Dose-Response Relationship, Drug; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin | 2008 |
Effects of fungal statins on high-glucose-induced mouse mesangial cell hypocontractility may involve filamentous actin, t-complex polypeptide 1 subunit beta, and glucose regulated protein 78.
Topics: Actins; Acyl Coenzyme A; Animals; Cell Division; Endoplasmic Reticulum Chaperone BiP; Glomerular Mesangium; Glucose; Heat-Shock Proteins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Glomerulus; Lovastatin; Mice; Pravastatin; Simvastatin; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetradecanoylphorbol Acetate | 2010 |
Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Topics: Acyl Coenzyme A; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Injections, Intravenous; Losartan; Lovastatin; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Simvastatin; Tetrazoles; Time Factors | 2011 |
Luminol electrochemiluminescence for the analysis of active cholesterol at the plasma membrane in single mammalian cells.
Topics: Acyl Coenzyme A; Amides; Animals; Anticholesteremic Agents; Biological Transport; Cell Line; Cell Membrane; Cholesterol; Cholesterol Oxidase; Electrochemical Techniques; Electrodes; Hydrogen Peroxide; Lovastatin; Luminescent Measurements; Luminol; Macrophages; Mice; Organosilicon Compounds; Single-Cell Analysis; Sterol O-Acyltransferase | 2013 |
Lovastatin in Aspergillus terreus: fermented rice straw extracts interferes with methane production and gene expression in Methanobrevibacter smithii.
Topics: Acyl Coenzyme A; Aspergillus; Fermentation; Gene Expression Regulation, Bacterial; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Methane; Methanobacterium; Oryza; Plant Extracts | 2013 |
Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells.
Topics: Acyl Coenzyme A; Angiopoietin-2; Atherosclerosis; Cell Survival; Cells, Cultured; Endothelial Cells; Exocytosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Nitric Oxide; Nitric Oxide Synthase Type III; Pravastatin; Simvastatin; Weibel-Palade Bodies | 2013 |
Antileishmanial effect of mevastatin is due to interference with sterol metabolism.
Topics: Acyl Coenzyme A; Cell Line; Enzyme Inhibitors; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Lovastatin; Protozoan Proteins; Sterols | 2015 |
Lovastatin analogues and other metabolites from soil-derived Aspergillus terreus YIM PH30711.
Topics: Acetylcholinesterase; Acyl Coenzyme A; Animals; Aspergillus; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Humans; Lovastatin; Macrophages; Mice; Molecular Structure; Nitric Oxide; Stereoisomerism; Structure-Activity Relationship | 2018 |
Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity.
Topics: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Phylogeny; RNA, Ribosomal, 16S; Simvastatin | 2023 |